Annual report 2009 - José Carreras Leukaemia Foundation

ANNUAL REPORT 2009

ContentsContents1. Letter from the President……………………………………P.1

2. Josep Carreras and the fight against leukaemia……P.2

3. More than 20 years fighting againts leukaemia…….P.3

1. Scientific research

2. Health infrastructures

3. Bone Marrow register

4. Services for patients and their families

5. Josep Carreras Institute for Leukaemia Research

4. Our members’ support………………………………………P.11

5. Raising awareness 2009………………………..……..……P.12

6. Press and Communication………………………………....P.13

7. Internet and social networking..…………………………P.13

8. New corporate identity……………………………………...P.14

9. The President’s activities..………………………………….P.15

10. Awareness-Raising activities…………………….........P.17

11. Support from companies..…………………………………P.19

1. Letter of the President

This year we also renewed our agreement with theSpanish Ministry of Health. The renewal reaffirms acommon desire to develop the Spanish Bone MarrowDonor Register (REDMO), managed by ourFoundationFoundation.

At present, The José Carreras Foundation, usesREDMO to work with the 30 Spanish hospitals thatprovide bone marrow transplants.

The Foundation has access to more than 14 millionbone marrow donors and more than 400,000umbilical cord blood units throughout the world, ofwhich over 80,000 and 40,000, respectively, areSpanish donors.

After more than 20 years fighting against leukaemia,we set out a new challenge: to improve the patient’squality of life and find a definitive cure for thisdisease.

To this end, the Foundation has decided to initiate anew project with the Catalan Public Administration:

Throughout these pages you will find out more aboutthe projects in which we participate to help makepatients’ plans a reality. We really want patients to beable to achieve their dreams with society’s supportand this is why we have created a number of digitalplatforms for them to share their plans.

p jthe first research centre exclusively focused onleukaemia and other hematologic diseases. It will bethe first centre of its kind in Spain and one of fewthroughout the world.

The José Carreras International Research Institutewill be unprecedented. With the work andprofessionalism of an international team ofresearchers, the Institute will use the most innovativetechnologies to win the battle against leukaemia. No se puede mostrar la imagen. Puede que su equipo no tenga suficiente memoria para abrir la imagen o que ésta esté dañada. Reinicie el equipo y, a continuación, abra el archivo de nuevo. Si sigue apareciendo la x roja, puede que tenga que borrar la imagen e insertarla de nuevo.g g

Yet as we work to achieve this objective, it is alsonecessary to improve patient care and to try toimprove their quality of life.

In response to this challenge, this year theFoundation presented two new programmes inSpain: the Residential Transplant ApartmentsProgramme and the Umbilical Cord Blood Office.

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Josep Carreras

2. Josep Carreras and the fight against

He has also been awarded the title Doctor HonorisCausa by the University of Barcelona (Spain), theUniversities of Loughborough and Sheffield (UnitedKingdom), the University Mendeleyev of Moscow(Russia), the University of Camerino (Italy), theNapier University in Edinburgh (Scotland), theRutgers University (United States), the Miguelfight against

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Hernández University of Elche (Spain), theUniversity of Coimbra (Portugal), the NationalUniversity of Music in Bucharest (Romania) , theUniversity of Marburg (Germany) the University ofPécs (Hungary), the University of Porto (Portugal)and, most recently, Honorary Rector by theHyunghee University in Korea and the Gold Medal ofthe Liceu (Barcelona).

“I always believe: if there is one chance in a million, it’s mine”.

José Carreras occupies a privileged position in themusic world. Since 1988, in addition to his

He is Honorary Member of the European Society forMedicine, of the Leukaemia Support Group, theEuropean Haematology Association and the GermanSociet of Paediat ic Oncolog and Haematolog He9 ,

professional activities, he presides with totaldedication and enthusiasm over the “JoséCarreras International LeukaemiaFoundation” established in Barcelona andwith branches in the United States,Switzerland and Germany. Currently hisLeukaemia Foundation is one of his mostimportant goals and priorities.

H i C d d l’O d d A t t d L tt

Society of Paediatric Oncology and Haematology. Heis also Honorary Patron of the European Society forMedical Oncology. He has been awarded the GoldenMedal of the Catalan Transplant Society, theDiamond Tulip Award of the Stichting Day by DayFoundation of the Netherlands and the St. BonifaceGeneral Hospital Research Foundation 1996International Award.

He is Commandeur de l’Ordre des Arts et des Lettresand Chevalier dans l'Ordre de la Légion d’Honneur dela République Française; Gran Croce di Cavaliere andGrande Ufficiale della Repubblica Italiana; HonourMedal of the Bavarian Government, Grand HonourAward of the Austrian Republic, Komandor’s Cross ofthe Order of Merit of the Polish Republic,Commandeur de la Médaille du Sahametrei of theRoyal Cambodian Government and GoodwillAmbassador of UNESCO. IN 2004 he received the4Civil Order Golden Cross of the Social Solidaritybestowed by Her Majesty the Queen of Spain, doñaSofía; the National Order Steaua Romaniei (Etoile dela Roumanie) of Romania in a degree of Grand Officerand the Big Cross of the Order of Merit of the FederalRepublic of Germany.

