Annexure- Ienvironmentclearance.nic.in/writereaddata/FormB/EC/...Annexures.pdf · ANNEXURE-II: POINT WISE TABULAR COMPLIANCE OF AWARDED TOR The project authorities gave a detailed

Existing CC&A with compliance

Annexure- I

M/s. Heni Drugs Pvt. Ltd. Plot No. 1901/1901A, Phansa Char Rasta,

GIDC, Sarigam – 396155 Tal. Umbergaon, Dist. Valsad. Gujarat (INDIA).

Page 1 of 4

COMPLIANCE REPORT OF CCA

For Water (Prevention and control of pollution) ACT –1974, Air (Prevention And Control of Pollution) Act – 1981 and Authorization under Hazardous waste –Management Rules -2003:

1. Consent Order No. : AWH - 65133, dated of issue: 22/09/2014. 2. The consents shall be valid up to 11/06/2019 for use of outlet for the discharge of treated

effluent & emission due to operation of industrial plant for:

Sr. No.

product As per CCA MT/Month

1. Continuous distillation of crude ethylOleate 25

2. Metal salt of copper, cobalt, Nickel, Bismuth, Mercury and Aluminum Magnesium Mix Hydrotalcite salt

75

Sr. No.

CONDITION COMPLIANCE STATUS

CONDITION UNDER THE WATER ACT:

3.1. The quantity of the industrial effluent from the manufacturing process and other ancillary industrial operations shall be nil.

We do comply with this condition

3.2 The quantity of domestic sewage effluent from the factory shall not exceed 1.800 KL/day.


3.2.1 Sewage shall be dispose of through septic tank/ sock pit system.


4. CONDITIONS UNDER THE AIR ACT:

4.1 The following shall be used as fuel. Natural Gas : 50SCm/Hr.

4.2 The applicant shall install & operate comprehensive adequate air pollution in order to achieve prescribed norms control system so as to achieve standard.

We do comply with the condition. And the stack Monitoring report is enclosed as Annexure-1.

4.3 The flue gas emission through stack attached to Boiler / Furnace / Heater shall conform to the following standards: (Mention in consent)

We do comply with the condition. The stack Monitoring report is enclosed as Annexure-1.

4.4 There shall be no process emission from the manufacturing process and other ancillary industrial operations.

We do comply with the condition.



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4.5 Ambient air quality within the premises of the industry shall conform to the following standards:-

PARAMETERS PERMISSIBLE LIMIT

Annual 24 Hrs Average Particulate Matter-10 (PM10)

60 Microgram/M3 100 Microgram/M

3

Particulate Matter-2.5 (PM2.5)

40 Microgram/M3 60 Microgram/M

3

SO2 50 Microgram/M3 80 Microgram/M

3

NOx 40 Microgram/M3 80 Microgram/M

3

Annual arithmetic mean of minimum 104 measurements in a year at a particular site taken twice a week 24 hourly at uniform intervals.

24 hourly or 08 hourly or 01 hourly monitored values, as applicable, shall be complied with 98 % of the time in a year. 2 % of the time, they may exceed the limits but not on two consecutive days of monitoring.

We do comply with the condition.the Existing Ambient air quality monitoring report is enclosed as Annexure-1.

4.6 The applicant shall operate industrial plant/air pollution control equipment very efficiently and continuously so that the gaseous emission always conforms to the standards specified in condition no. 4.3 and 4.6 as above.


4.7 The consent to operate the industrial plant shall lapse if at any time the parameters of the gaseous emission are not within the tolerance limits specified in the condition no. 4.3, and 4.6 as above.


4.8 The applicant shall provide portholes, ladder, platform etc at chimney(s) for monitoring the air emissions and the same shall be open for inspection to/and for use of Board’s staff. The chimney(s) vents attached to various sources of emission shall be designed by numbers such as S-1, S-2, etc. and these shall be painted /displayed to facilitate identification.

We are complying with the condition.

4.9 The industry shall take adequate measures for control of noise levels from its own sources within the premises so as to maintain ambient air quality standards in respect of noise to less than 75 dB(a) during day time and 70 dB(A) during night time. Daytime is reckoned in between 6 a.m. and 10 p.m. and nighttime is reckoned between 10 p.m. and 6 p.m.

We are complying with the condition and the Ambient noise monitoring report is enclosed as Annexure-1.

5 Authorization for the [Management, Handling & Transboundary Movement of Hazardous Waste] Rules-2008, Form-2 (See rules 5 (4) for grant of Authorization for occupier under handling Hazardous Waste.




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5.1 M/s. Heni Chemical Industries is hereby granted an authorization to operate facility for following hazardous waste on the premises situated at plot No. 1901, GIDC Estate, Village:

Sarigam, Ta: Umbergaon, Dist: Valsad- Sarigam. (Mention in consent)

5.2 The authorization is granted a facility for collection, storage within the factory premises and treatment, transportation and ultimate disposal of Hazardous wastes as per Haz. Waste [Management, Handling & Transboundry Movement] Rules 2008.


5.3 The authorization is subject to the conditions stated below and such other conditions as may be specified in the rules from time to time under the Environment (Protection) Act-1986.


5.4 The authorization shall be in force for period of five years (i.e. up to 10/06/2019).

We do comply with the directives issued by the competent authorities time to time.

5.5 TERMS AND CONDITIONS OF AUTHORIZATION

5.5.1 The applicant shall comply with the provisions of the Environment (Protection) Act – 1986 and the rules made there under.


5.5.2 The authorization shall be produced for inspection at the request of an officer authorized by the Gujarat Pollution Control Board.


5.5.3 The persons authorized shall not rent, lend, sell and transfer of otherwise transport the hazardous wastes without obtaining prior permission of the Gujarat Pollution Control Board.


5.5.4 Any unauthorized change in personnel, equipment or working conditions as mentioned in the authorization order by the persons authorized shall constitute a breach of this authorization.


5.5.5 It is the duty of the authorized person to take prior permission of the Gujarat Pollution Control Board to close down the facility.


5.5.6 An application for the renewal of an authorization shall be made as laid down in rule - 5(7) (II).


5.5.7 Industry shall submit annual report within 15 days and sub squinty by 31st January every year.


6. GENERAL CONDITIONS:

6.1 Any change in personnel, equipment or working conditions as mentioned in the consents form/order should immediately be intimated to this Board.


6.2 The waste generator shall be totally responsible for We do comply with the condition.



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collection, storage, transportation and ultimate disposal of the waste generated.

6.3 In case of any accident, details of the same shall be submitted in form-5 to Gujarat Pollution control Board.


6.4 As per public Liability Insurance Act-91” company shall get insurance policy, if applicable.

We do comply with the condition

6.5 Empty drums and containers of toxic and hazardous material shall be treated as per the guidelines published for “Management & Handling of discarded containers” Record of the same shall be maintained and forwarded to Gujarat Pollution Control Board regularly.


6.6 Unit shall take all concrete measures to show tangible results in waste generation reduction avoidance, reuse and recycle. Action taken in this regard shall be submitted within 03 months and also along with form-4.


6.7 Industry shall have to display the relevant information with regard to hazardous waste as indicated in the Hon. Supreme Court’s order in W.P. No: 657 dated 14th October 2003.


For M/s. Heni Drugs Pvt. Ltd. (Authorized Signatory)

Awarded TOR & its compliance status

Annexure- III Annexure- II

M/s. Heni Drugs Pvt. Ltd., Sarigam

A

ANNEXURE-II: POINT WISE TABULAR COMPLIANCE OF AWARDED TOR

The project authorities gave a detailed presentation on the salient features of the project and

proposed environmental protection measures to be undertaken along with the draft Term of

References for the preparation of EIA/EMP report. All Synthetic Organic Chemicals Industry

located inside the notified industrial area/estate are listed at S.N. 5(f) under category ‘B’ and

appraised by State Expert Appraisal Committee.

M/s Heni Drugs Pvt. Ltd. has proposed to expand their existing manufacturing unit at Plot No.

1901/1901A, Phansa Char Rasta, GIDC, Sarigam, Tal. Umargam, Dist.-Valsad, Gujarat-396155 by

addition of new products “Esters, organic intermediates, Aromatic metal compounds, Extracts

and Oils @ 395 MT/Year” which are Synthetic Organic Chemicals. Total plot area is 6700.00

m2. Total cost of the project is Rs. 420 Lacks. Darotha River (a tributary of Damanganga river) is

flowing at a distance of 6.00 Km. D&NH wildlife sanctuary is located at a distance of 14 Km.

Following are the particulars of Awarded TOR Points & point wise compliance status with

compliance note:

TOR No.

TOR Condition Compliance Status

1 Need for the proposed expansion should be justified in detail.

Need for the proposed expansion has been described in EIA report of Chap-1, Section-1.4.1, page 1-4.

2 Explore the possibility of substitute products and processes containing or using mercury With non-mercury (Mercury free) alternatives.

The company is focusing its efforts on expanding its product portfolio beyond the mercury compounds. The company has been supplying some key mercury salts to end users for many years. With time the use and applications are reducing. The company has identified the same and thus building an alternative product portfolio like other metals salts and vegetable based esters which form the main volume of this application. Thus the company is already on the path to reduce the volume of mercury business.

3 Ensure that the various regulations for use, storage and transportation of Mercury metal/Compounds will be complied in letter and spirit. Give legal undertaking in this regard.

Legal undertaking is enclosed as Annexure-XI.

4 Demarcation of proposed expansion activities in lay out of the existing premises.

Complied Layout plan of the factory premises with showing demarcation of proposed expansion activity has been given in EIA Report under Chapter 2, fig.-2.3, Page no 2-8. and Annexure-XI(A).


B

5 Exact aerial distance from the CEPI area of Vapi and Interstate boundary from the project Premises.

The Aerial distance form CEPI - Vapi

@9.03 Km NE

Interstate boundary from the project

premises

1. Dadra & Nagar Haveli – 7.35 Km E 2. Daman – 9.25 km N

6 Exact details about additional infrastructural facilities, plant machineries etc. required for the proposed expansion.

Complied The Detail about additional infrastructural facilities, plant machineries has been given in EIA report under Chap.-2, section-2.2, Page- 2-7 to 2-19.

7 Technical details of all the plants along with details of manufacturing process/operations Of each product. Details on strategy for the implementation of cleaner production activities.

Complied Technical details of all the plants along with details of manufacturing process / operations of each product has been given in Chap.-2, Section- 2.3.2, Page- 13-19.

8 Chemical name of each product and raw materials along with chemical reactions of unit Processes. Detailed manufacturing process of each product along with chemical reactions and mass balance (including reuse-recycle, if any).

Complied

Chemical name of each product has been given in Chap.-2, Section - 2.1.1, Table- 2.2, Page- 2-3. And Raw materials along with chemical reactions of unit processes has been given EIA report under Chap.-2, Section - 2.3.1, Page- 2-12

Detailed manufacturing process of each product along with chemical reactions and mass balance has been given in EIA report under Chap.-2, Section - 2.3, Page- 2-12.

9 Assessment of source of the water supply with adequacy of the same to meet with the requirements for the project expansion. Permission obtained for supply of increased quantity of raw water. Undertaking stating that no bore well shall be dug within the premises.

Complied

Source of the water supply- GIDC Sarigam.

Adequacy of the water consumption to meet with the requirements for the project expansion has been given in EIA report under Chap.-2, section-2.2.2, Page- 2-9.

Undertaking stating that no bore well shall be dug within the premises is enclosed as Annexure-XI.

10 Water consumption and consumption of each raw material per MT of each product.

Complied Water consumption and consumption of each raw material per MT of each product have been given in EIA report under chap.-2, Section 2.2.2, page- 2-9 & Section - 2.3.2., page- 2.13.


C

11 Water balance diagram (including reuse-recycle, if any) along with qualitative and quantitative analysis of the each waste stream to be generated. A detailed treat ability study vis-à-vis the adequacy and efficacy of the treatment facilities proposed for the wastewater to be generated. The characteristic on which treatability is based shall also be stated. Characteristics of untreated and treated wastewater.

Complied

Water balance diagram has been given in EIA report under chap.-2, Section -2.4.2, fig. - 2.4, page- 2-20.

Qualitative and quantitative analysis of the each waste stream to be generated have been given in Adequacy & treatability report as Annexure- VIII of EIA report.

A detailed treat ability study vis-à-vis the adequacy and efficacy of the treatment facilities proposed for the wastewater to be generated have been given in Adequacy & treatability report as Annexure- VIII of EIA report.

Characteristics of untreated and treated wastewater have been given in Adequacy & treatability report as Annexure- VIII of EIA report.

12 Quality and quantity of waste water to be generated from the manufacturing process of each product to be manufactured along with mass balance.

Complied The Quality and quantity of waste water to be generated from the manufacturing process of each product to be manufactured along with mass balance have been given in Adequacy and treatability report as Annexure-VIII of EIA report.

13 Stream wise qualitative & quantitative analysis of each waste stream (including process water, cooling tower blow down, boiler blow down, washing effluent etc.) to be generated. Characteristics of untreated and treated wastewater. A detailed effluent treat ability study vis-à-vis the adequacy and efficacy of the treatment facilities proposed for the wastewater to be generated. The characteristic on which treatability is based shall also be stated.

Complied The detail of Stream wise qualitative & quantitative analysis of each waste stream (including process water, cooling tower blow down, boiler blow down, washing effluent etc.) generation and Characteristics of untreated and treated wastewater have been given in treatability report as Annexure- VIII of EIA report.

14 Detailed effluent treatment scheme and disposal method. Technical details of the proposed ETP, including size of each unit, retention time etc. including modifications / upgradation to be done in existing ETP to take care of increased effluent quantity along with its adequacy report.

Complied The Detailed effluent treatment scheme and disposal method. Technical details of the proposed ETP, including size of each unit, retention time etc. including modifications / up gradation to be done in existing ETP to take care of increased effluent quantity along with its adequacy report have been given in Adequacy and treatability report as Annexure-VIII of EIA report.


D

15 Technical details of specific treatment for Mercury in effluent.

The Technical details of specific treatment for Mercury in effluent are given in Adequacy and treatability report as Annexure-VIII of EIA report.

16 Details of CETP- Sarigam including (1) Total capacity of the CETP (2) Total booked capacity and actual load received at present (Qualitative and Quantitative) (3) CETP Up gradation scheme, if any (4) Last 2 years analysis reports of GPCB for Inlet and outlet of CETP (5) Spare capacity of CETP with treatability and feasibility report. (6) Recommendations and suggestions of the last two Environment Audit reports of CETP Sarigam and its compliance report.

We have made an application to CETP, Sarigam regarding (1) Total capacity of the CETP (2) Total booked capacity and actual load received at present (Qualitative and Quantitative) (3) CETP Up gradation scheme, if any (4) Last 2 years analysis reports of GPCB for Inlet and outlet of CETP (5) Spare capacity of CETP with treatability and feasibility report. (6) Recommendations and suggestions of the last two Environment Audit reports of CETP Sarigam and its compliance report.

The acknowledged copy of the application made and the CETP membership letter received has been enclosed as Annexure-XI(C).

17 Plan for management and disposal of waste streams to be generated from spillage, leakages, occasional reactor washing, and exhausted media from Scrubber etc.

The plan for management and disposal of waste streams to be generated from spillage, leakages, occasional reactor washing has been described in EIA report under chap-10, section 10.4.2., page 10-10.

18 Explore the possibility of reuse/recycle and other cleaner production options for reduction of wastes. Details of methods to be adopted for the water conservation.

Compiled. The Detail of reuse/recycle for reduction of wastes has been described in EIA report under chap-10, section 10.4.13., page 10-30.

19 Undertaking stating that a separate electric meter will be provided for the ETP.

Undertaking stating that, a separate electric meter will be provided for the ETP is enclosed as Annexure-XI.

20 One season Site-specific micro-meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall should be incorporated.

One season Site-specific micro-meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall have been given in EIA report under chap.3 of Section 3.

21 Anticipated environmental impacts due to the proposed project/production may be evaluated for significance and based on corresponding likely impacts VECs (Valued Environmental Components) may be identified. Baseline studies may be conducted within the study area of 5 km for all the concerned/identified VECs and likely impacts will have to be assessed for their magnitude in order to identify mitigation measures.

Complied The details of Anticipated environmental impacts due to the proposed project/production within the study area of 5 km and its mitigations have been explained in EIA Report under Chapter 4 of EIA report. Baseline studies has been conducted within the study area of 5 km for all the concerned/ identified VECs and details of the study has been described in chapter 3 of EIA report.


E

22 One complete season base line ambient air quality data (except monsoon) to be given along with the dates of monitoring. The parameters to be covered shall be in accordance with the revised National Ambient Air Quality Standards as well as project specific parameters. Locations of the monitoring stations should be so decided so as to take into consideration the pre-dominant downwind direction, population zone and sensitive receptors. There should be at least one monitoring station in the upwind direction. There should be at least one monitoring station in the pre dominant downwind direction at a location where maximum ground level concentration is likely to occur.

Complied The details of One season base line ambient air quality monitoring at 6 locations has been explained in EIA Report under Chapter 3, Section 3.2.4, Page no. 3- 25.

23 Modelling indicating the likely impact on ambient air quality due to proposed activities. The details of model used and input parameters used for modelling should be provided. The air quality contours may be shown on location map clearly indicating the location of sensitive receptors, if any, and the habitation. The wind rose showing pre dominant wind direction should also be indicated on the map. Impact due to vehicular movement shall also be included into the prediction using suitable model. Results of Air dispersion modelling should be superimposed on google map / geographical area map.

Complied Modeling indicating the impact on ambient air quality due to proposed activities and air quality contour map clearly indicating the location of sensitive have been described in EIA Report under Chapter 4, Section 4.3.1, Page no. 4-09.

24 Base line status of the noise environment, impact of noise on present environment due to the project and proposed measures for noise reduction including engineering controls.

Complied Baseline status of noise environment has been presented in EIA Report under Chapter 3, Section 3.2.5, Page no.3-27. and Impact of noise on present environment due to the project and proposed measures for noise reduction including engineering controls have been presented in EIA Report under Chapter 4, Section 4.3.6 Page no.4-26.


F

25 Specific details of (i) Process gas emission from each unit process with its quantification, (ii) Air pollution Control Measures proposed for process gas emission, (iii) Adequacy of the air pollution control measures for process gas emission measures to achieve the GPCB norms (iv) Details of the utilities required (v) Type and quantity of fuel to be used for each utility (vi) Flue gas emission rate emission from each utility (vii) Air Pollution Control Measures proposed to each of the utility along with its adequacy (viii) List the sources of fugitive emission along with its quantification and proposed measures to control it.

Details of process emission its control, Measures and efficiency of control measures is provided in EIA Report under Chapter 2, Section 2.4.1, Page no.2-19. Details of the utilities have been described in EIA Report under Chapter 2, Section 2.4.1, Page no.19-21. There is no considerable source of fugitive emission.

26 Name and quantity of each type of solvents to be used for proposed production. Details of solvent recovery system including mass balance, solvent loss, recovery efficiency feasibility of reusing the recovered solvents etc. for each type of solvent.

All solvents are utilized in the finished product preparation. Hence issue of solvent recovery is not anticipated.

27 Details on management of the by-products and spent acid to be generated along with copies of MOU/agreements done with actual consumers regarding utilization of byproducts & spent acids shall be incorporated.

There are no any kind of by-products and spent acid generation during manufacturing of existing and proposed product. Hence this condition is not applicable.

28 Details of management of the hazardous wastes to be generated from the project stating detail of storage area for each type of waste, its handling, its utilization and disposal etc. How the manual handling of the hazardous wastes will be minimized.

Details on management of the hazardous wastes to be generated from the project stating, storage area for each type of waste, its handling, its utilization and disposal have been described in EIA Report under Chapter 2, Section 2.4.3, Page no.2-21. and Environment management plan for handling of the hazardous wastes, minimization, Methodology of de-contamination and disposal of discarded containers and its record keeping have been described in EIA Report under Chapter 10, Section 10.4.7, Page no.10-17.

29 Methodology of de-contamination and disposal of discarded containers and its record keeping.

Complied The Methodology of de-contamination and disposal of discarded containers and its record keeping are given in EIA Report under Chapter 10, Section 10.4.7, Page no.10-17.


G

30 Membership of Common Environmental Infrastructure including the TSDF / Common Hazardous Waste Incineration facility along with an assessment to accommodate the additional quantity of wastes to be generated. Explore the possibilities for co-processing of the Hazardous waste prior to disposal into TSDF/CHWIF.

Complied Application for obtaining membership of Common Environmental Infrastructure including CETP, TSDF have been made. Annexure-XI(D)

31 Data on air emissions, wastewater generation and solid / hazardous waste generation and management for the existing plant should also be incorporated.

Complied The detail of The detail of air emissions, wastewater generation and solid / hazardous waste generation and management for the existing plant has been described in EIA repot under Chap-2, section 2.4.1 to 2.4.3, page no.-2-22 to 26.

32 Details of measures proposed for the noise pollution abatement and its monitoring.

Complied The details of measures proposed for the noise pollution abatement and its monitoring has been described in EIA repot under Chapter 10, Section 10.4.6, Page no.10-16.

33 A detailed EMP including the protection and mitigation measures for impact on human health and environment as well as detailed monitoring plan and environmental management cell proposed for implementation and monitoring of EMP. The EMP should also include the concept of waste-minimization, recycle/reuse/recover techniques, energy conservation, and natural resource conservation. Total capital cost and recurring cost/ annum earmarked for environment pollution control measures.

Complied The detailed EMP has been described in EIA Report under Chapter 10. The details of energy conservation, waste minimization &reuse/recycle, resource recovery & reuse/recycling etc. have been described as Cleaner Production Measures in EIA Report under Chapter 10, Section 10.1, Page No.10-01 Detailed monitoring plan and Total capital cost and recurring cost/Year earmarked for environment pollution control measures have been given in Chapter 10 Section 10.2, Page no 10-5.


H

34 Occupational health impacts on the workers and mitigation measures proposed to avoid the human health hazards along with the personal protective equipment to be provided to the workers. Provision of industrial hygienist and monitoring of the occupational injury to workers as well as impact on the workers. Plan for periodic medical checkup of the workers exposed. Details of work place ambient air quality monitoring plan as per Gujarat Factories Rules.

Complied Details of Occupational health impacts on the workers and mitigation measures proposed to avoid the human health hazards along with the personal protective equipment to be provided is described in EIA report, Chapter 4, Section 4.3.8, Page No. 4.38 and Chapter 8, Section 10.1, page no.10.3. Some employees working in the storage and production area are suspected to be exposed to some toxic/hazardous chemicals. Considering the probability of the exposure to the hazardous chemicals a separate document of “Safety measures for Hazardous Chemicals” is prepared as a part of RA report which has been Described in Annexure-VI of EIA report.

35 Details of hazardous characteristics and toxicity of raw materials and products to be handled and the control measures proposed to ensure safety and avoid the human health impact.

The Details of hazardous characteristics and toxicity of raw materials and products to be handled are given in EIA report under Chap. 2 of Table 2.10, page no.2-14. And The control measures proposed to ensure safety and avoid the human health impact has described in Chemical Safety plan report which has been present as Annexure-VII of RA report.

36 Details of quantity of each hazardous chemical to be stored, material of construction of major hazardous chemical storage tanks, threshold storage quantity as per schedules of Manufacture, Storage & Import of Hazardous Chemicals Rules of major hazardous chemicals.

Complied The details of quantity of each hazardous chemical to be stored, material of construction of major hazardous chemical storage tanks, threshold storage quantity as per schedules of Manufacture, Storage & Import of Hazardous Chemicals Rules of major hazardous chemicals are given in Table 7.1, of chap.7 in EIA report, page no.-7-2.


I

37 Risk assessment including prediction of the worst-case scenario and maximum credible accident scenarios should be carried out. The worst-case scenario should take into account the maximum inventory of storage at site at any point of time. The risk contours should be plotted on the map clearly showing which of the facilities and surrounding units would be affected in case of an accident taking place. Based on the same, proposed safeguard measures including On-Site/Off-Site Emergency Plan should be provided.

Complied. The Risk Assessment report which has been present EIA report, Chapter-7. And Proposed safeguard measures including On-Site/Off-Site Emergency Plan is given in DMP report which has been enclosed as Annexure- VI of EIA report.

38 Permission from PESO, Nagpur for storage of solvents, other toxic chemicals, if any.

PESO act and rules is not applicable to the materials of project, hence Permission from PESO is not required.

39 Details of fire fighting system including provision for flame detectors, temperature actuated heat detectors with alarms, automatic sprinkler system, location of fire water tanks & capacity, separate power system for fire fighting, details of qualified and trained fire personnel & their job specifications, nearest fire station & time required to reach the proposed site. Submit line diagram of the fire hydrant network.

Complied. The detail of firefighting system including provision for flame detectors, temperature actuated heat detectors with alarms, automatic sprinkler system, location of fire water tanks & capacity, separate power system for firefighting are given in Section 2(c), page no.3 of DMP report, which has been enclosed as Annexure- VI of EIA report. The details of qualified and trained fire personnel & their job specifications, nearest fire station & time required to reach the proposed site are given in Section 2(c), page no. 4 to 6 of DMP report, which has been enclosed as Annexure- VI of EIA report.

40 Detailed five year greenbelt development program including annual budget, types & number of trees to be planted, area under green belt development [with map], budgetary outlay; along with commitment of the management to carry out the tree plantation activities outside the premises at appropriate places in the nearby areas and elsewhere.

The details of greenbelt development have been described in EIA Report under Chapter 10, Section 10.4.11, Page no.10-23.

41 Proposal for socio-economic development activities including community welfare program most useful in the project area for the overall improvement of the environment.

Complied The details of socioeconomic development activities have been described in EIA Report under Chapter 11, Section 11.7, Page no 11-10. Details of CSR Activity year wise plan enclosed as Annexure- IX.


J

42 Copies of Consent to Establish, Consent to Operate orders obtained in past along with point wise compliance status of all the conditions stipulated therein.

Complied. The Copies of Consent to Establish, Consent to Operate of existing unit with its compliance are enclosed as Annexure-I of EIA report.

43 Copy of Environmental Clearance obtained for the existing project and a certified report of the status of compliance of the conditions stipulated in the environmental clearance for the existing operation of the project by the Regional Office of the MoEF.

The Existing product of proposed expansion project are inorganic products with only mixing and blending, As per EIA notification 2006, as amended Environmental Clearance was not obtained for existing product. Hence, this condition is not applicable

44 Records of any legal breach of Environmental laws i.e. details of show- cause notices, closure notices etc. served by the GPCB to the existing unit in last five years and actions taken then after for prevention of pollution.

Closure notice and reply regarding violation of water Act under 1974 is enclosed as Annexure-X

45 Details of fatal / non-fatal accidents, loss of life or man hours, if any, occurred in the existing unit in last three years and measures proposed to be taken for avoiding reoccurrence of such accidents in future.

There is no any kind of fatal / non-fatal accidents, loss of life or man hours occurs in existing unit last three years.

46 (a) Does the company have a well laid down Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report. (b) Does the Environment Policy prescribe for standard operating process/ procedures to bring into focus any infringement/deviation/violation of the environmental or forest norms/conditions? If so, it may be detailed in the EIA.

The company has laid down “Environmental Policy” as described in EIA Report under Chapter 10, Section 10.3.1, Page no. 10-6.

47 What is the hierarchical system or administrative order of the company to deal with the environmental issues and for ensuring compliance with the EC conditions. Details of this system may be given.

Complied The details the hierarchical system have been described in EIA Report under Chapter 10, Section 10.32, Page no. 10-7

48 Submit checklist in the form of Do’s & Don’ts of preventive maintenance, strengthening of HSE, manufacturing utility staff for safety related measures.

Complied checklist in the form of Do’s & Don’ts of preventive maintenance, strengthening of HSE, manufacturing utility staff for safety related measureshave been described in EIA Report under Chapter 7, Section 7.3.4.,Page No.7-22


K

49 Does the company have a system of reporting of non compliances/violations of environmental norms to the Board of Directors of the company and/or shareholders or stakeholders at large? This reporting mechanism should be detailed in the EIA Report.

Yes,the company will developed system of reporting of non-compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large.and This reporting mechanism has been documented in EIA Report under Chapter 10, Section 10.3.2, Page no. 10-7

50 Compliance of the MoEF’s OM dated 04/08/2009 and 05/10/2011 regarding compliance of TOR prescribed & factual correctness of the data submitted in the EIA report, the names of experts associated with / involved in the preparation of the EIA report and the ownership of the EIA report by the Project proponent.

Complied. The compliance of the MoEF’s OM dated 04/08/2009 and 05/10/2011 regarding compliance of TOR prescribed & factual correctness of the data submitted in the EIA report- regarding the under taking given by the EIA consultant and Project proponent with signed has been incorporate after cover page in EIA report .

51 Certificate of accreditation issued by the NABET, QCI to the environmental consultant should be incorporated in the EIA Report.

Complied. The copy of Certificate of accreditation issued by the NABET, QCI to the environmental consultant are incorporate in chap.12 of EIA report.

Micrometeorological Data

Annexure- III


TEMPERATURE (◦C)

Month Maximum Minimum Average November - 2015 37.10 23.00

28.51 December - 2015 30.50 24.60 January- 2016 34.00 21.10

RELATIVE HUMIDITY (%)



WIND SPEED (m/s)



URBAN MIXING HEIGHT (m)




FREQUENCY COUNT

Date 1/03/2015 31/05/2015 Time 0.00 23.00 Organization M/s. Unistar Environment and Research Labs Pvt. Ltd. Location G.I.D.C. Vapi. Calm 2.58% Total Samples 2208 Directions 0.50 - 2.10 2.10 - 3.60 3.60 - 5.70 5.70 - 8.80 8.80 - 11.10 >= 11.10 Total

NNE 138 181 203 3 0 0 525 ENE 200 233 168 1 0 0 602 ESE 186 187 101 0 0 0 474 SSE 54 94 53 2 0 0 203 SSW 20 15 12 1 0 0 48 WSW 21 16 12 0 0 0 49 WNW 32 26 16 0 0 0 74 NNW 22 49 84 0 0 0 155

FREQUENCY DISTRIBUTION

Date 1/03/2015 31/05/2015 Time 0.00 23.00 Organization M/s. Unistar Environment and Research Labs Pvt. Ltd.

