Antiviral Drugs. Mechanism of Action Picornaviruses eg, polioviruses, cold viruses Block attachment molecule on host cell or pathogen Attachment antagonists.

Antiviral Drugs

Mechanism of Action

Attachment antagonists

arildone

Block attachment molecule on host cell or pathogen

Picornaviruses eg, polioviruses, cold viruses

Inhibit viral uncoating

Amantadine, rimantadine

Prevents viral uncoating

Influenza A virus

Mechanism of Action (cont.)

Inhibit nucleic acid synthesis

* Acyclovir

* Ganciclovir

* Ribavirin

Phosphorylation by virus encoded protein kinase activates the drug to inhibit DNA & RNA synthesis

Herpes, Epstein Barr, CMV, Varicella

RSV, HCV, Influenza A, hemorrhagic fever viruses

Mechanism of Action (cont.)

Inhibit nucleic acid synthesis

* Adenosine arabinoside

*Nucleoside analogs (azidothymidine

Phosphorylation by cell encoded protein kinase activates the drug to inhibit DNA synthesis

Herpes virus

HIV

Nucleoside analogues

Mechanism of Action (cont.)

Inhibit viral proteins

* Protease inhibitors blocks the active HIV site