Top Banner
f¾¾nf°$ -f¯ @f -f¯$ -f¯ °¾  f°°¾ °°¯¾f n° n , ¾ f° 9f n ¯ °f ° ° ¾ f¾ f° ¯f°f°¯½¯f¾½ff° °n°nnfn°¯f¯¯°¾° nf¾f½°f½°fnn¯f° ¯f°f°°¾°¾ nn ,f°f¯°n°n¯½nn¯f¯f°f° ¯½¯f°#¾¾%f°° n¯°f°f°¾ nn½¾½ °¾-½nf°f°-f°¾n½° ¯f¾½°½°¾°¾¾%nnn½ °°¾½nn@9D@@f ½nf°n¾½fnf¯f°f°°¾¾ ¯¯°¾½½¾¾f°fn°°¾¯f¾¾ ¾¾° ¯n n¯f½f°¾f½¾fnf°n ¾f f¾°%¾½nnf¾f f°°¯¾fnff¯f¾¯f¯f¾ fff°°½nf°¾¯f ¯n°¾°°n¾½nn ¾ ¾°f¾ff¯°ffnf°n¾ °n°@¾nfnf°nnf°n ¯½¯f°¾-°°¾% ¾¾ ¾fn¯f¾°n¾fn¯f%°nf°n° nf°nnfnf°nfnf°n ¯½f ¾¾f¯½¯¯fff°nf°n nnf¾°f¯f°f°¯¯f fn¯¾f Dfn,¾f ¾¾°¯½fn¯f°f°n¾¾n°° °¾¯½¯f - ¾ nf¯¾° -D-D f ¾¾°f¯°¾f½¾f° nf°n%°n°¯f¯f ¯¯¯¯fn¯f¯½ ¯¯f¯½¯f%°¾°°° -D¾¾¯¯¾¾°n°©°n°f °f°¾%@°¾¾n °°@@°¾°n nfn-D°°n¾f ½ff-½fn½°¯f° °¾n¾¾°°- ° - n¾° nf¯¾° ½½¾f° ¯½ f Jf ¾ ¾ ° f ¯° ¾ f ½¾ f ° nf°n%°n°¯f¯f ¯¯¯¯fn¯f¯½ ¯¯f¯½¯f%°¾°°°
20

Antineoplastic Drugs (Pharmacology)

