Analytical Solution for Management of Biotech & Pharma Innovation Data collection, data warehousing, analytical design, data analysis and communication.

Analytical Solution for Management of Biotech &

Pharma InnovationData collection, data warehousing, analytical design, data analysis and communication of results

Joint Research Project

Dr Daniel Pardo CNRS.France

Dr Eric Jolivet University Toulouse 1.France

Dr Andrei Mogoutov AGUIDEL.

Objectives

Development of a complete directory of Biotech Companies and Labs in France, data collection & update tools, communication services and analytical & reporting tools

Related Products & Services Data collection and management of online directory « Biotech » actors in France

using online questionnaire, existing databases, institutional contacts, company websites and press releases

Consulting services Positioning of companies, projects, products, patents, publications, research fields Startup support Early warning Partnership network building Advice on local promotion Advice on foundation and management of « clusters » Evaluation of projects Market and technological studies Benchmarking, competitiveness Consultancy for valorization actors Communication strategy development Academic research

Software solutions: On-line applications, off-line applications, customized solutions, integration of customers data, analytical tools

Data analysis: Custom methods for the analysis of complex & heterogeneous datasets, text and data mining, relational analysis, GIS, scientometrics

Data Base of Biotech Actors in France ACTORS: Detailed information for public and private

institutions name typology location contacts HR main financial figures technologies products application areas clinical trials customers partners and collaborations company structure and history

LITERATURE: Publications in biomedical journals PATENTS: biotech patents filed in patent offices

Design of Analytical Solution (on/offline)

Back Office-data tables- textual analysis- tools for data update and control

Front Office

Middle Office- a layer of analytical queries - pre-defined queries for multilevel - aggregation, synthesis, indicators

- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts)- statistical tables, indicators and textual synthesis- integrated querying tools

DATA UPDATE FEED-BACK

Back Office

Patents

Actors

Literature

Links

ProductsProjects

J ohnson & J ohnson

Glaxo SmithKline plc

Aventis

Wyeth

Merck & Co. Inc.

Roche

Bristol-Myers Squibb Co.

Schering-Plough Corp.

Pfizer

Novartis

Pharmacia

Eli Lilly and Co.

Bayer AG

AstraZeneca

Abbott

NETWORK ORIENTED DATABASE

TechnologiesClusters

A case study:

INSERM . FRANCE

Industrial Partnership Analysis

Valorization & Technology Transfer Department(1980-2003)

Partnership of INSERM Valorization & Technology Transfer Department (1980-2003)

0

20

40

60

80

100

120

140

1980 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003

Nb Of Partners

Nb Of New Partners

Nb Of Contacts

Number of Contracts, Partners and New Partners per year

Main Partners of INSERM Valorization & Technology Transfer Department (1980-2003)

0 20 40 60 80 100 120

BIODE RMA

T ROP HOS

AGUE T T ANT

BIOMAT LANT E

CAP T E LS

E XONHIT

INNOT HE RA

Labor atoi r es GE NE VRIE R

LABORAT OIRE S LE O

Mi l leGen

Monoclonal Antibodies T her apeutics (MAT )

NUCLE IS

ORP HACHE M

VIVALIS

AP CE LLS SA

BIOCOM

LABORAT OIRE L. LAFON

LAE NNE C T E K

P RE IN AND P ART NE RS [LASE RSONICS]

T CLAND

T RANSP HY T O

BIOVE CT OR T HE RAP E UT ICS

DIACLONE

IP SOGE N SAS

LABORAT OIRE S GOE MAR

CORAM

ME T ROVISION

SOLY ME S

SY NT E M

CE RE P

RACIA-ALVAR

ST ALLE RGE NE S

BE SINS INT E RNAT IONAL

GE NSE T S.A.

Labor atoi r e P asteur - CE RBA S.E .L.A.F.A.

LAP HAL

SAT E LE C

INNAT E P HARMA

OVI

BIOCY T E X

LABORAT OIRE S LACT E OL

LABORAT OIRE FRANCAIS DU FRACT IONNE ME NT E T DE S BIOT E CHNOLOGIE S-LFB

IMMUNO-DE SIGNE D MOLE CULE S

T E CHNOME D

T RANSGE NE

BIOP RE DIC Inter national

HY BRIGE NICS S.A

BIOP ROJ E T

IMMUNOT E CH/ BE CKMAN-COULT E R

Areas of Partnership of INSERM Valorization & Technology Transfer Department (1980-2003)

0

50

100

150

200

250

1980-85 1986-90 1991-95 1996-00 2001-03

Biotechnologie/Médicament

Technologie biomédicale

Médicament/Vaccins

Bioréactif/Recherch/Diagnostic

Santé publique

Recherche clinique

Agroalimentaire

INSERM Technology Transfer Contracts

Firms StartUps ME Other/ Research Institutes

1980-2000 22 26 201 38

2001-2003 18 66 73 52

Relational Mapping Of Data Base Heterogeneous network analysis with

Réseau-Lu © (www.aguidel.com) ReseauLu Project:

Data Mining & Text Mining for social sciences ReseauLu software finds patterns and relationships in

data by using statistical and network analysis techniques.

