Ann E. Rougvie Nature Reviews Genetics 2, 690-701 (September 2001)

Ann E. RougvieNature Reviews Genetics 2, 690-701 (September 2001)

Table 1The role of microRNAs in cancersmicroRNAs TumorigenesismiR-9 NeuroblastomamiR-10b Breast cancermiR-15, miR-15a Leukemia, pituitary adenomamiR-16, miR-16-1 Leukemia, pituitary adenomamiR-17-5p, miR-17-92 Lung cancer, lymphomamiR-20a Lymphoma, lung cancermiR-21 Breast cancer, cholangiocarcinoma, head & neck cancer, leukemia, cervical cancer,

Pancreatic cancermiR-29, miR-29b Leukemia, cholangiocarcinomamiR-31 Colorectal cancermiR-34a Pancreatic cancer, NeuroblastomamiR-96 Colorectal cancermiR-98 Head & neck cancermiR-103 Pancreatic cancermiR-107 Leukemia, pancreatic cancermiR-125a, miR-125b Neuroblastoma, breast cancermiR-128 GlioblastomamiR-133b Colorectal cancermiR-135b Colorectal cancermiR-143 Colon cancer, cervical cancermiR-145 Breast cancer, colorectal cancermiR-146 Thyroid carcinomamiR-155 Breast cancer, leukemia, pancreatic cancermiR-181, miR-181a, miR-181c Leukemia, glioblastoma, thyroid carcinomamiR-183 Colorectal cancermiR-184 NeuroblastomamiR-196a-2 Pancreatic cancermiR-221 Glioblastoma, thyroid carcinoma, Pancreatic cancermiR-222 Thyroid carcinomamiR-223 LeukemiamiR-301 Pancreatic cancermiR-376 Pancreatic cancerlet-7, let-7a, let-7a-1, let-7a-3 Lung cancer, colon cancer

Mol Cancer. 2007; 6: 60.Published online 2007 September 25. doi: 10.1186/1476-4598-6-60.Copyright © 2007 Cho; licensee BioMed Central Ltd.

Cell 2013 154, 311-324DOI: (10.1016/j.cell.2013.06.026)

Ann E. RougvieNature Reviews Genetics 2, 690-701 (September 2001)

Steven M. Johnson , Helge Grosshans , Jaclyn Shingara , Mike Byrom , Rich Jarvis , Angie Cheng , Emmanuel Labouri...

RAS Is Regulated by the let-7 MicroRNA Family

Cell, Volume 120, Issue 5, 2005, 635 - 647

http://dx.doi.org/10.1016/j.cell.2005.01.014

Steven M. Johnson , Helge Grosshans , Jaclyn Shingara , Mike Byrom , Rich Jarvis , Angie Cheng , Emmanuel Labouri... RAS Is Regulated by the let-7 MicroRNA Family

Cell, Volume 120, Issue 5, 2005, 635 - 647http://dx.doi.org/10.1016/j.cell.2005.01.014

Let-7g impairs proliferation and enhances cell death.

Kumar M S et al. PNAS 2008;105:3903-3908

©2008 by National Academy of Sciences

Let-7g-induced tumors maintain overexpression and target suppression.

Kumar M S et al. PNAS 2008;105:3903-3908

©2008 by National Academy of Sciences

K-RasG12D substantially rescues let-7g-mediated tumor suppression.

Kumar M S et al. PNAS 2008;105:3903-3908

©2008 by National Academy of Sciences

miR-26a facilitates gliomagenesis in vivo.

Huse J T et al. Genes Dev. 2009;23:1327-1337

©2009 by Cold Spring Harbor Laboratory Press

miR-26a represses PTEN expression in murine gliomas.

Huse J T et al. Genes Dev. 2009;23:1327-1337

©2009 by Cold Spring Harbor Laboratory Press