Apr 06, 2018

Download

Documents

Yna Paez
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 1/20

f¾¾nf°$

-f¯

@f

-f¯$f°

-f¯

°¾

 f°°¾

°°¯¾f

%¯nf¯°n

,¾f° 9fn¯°f°f½°#¾¾f¾f°

¯f°f°¯½¯f¾D¾½ff°°n°nnfn°¯f¯f¾¯°¾°

nf¾%½f½°f½°fnn¯f°

¯f°f°°¾°¾

nf¯n f° ,f°f¯°n°n¯½nn¯f¯f°f°

¯½¯ff°°#¾¾f¾%f°f°°

n¯°f°f°¾

nn½¾½f¯ f° °¾-½nf°f°-f°¾n½°

¯f¾½°½°¾°¾¾%nnn½f¾

°°¾½nn@9D@@ff½

½nf°n¾½fnf¯f°f°°¾¾f¾

¯¯°¾½½¾¾f°fn°°¾¯f¾¾

¾f¯¾° ¯n n¯f½f°¾f½¾fnf°n¾f

f¾°%¾½nnf¾f

f°°¯¾fnff¯f¾¯f¯f¾

fff°f°°½f¾nf°¾¯f

¯nf¯°¾°°n¾½nn

¾f¯ ¾°f¾ff¯°ffnf°n¾

°n°@¾nfnf°nf¾nf°n

¯½¯f°¾f°-°°¾%¾¾

¾fn¯f¾°n¾fn¯f%°nf°n°

nf°nnfnf°nff°nf°n

¯½ff° f° ¾¾f¯½¯¯ff°ff°nf°n

f°nnf¾°f¯f°f°¯f°¯ffn¯¾f Dfn,¾f ¾¾°¯½fn¯f°f°n¾¾nf¾°°

°¾¯½¯f

- ¾f¾

nf¯¾° -D-D

f

¾¾°f¯°¾f½¾f°

nf°n%°n°¯ff¾¯f

¯¯¯f¾¯ff°f¾n¯f¯½

¯¯ff°¯½¯f%°¾f°°°°

-D¾¾¯¯¾¾°n°©°n°f

f°°f°¾f¾%@°¾¾n

f¾°f°°@@°¾°nf¾

nfn-D°°n¾f½ff-½fn½°¯f°

°¾f°n¾¾°°-f°°f°

-n¾°

nf¯¾°

½½¾f°

¯½f°

fJf ¾¾°f¯°¾f½¾f°

nf°n%°n°¯ff¾¯f

¯¯¯f¾¯ff°f¾n¯f¯½

¯¯ff°¯½¯f%°¾f°°°°

Page 2: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 2/20

-D¾¾¯¯¾¾°n°©°n°f

f°°f°¾f¾%@°¾¾nf¾

°f°°@@°¾°nf¾nfn

-D°°n¾f½ff

-½fn½°¯f°

°¾f°n¾¾°°-f°°f°

-n¾°

¯¾° -D-D f°¯¾¾¾f°f½¾°¾

¾f¾°nf°n,f°f°¯f°¯f

¾½n° f°¾f ½n°°¾f½½Df°

¯°¾f°%f°¯f¾fnnf°n

½f°nfn¾n¾

 f°°¾

ff¯° f°¾¾ffnff°nf°n

¾°n°¾f¾°f¯°nf°

¾f¾¾fff½f¾f¾ff°f

°¾¾nf°¾¾f°fnff°nf°n

nf½f° 9ff½f° n¯f½¾ff°¾¾¯¯¾

nf°n%¯f°ff°nfn°¯f°ff°°n

nf°n¾

n¾½f° 9f° ¾¾ff¾½¾nf°n¾

°n°¾fn¯f¾¾¯nfn°¯f¾%¾¯fn°

nf°nf°ff°nf°n¯½¯f¾f°¯n

¯¾

fnff° @ D¾°f¯°f¾nf°n¾f¯°

¯¯f°f°¯f°¯f°

¯½¯f¾fn¯ff°¾nnfn°¯f½f°nf¾

f½f° f° n°f°n¯½f¾¾°

nf°nn¯f½

½½¯f° In

½f @½ D¾fnf°n

 °f¾

¾f° ,f° ¾¯f°¾¾f°°¯ff°¾½f°f°

¾½nf°n°n¯°¾¯f%,

¾¾f¾fn°°°¾¯nf°¾¯fn°ff°½n¾f°°

f°°°f¾f°n¾¾°¾@¾nn¾

f°-fn°°n

f°n½nf°°-ffn¾nf°

f©fn°¯¾ff°½@¾°

f¯fnf°°½fnf¯fn°f°

¾n°¾f½½¾¾¾¯f°¾¾f

Page 3: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 3/20

°°¯ff°¾½f°f°¾½nf°n°n

¯°¾¯f%,¾¾f¾f

n°°°¾¯nf°¾¯fn°

ff°½n¾f°°f°°°f¾f°

n¾¾°¾@¾nn¾f°-fn°°n

f°n½nf°°-ffn¾nf°

f©fn°¯¾ff°½@¾°

f¯fnf°°½fnf¯fn°f°

¾n°¾f½½¾¾

 °¯f¾

nfnf°f°¾ ¯ff°f¾¾½¾°f°f

¾f¾nf¾°nf°nf°n¾nfn

f¯°¾

¯f ,@O

f¯½°

,f

D¾n¯f½f°°n¯°f°

f°¾¾nf¯°f

°¯nf°n¾°n°f¾ff°