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3. More than 20 years fighting against leukaemia

The Foundation also funds a clinical researchprofessorship through its presence in the UnitedStates. The José Carreras and E. Donnall Thomasprofessorship is based in the Fred Hutchinson CancerResearch Centre in Seattle and has a value ofUS$1,000,000. Prof. Thomas was the world’s firstscientist to perform a bone marrow transplant aagainst leukaemia

The various José Carreras Foundations all share acommon goal: that leukaemia one day becomes acompletely curable disease – always and for everyone.They concentrate their efforts in a number of mainareas:

1. Scientific research

scientist to perform a bone marrow transplant, atreatment which now saves the lives of thousands ofleukaemia patients every year. His honourable effortsearned him the Nobel Prize for Physiology andMedicine in 1990.

The international grant for 2009 was awarded to DrFrançois Rual member of the Harvard Medical

Research grants

François Rual, member of the Harvard MedicalSchool (United States). The winning project isentitled: “Molecular and Genetic definition of theNotch signalling network, a major factor in T-ALL”.

The winner of the EHA (European HaematologyAssociation) grant for 2009 is Dr Stephan Fröling,member of the University Hospital of Ulm(Germany). His project is entitled: “IdentifyingTherapeutic Targets in CDX2-Positive Acute MyeloidLeukemia by Transcriptional Profiling and

Support for scientific research is one of the JoséCarreras Foundations’ highest priorities. Since 1988,more than €7.5 million has been invested in research

Leukemia by Transcriptional Profiling andFunctional Genomic Approaches”.

2. Health infrastructures

Another of the José Carreras Foundations’ main goalsis to bring technological advances in healthcare closerto patients. The foundations provide hospitals,laboratories and healthcare centres with new7 5

and more than 150 research projects have beenfunded. The Foundation awards national andinternational grants for the search for a cure forleukaemia. These grants cover various fields whichinclude research into the causes of leukaemia and intoimproving treatment.

The Foundation’s Scientific Committee, chaired byProf. Ciril Rozman, maintains that the best way to finda definitive cure for leukaemia is by promoting

technology and infrastructure.

For this reason and within their capabilities, thefoundations provide support to accredited and publiclyaccessible centres to allow patients and service teamsto benefit from the best possible conditions.

The Carreras Foundations have made largecontributions to the creation and development oftransplant units in cities such as Barcelona Munichy p g

research and supporting the work of young scientists.For this reason, the Foundation awards annual grantsto young researchers at both national andinternational level.

The José Carreras Foundation in Germany provided€600,000 of financing for a collaborative projectbetween the Programme for the Study of MalignantHemopathies (PETHEMA) and German MulticenterTrials (GMALL). This project, directed by Dr José

transplant units in cities such as Barcelona, Munich,and Warsaw. They have also financed the creation oftwo of the world’s major umbilical cord blood banks,established in Barcelona and Düsseldorf, each with40,000 umbilical cord blood units stored and availablefor transplant.

( ) p j , yMaríá Ribera, Head of the Haematology Service at theCatalan Oncology Institute at the Clinical University inFrankfurt, is focused on improving treatments foracute lymphoblastic leukaemia, the most commonform of the disease amongst children. This jointproject is undertaken in more than 40 hospitals inSpain and more than 100 in Germany.

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Occasionally, and with the aim of supporting charityevents and concerts to raise awareness aboutleukaemia, the Foundation and its president lendsupport to countries whose health systems still suffergreat shortages. Health and Community Centres whichhave received such support include: the CroatianL h d L k i F d ti th

ONE PATIENT, LOTS OF DONORS

The Foundation has signed agreements to work withall of Spain’s autonomous communities in order toguarantee the coordination and promotion ofdonations and that the search process for non-familydonors functions correctly allowing patients to find aLymphoma and Leukaemia Foundation, the

Department of Oncology at the Zagreb Childrens’Hospital, the University Medical Centre in Ljubljana,and the Paediatric Department at the University ofMedicine in Budapest.

donors functions correctly, allowing patients to find asuitable donor.

REDMO works with more than 100 hospitals in Spain,including third-level centres accredited for performingtransplants of hematopoietic stem cells from bonemarrow, peripheral blood and umbilical cord bloodfrom non-family donors. At present, these are thethree sources from which the cells transplanted to thepatient are obtained. Likewise, REDMO receivessearch requests for foreign patients through the sameinternational registers.

3. Bone-Marrow register

BIG CHALLENGE, FIRST STEP

The Bone Marrow Donor Register (REDMO) is theJosé Carreras Foundation’s programme to promotedonations and coordinate the search for bone marrow

The Foundation’s Official Register of BoneMarrow Donors currently holds over 80,000categorized bone marrow donors and morethan 40,000 units of stored umbilical cordblood. REDMO is connected to theinternational network and has access to 14

and umbilical cord blood donors for the treatment ofpatients without a compatible family member.

The REDMO programme began in 1991 and it is theonly body in Spain dedicated to the search for bonemarrow donors, operating under an agreementbetween the José Carreras Foundation and theMinistry of Health signed in 1994.

million voluntary donors and more than400,000 units of umbilical cord bloodavailable throughout the world for eachsearch. There are 63 bone marrow registers in44 different countries throughout the world.

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Donantes

MORE RESOURCES, NEW EXPECTATIONS

Through REDMO, the José Carreras Foundationmakes available a service for Spanish transplantcentres aimed at facilitating the search for units ofsuitable umbilical cord blood for patients in need of at l t h d t h tibl d i Growth of the number of bone marrow donors Donantes

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transplant who do not have a compatible donor intheir family.

The new system, which is included in the Ministry ofHealth and Social Policy’s National Strategy forUmbilical Cord Blood, is called the Umbilical CordBlood Centre. It will improve the selection process ofhematopoietic stem cell units and REDMO willbecome one of the first registers in the worldto put this pioneering initiative into action.

