Supporting Information Synthesis and evaluation of new 3-substituted-4-chloro- thioxanthone derivatives as potent anti-breast cancer agents Chun-Liang Chen a , Tsung-Chih Chen a , Chia-Chung Lee a , Liu-Chuan Shih b , Chih-Yuan Lin b , Ying-Yu Hsieh b , Ahmed Atef Ahmed Ali c, d , Hsu-Shan Huang a, b, c * a Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan, Republic of China b School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, Republic of China c Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, Republic of China d Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan, Republic of China
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Supporting Information
Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as
potent anti-breast cancer agents
Chun-Liang Chena, Tsung-Chih Chena, Chia-Chung Leea, Liu-Chuan Shihb, Chih-Yuan Linb, Ying-Yu Hsiehb, Ahmed Atef Ahmed Alic, d, Hsu-Shan Huanga, b, c*
aGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan, Republic of ChinabSchool of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, Republic of ChinacGraduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, Republic of ChinadInstitute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan, Republic of China
Figure S1. X-ray structure of compound 4c.
Figure S2. One dose mean graph of compound 4b (NSC753740) at 10 M concentration.
Figure S3. One dose mean graph of compound 4f (NSC753748) at 10 M concentration.
Figure S4. One dose mean graph of compound 4j (NSC753741) at 10 M concentration.
Figure S5. One dose mean graph of compound 4s (NSC753744) at 10 M concentration.
Figure S6. One dose mean graph of compound 5b (NSC763938) at 10 M concentration.
Figure S7. One dose mean graph of compound 5f (NSC763940) at 10 M concentration.
Figure S8. One dose mean graph of compound 5j (NSC763942) at 10 M concentration.
Figure S9. One dose mean graph of compound 5s (NSC763947) at 10 M concentration.
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