°n¯f¯½¯f°¾¾fn¯ff

f°½f¾n°½f¾¯¾

½¯¾¯ ¯f ,f°f°½f¯¾¯f°n¯°f°$

n¾½f°nfff°n¯f¾fn°°¾¯f

n°nf°nf½n¯f½

9¯°°f¾

ffn° Iff @f¯°¯¾½f¾n¾°¯¾½¾

fnf°¯ffnf°¯f$°

¾f¾¾%fnn¯½f°

°½°f¯n½°f°

f°¾¾°¾fnf°¯f$n¾¾f¾¾

fnf°¯f$n¾¾f¾¾°f°¾¯f°

n°n¯¯°nn¯fnf½nf° Of ff¯°¾n¯f½nf°¾°

f¯°¯f¾fnf¾f°nnfnf°n¾

f½nf°¾f½f¾°¯fnf

n°fn°¯

°¾-¾°¾¾f°¾¾¯¾¾

nff° ¾fD ¯f½f°¾¯f°°f̄ °

nf°n¾n¾¾nf¾fn¯

¯f%,f°°°°¯½¯f¾f¾

°°f¾f%f°f°¾°¾¾

nf°nn¾°°-¾°¾¾

° D @¾¯¾°¾°f¯°nnfnf°n°¾nf¾¾°

°°¾fn¯n¾¾f¯

f¾f¯ffn

fn Dn @n¯f½f°D%fnnf¾

°°¾ff°¾nf°nff¾fn¾°

¾ff¾½°n½ff¾f¯f¾°f¾

°°½°fn°¾°¯n¾

Page 4: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 4/20

¾°¾¾½¯°¯°n¾f

°n¾-½nf°@¯f

¾°f¾¯f¾°¯°½¾½f

%D,9°¯°¯°½¾½f%@,9

¯°¾f°Dnf¾¾f¾nfn°@,9¾

f½°nf°n¾n¾°nf

f¯°¾¾f

¯nf° ¯f ¯nf¯nf°¾f°n¾f°f°n

°f¯¾°nf°

n°f½fn°f¯¾

¯nf°¾¾°f¾nfn°¯f¾°°¾¯f

n°nf°n½f°nfnnf°nf

nf°nf°f¾nf°n¾°°¾f¾

°¾½ffnf°nf°¾¾½¯°f

°¯½¯f¾f°f¾¯½¾

¯nf°½¾°¾f°ff°n°½f°nfnnf°n

nf¾f¾°f¾f°f¾¾¯¯¾

n¯f½½nff° ,ff° f¯°°¾¯½¯ff°

nf°f°nf°n¾%¾nf¾f¾¯f¯¯

¾f¯¯f½¯n°¾nfff°

f°¾f°½½°@¾

¯ff°fnf°f¾

°¾,¾°nf¾°n¾

¾¯½f¯¯n¾@¾f°f¯°

°ff° f°° ¾°nff¯°½f°¾@n

fn¯½f¾n¯ff°@n

¯½f¾n¯½¯f¾¾f¾f¾°

¾½°f¾f½¾°f¯°ff¾n¯f½¯°¾

9°°f¾

nf° ¾f° D¾ffn¯f%¯n

n°¾¾f°¯½¾n¾¾¾n¯nf

°f¯¾nf°¾°%

nff° f

ff° ff ff°¾n°f¯°n°n

¯½nn¯f½n°¾½°¾f¾

f°ff°f°¾¾nf¾nf¯nf°

ff°°¾-¾°¾¾°°

°nnf¾f°-½¯f¾̄ nf½½° ,99° ¾¾f ̄f½fn°°°¾

¯½¯f½n¯ff½¾fnf¾f°

°f¯¯f¾f¾%¾nf¾°¾

¾f¾f°nfn¾

f°° f°¾ ¾½°n½f¾¾°fnf¯f¾f°n°n

¯f¯ff¾°°¾f¾°

f¯°½¾f¾¾

Page 5: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 5/20

°n

nf¾°¾

f f @f¯°¾¾¯n¯f¾n¾¾°¯nf°¾¯

fn°¾f¾°¾n°

½n°°n¾f°°

°¯°nnf¾¾nf°°¾

fnf¾f¾f°°n°-9¾

@¯f

n°f

-° f¾°¾n°°

f°½°¯n¾¾½°¯°ff¾°

°¾f¾°f°¯¾fn¯f¾f

¯f%,@Of°ff¾fnff°¾

f°¾½n°,@O¾¾f°¯n¾f

n¯fnf°°ff¾¾f°n

¯f¾¾°n¾°¯½¯f

n¯n° 9°¾f°

-½°

¾nf¾¾f¾f½°f°fn¾f½

f°¯f¯¯n¾

°n¾f°¾°f°¾°¾

°¯f°¾°f¯°f¾°°n¾f½n¾¾-

f°nn¾°f¯

°f°fn¾-¾°°n

¾°%¯¾¾f°¾nf-f

½n¾¾¾f¯nnf°nn¾f°

fn¾9°¾f°¾¾ffn

¯f¾°°f°¾°¾°°n

¾¾¯°¾

°¯°¾

½°¾f° -½° ¾nf¾¾f¾f½°f°fn¾f½

f°¯f¯¯n¾

°n¾f°¾°f°¾°¾°¯f°¾°f¯°f¾°°n¾

f½n¾¾-f°nn¾°f¯

°f°fn¾-¾°°n

¾°%¯¾¾f°¾nf-f

½n¾¾¾f¯nnf°nn¾f°

fn¾9°¾f°¾¾ffn

¯f¾°°f°¾°¾°°n

¾¾¯°¾

,n°¾

°nfff¾ D¾°f¯°nf°n@ffnf¾¾n

nn¾½nnnn¾n°°fnf°nn¾fn°½°°

½°¯¯°°¯n¾f

°n¾¾fn¯½°°nf¾°I°nfff¾

f°½n¾°nff°¾f¾¾°