Location G.I.D.C. Vapi. Calm 2.58% Total Samples 2208

Directions 0.50 - 2.10 2.10 - 3.60 3.60 - 5.70 5.70 - 8.80 8.80 - 11.10 >= 11.10 Total NNE 0.06884 0.08469 0.09239 0.00136 0 0 0.24728 ENE 0.09058 0.10553 0.07609 0.00045 0 0 0.27264 ESE 0.08424 0.08469 0.04574 0 0 0 0.21467 SSE 0.02446 0.04257 0.024 0.00091 0 0 0.09194 SSW 0.00906 0.00679 0.00543 0.00045 0 0 0.02174 WSW 0.00951 0.00725 0.00543 0 0 0 0.02219 WNW 0.01449 0.01178 0.00725 0 0 0 0.03351 NNW 0.00996 0.02219 0.03804 0 0 0 0.0702

Output of Dispersion Modeling Results

Annexure- IV

PM10‐ Dispersion Modeling Results

X Y Concentration Elevation Hill Heights Flagpole Aver. Period Source Group Rank Net ID Date [ug/m3] (ZELEV) (ZHILL) (ZFLAG) (AVE) (GRP)

265607.68 2236479.86 0.00308 0 0 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 266607.68 2236479.86 0.00495 3.4 3.4 0 24‐HR ALL 1ST UCART1 1/16/2016 24 hr 267607.68 2236479.86 0.00427 4.8 4.8 0 24‐HR ALL 1ST UCART1 1/26/2016 24 hr 268607.68 2236479.86 0.00771 7.3 7.3 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 269607.68 2236479.86 0.00474 10.6 10.6 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 270607.68 2236479.86 0.00559 15 15 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 271607.68 2236479.86 0.00591 18.1 18.1 0 24‐HR ALL 1ST UCART1 12/26/2015 24 hr 272607.68 2236479.86 0.00661 12 12 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 273607.68 2236479.86 0.00906 14.1 14.1 0 24‐HR ALL 1ST UCART1 1/21/2016 24 hr 274607.68 2236479.86 0.01298 25.4 25.4 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 275607.68 2236479.86 0.01595 29.2 29.2 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2236479.86 0.01147 50.1 50.1 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 277607.68 2236479.86 0.01049 72.3 83 0 24‐HR ALL 1ST UCART1 1/6/2016 24 hr 278607.68 2236479.86 0.00506 60.6 60.6 0 24‐HR ALL 1ST UCART1 12/27/2015 24 hr 279607.68 2236479.86 0.00317 43.4 43.4 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 280607.68 2236479.86 0.00587 36.6 36.6 0 24‐HR ALL 1ST UCART1 12/9/2015 24 hr 281607.68 2236479.86 0.00131 27.8 27.8 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 282607.68 2236479.86 0.0018 30.7 30.7 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 283607.68 2236479.86 0.00202 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 284607.68 2236479.86 0.00327 30.7 30.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 285607.68 2236479.86 0.00124 38 38 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 265607.68 2237479.86 0.00519 3.6 3.6 0 24‐HR ALL 1ST UCART1 1/5/2016 24 hr 266607.68 2237479.86 0.00353 3 3 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 267607.68 2237479.86 0.00617 5.1 5.1 0 24‐HR ALL 1ST UCART1 1/16/2016 24 hr 268607.68 2237479.86 0.00515 9.2 9.2 0 24‐HR ALL 1ST UCART1 12/28/2015 24 hr 269607.68 2237479.86 0.00686 14.7 14.7 0 24‐HR ALL 1ST UCART1 12/29/2015 24 hr 270607.68 2237479.86 0.0064 14.1 14.1 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 271607.68 2237479.86 0.00445 16.4 16.4 0 24‐HR ALL 1ST UCART1 12/31/2015 24 hr 272607.68 2237479.86 0.00723 24 24 0 24‐HR ALL 1ST UCART1 12/27/2015 24 hr 273607.68 2237479.86 0.00783 19.2 19.2 0 24‐HR ALL 1ST UCART1 1/21/2016 24 hr 274607.68 2237479.86 0.01404 21 21 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 275607.68 2237479.86 0.0166 23.2 23.2 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2237479.86 0.00868 34.6 34.6 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 277607.68 2237479.86 0.00549 53.1 53.1 0 24‐HR ALL 1ST UCART1 1/6/2016 24 hr 278607.68 2237479.86 0.00336 48.1 48.1 0 24‐HR ALL 1ST UCART1 12/13/2015 24 hr 279607.68 2237479.86 0.00301 65.3 65.3 0 24‐HR ALL 1ST UCART1 11/8/2015 24 hr 280607.68 2237479.86 0.00398 39.8 39.8 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 281607.68 2237479.86 0.00137 34 34 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 282607.68 2237479.86 0.00219 29.8 29.8 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 283607.68 2237479.86 0.00359 29 29 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 284607.68 2237479.86 0.00147 32.2 32.2 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 285607.68 2237479.86 0.00406 38.2 38.2 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 265607.68 2238479.86 0.00807 3.8 3.8 0 24‐HR ALL 1ST UCART1 1/15/2016 24 hr 266607.68 2238479.86 0.00601 3.8 3.8 0 24‐HR ALL 1ST UCART1 1/5/2016 24 hr 267607.68 2238479.86 0.00409 4.2 4.2 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 268607.68 2238479.86 0.00699 7 7 0 24‐HR ALL 1ST UCART1 1/16/2016 24 hr 269607.68 2238479.86 0.00666 8.3 8.3 0 24‐HR ALL 1ST UCART1 12/28/2015 24 hr 270607.68 2238479.86 0.00589 14.5 14.5 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 271607.68 2238479.86 0.00645 24.7 24.7 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 272607.68 2238479.86 0.00745 28.2 28.2 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 273607.68 2238479.86 0.00914 17.6 17.6 0 24‐HR ALL 1ST UCART1 1/5/2016 24 hr 274607.68 2238479.86 0.01452 22.3 22.3 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 275607.68 2238479.86 0.01711 24.5 24.5 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2238479.86 0.00668 35.7 35.7 0 24‐HR ALL 1ST UCART1 12/27/2015 24 hr 277607.68 2238479.86 0.00591 54 54 0 24‐HR ALL 1ST UCART1 12/17/2015 24 hr 278607.68 2238479.86 0.00453 42.6 42.6 0 24‐HR ALL 1ST UCART1 12/25/2015 24 hr 279607.68 2238479.86 0.00714 51 51 0 24‐HR ALL 1ST UCART1 12/9/2015 24 hr 280607.68 2238479.86 0.00289 66.2 73 0 24‐HR ALL 1ST UCART1 12/25/2015 24 hr 281607.68 2238479.86 0.00314 40.8 87 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr

Discrete Receptor ID

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282607.68 2238479.86 0.00417 29.8 29.8 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 283607.68 2238479.86 0.00192 29.7 29.7 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 284607.68 2238479.86 0.00329 34.1 34.1 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 285607.68 2238479.86 0.00434 36.4 36.4 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 265607.68 2239479.86 0.00661 15 15 0 24‐HR ALL 1ST UCART1 1/24/2016 24 hr 266607.68 2239479.86 0.00862 14.5 14.5 0 24‐HR ALL 1ST UCART1 1/15/2016 24 hr 267607.68 2239479.86 0.00687 11.6 11.6 0 24‐HR ALL 1ST UCART1 1/5/2016 24 hr 268607.68 2239479.86 0.00481 15.2 15.2 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 269607.68 2239479.86 0.00725 11 11 0 24‐HR ALL 1ST UCART1 12/23/2015 24 hr 270607.68 2239479.86 0.01071 14.3 14.3 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 271607.68 2239479.86 0.0099 33.8 33.8 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 272607.68 2239479.86 0.00699 32.3 32.3 0 24‐HR ALL 1ST UCART1 12/26/2015 24 hr 273607.68 2239479.86 0.00979 26.9 26.9 0 24‐HR ALL 1ST UCART1 1/5/2016 24 hr 274607.68 2239479.86 0.01389 22.3 22.3 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 275607.68 2239479.86 0.01715 26.4 26.4 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2239479.86 0.00517 31.8 31.8 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 277607.68 2239479.86 0.00537 30.8 30.8 0 24‐HR ALL 1ST UCART1 12/27/2015 24 hr 278607.68 2239479.86 0.00418 59.3 70 0 24‐HR ALL 1ST UCART1 11/8/2015 24 hr 279607.68 2239479.86 0.00364 48.7 48.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 280607.68 2239479.86 0.00375 51.8 94 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 281607.68 2239479.86 0.00497 31.2 31.2 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 282607.68 2239479.86 0.00256 25.8 25.8 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 283607.68 2239479.86 0.00216 28.1 28.1 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 284607.68 2239479.86 0.0045 31.2 31.2 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 285607.68 2239479.86 0.00667 35.9 35.9 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 265607.68 2240479.86 0.00894 13.9 13.9 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 266607.68 2240479.86 0.00691 16.3 16.3 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 267607.68 2240479.86 0.00927 16 16 0 24‐HR ALL 1ST UCART1 1/24/2016 24 hr 268607.68 2240479.86 0.00868 31.2 31.2 0 24‐HR ALL 1ST UCART1 1/4/2016 24 hr 269607.68 2240479.86 0.00612 17.4 17.4 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 270607.68 2240479.86 0.00712 12.2 12.2 0 24‐HR ALL 1ST UCART1 12/28/2015 24 hr 271607.68 2240479.86 0.01299 38.3 38.3 0 24‐HR ALL 1ST UCART1 12/29/2015 24 hr 272607.68 2240479.86 0.00775 32.7 32.7 0 24‐HR ALL 1ST UCART1 12/31/2015 24 hr 273607.68 2240479.86 0.00856 25.7 25.7 0 24‐HR ALL 1ST UCART1 1/7/2016 24 hr 274607.68 2240479.86 0.01164 21.2 21.2 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 275607.68 2240479.86 0.01633 23.8 23.8 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2240479.86 0.0054 28.9 28.9 0 24‐HR ALL 1ST UCART1 12/10/2015 24 hr 277607.68 2240479.86 0.00484 43.5 69 0 24‐HR ALL 1ST UCART1 12/18/2015 24 hr 278607.68 2240479.86 0.00634 47.9 47.9 0 24‐HR ALL 1ST UCART1 12/9/2015 24 hr 279607.68 2240479.86 0.00296 55.9 55.9 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 280607.68 2240479.86 0.00677 38.1 38.1 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 281607.68 2240479.86 0.00382 29.7 29.7 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 282607.68 2240479.86 0.0038 33 33 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 283607.68 2240479.86 0.006 30.9 30.9 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 284607.68 2240479.86 0.0092 32.5 32.5 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 285607.68 2240479.86 0.00633 36.1 36.1 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 265607.68 2241479.86 0.00521 5.4 5.4 0 24‐HR ALL 1ST UCART1 1/15/2016 24 hr 266607.68 2241479.86 0.01143 11.8 11.8 0 24‐HR ALL 1ST UCART1 1/23/2016 24 hr 267607.68 2241479.86 0.00972 16.6 16.6 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 268607.68 2241479.86 0.01156 26.4 93 0 24‐HR ALL 1ST UCART1 1/24/2016 24 hr 269607.68 2241479.86 0.00924 26.3 93 0 24‐HR ALL 1ST UCART1 1/4/2016 24 hr 270607.68 2241479.86 0.0082 24.7 24.7 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 271607.68 2241479.86 0.01085 24.3 24.3 0 24‐HR ALL 1ST UCART1 12/28/2015 24 hr 272607.68 2241479.86 0.01341 65.9 105 0 24‐HR ALL 1ST UCART1 1/10/2016 24 hr 273607.68 2241479.86 0.01134 33.8 33.8 0 24‐HR ALL 1ST UCART1 12/22/2015 24 hr 274607.68 2241479.86 0.01643 25.4 25.4 0 24‐HR ALL 1ST UCART1 1/4/2016 24 hr 275607.68 2241479.86 0.01425 27.1 27.1 0 24‐HR ALL 1ST UCART1 1/20/2016 24 hr 276607.68 2241479.86 0.00679 26.6 26.6 0 24‐HR ALL 1ST UCART1 12/17/2015 24 hr 277607.68 2241479.86 0.00591 33.3 33.3 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 278607.68 2241479.86 0.00157 44.2 44.2 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 279607.68 2241479.86 0.00744 41.9 41.9 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 280607.68 2241479.86 0.0061 34.6 34.6 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr

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281607.68 2241479.86 0.00542 28.4 28.4 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 282607.68 2241479.86 0.00744 28.7 28.7 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 283607.68 2241479.86 0.0107 32.5 32.5 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 284607.68 2241479.86 0.00721 38 38 0 24‐HR ALL 1ST UCART1 12/17/2015 24 hr 285607.68 2241479.86 0.00831 32.9 32.9 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 265607.68 2242479.86 0.00695 5.6 5.6 0 24‐HR ALL 1ST UCART1 1/19/2016 24 hr 266607.68 2242479.86 0.00507 10.6 10.6 0 24‐HR ALL 1ST UCART1 1/9/2016 24 hr 267607.68 2242479.86 0.00625 11.9 11.9 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 268607.68 2242479.86 0.01261 19.1 19.1 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 269607.68 2242479.86 0.00888 25.5 25.5 0 24‐HR ALL 1ST UCART1 1/24/2016 24 hr 270607.68 2242479.86 0.0096 29.4 29.4 0 24‐HR ALL 1ST UCART1 1/4/2016 24 hr 271607.68 2242479.86 0.0108 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 272607.68 2242479.86 0.01785 44.1 44.1 0 24‐HR ALL 1ST UCART1 12/28/2015 24 hr 273607.68 2242479.86 0.0096 29.1 29.1 0 24‐HR ALL 1ST UCART1 12/31/2015 24 hr 274607.68 2242479.86 0.0171 23.6 23.6 0 24‐HR ALL 1ST UCART1 1/4/2016 24 hr 275607.68 2242479.86 0.01242 24.3 24.3 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 276607.68 2242479.86 0.00623 31.4 31.4 0 24‐HR ALL 1ST UCART1 12/27/2015 24 hr 277607.68 2242479.86 0.0076 35.2 35.2 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 278607.68 2242479.86 0.00777 37.8 37.8 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 279607.68 2242479.86 0.00977 41 41 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 280607.68 2242479.86 0.00744 28.8 28.8 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 281607.68 2242479.86 0.01351 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 282607.68 2242479.86 0.00665 31.3 31.3 0 24‐HR ALL 1ST UCART1 12/17/2015 24 hr 283607.68 2242479.86 0.00856 27.8 27.8 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 284607.68 2242479.86 0.00138 32.9 32.9 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 285607.68 2242479.86 0.00171 39.2 39.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2243479.86 0.00903 7.4 7.4 0 24‐HR ALL 1ST UCART1 1/14/2016 24 hr 266607.68 2243479.86 0.00861 12.6 12.6 0 24‐HR ALL 1ST UCART1 1/25/2016 24 hr 267607.68 2243479.86 0.0076 18.1 18.1 0 24‐HR ALL 1ST UCART1 1/19/2016 24 hr 268607.68 2243479.86 0.00608 16.4 16.4 0 24‐HR ALL 1ST UCART1 1/14/2016 24 hr 269607.68 2243479.86 0.00964 22.7 22.7 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 270607.68 2243479.86 0.0117 30.3 30.3 0 24‐HR ALL 1ST UCART1 1/3/2016 24 hr 271607.68 2243479.86 0.03557 50.3 160 0 24‐HR ALL 1ST UCART1 1/15/2016 24 hr 272607.68 2243479.86 0.01573 46.1 160 0 24‐HR ALL 1ST UCART1 1/16/2016 24 hr 273607.68 2243479.86 0.01758 32.3 32.3 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 274607.68 2243479.86 0.01379 33.4 33.4 0 24‐HR ALL 1ST UCART1 11/18/2015 24 hr 275607.68 2243479.86 0.00877 23 23 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 276607.68 2243479.86 0.01021 39.7 39.7 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 277607.68 2243479.86 0.0083 45.4 72 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 278607.68 2243479.86 0.01173 44.6 145 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 279607.68 2243479.86 0.00994 29.6 29.6 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 280607.68 2243479.86 0.00978 31.8 31.8 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 281607.68 2243479.86 0.00966 29.4 29.4 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 282607.68 2243479.86 0.00152 30.1 30.1 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2243479.86 0.00388 30.8 30.8 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 284607.68 2243479.86 0.00323 35.1 35.1 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 285607.68 2243479.86 0.00495 37.6 37.6 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 265607.68 2244479.86 0.00747 9.4 9.4 0 24‐HR ALL 1ST UCART1 1/23/2016 24 hr 266607.68 2244479.86 0.01111 13.9 13.9 0 24‐HR ALL 1ST UCART1 1/23/2016 24 hr 267607.68 2244479.86 0.0078 14.5 14.5 0 24‐HR ALL 1ST UCART1 1/19/2016 24 hr 268607.68 2244479.86 0.00966 14.5 14.5 0 24‐HR ALL 1ST UCART1 1/14/2016 24 hr 269607.68 2244479.86 0.01191 21.2 21.2 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 270607.68 2244479.86 0.01037 35.7 133 0 24‐HR ALL 1ST UCART1 1/19/2016 24 hr 271607.68 2244479.86 0.04997 56.1 160 0 24‐HR ALL 1ST UCART1 1/23/2016 24 hr 272607.68 2244479.86 0.08062 76.6 160 0 24‐HR ALL 1ST UCART1 1/2/2016 24 hr 273607.68 2244479.86 0.02125 36.5 36.5 0 24‐HR ALL 1ST UCART1 12/23/2015 24 hr 274607.68 2244479.86 0.02107 31.1 31.1 0 24‐HR ALL 1ST UCART1 12/31/2015 24 hr 275607.68 2244479.86 0.01385 33 33 0 24‐HR ALL 1ST UCART1 11/17/2015 24 hr 276607.68 2244479.86 0.00606 31.2 31.2 0 24‐HR ALL 1ST UCART1 12/3/2015 24 hr 277607.68 2244479.86 0.00736 46.1 145 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 278607.68 2244479.86 0.0014 121.9 139 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 279607.68 2244479.86 0.00951 32.1 32.1 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr

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280607.68 2244479.86 0.00436 23 23 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 281607.68 2244479.86 0.00403 21.5 21.5 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 282607.68 2244479.86 0.00479 28 28 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 283607.68 2244479.86 0.0073 30.5 30.5 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 284607.68 2244479.86 0.00628 31.7 31.7 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 285607.68 2244479.86 0.00405 33.5 33.5 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 265607.68 2245479.86 0.01525 0.4 0.4 0 24‐HR ALL 1ST UCART1 1/11/2016 24 hr 266607.68 2245479.86 0.01802 12.5 12.5 0 24‐HR ALL 1ST UCART1 1/11/2016 24 hr 267607.68 2245479.86 0.01866 9.4 9.4 0 24‐HR ALL 1ST UCART1 1/11/2016 24 hr 268607.68 2245479.86 0.01665 10.2 10.2 0 24‐HR ALL 1ST UCART1 1/11/2016 24 hr 269607.68 2245479.86 0.01217 19.2 19.2 0 24‐HR ALL 1ST UCART1 1/11/2016 24 hr 270607.68 2245479.86 0.02178 47.1 133 0 24‐HR ALL 1ST UCART1 1/23/2016 24 hr 271607.68 2245479.86 0.01289 27.3 133 0 24‐HR ALL 1ST UCART1 1/19/2016 24 hr 272607.68 2245479.86 0.02876 49.1 49.1 0 24‐HR ALL 1ST UCART1 1/25/2016 24 hr 273607.68 2245479.86 0.0288 40.8 40.8 0 24‐HR ALL 1ST UCART1 11/14/2015 24 hr 274607.68 2245479.86 0.03522 34 34 0 24‐HR ALL 1ST UCART1 11/13/2015 24 hr 275607.68 2245479.86 0.02157 34.1 34.1 0 24‐HR ALL 1ST UCART1 12/8/2015 24 hr 276607.68 2245479.86 0.00978 35 35 0 24‐HR ALL 1ST UCART1 12/17/2015 24 hr 277607.68 2245479.86 0.00535 48.2 48.2 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 278607.68 2245479.86 0.00786 31.5 145 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 279607.68 2245479.86 0.00989 24.9 24.9 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 280607.68 2245479.86 0.00559 20.8 20.8 0 24‐HR ALL 1ST UCART1 1/1/2016 24 hr 281607.68 2245479.86 0.00418 22.4 22.4 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 282607.68 2245479.86 0.0057 32.2 32.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2245479.86 0.00562 26.7 26.7 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2245479.86 0.00506 27.7 27.7 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2245479.86 0.00429 33.3 33.3 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2246479.86 0.00838 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 266607.68 2246479.86 0.00889 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 267607.68 2246479.86 0.00929 3.5 3.5 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 268607.68 2246479.86 0.01034 7.7 7.7 0 24‐HR ALL 1ST UCART1 12/4/2015 24 hr 269607.68 2246479.86 0.01213 16.5 16.5 0 24‐HR ALL 1ST UCART1 12/4/2015 24 hr 270607.68 2246479.86 0.01429 19 19 0 24‐HR ALL 1ST UCART1 12/4/2015 24 hr 271607.68 2246479.86 0.0168 23.3 23.3 0 24‐HR ALL 1ST UCART1 12/4/2015 24 hr 272607.68 2246479.86 0.0225 42.4 93 0 24‐HR ALL 1ST UCART1 12/4/2015 24 hr 273607.68 2246479.86 0.07001 49.1 49.1 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 274607.68 2246479.86 0.07638 39.2 39.2 0 24‐HR ALL 1ST UCART1 11/19/2015 24 hr

AQ (HENI) 275607.68 2246479.86 0.01986 35.6 35.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 276607.68 2246479.86 0.00356 42.1 42.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 277607.68 2246479.86 0.00291 32.7 32.7 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 278607.68 2246479.86 0.00421 27.4 27.4 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 279607.68 2246479.86 0.00443 21.8 21.8 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 280607.68 2246479.86 0.00423 25.2 25.2 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 281607.68 2246479.86 0.00392 25.1 25.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 282607.68 2246479.86 0.00362 28.6 28.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 283607.68 2246479.86 0.00338 31 31 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 284607.68 2246479.86 0.00305 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 285607.68 2246479.86 0.00276 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 265607.68 2247479.86 0.00677 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 266607.68 2247479.86 0.0074 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 267607.68 2247479.86 0.00741 4.4 4.4 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 268607.68 2247479.86 0.01123 10.3 10.3 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 269607.68 2247479.86 0.01431 9.4 9.4 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 270607.68 2247479.86 0.01403 17.5 17.5 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 271607.68 2247479.86 0.01115 30.1 30.1 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 272607.68 2247479.86 0.01408 31 31 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 273607.68 2247479.86 0.0565 53 132 0 24‐HR ALL 1ST UCART1 1/31/2016 24 hr 274607.68 2247479.86 0.06773 57.1 146 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 275607.68 2247479.86 0.01476 45.4 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2247479.86 0.00253 33 219 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 277607.68 2247479.86 0.02482 34.8 34.8 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 278607.68 2247479.86 0.01746 26.5 26.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr

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279607.68 2247479.86 0.00348 23.2 23.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 280607.68 2247479.86 0.00126 28.4 28.4 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 281607.68 2247479.86 0.00073 29.1 29.1 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 282607.68 2247479.86 0.00048 31.7 31.7 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2247479.86 0.00035 25.7 25.7 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2247479.86 0.00027 24.9 24.9 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2247479.86 0.00023 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2248479.86 0.00781 0 0 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 266607.68 2248479.86 0.00747 0 0 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 267607.68 2248479.86 0.00594 0.9 0.9 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 268607.68 2248479.86 0.00556 12.9 12.9 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 269607.68 2248479.86 0.00748 15.4 15.4 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 270607.68 2248479.86 0.0126 16.3 16.3 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 271607.68 2248479.86 0.0309 26.2 26.2 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 272607.68 2248479.86 0.01095 26 26 0 24‐HR ALL 1ST UCART1 11/1/2015 24 hr 273607.68 2248479.86 0.01288 30.8 219 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 274607.68 2248479.86 0.00528 89 219 0 24‐HR ALL 1ST UCART1 12/14/2015 24 hr 275607.68 2248479.86 0.00485 102.8 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2248479.86 0.0026 34.5 219 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 277607.68 2248479.86 0.00072 25.5 25.5 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 278607.68 2248479.86 0.00159 19.1 19.1 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 279607.68 2248479.86 0.0161 28.5 28.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 280607.68 2248479.86 0.02257 30 30 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 281607.68 2248479.86 0.01612 31.7 31.7 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 282607.68 2248479.86 0.00701 32.3 32.3 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2248479.86 0.00284 14.4 14.4 0 24‐HR ALL 1ST UCART1 12/20/2015 24 hr 284607.68 2248479.86 0.00082 25.6 25.6 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2248479.86 0.00051 31.4 31.4 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2249479.86 0.00357 0 0 0 24‐HR ALL 1ST UCART1 11/19/2015 24 hr 266607.68 2249479.86 0.0056 0 0 0 24‐HR ALL 1ST UCART1 1/30/2016 24 hr 267607.68 2249479.86 0.00761 0 0 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 268607.68 2249479.86 0.00918 9.2 9.2 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 269607.68 2249479.86 0.01776 14.4 14.4 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 270607.68 2249479.86 0.01487 18.8 18.8 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 271607.68 2249479.86 0.00675 25.3 25.3 0 24‐HR ALL 1ST UCART1 11/1/2015 24 hr 272607.68 2249479.86 0.00958 15.6 15.6 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 273607.68 2249479.86 0.00909 24.2 219 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 274607.68 2249479.86 0.01138 33.4 219 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2249479.86 0.01027 84.2 219 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 276607.68 2249479.86 0.01036 39.9 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 277607.68 2249479.86 0.00062 23.6 197 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 278607.68 2249479.86 0.00047 17.9 17.9 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 279607.68 2249479.86 0.00057 27.4 27.4 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 280607.68 2249479.86 0.00116 19.6 19.6 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 281607.68 2249479.86 0.00834 21 21 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 282607.68 2249479.86 0.01882 14 14 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2249479.86 0.01388 28.4 28.4 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2249479.86 0.0126 33.6 33.6 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2249479.86 0.00815 35.2 35.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2250479.86 0.00619 0 0 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 266607.68 2250479.86 0.00703 0 0 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 267607.68 2250479.86 0.01184 0 0 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 268607.68 2250479.86 0.01124 9 9 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 269607.68 2250479.86 0.01108 22.3 22.3 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 270607.68 2250479.86 0.00403 13.6 13.6 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 271607.68 2250479.86 0.00594 14.4 14.4 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 272607.68 2250479.86 0.00337 17 17 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 273607.68 2250479.86 0.0047 15.6 15.6 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 274607.68 2250479.86 0.00573 21.9 219 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2250479.86 0.00303 30 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2250479.86 0.001 90.9 135 0 24‐HR ALL 1ST UCART1 12/25/2015 24 hr 277607.68 2250479.86 0.00723 18.1 123 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr

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278607.68 2250479.86 0.00046 21.9 21.9 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 279607.68 2250479.86 0.00034 6.2 26 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 280607.68 2250479.86 0.00049 15.2 15.2 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 281607.68 2250479.86 0.00045 3.5 3.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 282607.68 2250479.86 0.00089 23.3 23.3 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2250479.86 0.005 30.9 30.9 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2250479.86 0.01381 30.2 30.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2250479.86 0.01433 34 34 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2251479.86 0.0092 0 0 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 266607.68 2251479.86 0.01195 0 0 0 24‐HR ALL 1ST UCART1 11/5/2015 24 hr 267607.68 2251479.86 0.00997 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 268607.68 2251479.86 0.00381 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 269607.68 2251479.86 0.0035 6.4 6.4 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 270607.68 2251479.86 0.00373 10 10 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 271607.68 2251479.86 0.00352 7.8 7.8 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 272607.68 2251479.86 0.00594 8.7 8.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 273607.68 2251479.86 0.00347 11.3 11.3 0 24‐HR ALL 1ST UCART1 12/14/2015 24 hr 274607.68 2251479.86 0.00561 20.1 20.1 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2251479.86 0.00157 22.6 22.6 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2251479.86 0.00516 21.1 21.1 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 277607.68 2251479.86 0.00639 30.2 57 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 278607.68 2251479.86 0.00105 23.6 23.6 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 279607.68 2251479.86 0.00036 20.8 20.8 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 280607.68 2251479.86 0.00027 19.9 19.9 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 281607.68 2251479.86 0.0004 24.5 24.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 282607.68 2251479.86 0.00063 21.8 21.8 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 283607.68 2251479.86 0.0004 26.5 26.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2251479.86 0.00074 32.9 32.9 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 285607.68 2251479.86 0.00308 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2252479.86 0.00622 0 0 0 24‐HR ALL 1ST UCART1 1/31/2016 24 hr 266607.68 2252479.86 0.00895 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 267607.68 2252479.86 0.00325 0 0 0 24‐HR ALL 1ST UCART1 11/1/2015 24 hr 268607.68 2252479.86 0.00331 0 0 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 269607.68 2252479.86 0.00336 0 0 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 270607.68 2252479.86 0.00326 0 0 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 271607.68 2252479.86 0.00401 0.4 0.4 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 272607.68 2252479.86 0.00301 4.8 4.8 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 273607.68 2252479.86 0.00273 14 14 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 274607.68 2252479.86 0.00435 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2252479.86 0.00196 67.7 75 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 276607.68 2252479.86 0.00552 18 18 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 277607.68 2252479.86 0.00041 22.6 22.6 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 278607.68 2252479.86 0.00877 21.6 21.6 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 279607.68 2252479.86 0.00039 14.4 14.4 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 280607.68 2252479.86 0.0003 19.4 19.4 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 281607.68 2252479.86 0.00023 22.3 22.3 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 282607.68 2252479.86 0.00031 24.9 24.9 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 283607.68 2252479.86 0.00076 30.9 30.9 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 284607.68 2252479.86 0.00049 27.8 27.8 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 285607.68 2252479.86 0.00033 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 265607.68 2253479.86 0.00481 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 266607.68 2253479.86 0.00271 0 0 0 24‐HR ALL 1ST UCART1 11/1/2015 24 hr 267607.68 2253479.86 0.003 0 0 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 268607.68 2253479.86 0.00286 0 0 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 269607.68 2253479.86 0.00374 0 0 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 270607.68 2253479.86 0.0033 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 271607.68 2253479.86 0.00405 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 272607.68 2253479.86 0.003 9.7 9.7 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 273607.68 2253479.86 0.0041 10 10 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 274607.68 2253479.86 0.00246 18.3 98 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2253479.86 0.00213 67.6 75 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 276607.68 2253479.86 0.0064 14.4 14.4 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr

