Anti-asthmatic drugs ยารักษาโรคหอบหืด...Lp(a) levels siqnificantly. Clinical uses Used in hypercholesterolemia, hypertriglyceridemia, combined hyperlipidemia,

Drugs used in dyslipidemia

ยารักษาภาวะไขมันในเลือดผิดปกติ

1

• Sarayut Lahnwong, M.D., Ph.D.

• Department of Pharmacology, Faculty of Medicine

• Khon Kaen University

Objectives

• Site of actions

• Mechanism of actions

• Clinical uses

• Important side effects

2

References

• Goodman and Gilmans The Pharmacological Basis of Therapeutics 13e (2018)

• Katzung & Trevor's Pharmacology: Examination & Board Review, 12e (2019)

• เภสชัวทิยา ส าหรับนักศกึษาวทิยาศาสตรส์ขุภาพ เลม่ 1, ภาควชิาเภสชัวทิยา คณะแพทยศาสตร ์มหาวทิยาลยัขอนแกน่ (2562)

3

4

Plasma lipoproteins

• Chylomicrons

• Very low-density lipoproteins (VLDL)

• Intermediate density lipoproteins (IDL)

• Low-density lipoproteins (LDL)

• High-density lipoproteins (HDL)

• Lp(a) lipoprotein

5

Plasma lipoproteins

6

Plasma lipoproteins

7

Management

8

Drugs used in dyslipidemia

• HMG-CoA reductase inhibitors: Statins

• Fibric acid derivatives: Fibrates

• Nicotinic acid: Niacin

• Bile acid binding resins

• Inhibitors of intestinal sterol absorption

• Omega-3 fatty acids (fish oil derivatives)

1. HMG-CoA reductase inhibitors

10

11

Mechanism of action

12

13

2. Fibric acid derivatives

15

16

17

3. Nicotinic acid: Niacin

19

20

4. Bile acid binding resins

22

23

24

5. Inhibitors of intestinal sterol absorption

26

27

6. Omega-3 fatty acids (fish oil derivatives)

29

Q & A