nf°nf½f°f¾¯¯°¾½½¾¾¾

°f¾°¾f If° D¾°f¯°nf°n@ffnf¾¾n

nn¾½nnnn¾n°°

Page 6: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 6/20

fnf°nn¾fn°½°°

½°¯¯°°¯n¾f

°n¾¾fn¯½°°nf¾°

°n¾°¾f °n° I°n¾°¾f°f°¾°¾°¾°

f¾½¾n¯f½¯°¾¾¯f°¾¾

f°°°°¾¯½¯ff¾½f

n¯f½¯°9°¾¯½¯ff¾

½f,999999¾¾

½½ff°In¯f½¯°°fn

¯½f¾n¯ff°°f¯°

°½f¾¯f

°n¾°%½¾¯f ,f °n¯°f°f½̄ °fn¯f

°#¾¾f¾¯½¯f¾°n°#¾

¯½¯f

°° -f° I°°¾f½½f¯°-°¾¯f

n°nf°nf°,f¾fnf¾nf°n¾f¾

fn°f¯¾fn¯f

 °¯n¾

@ff°¾

nf @f ¾¾¯f°f¯°f¾ff°

½¾ff°°°¾¯fn°nf°n

½fnf @f D¾f½f°¾°ff°f¾nf°n

ff°°nnf°nf°ff°n¯¾f½¾¾

¾fn¯f9fnf¾f¾¾½°°

¾°¾¾

 °¯°n¾

¯n°¾f °f° @¾¾°f¯°°¾

¯½¯f%f¾fn¯½°°

I¯°¾f¯¾nnfn°¯f¾f°¾nfnf°nf¾f¾°f¯°

½f°ff¾f°f¾f¯f°¾n°½¾¾

fn°¯n° n°¯n°

¾¯°

n°¯n°¾½¯f¾f¾f°°¾f°

n°f°¾n½°¾¾

°°-ff°¾n½°°f°n¯½f°

½°°°f°-½¯f¾nf¾

nf°°-½¾nf°f¾°-

½nf°fn¯nf¾¾n

f¾ff¾¾°ff

f¾°¾-¾°¾¾

f°n° ° ¾¾¾½¾nf°nn¾°@f¯°¾¾f½¯

n¯f½¾%¾nf¾nff°f°¾

f¯°¾f°½°¾°½¯f°

¾½°¾

f°n°

%½¾¯f

f°O¯ fn¯f½f¾f½½

fff½¾¾¾fn¯f¾f¾n¯¯°

¾f¾½nn½¾f¯ff°°°°

Page 7: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 7/20

¯½¯f½¾¯ff°n°¾°f°¾

f¯°¾

n° f ̄n° n°°fn¾-°nff°f°

°°¯fn¯nf¾°¾¾@¾°¾

½¾¾°°¯½¾¯f¾n

f¾¾½n¾°-f°¾n½°n°

¾f¾½¾¯f¾n¯½ff¾

°-nf°½nf°½°°

-¯°¾ff°

¾½½°½n¾¾½nf°

%½¾¯f

f

,n

f¾½ff½¾¾¾fn¯ff°

fnf°nfnf¾¾¾°¾°¾°

°°°¯°¾f°f°

f°¾@½°nnf°¾¾°

½°fn°n°f°°¾°

½n° °n ½n°¾½¯f¾ff°¾f¾f°ff°

nf°nf¾nnf°n°nf°nf°¯½¯f¾

fn° f¯n° ¾°f¯°fn¯¯f

¯¯n° ,f¯n° ,¯n°¾f½°-n¾¾°¾°

n¾¾°½°¯f¾¾°n°°

fnf@¾¾fnn¯½¾nfnf°

-ff°¾

¯f°° -f°° ¾¾°f¯°nf°½¾nf°n

¯¾¯f¾fnf¾nf°nfn¯¯f

f°°°°¾¯½¯ff¾f¾¾°

¯½¾fn°¾°¯¾

f½¾fn¯½f¾nf¯f

½nf¯n° ,fn° 9nf¯n°f¾°¾°f¯°¾nf

nf°n

9f¾¾f¾°f°f¯f°f¯°½nfn¯f9nf¯n°f¾°

¾°n°n¯¯f9nf¯n°¾

n°¾°¯½ff¾¾fn°n°

nf°nnf½½¾¾f°f¾f¯f¾f¾¾°

fn° If¾f D¾ffnf°nIfn°¾f

¾¯¾°nf°ff°fnn°n°

f°¾f¯°¾°¾°n°f

@f@f½¾

 °¾

f° @f° f°nff¯°nf°¾

¯f°¾f°¾nf°¾@n¯½¯f°½f°¾ffnff¾°½¾¾¯nf½

f¯ @f¯ f¯°¯f°¾¯½¾¯%@½

f°¯½¯¯f

°f¯

%f

¯ D¾°n¯°f°$f¯f¾°

f¯°¯½¯¯f½f°¾f

nff¾½f½

 ¯°¾ ¯°f

Page 8: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 8/20

 °f°¾¾f°

°¯¾

 °°¾

¾fn° @¾fn

½¾° ¾

¯°f ° f°¾ ¾

f°°¯¾

f¯°¯ f° ¾°nf¾½½¾¾°f°f°n°°

¾n½f°¾¾°¾¾°¯,°°

¾½f¾¯fn¾°½f°¾f°f

nfn°¯ff°n½n@½n°¯¾

n°fff°f

½f¯°¾f°°½f°¾f°f

½½f¾ff¾½f¯°

¾°¯°¾f½f°

f°f¾ ¯ @f¯°ff°nf¾nf°n°½¾¯°½f¾f

