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0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options Level of risk ALOP Appropriate level of protection A-PDF Split DEMO : Purchase from www.A-PDF.com to remove the watermark A-PDF Split DEMO : Purchase from www.A-PDF.com to remove the watermark
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Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Jan 17, 2020

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Page 1: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

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Page 2: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Supported by:ASEAN-Australia Development Cooperation Program Stream.

Strengthening ASEAN Risk Assessment

Capability toSupport Food Safety

Measures

2007

Technical coordinator: FSANZ Australia

CHEMICAL RISK ASSESSMENTCASE STUDY

Prepared by ASEAN Countries

AFLATOXINS IN PEANUTS AND OTHER FOODS

CASE STUDY

Page 3: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Potency Values

HbsAg+• 0.3 cancers/year

per 100,000 population per ng aflatoxin/kg bw per day

• Uncertainty range 0.05 to 0.5

HBsAg-• 0.01 cancers/year per

100,000 population per ng aflatoxin/kg bw per day

• Uncertainty range 0.002 to 0.03

Source: JECFA

Page 4: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Exposure to aflatoxins from peanuts and other foods for ASEAN countries

Page 5: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Estimated cancer numbers in ASEAN countries

0.27 cancers/y/100,000 pop (Hep B)

0.009 cancers/y/100.000 pop (Non Hep B)

Page 6: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Food Group Number of

samples

Number (%) of samples

contaminated with aflatoxin

Range (mean) of total aflatoxin content

(µg/kg)

Bumbu pecel/gado-gado (peanut dressing, almost similar with sate sauce)

29 29 (100) 5 – 221 (25.5)TLC -AOAC Official

Method(LOD 5 ppb)

Peanut 141 141 (100) 1.7 - 124 (5.83)ELISA Methods

(LOD 1.7 ppb)

Aflatoxin B1 concentration in peanut and peanut sauce in Indonesia

Source: Ambarwati (2007) in ASEAN- Australia Development Cooperation Program Stream

Page 7: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Source: Ambarwati (2007) in ASEAN- Australia Development Cooperation Program Stream

Dietary exposure assessment on aflatoxin B1 in Indonesia*

*Food consumption data from Susenas 2004 (BPS, 2005); Average body weight 60 kg

Page 8: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

• 0.27 cancers/y/100,000 pop (Hep B)• 0.009 cancers/y/100.000 pop (Non Hep B)

Risk characterization of peanut and peanut sauce*

*Source: Ambarwati (2007) in ASEAN-Australia Development Cooperation Program Stream

Page 9: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

Food Type

PeanutsPeanut Sauce

Total dietary exposure (µg/day)

Total dietary exposure (µg/kg bw/day)

Aflatoxin concentration (µg/kg)**

5.8325.5

Food consumption (kg/day)

0.0033 0.0067

Estimated mean dietary exposure of aflatoxin

0.01920.1696

0.1887

0.0032

Dietary intake of aflatoxin B1 in Indonesia from peanut and peanut sauce*

*Sparringa (2008) based on food consumption data 2007; average body weight 60kg; 50 g peanuts in each portion of pecel/gado-gado/ketoprak

**Aflatoxin concentration as reported by Ambarwati (2007)

Food

Consumption

2007

Page 10: Appropriate level of protection ALOP available risk ......0 2 4 6 8 10 12 Assessed Acceptable Risk reduction delivered by available risk management options L e v e l o f r i s k ALOP

• 0.96 cancers/y/100,000 pop (Hep B)• 0.032 cancers/y/100.000 pop (Non Hep B)

Risk characterization of consumption of peanuts and peanut sauce (gado-gado, pecel and ketoprak)*

For Hepatitis B population 0.3 x 3.2 = 0.96 cancers per year per 100,000 population per ng aflatoxin per kg bw per day.

For non-Hepatitis B population:0.01 x 3.2 = 0.032 cancers per year per 100,000 population per ng aflatoxin per kg bw per day.

* Sparringa (2008) based on food consumption data 2007; average body weight 60kg; 50 g peanuts in each portion of pecel/gado-gado/ketoprak and aflatoxin concentration as reported by Ambarwati (2007).