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277607.68 2253479.86 0.00042 18.2 18.2 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 278607.68 2253479.86 0.00481 19.3 19.3 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 279607.68 2253479.86 0.00252 20.4 20.4 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 280607.68 2253479.86 0.00035 21.9 21.9 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 281607.68 2253479.86 0.00026 22.8 22.8 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 282607.68 2253479.86 0.0002 24.2 24.2 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 283607.68 2253479.86 0.00027 28.2 28.2 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 284607.68 2253479.86 0.00068 26.1 26.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 285607.68 2253479.86 0.00077 29.9 29.9 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 265607.68 2254479.86 0.00222 0 0 0 24‐HR ALL 1ST UCART1 11/1/2015 24 hr 266607.68 2254479.86 0.00267 0 0 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 267607.68 2254479.86 0.00239 0 0 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 268607.68 2254479.86 0.00367 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 269607.68 2254479.86 0.00359 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 270607.68 2254479.86 0.00302 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 271607.68 2254479.86 0.00333 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 272607.68 2254479.86 0.00209 0 15 0 24‐HR ALL 1ST UCART1 12/14/2015 24 hr 273607.68 2254479.86 0.00478 14 14 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 274607.68 2254479.86 0.00131 11.9 11.9 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2254479.86 0.00102 15.7 15.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 276607.68 2254479.86 0.00614 20.4 20.4 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 277607.68 2254479.86 0.00212 6.2 6.2 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 278607.68 2254479.86 0.00037 6.9 6.9 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 279607.68 2254479.86 0.00813 17 17 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 280607.68 2254479.86 0.00059 21.5 21.5 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 281607.68 2254479.86 0.00032 30.7 30.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 282607.68 2254479.86 0.00023 26.7 26.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 283607.68 2254479.86 0.00018 28.4 28.4 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 284607.68 2254479.86 0.00023 23.6 23.6 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 285607.68 2254479.86 0.00051 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 265607.68 2255479.86 0.00235 0 0 0 24‐HR ALL 1ST UCART1 11/6/2015 24 hr 266607.68 2255479.86 0.002 0 0 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 267607.68 2255479.86 0.00353 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 268607.68 2255479.86 0.00245 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 269607.68 2255479.86 0.00218 0 0 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 270607.68 2255479.86 0.00298 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 271607.68 2255479.86 0.00171 0 0 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 272607.68 2255479.86 0.0016 0 0 0 24‐HR ALL 1ST UCART1 12/14/2015 24 hr 273607.68 2255479.86 0.00329 9 9 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 274607.68 2255479.86 0.00069 14.9 14.9 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 275607.68 2255479.86 0.00089 17.4 17.4 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 276607.68 2255479.86 0.00337 15.7 15.7 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 277607.68 2255479.86 0.0041 15.4 15.4 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 278607.68 2255479.86 0.00024 18.6 18.6 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 279607.68 2255479.86 0.00401 23.7 23.7 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 280607.68 2255479.86 0.00406 21 21 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 281607.68 2255479.86 0.0003 27.9 27.9 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 282607.68 2255479.86 0.00028 20.2 20.2 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 283607.68 2255479.86 0.00021 30.9 30.9 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 284607.68 2255479.86 0.00017 21.3 21.3 0 24‐HR ALL 1ST UCART1 12/25/2015 24 hr 285607.68 2255479.86 0.00021 25.6 25.6 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 265607.68 2256479.86 0.00169 0 0 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 266607.68 2256479.86 0.00293 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 267607.68 2256479.86 0.00206 0 0 0 24‐HR ALL 1ST UCART1 11/4/2015 24 hr 268607.68 2256479.86 0.00308 0 0 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 269607.68 2256479.86 0.00206 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 270607.68 2256479.86 0.00338 0 0 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 271607.68 2256479.86 0.00231 0 0 0 24‐HR ALL 1ST UCART1 12/1/2015 24 hr 272607.68 2256479.86 0.00178 0 0 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 273607.68 2256479.86 0.00195 14.8 14.8 0 24‐HR ALL 1ST UCART1 12/16/2015 24 hr 274607.68 2256479.86 0.00051 13.8 13.8 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 275607.68 2256479.86 0.00076 12.7 12.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr

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276607.68 2256479.86 0.00198 11.4 11.4 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 277607.68 2256479.86 0.00309 12.8 12.8 0 24‐HR ALL 1ST UCART1 12/19/2015 24 hr 278607.68 2256479.86 0.00028 18.8 18.8 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 279607.68 2256479.86 0.00042 18.4 18.4 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 280607.68 2256479.86 0.0072 15.7 15.7 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 281607.68 2256479.86 0.0011 20.5 20.5 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 282607.68 2256479.86 0.00029 25.7 25.7 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 283607.68 2256479.86 0.00026 24.6 24.6 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 284607.68 2256479.86 0.00018 21 21 0 24‐HR ALL 1ST UCART1 12/7/2015 24 hr 285607.68 2256479.86 0.00017 21.3 21.3 0 24‐HR ALL 1ST UCART1 12/25/2015 24 hr

AQ (HENI) 275607.68 2246479.86 0.01986 35.57 35.57 0 24‐HR ALL 1ST 12/5/2015 24 hr AQ (BHILAD) 279916.74 2244872.28 0.00631 22.92 22.92 0 24‐HR ALL 1ST 12/20/2015 24 hrAQ (PUNAT) 276752.3 2247598.21 0.0021 34.31 84 0 24‐HR ALL 1ST 12/21/2015 24 hrAQ (KANADU) 273710.9 2248366.37 0.0129 31.04 219 0 24‐HR ALL 1ST 11/4/2015 24 hr AQ (SARAI) 271823.72 2244130.7 0.04076 52.28 160 0 24‐HR ALL 1ST 1/2/2016 24 hr AQ (DAHELI) 277578.1 2242240.09 0.00813 30.46 30.46 0 24‐HR ALL 1ST 12/9/2015 24 hr DW (PDISCR) 275108.63 2246122.33 0.06653 35.92 35.92 0 24‐HR ALL 1ST 11/21/2015 24 hrDW (PDISCR) 274761.3 2245762.66 0.05156 34.43 34.43 0 24‐HR ALL 1ST 11/13/2015 24 hrDW (PDISCR) 274413.97 2245402.99 0.03727 35.65 35.65 0 24‐HR ALL 1ST 11/13/2015 24 hrDW (PDISCR) 274066.64 2245043.32 0.02038 33.65 33.65 0 24‐HR ALL 1ST 11/13/2015 24 hrDW (PDISCR) 273719.31 2244683.65 0.02284 35.15 35.15 0 24‐HR ALL 1ST 12/23/2015 24 hrDW (PDISCR) 273371.98 2244323.98 0.02549 39.02 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW (PDISCR) 273024.66 2243964.31 0.01865 41.83 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW (PDISCR) 272677.33 2243604.64 0.01927 48.97 160 0 24‐HR ALL 1ST 1/16/2016 24 hr DW (PDISCR) 272330 2243244.97 0.01834 51.89 160 0 24‐HR ALL 1ST 1/6/2016 24 hr DW (PDISCR) 271982.67 2242885.3 0.01367 41.47 160 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 271635.34 2242525.63 0.01096 30.68 30.68 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 271288.01 2242165.96 0.00976 22.15 22.15 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 270940.68 2241806.29 0.0089 18.65 18.65 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 270593.35 2241446.62 0.00825 24.64 24.64 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 270246.02 2241086.95 0.00748 20.36 20.36 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 269898.69 2240727.28 0.00687 20.69 20.69 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 269551.36 2240367.61 0.00628 17.64 17.64 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 269204.03 2240007.94 0.00579 17.16 17.16 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 268856.71 2239648.27 0.00533 14.69 14.69 0 24‐HR ALL 1ST 12/8/2015 24 hr DW (PDISCR) 268509.38 2239288.6 0.00496 15.92 15.92 0 24‐HR ALL 1ST 12/8/2015 24 hr

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SO2‐ Dispersion Modeling Results




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AQ (Project) 275607.68 2246479.86 0.03438 35.6 35.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 276607.68 2246479.86 0.00877 42.1 42.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 277607.68 2246479.86 0.00969 32.7 32.7 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 278607.68 2246479.86 0.01608 27.4 27.4 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 279607.68 2246479.86 0.01737 21.8 21.8 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 280607.68 2246479.86 0.01678 25.2 25.2 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 281607.68 2246479.86 0.01564 25.1 25.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 282607.68 2246479.86 0.01445 28.6 28.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 283607.68 2246479.86 0.01353 31 31 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 284607.68 2246479.86 0.01223 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 285607.68 2246479.86 0.01106 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 265607.68 2247479.86 0.02731 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 266607.68 2247479.86 0.02984 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 267607.68 2247479.86 0.03039 4.4 4.4 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 268607.68 2247479.86 0.04623 10.3 10.3 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 269607.68 2247479.86 0.05324 9.4 9.4 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 270607.68 2247479.86 0.05178 17.5 17.5 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 271607.68 2247479.86 0.04207 30.1 30.1 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 272607.68 2247479.86 0.05642 31 31 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 273607.68 2247479.86 0.2249 53 132 0 24‐HR ALL 1ST UCART1 1/31/2016 24 hr 274607.68 2247479.86 0.26243 57.1 146 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 275607.68 2247479.86 0.0457 45.4 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2247479.86 0.00483 33 219 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 277607.68 2247479.86 0.0918 34.8 34.8 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 278607.68 2247479.86 0.06432 26.5 26.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr

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AQ (Project) 275607.68 2246479.86 0.03437 35.57 35.57 0 24‐HR ALL 1ST 12/5/2015 24 hr AQ (Bhilad) 279916.74 2244872.28 0.02591 22.92 22.92 0 24‐HR ALL 1ST 12/20/2015 24 hrAQ (Punat) 276752.3 2247598.21 0.00392 34.31 84 0 24‐HR ALL 1ST 12/21/2015 24 hrAQ (Kanadu) 273710.9 2248366.37 0.05268 31.04 219 0 24‐HR ALL 1ST 11/4/2015 24 hr AQ (Sarai) 271823.72 2244130.7 0.16885 52.28 160 0 24‐HR ALL 1ST 1/2/2016 24 hr AQ (Dehali) 277578.1 2242240.09 0.03375 30.46 30.46 0 24‐HR ALL 1ST 12/9/2015 24 hr DW1 (PDISCR) 275108.63 2246122.33 0.23146 35.92 35.92 0 24‐HR ALL 1ST 11/21/2015 24 hrDW2 (PDISCR) 274761.3 2245762.66 0.19004 34.43 34.43 0 24‐HR ALL 1ST 11/13/2015 24 hrDW3 (PDISCR) 274413.97 2245402.99 0.13448 35.65 35.65 0 24‐HR ALL 1ST 11/13/2015 24 hrDW4 (PDISCR) 274066.64 2245043.32 0.07476 33.65 33.65 0 24‐HR ALL 1ST 12/23/2015 24 hrDW5 (PDISCR) 273719.31 2244683.65 0.09259 35.15 35.15 0 24‐HR ALL 1ST 12/23/2015 24 hrDW6 (PDISCR) 273371.98 2244323.98 0.10408 39.02 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW7 (PDISCR) 273024.66 2243964.31 0.07621 41.83 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW8 (PDISCR) 272677.33 2243604.64 0.07743 48.97 160 0 24‐HR ALL 1ST 1/16/2016 24 hr DW9 (PDISCR) 272330 2243244.97 0.07622 51.89 160 0 24‐HR ALL 1ST 1/6/2016 24 hr DW10 (PDISCR) 271982.67 2242885.3 0.05025 41.47 160 0 24‐HR ALL 1ST 12/8/2015 24 hr DW11 (PDISCR) 271635.34 2242525.63 0.03971 30.68 30.68 0 24‐HR ALL 1ST 12/8/2015 24 hr DW12 (PDISCR) 271288.01 2242165.96 0.0354 22.15 22.15 0 24‐HR ALL 1ST 12/8/2015 24 hr DW13 (PDISCR) 270940.68 2241806.29 0.03224 18.65 18.65 0 24‐HR ALL 1ST 12/8/2015 24 hr DW14 (PDISCR) 270593.35 2241446.62 0.02976 24.64 24.64 0 24‐HR ALL 1ST 12/8/2015 24 hr DW15 (PDISCR) 270246.02 2241086.95 0.02689 20.36 20.36 0 24‐HR ALL 1ST 12/8/2015 24 hr DW16 (PDISCR) 269898.69 2240727.28 0.02458 20.69 20.69 0 24‐HR ALL 1ST 12/8/2015 24 hr DW17 (PDISCR) 269551.36 2240367.61 0.02246 17.64 17.64 0 24‐HR ALL 1ST 1/7/2016 24 hr DW18 (PDISCR) 269204.03 2240007.94 0.02113 17.16 17.16 0 24‐HR ALL 1ST 1/7/2016 24 hr DW19 (PDISCR) 268856.71 2239648.27 0.01989 14.69 14.69 0 24‐HR ALL 1ST 1/7/2016 24 hr DW20 (PDISCR) 268509.38 2239288.6 0.01875 15.92 15.92 0 24‐HR ALL 1ST 1/7/2016 24 hr

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NOx ‐ Dispersion Modeling Results




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Page 2



Page 3



AQ (HENI) 275607.68 2246479.86 0.25029 35.6 35.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 276607.68 2246479.86 0.06433 42.1 42.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 277607.68 2246479.86 0.07137 32.7 32.7 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 278607.68 2246479.86 0.11857 27.4 27.4 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 279607.68 2246479.86 0.12814 21.8 21.8 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 280607.68 2246479.86 0.12377 25.2 25.2 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 281607.68 2246479.86 0.11539 25.1 25.1 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 282607.68 2246479.86 0.10662 28.6 28.6 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 283607.68 2246479.86 0.09983 31 31 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 284607.68 2246479.86 0.09027 29.5 29.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 285607.68 2246479.86 0.0816 27.5 27.5 0 24‐HR ALL 1ST UCART1 12/5/2015 24 hr 265607.68 2247479.86 0.20149 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 266607.68 2247479.86 0.22013 0 0 0 24‐HR ALL 1ST UCART1 1/27/2016 24 hr 267607.68 2247479.86 0.22428 4.4 4.4 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 268607.68 2247479.86 0.34117 10.3 10.3 0 24‐HR ALL 1ST UCART1 1/18/2016 24 hr 269607.68 2247479.86 0.39248 9.4 9.4 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 270607.68 2247479.86 0.3817 17.5 17.5 0 24‐HR ALL 1ST UCART1 1/28/2016 24 hr 271607.68 2247479.86 0.31016 30.1 30.1 0 24‐HR ALL 1ST UCART1 11/10/2015 24 hr 272607.68 2247479.86 0.41628 31 31 0 24‐HR ALL 1ST UCART1 11/7/2015 24 hr 273607.68 2247479.86 1.65916 53 132 0 24‐HR ALL 1ST UCART1 1/31/2016 24 hr 274607.68 2247479.86 1.93546 57.1 146 0 24‐HR ALL 1ST UCART1 12/6/2015 24 hr 275607.68 2247479.86 0.33621 45.4 219 0 24‐HR ALL 1ST UCART1 12/30/2015 24 hr 276607.68 2247479.86 0.03522 33 219 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 277607.68 2247479.86 0.67669 34.8 34.8 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr 278607.68 2247479.86 0.47409 26.5 26.5 0 24‐HR ALL 1ST UCART1 12/21/2015 24 hr

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AQ (HENI) 275607.68 2246479.86 0.25024 35.57 35.57 0 24‐HR ALL 1ST 12/5/2015 24 hr AQ (BHILAD) 279916.74 2244872.28 0.19118 22.92 22.92 0 24‐HR ALL 1ST 12/20/2015 24 hrAQ (PUNAT) 276752.3 2247598.21 0.02859 34.31 84 0 24‐HR ALL 1ST 12/21/2015 24 hrAQ (KANADU) 273710.9 2248366.37 0.38875 31.04 219 0 24‐HR ALL 1ST 11/4/2015 24 hr AQ (SARAI) 271823.72 2244130.7 1.24617 52.28 160 0 24‐HR ALL 1ST 1/2/2016 24 hr AQ (DAHELI) 277578.1 2242240.09 0.24912 30.46 30.46 0 24‐HR ALL 1ST 12/9/2015 24 hr DW1 (PDISCR) 275108.63 2246122.33 1.70501 35.92 35.92 0 24‐HR ALL 1ST 11/21/2015 24 hrDW2 (PDISCR) 274761.3 2245762.66 1.40082 34.43 34.43 0 24‐HR ALL 1ST 11/13/2015 24 hrDW3 (PDISCR) 274413.97 2245402.99 0.99106 35.65 35.65 0 24‐HR ALL 1ST 11/13/2015 24 hrDW4 (PDISCR) 274066.64 2245043.32 0.55155 33.65 33.65 0 24‐HR ALL 1ST 12/23/2015 24 hrDW5 (PDISCR) 273719.31 2244683.65 0.68319 35.15 35.15 0 24‐HR ALL 1ST 12/23/2015 24 hrDW6 (PDISCR) 273371.98 2244323.98 0.76803 39.02 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW7 (PDISCR) 273024.66 2243964.31 0.56238 41.83 160 0 24‐HR ALL 1ST 12/23/2015 24 hrDW8 (PDISCR) 272677.33 2243604.64 0.5713 48.97 160 0 24‐HR ALL 1ST 1/16/2016 24 hr DW9 (PDISCR) 272330 2243244.97 0.56254 51.89 160 0 24‐HR ALL 1ST 1/6/2016 24 hr DW10 (PDISCR) 271982.67 2242885.3 0.37041 41.47 160 0 24‐HR ALL 1ST 12/8/2015 24 hr DW11 (PDISCR) 271635.34 2242525.63 0.29263 30.68 30.68 0 24‐HR ALL 1ST 12/8/2015 24 hr DW12 (PDISCR) 271288.01 2242165.96 0.26093 22.15 22.15 0 24‐HR ALL 1ST 12/8/2015 24 hr DW13 (PDISCR) 270940.68 2241806.29 0.23763 18.65 18.65 0 24‐HR ALL 1ST 12/8/2015 24 hr DW14 (PDISCR) 270593.35 2241446.62 0.21931 24.64 24.64 0 24‐HR ALL 1ST 12/8/2015 24 hr DW15 (PDISCR) 270246.02 2241086.95 0.19817 20.36 20.36 0 24‐HR ALL 1ST 12/8/2015 24 hr DW16 (PDISCR) 269898.69 2240727.28 0.18111 20.69 20.69 0 24‐HR ALL 1ST 12/8/2015 24 hr DW17 (PDISCR) 269551.36 2240367.61 0.1657 17.64 17.64 0 24‐HR ALL 1ST 1/7/2016 24 hr DW18 (PDISCR) 269204.03 2240007.94 0.15586 17.16 17.16 0 24‐HR ALL 1ST 1/7/2016 24 hr DW19 (PDISCR) 268856.71 2239648.27 0.14672 14.69 14.69 0 24‐HR ALL 1ST 1/7/2016 24 hr DW20 (PDISCR) 268509.38 2239288.6 0.1383 15.92 15.92 0 24‐HR ALL 1ST 1/7/2016 24 hr

Page 8

Environmental Testing Method

Annexure- V

ANNEXURE-V: ENVIRONMENTAL TESTING METHOD

Sr.

No. Parameters

Test Method / Standard against which tests

are performed

Range of

testing/ Limits

of detection

Uncertainty of

Measurement

() As per NABL As per MoEF

Ambient Air Quality Monitoring

1. Particulate

Matter PM 10

Gravimetric Method.

IS-5182 Part-23:2006

Gravimetric Method.

IS-5182 Part-23:2006

10 - 1000

g/m3

42 .0 ± 5.1

2. Particulate

Matter PM2.5

Gravimetric Method.

CPCB Manual

Volume – 1, May 2011

Gravimetric Method.

CPCB Manual

Volume – 1, May

2011

4 - 100 g/m3 12.0 ± 7.0

3. Sulphur Dioxide IS-5182(Part-2):2001

Reaffirmed 2006

IS-5182(Part-2):2001

Reaffirmed 2006

4 – 1050 g/m3 33.4 ± 8.0

4. Oxides of

Nitrogen

Jacob & Hochheiser

IS-5182 Part-6:2006

Jacob & Hochheiser

IS-5182 Part-6:2006

6 - 420 g/m3

21.6 ± 5.0

5. Carbon

Monoxide (Co) -- By Using Gas Analyzer -- --

6. Voc --

Adopted from OSHA

& NIOSH (By GLC) -- --

7. Noise Level -- SLM-100 (Instrument) -- --

Stack Emission Monitoring

8. Particulate

Matter

IS 11255( Part 1):1985,

Reaffirmed 2003

IS 11255( Part

1):1985,

Reaffirmed 2003

10 - 500

mg/Nm3

50.0 ± 10.8

9. Sulphur Dioxide IS 11255(Part 2): 1985,

Reaffirmed 2003

IS 11255(Part 2):

1985,

Reaffirmed 2003

4 - 1000

mg/Nm3

16.8 ± 0.70

10. Oxides of

Nitrogen

IS 11255(Part 7):2005 IS 11255(Part 7):2005 5 - 400 mg/Nm3 6.4 ± 2.2

Sr.

No. Parameters

Test Method / Standard against which tests

are performed

Range of

testing/ Limits

of detection

Uncertainty of

Measurement

() As per NABL As per MoEF

Potable and domestic water, Ground water , Surface water ( Rivers, lakes )

Specification: IS 10500:2012

1. Colour

(Pt-Co Scale)

IS 3025(Part 4): 1983,

Reaff. 2006

Visible Comparison

Method

IS 3025(Part 4): 1983,

Reaff. 2006

Visible Comparison

Method

1 – 50 Hazen 10 + 2

2. Odour IS 3025 (Part 5): 1983,

Reaff. 2006

Qualitative Method

IS 3025 (Part 5): 1983,

Reaff. 2006

Qualitative Method

Agreeable/

Not Agreeable

N.A.

3. Turbidity IS 3025

( Part10):1984,

Reaffirmed 2006

Nephelometer

Method

IS 3025

( Part10):1984,

Reaffirmed 2006

Nephelometer

Method

1.0-100 NTU 99.60 ± 0.67

4. pH APHA,22nd Ed., 2012,

4500-H+ B,4-92

IS 3025(Part 11):1983,

Reaff. 2006

By pH Meter

APHA,22nd Ed., 2012,

4500-H+ B,4-92

IS 3025(Part

11):1983, Reaff. 2006

By pH Meter

5 - 12

4.01 ± 0.06

5. Temperature __ IS 3025(Part 9) 1984 -- --

6. Total Hardness

as CaCO3

APHA, 22nd Ed., 2012,

3500 - B, 3-67

EDTA Titrimetric

Method

APHA, 22nd Ed., 2012,

3500 - B, 3-67

EDTA Titrimetric

Method

1 - 500 mg/L

20.80 ± 2.31

7. Total Dissolved

Solid

APHA, 22nd Ed., 2012,

2540 C, 2-65

Gravimetric Method

APHA, 22nd Ed., 2012,

2540 C, 2-65

Gravimetric Method

5 - 1000mg/L 150.80 ± 3.30

8. Calcium as Ca __ APHA, 22nd Ed.,2012,

3500 Ca.B

-- --

9. Magnesium as

Mg

APHA, 22nd Ed.,2012,

3500-Mg, B,3-84

By calculation

APHA, 22nd Ed.,2012,

3500 Mg, B,3-84

By calculation

5 - 500 mg/L

N.A.

10. Total Alkalinity IS 3025(Part 23):

1986,

Reaff. 2009, Amds.2

Titration Method

IS 3025(Part 23):

1986,

Reaff. 2009, Amds.2

Titration Method

0.5 -500 mg /L

51.50 ± 5.40

11. Chloride as Cl- APHA, 22nd Ed.,2012,,

4500-Cl, B,4-72

IS 3025(Part 32):1988,

Reaff. 2009

Argentometric

APHA, 22nd Ed.,2012,,

4500-Cl, B,4-72

IS 3025(Part

32):1988, Reaff. 2009

Argentometric

0.15 - 250

mg/L

9.65 ± 0.82

Method Method

12. Sulphate as SO4-2 IS 3025(Part 24):

1986, Reaff. 2009

IS 3025(Part 24):

1986, Reaff. 2009

1 - 40 mg/L

19.66 ± 0.33

13. Nitrate as NO3 APHA, 22nd Ed.,2012

4500 NO3 -B, 4- 122

UV

Spectrophotometric

Screening Method.

APHA, 22nd Ed.,2012

4500 NO3 -B, 4- 122

UV

Spectrophotometric

Screening Method.

0.01– 10 mg/L

2.01 + 0.59

14. Fluoride as F APHA, 22nd Ed., 2012,

4500-F , D, 4 – 87

(SPADNS

Spectrometer

Method)

APHA, 22nd Ed., 2012,

4500-F , D, 4 – 87

(SPADNS

Spectrometer

Method)

0.15 – 1.4

mg/L

0.75 + 0.27

15. Sodium APHA,22nd Ed.,2012,

3500-Na, B, 3-97

Flame Photometric In

emission mode

Method

APHA,22nd Ed.,2012,

3500-Na, B, 3-97

Flame Photometric In

emission mode

Method

1.0 - 100 mg/L

30.04 ± 0.36

16. Potassium __ APHA 22n

Ed.,2012,3500 K,B

-- --

17. Total Nitrogen __ APHA 22nd Ed.,2012,

4500 NH3 - B

-- --

18. Total

Phosphorous

__ APHA 22nd Ed.,2012,

4500 – P , D

-- --

19. Dissolved

Oxygen

__ IS 3025(Part 38)1989,

(APHA 22nd

Ed.,2012,4500 – O, B)

-- --

20. Bio-Chemical

Oxygen

__ IS 3025(Part 44)1993

Amd .01

-- --

21. Chemical

Oxygen Demand

__ IS 3025(Part 58)2006,

(APHA 22nd

Ed.,2012,5220 –B)

-- --

22. Phenolic

Compound

__ APHA 22nd Ed.,2012,

5530 - C

0.001 --

23. Lead as Pb __ IS 3025(Part 47)1994

Amd.02, (APHA 22nd

Ed.,2012 3111 –B)

0.01 --

24. Arsenic __ APHA 22nd Ed.,2012,

3114 - C

0.01 --

25. Cadmium __ IS 3025(Part41)1992,

(APHA 22nd

0.003 --

Ed.,2012,3111 –B)

26. Total Coliform __ APHA 22nd

Ed.,2012,9222 - B

Absent --

27. E. Coli __ IS : 15185 : 2002 Absent --

Sr.

No.

Parameters Unit Test Method / Standard against which

tests are performed

Soil Quality Testing

1. Bulk Density gm/ml

Soil Chemical Analysis

-By M.L. Jackson

and

Soil & Solid Waste Analysis

-A Laboratory Manual

-By Dr. P.K. Behera

2. Salinity ppt

3. Porosity %

4.

Texture Class

Silt %

Clay %

Sand %

5. Ph( 5% Solution) --

6. Electrical Conductivity µs

7. Cation Exchange Capacity meq/100gm Clay

8. Sodium mg/kg

9. Potassium mg/kg

10. Nitrogen mg/kg

11. Magnesium mg/100 gm

12. Phosphorous mg/100 gm

13. SAR --

14. Water Holding Capacity ml/100 gm

15. Iron as Fe mg/lit.

16. Copper as Cu mg/lit.

17. Zinc as Zn mg/lit.

18. Manganese as Mn mg/lit.

19. Nickel as Ni mg/lit.

Disaster Management Plan

Annexure- VI

DISASTER MANAGEMENT PLAN

ON

MANUFACTURING OF SYNTHETIC ORGANICS CHEMICALS

(Category: 5(f) “B”)

FOR

PROPOSED PROJECT

Of

M/s. HENI DRUGS PRIVATE LIMITED

Located At, Plot No. 1901/1901A, GIDC Estate,

Sarigam – 396155, Dist. - Valsad. (Gujarat) India.

Prepared by,

EIA CONSULTANT ORGANIZATION UNISTAR ENVIRONMENT AND RESEARCH LABS PVT. LTD.VAPI – GUJARAT

INDEX DISASTER MANAGEMENT PLAN 1. Introduction……………………………………………………………………………………………………………………………….. 01

a) Man Made Disasters……….……………………………………………………………………………………………..……. 01 b) Natural Calamities……………………………………………………………………………………………………………….. 01 a) On Site Emergency………………………………………………………………………………………………………..…….. 01 b) Off Site Emergency…………………………………………………………………………………………………….……….. 01

2. Major On-Site Emergency……………………………………………………………………………………………..………… 01 a. Transportation Emergency For Hazardous Chemicals………………………………………………………..……… 02 b. Factors To Be Considered During Evacuation Required Due To Chemical Hazards Spillage………. 02 c. On Site Emergency Management Plan………………………………………………………………………………………. 03

I. Fire – Emergency Control Management……………………………………………………………………………… 03 II. Control Room……………………………………………………………………………………………………………………… 05 III. Emergency Contact List…………………………………………………………………………………………..………….. 06 IV. Assembling Point…………………………………………………………………………………………………………………. 07 V. Warning Signal…………………………………………………………………………………………………………………… 07 VI. Emergency Ending…………………………………………………………………………………………………………….. 07 VII. Emergency Control Committee (ECC)………………………………………………………………………………… 07 VIII. Responsibilities of Persons Involved………………………………………………………………………………….. 08 A. Works Main Controller……………………………………………………………………………………………………….. 08 B. On-Site Incident Controller & Dy. On-Site Incident Controller……………………………………………… 08 C. Communication and Advisory Team…………………………………………………………………………………….. 09 D. Emergency Security Controller……………………………………………………………………………………………. 09 E. Medical Officer………………………………………………………………………………………………………………….. 09 F. Worker……………………………………………………………………………………………………………………………… 09 G. Communication System………………………………………………………………………………………………………. 10 H. Safety Appliances………………………………………………………………………………………………………………… 10 I. Check – Up Schedule………………………………………………………………………………………………………….. 10 J. Training………………………………………………………………………………………………………..……………………. 11 K. Medical Facility…………………………………………………………………………………………..……………………..… 11 L. Mutual Aid…………………………………………………………………………………………..……………………………… 11 M. Mock Drill………………………………………………………………………………………………..………………………..… 11

d. OFF – SITE EMERGENCY MANAGEMENT PLAN…………………………………………………………………… 12 A. Central Control Room (CCR) ……………………………………………………………….…….……………..…………… 12 B. Fire & Rescue Wing…………………………………………………………………………………………………..…………… 12 C. Warning, Evacuation & Traffic Control Wing………………………………………………………………………… 14 D. Actions For Emergencies Involving Road Tankers Carrying Hazardous Chemicals………………… 15 I. Role of Transport Crew………………………………………………………………………………..……………………… 16 II. Role of CCR……………………………………………………………………………………..…………………………..……… 16 III. Methodology………………………………………………………………………………………………………..…………… 16 IV. Evacuation………………………………………………………………………………………………………………………… 16

Annexure I:Evacuation Plan

TABLE

Table-1 List of Safety &Emergency Facilities ……………………………………………………………………………….03 Table-2 List of Fire Extinguisher………………….……………………………………………………………………………….03 Table-3 Location of fire hydrant point with hose box ...................................................................04 Table-4 Emergency responsibilities personals…………………………………………………………………………….06 Table-5 Details of inspection schedule………………………………………………………………………………………..10

DISASTER MANAGEMENT REPORT: M/s. HENI DRUGS PVT. LTD., Proposed Expansion of Synthetic Organic Chemical Manufacturing Unit

1. INTRODUCTION

A disaster is a catastrophic situation in which suddenly, people are plunged into helplessness and suffering and, as a result, need protection, clothing, shelter, medical and social care and other necessities of life. Disasters can be divided into two main groups:

(a) Man Made Disasters Malafide intentions such as sabotage, riots, industrial unrest, air attack etc. resulting into industrial accidents, factory fires, explosions and escape of toxic gases or chemical substances, river pollution, other structural collapses, air, sea, rail and road transport accidents, aircraft crashes, collisions of vehicles carrying inflammable liquids, oil spills at sea etc. will required State/National level resources to combat it. (b) Natural Calamities Disasters resulting from natural phenomena like earthquakes, volcanic eruption, storm, surges, cyclones, tropical storms, floods, landslides, forest fires and massive insect infestation. Also in this group, violent draught which will cause a creeping disaster leading to famine, disease and death must be included. These types of disasters are not under the purview of this plan. Any kind of disaster can result in emergency situation in plant area. Depending on the type & place of the emergency, it can be classified in two categories: (a) On Site Emergency Emergency due to conditions (uncontrolled reaction, small fire, small gas leak, spill, failure of power, water, air, steam, cooling media, scrubbing media etc.) and which can be locally handled by plant personnel alone (without outside help) is not considered as major emergency. Line of actions to tackle such emergencies should be as per the onsite plan. (b) Off Site Emergency A major emergency occurring at work is one that may affect several departments within and / or may cause serious injuries, loss of life, extensive damage to property or serious disruption outside the works. It will require the use of outside resources to handle it effectively. Usually the result of a malfunction or the normal operating procedures, it may also be precipitated by the intervention of an outside agency or natural calamity such as a severe storm, flooding, crashed aircraft or deliberate acts of person or sabotage.