In addition to algorithms, the software has features to simplify the graphical representation of the data structures.

The software simplifies the integration of analytical algorithms and visualization tools with database technology.

Main Areas of Partnership of INSERM Valorization & Technology Transfer Department (1980-2003) Per Period

Biotechnologie/Médicament

2001-03

1996-00

Technologie biomédicale

1991-95

Médicament/Vaccins

Bioréactif/Recherch/Diagnostic

1986-90

1980-85

Santé publique

Recherche clinique

Agroalimentaire

INSERM Bio-technological Network: Areas of Partnership of INSERM vs. Companies

IMMUNOTECH/BECKMAN-COULTER

Immunologie

Neurologie/NeurobiologieBIOPROJ ET

Cancérologie

HYBRIGENICS S.A

Biologie cellulaire

BIOPREDIC International

TECHNOMED

TRANSGENE

Chirurgie

IMMUNO-DESIGNED MOLECULES

Nutrition

Endocrinologie/maladies métaboliques

OVI

Virologie/SIDA/MST

BESINS INTERNATIONAL

Néphrologie - Urologie

LAPHAL

SATELEC

INNATE PHARMA

Biologie moléculaire

Hématologie

BIOCYTEX

Cardiologie

GENSET S.A.

LABORATOIRES LACTEOL

Transplantation (greffe)

Toxicologie

Gastro-entérologie

Hépatologie

Génétique médicale/Maladies génétiques et congén.

Epidémiologie

Dermatologie

Pathologie vasculaire

Orthopédie

Ostéoporose

Autres maladies infectieuses et/ou transmissibles

Biomathématiques et biostatistiques

Reproduction, fertilité

Laboratoire Pasteur - CERBA S.E.L.A.F.A.

Physiologie/Physiopathologie

Biochimie

Inflammation

Microbiologie

INSERM labs vs. Companies

IMMUNOTECH/BECKMAN-COULTERHU U 573

BIOPROJ ET

BIOPREDIC International

INSERM U 556TECHNOMEDLABORATOIRES LACTEOL

TRANSGENE

BIOCYTEX

INSERM IFR 75

INSERM U 258

IMMUNO-DESIGNED MOLECULES

INSERM U 448

INSERM U 510

CF U 277

HYBRIGENICS S.A

HU U 454

INSERM U 119

INSERM U 280

INSERM U 522

INSERM U 255

CNRS U 136

HU U 596

INNATE PHARMA

ORPHACHEM

Laboratoire Pasteur - CERBA S.E.L.A.F.A.

BESINS INTERNATIONAL

SYNTEM

RACIA-ALVAR

HU U 437

STALLERGENES

INSERM IFR 57

INSERM U 268

SOLYMES

CNRS U 463

INSERM U 519

INSERM U 370

TCLAND

PR U 136

INSERM ERM 322

SATELEC

INSERM U 476 U U 455

AP U 457

U U 461

CNRS U 528

INSERM U 590

U ERM 203

BIOCOM

BIOMATLANTE

U U 463

INSERM E 9903

U U 136

INSERM E 3

GENSET S.A.

HU U 399

HU U 428

HU U 430 INSERM E 350

Monoclonal Antibodies Therapeutics (MAT)

LAPHALAGUETTANT

INSERM U 412

LABORATOIRES GOEMAR

INSERM U 484

INSERM U 564

LABORATOIRE L. LAFON

INSERM U 571

HU E 9906

GENOPOIETIC

INSERM E 116

DYNABIO

CNRS U 533

INSERM U 589

CNRS U 400

INSERM U 588

CEREP

Centre International de Toxicologie

NUCLEIS

LABORATOIRES LEO

LAENNEC TEK

MEDecine-BIOlogie-MEDiterranée

MilleGen

CNRS U 520

INSERM U 514

INSERM U 431

INSERM U 450

INSERM U 271

Optis France

INSERM U 488

INSERM U 540

INSERM U 536

HU U 533

INSERM U 478

HU U 541

IPSOGEN SAS

AP CELLS SA

PR U 393

Bioalliance Pharma

HU U 503

BIODERMA

INSERM U 460

CNRS U 582

DIACLONE

INSERM U 525

ARKOPHARMA

VIVALIS

ZZ U 258

INSERM IFR 116

HU CIC 6

INNOTHERA

INSERM U 463

PROSKELIABIOVECTOR THERAPEUTICS

EXONHIT

INSERM U 136

CliniGenetics

“French BioIndustry” – Data Base First data set - 450 companies Preliminary data Exploratory analysis First Draft

Working “Paper” – 15/06/04

French biotech collaboration network

INSERM

CNRS

Aventis

PROTEUS S.A.