Growth of the number of bone marrow donors in Spain since 1992

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Umbilical cord blood transplants are becoming moreand more frequent in adults and children sufferingfrom leukaemia. Around 70% of searches forcompatible donors carried out by REDMO include theability to search for units of umbilical cord blood aswell as bone marrow. Until recently, the José CarrerasFoundation offered hospitals a list with thecharacteristics of the required cords and it was the

ibilit f th h it l t t t d tGrowth of the number of hematopoietic stem

cell searches initiated for Spanish patients since q

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responsibility of the hospital to carry out a study toselect the best available unit. This new initiativeimproves the efficiency of hospital centres.

cell searches initiated for Spanish patients since 1991

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Throughout 2009, REDMO carried out 687searches for hematopoietic stem cells frombone marrow, peripheral blood or umbilicalcord blood from non-family donors forSpanish patients, 117 more than in 2008.

Cryopreservation tanks for units of umbilical cord blood

Growth of the number of hematopoietic stem cell transplants from non-family donors carried

out on Spanish patients since 1993

Peripheral Bood

Umbilical Cord Blood

p p , 7

In addition 354 transplants from non-familydonors (76 bone marrow, 147 peripheral bloodand 131 umbilical cord blood) were also carriedout.

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Bone Marrow

In 2009, 682 compatible donations were found for atotal of 450 patients. The hospitals requesting them,which were part of the public health system, carriedout 354 transplants in 2009. The average time taken tofind a compatible bone marrow donor in 2009 was 50days.

Countries of origin for umbilical cord blood This year we reached a total of 41,771 umbilical cordblood units stored in Spain and available to anySpanish or foreign patient requiring them. With morethan 40,000 units, Spain has the third largest numberof units of stored umbilical cord blood in the world,after the USA and Taiwan.

During 2009, 126 of the 223 bone marrow andperipheral blood transplants carried out on Spanishpatients came from German donors 50 from American

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40

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f g fdonations made to Spanish patients in

2009

España EUA Francia Australia

Alemania Bélgica Italia Gran Bretaña

Holanda Rep. Checa Suiza

patients came from German donors, 50 from Americandonors, 17 from Spanish donors and 7 from Frenchdonors.

Hematopoietic stem cells for Spanish patients alsocame from England, Italy, Australia, Denmark,Portugal, Canada, Cyprus, Holland, Israel, Lithuania,the Czech Republic and Sweden.

SpainGermanyHolland

USABelgiumCzech R.

FranceItalySwitzerland

AustraliaEngland

12650

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Countries of origin for bone marrow and peripheral blood donations made to Spanish

patients in 2009.

Alemania EUA España FranciaGran Bretaña Italia Australia DinamarcaPortugal Canadá Chipre Holanda

Umbilical Cord Blood extraction

GermanyEnlandPortugal

USAItalyCanada

SpainAustraliaCyprus

FranceDenmarkHolland

In addition, 55 of the 131 umbilical cord bloodtransplants carried out on Spanish patients came fromSpanish donors, 40 from American donors, and 13from French donors.

Hematopoietic stem cells for Spanish patients alsocame from Australia, Germany, Belgium, Italy,

Israel Lituania Rep. Checa SueciaIsrael Lithuaniayp

Czech R. Sweden

came from Australia, Germany, Belgium, Italy,England, Holland, the Czech Republic andSwitzerland.

The Foundation works with 7 Spanish umbilical cordblood banks which extract cords in Spain’s 165accredited maternity units. There are 43 umbilicalcord blood banks in 22 different countries throughoutthe world.

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Rosario, a pacient who surrender a cord blood transplant

4. Services for the patients and their families

LONG STAY APARTMENTS

The Foundation’s apartment programme makes

In 2009, the Foundation’s apartments hosted 23patients accompanied by members of their familieswho had come from various different autonomouscommunities in Spain. Since 1994, more than 120families have benefited from this service withThe Foundation s apartment programme makes

available, at the request of hospital social workers, a“home” for patients who have to travel a long distancefrom their normal place of residence to receivetreatment and who have limited financial resources.

The Foundation has 6 such apartments, located closeto Barcelona’s main public hospitals. When patientsare receiving treatment, the Foundation’s receptionapartments mean they can have their family close at

families have benefited from this service, withpatients coming from all over Spain, as well as fromRomania, Morocco, Andorra, Mexico, Argentina,Paraguay, Peru and Russia.

hand. Once they have left the hospital, patients canthen recover with their family in a relaxed atmosphere.A Foundation representative visits them from time totime. For many, this is the only contact they have withthe city.

Places of residence of patients using the apartments

SPAIN

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THE RESIDENTIAL TRANSPLANTS APARTMENTS PROGRAMME

Many leukaemia patients who need to undergo atransplant live in the same city in which they receivetreatment, or in areas nearby. However, there are casesin which their place of residence is too far away to be

5. Josep Carreras Institute for Leukaemia Research

The José Carreras International Institute forLeukaemia Research was born from a desire todeepen the study of the mechanisms by whichp y

able to access the hospital quickly in the case of anemergency, or for out-patient treatment, etc. If thesepatients were to remain in hospital, it would normallymean two things: the occupation of a hospital bedwhich could be taken up by another patient, and beingunable to enjoy the comfort of being in a private andmore comfortable environment.

The José Carreras Foundation participates in theResidential Transplant Programme ith the Hospital

deepen the study of the mechanisms by whichleukaemia and other blood related cancers develop,with the ultimate goal of developing diagnosticprocedures and treatment and improving theirprecision. These mechanisms must be directed moreand more concretely towards resolving or avoidingdamage created by the growth and proliferation ofmalignant cells through the identification of newtherapeutic courses and the application of newtreatments.

