Antianginal Drugs - qu.edu.iqqu.edu.iq/ph/wp-content/uploads/2016/03/Antianginal-Drugs.pdf · Myocardial Preconditioning •Single or multiple brief periods of ischemia result in

Antianginal Drugs

Dr Laith M Abbas Al-Huseini

M.B.Ch.B, M.Sc., M.Res., Ph.D.

Myocardial Preconditioning

• Single or multiple brief periods of ischemia result in a marked reduction in infarct size when the hearts are exposed to a more prolonged period of ischemia.

• Has 2 phases:Acute and Delayed PC

• Acute phase lasts 1-2 Hours

• Delayed phase lasts 24-72 Hours

• Nitrogycerin(GTN) produces delayed PC in animal and clinical studies.

• This effect persists even in the presence of tolerance to its vasodilator effects

" Decrease in the effect of a drug when administered in a long-acting form"

NITRATES TOLERANCE

Develops with all nitrates

Is dose-dependent

Disappears in 24 h. after stopping the drug

Tolerance can be avoided

- Using the least effective dose

- Creating discontinuous plasma levels

NITRATES

CONTRAINDICATIONS

Previous hypersensitivity

Hypotension ( < 80 mmHg)

AMI with low ventricular filling pressure

1st trimester of pregnancy

WITH CAUTION:

� Constrictive pericarditis

� Intracranial hypertension

� Hypertrophic cardiomyopathy

ß-ADRENERGIC BLOCKERS CONTRAINDICATIONS

Hypotension: BP < 100 mmHg

Bradycardia: HR < 50 bpm

Chronic bronchitis, ASTHMA

Severe chronic renal insufficiency

Reasons for Using Nitrates and Beta Blockers

in Combination in Angina

• Beta Blockers prevent reflex tachycardia and contractility produced by nitrate-induced hypotension.

• Nitrates prevent any coronary vasospasm produced by Beta Blockers.

• Nitrates prevent increases in left ventricular filling pressure or preload resulting from the negative inotropic effects produced by Beta Blockers.

• Nitrates and Beta Blockers both reduce myocardial oxygen consumption by different mechanisms.

• Nitrates and Beta Blockers both increase subendocardial blood flow by different mechanisms