Analyzing the Increased and Decreased Expression of Microarray Data for Vibrio cholerae Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB, Calderwood SB, Schoolnik GK, and Camilli A. Host-induced epidemic spread of the cholera bacterium. Nature 2002 Jun 6; 417(6889) 642-5. J’aime Moehlman Amanda Wavrin April 27 th , 2010 BIOL 398/S10: Bioinformatics Lab
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Analyzing the Increased and Decreased Expression of Microarray Data for Vibrio cholerae Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB,
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Analyzing the Increased and Decreased Expression of Microarray Data for Vibrio
cholerae
Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB, Calderwood SB, Schoolnik GK, and Camilli A. Host-induced epidemic spread of the cholera bacterium.
Nature 2002 Jun 6; 417(6889) 642-5.
J’aime MoehlmanAmanda WavrinApril 27th, 2010
BIOL 398/S10: Bioinformatics Lab
Outline• Vibrio cholerae is a waterborne disease that is infectious
to humans• Microarray data is used to measure gene expression• Microarray data from the Merrell et al. (2002) study• Increased processes and organization result in a more virulent strain• Decreased overall organization results in increased pathogenicity• Significantly changed genes in comparison to Merrell
• Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB, Calderwood SB, Schoolnik GK, and Camilli A. Host-induced epidemic spread of the cholera bacterium. Nature 2002 Jun 6; 417(6889) 642-5.
• Todar, Kenneth. Online Textbook of Bacteriology “Vibrio cholerae” http://www.textbookof bacteriology.net/cholera.html. 25 April 2010.