Residential Transplant Programme with the HospitalClínic in Barcelona and has an apartment available inclose proximity to the medical centre. The HospitalClínic project is the only one of its kind in Spain andhas been in operation since 2003. As part of thissystem, patients who live in the city are able to returnto their house the day following a transplant and willreceive check-ups by a nurse once or twice a day. Atpresent, patients who live more than one hour by carfrom the Hospital Clínic at peak time are excludedp pfrom this service. However, patients who are unable tomake use of this type of transplant because they livefar away from the hospital can make use of theResidential Transplants Programme thanks to theapartment provided by the Foundation.

Three great forces were involved in the birth of theproject:

1. The will of José Carreras, his family and theFoundation to continue their fight that beganmore than 20 years ago with the goal oferadicating leukaemia.

2. The excellent level of science already foundin Catalonia, specifically in the field ofhaematology

José María, the first patient to stay in the residentialtransplant apartment

ASK A DOCTOR

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haematology.

3. The goal of the Generalitat de Catalunya toconsolidate their network of research centresand form a pioneering biotechnology andbiomedicine research facility.

This project will be the first Spanish researchcentre to focus exclusively on leukaemia andother blood related diseases, and one of the

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The José Carreras Foundation also makes available afree information service about the illness to familiesand patients affected by leukaemia throughout theworld.

only such centres in the world.

4. TO KNOW TO WHAT EXTENT WE HAVE WIPED OUT THE DISEASE

OUR CHALLENGE

In order to be able to make more concrete decisionsregarding the treatment of patients, we must continueto work towards a better understanding of themolecular characteristics of each disease. In this way itis possible to identify the minimal residual diseasebeneath the treatment undergone and to know to whatextent we have completely wiped out the disease.

5. TO FIND A MEDICAL TREATMENT FOR EVERY PATIENT

The concept of malignant blood diseases covers adiverse group of illnesses. Broadly speaking, theyinclude leukaemias, lymphomas, myelomas, andmyeloproliferative and myelodysplastic syndromes.While each illness requires its own concrete objectives,it is possible to set out seven general objectives which

We already know that each patient reacts to a givenmedicine in a different manner and that theymetabolize it in a different way. By studying how apatient metabolizes a drug on an individual basis, wecan become more effective and use less toxicmedicines. For this reason, we have a goal in the fieldof pharmacology.

EVERY PATIENT

p g jwe aimed for with the creation of the José CarrerasInstitute for Leukaemia Research

1. TO FIND A CURE NOT PROLONG THE ILLNESS

In some cases new treatments have been identifiedthat are extremely effective in prolonging patients’lives but they do not cure them Out challenge is to getlives, but they do not cure them. Out challenge is to getto the heart of the problem: the affected cells. Byunderstanding the disorder at a molecular level, wewill be able to develop new treatments to cure thepatient. One such opportunity is provided by thetransplant of hematopoietic stem cells (bone marrowand umbilical cord blood). This is a treatment whichcan cure the patient.

2. TO CATEGORIZE ILLNESSES INTO THEIR

6. TO BETTER UNDERSTAND COMMON COMPLICATIONS

2. TO CATEGORIZE ILLNESSES INTO THEIR DIFFERENT SUBTYPES

In order to make progress in developing specializedtreatments for each illness, we must first know what tocall them. Only by doing this will we be able todiscover individual treatments: therapeutic targets.

3. TO REDUCE THE SIDE-EFFECTS OF SOME TREATMENTS

The problem lies not only in better understanding thedevelopment of each illness but also in developingcontrol over the most common complications sincemany patients are lost as a result of a complication,often an infection, and not because of their ownillness. The key examples with respect to this objectiveare thromboses and haemorrhages, all too common inhaematology patients.

The rates of cure for many types of malignant blooddiseases are improving every day, but the patients stillpay a very high price. Many of the treatments areextremely toxic and have a large number of side-effects(e.g. chemotherapy, radiotherapy). We must ensurethat they are cured with the minimum possible side-effects.

TREATMENTS

7. TO GET THERE IN TIME

An important research area is in studies to predict theappearance of malignant blood diseases based on thegenetic characteristics of the population. It is alwaysbetter to be in front of the disease than behind it.

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The José Carreras International Research Institute forLeukaemia is spread across two campuses which sharea coordinated task: Campus Clínic located in the

THE PROJECTFor its part, the Generalitat de Cataluña is committedto annual funding sufficient to guarantee the runningof the José Carreras International Research Instituteagainst Leukaemia.

a coordinated task: Campus Clínic, located in thebuildings of the Hospital Clínic in Barcelona; theFaculty of Medicine of the UB, the August Pi i SunerInstitute of Biomedical Research (IDIBAPS), and theEsther Koplowitz Biomedical Research Centre(CIBEK); and also the Campus Germans Trias i Pujol,located in the area surrounding the HospitalUniversitario Germans Trias i Pujol in Badalona, theFaculty of Medicine at the Autonomous University ofBarcelona, the Germans Trias i Pujol Institute forResearch into Health Sciences (FIICSGTIP) and theIMPPCC.

The Clínic Campus has the Haematology Servicesresearch laboratories of the Haemopathology Unit atCIBEK and the Faculty of Medicine.

d h i i j l

Photograph of the Hospital Clínic in Barcelona

In order to create the Germans Trias i Pujol Campus,the City Council of Badalona has provided landadjacent to the Hospital, upon which the José CarrerasFoundation will construct a new building with around4,000m² of floor space and the Foundation willprovide equipment required by both researchcampuses. This support has been valued at€9,000,000.