2. MAJOR ON–SITE EMERGENCY

The identification of maximum onsite credible accidents due to Toxic and flammable material may arise from: (1) A slow intermittent release through a leaking relief valve. (2) A fire or mechanical damage is threatened on installation containing toxic and flammable material,

over pressurization or plant failure. (3) Due to spillage of toxic chemicals.

UniStar Environment & Research Labs Pvt. Ltd. (QCI-NABET Accredited)

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(4) A major accident may occur due to sudden release of large quantity of toxic and flammable substances, as it would form large toxic cloud or vapor cloud. Although the probability of such an event occurring is extremely low.

a. TRANSPORTATION EMERGENCY FOR HAZARDOUS CHEMICALS

• The rapid growth of industries in India has boosted the transportation of hazardous chemical by road. This has in turn given birth to transportation emergency. When the carriers of the hazardous substances gets involved in accident it leads to disastrous consequences, maybe due to fire, explosion or toxic spillage resulting in damage of property, environment pollution and sometimes even loss of human life on both the sides of the transportation route. For handling and minimizing such emergency following survey is undertaken.

• The routes of transportation by road for hazardous chemicals are identified and restricted, so that the least populated area is affected during emergency.

• Population survey on both sides of the proposed transportation routes up to 500mm is undertaken so that the approximate number of people likely to be affected can be identified beforehand. Accordingly necessary evacuation and medical preparedness can be planned during the time of emergency.

b. FACTORS TO BE CONSIDERED DURING EVACUATION REQUIRED DUE TO CHEMICAL HAZARDS SPILLAGE

(i) The Dangerous Goods • Degree of health hazard • Amount involved. • Containment /control of release. • Rate of vapor movement.

(ii) The Population Threatened • Location • Number of people • Time to evacuate or protect in place • Ability to control evacuation or protection in place • Building types and availability • Special institutions or populations e.g. nursing homes, hospitals, etc.

(iii) Weather conditions • Effect on vapor and cloud movement • Potential for change • Effect on evacuation or protection in-place.


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c. ON SITE EMERGENCY MANAGEMENT PLAN

This emergency management plan specially deals with “On-site emergency” i.e. with respect to accidents that may take place in the industry and their effects are confined to the factory premises, involving only the people working in the factory.

i. Fire – Emergency Control Management

• Any person who notices fire will immediately inform through phone or massager to: - Main gate - Concerned supervisor/shift incharge - HOD (Security and firefighting)

• Concerned supervisor will switch off electricity near the place of fire. • Use suitable firefighting equipment placed at various locations. Fire extinguishers will be provided

in all area; information of the fire extinguishers will be shown on plant layout drawing and provided to all department & concern personal. Following are the details of the fire extinguishers provided within premises.

Table 1: List of Safety &Emergency Facilities Sr.no.

Particular of Equipment Requirement

1 DCP powder (50% of fire extinguishers ) 17 2 CO2 Cartridges ( 50% of fire extinguishers ) 7 3 Sand scoops 8 4 Safety helmets 20 5 Stretchers 1 6 First aid box with anti-snake serum& Antidotes 3 7 Rubber hand gloves 20 8 Explosive meter 0 9 Fire entry suit w/o breathing apparatus 0

10 Resuscitator 0 11 Electric siren with 3 km range 0 12 Water gel blandest 0 13 Red/green flags for fire drill 0 14 Safety Goggles 20 15 Ambulance 0 16 Safety Shoes 20 17 Mention if any other

Table 2: List of Fire Extinguisher Sr. No. Area Type of Extinguisher Nos Capacity

1 Manufacturing & Utility Areas For ex. CO2, DCP/Foam 12 2 to 4 kgs 2 Laboratory DCP 1 2 to 4 kgs 3 R.M. Storage &Tank Area DCP/Foam 4 2 to 4 kgs 4 Finish Goods Area DCP 4 2 to 4 kgs 5 Office CO2 2 1 to 2 kgs


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6 Security Office CO2/DCP 4 2 to 4 kgs 7 Spare Foam/DCP 4 2 to 4 kgs 8 Mention if any other - - -

Table 3: Location of fire hydrant point with hose box

Sr. No. Area / Plant Nos. Of Hydrant point with hose

box 1 Plant Areas 6 2 Ware house 1 3 R.M. Storage and Tank area 1 4 Utility area 0 5 Administrative Building 0 6 Security Area 1 7 Laboratory Area 0 Mention if any other

• Use fire hydrant provided in the plant properly as per suitability under guidance & supervision of

site in charge. Following are the details of the fire hydrant points with Hose Box provided within premises.

• Main gate will send ambulance to the accident site and inform Chief Medical Officer. • Security and firefighting personnel will rush to the site along with necessary equipment and cordon

off the area. They will not allow unauthorized persons to enter in the area of fire. • Security and firefighting personnel and other personnel will start using suitable firefighting

equipment to extinguish fire. • HOD Utility will ensure smooth supply of water. • HOD will arrange to remove any stored material that is likely to come in contact with fire and may

catch fire. • HOD will arrange to dispose burnt material as waste as per waste disposal of that department and

take appropriate action for mitigation of environmental impacts. Emergency Control Procedure for Hazardous Chemicals

• In case of any major incident in chemical storage &/or transfer/handling system, immediately inform through phone or messenger to: Main gate Concerned supervisor / shift in charge HOD ( Security & Fire Fighting)

• Main gate will inform ambulance to send at the accident site and inform to Medical Officer. • Security and firefighting personnel will rush to the site along with necessary equipment and cordon

off the area. They will not allow unauthorized persons too near to the accident site.


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• The emergency management team will follow the methods established in line with the guidelines of “Chemical Emergency Response Guide” as prepared separately for all chemicals.

• If any person is injured or affected in incident, provide first aid or shift him to dispensary, if required.

• If there is fire following leak/spill, follow procedure for mitigation of fire. • If there is spillage of hazardous chemical following fire &/or dispersion, HOD arrange to collect the

material, clean the area and dispose it accordingly after treatment as per the methods established in line with the guidelines of “Chemical Emergency Response Guide” as prepared separately for all chemicals.

• HOD will arrange to transfer spilled material and take appropriate action for mitigation of environmental Impacts as per the waste disposal plan and regulatory guidelines.

• Effluent treatment plant will take necessary action to treat the effluent arising out of the emergency control /management activities effluent.

ii. Control Room

The security office, at main gate, will be the control room that is manned 24 hours. The control room will be headed by Manager- Security, assisted by HOD (Personnel) and Safety Officer. The following facilities are available in the control room:

• Layout of the plant • Emergency Contact List • Maximum number of people working at a time and assembly points • Population around the plant • Internal and external telephones with telephone directory • Public address system • Torch lights • List of dispensaries and registered medical practitioners around the plant • Area map of surrounding villages • Nominal roll of employees • Note pads and pencils to record message received and instruction to be passed through runners • The methods established in line with the guidelines of “Chemical Emergency Response Guide” • “Chemical Emergency Response Guide” • A copy of Emergency Plan • List of emergency control committee, emergency crew, medical staff, transportation staff, and

security and firefighting staff • First aid box, jiggery, and peppermint • Sitting arrangement


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iii. Emergency Contact List

• During emergency, any person facing incident or any person aware of incident or any person seeking information for emergency contact details will use the following list.

Table 4: Emergency responsibilities personals: S.

No. Name / Designation Contact Nos.

1 Mr. Kapil Girotra Director

Direct Line 0260-2780432-25 Intercom Home Mobile

2 Mr. vithalbhai pawar (Unit Head)


3 Mr. Vithal pawar (Manager – Production)


4 Mr. prasatbhai (Manager-Maintenance)


5 Mr. Prasantbhai (EHS-Manager)


6 Mr. (EXECUTIVE-Adm./P&A/HR)

Direct Line Intercom Home Mobile

7 Mr. (Incharge QC)


8 Mr. (Incharge Safety & Security)


10 Mr. (Security In-charge)

Direct Line 0260-2780432-21

Intercom

Home Mobile

11 Local Crisis Control Room, GIDCSarigam

0260- 278139


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S. No. Name / Designation Contact Nos.

12 Fire Services, 0260-2780222

Common Fire Service Contact, Hot Dial

101

13 Police Stations/control room: Sarigam Umergaon Bhilad Daman Silvassa Valsad

0260 - 2780933 0260 - 2562333/2561255 0260 – 2784033 0260-2254100/2254999 0260- 2642130/2642002 02632-242900/253333

Police Control Room, Hot Dial 100

14

Collector Office Mamlatdar, Umergam Mamlatdar, Disaster, Valsad

02632 - 243417/253613 0260 – 2562089 02632-243238/244274/244279

15 GPCB–VAPI 2432089/2426207

16 GSPC Local Emergency Contact 0260-6452000

17 Primary Health Centre, Sarigam 0260-2562445

18 Haria Hospital, Vapi 0260-2400053/2430206

19 CHC And Government Refferal Hospital, Bhilad

0260-2374329, 2375519

20 Ambulance & Emergency, Hot Dial 108

21

Blood Bank Nukem Blood Bank (Haria) Lions Blood Bank

0260 - 2430654,2400053 0260- 2434600,2434601

iv. Assembling Point


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During emergency, one emergency assembling point is provided near main gate area. Main gate will be the assembly points depending upon the wind direction and location of the person with respect to incident area. The person will move opposite to wind direction (facing direction from which wind is blowing) and away from the source of chemical leakage. When possible and space is available, person will move into left & right direction of the wind direction and finally will reach to the assembly point. Wind direction may be known by seeing direction of windsocks located at different points in the company and direction of stack smoke. Name of neighbor industries:

1. HIGH PURITY LABORATORY CHEMICALS PVT LTD 2. HARDCASTLE PETROFER PVT LTD 3. SUPERSEAL CHEMICALS ( I ) PVT LTD 4. MERIT ORGANICS PVT LTD. 5. COROMANDEL INTERNATIONAL LTD.

v. Warning Signal

In case of emergency, people will be informed by raising siren. Manager Security/Manager P&A are authorized to raise siren. Siren will be blown intermittently for 5 minutes and will be treated as declaration of major emergency. Siren will be located at turbine house of power block.

vi. Emergency Ending

The emergency will be declared ended when the source of gas emission has been effectively isolated and gas clouds dispersed. This will be done by on – site incident controller. Siren will be blown intermittently for 2 minutes to declare emergency end.

vii. Emergency Control Committee (ECC)

The emergency control committee will be comprising of the following members. • Managing Director/Units Head - Main Controller • General Manager – On-site Incident Controller(Leader) • Production Manager – Dy. On-site Incident (Jn. Leader) • Manager (EHS)- On-Site Instructor • Maintenance Manager • Manager (P&A, Admin) • HOD (Laboratory) • In-charge/Manager (Godown) • Manager (Commercial) • In-charge/Manager (Security) • Safety Officer


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Figure 1.1: Schematic representation of EMC

viii. Responsibilities of Persons Involved A. Works Main Controller

Either or Both of Managing Director & Unit Head will be works main controller. He/they will take care of on – site emergency plan. As soon as he/they is/are informed of emergency, he / they will: • Assume responsibilities for overall main control. • Ensure that members mentioned called in. • Maintain a speculative continuous review of possible development and assess these to

determine most probable cause of events. • Arrange to maintain chronological record of emergency. • Issue authorized statements to news media and inform head office. • Inform outside emergency services including fire, police, hospitals, District Magistrate.

B. On-Site Incident Controller & Dy. On-Site Incident Controller Either of General Manager or Manager Production will the on –site incident controller. When General Manager is assigned duty of On-site Incident Controller the Manager Production will be acting as Dy. On-site Incident controller to as per direction of General Manager. In other case, when General Manager is not available, Dy. On-Site Incident controller will act as On-site Incident Controller. As soon as he/they is/are informed of emergency he/they will proceed to the site. On arrival he/they will: • Assess the scale of emergency and decide if a major emergency exists or likely to exist and

declare it • Direct all operation for controlling and stopping chemical leakage with the following priorities:

- Secure safety of personnel


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- Minimum damage to plant and machinery • Direct rescue operation • Ensure that affected area is searched for causalities • Ensure that all non-essential workers in affected area leave the place (direct them to go to the

assembly point as per wind direction) • Report developments to works main controller • Keep record to preserve evidences to facilitate any subsequent enquiry

C. Communication and Advisory Team This team will consist of manager/head of various departments of the company.

D. Emergency Security Controller He will be the senior most security person located at main gate office. He will take care of security of the plant and also guide outside government agencies.

E. Medical Officer Medical officer will be a doctor / trained compounder at occupational health center / dispensary of plant / first aid center.

F. Worker • Workers /employee of A/B/C shift having duty in following area/department will not leave

their place of work without instruction by On-site Incident Controller &/or Dy. On-site Incident Controller &/or HOD of respective area/department: - Boiler operation - Tank Farm Area - Water supply - Electrical Dept. - Logistic/transportation

• Persons of any department instructed specifically not to leave the plant by shift in-charge/ shift supervisor

• Shift workers will see that leakage in any tank is contained and eliminated under guidance of their supervisor/shift in-charge

• Shift workers are strictly subjected to follow the manual of Chemicals while working in the area having hazardous chemicals. All workers will work with hazardous chemicals only under guidance /supervision of their supervisor / shift in-charge

• Shift workers (Water Supply) will ensure water supply to colony and plant. In no case water supply to the colony will be cut off.

• Shift workers (Electrical) will ensure power to water supply, colony, and plant. In no case power is to be switched off. They will also ensure cut-off of power in the area where power supply required to be stopped.

• Boiler attendants and operators will ensure that their plants are stopped in orderly manner without any damage.

• In-charge of transportation will ensure that their vehicles are parked in proper area to avoid


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blockage on road and all vehicles are in ready condition for evacuation operations in case of evacuation is required.

• Other shift workers specifically instructed not to leave the plant, will perform the following function: - Act as extra first aiders to deal with casualties - Transport equipment, if any, to the incident - Remove vehicles away from the risk areas - Act as runners in case of communication difficulties - Any other work directed by senior person present at that location

• All other workers, except those mentioned above, will leave their work place after stopping their plant properly to avoid damage.

• After completing the above-mentioned/assigned works, all workers will leave their place immediately.

G. Communication System

Following communication system will be followed: • Control room and place of incidence: Telephone/Mobile/Messenger/Internal

Network/Internet • Between two control teams: Telephone/Messenger/Walky-talky/Mobile/Internal Network • For general communication is all area: Mike/Speaker equipped with microphone further,

public address system is provided at control room. H. Safety Appliances

All safety appliances as required to combat the emergency as suggested in “Chemical Safety measures/MSDS” will be made available in plant. All plant area will have suitable safety equipment like; fire extinguisher, self-contained breather, mask, goggles, safety suit, hydrant etc. as required.

I. Check – Up Schedule For handling of hazardous materials, standard procedures shall be followed. Further, regular check-up shall be done to ensure safety. Guidelines for such check-up are given below:

Table 5: Details of Inspection Schedule Particular Frequency Responsibility Leakage in Hazardous Chemicals Tanks/Drum/Container/Pipelines

Daily Manager (Production)

Temperature, Pressure & Groundings Daily Manager (Production) Storage & handling of materials as per standard procedure

Daily Manager (Production & EHS)

Pump, Motors & Valves for operation Weekly Manager (Maintenance) Availability & Conditions and use of Safety appliances

Weekly Manager (EHS&/or HR)

First aid box, peppermint, antidotes, vaccines and medicines

Weekly Manager (Production&/or HR)

Fitting and fixtures Monthly Manager (Maintenance)


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Recalibration of pressure gauge & flow meters

Monthly HOD (Instrumentation)

Siren Daily HOD (Electrical) Mock drill for Chemical leakage & Fire Half yearly Manager (Production) Medical check – up Half yearly Manager (HR/P&A) Testing of hoist, ropes, and sling Yearly Manager (Maintenance) Pipeline and fitting replacement Once in 4 yrs. Manager (Maintenance)

J. Training

To educate employees, their families, and inhabitants in surrounding villages regarding precautions to be adopted and information system in case of hazardous chemical leak and also to train a group of employees in methods and procedures to prevent and/or to contain such leak is highly essential and is provided as under: • Training and holding regular mock drills in dealing with hazardous chemical leak to employees

working in hazardous chemical handling area, production plant & other areas. • Training and holding mock drill in dealing with hazardous chemical leak and familiarization with

terrain to fire and security staff. • General safety instructions to protect individual from effects of chemicals are also propagated

through safety exhibitions. Further, these instructions are displayed and distributed in English, Hindi, and Gujarati.

K. Medical Facility The company shall have occupational health center/ dispensary for medical treatment. A full time/contracted MBBS, MD doctor shall be in charge of the center. Further, many hospitals are located nearby area / villages. To provide first aid to the affected person first aid box will be provided in the company. First aid box will be regularly checked.

L. Mutual Aid While necessary facilities shall be made available and shall be updated from time to time, sometimes, it may be necessary to seek external assistance; it may be from the neighboring factories or from the State Government as the case may be. Upon inception of operation of the company following company of GIDC sarigam will be contacted to establish the mutual facilities for emergency management. 1. HIGH PURITY LABORATORY CHEMICALS PVT LTD 2. HARDCASTLE PETROFER PVT LTD 3. SUPERSEAL CHEMICALS ( I ) PVT LTD 4. MERIT ORGANICS PVT LTD. 5. COROMANDEL INTERNATIONAL LTD.

M. Mock Drill In spite of detailed training, it may be necessary to try out whether, the Onsite Emergency Plan work out and will there be any difficulties in execution of such plan. In order to evaluate the plan and see whether the plan meets the objectives of the Onsite Emergency Plan, occasional mock drills are contemplated. Before undertaking the drill, it would be very much necessary to give


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adequate training to all staff members and also information about possible mock drill. After few pre-informed mock drills, few UN-informed mock drills would be taken. All this is to familiarize the employees with the concept and procedures and to see their response. These scheduled and unscheduled mock drills would be conducted during shift change, public holidays, in night shift etc. To improve preparedness once in 6 months and performance is evaluated.

d. OFF – SITE EMERGENCY MANAGEMENT PLAN The off-site emergency plan prepared herein will deal with those incidents, identified in the on-site plan, which have the potential to affect adversely the persons or the environment outside the boundary of the premises. Whenever such an emergency occurs, there is a great need to control and isolate the danger, and to minimize the adverse effect to the greatest extent possible. This plan has been drawn up with a view to mobilize resources and integrate with State Contingency Plan for an effective system of command and control in combating the emergency. The off-site plan is the tool for co-ordination of existing services and their readiness, as far as possible, for the hazards and problems, which may arise in an incident. The information for the off-site emergency plan such as site Data, Toxic Cloud Dispersion distances, Role of Factory Management, External Support Services, Transportation Emergencies etc. is furnished.

Thus in brief the two main purposes of the off-site emergency plan are: • To provide the local/district authorities, Police, Fire Brigade, Doctors, surrounding industries and

public, the basic information of risk assessment and to appraise them of the consequences and the protection/prevention measures and control plans and to seek their help to communicate with the public in case of a major emergency.

• To assist the State Authorities (GSDMA, Collectors etc.) for preparing the off-site emergency (Contingent) plan for the district or particular area and to organize rehearsal from time to and initiate corrective actions based on the lessons learnt.

A. Central Control Room (CCR) The central control room is the place under the control of chairman of local crisis plan (LCP) committee, where the operations to handle the emergency are directed and co-ordinated. It is the Centre of Resources Mobilisation, Information & Media Communication.

B. Fire & Rescue Wing The control of fire is normally the role of the fire commandant, till the controller of team of local disaster management authority come on site. He may also have a similar role for other type of incident like explosions, toxic release and collapse of structure where rescue work is to be carried out in scientific and systematic way. He has to ensure mobilization of all the fire services, and other requirements to achieve the target. He will liaise with other coordinator and feed the information regarding incident to the scene of fire or to the site. PHASE 1: During Normal Circumstances Fire & Rescue Wing Should Carry Out and Get Prepared During Normal Period 1. Identify hazard potential areas. 2. Knowledge of approach roads & escape routes.


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3. Provision adequate water supply and knowledge of other sources of water supply. 4. Arrangement of adequate type of firefighting equipment. 5. Provision of well-trained manpower. 6. Arrangement for pulling out manpower and resources from various units, without loss of time. 7. Provisions of required quantity of fire extinguishing chemicals & their easy procurements, also

with mutual aid system. 8. Proper & efficient communication system, preferably wireless, on single channel. 9. Adequacy of specialized rescue team, with specific equipment. 10. Maintaining the standard firefighting equipment and store in working condition to meet call at

any time. 11. Operational uniformity- fire response plan. 12. Knowledge of chemicals and their properties and types of fire extinguishing media to be sued. 13. To arrange the training for fire crews and rescue team for evacuating purpose. 14. Incident involving chemical emergency/ toxic gas release, situation shall be handled by

wearing self-contained breathing apparatus, along with protective clothing. 15. Fire commander shall keep ready a special jacket, to wear during emergency for identification.

Proper co-ordination is required with police for the quick movement of fire fighting vehicles. 16. To know about the arrangement to keep open railway level crossing for quick movement of

fire fighting vehicles I required with railway authority. PHASE 2: During Emergency 1. For identification of fire-commander shall wear a special jackets or identification. 2. Immediately after receiving the message from Local Control Room (LCR), the Fire Commandant

shall activate/mobilize the crew to order from nearby Fire Station & rush to the site under intimation to LCR.

3. The fire commandant, before ordering, will ensure the type of fire-extinguishing media required and approximate quality on getting information about the scene of fire or the units.

4. At the site of incident, the Fife Commandant will thoroughly observe and inspect and survey the site for the use of fire media, and will start functioning accordingly, till the emergency is controlled in all respect, with constant touch with LCR, giving the details and adopted controlling procedures.

5. Fire commandant will act as Incident controller at site. All the agencies shall report to him at site.

6. Further, in case of more help required, he will report to LCR accordingly with specific and clear instructions for such help.

7. For the suspect trapped personnel, in case of toxic gas leakage and major fire, rescue operation will be carried out as instructed by LCR on the advice of experts using necessary respiratory protection system.

PHASE 3: After Emergency


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1. Incident controller will give the details about the incident to LCR also, for further actions, if required.

2. After “ALL OK SIREN” the necessary precautionary measures will be put in practice. 3. Work of removal of debris, removal of trapped persons or removal of dead bodies or other

work as per scenarios & instructions will be carried out. 4. Incident Controller will assess the total damage and will give clear report about the scene to

the chairman of LCG. 5. Incident controller will assess the adequacy of the work carried out and lacuna in the actions

and find out the improvement to be required. C. Warning, Evacuation & Traffic Control Wing

Role: Formal duties of the Police Authority during emergency include protecting life and property and

controlling traffic movement. Further, police have to control and evacuate unnecessary public, to cordon off area of incident and ensure free movement of vehicles involved in relief operations.

Functions: 1. Control and regulations of traffic within the area of incident. 2. Assist the fire-fighting wing by cordoning off the affected area and help the fire-fighting wing

by supplementing fire-fighting personnel to the extent possible. 3. Assist the medical & evacuation personnel to work without any hindrance and help the

medical department in evacuating casualties. 4. Prevent unauthorized entry into the affected area. 5. To control general law & order situation. During Normal Circumstances: 1. To develop control point and communication system. 2. To plan clear chain of command and control for controlling traffic at accident site. 3. To decide assembly point, shelter points etc. keeping in view the wind direction. 4. To arrange necessary equipment for warning the population. 5. To prepare procedure to regular traffic and diversion of traffic on approach road to accident

prone industrial pockets. 6. To keep co-operation with all emergency services and Control Room. 7. To arrange training for police staff. 8. To gain knowledge of risk hazards and identify accident-prone areas. 9. To decide strategy to pull out resources. 10. To issue passes to persons expected on duty, transport services and others. 11. To communicate about transfer of officer, charge in address with telephone number to the LCG

for updating the information. 12. To decide procedure to maintain records.


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13. To lay down the scheme of wireless network for smooth flow of information to various agencies for containing the emergency.

During Emergency: 1. On getting information about the emergency, from incident place or from the chairman of LCG

and DySP, start functioning of control room at the incident place. 2. Arrangement should be made to maintain law and order in strict manner at the incident place

and nearby. 3. Arrangement to control unwanted traffic and to divert unwanted traffic via safe route. 4. To post senior police officers near the mishap site. 5. Immediate and continuous announcement to make awareness about emergency among

surrounding population. 6. Cordon the area so that area will not be crowded or blocked by unwanted people. 7. To keep the road clear and to see smooth flow of traffic. 8. To work in consultation with CCR and report the details of real position of each place. 9. To keep and carry out evacuation and remove trapped persons. Moreover, to ensure

protection of property in evacuated areas. 10. To divert the person to first air post, casualty receptions center and base hospital according to

the situation. 11. To ensure that there is no interruption in the performance of tasks allotted to other

emergency services. 12. Communicate the surrounding public instructing them to leave the area and move to the

shelters and other safe place as decided, in case of release of toxic gas, the clear instruction should be communicated by wireless set/walkie-talkie through mobile vehicles, who should also wear the protective equipment like self -breathing apparatus.

After Emergency: 1. The evacuated areas (industrial and residential) should be securely protected till the

rehabilitation is completed. 2. The place of incident should be preserved from evidence and theft point of view. 3. After getting clearance from LCR, traffic should be resorted in the control way. The report of activities carried out during and after the emergency should be submitted to the

Chairman of LCG. D. Actions For Emergencies Involving Road Tankers Carrying Hazardous Chemicals

In recent years, India has witnessed rapid growth in transportation of hazardous chemicals by road. Major road accidents have clearly demonstrated that hazardous chemical carries, when involved in accidents, can cause disastrous consequences like fire, explosion & spillage resulting in loss of life and property besides environmental pollution. Such accidents demand immediate availability of essential information to take appropriate counter measures.


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The products of chemical industry vary enormously in their types, property and degree of hazard, ranging from explosives to plaster board. These are transported as solids, liquids in a wide range of temperatures and pressures. Realizing the dangers, the new Motor vehicles Act 1988 has been introduced in India by imposing permit conditions for vehicles carrying hazardous substances. Under this new act, every motor vehicle carrying hazardous substances should comply with certain regulations.

(i) Role of Transport Crew 1. Motor vehicle carrying hazardous substance should have the emergency information panel which

provides details in the event of emergency. It indicates the Correct technical name of the substance being transported, it’s UN – Number, Hazchem Code and UN Hazard class label. The panel also provides for contact telephone number in an emergency, as also specialist advice.

2. The driver of the vehicles should possess related Tremcard from the respective suppliers and to be kept on the vehicles.

3. To maintain the vehicles, accessories, protective clothing and other equipment in good conditions 4. In case of mishap, the driver should be reported, immediately, to the nearest police station. 5. At the time of mishap, the helper/ cleaner/ driver who-so-ever remain present should handover

‘Tremcard’ or written information about the contained chemicals to the emergency services. (ii) Role of CCR On the receipt of an incident/mishap report, the Central Control Room will ensure that the emergency services have been summoned through Fire Officer of the company, till the fire controller of LCG comes at site and will obtain the specialist advice & inform the expert to remain on telephone, if any assistance is needed. A manufacturer’s/ trader’s/ supplier’s specialist advice should normally be sought if deemed necessary after the situation has been assessed by the Emergency Services. This procedure may, however, be varied according to the situation and advice by experts. (iii) Methodology Policy based on the knowledge of immediate danger area does the action for initial cordoning. (iv) Evacuation 1. Determination the extent of evacuation required in consultation with the emergency commander. 2. Residents should be advised to travel slowly and cautiously and not to burden themselves with

unnecessary baggage. 3. Ensure that buses/trucks/vehicles are properly lined up at various picks up points. Responsible

officer should be posted at these points to supervise loading and dispatch of buses/vehicles. 4. Ensure that drivers of buses/vehicles/trucks are given clear instruction about route and their

destination. 5. Make proper security arrangement to look after houses and property in their absence, in other

words, chances of theft etc. should be minimized during the period when the residents are away. 6. Get in touch with Div. Manager (Railway) & / or Local State Transport Manager to arrange the

evacuation by railway or bus if required.


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7. Ensure that battery/diesel operated floodlights are ready to be made functional in case there should be need for the same.

8. Decide in consultation with emergency commander for return of residents. Register should be maintained giving evacuation and other details with time. If evacuation is required, it is carried out as guided in the “Chemical Emergency Response Guidelines” table of isolation and protective action distances. Before Evacuation the following factors are also to be considered. The Dangerous Goods • Degree of health hazard • Amount involved • Containment /control of release • Rate of vapor movement The Population Threatened • Location • Number of people • Time to evacuate or protect in place • Ability to control evacuation or protection in place • Building types and availability • Special institutions or populations e.g. nursing homes, hospitals, etc. Weather conditions • Effect on vapor and cloud movement • Potential for change • Effect on evacuation or protection in-place.


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A),ERPG GUIDE

Chemical Safety plans

Annexure- VII

1. ACETIC ACID

GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE

POTENTIAL HAZARDS FIRE OR EXPLOSION · Flammable/combustible material. · May be ignited by heat, sparks or flames. · Vapors may form explosive mixtures with air. · Vapors may travel to source of ignition and flash back. · Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). · Vapor explosion hazard indoors, outdoors or in sewers. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Runoff to sewer may create fire or explosion hazard. · Containers may explode when heated. · Many liquids are lighter than water.

HEALTH · May cause toxic effects if inhaled or ingested/swallowed. · Contact with substance may cause severe burns to skin and eyes. · Fire will produce irritating, corrosive and/or toxic gases. · Vapors may cause dizziness or suffocation. · Runoff from fire control or dilution water may cause pollution.

PUBLIC SAFETY · CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. · As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. · Keep unauthorized personnel away. · Stay upwind. · Keep out of low areas. · Ventilate closed spaces before entering.

PROTECTIVE CLOTHING · Wear positive pressure self-contained breathing apparatus (SCBA). · Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. · Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

EVACUATION Spill · See Table 1 - Initial Isolation and Protective Action Distances for highlighted materials. For non-highlighted materials, increase, in the downwind direction, as necessary, the isolation distance shown under "PUBLIC SAFETY". Fire · If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

EMERGENCY RESPONSE Fire · Some of these materials may react violently with water. Small Fire · Dry chemical, CO2, water spray or alcohol-resistant foam. Large Fire · Water spray, fog or alcohol-resistant foam. · Move containers from fire area if you can do it without risk. · Dike fire-control water for later disposal; do not scatter the material. · Do not get water inside containers. Fire involving Tanks or Car/Trailer Loads · Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. · Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. · ALWAYS stay away from tanks engulfed in fire. · For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. SPILL OR LEAK · Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. · ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). · All equipment used when handling the product must be grounded. · Do not touch or walk through spilled material. · Stop leak if you can do it without risk. · Prevent entry into waterways, sewers, basements or confined areas. · A vapor suppressing foam may be used to reduce vapors. · Absorb with earth, sand or other non-combustible material and transfer to containers (except for Hydrazine). · Use clean non-sparking tools to collect absorbed material. Large Spill · Dike far ahead of liquid spill for later disposal. · Water spray may reduce vapor; but may not prevent ignition in closed spaces.

