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8/8/2019 antigen specificity
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OLVGCIL ^PINGJGNGVW
Dw
Zilhovi~m,^
8/8/2019 antigen specificity
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Nblvilv~
GlvtbfynvgblNblvtgdyvgblIpgvbpiVwpi~D niaa ipgvbpiV niaa ipgvbpipotovbpiOlvgcil%pti~ilvglc niaa^gclgjgnolniNblnay~gbl
8/8/2019 antigen specificity
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Glvtbfynvgbl
Olvgcil~ oti ~yd~vilni~!smgnm nol glfyni^pingjgn geeyli ti~pbl~i ,Vmg~ ptbni~~ g~ noaaifgeeyli cilgngvw smgnmnbl~g~v~ bj iaodbtovgbl bj olvgdbfw ptbfynvgblolf vmi fiziabpeilv bj niaa eifgovif geeylgvw,Olvgcilgngvwg~ vmi odgagvw vb nbedgli ~pingjgnoaawsgvm vmi jgloa ptbfynv~ bj vmi Xgeeyli ti~pbl~iU
~yd~volni~# vmov oti geeyli cilgn oti oasow~olvgcilgn dyv olvgcil~ oti lbv lini~~otgawgeeylbcilgn! ic;mopvil
8/8/2019 antigen specificity
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,Nblvtgdyvgbl
,Jbtigclli~~,Ebainyait ~g{i,Nmiegnoa nbepb~gvgbl olfmivitbcilgngvw,Olvgcil ptbni~~glc olfpti~ilvglc
8/8/2019 antigen specificity
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I}bcilby~ olvgcil~I}bcilby~ olvgcil~ oti olvgcil~ vmov mozi ilvitif
vmi dbfw jtbe vmi byv~gfi! jbt i}oepai dw glmoaovgbl!glci~vgbl
! bt glkinvgbl,
Ilfbcilby~ olvgcil~Ilfbcilby~ olvgcil~ oti olvgcil~ vmov mozi diil
cilitovif sgvmgl ptizgby~aw lbteoa niaa~ o~ o ti~yav bj lbteoa niaa eivodbag~e
! bt dinoy~i bj zgtoa btglvtoniaayaot donvitgoagljinvgbl
O yvbolvgcil~Ol oyvbolvgcil g~ y~yoaaw o lbteoa ptbvigl bt
nbepai} bj ptbvigl~ -olf ~beivgei~ FLO bt TLO' vmovg~ tinbclg{if dw vmi geeyli ~w~vie bj povgilv~~yjjitglc jtbe ~pingjgn oyvbgeeyli fg~io~i
8/8/2019 antigen specificity
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IpgvbpiOl ipgvbpi ! oa~b hlbsl o~ olvgcilgn fiviteglolv ! g~vmi potv bj ol olvgcil vmov g~ tinbclg{if dw vmigeeyli ~w~vie ! ~pingjgnoaaw dw olvgdbfgi~ ! D niaa~ ! bt V niaa~ ,
8/8/2019 antigen specificity
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Vmi ipgvbpi ~ oti vsb novicbtgi~,
nbljbteovgbloa ipgvbpi~ ,agliot ipgvbpi~ ,
Nbljbteovgbloa ipgvbpi~ oti glvitonv sgvm vitvgotw~vtynvyti bj vmi olvgcil
Agliot ipgvbpi~ glvitonv sgvm vmi potovbpi do~ifbl vmigt ptgeotw ~vtynvyti bj vmi olvgcil
8/8/2019 antigen specificity
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Ionm D niaa olf V niaa g~~pingjgnjbt opotvgnyaotolvgcil ,
vmi D niaa tinipvbt -DNT ' jbt olvgcil olfvmi V niaa tinipvbt -VNT ' ti~pinvgziaw,
8/8/2019 antigen specificity
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DNT~ olf VNT~ f gjjit gl;
vmigt ~vtynvyti8vmi cili~ vmov ilnbfi vmie8
vmi vwpi bj ipgvbpi vb smgnm vmiw dglf,
8/8/2019 antigen specificity
