PROTEIN SYNTHESIS INHIBITORSWork by targeting bacterial ribosome Mammalian (eukaryotic) cells have 80S ribosomes composed of 60S and 40S subunitsBacteria (prokaryotic) cells have 70S ribosomes composed or 50S and 30S subunits AMINO- GLYCOSIDESTETRA-CYCLINESCHLORAM- PHENICOL MACROLIDESLINCOSAMIDESStreptomycin Gentamicin Tobramycin Amikacin Netilmicin Neomycin Kanamycin Tetracycline Doxycycline Minocycline Demeclocycline Oxytetracycline Chloram- phenicol Erythromycin Clarithromycin Azithromycin Clindamycin Lincomycin AMINOGLYCOSIDESBactericidal Inhibit protein synthesis All bind irreversibly to the 30S ribosomal subunit and interfere with protein synthesis in susceptible bacteriaUsed to treat infections caused by several aerobic gram-negative bacteria Given parenterallyMechanisms of Resistance: oPlasmid-mediated synthesis of aminoglycoside –inactivating enzymes such as acetyltransferase, nucleotidyltransferase and phosphotransfe rase which modify and inactivate these drugsoChanges in the 30S ribosomal subunit resulting in decreased affinity between the drug and 30S subunitoDecreased membrane permeability
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