FIRST AID · Move victim to fresh air. · Call 911 or emergency medical service. · Give artificial respiration if victim is not breathing. · Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. · Administer oxygen if breathing is difficult. · Remove and isolate contaminated clothing and shoes. · In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. · In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. · Keep victim warm and quiet. · Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. · Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

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ERG2012

GUIDE 153 SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)

POTENTIAL HAZARDS HEALTH · TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. · Contact with molten substance may cause severe burns to skin and eyes. · Avoid any skin contact. · Effects of contact or inhalation may be delayed. · Fire may produce irritating, corrosive and/or toxic gases. · Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

FIRE OR EXPLOSION · Combustible material: may burn but does not ignite readily. · When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Contact with metals may evolve flammable hydrogen gas. · Containers may explode when heated. · Runoff may pollute waterways. · Substance may be transported in a molten form.

PUBLIC SAFETY · CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. · As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for

liquids and at least 25 meters (75 feet) for solids. · Keep unauthorized personnel away. · Stay upwind. · Keep out of low areas. · Ventilate enclosed areas.



EMERGENCY RESPONSE Fire Small Fire · Dry chemical, CO2 or water spray. Large Fire · Dry chemical, CO2, alcohol-resistant foam or water spray. · Move containers from fire area if you can do it without risk. · Dike fire-control water for later disposal; do not scatter the material. Fire involving Tanks or Car/Trailer Loads · Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. · Do not get water inside containers. · Cool containers with flooding quantities of water until well after fire is out. · Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. · ALWAYS stay away from tanks engulfed in fire. SPILL OR LEAK · ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). · Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. · Stop leak if you can do it without risk. · Prevent entry into waterways, sewers, basements or confined areas. · Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. · Do not get water inside containers.

FIRST AID · Move victim to fresh air. · Call 911 or emergency medical service. · Give artificial respiration if victim is not breathing. · Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. · Administer oxygen if breathing is difficult. · Remove and isolate contaminated clothing and shoes. · In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. · For minor skin contact, avoid spreading material on unaffected skin. · Keep victim warm and quiet. · Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. · Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

2. Bromine

GUIDE 154 SUBSTANCES - TOXIC and/or CORROSIVE (Non-Combustible)

POTENTIAL HAZARDS HEALTH · TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. · Contact with molten substance may cause severe burns to skin and eyes. · Avoid any skin contact. · Effects of contact or inhalation may be delayed. · Fire may produce irritating, corrosive and/or toxic gases. · Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

FIRE OR EXPLOSION · Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. · Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). · Contact with metals may evolve flammable hydrogen gas. · Containers may explode when heated. · For UN3171, if Lithium ion batteries are involved, also consult GUIDE 147.

PUBLIC SAFETY · CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. · As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. · Keep unauthorized personnel away. · Stay upwind. · Keep out of low areas. · Ventilate enclosed areas.



EMERGENCY RESPONSE Fire Small Fire · Dry chemical, CO2 or water spray. Large Fire · Dry chemical, CO2, alcohol-resistant foam or water spray. · Move containers from fire area if you can do it without risk. · Dike fire-control water for later disposal; do not scatter the material. Fire involving Tanks or Car/Trailer Loads · Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. · Do not get water inside containers. · Cool containers with flooding quantities of water until well after fire is out. · Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. · ALWAYS stay away from tanks engulfed in fire. SPILL OR LEAK · ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). · Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk. · Prevent entry into waterways, sewers, basements or confined areas. · Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. · Do not get water inside containers.

FIRST AID · Move victim to fresh air. · Call 911 or emergency medical service. · Give artificial respiration if victim is not breathing. · Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. · Administer oxygen if breathing is difficult. · Remove and isolate contaminated clothing and shoes. · In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. · For minor skin contact, avoid spreading material on unaffected skin. · Keep victim warm and quiet. · Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. · Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves

3. Ethanol

GUIDE 127 FLAMMABLE LIQUIDS (Polar / Water-Miscible)

POTENTIAL HAZARDS FIRE OR EXPLOSION · HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. · Vapors may form explosive mixtures with air. · Vapors may travel to source of ignition and flash back. · Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). · Vapor explosion hazard indoors, outdoors or in sewers. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Runoff to sewer may create fire or explosion hazard. · Containers may explode when heated. · Many liquids are lighter than water.

HEALTH · Inhalation or contact with material may irritate or burn skin and eyes. · Fire may produce irritating, corrosive and/or toxic gases. · Vapors may cause dizziness or suffocation. · Runoff from fire control may cause pollution.


PROTECTIVE CLOTHING · Wear positive pressure self-contained breathing apparatus (SCBA). · Structural firefighters' protective clothing will only provide limited protection.

EVACUATION Large Spill · Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire

· If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

EMERGENCY RESPONSE Fire CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small Fire · Dry chemical, CO2, water spray or alcohol-resistant foam. Large Fire · Water spray, fog or alcohol-resistant foam. · Do not use straight streams. · Move containers from fire area if you can do it without risk. Fire involving Tanks or Car/Trailer Loads · Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. · Cool containers with flooding quantities of water until well after fire is out. · Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. · ALWAYS stay away from tanks engulfed in fire. · For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. SPILL OR LEAK · ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). · All equipment used when handling the product must be grounded. · Do not touch or walk through spilled material. · Stop leak if you can do it without risk. · Prevent entry into waterways, sewers, basements or confined areas. · A vapor suppressing foam may be used to reduce vapors. · Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. · Use clean non-sparking tools to collect absorbed material. Large Spill · Dike far ahead of liquid spill for later disposal. · Water spray may reduce vapor; but may not prevent ignition in closed spaces.

FIRST AID · Move victim to fresh air. · Call 911 or emergency medical service. · Give artificial respiration if victim is not breathing. · Administer oxygen if breathing is difficult. · Remove and isolate contaminated clothing and shoes. · In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. · Wash skin with soap and water. · In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. · Keep victim warm and quiet. · Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

4. Isopropanol

GUIDE 129 FLAMMABLE LIQUIDS (Polar / Water-Miscible / Noxious)

POTENTIAL HAZARDS FIRE OR EXPLOSION · HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. · Vapors may form explosive mixtures with air. · Vapors may travel to source of ignition and flash back. · Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks).

· Vapor explosion hazard indoors, outdoors or in sewers. · Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. · Runoff to sewer may create fire or explosion hazard. · Containers may explode when heated. · Many liquids are lighter than water.

HEALTH · May cause toxic effects if inhaled or absorbed through skin. · Inhalation or contact with material may irritate or burn skin and eyes. · Fire will produce irritating, corrosive and/or toxic gases. · Vapors may cause dizziness or suffocation. · Runoff from fire control or dilution water may cause pollution.


PROTECTIVE CLOTHING · Wear positive pressure self-contained breathing apparatus (SCBA). · Structural firefighters' protective clothing will only provide limited protection.

EVACUATION Large Spill · Consider initial downwind evacuation for at least 300 meters (1000 feet). Fire · If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

EMERGENCY RESPONSE Fire CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. Small Fire · Dry chemical, CO2, water spray or alcohol-resistant foam. · Do not use dry chemical extinguishers to control fires involving nitromethane or nitroethane. Large Fire · Water spray, fog or alcohol-resistant foam. · Do not use straight streams. · Move containers from fire area if you can do it without risk. Fire involving Tanks or Car/Trailer Loads · Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. · Cool containers with flooding quantities of water until well after fire is out. · Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. · ALWAYS stay away from tanks engulfed in fire. · For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. SPILL OR LEAK · ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). · All equipment used when handling the product must be grounded. · Do not touch or walk through spilled material. · Stop leak if you can do it without risk. · Prevent entry into waterways, sewers, basements or confined areas. · A vapor suppressing foam may be used to reduce vapors. · Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. · Use clean non-sparking tools to collect absorbed material. Large Spill · Dike far ahead of liquid spill for later disposal. · Water spray may reduce vapor; but may not prevent ignition in closed spaces.

FIRST AID · Move victim to fresh air. · Call 911 or emergency medical service. · Give artificial respiration if victim is not breathing. · Administer oxygen if breathing is difficult. · Remove and isolate contaminated clothing and shoes. · In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. · Wash skin with soap and water. · In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. · Keep victim warm and quiet. · Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. · Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd. 1. Ethanol:

A. General Details • Synonyms: Absolute Ethanol, alcohol,alcohol anhydrous, alcohol dehydrated,alcohol

ethyl,algrain,anhydrol,cologne spirit,ethyl hydrate • Molecular Formula: C2-H6-O • Molecular Weight: 46.07

B. NFPA Classification Health: 2 (Moderate) Materials that, on intense or continued (but not chronic) exposure, could cause temporary incapacitation or possible residual injury, including those requiring the use of respiratory protective equipment that has an independent air supply. These materials are hazardous to health, but areas may be entered freely if personnel are provided with full-face mask self-contained breathing apparatus that provides complete eye protection. Flammability: 3 (Serious) This degree includes Class IB and IC flammable liquids and materials that can be easily ignited under almost all normal temperature conditions. Water may be ineffective in controlling or extinguishing fires in such materials. Instability: 0 (Minimal) This degree includes materials that are normally stable, even under fire exposure conditions, and that do not react with water. Normal fire fighting procedures may be used.

C. Hazardous Property • FLAMMABLE LIQUIDS (Polar / Water-Miscible)

o HIGHLY FLAMMABLE: Easily ignited by heat, sparks or flames o CAUTION: Very low flash point; use of water spray when fighting fire may be

inefficient

D. Storage Condition • Keep tightly closed, cool and away from flame. • Storage temp: ambient Venting: open (flame arrester) or pressure vacuum. • Protect containers against physical damage Underground storage tanks outside the

building is preferred for use of large quantities Small amt may be stored outside the building in the original shipping containers Should not be stored with perchlorates, peroxides, chromic acid and nitric acid.

E. Exposure Limits • IDLH:300 ppm • TLV: 8 hr Time Weighted Avg (TWA): 1000 ppm. • OSHA Standard: Permissible Exposure Limit:8-hr Time Weighted Avg: 1000 ppm (1900

mg/cu m).

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Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd.

F. Health Effects 0.1.1 SUMMARY OF EXPOSURE

• 0.1.1.1 ACUTE EXPOSURE o A) USES: Found primarily in alcoholic beverages. Also found in a variety of over-the-

counter products including some cough/cold medicines, perfumes, colognes, mouthwashes, food flavorings (vanilla extract) and hand sanitizers. Also used clinically as a treatment of ethylene glycol or methanol poisonings.

o B) PHARMACOLOGY: When used therapeutically, ethanol's high affinity for alcohol dehydrogenase inhibits the metabolism of methanol and ethylene glycol.

o C) TOXICOLOGY: Ethanol enhances the inhibitory effects of GABA at the GABA-A receptor. It also competitively inhibits the binding of glycine at the NMDA receptor, disrupting excitatory glutaminergic neurotransmission. The net result is CNS depression. Chronic ethanol use causes desensitization and down-regulation of GABA-A receptors and NMDA up-regulation. Abrupt cessation of ethanol use then causes a hyperexcitable state, producing the ethanol withdrawal syndrome. Please refer to the ALCOHOL WITHDRAWAL SYNDROMES management for further information.

o D) EPIDEMIOLOGY: Extremely common exposure, which rarely results in morbidity or death. However, ethanol is a frequent precipitant of traumatic injury.

o E) WITH POISONING/EXPOSURE 1) MILD TO MODERATE TOXICITY: Intoxication, euphoria, ataxia, nystagmus,

disinhibition, aggressive behavior, nausea, vomiting, flushing, supraventricular tachydysrhythmias (primarily atrial fibrillation) can develop.

2) SEVERE TOXICITY: Coma, respiratory depression, pulmonary aspiration, hypoglycemia and hypothermia can occur. Abrupt cessation of chronic ethanol use causes withdrawal, manifested by hypertension, tachycardia, tremors, seizures, and in severe cases delirium.

0.1.3 VITAL SIGNS • 0.1.3.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Hypothermia is common. Hypotension and tachycardia may be present.

Bradypnea may occur early, and tachypnea may develop in cases of metabolic acidosis. Elevated body temperature and labored breathing (possibly from aspiration) have been reported in infants.

0.1.5 CARDIOVASCULAR • 0.1.5.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Atrial fibrillation and atrioventricular block have been reported with

acute overdose. Cardiac arrest has been reported in a pediatric case. Cardiac output may be decreased in persons with pre-existing cardiac disease.

2) After consuming recreational amounts of alcohol, persons suffering from variant angina may experience chest pain due to coronary artery spasm or myocardial ischemia.

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3) Sudden cardiac failure, arrhythmias, subclinical left ventricular dysfunction, and other morphologic abnormalities of the heart can occur with chronic heavy abuse.

0.1.6 RESPIRATORY • 0.1.6.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Respiratory depression may occur. Respiratory failure may follow severe

intoxication. Aspiration of vomitus may result in pneumonitis and pulmonary edema.

0.1.7 NEUROLOGIC • 0.1.7.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) ACUTE: Intoxication is characterized by confusion, ataxia, emotional

lability, perceptual and sensation disturbances, possible blackout spells, and incoordination with impaired objective performance in standardized tests. CNS depression may progress to coma. Seizures due to hypoglycemia have been reported in children.

2) CHRONIC: Wernicke's encephalopathy, Korsakoff's psychosis, dependence and withdrawal, as well as chronic cerebellar syndrome can occur.

0.1.8 GASTROINTESTINAL • 0.1.8.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Nausea, vomiting, gastrointestinal bleeding and abdominal pain are

common. Diarrhea may occur. 0.1.9 HEPATIC

• 0.1.9.1 ACUTE EXPOSURE o A) WITH POISONING/EXPOSURE

1) Acute hepatitis can occur. Acute ethanol ingestion has been associated with a significant increase in the rate of acetylation.

2) Chronic use of ethanol has been associated with steatosis, necrosis, cirrhosis, depletion of vitamin A, and inhibition of glycogen storage, and may increase the risk of hepatotoxicity following exposure to some chemicals.

0.1.11 ACID-BASE • 0.1.11.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Lactic or ketoacidosis may occur. Acidosis may occur due to metabolic

disturbances, such as NADH overproduction, oxidation of ethanol, decreased lactate utilization, and inhibition of hepatic gluconeogenesis.

0.1.13 HEMATOLOGIC • 0.1.13.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Anemia and thrombocytopenia can occur in alcoholics. An unusual case

of pancytopenia has been reported in an alcoholic. 0.1.14 DERMATOLOGIC

• 0.1.14.1 ACUTE EXPOSURE

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o A) WITH POISONING/EXPOSURE 1) Ethanol can cause facial flushing, skin dryness and irritation. Allergic

contact urticaria, possibly from impurities, may occur. Toxicity from dermal absorption through intact or damaged skin has occurred in pediatric cases.

0.1.15 MUSCULOSKELETAL • 0.1.15.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Acute and chronic skeletal myopathies have been recorded in ethanol

abusers. Myoglobinuria, muscle weakness and brachial plexopathy have occurred following large ethanol ingestions.

2) Chronic ethanol abusers have been found to have lower bone density, higher serum calcium levels and may develop rhabdomyolysis.

0.1.16 ENDOCRINE • 0.1.16.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Hypoglycemia leading to seizures or coma can be a complication of

ethanol intoxication. Hyperglycemia has also been seen, especially in alcoholics found to be acidotic.

2) Some chronic alcohol abusers show characteristics of pseudo-Cushing's syndrome which disappear with ethanol discontinuation. Increases in plasma prolactin, decreases in plasma testosterone, cortisol and adrenocorticotropic hormone levels have been seen following acute ethanol ingestion.

0.1.19 IMMUNOLOGIC • 01.19.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Anaphylaxis following the ingestion of ethanol has been rarely reported.

Sensitization has also been occasionally reported. Contaminants, metabolites or additives may be the cause of these responses.

0.1.20 REPRODUCTIVE HAZARDS • A) Women who consume ethanol during pregnancy may give birth to a child with Fetal

Alcohol Syndrome. No safe consumption level is known. 0.1.21 CARCINOGENICITY

• 0.2.21.1 IARC CATEGORY o A) IARC Carcinogenicity Ratings for CAS64-17-5 (IARC, 2004):

1) Not Listed • 0.2.21.2 HUMAN OVERVIEW

o A) Alcohol consumption has been associated with various cancers, including liver cancer, esophageal cancer, breast and prostate cancer, and colorectal cancer.

0.1.22 GENOTOXICITY • A) Ethanol caused DNA damage in a rat model and S cerevisiae, DNA repair in E coli, and

DNA inhibition in human lymphocytes. It caused mutations in E coli, S typhimurium, A nidulans, and S cerevisiae. It has been positive on cytogenetic analysis in human fibroblasts, leukocytes, and lymphocytes; in rats and mice; and in hamster embryo and ovary cells.

• B) A positive micronucleus test was observed in mice and in dog lymphocytes. The dominant lethal test was positive in mice, sperm morphology was observed in mice, and ethanol was positive for gene conversion/mitotic recombination in A nidulans.

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• C) Ethanol has caused sister chromatid exchange in human lymphocytes, hamster ovary cells, and in mice. It also caused sex chromosome loss/nondisjunction in A nidulans, D melanogaster, and in mice.

G. Laboratory Test

• Obtain an ethanol concentration (either blood or breath). • A bedside dextrose is indicated for patients with an altered mental status. • Consider a head CT for comatose patients or those with evidence of trauma.

Monitor serum chemistries. • Obtain arterial or venous blood gases, and serum and urine ketones for alcoholic

ketoacidosis.

H. Treatment Overview 0.1.2 ORAL EXPOSURE

• A) MANAGEMENT OF MILD TO MODERATE TOXICITY o 1) Patients who appear mildly intoxicated may be simply managed with supportive

care only. An ethanol concentration is generally not needed for management. Patients can be discharged when they are not clinically intoxicated (no ataxia, nystagmus or slurred speech). Significant CNS depression indicates a more severe poisoning.

• B) MANAGEMENT OF SEVERE TOXICITY o 1) Measure a serum ethanol level if ethanol is believed to be the cause of altered

mental status and consider and rule-out other reversible causes of altered mental status such as hypoglycemia, hypoxia, and opiate intoxication. Patients who are comatose may require airway protection. Other causes of altered mental status should be considered as ethanol is often a coingestant with other drugs and intoxicated patients are predisposed to traumatic injuries. Children may be susceptible to hypoglycemia following an ethanol ingestion. Alcoholic ketoacidosis is a condition that typically develops in chronic drinkers that results in impaired gluconeogenesis. It often develops after binge drinking combined with malnutrition. Vomiting, abdominal pain, and an anion gap metabolic acidosis develop. Treatment is with fluid replacement and dextrose supplementation. Thiamine, folate, and other vitamins should also be provided intravenously. Ethanol withdrawal is a potentially life-threatening condition that may result in chronic drinkers following a period of abstinence. It usually begins with autonomic hyperactivity, tachycardia, tremor, hypertension, agitation leading to hallucinations and seizures. Treatment is generally with benzodiazepines for sedation. In patients with resistant symptoms, consider the use of propofol or a barbiturate such as phenobarbital.

• C) DECONTAMINATION o 1) PREHOSPITAL: There is no role for prehospital decontamination. o 2) HOSPITAL: Activated charcoal is not indicated because it poorly adsorbs to

ethanol, but may be used in the appropriate conditions if there are coingestants. Consider the use of nasogastric suction for patients that present with massive ingestions within 30 minutes, which is rarely indicated.

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• D) AIRWAY MANAGEMENT o 1) Patients who are comatose or with an altered mental status may need

orotracheal intubation and mechanical ventilation. • E) ANTIDOTE

o 1) There is no specific antidote. • F) ENHANCED ELIMINATION

o 1) Hemodialysis can eliminate ethanol, but is rarely indicated. Consider in patients with severe intoxication (eg, hypotension) not responding to supportive care.

• G) PATIENT DISPOSITION o 1) HOME CRITERIA: Patients who are minimally intoxicated with no use of

coingestants can be observed at home if there is another responsible nonintoxicated adult. Symptomatic children or children with ingestions that are expected to cause more than minimal symptoms should be referred to a health care facility.

o 2) OBSERVATION CRITERIA: Patients should be observed until they are not clinically intoxicated. If they are minimally intoxicated and there is a responsible nonintoxicated adult that can provide care, and there is no evidence of trauma or other medical problems, they can potentially be discharged depending on the circumstances. Refer patients with chronic alcoholism or high risk drinking for detoxification and rehabilitation.

o 3) ADMISSION CRITERIA: Admit patients with unstable vital signs, altered mental status that does not improve, concerning coingestants, associated serious trauma or medical conditions, or signs and symptoms of withdrawal.

o 4) CONSULT CRITERIA: Consult a poison center or medical toxicologist for assistance in managing severe poisonings.

• H) PITFALLS o 1) Ethanol is often a coingestant with other drugs. Intoxicated patients are

predisposed to traumatic injuries, which may be more difficult to diagnose in an intoxicated patient. Ethanol can account for an elevated osmolar gap. Small amounts of concentrated ethanol solutions may result in significant toxicity in children.

• I) PHARMACOKINETICS o 1) Well absorbed (80% to 90%). Peak concentrations are achieved within 0.5 to 1.5

hours after a single ingestion. Volume of distribution is approximately 0.6 L/kg. Hepatically metabolized, primarily by alcohol dehydrogenase (which is saturable at low ethanol concentrations), and to a lesser extent by cytochrome P2E1 (which is inducible with chronic consumption) and by the peroxidase-catylase system.

• J) TOXICOKINETICS o 1) Elimination changes from first order to zero order kinetics at low blood ethanol

concentrations. Nontolerant drinkers typically eliminate ethanol at a rate of approximately 15 to 20 mg/dL/hr, while chronic drinkers have an elimination rate of approximately 20 to 30 mg/dL/hr. Patients also develop tolerance to some effects.

• K) DIFFERENTIAL DIAGNOSIS o 1) The differential diagnosis includes other xenobiotics that present with

intoxication including ingestions of isopropanol and methanol, benzodiazepines,

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barbiturates, and GHB. The differential diagnosis of altered mental status is extremely broad and includes toxicologic and nontoxicologic causes.

• L) DRUG INTERACTIONS o 1) Coingestions with other CNS and respiratory depressants (eg, benzodiazepines,

barbiturates, opioids) increases toxicity.

I. EMERGENCY ACTION GUIDELINES: • Fire Fighting Procedure:

o The most appropriate extinguishers are carbon dioxide and dust; Water may be used, provided it is /used/ in large amounts.

o Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical.

• Protective Equipment & Clothing: o All-purpose canister; safety goggles. o Personal protective equipment should be provided where there is prolonged

skin contact. o Protective clothing should be worn by persons who are exposed to ethanol and

should be composed of natural rubber, neoprene, nitrile, or vitron as these compounds have breakthrough times (ie the time it takes for a compound to move from the outer surface of protective clothing to the inner surface) of at least an hour or more.

o Breakthrough times greater than one hour reported by (normally, two or more testers for butyl rubber (butyl), natural rubber (nat.rub) neoprene (neop), nitrile rubber (nitrile) and viton. Breakthrough times less (usually significantly less) than one hour reported by (normally) two or more testers for polyvinyl alcohol (PVA) and polyvinyl chloride (PVC). No data for neoprene/styrene-butadiene rubber (neop/SBR), nitrile rubber/polyvinyl chloride (nitrile/PVC), polyethylene (PE), polyurethane (PU), and styrene-butadiene rubber (SBR).

o Wear appropriate personal protective clothing to prevent skin contact. o Wear appropriate eye protection to prevent eye contact. o Respirator Recommendations: Up to 3300 ppm: (Assigned Protection Factor =

10) Any supplied-air respirator/(Assigned Protection Factor = 50) Any self-contained breathing apparatus with a full facepiece.

o Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned Protection Factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(Assigned Protection Factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.

o Respirator Recommendations: Escape: Any appropriate escape-type, self-contained breathing apparatus.

7


• Cleanup Method: o Land spill: Apply appropriate foam to diminish vapor and fire hazard. o Water spill: Use natural barriers or oil spill control booms to limit spill travel.

Allow to aerate. o Air spill: Apply water spray or mist to knock down vapors.

• Disposal Method:

o SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

o The following wastewater treatment technologies have been investigated for ethanol: Biological Treatment.

• ERPG GUIDE: Please refer Emergency Response Guide No. 127 enclosed in Annexure-____

for detailed Emergency Actions.

2. 2-Ethyl hexanol: A. General Details

• Synonyms: 2-ETHYL HEXANOL, (.+-.)-2-ETHYL-1-HEXANOL, 2-ETHYL-1-HEXANOL, ETHYLHEXANOL, 2-ETHYLHEXANOL, 2-ETHYLHEXYL ALCOHOL, OCTYL ALCOHOL.

• Molecular Formula: C8H18O • Molecular Weight: 130.23

B. NFPA Classification

Health: 2 (Moderate) Materials that, on intense or continued (but not chronic) exposure, could cause temporary incapacitation or possible residual injury, including those requiring the use of respiratory protective equipment that has an independent air supply. These materials are hazardous to health, but areas may be entered freely if personnel are provided with full-face mask self-contained breathing apparatus that provides complete eye protection. Flammability: 2 (Serious) This degree includes materials that must be moderately heated before ignition will occur and includes Class II and IIIA combustible liquids and solids and semi-solids that readily give off ignitible vapors. Waterspray may be used to extinguish fires in these materials because the materials can be cooled below their flash points. Instability: 0 (Minimal)

8

https://pubchem.ncbi.nlm.nih.gov/compound/Water


This degree includes materials that are normally stable, even under fire exposure conditions, and that do not react with water. Normal fire fighting procedures may be used.

C. Hazardous Property • COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

D. Storage Condition • Keep container tightly closed in a dry and well-ventilated place. Containers which are

opened must be carefully resealed and kept upright to prevent leakage. E. Exposure Limits

• IDLH: Not listed • TLV: Not listed • OSHA Standard: Not listed

F. Health Effects

• Anesthesia, nausea, headache, dizziness; mildly irritating to skin and eyes G. Laboratory Test

• measured VOC emissions /of 2-Ethyl-1-hexanol/ from the floors using double-cylinder chambers and the airborne concentrations of phthalate esters by filtration sampling, both by GC-MS.Abstract

• The diffusive sampling method is effective for the measurement of a low level of 2-ethyl-1-hexanol in indoor air Abstract.

• Determination of phthalate contaminants in iv solutions stored in pvc bags by gc-single-ion monitoring mass spectrometry.

• Capillary column GC with FID detection. Linear response over 0-50 ug/mL, the range of concentrations considered. Limit of determination 0.5 ug/L.

H. Treatment Overview • Immediate first aid: Ensure that adequate decontamination has been carried out. If

patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds.

• Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary Monitor for pulmonary edema and treat if necessary Anticipate seizures and treat if necessary For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal Higher alcohols (>3 carbons) and related compounds.

9

https://pubchem.ncbi.nlm.nih.gov/compound/water

https://pubchem.ncbi.nlm.nih.gov/compound/phthalate


https://pubchem.ncbi.nlm.nih.gov/compound/oxygen




• Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema Monitor cardiac rhythm and treat arrhythmias as necessary Start IV administration of D5W /SRP: "To keep open", minimal flow rate Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary Treat seizures with diazepam or lorazepam Use proparacaine hydrochloride to assist eye irrigation Higher alcohols (>3 carbons) and related compounds.


o Use water spray, alcohol-resistant foam, dry powder, carbon dioxide. o Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical

or carbon dioxide. o Use water spray to cool unopened containers. o Wear self contained breathing apparatus for fire fighting if necessary. o To fight fire, use foam, carbon dioxide, dry chemical.

• Protective Equipment & Clothing: o Personnel protection: Wear appropriate chemical protective gloves, boots, and

goggles. o Eye/face protection: Face shield and safety glasses. Use equipment for eye

protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

o Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

o Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

o Contain spillage, and then collects with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulation Keep in sutable, closed containers for disposal.

• Cleanup Method:

o Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

10

https://pubchem.ncbi.nlm.nih.gov/compound/D5W

https://pubchem.ncbi.nlm.nih.gov/compound/dextrose

https://pubchem.ncbi.nlm.nih.gov/compound/dextrose

https://pubchem.ncbi.nlm.nih.gov/compound/diazepam

https://pubchem.ncbi.nlm.nih.gov/compound/lorazepam

https://pubchem.ncbi.nlm.nih.gov/compound/proparacaine%20hydrochloride


https://pubchem.ncbi.nlm.nih.gov/compound/carbon%20dioxide






o Contain spillage, and then collects with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulation ... Keep in sutable, closed containers for disposal.

o Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.


o Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.

o Contaminated packaging: Dispose of as unused product. o The most favorable course of action is to use an alternative chemical product with

less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

• ERPG GUIDE: Please refer Emergency Response Guide No. 131 enclosed in Annexure-____

for detailed Emergency Actions.

3. IPA (ISO PROPYL ALCOHOL): A. General Details

• Synonyms: Avantine, Dimethylcarbinol, i-Propyl alcohol, Imsol A, IPA, Isohol, Isopropyl Alcohol, Lutosol, n-Propan-2-ol, Petrohol, PRO, Propan-2-ol, sec-Propyl Alcohol, Secondary Propyl Alcohol

• Molecular Formula: C3-H8-O • Molecular Weight: 60.10

B. NFPA Classification Health: 1 (Slight) Materials that, on exposure, would cause significant irritation, but only minor residual injury, including those requiring the use of an approved air-purifying respirator. These materials are only slightly hazardous to health and only breathing protection is needed. Flammability: 3 (Serious) This degree includes Class IB and IC flammable liquids and materials that can be easily ignited under almost all normal temperature conditions. Water may be ineffective in controlling or extinguishing fires in such materials. Instability: 0 (Minimal) This degree includes materials that are normally stable, even under fire exposure conditions, and that do not react with water. Normal fire fighting procedures may be used.

11


Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd. C. Hazardous Property

• FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious) o HIGHLY FLAMMABLE: Easily ignited by heat, sparks, flames o CAUTION: Very low flash point; use of water spray when fighting fire may be

inefficient o Do not use straight streams

D. Storage Condition

• Storage Temperature – Ambient in isolated storage of flammable liquids E. Exposure Limits

• IDLH:2000 ppm • TLV: 8 hr Time Weighted Avg (TWA): 200 ppm; Short Term Exposure Limit (STEL): 400 ppm • OSHA Standard:

o Permissible Exposure Limit: 8-hr Time Weighted Avg: 400 ppm (980 mg/cu m). o Vacated 1989 OSHA PEL TWA 400 ppm (980 mg/cu m); STEL 500 ppm (1225 mg/cu m) is

still enforced in some states F. Health Effects

0.1.1 SUMMARY OF EXPOSURE • 0.1.1.1 ACUTE EXPOSURE

o A) USES: Primarily used as a topical antiseptic. Typical household preparations contain 70% isopropanol. Also used as a solvent in many household, cosmetic, and topical pharmaceutical products. Isopropanol baths are occasionally used in some cultural practices to relieve fevers.

o B) TOXICOLOGY: CNS depressant and gastrointestinal (GI) irritant; acetone (metabolite) likely contributes to CNS depression.

o C) EPIDEMIOLOGY: The most common toxic alcohol exposure reported to poison centers in the United States. Cases occur in the thousands, but toxicity is rarely severe.

o D) WITH POISONING/EXPOSURE 1) MILD TO MODERATE TOXICITY: May include CNS depression, dysarthria,

ataxia, nystagmus, similar to ethanol intoxication, nausea/vomiting, flushing, headache, tachycardia, mild hyperglycemia, ketonuria, and ketonemia WITHOUT metabolic acidosis.