¯°©f°f¯°½¾¯°½f¾f¯°

$¯°n½+f°f¾f¾nf°n

°ff¾nf°n°¯°n½+

½¾¯°½f¾f¯°fn

f©f°f¯°

nff¯ f¾ f°n½¾fnf°n°n¯°f°$

f°ff½¾nfnf¾f°

¯¾f° ¯f¾° ©f°f¯°½¾¯°½f¾f¯°$

¾°n½+°°°ff¾nf°nn°ffff¾nf°n¾°f¯°¯°

n½+ff°nf¾nnf°n%°$

°f¯°½¾¾¾f¾°f°

¾°f½f°¯½¯°ff½¾°

¯°$°ff$°n½¾¯°½f¾f¾f¾

f¯ ° @f¯°½f°¾$ff°n½¾fnf°n°

n¾½½¾¾°¾¾°n¾¾°nf

°ff¯°°n¯°f°f°f

°n°©°n°$nn¯%fn°

f°°¾f¾f¾½f°¾fff°

f$f°f¾f°°¾nf¯f¾¾f¯°

½f°¾°¾½°¯¾

°n°f¯°¯°n°

f¯°¾°ff°n¾¾

¾f° f¾ @f¯°½¾¯°½f¾f¯°$¾°

n½+nfff°n¯f¾fnf¾

nf°n¾f¾f½¾°ff©f°

Page 9: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 9/20

f°¾°f½¾f¾½¾¾°°f½

$f°f°¾°

¾°fnf f ,f°f¯°½¾ff¾nf°n°

½¯°½f¾f½¯°½f¾f¯°¾f

¯°f¯f°½f°°¯¾¾°¯f

°°°°n°©°n°$f½°¯fnf

¯½¯°f°¯n½f°¾$°¾½

½f¾¾¾½n°

¾°fnf

¯½f°

If°f¾ ¾°nf°½fff¯°

ff°n½¾fnf°n

¯ff ¾°f¯°°½¾¯°½f¾f¯°$

¯°½°°ff°nf¾nf°nf°n

f¾nf°n°¯°$°fffnf°n

½¾¯°½f¾f¾f¾f½¾°

f$f°¾°¾9½f½°

½¾¯°½f¾f¯°$nf¯°n½

+f¾nf°nf¾¾°f¾n°¾°

¾°f©f°f¯°ff¾nf°n°½¾¯°½f¾f¯°fn

½¾f°ff©f°f¯°f½

½fnf ½°

¯¾fnf ,fn

¯f° ¾° °nf°f¯°°½ff°fnnf

nfn°¯f°n°ff°°°°n°f½¾

°f¯ -f°° °nf¾°n¯°f°¾nfnf¾f°f¯°¯f¾fn½¾fnf°n%f

¯f¯¯°---f¯°¯¾

°°¾f¯ff¾°ff¾nf

nf¾f°

½¾f

½¾½f

¾f°

n

¾f °nfn°°¾°f¾f¾

nf°n°½¾¯°½f¾f¯°f¾°f¾

f¾nf°n

f¯°nf%°°¾f

f°¾°

-f f̄ °f¾nf°n°f°

¯° f¾° ¾°nff¯°¯f¾fnf¾

nf°n°½¾¯°½f¾f¯°¾°

n½½¾°°°¯¾

,¾nf°¾

°¯¾

Page 10: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 10/20

f¾½ff°f¾ ¾½f ¾°nff¾fn¯½°°f¯f°

n¯f½n¯°f¯°½f°¾

fn¯½f¾n¯f%

½f¾½ff¾ °nf¾½f ¾°nff¾fn¯½°°f¯f°

n¯f½n¯°¾°f¯°

½f°¾f°½¾°¾f¾½ff°f¾

nf@f½¾

   °¾

°°f½ff

n¯°f°

°- ¾°nff¯°n°n½f¾f°

fn¯f°½f°¾f¾f°

f°¾°nfn°n½f¾9f½f

n¯¾¯%9½¾n°n¯°¾

¯f%,½f°¾f¯°¯f½f

%°ff°¾¾

°°f½f

n¯°f°

°°-f½f

°°

f¾° 9° f¯°,f¾fn¯f°¯f,f¾fn

°fnnfn°¯f,°n°f

 °¾

I fnn°¾

;ff°¯f°

½f½¯f¾%@½¾

n¯°f°fnn°

ff¾ 9°°nnfffnf°n½¯f°f°

°f¾°¾%nnfff9I°n°

nnff°nfn°¯f°¾  %°f°f

f¾% °¯ffn¯°f fnf¾ff9I½¾°¾¯°

¯f°½f½¯f¾

fnn°

f©f°f¾

f °¯f¾¯½°°½¾¾°

°n°½¯f°f°nnf¾°¾nnfnf°n

nf¾9I½¾

-¾°¾½°¾¾

@-D99,%@O-

,-@

O ¾¾¾¾n¯½n°%°ff°½fn°¯f½¯f

nn½fn°¾½½¯°¾

O °n½¾nff¾¾¾¾¯°n¯°°°¾

O ¾¾¾¾¾¾½¯°f°n°¾¾n¾ff½¾f°°ff°°n°

¾¾°f½

O ¾¾¾¾¯½f¯ff°f¾°°n°

Page 11: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 11/20

O ,°ff°ff°½

-D--

O ¾°n°f°¯f½¾¾°

O ¾¯ff°n°°¾¾f°¯°¾f¾n¾

n¯f½