The initial support for the project on behalf of the Civil

Upon achieving the complete deployment ofthe 8 to 10 envisaged research teams, theInstitute will have 100 staff, includingresearchers and auxiliaries.

In addition to its own Campuses, the Institute willThe initial support for the project on behalf of the CivilSociety of Badalona has come from the BadalonaRotary Club and the Badalona Foundation againstCancer.

p ,establish partnership agreements with other researchcentres, both national and international.

The scientific leadership of the José CarrerasInternational Institute for LeukaemiaResearch will be of global significance and willaim to attract the most distinguishedresearchers in the field of haematology.

Photograph of the Hospital Germans Trias i Pujol deBadalona (Barcelona).

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4. Our members’ support

Scientific

Resource distribution

SOCIOS

At the close of 2008 we had 19,639 membersand during the course of 2009, 11,528 peoplepledged to join forces with us and contributeregularly to the fight against leukaemia. Forthe José Carreras Foundation, this means much morethan a disinterested monthly, quarterly or annualdonation. Our members are our base in society andthey are the ones that allow us to develop ouractivities over the long term; they are the ones whokeep the fight against leukaemia going Many thanks

ResearchBone MarrowRegister

Promotion

Administration

29%6%

4%11% COMUNIDAD DE MADRID

CATALUÑAANDALUCÍA

keep the fight against leukaemia going. Many thanksto all of them.

27%14%

9%COMUNIDAD VALENCIANAGALICIAISLAS CANARIASOTRAS

Breakdown of José Carreras Foundation against Leukaemia members by autonomous community of residence

Nº SOCIS

19.63920.000

25.000

Growth in the number of members of the José Carreras Foundation between

1996 and 2009

4 635

8.11110.000

15.000

Nº SOCIS

77 90 228 253 298 326 744 852 953 1.5632.290

4.635

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The 2009 campaign sponsors were:

5. Raising awareness 2009

The Foundation campaigns are a perfect occasion toharness people’s feelings towards the fight againstleukaemia. They also present a suitable opportunityto inform society about out support. We seek topromote active participation and to develop a socialcharity movement.

In 2009, The Gregorio Marañón Hospital in Madridreceived a very special visit. José Carreras andtelevision stars such as Paula Echevarría Michelle

We are extremely pleased and grateful for theircontributions.

We would also like to extend our thanks toTransports Metropolitans de Barcelona, EmpresaMunicipal de Transportes de Madrid, Ferrocarrils dela Generalitat de Catalunya, Carat, SCPF and theMadrid Health Council who all helped to promote the

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television stars such as Paula Echevarría, MichelleJenner, Carles Francino and Iván Sánchez, spent themorning with children suffering from leukaemia andother forms of cancer in order to show their supportfor the young patients and their families, and justhow much they care.

campaign.

A disease such as leukaemia affects people of all agesand from very different backgrounds. For all of them,the immediate goal is to recover, but they all have aplan for the future that gives them the strength tofight against the illness. No matter how big or smallthose plans may be, the José Carreras Foundationwants to know about them! We asked everyone whowants to know about them! We asked everyone whowas fighting against leukaemia at the time to sharetheir plans for the future with us and let society knowabout them.

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This year, the José Carreras Foundation made an

6. Press and Communication

7. Internet and social networking

y ,effort to develop new communication channels usingthe Internet.

We have established a Facebook group, with morethan 5,000 members, a corporate blog with over 100articles and a blog named “Tell us your plan” whichhas published the aspirations of more than 50current and former patients.

We also have a news feed on Twitter and a videochannel in Youtube

The Foundation has a press office, which keeps themedia informed about its activities and those of itspresident. It also works to raise public awarenessabout leukaemia and the need to get involved andhelp in the efforts to find a cure. In 2009, theFoundation:

ad ertised in 128 ne spapers and maga ines channel in Youtube.- advertised in 128 newspapers and magazines- had adverts on 135 radio stations- issued 14 press releases.

www.cuentanostuplancontralaleucemia.blogspot.com

www fundacionjosepcarreras blogspot comwww.fundacionjosepcarreras.blogspot.com

The Foundation sends out a bulletin three times ayear to its members and financial supporters with thelatest information about the fight against leukaemia.You can see the latest bulletins in the “Publications”section of the Foundation’s website:www.fcarreras.org.

The Foundation’s website also contains informationabout the disease the donation of hematopoieticabout the disease, the donation of hematopoieticstem cells, and ways of helping, forums, etc. In 2009,the site received over 125,000 visits.

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8. New corporate identityAfter more than 20 years of history, we believe thefight against leukaemia has improved in many areas.Throughout the course of this fight, the Foundationhas also improved: we are a continually growingforce, the Bone Marrow Donor Register hasexpanded considerably, we have reached out to theworld with our annual campaigns for raisingawareness... but, among other things, there remainedone important element that needed to be changed:our corporate imageour corporate image.

It seemed to us that to modernize completely wouldrequire us to present a new image to society, one thatwas more modern and close while at the same timemaintaining the values of seriousness, rigour andtransparency.

It gives us great pleasure to share with you some ofthe elements which make up this new image and wehope you like them.

A new colour and the desire to save onprinting

The Foundation’s new corporate identity alsopresents a new corporate colour. We wanted to moveaway from the old turquoise colour which was toostrongly linked to the medical and hospitalenvironment and gave little feeling “of hope”. What’smore the new colour is printed using just one ink

Old color New color Other new colors

The new logo is easier to reproduce and is morevisible. The name of our President, José Carreras,also stands out with the goal of improving brandrecognition. As can be seen in the images, differentapplications of the logo have been previewed to takemore, the new colour is printed using just one ink

which allows us to save on costs and guarantee thesame tonality across our printed materials.

