Anatomic Pathology Histology Services - Covance · 2017-09-16 · Customized Solutions–for Greater Flexibility. Our team of experts is dedicated to providing exceptional services

Anatomic Pathology Histology Services

Central Laboratory Services

Oncology and Beyond...

Thereisnoquestionthatinnovationsintechnologyhavethepotentialtosignificantlyimpactanumberofclinicalapplications.Buttechnologyalonecan never fully actualize its potential.

Itisnotuntiladvancedtechnologiesareplacedintheskillfulhandsofanexperienced team of experts–experts in science, in process, in medicine, and logistics–that we will fully realize the value of these advances.

Inresponsetotheevolvingneedsoftheindustry–consistency,specimenintegrity,andefficiency–wechallengedourselvestolook beyond and deliver.

That is, until you look beyond.

Tissue Processing ServicesQUALITY AND CONSISTENCY BEGINS . . . AT THE

BEGINNING!

Our dedication to consistency is evident from the very beginning. Combining extensive automation with manual customization capabilities, our automated kit production facility delivers globally uniform specimen collection kits to assure consistent collection across all sites.

Consistency – Assuring quality trial data

• Standardizedbiopsycollectionkitsforconsistent site-to-site specimen collection

• Strictadherencebyexperiencedin-househistotechnologiststoSOPsforgrossdescription

• Specialhandlingforspecimensthatwillundergoimmunohistochemistry(IHC),fluorescentin situ hybridization (FISH),ornucleicacidpreparation

Specimen Integrity – Protecting your valuable assets• Datarecordsfolloweachspecimenforameticulousaudittrail• Reducedexposuretoexcessfixatives

Uniform sample collection kits • To reduce errors and

increase global consistencySuperior logistics solutions • To mitigate risk of lost or

damaged samplesIn-house tissue processing • For sample integrity

Collection & Processing

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[ ]Histochemical Staining ServicesCONSISTENCY DOWN TO A SCIENCE–LITERALLY.

Our in-house automated stainers are capable of performing a wide rangeofstains,includingroutineH&Estainingalongwithavarietyofspecialstains.Automationoffrequentlyperformedstainingdeliverstheutmostefficiencyandconsistency.Forlowervolumestainingtasks,ourhighlytrainedhistotechnologistsfollowstrictmanualstainingSOPstodeliverconsistentresultswhilemaintainingefficiencyforyourstudies.

Genomics & Biomarker AssaysTHE FINE ART OF TISSUE SCIENCE.

Theanswersareinthedetail.Andourattentiontodetailisexacting!Frompreciseinterpretationtoon-timedeliverytoreal-timeflexibility,we offer solutions to meet the precise standards of your trial.Tissue biomarker assaysExtensive options for customized solutions: We utilize a global network ofreferralandin-houselaboratoriestoprovidethemostefficientsolutionforyourIHCorFISHassays.Forrapidturn-aroundtimes,weworkwithseverallaboratoriesintheUSthatprovideaccesstoacomprehensive menu of biomarkers. Diverse pharmacogenomics capabilitiesGenomics solutions you can depend on: We combine the capabilities ofourin-houselaboratoriesatCovanceCLSsitesandourSeattle-basedCovanceGenomicsLaboratory,aswellasspecializedreferrallaboratories to deliver a complete genomics solution.Global pathologist expertiseSpecialists you can trust: Tissue biomarker specialist interpretations are provided via our network of referral lab pathologists to provide the right specialist for your study, or we can utilize a pathologist of yourchoosing.Eitherway,youwillgettherightexperttoprovideaccuracy and consistency.

Automated staining • For superior consistencyTissue biomarker expertiseNetwork of referral labs • Complete global solutions

Staining & Assays

Human breast tissue immunohistochemically stained to demonstrate estrogen receptor production.

Digital Pathology Services• Digitalslidescanningforarchivalimagestorage• Copies of images available on media• In-housetargetlesiontissueidentificationby

CovanceCLSpathologists• Target lesion percent and area determination• Remoteaccesstospecimenimages• Target lesion macrodissection for enrichment

Digital Pathology Services TAKING TECHNOLOGY AND MAKING IT BETTER.

Often, the most powerful innovation is the process that supports the technology. Covance looked beyond to imagine how to deploy the power of digital pathology to better meet the needs of your uniquetrials.

Specimen Security and Integrity. YourCovanceDigitalPathologyServicesteamcandeliverthesamehigh-qualityresultsfrompatientsnextdoororaroundtheglobe.Scienceandoperationsworktogethertoanticipateandrespond to the rigors of managing your delicate pathology samples.