O ¾¯½f°f¯°f°f¯fnn¾¾nf¾n¯f½

O ¾f°¯f°fn¾n¯f½°°°f

f°$°¯f½¾¾°

O n°°%½f°$f¯$nf¾fn¯f½n½n

O ¾¾f¾°n°f°°n°¯f¯°¾fnn%°¯f¾

fn¾½¯½n°%°¯f¾

O ¾¯fff°°°f°$¾¾

9---

O °fnnf°½fn°¾°¾f°

O °¯f°¯°n°

O °¯f°f°°°f¾f¾%ff°ff°½¾n°nfn°f

¾f

O °¯f°f°ff°f½

O °¯f°¾¯½¯¾¯fnn¾¾

O °$f¯$nf¯°¾f°¾f°°n¯f½n½n%

¾f¯°¾f°¾n¾f¾fn°¾

-D--@I-@-

O ,°n°¾f°fff¾

O f°nf°½½ff°f°f¯°¾f°fn¾°f°¯n¾

¯¯f°n°fnf°nf°n¾½n¾

O ,°I¾°f°f°½¾

O ¯°¾f°¯n¯°¾°

O fn°If°$f¾n¯f½¾f¯°¾

O ,°f°°%D-f°nf°°½f¯°¾f°

O ¾¾¾¾¾°¾f°¾¯½¯¾¯ff°f°n¾f@fnn°

¯½f¾

O °nf¾¾$fn¾¯fnn¾¾f½¾°nfn¾

¯f°

O ,°°ff°½f°°°f°f

O ,f°f°¾n¯nff¾½¾¾°¾¾°nf°¾f°°f¾½n¾

O °fn°

4 °f

Page 12: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 12/20

¯½f¾½n½nf°¾f¾°n¾¾f%f°f¾°½¾°f

°

@fnn°fnn½¾½f¯f°f½°fnn¯f°

°f°°

¯°n°n°¾ffnf½f¯°¾f°

f°fnn°¾

¾n°fnn½¾½f¯¾n°f¾¯@¾nf

f½f°¾¾½¯f$f¾½¯f¯fnn°¯f¾

@fn¯½f°n¾°n°¯f¾¾f¾f½½½f¾n¾¾

¾½¯f°°¯fn°¾f¾f½½½f

@fnn°f½°f°n¾f¯°¾fn¯½°

f°°½f¾nf½°¯¾¾f°¾¯¾n¾n¯¯°f

¯°f°¯°fn°n½°f¾fn¯½°f¯°

¾n°°¾f°°f¾f¾½f°n°nf¾

Jn°½¾n°f¾fn°f°°n°

°¾nn°½¯½½¾°¾°n°%f¯½f

n¾¾f°nf°$°°°°f°

°¾¾$¾°$½f°°ff°°%°¯¾½nf

¾¾¯ff°¾f°f°¯f%°nf¾f

¾½°f¾fn½°¾°

4 n¾

°¾nn°ff°f¾¾¾¯f¾

fn°¾f¾¾°½fn°¾$¯¯

¯°½¯°½f¾f¯f¾f¯f½°nf¯°f

¯°¾ff¾¾°¾n¯fn°¾f¯f

½°n¯½°n

¾n°½¾¾f¾¾n¯¯°ff½n¾nff°

¾¾¾¾¾f°f$n¯½¯°ff½f¯f°fn

n¯f½f°

4

¾n°f°½°¾%f°¯f¾f°¾½f¾

ff°

¾n°fnnfn

n°f°¾f¯fnf¾°f¾f%nfnfn¾

°f

9f°¾¯f°¯f¾

O f°¾f°¾

°¾¯°°J¾°nf½¾fnfn¾°¾f¯f

n°¾°¾¾f°f¯½f¾f°°°¯f°°f

n°¾¾¾f°¯n°¾°f°¾n¾¯nf

°¯f°¯fnf¾¾¾¾°nf½¾½fn°¾

f¯f°¾°f°fn°¾¾¯f¾

Page 13: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 13/20

°f¯¾n¾f¾f°¾¯°f°nff

½fnn¾f°ff°°°fn¯¯°nf°

½½¯°f°°f°f¯n¾fff¯°¾f°f¾

°½°nf°¯nf°¾°n°nff°½°f

¯f°¾f°½f°¾

ID@-

°f¾°n°

°¯f°f°f

°¯f°f°°°f¾f¾

°°½¯fnn¾¾

°$f¯$nfnf°°¾¯

;¾°¾f¾ff°¾

-@,@@DD%DD

,-@

¾¾¾¾n¯½n°%°ff°½fn°¯f½¯f

nn½fn°¾½½¯°¾

°n½¾nff¾¾¾¾¯°n¯°°°¾

¾¾¾¾°f°n°¾¾¾f°°f½

¾¾¾¾¯½f¯ff°f¾°°n°

-D--

¾°n°f°¯f½¾¾°

¾¯ff°n°°¾¾f°¯°¾f¾n¾

n¯f½

¾fn½f°%¯n¾¾$¾¯f¾f¾n¾n¯f½

¾¯½f½f°f¾°°fffnf¾n¯f½

n°°%n°$f¯fn¯f½n½n

9---

°n°¾¯f°°¾f° °¯f°f°°°f¾f¾%ff°ff°½ffnfn°f

¾f

°fff½f°n°

°¯½¾¾°

°$f¯$nf¯°¾f°¾f°°n¯f½n½n%¾

f¯°¾f°¾n¾f°f¾fn°¾

Page 14: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 14/20

-D--@I-@-

,°n°¾f°fff¾

f°nf°½½ff°f°f¯°¾f°fn¾°n°fn