ABC abc1234567

applications of the logo have been previewed to takeinto account different mediums and print qualities.

This new corporate identity has been designed by thegraphic design studio Aire.

(http://www.airecsg.com/)

Georgia is a new transitional serif typeface designedfor Microsoft by Matthew Carter in 1993. It isdesigned for clarity on a computer monitor, even atsmall sizes. The typeface’s name was inspired by atabloid headline which makes reference to the stateof Georgia in the United States.

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9. President’s activities

The universities of Hyunghee and Oporto, aswell as the Association Farmaindustriadistinguished José Carreras for his invaluablededication to the fight against leukaemia.

This year José Carreras has been named HonoraryRector at the University of Hyunghee in Korea and

i h i i f i

The search for bone marrow and umbilicalcord blood donors is in safe hands.

Trinidad Jiménez, Minister for Health and SocialPolicy, and José Carreras signed a GeneralAgreement with the goal of modernizing thehematopoietic stem cell donor search process forbone marrow and umbilical cord blood for patientswith leukaemia and other haematologic diseases

Doctor Honoris Causa at the University of Oporto inPortugal. He also received the Farmaindustriapersonal career prize in the 2009 prizes for the bestpatient service initiatives.

Carreras has also received the distinction of DoctorHonoris Causa from the University of Barcelona, theuniversities of Loughborough and Sheffield(England), the Mendeleyev University of Moscow(Russia), the University of Camerino (Italy),with leukaemia and other haematologic diseases

which require a transplant and for which acompatible donor cannot be found in their family.The José Carreras Foundation will roll out thisinitiative through Spain.

(Russia), the University of Camerino (Italy),Edinburgh Napier University (Scotland), RutgersUniversity (United States), the Miguel HernándezUniversity of Elche, the University of Coimbra(Portugal), the University of Music in Bucharest(Romania), the University of Marburg (Germany)and the University of Pécs (Hungary). Thephotographs show Carreras receiving the award fromthe University of Hyunghee and his brother AlbertCarreras, treasurer of the Foundation, collecting theF i d i iFarmaindustria prize.

Charity concert by José Carreros in theZurich Opernhaus

With the objective of raising funds for the fightagainst leukaemia, José Carreras, accompanied bythe pianist Lorenzo Bavaj, held a charity concert inthe Zurich Opernhaus in June.

The evening of music was sponsored by the Swisst h k d j ll Ch d Ch d’

Bel canto in the cinema

José Carreras hosted the Bel canto in the cinema galaat the José Carreras Auditorium in Vila-Seca(Tarragona) for the benefit of the foundation. He wasaccompanied on stage by the young tenor SergiGiménez and the soprano Pilar Jurado to the soundswatchmaker and jeweller Chopard. Chopard’s

support has been wholly destined to the JoséCarreras Foundation for the fight against leukaemia.Chopard and the Carreras Foundation havemaintained a long relationship which dates back tothe Foundation’s early days.

Giménez and the soprano Pilar Jurado, to the soundsof the Orquesta de la Academia del Liceo conductedby David Giménez.

Bel canto in the cinema was the seventh Lyrical Galain aid of the fight against leukaemia, organizedannually by the Vila-Seca Auditorium Foundationsince 2002. On this occasion, the Gala was sponsoredby the AXA Foundation. 15

é h i ld d lJosé Carreras joins the European effort in the José Carreras, the Liceu gold medal.

On the 26th of October, José Carreras was presentedwith the 2009 Gold Medal from the Gran Teatro delLiceu in Barcelona. The distinction, which has notbeen awarded since 1979, recognizes the tenor’sartistic career spanning 50 years and his ties with thetheatre in which he began his career.

h k

José Carreras joins the European effort in thefight against cancer

José Carreras participated in the meeting of theEuropean Partnership for Action against Cancerwhich took place last September in Brussels. Themeeting was attended by the President of theEuropean Commission, José Manuel Barroso, HerMajesty Princess Mathilde of Belgium and theEuropean Commissioner for Health, AndroullaVassiliou among others The European Union seeks Thanks to Germany!

Once again the German public showed their immensegenerosity in responding to the fight againstleukaemia. The 15th Charity Gala of the InternationalJosé Carreras Foundation for the Fight againstLeukaemia raised donations to the sum of €6.4million. This act of support took place on the 18th ofDecember in Leipzig and was broadcast on theGerman public television channel ARD.

Vassiliou, among others. The European Union seeksto reinforce its long term commitment to the fightagainst cancer through the European Partnership forAction against Cancer.

With regards to this important meeting, JoséCarreras commented: “Affection, hope, company,courage, dedication, hard work... all these are greatallies in the fight against the disease. But ourstrongest ally is the knowledge derived fromscientific research to achieve a thorough

The fifteen charity galas organized by the JoséCarreras Foundation in Germany have made itpossible to raise over €82.4 million towards the fightagainst leukaemia

scientific research to achieve a thoroughunderstanding of the molecular base of cancer.Cancer is not just a Spanish, Belgian, French orItalian reality, it is a global one. It is a human reality.It concerns us all as human beings. This is why I findthis project of great importance as it concernsstrategic alliances against a common cause”. The fullspeech is available on our website:www.fcarreras.org.