IDM SA

IMSTAR

GENOWAY

GENFIT

INRASanofi-Synthélabo

IPSOGEN

NUCLEIS SA

CEA

AVIDIS

Institut Curie

Merck & Co.

Pierre FABRE

Cambridge University

Degussa

Exonhit

FLAMEL TECHNOLOGIES

Curie Institute

THERAPTOSIS

Obetherapy Biotechnology

Servier

RD-BIOTECH

Cellectis

Pasteur Institute

Optis

Oncodesign

Accelrys

Aventis Pasteur

MolecularEnginesLaboratories

Abbott

BioMérieux

IRD

MedarexBIOSTATEM

UCB Pharma

TRANSGENE

DIATOS SA

Cytheris SA

Urogen

BTPharmaHYBRIGENICS S.A

VIVALIS

NICOX

Neovacs SA

Nautilusbiotech

Millegen

MetabolixExplorer

TcLand

It-Omics

Drugabusesciences

PROSKELIA PHARMACEUTICALS

INNOPSYS

Syntem

INTEGRAGEN

GeneOdysse

Eurorad

MatbioPharma

Midi Pyrénées Region: Heterogeneous NetworksCompanies & Technologies of Midi Pyrénées Region “Very preliminary analysis” Source: MidiBiotech survey Next steps:

Systematic collection of exhaustive data Scientific analysis of data

biologie moléculaire

biochimie

Drug delivery

immunologie

pharmacologie toxicologie

bioinformatiqueCAYLA SARL

ENDOCUBE

enzymologie

GTP Technology

INNADEV PHARM

MILLEGEN

SCANELIS

PHYSIOGENEX

ACTIGENICS

nanobiotechnologieKOBO PRODUCT

NANOBIOTIX

AVOGADRO

ARGENE BIOSOFT

ABTECH (Paris)

expérimentation animale

Institut Européen de Biologie Cellulaire I.E.B.L.A.R.A. Laboratoire - Europe Sols

BT Pharma

BIOSENTEC

physiopathologie

biologie cellulaire

ABTECH (Toulouse)

INNOPSYS

génomique

génétique animale

thérapie génique

recherche clinique

fermentation

Additional Analysis: Scientometrix of publications database Case study : Research Community on Mental

