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Slide 1
Annette Thomas, RN, MS, PhD student Nancy Fugate Woods, PhD,
RN, FAAN Ellen Sullivan Mitchell, PhD Janet Schnall MS, AHIIP Soy,
Isoflavones, and Amino Acids for Symptom Clusters During the
Menopausal Transition and Early Postmenopause: A Systematic
Review
Slide 2
Background Women have been reluctant to use HT since the
publication of the WHI results and increasingly have become
interested in CAM therapies Soy & Isoflavones may be a good
alternative for women who experience Hot Flashes as well as other
associated symptoms such as problems with cognition, sleep, mood,
or pain.
Slide 3
Background SoyIsoflavones Transformed by intestinal flora
during digestion Phytoestrogen Regulates the estrogen levels in the
body 30% of population can convert Diadzein into EQUOL Diadzein
Genistein Glyceiti n
Slide 4
Aim To review controlled clinical trials of Soy, Isoflavones,
and Amino Acids on hot flashes and at least one other symptom that
women experience during the menopausal transition (MT) and post
menopause (PM) such as problems with sleep, cognitive function,
mood, and pain
Slide 5
Methods Of the 59 unique trials identified of nonpharmacologic
therapies, 17 Soy, Isoflavone, & Amino Acid RCTs were
systematically reviewed: 5 Soy protein 7 Isoflavone 2 Amino Acid 3
Mixtures
Slide 6
Results Soy Protein StudyIntervention/ComparisonHot Flash
SleepCog - fxn MoodPain Basaria 2009 20g soy protein vs. 20g whole
milk protein NSNMNS+NM Hanachi 2008 12.5g soy protein in soymilk
vs. soymilk + walking 1 hour ?NS Jou 2008 6g soy germ extract vs.
roasted wheat +NSNMNS Welty 2007 25g soy protein (soy nuts) vs. TLC
diet (low cholesterol) +NM + Lewis 2006 25g soy in soy flour
muffins vs. ground flaxseed muffings vs. wheat flour muffins
NSNM
Slide 7
Results Isoflavones StudyIntervention/ComparisonHot Flashes
Slee p Cog- fxn MoodPain Evans 2011 Synthetic Genistein (30mg) vs.
Placebo +NM NSNM Carmignani 2010 Isoflavone powder (90mg) vs. HT
vs. placebo +NM ++ Lee 2010 Rexflavone (135mg) vs. placebo ++NMNS+
Albertazzi 2005 Genistein (90mg) vs. placebo+ (HF>9)
NSNMNSNM
Slide 8
Results Isoflavones (contd) StudyIntervention/ComparisonHot
Flashes SleepCog- fxn MoodPain Hildago 2005 Red Clover Isoflavone
(80mg) vs. placebo +++++ Jou 2005 70mg isoflavone vs. 35mg
isoflavone vs. placebo NS+NM+ Uesugi 2004 40mg isoflavone vs.
placeboNS NMNS Key: + is significant for P