On the 25th of September, José Carreras opened anew centre for leukaemia research in Germany’sMarburg University, to which the German JoséCarreras Foundation has contributed €1.6 million.The new centre has 16 beds available and is equippedwith modern laboratories with the aim of bridgingthe gap between research and patient care.

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The vice-president of the Foundation, Prof.Ciril Rozman, health personality of the year

Prof. Ciril Rozman has been awarded the prize forHealth Personality of the Year by Ediciones Mayofollowing a lifetime dedicated to scientific medicineand public service. The organizers of the prize drew

tt ti t th f t th t P f R h

10. Awareness-Raising activities

attention to the fact that Prof. Rozman hascoordinated 9 editions of the treatise Farreras-Rozman: Medicina Interna throughout the last 40years, as well as mentioning his work as editor for thejournal Medicina Clínica. They also recognized hisresearch on chronic lymphocytic leukaemia a field inwhich he is considered a world expert, and that Prof.Rozman, alongside his colleagues, carried out thefirst allograft bone marrow transplant in Spain in1976.

Pigment in its pure form

The 5th portfolio of Original Print Works to supportthe fight against leukaemia is already available fromthe foundation. The renowned artist Lluís Lleócreated the work, between figurative and abstract,and notable for its use of pigment in its pure form.Ll ó’ k b f d i i t ti l

97Lleó’s work can be found in numerous internationalcollections including: the Queen Sofia NationalMuseum Centre of Art in Madrid, the Bank of Spainin Madrid, the Nagoya Museum in Japan, the SofíaImbere Museum in Caracas and the World Bank inWashington.

The foundation has a limited run of 75 lithographs inportfolios signed by José Carreras.

The fight against leukaemia is also for... taxidrivers.

Fernando Dávila is a taxi driver in Palma de Mallorcawho is focused on raising the public’s awareness ofleukaemia. As well as being a member of theFoundation, Fernando thought about how he couldspread word about our cause in a different butconvincing way. This was how he came up with theThanks to the Badalona Rotary Club

idea of using his own working environment toachieve his goal: his taxi. Our contributor hasordered a dispenser for informative fliers for hisvehicle and is hoping to persuade all the other taxidrivers in Palma de Mallorca to help him in his ownpersonal “crusade against leukaemia”. Fernando,many thanks for your help!

The Foundation received a donation of more than€56,000 from the “Nit Paul Harris” Gala organizedby the Badalona Rotary Club (Barcelona) for itsmembers. Many thanks!

3rd Rocío Mendoza Charity Golf Tournament

For the last two years the family and friends of RocíoFor the last two years, the family and friends of RocíoMendoza, a patient who was sadly lost to leukaemia,have met to organize a supportive golf tournament.The third “homage-tournament” took place this yearat the La Envía de Almería Golf Club and raised atotal of €12,000 which José Carreras foundation willuse to fund its scientific and social programs. We’dlike to offer our thanks once again for yourinvolvement. 17

A friend forever

All of us who are part of the José CarrerasFoundation, and especially our president JoséCarreras, are devastated by the death of our friendand supporter, Alfons Gómez.

Alfons has not only been a loyal supporter but a

Fundraising rumbas and flamencos

María Carmen Smith is a very special person. Herfather died from leukaemia and she decided todedicate herself to raising money for scientificresearch. Art, rumba, flamenco, fandangos, dances:these are all dear to her and her family and this iswhy she decided to help the fight against leukaemia y y pp

GOOD person, in capitals. Each year he would go outof his way to organize various charity events to helpthe fight against leukaemia and he would also visitthe José Trueta Hospital in Girona to lift the spirits ofthose who like himself were living with that painfuldisease, by cheering up those around him. From theoutset, his “fundraising meals” became well-attendedevents in which the main course was always a sourceof pleasure. Like Alfons, Fina his wife would spendl l i ht i ll f th di

why she decided to help the fight against leukaemiain the manner closest to her. From this idea, the SanAndreu de la Barca Flaminco Festival (Barcelona)was born and took place for the second time thisyear, raising a total of €2,000. This year the SantAndreu de la Barca Club hosted Los Sobraos,Samueliko y los Sentaos, Voces de Bohemia,Alejandro Conde, Antonio Granada, and the localdance group Peña Bética. All the artists participatedvoluntarily.

sleepless nights preparing paella for the 200 diners,organizing fundraising raffles, and thinking of newways to raise awareness among society. Through hishard work and hope, Alfons managed to raise over€80,000 for the fight against leukaemia in those 9years.

However, in the end, his illness got the better of him.We give our thanks to Alfons and his family for thededication they showed to us and our cause, and fort hi h

y

Thanks to the ladies football club Cádiz FS, which,thanks to the initiative of Pablo, father of leukaemiapatient Raul, has decided to offer its support to thecure of leukaemia by wearing the Foundation’s stripsbefore matches and during training sessions.

teaching us so much.

Thanks to the Associació Aula d’ExtensióUniversitària per a la Gent Gran de Sant Cugat delVallès which organized talks on leukaemia and raised€1,600. Alfons junto a Josep Carreras en el acto de

l b ió d l ñ d l F d ió

The Basque swimmer Carlos Peña has beenswimming for 20 years in support of a number ofcauses. On this occasion, he overcame a newchallenge for the fight against leukaemia: to swimacross the Channel of Castile (130km) in aid of theJosé Carreras Foundation.

celebración de los 20 años de la Fundación.

The case of Joel, a young boy from Cambrils(Tarragona) suffering from bone marrow aplasia andawaiting a bone marrow transplant, inspired thisyear’s Cambrils Blood Marathon (28th of September)to include the possibility of giving blood andbecoming a bone marrow donor.