Retardation and Genetics Source – PubMed data base

Pimentel MM

Fryns J P

Chelly J

Munnich A

Moraine C

Vekemans M

van Bokhoven HYntema HG

Ropers HH

Cormier-Daire VGosset PPrieur M

Hamel BC

Le Merrer M

Colleaux L

Lyonnet S

Raynaud M

Turleau C

Amiel J

Niikawa N

Matsumoto NOhashi H

Romana S

Frints SG

des Portes V

Fukushima Y

Oudakker AR

Ozilou C

De Blois MC

Rio MRaoul O

Kleefstra T

Kurosawa K

Moizard MP

Faivre L

de Vries BB

Yoshiura KOkamoto NKondoh T

Gomot M

Kalscheuer V

Kalscheuer VM

Gécz J

Harada N

Lacombe D

Marynen PFroyen GPartington M

Turner G

Hamel B

Oostra BA

Kishino T

Borghgraef M

Briault S

Kurotaki N

Neri G

Philip N

Renieri A

Guerrini R

Meloni I

Hagerman RJ

Devriendt K

Schwartz CE

Hagerman PJ

Ogata T

Kerr B

Tassone F

Bienvenu T

Verloes A

Larizza L

Mandel J L

Mégarbané A

Scheffer IE

Strømme P

Gottardi GFinelli P

Bardoni B

David A

Lev D

Gecz J

Willemsen R

Toutain A

Grigsby J

J acquemont SStevenson RE

Goto Y

Brunner HG

Giardino D

Schinzel A

Dobyns WB

Carrozzo R

Shaffer LG

Schenck A

Das S

Zollino M

Lubs HA

Waschek J A

Bongarzone ER

Weiler IJ

Campagnoni AT

Stankiewicz P

Schonmann V

Kooy RF

Romano C

Syrrou M

Sherman SL

Clayton-Smith J

Chiurazzi P

Starke H

Warren ST

Kubota T

Kashork CD

Silengo M

Lelievre V

Bakker CE

Lerman-Sagie TRagusa A

Itoh M

Hu Z

Reyniers E

Greenough WT

Riegel M

Liehr T

Bartsch O

Bocian E

Morava E

Weeber EJ

Flint J

Walsh CA

Sweatt JD

Mazurczak T

Nakao M

Gal A

Komaki H

Biesecker LG

Hennekam RC

Lubec G

Jakobs C

Nelson DL

Schanen C

Rauch A

Kutsche KBassell GJ

Hanauer A

Korenberg JR

Kunze J

Hayek G

Estivill X

Oshimura M

De Vellis J

Graham JM

Andria G

Mental retardation & Genetics co-authorship network 2001-2004

Highly Clustered Network with mediation through individuals

Autism & Genetics semantic network 1964-2003

Syndromic approach

autismgene

syndrome

child

chromosome

patient

family

serotonin

mutation

association

region

analysis

childhood

polymorphism

mental

parent

linkageschizophrenia

receptor

marker

psychiatric

rett

genetics

disequilibrium

phenotype locus

mecp

human

retardation

transporter

deletion

language

susceptibility

behavior

multipleincidence

impairment

relative

duplication

promoter

deficit

spectrum

specific adult

aspect

attention

boy

candidate

diagnosis

hyperactivity

expression

complex

abnormality

history

evaluation

characteristic

transmission

platelet

subunit

psychosis

screening

personality

sclerosis

sibling

onset maletwo

variant

young

translocation

autosomal

relationship

connection

cytogenetic

sex

ratio

strategy

symptom

dup

touretteasperger

treatment

anomaly

angelman

adolescent

beta

phenotypes

medical

minor

investigation

inv

intellectual

monozygotic

neurobiology

novel

hoxa

hla

disability

perspective

psychiatry

fmr

finding

female

population

possible

etiology

epilepsy

probands

problem

mapping

heterogeneity

Alcimed

AVIDIS

GeneIt

Galenix Development

SkinEthic

Bionisis SA

PROTEIN'-EXPERT

Picometrics

BiométhodesSA

Pfizer

BIOSTATEM

Glaxosmithkline

PolymerExpert

Innovaction

Idealp-Pharma

Aventis

Servier

Roche

APTERYXMabGene

Sanofi-Synthelabo

CNRS

BMS

INSERM

Entomed

AureusPharma

BIOPROJ ET

Galderna

Adiatec SA

IPSOGEN

L'Oréal

Eli Lilly

Trophos

Innate Pharma

Sanofi

J &J

UCB

BioMérieux Exelixis

Confidential

Curagen Corporation

Evologic

European Bioinformatics Institute (EBI)E.I. DuPont de Nemours

European Big pharma & biotech companies

Galderma

Ellipse Pharmaceuticals

ETHYPHARM

french and european leaders of food industry

Diatos

BIO-RAD

Amgen

Aptanomics

Astra Zenecca

AVENTIS PASTEURAVENTIS PASTEUR MSD

Aventis PharmaBarr Labs

BASF........

Baxter

Biosite

BESINS INTERNATIONAL

Chelatec

Bionexis

Bioprotein

BIOVAIL

Boehringer Ingelheim

BTPharma

CEA-Life Science Division

CERMER

Charabot

CHAUVIN

Bayer

Sangstat

Hopitaux universitaires de Genève

Neurotech

Novartis

Nycomed Imaging S.A

Ondeo

Ophthalmic distributors

Ophthalmic industries

Organon P&G

Pasteur Institute

phamraceutical groups in France and Europe

MYCOSPHERE S.a.r.l.

RhoBio

Milkhaus

Sorebio (Ares Serono)

Sumitomo

TEVA

Thomson Derwent.

Trèves

Urogene

USA Customers

USDA

VETOQUINOL

VigiCell

Wyeth

RD-BIOTECHIpsen

Genencor International

Genethon

Genoscope

Genzyme

Groupe Fournier

Henkel

3M

IMTSSA

YAMANOUCHI

Infobiogen

Inpharzam

NEUROLAB

Integragen

GEMACBIO (Gemac SA)

IRBM spA-Merck Italy

Isover saint-Gobain

IVAX

Laboratoires Ceraver.

Lancaster/Coty

LVMH

major pharmaceutical and agrochemical companies

Merck

MERCK Generics

MERCK SANTE

MêTiS Biotechnologies

Inserm.Protein'eXpert

French biotech market structure – subset of Network of Clients

Squares – subset of companies, circles – clients