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Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries
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Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Jan 01, 2016

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Page 1: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Antonio FasanoDipartimento di Matematica U. Dini, Univ. Firenze

IASI – CNR Roma

A new model for blood flow in capillaries

Page 2: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

A. FASANO, A. FARINA, J. MIZERSKI.

A new model for blood flow in fenestrated capillaries with application to ultrafiltration in kidney glomeruli, submitted

Page 3: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

• 7% of the human body weight,• average density of approximately 1060 kg/m3

• average adult blood volume 5 liters• plasma 54.3%• RBC’s (erythrocytes) 45% • WBC’s (leukocytes) 0.7%• platelets (thrombocytes) negligible volume fraction

Blood composition

Page 4: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Volume VRBC 90 μm3

Diameter dRBC 78 m

RBC’s properties

Very flexible

Page 5: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

the available fluid mechanical laws cannot be applied for a better understanding of the microcirculation in the living capillaries, and the hemorheology in the microcirculation requires another approach than regularities of the fluid mechanics

Quoting fromG. Mchedlishvili, Basic factor determining the hemorheological disorders in the microcirculation, Clinical Hemorheology and Microcirculation 30 (2004) 179-180.

Page 6: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

General trend:

Adapting rheological parameters to the vessel size

Page 7: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Our model ignores fluid dynamics and

considers just Newton’s law

Page 8: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Driving force

Pressure gradient

drag

Translating sequence of RBCs and plasma elements

The drag is due to the highly sheared plasma film

Translating element

Page 9: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Driving force

Pressure gradient

drag

Translating sequence of RBCs and plasma

The drag is due to the highly sheared plasma film

Translating element

a/R 1/3 when the hematocrit is 0.45

Page 10: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

If the capillary is fenestrated the plasma loss causes a progressive decrease of the element length

Page 11: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

The renal glomerulus is a bundle of capillaries hosted in the Bowman’s capsule

fenestrated capillaries

Page 12: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Plasma cross flow is caused by TMP (transmembrane pressure):

TMP = hydraulic pressure difference

minus

oncotic pressure(blood colloid osmotic pressure)

Page 13: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Element volume Vel = R2a + VRBC

Hematocrit el

RBC

V

V )(

1RH

R

a

3)(

R

VRH RBC

R

Page 14: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

elel pRkuuVdt

d 2

The motion of a single element(Newton’s law)

Variable owing to plasma loss

Friction coefficient

Pressure drop

elRBC pRkuu

dt

dV

2

density

Page 15: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

A guess of the friction coefficient

0 Take = 0.45

0uu = 1 mm/s

0x

p

0= = 40 mm Hg/mm

in the steady state equation

0k 610 = 8.8 g/s.

Page 16: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

in a 1.5mm capillary there are about 200 of such elements

It makes sense to pass to a continuous model

elpx

pLel

)( RBCV

u

xu

t x

pRuk

3)(

1

)(1

)(

R

hRH RCBC

elL

R

Divide by elL

Page 17: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

0

uxt

)( RBCV

u

xu

t x

pRuk

3)(

1

)(1

)(

R

hRH RCBC

elL

R

Conservation of RBCs

Momentum balance

To be coupled with a law for plasma outflow …

Page 18: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Balance equation for plasma

Starling’s law

C = albumin concentrationRTC = “oncotic” pressure (Van’t Hoff law)

constant

external pressure

Page 19: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Dimensionless variables

0k

k

L

x (L 1.5mm)

ct

t

0u

Ltc convection time 1.5 sec

0u

uv

L

pp e

0

)(

)()(

0

Page 20: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

vv

vt

t

c

k )()(

Momentum balance

0k

Vt RBC

k

stk

610

inertia is negligible

v)(

Page 21: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Combining the RBC’s and plasma balance equations

or

baa 0

Page 22: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Introducing the “filtration time”

we get the dimensionless system

compares oncotic and hydraulic pressures

Page 23: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

can be estimated, knowing that the relative change of during the convection time is 1/3

The case of glomeruli

We are interested in the (quasi) steady state

Page 24: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Eliminating …

Page 25: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

A second order ODE

Cauchy data:

Page 26: Antonio Fasano Dipartimento di Matematica U. Dini, Univ. Firenze IASI – CNR Roma A new model for blood flow in capillaries.

Experimenting with various friction coefficients and Os