The campaign had the support of the Health andSocial Policy Councillor from the City Council ofCambrils, Maricel Llaveria, Núria Marieges,Coordinator of the Bone Marrow Donor Register(REDMO) from the José Carreras Foundation againstLeukaemia, and Dr Enric Contreras, Director of theBlood and Tissue Bank at the Joan XXIII hospital inTarragona.

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Thanks also to the Casa Fuster hotel in Barcelona forallowing us to make use of their marvellous interiorsand for the warmth of the hospitality they showed inallowing us to hold a photo session with JoséCarreras.

11. Support from companiesMore resources for research into bone

The company AC Marca and the José CarrerasFoundation signed an agreement to advertise thefight against leukaemia on more than 900,000containers of the well-known detergent brand Norit.The campaign, called “Help us to Care” has raisedfunds for the apartments administered by the JoséC F d ti f l k i ti t ith

More resources for research into bonemarrow transplants

The José Carreras Foundation against Leukaemiaand the medical technology company BD (Becton,Dickinson and Co.) signed a partnership agreementthrough which the company will commit tocontribute to the Foundation as a sponsor company,offering support for bone marrow transplantresearch. BD made a donation of €30,000 towardsh fi h i l k i hi h dd d Carreras Foundation for leukaemia patients with

limited financial resources.the fight against leukaemia which was added to over€7.5 million already invested by the José CarrerasFoundation in encouraging scientific research withthe goal of finding a definitive cure for leukaemia.

José Luis Gómez, General Manager of BD in Spainand Portugal, signing the agreement with JoséCarreras

Thanks to the financial services company KPMG whopledged their support to the Foundation with adonation of €15,660.

We would also like to thank Lauren Cinemas whohave shown our advert for free in all of their cinemasthroughout the months of March and April helpingus to raise awareness among an ever growing numberof people.

donation of €15,660.

Thanks to the organization Caixa Girona who havedonated €30,000 to fund our apartments for patientsand their families.

The Foundation established an agreement withMaddock Sports to provide their support. Thechildren at the football school wear strips with theFoundation logo which is also displayed on thecompany’s website. Additionally, they have agreed tospread the message about leukaemia using otherresources and amongst their students.

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Thanks to the supermarket chain BonPreu who haveraised €21,000 from customer points.

Matinée Group, musical promoter and proprietor of anumber of night clubs organized a fundraising partyfor the Foundation on the 24th of December 2009,raising awareness of our cause and donating the€13,702 raised in its entirety.

Businesses take the fight against leukaemia totheir employees.

The company Mango organized a blood donationcampaign throughout its workforce in September2009. Loyal in the support they offer to the JoséCarreras Foundation against Leukaemia, they also

The José Carreras Foundation is now part of SocialBid, an initiative to help finance Spanish NGOprojects by selling supportive merchandise online. Byvisiting the Social Bid website (www.socialbid.es) youcan give your support to the fight against leukaemiain a slightly different manner, by purchasing ourfundraising prints by well-known artists such asg , y

took the opportunity to inform themselves aboutbone marrow donation, a procedure morestraightforward and of greater importance than mostpeople believe.

Additionally, the sponsor Würth included one of theFoundation’s adverts in four editions of its monthlyonline magazine read by its employees and with amonthly circulation of 50,000 copies.

g p yAntoni Saura, José Maria Riera i Aragó, RobertVanderycken, Lluís Lleó and Ramon Pujolboira.

The Foundation established an agreement withEureka Kids to give their support. Throughout

Finally, the multinational company Sara Lee alsogave its support by informing workers about bonemarrow and umbilical cord blood donation andencouraging them to give their support to the morethan 5,000 people who suffer from the disease inSpain.

Other companies such as Grupo Prosolar, Honda,Cerco Educa and Elephant Seven have also

November and December, they displayed theFoundation’s fliers in their 60 branches, donated €3from the Discovery Puzzle toy sold during thesemonths, and also showed the Foundation’s banner ontheir website and included an advert in theircatalogues.

phelped to further our cause.

Thank you all for your solidarity and support!

This year, as in many others, Mango, Engás,Laboratorios Esteve, Renta Corporación and El MolíVell have helped us by making important donations.

Executives without ties... against leukaemiag

More than 50 executives from Barclays offices inCatalonia and the Balearic Islands took off their ties toparticipate in an activity in Barcelona to raise funds forthe fight against leukaemia.

The Barclays employees took part in a circuit ofphysical trials, a relay race and a sack race. As well asraising funds for our cause, a good time was had by all.Each of those who took part made a donation of €10

d th B l F d ti d bl d th fi l

There are many companies who offer their customersways to support us: La Caixa, Banc Sabadell andRACC all have points programmes to support theFoundation. Additionally, Caja Navarra allowsprojects from the Foundation to be chosen with itscivic banking programme “You choose, you decide”.

and the Barclays Foundation doubled the final sumraised by the employees. Many thanks Barclays!

Caixa Pendès also has a supporting fund for ourFoundation.

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M2007

If you would like to receive a copy of the Foundation’s annual accounts for the 2009 financial

ContactIf you would like to receive a copy of the Foundation s annual accounts for the 2009 financialyear, or for any other information, please contact us using the details below.

José Carreras Leukaemia Foundation

C/Muntaner, 383 2º

08021 Barcelona (SPAIN)08021 Barcelona (SPAIN)

T. 0034 900 32 33 34 F. 0034 93 201 05 88

Email: [email protected]

Web: www.fcarreras.org

Thank you!!!