f°nf°n¾½n¾

,°I¾°ff¾f°½n¾¾½f°¾nn¾f½½n½fnf°°fnf½

¯°¾f°¯n¯°¾½°¯°

¾¾¾¾½½¯°f°f°°°nDf¾f¯°¾

n°f°¾f¯fnf¾°f¾f%nfnfn¾°f

9f°¾¯f°¯f¾

,f°f°¾n¯nff¾½¾¾°¾¾°nf°¾f°°f¾½n¾

½½f°¾¾¾f°¾f°f¾¾

°nf¯°¾¾¾°¯f¾f°

,°°ff°½f°°°f°fn¾fn¯¯°°f

f¯° °fn°

4 °f

¯½f¾½n½nf°¾f¾°n¾¾f%f°f¾°½¾°f

°

@fnn°f¯°¯ff°½¾°¾¾¯f¾%¾°¾¾

nf°¾½fn¾°¯f°¾f¯¾ff¾

¾¾°f¾¯f¾nn¾°¾¯f°¾f°¯f¾f°

D¾f¾¾

°¾nn°f½f°¯nf°f¾½¾n¯½f°

f¯n¾¾$¾¯f¾ ¾n°ff°½¾°¾½nf°¾D¾¾°¾n°

°¾

¾n°°¾f°°f¾f¾½f°n°nf¾

n%Jn°½¾n°f¾fn°f°°n°

@fn¯½f°n¾°n°¯f¾¾f¾f½½½f¾n¾¾

¾½¯f°°¯fn°¾f¾f½½½f

@fnn°f½°f°n¾f¯°¾fn¯½°

f°°½f¾nf½°¯¾¾f°¾¯¾n¾n¯¯°f

¯°f°¯°fn°n½°f¾fn¯½°f¯°

°¾nn°½¯½½¾°¾°n°%¾f

n¾°f°n°°°°f°°¾¾¾°½f°°ff

°°%°¯¾½nf¾¾¯ff°

¾¾°¾f°¯f%°nf¾f¾½°f¾fn

½°¾°

4 n¾

Page 15: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 15/20

°¾nn°ff°f¾¾

¯n¾¾$¾¯f¾fn°¾f¾¾°½fn°¾

$¯¯

°¾°¾¯¾°¯f¾f°f°f¾

n¯¯nf¯f¾¾fn°f°fn

¯°½¯°½f¾f¯f¾f¯f½°nf¯°f

¯°¾ff¾¾°¾n¯fn°¾f¯f

½°n¯½°n

¾n°½¾¾f¾¾n¯¯°ff½n¾nff°

¾¾¾¾¾f°f$n¯½¯°ff½f¯f°fn

n¯f½f°

4

°nf¾¯f°¯f¾

°nf¾nf°¾

nn½¾n½½¾½¯½f°

f°¾f°¾

°¾¯°°J¾°nf½¾fnfn¾°¾f¯f

n°¾°¾¾f°f¯½f¾f°°°¯f°°f

n°¾¾¾f°¯n°¾°f°¾n¾¯nf

°¯f°¯fnf¾¾¾¾°nf½¾½fn°¾

f¯f°¾°f°fn°¾¾¯f¾

°f¯¾n¾f¾f°¾¯°f°nff

½fnn¾f°ff°°°fn¯¯°nf°

°°nf¾°n°n½½¯°f°f¾°½°f¾°°

½½½½¯°f°¯f¾°°¾°°f¾ff°f

¯n¾f@¾¾f¾f½½f¾¯

ID@-

°f¾°n°

f¯n¾ff¾¯ff°¾°

9f°f¾n°

°°¯f°°fn

°$f¯$nfnf°°¾¯

;¾°¾f¾ff°¾

-@@D,-@@OD-%,-

,-@

Page 16: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 16/20

¾¾¾¾n¯½n°%°ff°½fn°¯f

nn%J½fn°¾½½¯°

¾

°n½¾nff¾¾¾¾¯°f°n¯°°°¾

¾¾¾¾¯½f¯ff°f¾°°n°

¾¾¾¾½f°¾½°f°n%f½½½f

-D--

¾°n°f°¯f½¾¾°

¾ff°°nffn½fnfnn¾n¯f½

¾¯½f¾°°f¾nf°½½¾n¯f½

n°°ff°°½f¾nf½

9---

°¯f°f°nf¾°¾f° °nffn¾°n°

°#¾¾°°¯f°°fn

°$f¯$nf¯°¾f°¾f°°n¯f½¯°°n°

¾n¾

¾¾¾¾n°$f¯$nf°fn¯f½n½n

-D--@I-@-

,°n°¾f°fff¾

¾¾¾¾nffn¾f¾

f°nf°½½ff°¾fn¾°n°fn

,°I¾°n°¾f¾¾nf°¾n¾f°¯¯f

f½½f°ffn°°°I°¾°

@¾¾°n¾¾¯fnn¾f°f°°¾¾ff¾f°½n¾¾

½f°¾nn¾f½½n½fnf°°fnf½

¯°¾f°¯n¯°¾n¯f½

,°nf°¾°°n%½°@¾f°¾n°°

n°f°¾f¯fnf¾°f¾f%nfnfn¾°f

9f°¾¯f°¯f¾

¯°¾½½fnnf°n¾½°°n°

f°f¾n¾½f°f¾½¾n

,f°f°¾n¯nff¾½¾¾°¾¾°nf°¾f°°f¾½n¾

½½f°D¾¾¾D¾f°f¾¾

,°°ff°½f°°°f°f

°%f¯,¯$f@fn°

4 °f

Page 17: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 17/20

Page 18: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 18/20