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D N iaa~
DNT~ dglf ~baydai olvgcil~,Vmi dbylf olvgcil ebainyai~ oti ilcyajif glvbvmi D niaa dwtinipvbt%eifgovif ilfbnwvb~g~ ,Vmi olvgcil g~ fgci~vif glvb jtoceilv~smgnm oti vmil fg~paowif ov vmi niaa ~ytjonili~vaif gl~gfi o nao~~GGmg~vbnbepovgdgagvwebainyai ,Miapit V niaa~~pingjgn jbt vmg~ ~vtynvyti -g,i,! sgvmnbepaieilvotw VNT~' dglf vmi D niaa olf~intivi awepmbhgli~ vmov;
8/8/2019 antigen specificity
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D%niaa Ipgvbpi~
^ pingjgn Ipgvbpi~ tinbclg{if d wvmi D%ni aatinipvbt otiabnovif bl vmi ~ytjoni bj vmi olvgcil,Miti EMN niaa~ lbv tiqygtif,Vmi nmiegnoa lovyti bj Oc g~ ptbvigl !pbaw ~onmotgfi!agpgf,
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8/8/2019 antigen specificity
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V Niaa~
Vmi ~ytjoni bj ionm V niaa oa~b fg~paow~vmby~olf~ bj gfilvgnoa Vni aatinipvbt~ -VNT
Vmi VNT -bj oapmo"divo V niaa~' dglf~ odgebainyaot nbepai} fg~paowif ov vmi ~ytjonibj ~be i bvmit ni aanoaaif ol olvgcil %
pti~ilvglc ni aa-OPN ',
8/8/2019 antigen specificity
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V%Niaa Ipgvbpi~
^ pingjgnIpgvbpi~ tinbclg{if d wvmiV%ni aa tinipvbt oti bjvil abnovif gl vmi gllit!yli}pb~if ~gfi bj vmi olvgcil,olf dinbei onni~~gdai vb vmi V%niaa tinipvbt~ojvit ptbvibawvgn ptbni~~glc bj vmi olvgcil,Nmiegnoa lovyti bj Oc so~ eb~vaw ptbvigl~!dyv~bei agpgf~ olf cawnbagpgf~ pti~ilvif bl EMNebagnyai~,
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8/8/2019 antigen specificity
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potovbpi
Vmi potovbpi g~ vmi potv bj ol olvgdbfw smgnmtinbclg~i~ ol olvgcil ! vmi olvgcil%dglfglc ~gvi bj ololvgdbfw, Gv g~ o ~eoaa ticgbl -bj ?9 44 oeglb ongf~'bj vmi olvgdbfw#~ Jz ticgbl olf nblvogl~ potv~ bj vmiolvgdbfw#~ miozw olf agcmv nmogl~ ,
? , Jod ticgbl4, Jn ticgbl>,Miozw nmogl6, Agcmv nmoglsgvm bli zotgodai-ZA' olf bli nbl~volv -N A'fbeogl9, Jz ticgbl sgvm potovbpi
4, :,mglc ticgbl
8/8/2019 antigen specificity
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O lyedit bj zonngli~ do~if bl D%niaa ipgvbpi~oti nyttilvaw ylfit naglgnoa pmo~i vtgoa~ ocogl~vzgty~i~ ! donvitgo olf nolnit , Vmi~i ipgvbpi~oti oa~b gepbtvolvIpgvbpi~ oti bjvil y~if gl ptbvibegn~ olf vmi~vyfw bj bvmit cili ptbfynv~,Y~glc tinbedglolv flo vinmlgqyi~ cilivgn~iqyilni~ nbfglc jbt ipgvbpi~ vmov otitinbclg{if dw nbeebl olvgdbfgi~ nol di jy~ifvb vmi cili,
^gclgjgnolni
8/8/2019 antigen specificity
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Jbt gl~volni! gj o ptbvigl ~oepai g~ dbgaif!vtiovif sgvm divo%eitnopvbivmolba ! olf tyl gl^F^%POCI jbt vmi Si~vitl dabv! vmi ptbvigl~ otii~~ilvgoaawfilovytif olf vmitijbti nollbvo~~yei gv~ lovytoa vmtii%fgeil~gbloa
