Top Banner
Antacids Acid Base Chemistry
20

Antacids

Jan 21, 2016

Download

Documents

Antacids. Acid Base Chemistry. http://redpoll.pharmacy.ualberta.ca/drugbank/  Description: The DrugBank database is a unique bioinformatics and cheminformatics. http://www.rxlist.com/script/main/hp.asp . Antacids. 12.2 Antacids. - PowerPoint PPT Presentation
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 2: Antacids

• http://redpoll.pharmacy.ualberta.ca/drugbank/ 

Description:The DrugBank database is a unique bioinformatics and cheminformatics

Page 3: Antacids

• http://www.rxlist.com/script/main/hp.asp 

Page 4: Antacids
Page 5: Antacids
Page 6: Antacids
Page 7: Antacids
Page 8: Antacids
Page 10: Antacids

12.2 Antacids• State and Explain how excess acidity

in the stomach can be reduced by the use of different bases.

• Antacids: bases, metal oxides, hydroxides, carbonates, hydrogen carbonates

• Reacts with stomach acid (excess) to adjust the stomach pH to the desired level

Page 11: Antacids

Purpose of HCl in the stomach

• To suppress growth of harmful bacteria

• To help in digestion by hydrolyzing proteins to amino acids

• Normal pH of stomach acid ~

• 1.2 – 0.3 range,

• Stress also produces more acid

Page 12: Antacids

Role of antacids

• Neutralizes the excess acids and relives the discomfort

–Excess acid can cause ulcers

Page 13: Antacids

Examples: Over the Counter

• Al(OH)3 Mg(OH)2 CaCO3

• NaHCO3

Page 14: Antacids

Alginates

• Antacids are combined with

Alginates• extracted from brown sea weeds

• produces neutralizing layer that prevents acid reflux / acid entering into oesophagus

Page 15: Antacids

Dimethicone / Antifoaming agent

• Are added to antacids to reduce the surface tension of gas bubbles

• And produce de-foaming action

Page 16: Antacids

Silicon Chemistry

• The possibilities offered to the formulation chemist by silicone chemistry are endless and yours to explore.

Page 17: Antacids

Active ingredients of some commercial antacids

• Tums: CaCO3 MgCO3 Mg Si3O8

–For the treatment of gastritis and of ulcers• Rolaids : AlNa(OH)2CO3

• Malox : Al(OH)3 Mg(OH)2

• Alka Seltzer : NaHCO3 , citric acid, aspirin

Page 18: Antacids

Alka Seltzer : NaHCO3 , citric acid, aspirin

Page 19: Antacids

Active ingredients of some commercial antacids

• Milk of Magnesia : Mg(OH)2 or MgO/Mg(OH)2 mixture

• Amphogel Al(OH)3

• Di-Gel : CaCO3

Page 20: Antacids

Action of Antacids

• Mg2Si3O8 + 4 HCl 3 SiO2(s)• 2 H2O (l) + 2 MgCl2(aq)

• Write the reactions for rest of the antacids

• Alkalosis: high doses of antacids• basic stomach• Other problems: body produces

more acids