Seminars in NEUROSCIENCE Spring 2020 Presented by the WVU Department of Neuroscience & WVU Rockefeller Neuroscience Institute “Noninvasive and Targeted Drug Delivery using Focused Ultrasound for Neurological Disorders” The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Transcranial focused ultrasound (FUS) is a targeted, noninvasive, and repeatable method for brain drug delivery that could enable improved treatments for various CNS disorders. This technique has the ability to facilitate the passage of therapeutics to the brain either by using microbubble cavitation to open the BBB (BBBO) or by using drug-loaded nanodroplets to uncage drugs with focal sonication without opening vascular walls. During this seminar, I will introduce both techniques, the BBBO and the ultrasonic drug uncaging for brain drug delivery, and share my experiences of using the BBBO technique for glioblastoma treatment and using the ultrasonic drug uncaging method for achieving precise neuromodulation and neuroimaging in preclinical models. I will then conclude my talk by sharing my future research goals. Thursday, January 16, 2020 2:00 PM Room 301 Biomedical Research Center (BMRC) Muna Aryal, Ph.D. Postdoctoral Research Fellow Department of Radiology Stanford University
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Seminars in NEUROSCIENCESpring 2020
Presented by the WVU Department of Neuroscience & WVU Rockefeller Neuroscience Institute
“Noninvasive and Targeted Drug Delivery using Focused Ultrasound for Neurological Disorders”
The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Transcranial focused ultrasound (FUS) is a targeted, noninvasive, and repeatable method for brain drug delivery that could enable improved treatments for various CNS disorders. This technique has the ability to facilitate the passage of therapeutics to the brain either by using microbubble cavitation to open the BBB (BBBO) or by using drug-loaded nanodroplets to uncage drugs with focal sonication without opening vascular walls. During this seminar, I will introduce both techniques, the BBBO and the ultrasonic drug uncaging for brain drug delivery, and share my experiences of using the BBBO technique for glioblastoma treatment and using the ultrasonic drug uncaging method for achieving precise neuromodulation and neuroimaging in preclinicalmodels. I will then conclude my talk by sharing my future research goals.
Thursday, January 16, 20202:00 PM
Room 301 Biomedical Research Center (BMRC)
Muna Aryal, Ph.D.Postdoctoral Research Fellow Department of RadiologyStanford University
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