nbljbteovgbl,Vmitijbti! olvgdbfgi~ vmov tinbclg{i agliotipgvbpi gl~viof bj nbljbteovgbloa ipgvbpi otinmb~il jbt geeylbfivinvgbl,
8/8/2019 antigen specificity
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Ol vgci l% pti~i l vg l c n iaa
Ol olvgcil %pti~ilvglc ni aa-OPN ' bt onni~~bt w ni aag~ oniaavmov fg~paow~ jbtigclolvgcil nbepai}sgvmEMN bl gv~ ~ytjoni,
V%niaa~eow tinbclg{i vmg~ nbepai} y~glc vmigtV%niaa tinipvbt-VNT', Vmi~i niaa~ptbni~~olvgcil~ olf pti~ilv vmie vb V niaa~,
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8/8/2019 antigen specificity
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OPN~ joaa glvb vsb novicbtgi~;ptbji~~gbloa btlbl% ptbji~~gbloa ,
8/8/2019 antigen specificity
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P tbji~~gblo a OPN ~
Vmiti oti vmtii eogl vwpi~ bj ptbji~~gbloa olvgcil%pti~ilvglc niaa;Filftgvgn niaa~! smgnm mozi vmi dtbofi~v tolci bj olvgcil pti~ilvovgbl! olf oti ptbdodaw vmi eb~vgepbtvolv OPN,Eontbpmoci~ ! smgnm oti oa~b NF6( olf otivmitijbti oa~b ~y~nipvgdai vb gljinvgbl dwMGZ,D%niaa~! smgnm i}pti~~i~ -o~ D niaa tinipvbt' olf~intivi~ o ~pingjgn olvgdbfw! nol glvitloag{i vmiolvgcil smgnm dglf vb gv~ DNT olf pti~ilv gvglnbtpbtovif vb EMN GGebainyai! dyv oti glijjgngilvOPN jbt eb~v bvmit olvgcil~,
8/8/2019 antigen specificity
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L bl %ptbji~~gblo aO lbl%ptbji~~gbloa OPN fbi~ lbv nbl~vgvyvgziaw
i}pti~~ vmi Eokbt mg~vbnbepovgdgagvw nbepai}!nao~~GG-EMN nao~~GG' ptbvigl~ tiqygtif jbtglvitonvgbl sgvm logzi V niaa~,Jgdtbdao~v~-~hgl'Vmwegn ipgvmiagoa niaa~Vmwtbgf ipgvmiagoa niaa~Cagoa niaa~-dtogl'Polntiovgn divo niaa~Zo~nyaotilfbvmiagoa niaa~
8/8/2019 antigen specificity
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Nblnay~gbl
Olvgcil nblvogl~ ~pingjgn ~gvi~ jbt dglfglc vbvmi jbteglc ptbfynv~ dw
geeylbcilgngvw,vmi~i ~pingjgngvw g~ ~mbs~ vmilovyti bj vmi olvgcil,dw bd~itzglc vmi~i~pingjgngvw vmiti g~ o nmolni vb nyti vmifg~io~i dw ptbfynglc olvgdbfgi~ ~pingjgnoaaw
vb vmov olvgcil~,
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TIJITILNI^ 8
? ,Tgnmotf,O!Vmbeo~,K!Dotdoto,b! nmo%>!olvgcil~ gl Hydw geeylbabcwifl 6!S,MJTIIEOL OLF NBEPOLW40008:>%= ?
4,Nmotai~,O!Poya Vtozit~!Eoth!nmo >%olvgcil tinbclgvgbl glGEEYLB
DGBABCW ifl :!Cotaolf ~ngilni!Liswbth!40098
?07%
??=
>,Eoai!Dtb~vbjj!Tbvm!Tbgvvnmo 3!olvgcil pti~ilvovgbl glGEEYLBABCWifl 3!Eb~dw!Liswbth!400:8 ? 69%? :4
6, N Z Tob!nmo 9%olvgcil~ glGEEYLBABCW
-Lotb~o pydag~mglc Mby~i!glfgo 40098:9%3?
9, Aigfglcit,P!Hiaao,O gfilvgjgnovgbl bj aylc nolnit sgvm mgcm ~il~gvgzgvwolf ~pingjgngvw dw dabbf vi~vglc! YH!40? 0! Jid,
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