Specimen handling in a single location, including tissue processing, staining, target feature identification, and even storage, reduces the risk of loss or damage and protects your valuable assets.

Exceptional Data Consistency. Allspecimensarereviewedbyaconsistentteamofpathologistsworkingtogetherunderthesameexactingstandards.Additionally,remote access to slide images can be available for secure and efficientreviewbyyourpathologists.

Greater Accuracy. The deployment of advanced technologies delivers greater consistencyandresultsinfastertrialenrollmentdecisions.Reducedshipment of slides helps to mitigate risk of loss or damage and eliminates costly handling steps and long turn around times.

Customized Solutions–for Greater Flexibility. Our team of experts is dedicated to providing exceptional services from the simplest to the most complex laboratory services. We create customized solutions for every trial, based on tissue andtumortype,stainingrequirements,andtheneedfor customized assays.

Aperio’s ScanScope® system consistently delivers digital slides with superior image quality.

Digital image of a human tissue marked to guide macrodissection

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In-house target identification • Rapid decisionsSpecialist interpretation via referral laboratory network • Options for sponsor-

chosen pathologists

Analysis

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Embedding and Sectioning ServicesSAME ADVANCED EQUIPMENT. SAME EXACTING

STANDARDS.

We can’t overemphasize the need for consistency. That’s why we deploy the same advanced technologies according to the same exacting procedures regardless of where your specimens are processed, producing highly combinable results.

Within this framework of consistency, we are also able to offer a host of options:Routine and nuclease-free services• Specialhandlingofsamplesforgenomicstestingtoeliminate

contamination or degradation• Varietyofnucleicacidpurificationservices,including

formalin-fixed,paraffin-embedded(FFPE)DNA/RNAextraction

Sectioning of paraffin-embedded tissues or cell blocks using microtomes• Standardorcustomizedthickness,dependingonyourprotocolSections mounted on slides or captured in microcentrifuge tubes for downstream processing• Standardorpositivelychargedglassslidesandpolyethylene

naphthalate(PEN)slidesforlasercapturemicrodissection• Standardandnuclease-freemicrocentrifugetubes

Stringent SOPs • For consistent resultsNuclease-free services available • To guard against cross-

contaminationFFPE DNA/RNA isolation • To meet specific study

requirements

Specimen Allocation

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Automated kit production facility assures consistent tissue collection for quality trial data.

Tissue sectioned on a microtome–standardized processes assure consistent quality.

Specimen ManagementYOUR SPECIMENS ARE AMONG YOUR MOST VALUED

ASSETS. Covance looks beyond the slide and understands it represents much more–a clinical trial that could deliver life-saving therapies to the patients represented by that single slide. We are committed to guarding these precious assets at every stage.

Processing – To meet your specific study requirementsTo manage embedded tissue blocks and slides, Covance offers:• Pathologyreportimaging• BlockIDconfirmation• Anatomicsiteandsampleintegrityverification

Storage – Ensuring sample integrity whenever your specimens are neededAnequallyimportantstepintheprocessisthestorageofyourirreplaceable specimens for continued sample integrity. With over 20 years of experience, we utilize sophisticated biorepository systems to store your samples under extreme conditions, ranging from ambient temperature to -150º C. Logistics – Mitigating the risk of loss or damage• Slidesandtissue/cellblocksbar-codedforreliableidentification

and tracking• Logisticsmanagementofshipmentsbetweenstoragefacilities,

investigator sites, and referral laboratories • Specimensandresultstrackedandmanagedusing

ourLabLink+application

THE AMERICAS +1.888.COVANCE (+1.888.268.2623) +1.609.419.2240

EUROPE/AFRICA +800.2682.2682 +44.1423.500888

ASIA PACIFIC +800.6568.3000 +65.6.5677333

www.covance.com

Covance is an independent, publicly held company with headquarters in Princeton, New Jersey, USA.

Covance is the marketing name for Covance Inc. and its subsidiaries around the world.

©Copyright 2012, Covance Inc. BROCLSO21-1012

Now it’s your turn to look beyond.

Look beyond and imagine other services you might need– whether that is unstained slides or customized services provided either in-house or through our network of specialty laboratories. Our goal is to work as partners for the advancement of critically needed pharmaceutical and biotechnical therapies for patients around the globe.

Central Laboratory Services

Specimen tracking via LabLink+ • To protect specimensAdvanced biorepository • For specimen integrity

over time

Storage