2) SEVERE TOXICITY: May include hemorrhagic gastritis, hypotension, respiratory depression, and coma. Death is rare and likely secondary to respiratory depression and aspiration.

3) EYE EXPOSURE: Splash or vapor exposure causes irritation. 4) DERMAL EXPOSURE: Repeated dermal application can cause systemic toxicity

(primarily CNS depression), especially in infants and young children, because of more extensive dermal absorption and greater surface area-to-volume ratios.

5) PARENTERAL EXPOSURE: CNS and respiratory depression are possible; hemolysis has developed in 1 patient.

12

Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd. 0.1.2 VITAL SIGNS

• 0.1.2.1 ACUTE EXPOSURE o A) Ingestion, dermal absorption, or inhalation commonly cause tachycardia.

Hypothermia, bradycardia, and hypotension may occur with severe poisoning. 0.1.3 HEENT

• 0.1.3.1 ACUTE EXPOSURE o A) Eye discomfort without significant injury occurs with brief vapor or splash exposure

(70% solution). o B) Temporary changes in the corneal epithelium may develop after prolonged vapor

exposure. Moderate irritation has been produced in animal eye tests. 0.1.4 CARDIOVASCULAR

• 0.1.4.1 ACUTE EXPOSURE o A) Tachycardia is common. Hypotension and bradycardia may occur in severe

poisonings. 0.1.5 RESPIRATORY

• 0.1.5.1 ACUTE EXPOSURE o A) Respiratory depression and failure can occur in cases of severe poisoning from

inhalation, ingestion, or parenteral exposure. Tracheobronchitis may occur. 0.1.6 NEUROLOGIC

• 0.1.6.1 ACUTE EXPOSURE o A) CNS depression is common, ranging from disorientation and lethargy to coma.

Dysarthria, ataxia, and nystagmus may develop. Diminished or absent deep tendon reflexes are common. Seizures and increased CSF protein levels are rare effects.


o A) Vomiting and gastritis may occur. Hemorrhagic gastritis and associated anemia may be present.

0.1.8 GENITOURINARY • 0.1.8.1 ACUTE EXPOSURE

o A) Acute renal tubular necrosis has been reported in patients with hypotension or rhabdomyolysis. Myoglobinuria has been reported.


o A) Ketosis and ketonuria are common. Significant metabolic acidosis is rare. 0.1.10 HEMATOLOGIC

• 0.1.10.1 ACUTE EXPOSURE o A) Hemolysis may occur after exposure.

0.1.11 DERMATOLOGIC • 0.1.11.1 ACUTE EXPOSURE

o A) Dermal irritation and burns may develop from chronic use or prolonged contact. Systemic absorption may occur following dermal application, particularly in infants.

13

Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd. 0.1.12 MUSCULOSKELETAL

• 0.1.12.1 ACUTE EXPOSURE o A) Rhabdomyolysis may occur following exposure.

0.1.13 ENDOCRINE • 0.1.13.1 ACUTE EXPOSURE

o A) Mild hyperglycemia is often reported in adults. Children may be at greater risk for developing hypoglycemia.

0.1.14 REPRODUCTIVE HAZARDS • A) At the time of this review, no reproductive studies were found for isopropanol in humans.

0.1.15 CARCINOGENICITY • 0.1.15.1 IARC CATEGORY

o A) IARC Carcinogenicity Ratings for CAS67-63-0 (IARC, 2004): 1) IARC Classification

a) Listed as: Isopropanol b) Carcinogen Rating: 3

1) The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.

2) IARC Classification a) Listed as: Isopropanol manufacture (strong-acid process) b) Carcinogen Rating: 1

1) The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity.

• 0.1.15.2 HUMAN OVERVIEW o A) Isopropanol is not regarded as a human carcinogen at the present time. o B) Some studies reported an increased incidence of paranasal, laryngeal, and pharynx

cancers, but this was felt to be related to other chemicals used in the manufacture of isopropanol using the strong acid method.

14


• 0.1.15.3 ANIMAL OVERVIEW o A) Isopropyl alcohol has not been carcinogenic in experimental animals. A slight increase

in interstitial testicular cell adenomas following inhalation exposure has been seen. 0.1.16 GENOTOXICITY

• A) Isopropanol has not been genotoxic in a variety of short-term tests.

G. Laboratory Test • Monitor vital signs and mental status. • Obtain a metabolic panel, serum isopropyl alcohol and acetone concentrations. Ketonemia

and ketonuria may present within 1 to 3 hours of ingestion, but acidosis is NOT expected. Isopropanol elevates measured serum osmolality.

• Monitor for evidence of hemorrhagic gastritis (hemoccult stools, gastroccult emesis, hematocrit)


• A) MANAGEMENT OF MILD TO MODERATE TOXICITY o 1) Supportive care. There is no indication for activated charcoal or other GI

decontamination. • B) MANAGEMENT OF SEVERE TOXICITY

o 1) Critically ill patients will need emergent management of airway, breathing, and circulation. CNS depression may require intubation, and alcohol-induced vasodilation and vomiting may lead to hypotension requiring fluid resuscitation, and rarely vasopressors.

• C) DECONTAMINATION o 1) PREHOSPITAL: Do not administer prehospital ipecac or activated charcoal,

because of limited utility and the risk of aspiration if CNS depression develops. Irrigate exposed eyes with water. Wash exposed skin with soap and water and remove contaminated clothing.

o 2) HOSPITAL: Activated charcoal and gastric lavage are not indicated. Consider simple nasogastric tube aspiration for large, recent ingestions if the airway is protected.

• D) AIRWAY MANAGEMENT o 1) May be necessary after large ingestions if the patient's mental status is so

depressed they cannot protect their airway. • E) ANTIDOTE

o 1) No specific antidote is available. • F) ENHANCED ELIMINATION

o 1) Hemodialysis could be considered in extreme cases; however, most patients should improve with supportive care. Dialysis should be considered when levels

15


are extremely high (eg, greater than 500 to 600 mg/dL) or if hypotension does not respond to fluids and vasopressors.

• G) PATIENT DISPOSITION o 1) HOME CRITERIA: Asymptomatic children (other than mild drowsiness) with an

acute inadvertent ingestion may be monitored at home. Children younger than 6 years old who have ingested 30 mL or greater are more likely to become symptomatic and should be referred for evaluation and treatment.

o 2) OBSERVATION CRITERIA: Patients with deliberate ingestions or any patient who manifests symptoms should be sent to a health care facility for observation until symptoms resolve.

o 3) ADMISSION CRITERIA: Patients with significant persistent CNS toxicity (somnolence, intoxication, coma), hypotension or severe hemorrhagic gastritis should be admitted to an intensive care setting.

o 4) CONSULT CRITERIA: Consult the poison center or medical toxicologist for assistance in managing patients with severe toxicity (eg, coma) or in whom the diagnosis is not clear.

• H) PITFALLS o 1) Missing an ingestion of another toxic alcohol (eg, ethylene glycol, methanol) or

other possible etiologies for a patient's symptoms. In cases of hemorrhagic gastritis, it is imperative the patient's hemoglobin is stable.

• I) PHARMACOKINETICS o 1) Isopropanol is well absorbed by the body and quickly distributes into body fluids

(volume of distribution 0.6 L/kg). It is metabolized by alcohol dehydrogenase to acetone (half-life of 2.5 to 3 hours).

• J) DIFFERENTIAL DIAGNOSIS o 1) CNS DEPRESSION: Other toxic alcohols, benzodiazepines, opiates/opiods,

antipsychotic medications o 2) KETOSIS: Ethanol (alcoholic ketoacidosis), diabetic ketoacidosis, starvation

ketosis o 3) GASTRITIS: Nonsteroidal anti-inflammatories, heavy metals

0.1.2 INHALATION EXPOSURE • A) Supportive care.

0.1.3 EYE EXPOSURE • A) Irrigate with water or normal saline, slit lamp examination if irritation persists.

0.1.4 DERMAL EXPOSURE • A) OVERVIEW

o 1) Wash exposed skin with soap and water and remove contaminated clothing. Supportive care

16

Chemical Safety Plan of M/s. Heni Drugs Pvt. Ltd. I. EMERGENCY ACTION GUIDELINES:

• Fire Fighting Procedure: o Do not extinguish fire unless flow can be stopped. Use water in flooding quantities

as fog. o Solid streams of water may be ineffective. o Cool all affected containers with flooding quantities of water. Apply water from as

far a distance as possible. o Use "alcohol" foam, dry chemical or carbon dioxide.

• Protective Equipment & Clothing:

o Wear safety glasses, rubber gloves, a face shield, coveralls ... . o The following materials are acceptable: neoprene, PVC, paracril/PVC, chlorinated

polyethylene, butyl rubber, natural rubber, nitrile, vitron. Unacceptable: PVA. Conditionally acceptable: polyurethane. Note: This ... is ... a guide only. The user is advised to contact the protective clothing manufacturer regarding the specific applicability & limitations of a material under proposed conditions of use.

o Wear appropriate chemical protective ... boots and goggles. o Breakthrough times greater than one hour reported by (normally) two or more

testers for neoprene and nitrile rubber. Some data (usually from immersion tests) suggesting breakthrough times greater than one hour are not likely for natural rubber. No data for butyl rubber, neoprene/styrene-butadiene rubber, nitrile rubber/polyvinyl chloride, polyethylene, polyvrethane, polyvinyl alcohol, and viton. Some data suggesting breakthrough times of approximated an hour or more for polyvinyl chloride.

o Wear appropriate personal protective clothing to prevent skin contact. o Wear appropriate eye protection to prevent eye contact. o Recommendations for respirator selection. Max concn for use: 2000 ppm.

Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Eye protection needed. Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s). Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any powered, air-purifying respirator with organic vapor cartridge(s). Eye protection needed. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.

o Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.

17


o Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister. Any appropriate escape-type, self-contained breathing apparatus.

• Cleanup Method: o If isopropyl alcohol is spilled or leaked ... 1. Remove all ignition sources. 2. Ventilate

area of spill or leak. 3. For small quantities absorb on paper towels. o Evaporate in a safe place (such as a fume hood). Allow sufficient time for

evaporating vapors to completely clear the hood ductwork. o Burn paper in suitable location away from combustible materials. o Large quantities can be collected & atomized in suitable combustion chamber.


o SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

• ERPG GUIDE.: Please refer Emergency Response Guide No. 129 enclosed in Annexure-____ for detailed Emergency Actions.

4. Monoethylene glycol: A. General Details

• Synonyms: 1,2-Dihydroxyethane ,1,2-Ethandiol, 2-Hydroxyethanol , Ethane-1,2-diol ,Ethylene Alcohol ,Ethylene Dihydrate ,Fridex ,Glycol, Monoethylene Glycol.

• Molecular Formula: C2-H6-O2 • Molecular Weight: 62.07

B. NFPA Classification Health: 2 (Moderate) Materials that, on intense or continued (but not chronic) exposure, could cause temporary incapacitation or possible residual injury, including those requiring the use of respiratory protective equipment that has an independent air supply. These materials are hazardous to health, but areas may be entered freely if personnel are provided with full-face mask self-contained breathing apparatus that provides complete eye protection. Flammability: 1 (Slight) This degree includes materials that must be preheated before ignition will occur, such as Class IIIB combustible liquids and solids and semi-solids whose flash point exceeds 200 deg F (93.4 deg C), as well as most ordinary combustible materials. Water may cause frothing if it sinks below the surface of the burning liquid and turns to steam. However, a water fog that is gently applied to the surface of the liquid will cause frothing that will extinguish the fire.

18


Instability: 0 (Minimal) This degree includes materials that are normally stable, even under fire exposure conditions, and that do not react with water. Normal fire fighting procedures may be used.

C. Hazardous Property • SUBSTANCES - TOXIC (Non-combustible)

o Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin

D. Storage Condition • Temperature: Ambient

E. Exposure Limits

• IDLH: • TLV: Ceiling Limit: 100 mg/cu m (Aerosol only). • OSHA Standard: Vacated 1989 OSHA PEL Ceiling value 50 ppm (125 mg/cu m) is still

enforced in some states.


• A) USES: Primarily used as an engine coolant (eg, antifreeze used in car radiators). • B) PHARMACOLOGY: No medical use. • C) TOXICOLOGY: Primary concern is the severe metabolic acidosis and nephrotoxicity from

metabolites. Metabolized by alcohol dehydrogenase (ADH) to glycoaldehyde and then by aldehyde dehydrogenase to glycolic acid. Glycolic acid is metabolized by lactate dehydrogenase or glycolic acid oxidase to glyoxylic acid which can be metabolized to oxalic acid. Specifically, oxalic acid metabolite complexes with calcium to form calcium oxalate crystals in the renal tubules that can lead to acute renal failure. Other intermediate metabolites are believed to be nephrotoxic as well. May have CNS effects believed mediated through GABA receptors.

• D) EPIDEMIOLOGY: There are thousands of exposures and several deaths every year reported to poison centers. Inadvertent pediatric ingestions rarely develop severe toxicity.

• E) WITH POISONING/EXPOSURE o 1) MILD TO MODERATE TOXICITY: Initially, ethylene glycol ingestion may cause

intoxication similar to ethanol with CNS depression, nystagmus, ataxia, and somnolence. Nausea and vomiting are also fairly common. If ethylene glycol metabolism is blocked early, there may be no other clinical manifestations.

o 2) SEVERE TOXICITY: If ethylene glycol metabolism is not blocked early after a significant ingestion, patients develop increasing CNS depression (coma, hypotonia, hyporeflexia, eventually cerebral edema), anion gap metabolic acidosis (often severe, arterial pH < 7.0 is common with severe ingestion), and renal failure. Seizures are common with severe toxicity, but usually not prolonged. Mild to moderate tachycardia is common, Kussmaul respirations develop with increasing acidosis, hypotension is rare. Hypocalcemia may result from precipitation of calcium oxalate crystals, which can (rarely) lead to cardiac dysrhythmias. In addition, there are reports of cranial nerve abnormalities developing 1 to 2 weeks

19


post exposure in patients with severe intoxication, which may be secondary to calcium oxalate crystal formation in the brain.

0.1.3 VITAL SIGNS • A) WITH POISONING/EXPOSURE

o 1) Hypothermia has been reported. 0.1.4 HEENT

• A) WITH POISONING/EXPOSURE o 1) Facial paralysis, nystagmus, strabismus, ophthalmoplegias, papilledema,

mydriasis, retinal injury, and eye and throat irritation may occur. 0.1.5 CARDIOVASCULAR

• A) WITH POISONING/EXPOSURE o 1) Cardiogenic pulmonary edema, cyanosis, cardiomegaly, myocarditis, and death

may occur. 0.1.6 RESPIRATORY

• A) WITH POISONING/EXPOSURE o 1) Tachypnea, respiratory irritation, and adult respiratory distress syndrome have

been reported following exposure to ethylene glycol. 0.1.7 NEUROLOGIC

• A) WITH POISONING/EXPOSURE o 1) CNS depression, seizures, coma, cerebral edema, cranial nerve deficits, and

delayed neurologic sequelae may be seen following ethylene glycol exposures. 0.1.8 GASTROINTESTINAL

• A) WITH POISONING/EXPOSURE o 1) Nausea and vomiting are frequent early findings.

0.1.10 GENITOURINARY • A) WITH POISONING/EXPOSURE

o 1) Classic pathologic findings include acute tubular necrosis and presence of calcium oxalate crystals in the kidneys.

o 2) The most uniform serious manifestation of poisoning is renal failure, with hematuria and proteinuria commonly seen.

0.1.11 ACID-BASE • A) WITH POISONING/EXPOSURE

o 1) Metabolic acidosis with an elevated anion gap is characteristic. However, a normal anion gap does not preclude a diagnosis of ethylene glycol toxicity.

0.1.12 FLUID-ELECTROLYTE • A) WITH POISONING/EXPOSURE

o 1) Hypocalcemia may occur. 0.1.13 HEMATOLOGIC

• A) WITH POISONING/EXPOSURE o 1) Pancytopenia, lymphocytosis, disseminated intravascular coagulation, and

leukocytosis have been reported. 0.1.14 DERMATOLOGIC

• A) WITH POISONING/EXPOSURE o 1) Ethylene glycol does not significantly irritate the skin. Slight maceration of the

skin may result from very severe, prolonged exposures. Cyanosis may occur 12 hours or longer post-ingestion.

0.1.15 MUSCULOSKELETAL

20


• A) WITH POISONING/EXPOSURE o 1) Myalgia and elevated CPK levels have been reported.

0.1.20 REPRODUCTIVE • A) Exposures to glycols have resulted in teratogenicity, specifically craniofacial and neural

tube closure defects and skeletal dysplasia in animal studies. 0.1.21 CARCINOGENICITY

• A) No data regarding carcinogenic effects in humans was found at the time of this review.

G. Laboratory Test • Obtain metabolic panel (serum electrolytes, including calcium), BUN and creatinine on all

patients with a history of ingestion. • Obtain blood ethanol and ethylene glycol concentration, if available. Can consider a

measured serum osmolality level if ethylene glycol concentration is not available. • Patients with significant toxicity should have arterial blood gas. • Obtain urinalysis with microscopy for calcium oxalate crystals. Hematuria and proteinuria

are also common. Monitor urine output.

H. Treatment Overview 0.1.2 ORAL/PARENTERAL EXPOSURE

• A) MANAGEMENT OF MILD TO MODERATE TOXICITY o 1) Monitor serum electrolytes, renal function and ethylene glycol concentration. A

peak ethylene glycol concentration < 20 mg/dL is commonly considered nontoxic. If the serum ethylene glycol concentration is >20 mg/dL, or there is a metabolic acidosis, or a history of a potentially toxic ingestion and ethylene glycol concentration is not rapidly available, administer an alcohol dehydrogenase inhibitor (either ethanol or fomepizole). In patients who present early after ingestion (before the development of metabolic acidosis), no further treatment may be required.

• B) MANAGEMENT OF SEVERE TOXICITY o 1) CNS depression may require intubation; adequate minute ventilation must be

insured to prevent abrupt worsening of acidemia. Alcohol-induced vasodilation and vomiting may lead to hypotension requiring fluid resuscitation. Alcohol dehydrogenase (ADH) inhibition is the most specific treatment for patients with severe ethylene glycol toxicity. Blockade (using ethanol or fomepizole) allows for excretion of ethylene glycol without formation of toxic metabolites (ADH has a much higher affinity for ethanol or fomepizole than for ethylene glycol). In patients who present late with metabolic acidosis and for most patients with very high ethylene glycol concentrations, hemodialysis will be necessary after ADH inhibition. Hemodialysis is the most definitive therapy for ethylene glycol poisoning as it clears both ethylene glycol and its toxic metabolites from the blood and corrects any resulting metabolic acidosis. Indications for hemodialysis include metabolic acidosis (serum pH < 7.2), signs of end-organ toxicity (eg, seizures and coma), and renal failure. Thiamine and pyridoxine are also administered to encourage metabolism of ethylene glycol to less toxic metabolites.

• C) DECONTAMINATION

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o 1) PREHOSPITAL: No ipecac or prehospital activated charcoal; no utility for therapy. If there is a dermal or eye exposure, it would be reasonable for simple decontamination with water at home.

o 2) HOSPITAL: Activated charcoal has no utility for ethylene glycol poisonings. Since ethylene glycol is a liquid, gastric lavage and whole bowel irrigation have no place in management. One could consider simple nasogastric tube aspiration for recent large ingestions, if the airway is protected.

• D) AIRWAY MANAGEMENT o 1) Intubation may be indicated if the patient's mental status is so depressed they

cannot protect their airway. The ventilator should be adjusted to assure that the patient is able to maintain any respiratory compensation for the metabolic acidosis. Failure to maintain ventilation can result in a dramatic fall in pH and cardiovascular collapse.

• E) ANTIDOTE o 1) Treat patients with either ethanol or fomepizole to block production of the toxic

metabolites of ethylene glycol. Indications include: a serum ethylene glycol concentration greater than 20 mg/dL; history of ethylene glycol ingestion with an osmolar gap greater than 10 mOsm/L (not accounted by ethanol or other alcohols); or a history or strong clinical suspicion of ethylene glycol ingestion and 2 of the following: serum bicarbonate less than 20 mEq/L, an arterial pH less than 7.3, or presence of oxalate crystals in the urine.

a) ETHANOL vs FOMEPIZOLE: Fomepizole is easier to use clinically, requires less monitoring, does not cause CNS depression or hypoglycemia, and may obviate the need for dialysis in some patients. Ethanol requires continuous administration and frequent monitoring of serum ethanol and glucose levels, and may cause CNS depression and hypoglycemia (especially in children). The drug cost associated with ethanol use is generally much lower than with fomepizole; however, other costs associated with ethanol use (continuous intravenous infusion, hourly blood draws and ethanol levels, possibly greater use of hemodialysis) may make the costs more comparable.

b) ETHANOL: Ethanol is given to maintain a serum ethanol concentration of 100 to 150 mg/dL. This can be accomplished by using a 5% to 10% ethanol solution administered intravenously through a central line. Intravenous therapy dosing, which is preferred, is 0.8 g/kg as a loading dose (8 mL/kg of 10% ethanol) administered over 20 to 60 minutes as tolerated, followed by an infusion rate of 80 to 150 mg/kg/hr (for 10% ethanol, 0.8 to 1.3 mL/kg/hr for a non-drinker; 1.5 mL/kg/hr for a chronic alcoholic). During hemodialysis, either add ethanol to the dialysate to achieve 100 mg/dL concentration or increase the rate of infusion during dialysis (for 10% ethanol, 2.5 to 3.5 mL/kg/hr). Oral ethanol may be used as a temporizing measure until intravenous ethanol or fomepizole can be obtained, but it is more difficult to achieve the desired stable ethanol concentration. The loading dose is 0.8 grams/kg (4 mL/kg of 20% {40 proof}) ethanol diluted in juice administered orally or via a nasogastric tube. Maintenance dose is 80 to 150 mg/kg/hour (of 20% {40 proof}) ethanol; 0.4 to 0.7 mL/kg/hour for a non-drinker; 0.8 mL/kg/hour for a chronic alcoholic). Concentrations

22


greater than 30% (60 proof) ethanol should be diluted. For both modalities, blood ethanol levels must be monitored hourly and adjusted accordingly, and both require patient monitoring in an ICU setting.

c) FOMEPIZOLE: Fomepizole is administered as a 15 mg/kg loading dose, followed by four bolus doses of 10 mg/kg every 12 hours. If therapy is needed beyond this 48 hour period, the dose is then increased to 15 mg/kg every 12 hours for as long as necessary. Fomepizole is also effectively removed by hemodialysis; therefore, doses should be repeated following each round of hemodialysis. In selected patients (those who present early, without metabolic acidosis or renal failure) hemodialysis may be avoided by use of intravenous fomepizole. In patients with high ethylene glycol concentrations, who are treated with fomepizole alone, several days may be required before ethylene glycol is eliminated by the kidneys; hemodialysis may be indicated.

d) THIAMINE: Administer 100 mg intravenously daily to stimulate the conversion of glyoxylate to alpha-hydroxy-beta-ketoadipate, a nontoxic metabolite.

e) PYRIDOXINE: Administer 100 mg intravenously daily, to allow adequate stores of cofactor necessary for the conversion of glyoxylate to nontoxic glycine.

• F) SEIZURES o 1) Administer intravenous benzodiazepines, barbiturates.

• G) ENHANCED ELIMINATION o 1) Hemodialysis is the definitive therapy for patients poisoned by toxic alcohols as it

clears both the parent alcohol and the toxic metabolites from the blood. In addition, it corrects metabolic acidosis, electrolyte abnormalities, and maintains fluid balance. Indications for hemodialysis include: metabolic acidosis (pH <7.

o 2) unresponsive to therapy; renal failure; ethylene glycol concentration of 50 mg/dL or more (unless patient is receiving fomepizole and is asymptomatic with normal arterial pH); deteriorating vital signs despite supportive care; electrolyte abnormalities not responding to conventional therapy. Many patients will require multiple courses of hemodialysis to clear ethylene glycol, and dosing of ethanol and fomepizole must be increased during hemodialysis.

• H) PATIENT DISPOSITION o 1) HOME CRITERIA: A recent consensus guideline recommends that children with an

observed lick, sip or taste ingestion or a known accidental ingestion of less than 10 mL in an adult can be monitored at home. All other exposures, including unwitnessed exposures, should be referred to a health care facility.

o 2) OBSERVATION CRITERIA: Patient exposures that do not meet criteria for home management or any patient with symptoms should be sent to a health care facility. Patients who have no acidosis, normal renal function and a nontoxic ethylene glycol concentration may be discharged. If it is not possible to measure ethylene glycol concentrations, it is reasonable to observe patients who have undetectable serum ethanol concentrations for a minimum of 8 hours. During this period, the serum pH, bicarbonate and creatinine should be monitored every 2 hours. If the patient has no symptoms, no metabolic acidosis and normal renal function after 8 to 12 hours of observation, the risk of significant ethylene glycol toxicity is very low.

23


o 3) ADMIT CRITERIA: Any patient showing definitive signs of ethylene glycol poisoning (worsening renal function, metabolic acidosis, etc.) should be admitted to the hospital. Patients who have co-ingested ethanol will likely require admission if serum ethylene glycol concentrations cannot be measured, as these patients may not develop toxicity for more than 12 hours after presentation. Any patient receiving ethanol therapy requires an ICU admission. Any patient that is otherwise well and receiving fomepizole therapy should be safe in a less monitored setting (may require monitoring for suicide risk).

o 4) CONSULT CRITERIA: Consult your local poison center for any ethylene glycol exposure, especially those requiring antidote treatment, hemodialysis, or if the history is unclear.

• I) PITFALLS o 1) A normal osmolar gap does NOT rule out a significant ethylene glycol exposure.

The Wood's lamp testing of urine for fluorescence to confirm or eliminate ethylene glycol exposure is NOT reliable. Laboratory and clinical findings change during the course of toxicity. Early in the course of severe poisonings, ethylene glycol concentration (and usually osmolar gap) are high, anion gap is low, and signs and symptoms are limited to inebriation and GI irritation. Late in the course of severe intoxication, severe anion gap acidosis is present along with severe CNS depression, renal insufficiency and calcium oxalate crystalluria, but ethylene glycol concentration and osmolar gap may be low.

• J) TOXICOKINETICS o 1) Ethylene glycol has a half-life of 3 to 5 hours via metabolism by ADH (zero-order

kinetics). In the setting of ADH blockade, elimination is entirely renal with a half-life of approximately 17 hours. Ethylene is well absorbed orally and is not protein bound, with a volume of distribution of about 0.8 L/kg.

• K) DIFFERENTIAL DIAGNOSIS o 1) CNS depression: Other toxic alcohols, benzodiazepines, opiates/opioids,

antipsychotic medications, etc. o 2) Elevated anion gap metabolic acidosis: Ketones, uremia, lactic acidosis, other

toxins (iron, methanol, etc.), or alcoholic ketoacidosis. o 3) Renal injury: Other nephrotoxic drugs (eg, NSAIDs, aminoglycoside antibiotics),

dehydration, etc. 0.1.3 INHALATION EXPOSURE

• A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.

0.1.4 EYE EXPOSURE • A) DECONTAMINATION: Irrigate exposed eyes with copious amounts of room temperature

water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.


o 1) DECONTAMINATION: Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.

24


I. EMERGENCY ACTION GUIDELINES:

• Fire Fighting Procedure: o If material on fire or involved in fire: Extinguish fire using agent suitable for type

of surrounding fire. (Material itself does not burn or burns with difficulty.) Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.

• Protective Equipment & Clothing: o Breakthrough times greater than one hour reported by (normally) two or more

testers for natural rubber (nat Rub), neoprene (neop), nitrile rubber (nitrile), polyethlene (PE), and polyvinyl chloride (PVC). Some data suggesting breakthrough times of approximately an hour or more for neoprene/natural rubber (Neop/Nat Rub) and polyvinyl alcohol (PVA). No data for butyl rubber (Butyl) Neoprene/styrene-butadiene (Neop/SBR), nitrile rubber/polyvinyl chloride (Nitrile/PVC), chlorinated polyethylene (CPE), polyurethane (PU), styrene-butadiene rubber (SBR), and viton.

o Wear appropriate personal protective clothing to prevent skin contact. o Wear appropriate eye protection to prevent eye contact.

• Cleanup Method:

o Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

o Environmental considerations: Air spill: Apply water spray or mist to knock down vapors.

o Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.


o The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

• ERPG GUIDE: Please refer Emergency Response Guide No. enclosed in Annexure-____ for

detailed Emergency Actions.

5. BROMINE: A. General Details

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• Synonyms: Bromine Solution • Molecular Formula: Br2 • Molecular Weight: 159.808

B. NFPA Classification Health: 1 (Slight) Can cause serious or permanent injury. Flammability: 3 (Serious) Will not burn under typical fire conditions. Instability: 0 (Minimal) Normally stable, even under fire conditions.

C. Hazardous Property

• SUBSTANCES - TOXIC and/or CORROSIVE (Non-Combustible) o TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or

death D. Storage Condition

• Store in cool, dry, well-ventilated location. Separate from oxidizing materials. • Due to the fire and explosion hazard, bromine must not be stored, transported, or treated

along with acetylene, butane, methane, benzene, turpentine, or metallic powders. Vessels containing bromine and its cmpd should be kept tightly closed. Large quantities should be stored out of doors, shielded from direct exposure to sunlight, and away from areas of acute fire hazard, high-temperature processes and, readily oxidizable materials.

E. Exposure Limits • IDLH: 3 ppm • TLV: 8 hr Time Weighted Avg (TWA): 0.1 ppm; 15 min Short Term Exposure Limit (STEL): 0.2

ppm. • OSHA Standard: Permissible Exposure Limit: 8-hr Time Weighted Avg: 0.1 ppm (0.7 mg/cu

m). F. Health Effects 0.1.1 SUMMARY OF EXPOSURE

• 0.1.1.1 ACUTE EXPOSURE o A) USES: Bromine is used in gold extraction, manufacture of pharmaceuticals,

ethylene bromide, and dyes, fire retardants, and as sanitation preparations for swimming pools and cooling towers.

o B) PHARMACOLOGY: As an alkaline corrosive, bromine may cause liquefaction necrosis. It can saponify the fats in the cell membrane, destroying the cell and allowing deep penetration into mucosal tissue. In gastrointestinal tissue, an initial inflammatory phase may be followed by tissue necrosis (sometimes resulting in perforation), then granulation and finally stricture formation.

o C) EPIDEMIOLOGY: Although bromine is found in shock treatments for swimming pools and spas and is available for consumer use, exposure has been infrequently reported.

o D) WITH POISONING/EXPOSURE

26


1) Bromine exposure is unusual; limited data regarding specific human toxicity following bromine exposure is available. The following effects could be expected to occur, based on exposure data of other alkaline corrosives.

2) MILD TO MODERATE ORAL TOXICITY: Patients with mild ingestions may only develop irritation or grade I (superficial hyperemia and edema) burns of the oropharynx, esophagus or stomach; acute or chronic complications are unlikely. Patients with moderate toxicity may develop grade II burns (superficial blisters, erosions and ulcerations) and are at risk for subsequent stricture formation, particularly esophageal. Some patients (particularly young children) may develop upper airway edema.

a) Alkaline corrosive ingestion may produce burns to the oropharynx, upper airway, esophagus and occasionally stomach. Spontaneous vomiting may occur. The absence of visible oral burns does NOT reliably exclude the presence of esophageal burns. The presence of stridor, vomiting, drooling, and abdominal pain are associated with serious esophageal injury in most cases.

b) PREDICTIVE: The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality.

