AMPK-α(1,2) AMPK-β(1,2) AMPK-γ(1,2,3) TAK1 Leptin AMP/ATP LKB1 ATM Akt IL-6 Insulin PP2C CaMKK Ca 2+ Adiponectin Lipolysis Fatty Acid Synthesis Cholesterol Synthesis Fatty Acid Oxidation Fatty Acid Uptake HSL HMG-CoA Reductase PEPCK G6Pase AS160 TBC1D1 MEF2A MEF2D Malonyl-CoA SREBP-1C ACC1 ACC2 CPT-1 MCD LPL CD36 Glycogen Synthesis GLUT4 Biogenesis GLUT4 Translocation Glucose Uptake Glycolysis Gluconeogenesis GSK-3 GS PFK2 NO Synthesis Energy Expenditure eNOS NAD + / NADH TSC1/ TSC2 4EBP1 eIF4E SIRT1 Protein Translation Initiation Peptide Elongation Mitochondrial Biogenesis Protein Translation eEF2K eEF2 mTOR RheB p70S6K PGC-1α S6 NRF-1 AICAR Exercise Discover more at abcam.com/AMPKsignaling AMPK Signaling: The Fuel Sensor and Regulator Pathway Produced in collaboration with Ding An, Ph.D., Postdoctoral Fellow and Laurie J Goodyear, Ph.D., Associate Professor of Medicine, Harvard Medical School & Senior Investigator and Head, Section on Metabolism, Joslin Diabetes Center. Legend: Regulation of AMPK Lipid Metabolism Carbohydrate Metabolism Protein Synthesis Others Activation Activation (not fully confirmed) Inhibition
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AMPK-α(1,2)
AMPK-β(1,2) AMPK-γ(1,2,3)
TAK1
Leptin
AMP/ATP LKB1 ATM Akt
IL-6Insulin
PP2CCaMKKCa2+
Adiponectin
Lipolysis
Fatty AcidSynthesis
CholesterolSynthesis
Fatty AcidOxidation
Fatty AcidUptake
HSL
HMG-CoAReductase
PEPCKG6Pase
AS160TBC1D1
MEF2AMEF2D
Malonyl-CoA
SREBP-1C
ACC1
ACC2
CPT-1
MCD
LPLCD36
GlycogenSynthesis
GLUT4Biogenesis
GLUT4Translocation
GlucoseUptakeGlycolysis
Gluconeogenesis
GSK-3
GS
PFK2NO
Synthesis
EnergyExpenditure
eNOS
NAD+/NADH
TSC1/TSC2
4EBP1eIF4E
SIRT1
ProteinTranslationInitiation
PeptideElongation
MitochondrialBiogenesis
ProteinTranslation
eEF2K
eEF2
mTORRheB
p70S6KPGC-1α
S6
NRF-1
AICARExercise
Discover more at abcam.com/AMPKsignaling
AMPK Signaling: The Fuel Sensor and Regulator Pathway
Produced in collaboration with Ding An, Ph.D., Postdoctoral Fellow and Laurie J Goodyear, Ph.D., Associate Professor of Medicine, Harvard Medical School & Senior Investigator and Head, Section on Metabolism, Joslin Diabetes Center.