ID@-

°f¾°n°

ffn°n°f¾¯f°f°

°f°f¯nf°°¾¯

n¾f½n° °$f¯$nfnf°°¾¯

,@@-@$9-@%I-I-@-%-I-

,-@

¾¾¾¾f¾°n°°½f°f°°n¯f½f¯°

¾¾¾¾n¯½n°%°ff°½fn°

,°°¾¾¯fn°¾f¯$

°n½¾nff¾¾¾¾¯°f°n¯°°°¾¾½nfff°n

°nnf¾¾¾f¾¯°n ¾¾¾¾¾°¾½½f°½f%°¯°¾¾°°°°¾¾¾¾½

°°¾½¾f½½°fnf°

,°°n°°¯n°½f¯ffn°¾½f°f°½ffn¾

@¾°n¾°%°n°f°°fnnf°f¾n¾¯f°nf¾¾n°¾½f°

¾¾¾¾¯½f¯ff°f¾°°n°

,°fn°n¾½f¾¯

¾¾¾¾½f°¾½°f°n%f½½½f

ff½f°$f¯$nf°f½

-D--

¾°n°f°¯f½¾¾°

¾n°¾½f°f°½fn¾n¾n¯f½

¾°©f°½fn¾n¾n¯f½

n°°ff°°½f¾nf½

9---

°¯f°f°nf¾°¾f°

°¯f°f°ff°n°

°°½fn¾°n°

°$f¯$nf¯°¾f°¾f°°n¯f½n¯°°n°

¾n¾

-D--@I-@-

,°n°¾f°fff¾

¾¾¾¾°n°

Page 19: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 19/20

¯°¾¾¾°fff¾½¾n

,°¾°¾½½f°½f%°¯°¾¾f°$°°°f°¾f°$

¾°¾¾¾¾¾½°°¾½f¾¾f½¾½fff

¾¾¾¾I¾nfI°n¾°%°n°¾f¾¾nf°¾n¾f°

¯¯ff½½f°ffn°°°I°¾°

¯°

@¾¾°n¾¾¯fnn¾f°f°°¾¾ff¾f°½n¾¾

½f°ff¾f°nn¾¾½°¾°¯¯f-fnf½½½f

°¯°¾¾f°f¾°°fff½

½¾nf°

¯°¾f°¯n¯°¾n¯f½f¾½¾n

,°°ff°½f°°°f°f

,f°f°¾n¯nff¾½¾¾°¾¾°nf°¾f°°f¾½n¾

°%f¯,¯$f@fn°

4 °f

¯½f¾½n½nf°¾f¾°n¾¾f%f°f¾°½¾°f

°f¾°n¾¾f

@fnn°¾°¾f°¾¯½¯¾°n%°¯°¾¾f°$°°

°f°¾f°$¾°¾¾¾¾¾½°°¾½f¾¾f

½¾½fff°f°n¾n¾½½¾¯f

f°f¾°½½f°½f

@fn½f°¾°¾¾n°$¾°¯%°¯°¾¾$°°f°¾

f°@¾¯ff¾f¾°f¾ff¯f°n¯½¾

@fnn°fn¯½f½nf¯fnn@fnff¯f°

°¾f¯°¾ff½¾n¯½

¾n°°¾f°°f¾f¾½f°n°nf¾

Jn°½¾n°f¾fn°f°°n°

@fn¯½f°n¾°n°¯f¾¾f¾f½½½f¾n¾¾

¾½¯f°°¯fn°¾f¾f½½½f

@fnn°f½°f°n¾f¯°¾fn¯½°

f°°½f¾nf½°¯¾¾f°¾¯¾n¾n¯¯°f

¯°f°¯°fn°n½°f¾fn¯½°f¯°

°¾nn°½¯½½¾°¾°n°%¾f

°%°¯¾½nf¾¾¯ff°¾

f°f°¯f%°nf¾f¾½°f¾fn½°¾°

4 n¾

@fn½f°¾°¾½½f°½f

@fn½f°½n°¾½f°f°f¯°f½f°

¾¾¾¾°f¾f¯°f¯°¾f°¯n¾f¾½¾n

¾½f°½¾¾f¾¾n¯¯°ff½n¾nf

Page 20: Antineoplastic Drugs (Pharmacology)

8/3/2019 Antineoplastic Drugs (Pharmacology)

http://slidepdf.com/reader/full/antineoplastic-drugs-pharmacology 20/20

@fn¯½f°nn°¯f¾¾¾n¾¾¾½¯f°°

f½½½f

¯°½¯°½f¾f¯f¾f¯f½°nf¯°f

¯°¾ff¾¾°¾n¯fn°¾f¯f

½°n¯½°n

¾¾¾¾¾f°f$n¯½¯°ff½f¯f°fn

n¯f½f°

4

°nf¾ff°ff°¯fn¾

n¾n°¾½f°

f°¾f°¾

°¾¯°°J¾°nf½¾fnfn¾°¾f¯f

n°¾°¾¾f°f¯½f¾f°°°¯f°°f

n°¾¾¾f°¯n°¾°f°¾n¾¯nf

°¯f°¯fnf¾¾¾¾°nf½¾½fn°¾

f¯f°¾°f°fn°¾¾¯f¾

°f¯¾n¾f¾f°¾¯°f°nff

½fnn¾f°ff°°°fn¯¯°nf°

¾f°¾¯ff°nf¾¾½°f¯ff°¾°¯

°f½½½ff°n¯°¾n°%

ID@-

°f¾°n°

°n°f¾¯f°f°

9½f°½f°nn

n¾f½n°

ff¾f°f°¾¾°n¾¾°nn

°$f¯$nfnf°°¾¯

¯

f°f°f9ff-

¯

°f¯½f9f-