3) SEVERE ORAL TOXICITY: May develop deep burns and necrosis of the gastrointestinal mucosa. Complications often include perforation (esophageal, gastric, rarely duodenal), fistula formation (tracheoesophageal, aortoesophageal), and gastrointestinal bleeding. Upper airway edema is common and often life threatening. Hypotension, tachycardia, tachypnea and, rarely, fever may develop. Stricture formation (esophageal, less often oral or gastric) is likely to develop long term. Esophageal carcinoma is another long term complication. Severe toxicity is generally limited to deliberate ingestions in adults in the US, because alkaline products available in the home are generally of low concentration.

4) INHALATION EXPOSURE: Mild exposure may cause cough and bronchospasm. Severe inhalation may cause upper airway edema and burns, stridor, and rarely acute lung injury.

5) OCULAR EXPOSURE: Ocular exposure can produce severe conjunctival irritation and chemosis, corneal epithelial defects, limbal ischemia, permanent visual loss and in severe cases perforation.

6) DERMAL EXPOSURE: Mild exposure causes irritation and partial thickness burns. Prolonged exposure or high concentration products can cause full thickness burns.


o A) WITH POISONING/EXPOSURE 1) Hypotension may occur after ingestion with corrosive injury and

hemorrhage from the gastrointestinal tract. 0.1.4 HEENT


27


1) Lacrimation, epistaxis, photophobia, blepharospasm, and brown discoloration of mucous membranes and the tongue may be noted.

0.1.5 CARDIOVASCULAR • 0.1.5.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) HYPOTENSION - Oral ingestion may result in shock secondary to corrosive

effects. 0.1.6 RESPIRATORY


1) Inhalation may cause severe irritation of the respiratory tract, cough, delayed pulmonary edema, bronchospasm, chemical pneumonitis, ARDS, glottal spasm, and glottal edema. Bromine is reported to be a more potent respiratory irritant than chlorine.

0.1.7 NEUROLOGIC • 0.1.7.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Headache and dizziness have been reported.


o A) WITH POISONING/EXPOSURE 1) Following ingestion mucosal burns, esophagitis, and gastroenteritis have

occurred. 2) Diarrhea, nausea, vomiting, and abdominal pain have been reported

following inhalation exposure. 0.1.10 GENITOURINARY


1) Hemorrhagic nephritis, with oliguria or anuria, may develop within 1 to 2 days after oral ingestion of liquid bromine, as a sequelae to shock or hemolysis.

0.1.14 DERMATOLOGIC • 0.1.14.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Dermatitis may occur following inhalation exposure. 2) Dermal burns may be noted.

0.1.21 CARCINOGENICITY • 0.1.21.1 IARC CATEGORY

o A) IARC Carcinogenicity Ratings for CAS7726-95-6 (IARC, 2004): 1) Not Listed

• 0.1.21.2 HUMAN OVERVIEW o A) No studies on the possible carcinogenic effects of bromine were found at the time

of this review. • 0.1.21.3 ANIMAL OVERVIEW

o A) No studies on the possible carcinogenic effects of bromine were found at the time of this review.

0.1.22 GENOTOXICITY

28


• A) No studies on the possible genetic effects of bromine were found at the time of this review.

G. Laboratory Test

• Obtain a complete blood count in symptomatic patients following bromine ingestion. • In patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or

adults with deliberate, high volume or high concentration ingestions), obtain renal function tests, serum electrolytes, INR, PTT, type and crossmatch for blood, and monitor urine output. Serum lactate and base deficit may also be useful in these patients.

• Monitor pulse oximetry or arterial blood gases in patients with signs and symptoms suggestive of upper airway edema or burns.

• Obtain an upright chest x-ray in patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or adults with deliberate, high volume or high concentration ingestions) to evaluate for pneumomediastinum or free air under the diaphragm. The absence of these findings DOES NOT rule out the possibility of necrosis or perforation of the esophagus or stomach. Obtain a chest radiograph in patients with pulmonary signs or symptoms.

• Several weeks after ingestion, barium contrast radiographs of the upper GI tract are useful in patients who sustained grade II or III burns, to evaluate for strictures.


• A) MANAGEMENT OF MILD TO MODERATE ORAL TOXICITY o 1) As there is little data on exposure to bromine, the following treatment information

is based on experience with other alkaline corrosive agents. Perform early (within 12 hours) endoscopy in patients with stridor, drooling, vomiting, significant oral burns, difficulty swallowing or abdominal pain, and in all patients with deliberate ingestion. If burns are absent or grade I severity, patient may be discharged when able to tolerate liquids and soft foods by mouth. If mild grade II burns, admit for intravenous fluids, slowly advance diet as tolerated. Perform barium swallow or repeat endoscopy several weeks after ingestion (sooner if difficulty swallowing) to evaluate for stricture formation.

• B) SEVERE ORAL TOXICITY o 1) Resuscitate with 0.9% saline; blood products may be necessary. Early airway

management in patients with upper airway edema or respiratory distress. Early (within 12 hours) gastrointestinal endoscopy to evaluate for burns. Early bronchoscopy in patients with respiratory distress or upper airway edema. Early surgical consultation for patients with severe grade II or grade III burns, large deliberate ingestions, or signs, symptoms or laboratory findings concerning for tissue necrosis or perforation.

• C) DILUTION o 1) Dilute with 4 to 8 ounces of water may be useful if it can be performed shortly

after ingestion in patients who are able to swallow, with no vomiting or respiratory distress; then the patient should be NPO until assessed for the need for endoscopy. Neutralization, activated charcoal, ipecac and gastric lavage are all contraindicated.

• D) AIRWAY MANAGEMENT

29


o 1) Aggressive airway management in patients with deliberate ingestions or any indication of upper airway injury.

• E) ENDOSCOPY o 1) Should be performed as soon as possible (preferably within 12 hours, not more

than 24 hours) in any patient with deliberate ingestion, adults with any signs or symptoms attributable to inadvertent ingestion, and in children with stridor, vomiting, or drooling after inadvertent ingestion. Endoscopy should also be considered in children with dysphagia or refusal to swallow, significant oral burns, or abdominal pain after unintentional ingestion. Children and adults who are asymptomatic after inadvertent ingestion do not require endoscopy. The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality. The absence of visible oral burns does NOT reliably exclude the presence of esophageal burns.

• F) CORTICOSTEROIDS o 1) The use of corticosteroids to prevent stricture formation is controversial.

Corticosteroids should not be used in patients with grade I or grade III injury, as there is no evidence that it is effective. Evidence for grade II burns is conflicting, and the risk of perforation and infection is increased with steroid use.

• G) STRICTURE o 1) A barium swallow or repeat endoscopy should be performed several weeks after

ingestion in any patient with grade II or III burns or with difficulty swallowing to evaluate for stricture formation. Recurrent dilation may be required. Some authors advocate early stent placement in these patients to prevent stricture formation.

• H) SURGICAL MANAGEMENT o 1) Immediate surgical consultation should be obtained on any patient with grade III

or severe grade II burns on endoscopy, significant abdominal pain, metabolic acidosis, hypotension, coagulopathy, or a history of large ingestion. Early laparotomy can identify tissue necrosis and impending or unrecognized perforation, early resection and repair in these patients is associated with improved outcome.

• I) PATIENT DISPOSITION o 1) OBSERVATION CRITERIA: Patients with alkaline corrosive ingestion should be sent

to a health care facility for evaluation. Patients who remain asymptomatic over 4 to 6 hours of observation, and those with endoscopic evaluation that demonstrates no burns or only minor grade I burns and who can tolerate oral intake can be discharged home.

o 2) ADMISSION CRITERIA: Symptomatic patients, and those with endoscopically demonstrated grade II or higher burns should be admitted. Patients with respiratory distress, grade III burns, acidosis, hemodynamic instability, gastrointestinal bleeding, or large ingestions should be admitted to an intensive care setting.

• J) PITFALLS o 1) The absence of oral burns does NOT reliably exclude the possibility of significant

esophageal burns. o 2) Patients may have severe tissue necrosis and impending perforation requiring

early surgical intervention without having severe hypotension, rigid abdomen, or radiographic evidence of intraperitoneal air.

o 3) Patients with any evidence of upper airway involvement require early airway management before airway edema progresses.

30


o 4) The extent of eye injury (degree of corneal opacification and perilimbal whitening) may not be apparent for 48 to 72 hours after the burn. All patients with corrosive eye injury should be evaluated by an ophthalmologist.

• K) DIFFERENTIAL DIAGNOSIS o 1) Acid ingestion, gastrointestinal hemorrhage, or perforated viscus.

0.1.3 INHALATION EXPOSURE • A) DECONTAMINATION

o 1) Administer oxygen as necessary. Monitor for respiratory distress. • B) AIRWAY MANAGEMENT

o 1) Manage airway aggressively in patients with significant respiratory distress, stridor or any evidence of upper airway edema. Monitor for hypoxia or respiratory distress.

• C) BRONCHOSPASM o 1) Treat with oxygen, inhaled beta agonists and consider systemic corticosteroids.

0.1.4 EYE EXPOSURE • A) DECONTAMINATION

o 1) Exposed eyes should be irrigated with copious amounts of 0.9% saline for at least 30 minutes, until pH is neutral and the cul de sacs are free of particulate material.

o 2) An eye examination should always be performed, including slit lamp examination. Ophthalmologic consultation should be obtained. Antibiotics and mydriatics may be indicated.


o 1) DECONTAMINATION a) Remove contaminated clothes and any particulate matter adherent to

skin. Irrigate exposed skin with copious amounts of water for at least 15 minutes or longer, depending on concentration, amount and duration of exposure to the chemical. A physician may need to examine the area if irritation or pain persist.

I. EMERGENCY ACTION GUIDELINES:

• Fire Fighting Procedure: o Use water spray to keep fire-exposed containers cool. Use appropriate extinguishing

agents on nearly combustible fires. o If material involved in fire: Extinguish fire using agent suitable for type of surrounding

fire. (Material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use water spray to knock-down vapors.

• Protective Equipment & Clothing: o Wear appropriate personal protective clothing to prevent skin contact. o Wear appropriate eye protection to prevent eye contact. o Eyewash fountains should be provided in areas where there is any possbility that

workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.

o Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities should provide a sufficient quantity or flow of water to quickly

31


remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.)

o Respirator Recommendations: Up to 2.5 ppm: (Assigned Protection Factor = 25) Any supplied-air respirator operated in a continuous-flow mode. Substance causes eye irritation or damage; eye protection needed./(Assigned Protection Factor = 25) Any powered, air-purifying respirator with cartridge(s) providing protection against the compound of concern. Only nonoxidizable sorbents allowed (not charcoal). Substance causes eye irritation or damage; eye protection needed.

o Respirator Recommendations: Up to 3 ppm: (Assigned Protection Factor = 50) Any chemical cartridge respirator with a full facepiece and cartridge(s) providing protection against the compound of concern. Only nonoxidizable sorbents allowed (not charcoal). Only nonoxidizable sorbents allowed (not charchoal)/(Assigned Protection Factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern. Only nonoxidizable sorbents allowed (not charcoal)./(Assigned Protection Factor = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and cartridge(s) providing protection against the compound of concern. Only nonoxidizable sorbents allowed (not charcoal). Substance causes eye irritation or damage; eye protection needed./(Assigned Protection Factor = 50) Any self-contained breathing apparatus with a full facepiece./(Assigned Protection Factor = 50) Any supplied-air respirator with a full facepiece.

o Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned Protection Factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode./(Assigned Protection Factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.

o Respirator Recommendations: Escape: (Assigned Protection Factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern. Only nonoxidizable sorbents allowed (not charcoal)/Any appropriate escape-type, self-contained breathing apparatus.

• Cleanup Method: o SMALL SPILLS: absorb with sand or other noncombustible absorbent material and place

in container Small spills (from a small package or a small leak form a large package): Isolate in all directions, 200 ft. Protect persons downwind, 0.2 miles /during the day/, 0.6 miles /at/ night. LARGE SPILLS: dike spill for later disposal Large spills (from a large package or from any small packages): Isolate in all directions, 700 ft. Protect persons downwind, 0.5 miles /during the/ day, 2.2 miles /at/ night.

o 1) ventilate area of spill or leak. 2) collect for reclamation or absorb in vermiculite, dry sand, earth, or a similar material or pour sodium thiosulfate or lime water over small spills.

32


o Soln or slurries of 10-50% potassium carbonate, 10-13% sodium carbonate, & 5-10% sodium bicarbonate or saturated "hypo" soln (prepared by dissolving 4 kg of technical-grade sodium thiosulfate in 9.5 l of water & adding 113 g of soda ash) are preferred neutralizing agents for liquid bromine spills.

o A 5% lime slurry or 5% sodium hydroxide soln may be used, but heats of reaction are higher for these reagents. Ammonia soln should not be applied to liquid spills because of the high heat of reaction & nitrogen evolution. Anhydrous ammonia gas is useful for neutralization of bromine fumes.

• Disposal Method: o SRP: The most favorable course of action is to use an alternative chemical product with

less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

• ERPG GUIDE: Please refer Emergency Response Guide No. 154 enclosed in Annexure-____ for detailed Emergency Actions

6. ACETIC ACID: A. General Details

• Synonyms: Acetic acid, glacial, Ethanoic Acid, Glacial Acetic Acid, Methanecarboxylic Acid, Pyroligneous acid, Vinegar acid, Vosol

• Molecular Formula: C2-H4-O2 • Molecular Weight: 60.05

B. NFPA Classification Health: 3 (Serious) Materials that, on short exposure, could cause serious temporary or residual injury, including those requiring protection from all bodily contact. Fire fighters may enter the area only if they are protected from all contact with the material. Full protective clothing, including self-contained breathing apparatus, coat, pants, gloves, boots, and bands around legs, arms, and waist, should be provided. No skin surface should be exposed. Flammability: 2 (Moderate) This degree includes materials that must be moderately heated before ignition will occur and includes Class II and IIIA combustible liquids and solids and semi-solids that readily give off ignitable vapors. Water spray may be used to extinguish fires in these materials because the

33


materials can be cooled below their flash points. Instability: 0 (Minimal) This degree includes materials that are normally stable, even under fire exposure conditions, and that do not react with water. Normal fire fighting procedures may be used.

C. Hazardous Property

• FLAMMABLE LIQUIDS – CORROSIVE o Flammable/combustible materials

• SUBSTANCES - TOXIC and/or CORROSIVE (Combustible) o TOXIC; inhalation, ingestion, or skin contact with material may cause severe

injury or death

D. Storage Condition • Store in a dry, well ventilated place. Separate from oxidizing materials and alkaline substances. • Fireproof. Separate from food and feedstuffs. Keep in a well-ventilated room. • Quantities greater than 1 liter should be stored in tightly sealed metal containers in areas

separate from oxidizers

E. Exposure Limits • IDLH:50 ppm • TLV: 8 hr Time Weighted Avg (TWA): 10 ppm; 15 min Short Term Exposure Limit (STEL): 15 ppm. • OSHA Standard: Permissible Exposure Limit: 8-hr Time Weighted Avg: 10 ppm (25 mg/cu m).


• 0.1.1.1 ACUTE EXPOSURE o A) USES: Household uses include toilet, metal and drain cleaners, rust remover, in

batteries, and as a primer for artificial nails. Used in clandestine methamphetamine labs (ie, hydrochloric and sulfuric acid). Industrial uses include: metal refining, plumbing, bleaching, engraving, plating, photography, disinfection, munitions, fertilizer manufacture, metal cleaning, and rust removal.

o B) TOXICOLOGY: Acids cause coagulation necrosis. Hydrogen ions desiccate epithelial cells, causing edema, erythema, tissue sloughing and necrosis, with formation of ulcers and eschars.

o C) EPIDEMIOLOGY: Inadvertent ingestions occur with moderate frequency in children, and are less common than alkaline exposures. Serious exposures are rare in the developed world (generally only seen with deliberate ingestions), largely because only low concentration acids are available in the home. Serious effects are more common in developing countries.

o D) WITH POISONING/EXPOSURE

34


1) MILD TO MODERATE ORAL TOXICITY: Patients with mild ingestions may only develop irritation or Grade I (superficial hyperemia and edema) burns of the oropharynx, esophagus or stomach; acute or chronic complications are unlikely. Patients with moderate toxicity may develop Grade II burns (superficial blisters, erosions and ulcerations) are at risk for subsequent stricture formation, particularly gastric outlet and esophageal. Some patients (particularly young children) may develop upper airway edema.

2) SEVERE ORAL TOXICITY: May develop deep burns and necrosis of the gastrointestinal mucosa. Complications often include perforation (esophageal, gastric, rarely duodenal), fistula formation (tracheoesophageal, aortoesophageal), and gastrointestinal bleeding. Upper airway edema is common and often life threatening. Hypotension, tachycardia, tachypnea and, rarely, fever may develop. Other rare complications include metabolic acidosis, hemolysis, renal failure, disseminated intravascular coagulation, elevated liver enzymes, and cardiovascular collapse. Stricture formation (primarily gastric outlet and esophageal, less often oral) is likely to develop long term. Esophageal carcinoma is another long term complication. Severe toxicity is generally limited to deliberate ingestions in adults in the US, because acidic products available in the home are generally of low concentration.

a) PREDICTIVE: The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality. Initial signs and symptoms may not reliably predict the extent of GI burns.

3) INHALATION EXPOSURE: Mild exposure may cause dyspnea, pleuritic chest pain, cough and bronchospasm. Severe inhalation may cause upper airway edema and burns, hypoxia, stridor, pneumonitis, tracheobronchitis, and rarely acute lung injury or persistent pulmonary function abnormalities. Pulmonary dysfunction similar to asthma has been reported.

4) OCULAR EXPOSURE: Ocular exposure can produce severe conjunctival irritation and chemosis, corneal epithelial defects, limbal ischemia, permanent vision loss and in severe cases perforation.

5) DERMAL EXPOSURE: A minor exposure can cause irritation and partial thickness burns. More prolonged or a high concentration exposure can cause full thickness burns. Complications may include cellulitis, sepsis, contractures, osteomyelitis, and systemic toxicity.


o A) WITH POISONING/EXPOSURE 1) Shortness of breath may develop following inhalation of acid vapors, mists or

aerosols. 0.1.4 HEENT

35



1) Eye exposure may result in pain, swelling, corneal erosions and blindness. 0.1.5 CARDIOVASCULAR


1) Cardiovascular collapse may develop soon after severe poisonings. 0.1.6 RESPIRATORY


1) Inhalation may produce dyspnea, pleuritic chest pain, upper airway edema, pulmonary edema, hypoxemia, bronchospasm, pneumonitis, and persistent pulmonary function abnormalities. Airway hyperreactivity has also been reported.

a) The onset of respiratory symptoms may be delayed for several hours. 2) Life threatening upper airway obstruction may develop after ingestion of

concentrated acid. 0.1.7 NEUROLOGIC


1) Abnormal neuropsychologic function has been reported following hydrochloric acid exposure from a leaking tanker truck.


o A) WITH POISONING/EXPOSURE 1) Ingestion of acids may result in burns, gastrointestinal bleeding, gastritis,

perforations, dilation, edema, necrosis, vomiting, stenosis, fistula, and duodenal/jejunal injury.

0.1.9 HEPATIC • 0.1.9.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Systemic toxicity may result in acute hepatic injury. Hepatic injury has been

reported following chronic exposure to chromic acid. 0.1.10 GENITOURINARY


1) Renal failure is a rare complication of severe poisonings. Hemoglobinuria may develop secondary to hemolysis. Nephritis may develop after hydrochloric acid ingestion.


36


o A) WITH POISONING/EXPOSURE 1) Metabolic acidosis may develop following significant acid ingestion.

0.1.12 FLUID-ELECTROLYTE • 0.1.12.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Massive fluid and electrolyte shifts may occur with extensive dermal or

gastrointestinal burns. Hyperkalemia may occur with hemolysis. Hyperphosphatemia, hypocalcemia and hyperchloremia have been reported.

0.1.13 HEMATOLOGIC • 0.1.13.1 ACUTE EXPOSURE

o A) WITH POISONING/EXPOSURE 1) Hemolysis may occur following significant acid ingestion. Disseminated

intravascular coagulation has been reported. 0.1.14 DERMATOLOGIC


1) Chemical burns to the skin are often associated with concurrent thermal burns and trauma. Complications seen with thermal burns including cellulitis, sepsis, contractures, osteomyelitis, may occur as well as systemic toxicity from absorbed acid. Deep or extensive burns may require grafting.

2) Alopecia was reported following application of an acidic formulation of a hair-relaxing product.

3) Arterial injection of hydrochloric acid into the right inguinal area resulted in ischemia and ecchymosis of the right lower extremity as well as severe necrosis of the muscles.

• 0.1.14.2 CHRONIC EXPOSURE o A) Prolonged or repeated exposure to chromic acid mist can result in dermatitis.

Ulcerations may also occur. 0.1.20 REPRODUCTIVE HAZARDS

• A) Single doses of dibromoacetic acid has resulted in reductions of sperm and serum testosterone in experimental animals. Repeated or single oral administration of monobromoacetic acid did not produce effects on male rat reproductive organs or sperm.

G. Laboratory Test • Obtain a complete blood count and electrolytes in all patients with significant burns after

acid ingestion. • In patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or

adults with deliberate, high volume or high concentration ingestions), obtain renal function tests, liver enzymes, serial CBC, INR, PT, PTT, fibrinogen, fibrin degradation products, type and crossmatch for blood, and monitor urine output and urinalysis. Serum lactate and base deficit may also be useful in these patients.

37


• Monitor pulse oximetry or arterial blood gases in patients with signs and symptoms suggestive of upper airway edema or burns.

• Obtain an upright chest x-ray in patients with signs and symptoms suggesting severe burns, perforation, or bleeding (or adults with deliberate, high volume or high concentration ingestions) to evaluate for pneumomediastinum or free air under the diaphragm. The absence of these findings DOES NOT rule out the possibility of necrosis or perforation of the esophagus or stomach. Obtain a chest radiograph in patients with pulmonary signs or symptoms.

• Several weeks after ingestion, barium contrast radiographs of the upper GI tract are useful in patients who sustained grade 2 or 3 burns, to evaluate for strictures.


• A) DILUTION o 1) Dilute with 4 to 8 ounces of water may be useful if it can be performed shortly after

ingestion in patients who are able to swallow, with no vomiting or respiratory distress; then the patient should be NPO until assessed for the need for endoscopy. Neutralization, activated charcoal, ipecac and gastric lavage are all contraindicated.

• B) MILD TO MODERATE ORAL TOXICITY o 1) Within the first 12 hours of exposure, if burns are absent or grade I severity, patient

may be discharged when able to tolerate liquids and soft foods by mouth. If mild grade II burns, admit for intravenous fluids, slowly advance diet as tolerated. Perform barium swallow or repeat endoscopy several weeks after ingestion (sooner if difficulty swallowing) to evaluate for stricture formation.

• C) SEVERE ORAL TOXICITY o 1) Resuscitate with 0.9% saline; blood products may be necessary. Early airway

management in patients with upper airway edema or respiratory distress. Early (within 12 hours) gastrointestinal endoscopy to evaluate for burns. Early bronchoscopy in patients with respiratory distress or upper airway edema. Early surgical consultation for patients with severe grade II or grade III burns, large deliberate ingestions, or signs, symptoms or laboratory findings concerning for tissue necrosis or perforation.

• D) ENDOSCOPY o 1) Should be performed as soon as possible (preferably within 12 hours, not more than

24 hours) in any patient with acid ingestion. The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality. The absence of visible oral burns does NOT reliably exclude the presence of esophageal burns.

• E) AIRWAY MANAGEMENT o 1) Aggressive airway management in patients with deliberate ingestions or any

indication of upper airway injury. Severe edema may make intubation difficult; be

38


prepared for surgical airway management (cricothyroidotomy) in patients with severe upper airway edema.

• F) BRONCHOSPASM o 1) Treat with oxygen, inhaled beta agonists and consider systemic corticosteroids

• G) CORTICOSTEROIDS o 1) The use of corticosteroids to prevent stricture formation is controversial.

Corticosteroids should not be used in patients with grade I or grade III injury, as there is no evidence that it is effective. Evidence for grade II burns is conflicting, and the risk of perforation and infection is increased with steroid use, so routine use is not recommended.

• H) STRICTURE o 1) A barium swallow or repeat endoscopy should be performed several weeks after

ingestion in any patient with grade II or III burns or with difficulty swallowing to evaluate for stricture formation. Recurrent dilation may be required. Some authors advocate early stent placement in these patients to prevent stricture formation.

• I) SURGICAL MANAGEMENT o 1) Immediate surgical consultation should be obtained on any patient with grade III or

severe grade II burns on endoscopy, significant abdominal pain, metabolic acidosis, hypotension, coagulopathy, or a history of large ingestion. Early laparotomy can identify tissue necrosis and impending or unrecognized perforation, early resection and repair in these patients is associated with improved outcome.

• J) PATIENT DISPOSITION o 1) OBSERVATION CRITERIA: Patients with an acid ingestion should be sent to a health

care facility for evaluation. Patients with an endoscopic evaluation that demonstrates no burns or only minor grade I burns and who can tolerate oral intake can be discharged to home.

o 2) ADMISSION CRITERIA: Symptomatic patients, and those with endoscopically demonstrated grade II or higher burns should be admitted. Patients with respiratory distress, grade III burns, or extensive grade II burns, acidosis, hemodynamic instability, gastrointestinal bleeding, or large ingestions should be admitted to an intensive care setting.

• K) PITFALLS o 1) The absence of oral burns does NOT reliably exclude the possibility of significant

esophageal burns. o 2) Patients may have severe tissue necrosis and impending perforation requiring early

surgical intervention without having severe hypotension, rigid abdomen, or radiographic evidence of intraperitoneal air.

o 3) Patients with any evidence of upper airway involvement require early airway management before airway edema progresses.

39


o 4) The extent of eye injury (degree of corneal opacification and perilimbal whitening) may not be apparent for 48 to 72 hours after the burn. All patients with acidic eye injury should be evaluated by an ophthalmologist.

• L) DIFFERENTIAL DIAGNOSIS o 1) Alkaline corrosive ingestion, gastrointestinal hemorrhage, or perforated viscus.

0.1.3 INHALATION EXPOSURE • A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty

breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.

• B) INHALATION: Administer oxygen. If respiratory symptoms develop obtain chest x-ray, monitor pulse oximetry and/or blood gases. Treat bronchospasm with inhaled beta agonists. If acute lung injury develops, consider PEEP. Evaluate for esophageal, dermal and eye burns as indicated.

0.1.4 EYE EXPOSURE • A) DECONTAMINATION: Irrigate exposed eyes with copious amounts of room temperature

water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

• B) MEDICAL FACILITY: Irrigate with sterile 0.9% saline for at least an hour or until the cul-de-sacs are free of particulate matter and returned to neutrality (confirm with pH paper).

• C) EYE ASSESSMENT: The extent of eye injury (degree of corneal opacification and perilimbal whitening) may not be apparent for 48 to 72 hours after the burn.


o 1) DECONTAMINATION: Remove contaminated clothing and jewelry; wash exposed area with copious amounts of water. A physician may need to examine the area if irritation or pain persists.


o Use water spray, dry chemical, "alcohol" foam, or carbon dioxide. Use water to keep fire-exposed containers cool.

o /When fighting fire/ use self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.

o If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors.

o Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. /Corrosive liquid/

40


• Protective Equipment & Clothing: o Persons working with pure acid or concentrated solution should wear protective

clothing, eye and face, ...hand and arm protection, and respiratory equipment. o 500 ppm: Chemical cartridge respirator with an organic vapor cartridge(s) with a

full facepiece or gas mask with an organic vapor canister (chin-style or front- or back-mounted canister) or supplied-air respirator with a full facepiece, helmet, or hood, or self-contained breathing apparatus with a full facepiece. 1000 ppm: Type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous-flow mode. Escape: Gas mask with an organic vapor canister (chin-style or front- or back-mounted canister) self-contained breathing apparatus.

o Breakthrough times of greater than one hour were reported by (normally) two or more testers for neoprene, nitrile rubber, polyethylene, polyvinyl chloride, natural rubber and Vitron.

o Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with solid or liquid acetic acid or solutions containing 50% or more of acetic acid by weight and to prevent repeated or prolonged skin contact with solutions containing 10% or more but less than 50% of acetic acid by weight.

o Employees should be provided with and required to use dust- and splash-proof safety goggles where there is any possibility of solid or liquid acetic acid or solutions containing acetic acid contacting the eyes.

o Wear appropriate personal protective clothing to prevent skin contact. />10%/ o Wear appropriate eye protection to prevent eye contact. o Eyewash fountains should be provided in areas where there is any possbility that

workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. />5%/

o Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] />50%/

o Respirator Recommendations: Up to 50 ppm: (Assigned protection factor = 25) Any supplied-air respirator operated in a continuous-flow mode. Substance causes eye irritation or damage; eye protection needed./(Assigned protection factor = 25) Any powered, air-purifying respirator with organic vapor cartridge(s). Substance causes eye irritation or damage; eye protection needed./(Assigned protection factor = 50)

41


Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)/(Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/(Assigned protection factor = 50) Any self-contained breathing apparatus with a full facepiece/(Assigned protection factor = 50) Any supplied-air respirator with a full facepiece.

o Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned protection factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode/(Assigned protection factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus.

o Respirator Recommendations: Escape: (Assigned protection factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister/Any appropriate escape-type, self-contained breathing apparatus.

• Cleanup Method:

o Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with caustic soda or soda ash.

o Environmental considerations: Water spill: Add dilute caustic soda o Environmental considerations: Air spill: Apply water spray or mist to knock down

vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.

o Collect leaking liquid in sealable containers. Cautiously neutralize spilled liquid with sodium carbonate only under the responsibility of an expert. Wash away remainder with plenty of water (extra personal protection: chemical protection suit including self-contained breathing apparatus).

o Remove all ignition sources, ventilate area of spill or leak. If in liquid form, for small quantities, absorb on paper towels ... large quantities can be collected & atomized in suitable combustion chamber, or diluted ... neutralized & flushed into a sewer. If in the solid form, collect in the most safe & convenient manner for reclamation or allow to melt & collect as above.

o Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Use soda ash to neutralize spills. Control runoff and isolate discharged material for proper. disposal.

42



o SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

o Excess acetic acid and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

o The following wastewater treatment technologies have been investigated for acetic acid: Activated carbon.

o The following wastewater treatment technologies have been investigated for acetic acid: Reverse osmosis.

• ERPG GUIDE.: Please refer Emergency Response Guide No. 132 & 153 enclosed in Annexure-VII(A) for detailed Emergency Actions.

43

Adequacy Report

Annexure- VIII

Treatability / Feasibility Report

for

Proposed Waste Water Generation and its

Treatment Scheme

&

Adequacy of Existing Waste Water

Treatment Facilities

for

M/s. HENI DRUGS PVT. LTD.

Unit Located at: Plot No. 1901/1901A, Phansa Char Rasta, GIDC, Sarigam- 396155, Tal. Umbergaon,

Dist.: Valsad (Gujarat)

Prepared By:

M/s. UniStar Environment and Research Labs Pvt. Ltd. White House, Near G.I.D.C. office, Char Rasta, Vapi-396195. Dist.-Valsad, Tel.: (0260) 2433966, 2435610 e-mail: [email protected]

mailto:[email protected]

UERL/TER/006/03/2016 UNISTAR ENVIRONMENT & RESEARCH LABS PVT. LTD.

Page | 1

INTRODUCTION:

M/s. Heni Drugs Pvt. Ltd. has set up a manufacturing unit located at Plot no. 1901/1901A,

Phansa Char Rasta, GIDC, Sarigam - 396155, Tal. Umbergaon, Dist.: Valsad. The unit is

manufacturing Metal Salt and Ethyl Oleate by Continuous distillation of crude with having

valid CCA of the Board.

Now as per the information provided to us the unit proposes to increase production

quantity of existing products and also introduce new products. Detailed breakup of the

existing, proposed and total after expansion production capacity are as under.

Sr. No.

Products Name Production Capacity (MT/year)

Existing Proposed Total

1. Ethyl Oleate by Continuous distillation of crude

300.00 00.00 300.00

2. Metal salt of copper, cobalt, Nickel, Bismuth, Mercury and Aluminum Magnesium Mix Hydrotalcite salt

900.00 00.00 900.00

3. Esters

(Ethyl Oleate / Ethyl Lactate., Benzyl Cinnamte / Salicylate , Geranyl Acetate / Formate, Phenoxy Ethyl Isobutyrate / Isovaleriate, Vetiveryl Acetate, Ethy hexyl oleate, Cholesterol oleate Benzyl benzoate, Glycidyl Ester (E10), Dibasic esters, and similar ...)

00.00 250.00 250.00

4. Organics Intermediates

((3H)-Isobenzofuranone,3,3-bis(4-hydroxyphenyl) (IBFH) , Tetra bromo -(3H)-Isobenzofuranone,3,3-bis (4hydroxyphenyl) , N,N dimethyl amino acrylate(1,3-epoxy-2-propanone , and similar ...)

00.00 45.00 45.00

5. Aromatic Metal Compounds

a. Phenyl mercuric acetate

b. Phenyl mercuric nitrate

c. Phenyl mercuric oleate

d. Phenyl mercury dodecenyl succinate

00.00 100.00 100.00

6. Extracts and Oils

(Cardamom Oli, Spearmint Oil, Eucalyptus Oil

Mentha Oil, Citronella Oil, Geranium Oil Pink Pepper Oil, Vetiveryl Oil, Rose Crystals, and similar ...)

00.00 20.00 20.00

TOTAL 1200.00 415.00 1615.00


Page | 2

As per the information obtained from the unit:

Existing product Metal Salt is inorganic product, manufactured by simple inorganic

chemical reaction.

Existing Product Ethyl Oleate is manufacture by continuous distillation of crude Ethyl

Oleate.

Proposed product Esters will be manufacture by Esterification of Fatty Acid /

Vegetable Oil with Alcohol.

Proposed product Organics Intermediates will be manufactured by standard

reactions like condensation, addition and purification.

Proposed product Aromatic Metal Compounds will be manufactured by chemical

reaction with Aromatic Compound with Mercury salt.

Proposed product Extracts and Oils will be manufactured by only extraction and

decantation unit operation. No chemical reaction involved.

Water Pollution Potential for manufacturing of proposed products :

Water Requirement

Sr. No. Water Consumption Quantity in KL/day

Exiting Proposed Total after expansion

1 Domestic 2.00 2.00 4.00

2 Industrial

Process & Washing 1.00 6.00 7.00

Boiler 1.00 9.00 10.00

Cooling 2.00 8.00 10.00

Subtotal Industrial 4.00 23.00 27.00

3 Gardening 1.00 1.00 2.00

Total 7.00 26.00 33.00

Wastewater Generation

The category wise bifurcation of the wastewater generation after proposed product is given

below in Table.

Sr. No. Waste Water Generation

Quantity in KL/day

Exiting Proposed Total after expansion

1 Domestic 1.80 1.70 3.50

2 Industrial

Process & Washing 0.90 6.10 7.00

Boiler 0.05 0.05 0.10

Cooling 0.05 0.05 0.10

Subtotal Industrial 1.00 6.20 7.20

Total 2.80 7.90 10.70


Page | 3

Existing waste water is generated from ancillary activities like process, washing of

equipments, floor and utilities.

Waste water generated during existing product is being treated in the adequately

designed existing ETP and treated waste water is being evaporated in evaporator.

Proposed waste water generated from ancillary activities like process, washing of

equipments, floor and utilities will be treated in proposed effluent treatment plant.

Details of existing and proposed waste water treatment are enclosed as Annexure-I.

Detailed water balance diagram after proposed expansion is as under.


Page | 4

Treatability for Waste water Treatment :

Stream wise Waste Water Generation per day : based on the production capacity, water

requirement and mass balance of product the per day waste water requirement is

worked out as under :

Stream Product Name Waste water generation in kL/d

Stream - I Ethyl Oleate by Continuous distillation of crude ethyl Oleate (Existing Product).

0.00

Stream - II Metal salt of copper, cobalt, Nickel, Bismuth, Mercury and Aluminum Magnesium Mix Hydrotalcite salt (Existing Product)

0.90

Stream – III Esters

(Ethyl Oleate / Ethyl Lactate., Benzyl Cinnamte / Salicylate , Geranyl Acetate / Formate, Phenoxy Ethyl Isobutyrate / Isovaleriate, Vetiveryl Acetate, Ethy hexyl oleate, Cholesterol oleate Benzyl benzoate, Glycidyl Ester (E10), Dibasic esters ,etc..)

1.10

Stream – IV Organics Intermediates

((3H)-Isobenzofuranone,3,3-bis(4-hydroxyphenyl) (IBFH) , Tetra bromo –(3H)-Isobenzofuranone,3,3-bis (4hydroxyphenyl) , N, N dimethyl amino acrylate (1,3-epoxy-2-propanone ,etc..)

1.65

Stream – V

Aromatic Metal Compounds

e. Phenyl mercuric acetate

f. Phenyl mercuric nitrate

g. Phenyl mercuric oleate

h. Phenyl mercury dodecenyl succinate

1.85

Stream – VI Extracts and Oils

(Cardamom Oil, Spearmint Oil, Eucalyptus Oil

Mentha Oil, Citronella Oil, Geranium Oil Pink Pepper Oil, Vetiveryl Oil, Rose Crystals, etc…)

1.5

Stream – VII Boiler and Cooling activity 0.20

TOTAL 7.20


Page | 5

Stream wise characteristics of waste water stream are given in below tables:

Characteristics of Waste water stream:

1. Stream – II: (Existing Product)

Sr. No. Test Parameters Unit Results

1. pH -- 3.2

2. Colour (Pt- Co Scale unit) -- 200

3. Total Suspended Solids mg/lit 194

4. COD Value mg/lit 86

5. BOD Value (3 days at 27o c) mg/lit <5

6. Oil & Grease mg/lit <1

7. Mercury mg/lit 0.81

8. Other Heavy Metals mg/lit 2.85

2. Stream – III :


1. pH -- 5.4




5. BOD Value (3 days at 27o c) mg/lit 6895

6. Oil & Grease mg/lit 35

7. Phenolic compound mg/lit < 0.1

8. Ammonical Nitrogen mg/lit < 5.0

3. Stream – IV:


1. pH -- 7.8






7. Phenolic compound mg/lit 2.35



Page | 6

4. Stream – V:


1. pH -- 6.8






7. Phenolic compound mg/lit 0.85


9. Mercury mg/lit 1.05

5. Stream – VI:


1. pH -- 6.8






7. Phenolic compound mg/lit < 0.1


6. Stream – VII :


1. pH -- 6.8







Page | 7

Stream no. II and Stream no. V (quantity : 2.75 kL/day) contains heavy metals which

require separate metal removal treatment as under :

Metal Removal treatment :

The composite waste water was taken and pH of the same increased up to 12 by

addition of lime solution and the generated Metal Hydroxides were filtered out. The

clear alkaline solution was neutralized with Alum solution and again the coagulated

mass was filtered out. Clear neutral waste water was passed through activated charcoal

tube and taken for analysis. During this treatment all the heavy metal as well as

Mercury are removed (Ref. International Journal of Chemical, Molecular, Nuclear,

Materials and Metallurgical Engineering Vol:6, No:12, 2012).

The mercury containing effluent from the process is collected separately inside the

plant. The mercury is eliminated from that stream by passing through an electrolyte

batch and activated carbon. The mercury free waste stream is then sent to the ETP.

Analytical test results before Metal removal and after metal removal effluent are as under:

Sr.

No.

Parameters Unit I II

1. pH -- 5.62 7.4

2. Colour (Pt- Co Scale unit) -- 150 50

3. Total Suspended Solids mg/lit 126 54

4. COD Value mg/lit 604 385

5. BOD Value (3 days at 27o c) mg/lit 128 89

6. Oil & Grease mg/lit 6.0 < 4.00

7. Mercury mg/lit 0.97 < 0.01

8. Phenolic compound mg/lit 0.57 < 0.1

9. Ammonical Nitrogen mg/lit 3.36 < 5.0

10. Heavy Metals mg/lit 0.93 < 0.01

I : Untreated (composite of Stream II & V), II : After Metal Removal Treatment Outlet

As can be observed from the above analytical results that all the heavy metals and Phenolic compounds are remove from the effluent and are well within the prescribed norms in treated waste water. The other parameters like COD value, BOD value, and suspended solids need further treatment. Hence this treated waste water was mixed with the other steam as per required proportion waste water for further treatment as under. The generated solid waste and activated carbon waste shall be disposed through approved TSDF site with required treatment.


Page | 8

7. Composite stream: (Stream – III, IV, VI, VII and stream II & V after metal removal treatment) Initially Untreated Composite Effluent sample was analyzed for relevant parameters and was taken for the treatability study.


1. pH -- 9.8






7. Mercury mg/lit < 0.01

8. Phenolic compound mg/lit <0.1


10. Heavy Metal mg/lit <0.01

So, in order to decide waste water treatment scheme for proposed products, untreated

composite effluent sample was used to work out the Treatability Study.

As can be observed from above analysis results that the sample needs treatment for

some relevant parameters like Suspended Solids, COD, and BOD. Hence the study has

been carried out as follows to achieve the treated waste water norms laid down by

G.P.C.B.

1. PRIMARY TREATMENT:

The effluent was taken and neutralized by non ferric alum. Polyelectrolyte (coagulant) is

added for proper settling of flocks to reduce the suspended solid concentration, color and

COD in the effluent. Neutral effluent filtered through the filter paper and the clear effluent

was analyzed and the results of the same are as bellow.

Analysis Report after primary treatment:

Sr. No. Test Parameters Unit Results % reduction

1. pH -- 7.2 --

2. Colour (Pt- Co Scale unit) -- 80 --




6. Oil & Grease mg/lit 8.0 --

7. Mercury mg/lit < 0.01 --

8. Phenolic compound mg/lit <0.1 --

9. Ammonical Nitrogen mg/lit < 5.0 --

10. Heavy Metal mg/lit <0.01 --


Page | 9

As can be observed from above results, almost all the parameters except COD & BOD are

observed well within the treated effluent norms laid down by GPCB for disposal. For the

removal of COD & BOD, the primary treated effluent was given the Secondary treatment

(Biological treatment) as follows:

2. SECONDARY TREATMENT (Biological Treatment):

The bench scale experimentation was carried out with 750 ml. of Primary Treated Effluent

which is treated with 250 ml. of biomass. It was initially analyzed for COD & BOD value and

then two stage aeration was started through laboratory scale with Spurger type aerator.

Required quantity of Nitrogen & Phosphorus (From Urea / DAP) as nutrient were added and

COD values were checked after 48 hours.

Sr.

No.

Test Parameters Unit

Results

% reduction

1. COD Value mg/lit 128 96 %

2. BOD Value ( 3 days at 27o c) mg/lit 36 97 %

As can be observed from the above results, more than 90 % reduction in COD Value and

more than 95 % reduction in BOD value could be achieved through biological treatment.

3. TERTIARY TREATMENT:

After secondary treatment clear effluent was passed through Sand column and Activated

Carbon column. And outlet effluent was analyzed as follows.

Sr. No. Test Parameters Unit Results % reduction

1. pH -- 7.1 --

2. Colour (Pt- Co Scale unit) -- 50 --




6. Oil & Grease mg/lit Nil --

7. Mercury mg/lit < 0.002 --

8. Phenolic compound mg/lit < 0.1 --

9. Ammonical Nitrogen mg/lit < 5.0 --

10. Heavy Metal mg/lit <0.01 --

As can be observed from above results, almost all the parameters are observed well

within the treated effluent disposal norms laid down by G.P.C.B.


Page | 10

Based on above results and capacity of installed ETP units the design criteria and

Adequacy of ETP is as under:

Design Criteria of ETP and its Adequacy

Source of Effluent: Process, Washing and utilities.

Effluent treatment capacity: 10 kL/day Max.

Sr. No.

Parameter Untreated Effluent (Inlet)

Treated Effluent (Outlet)

1 pH 5 to 10 5.5 to 8.5

2. Colour[Hazen Unit(APHA)] 200 (max) <100

3. Suspended Solids (mg/lit) 200 (max) <100

4. Chemical Oxygen Demand (mg/lit) 5500 (max) <250

5. Biochemical Oxygen Demand (mg/lit) 2500 (max) <30

6. Oil & Grease (mg/lit) 20 (max) <10

Based on the above criteria and effluent quantity, Effluent Treatment Plant having following units with mentioned required specifications and capacity is to be installed.

List of the ETP units with MOC to be design, erected and commissioned :

Sr. No.

Unit No. of Unit

Capacity Retention Time

Remarks

1. Oil & Grease Trap 02 0.5 KL each -- Adequate

2. Collection Tank 01 11.0 KL 1 day Adequate

3. Primary settling Tank 01 4.0 KL 8 hours Adequate

4. Aeration Tank 01 35.0 KL 3 days F/M= 0.2, MLVSS= 3000

mg/Liter, required

volume= 33.3 m3. So more

than adequate

5. Secondary Settling Tank 01 4.0 KL 8 hours Adequate

6. Holding Tank 01 6.0 KL 10 hours Adequate

7. Pressure Sand Filter 01 1.0 kL/hr -- Adequate

8. Activated Carbon Filter 01 1.0 kL/hr -- Adequate

9. Treated water Tank 01 6.0 kL -- Adequate

10. Sludge Drying Beds 03 2.0 m2 each -- Adequate

11. Sludge Storage Area 01 4.0 m2 -- Adequate


Page | 11

7. Adequacy for Existing Effluent Treatment Plant:

Sr. No.

Unit No. of Unit

Capacity Retention Time

Remarks

1. Collection Tank 01 3.0 KL 1 day Adequate

2. Primary settling Tank 01 0.5 KL 4 hours Adequate

3. Holding Tank 01 1.0 KL 7 hours Adequate

4. Pressure Sand Filter 01 0.15 kL/hr -- Adequate

5. Activated Carbon Filter 01 0.15 kL/hr -- Adequate

6. Treated water Tank 01 2.0 kL -- Adequate

7. Evaporator 01 0.5 kL/hr -- Adequate

8. Filter Neutch 03 1.5 m2 each -- Adequate

9. Sludge Storage Area 01 1.0 m2 -- Adequate

The effluent coming from stream – II and stream – V will be treated in adequate existing effluent treatment plant.

CONCLUSIVE REMARKS :

It is concluded that the Environment Management System provided by M/s. Heni Drugs Pvt.

Ltd. is adequate and efficient to comply the norms for the manufacturing of existing product

as well as propose products within the existing infrastructure.

Recommendations:

a. To maintain good housekeeping and environmental conditions by adopting good

manufacturing process.

b. To develop more greenbelt surrounding the unit to reduce probable minor impacts

of industrial activities.

For UNISTAR ENVIRONMENT AND RESEARCH LABS PRIVATE LIMITED Jaivik S. Tandel (Environmental Auditor)


Page | 12

ANNAXTURE – I PROPOSSED EFFLUENT TREATMENT SCHEME

1. PRIMARY TREATMENT: UNITS: Oil & Grease removal Tank

Collection cum Neutralization Tank

Primary settling and sludge removal

The effluent coming from the proposed plant and from the existing effluent treatment

plant is initially passed through the Oil & Grease removal system. The oil free effluent is

then collected into the collection cum reaction tank. In the collection cum reaction tank

various chemicals like None Ferric Alum, Caustic soda/acid and polyelectrolyte

(coagulant) are added to ensure proper settling which reduces the suspended solid

concentration, color and COD in the effluent. The treated effluent is then fed into the

primary clarifier. Clear effluent from primary settling tank is charged into the secondary

treatment tank (Aeration tank) and settled sludge is discharged into the sludge drying

beds and leached of the sludge drying beds is going back to collection tank.

2. SECONDARY TREATMENT (BIOLOGICAL TREATMENT):

UNITS: Aeration Tank

Secondary settling

The primary treated clear effluent is passed through the aeration tank where the

biodegradation of the organic matter is taken place in presence of active microorganism

and required Dissolved Oxygen level. During the biological treatment BOD Value and COD

Value are reduced. After the biological treatment (aeration tank) the effluent with the

biomass is passed through secondary settling tank where biomass is settled and settled

biomass is recycle back to aeration tank or if excess is discharged into the sludge drying

beds. And clear effluent is collected into the holding tank.

3. TERTIARY TREATMENT:

UNIT: Sand and Carbon Filter (Mixed bed)

After secondary treatment the effluent is passed through the mixed bed filter for further

reduction of COD Value, BOD Value and Color. Treated water is collected into the treated

water tank above the roof. Finally the treated effluent confirming the treated water

discharge norms laid down by board will be discharged for plantation or into the closed

drainage line.


Page | 13


Page | 14

FLOW DIAGRAM OF EXISTING EFFLUENT TREATMENT PLANT

CSR activity details

Annexure- IX

M/s. Heni Drugs pvt.ltd

The proposed CSR programs are based on the needs felt and socioeconomic indicators of the study. The proposed CSR programs can be initially implemented in the five villages of the study area. Based on the outcome of the CSR programs, it will be expanded to the other villages apart from the study area. According to our survey output and social need base we have recommended various CSR activities. A budget of Rs. 8 Lacs (2 % of the total cost) have been provided for the next 5 years to carry out various CSR activities in nearby area of Sarigam GIDC Area as detailed in EIA report. A budget of Rs. 1.60 lakhs have been allocated for every year to carry out various CSR activities.

The CSR Policy of M/s. Heni Drugs Pvt. Ltd aims at strengthening the bond between the project/ authorities and local population in the vicinity of proposed project. In Line with this CSR Policy. Project proponents will be carried out number of Community Welfare activities in following Areas. CSR Project proposal

A. Education:

Unit will take part in some children development programs and contribute some funds by

distributing school kits (school bags, books, note books, etc.) to nearby schools.

1. Improve the level of literacy at primary, secondary and advanced levels of education by providing scholarships to the meritorious students, enhancing school infrastructural facilities, industrial training, etc.

2. Residential Bridge Course for drop out students through free coaching classes for students belonging to economically weak background.

3. Scholarships/fellowships to deserving students to encourage education.

4. Provision of uniforms, books, and stationery, necessary equipments etc, to schools.

5. Promote computer literacy and technology assisted learning.

6. Skill Development for sustainable income generation & Livelihood for women.

7. Vocational training for Youth & Women.

B. Health :

1. Offering specialized support services to the physically handicapped and mentally

challenged people.

2. Preventive health care by organizing health camps for immunization through vaccination

3. Curative health care by conducting specific health camps such as eye care for

cataract, glaucoma, etc.


4. Support the health units/hospitals in the region by proving infrastructural facilities

5. Reproductive and child health through conducting awareness camps in the region

C. Water and Sanitation:

1. Safe drinking water provides by water tanker during water crises circumstances.

2. Build water storage structures incorporate with government.

3. Sanitation facility provides by building common toilets if needed possible

extended to street wise.

4. Infrastructure development through providing drinking water facilities in the

villages of the region.

D. Women Development activities

1. Unit may also organize some women development programs like stitching,

cooking, knitting, handicraft, etc. to develop skill of women which will be helpful

to them for self-sustainable and source of earning Which finally help for healthy

growth of family.

2. Training and awareness to the self-help groups for income generation.

E. Other Social Welfare Activities

1. Financial & infrastructure assistance during disaster & other crisis incidents

2. Sustainable livelihood and Farming Systems by providing awareness on various

agricultural practices for better yield, pesticide and fertilizer management, etc.

3. Other social activities depending upon timely requirements & circumstances

4. Promoting sports and cultural activity.

Note: This CSR plan shall include systematic funding provisions for 5 years.


(In Rs Thousand)

Sr. no. Area of Work 2016 to 2017

2017 to 2018

2018 to 2019

2019 to 2020

2020 to 2021

1. Promoting Education 28

28

28

28

28

2. Promoting Health care 25 25 25 25 25

3. Sanitation 20 20 20 20 20

4. Water 22 22 22 22 22

5. Women Development activities 35 35 35 35 35

6. Other Social Welfare Activities 30 30 30 30 30

Total 1.60 1.60 1.60 1.60 1.60

Reply regarding violation of water Act under 1974.

Annexure- X

HENI CHEMICAL INDUSTRIES SITE. : PLOT NO.1901/1901A,Phansa Char Rasta,GIDC,Sarigram, (Gujarat), 396 155, INDIA.

REG OFF : VIKRAM, 26 DREAMLAND, SHASTRI NAGAR, MUMBAI 400 082, INDIA TEL: 0091 22 2583 6009, 2582 3357 FAX: 0091 22 2582 0719

24/09/2015 GPCB ID: 41800 To: The Environmental Engineer Gujarat Pollution Control Board Parayvaran Bhavan, Sector 10 A Gandhinagar – 382 101 Sub: Declaration against revocation application submitted by us on 22/08/2015. Ref: Boards Letter No: GPCB/CCA/SRG-96/ID-41800/324128 & GPCB/CCA/SRG-96/ID-41800/324610 dated 20/08/2015. Respected Shri Y.A.Tai, In continuation to our application and as per our meeting & discussion with your good self today at GPCB, Gandhinagar office we humbly submit further clarifications and decelerations on the said matter.

1. As per instructions we have had our water and electricity connection disconnected. The photocopies of the confirmation letter from GIDC and GEB are attached herewith.

2. The declaration given by us in 2013 was a misunderstanding from our side. We intended to explain that we will carry out only distillation crude ethyl oleate and not carry out the synthetic production of crude ethyl oleate. But due to our misunderstanding/mistake we put crude ethyl oleate distillation in our declaration. Since then we were granted the NOC. And after grant of the NOC we built the facility only to carry out the distillation of crude ethyl oleate. We regret that we did not bring this mistake to the notice of the pollution control board.

3. Following is the process description explaining that the present activity is only distillation and not any synthetic production:

Step 1: We carry out the reaction step which involves use of vegetable oils in our sister concern in Mumbai. This concern has its own EC from Maharashtra Pollution Control Board. The latest consent reference is 1.0/BO/AS(T)/TN-5780-15/R/GEN-07271 dated 01/07/2015. The output of the this step is an intermediate product which we call as crude ethyl oleate. This intermediate product does not fall in hazardous waste category as it is an intermediate product. Step 2 (Carried out at Sarigram): Crude ethyl oleate is separated into two grades in a ration of approximately 80 % and 20 %. This is done in the installed distillation facility at Sarigram plant. Both the grades are sold as ethyl oleate finished product to different customers. There is no residue or hadarzous waste from this distillation.

We hope that the above clarifications/compliances are in line with your requirements and request you to revoke the above said directions at your earliest. We will not carry out the above mentioned distillation activity till board clarifies the matter. We will be more than willing to provide any further information and clarification required. We remain at your disposal.

Yours sincerely, Kapil Girotra Director

Vegetable Oil

Step 1 Step 2: Carried out at Sarigram Intermediate

Product Ethyl Oleate (Grade 2)

Ethyl Oleate (Grade 1)

Corrspondence Address: Plot A-161, Wagle Industrial Estate, Road No 27, Thane: 400604, India. E-MAIL : [email protected] * www.henichem.net

mailto:[email protected]

http://www.henichem.net/

Legal Undertaking for ToR compliance

Annexure- XI

A. Layout Plan

B. Legal Documents (Lease Agreement/ Plot Transfer letter / (Name Change Letter) -Ackw.)

C. CETP Membership

D. TSDF Membership letter

Annexure- XII

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Art ic le 3O(a) Lease - ( lmmovable Property) - Fenl

PLOT NO.190 i l 190 i A ADIv IEAGRING 6587 SQM G I D C

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Lease Agreemen' *r.MfThis Le&se Agrc'ement made at Thane this llh&nqry ' 2012

,N .(ffir.*. rn"**'& Associates(orfu$r/fi;n#i,o o'*,.-*1 'fi,' Rcprescnted bY

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Parmership Firm

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Mls N is i ra H. Thakrar

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Occupation - Industr ial ist

\\rhcreas the properry bcaring plot No

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REAS on accounr of non-using said pior, and the lessor has ftor srn occupyins rhesaid premises.

AND WIEREAS the lessc'e appoached rhe lessor and requesrcd ttte formcr to lease out the sridprcnrises unto to lessee for the purpcee of the nunufacturing buik of finc chinr{cab.

ANrD \!l IEREAS thc lessor has agrced to consider rhe rcquesr made out to him b1' ti..! icssf . lr 4 r!

AND \{IEREAS the panies herero have worked oui the remrs and condiriotts of theiand also dccifu to rcducc thc same inro writiu.

Now rrIIS DEED \\TTNESS, a'd it is h*cby agrecd by ard b+r*.een the panies as follo*s

That the lcssor dobs hcreby lcase out rhe prctrriscs bcaring plor No. ig0llrg0lASarigam CIDC, Utrbargaon Talulca, Valsad Disricr.

That rhc lcsscc shall pav unto the lessor b1,*ay of rcnt fu.i01 pcr monrh an,j sui,h llan'ouut shalt bc payab',c by thc l*'see unro rhc lcssot c'cq, n,oruh i' advance by rl,etc'th day'of such month and also pay seturil Dcposit rls.ri0o0 ar,d securiry dcp+,iru ili rcrurn ro rlic lxsee eftcr tlrc comphxi,rn of rhc lcase pcdod .

Thar in addirion to and ovcr and'above rhc s-aid amoilnr thc hsscr: shall also pay.c\Eivnronth an alllourlt torvards the r,l.atr and elcciricity, ch,argcs.

Thar thc .lesscc

shall ha'c a right Io use and cn;oy rhc sakl gxcmises for chc-rnice,l

J*rposc ans he shall nol allon'any olhcr person to say with him exccpt his guess orroccasions.

That tlrc icssec shall takc all pcssibr,c catc of the p.rc*riscs atd rurniiurc frtii*ss a*rrfi:lurcs provided for rhe seid pr-".tnises.

That thc dots ltctcby *grcc a''d utdcnakc !o vecate tbe soid ptrnriscs a*d hartd ovcrrvncatc and pc:aceful possession thercof unto thc le;sor. lidrc tssor r*.erc !o requir.cdthe satrrc and in that evctrL tlrc ltssor shall give at least orrc n.onrh's inrirnatiol inrlriring rr thc la^sst'c.

Thai ii ltrscc *.anrs k) vacqle tlrr said ptcmises, hc sfall bc ar lib,erg,, to do evsrr+ithoirt gi'ing an1'such nolicc, but thc lcssce shall hand ol.cr racant po.sscssionIl:r'ic".f urii,> ilrt hssct onh'.

{-'-'s;t'c has io takc thc nL\cssr$}' pcrmissian ftonr s*ir-. gorr. Dcp. And r:.niral govt. i\I)cpt. i>u Lis o*n hcft,rc cofitrrtelt{firen! of ihc prod*rct:rrir,.

Thc Lcsscc can bc aliowr:d 1o take ternr loan e1c. From financiai instirurions Bnd tiresaurc p*rrii:;cs can bc hypothccatrd to b,anks a*d lrnancial insrituticx as sriuriry.That thc lcxsr'c conrpan;' mre any permissbn ftom any,(io'ernmcnr auduriry,b1, itso\!'r1 rick and thc hssor rx'ill nor responsibtc for that.

llat all rhc c..:pcnsts oi trr*p dury anJ reci;ri?iifii ciar{es ar-,,, ,c b brnc }1, 1}1alrs:;et i:,11',

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har1di1g or.cr rh,c possessiol of thc sakl ptcmises unto thc bssees and the hssecs shail

be liable to vacatc the said premises and hafi over peaceful and vacant posscssk'n

thercof utrto the lesso,t immediatcly oo the e*piry of the ieasc'

That the iessor shall refund unro the lessees the amount of the security depoe it of Rs'

250O0 ar thc handling ovct thc poesessiol ofthc ptemiscs and said arnolrnt shall ntx

carr)'any* intcrcst.

Thtt if the lcssscs or thcir offrcms \frtrc to cause any danrages ot lcas to the gtmisr:s

or dre said propsrr''. The lessor shall bc entirlc to deduct from rtrc said anrount of dte

sccutity'dcpcsit of Rs.25000 such anpunt of damagc ot loes' \ \ iI,Yt. c-^ \-'-'

Tqx ih,,-r-r be Pcr,d b3 Lass.r{ Y\X.' '

THE SCHEDUI-E OF THE PROPERTY ABOVE REFERRED TO :

Ail thar piecr and parccl bcaring plot No. lg0li l90tA Sarigam, GIDC. Umt'argaor'

Taluka & Dis6ict Valsad admcasuring 6587 Sq.,\{ctcr or rhcir atnuts and bcundcd b1'"ls

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On or toruards thc Nonh ----

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L\i \YITNESSES \\'IIEREOF thc panir:s

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Presented of the office of the Sub-Registrar of

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12 to '13 cn Date 0110212012

1' ' l ' r-t ? lr-olrrrYl , t / s Hen i Chemica l lndus t r ies th rough par tner

N isha Hemendra Thakrar

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S R O . U M B E R G A O N

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UMG244 4

2012

Rece ip t No : - 2012235000362

Received Fees as ' fo l lowingRegistrat ion

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February -2012

P G JADAVSub Registrar

S R.O - UMBERGAON

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l i t i ) e . i t : Request fo r Change o f name f rom M/s . Hen i Chemica l Indus t r ies to M/s . Hen i Drugs Pv t . L td .

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'Hen i Drug Pv t . L td . " & the copy o f the sarne is enc losed as Annexure - I I .

Wr . ' , ; r t : r ' r c lacJeo n the manufac tur lnq o f " Inorgan ic Meta l Sa l ts o f copper , Coba l t , N icke l , B ismuth . MercLr ry &

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upto 10 .06 .2019. t he cop; r o f the sa id consent i s enc losed herewi th as Annexure I I I fo r you f k ind re fe rence

( i ra l t ! , 4ore tha i thc re i s chanqe in the managemeni & the new J is t o f L r i rec to rs i s enc losed herewi th as Annexure IV

i r ) f yor . r r r ( i r - rd re fe r r :nce . K ind ly no te tha t there is no change in Produc t o r Produc t ion capac i ty , Indus t r ia oT ! race

e l l iuen t & No. o f Employees due to chanqe in name & cons t l tu t ion . As a par t o f our assurance to the boarc : ? t . :

h . r ro \ ' v i th subrn i t t ing the no ta ! ' i zed under tak ing on Rs. 100/ - s tamp paper ln ihe name o t bo th un i ts (o ld un i t : M/s .

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