Amino acid transmitters Glutamate (GLU) –excitation of neurons GABA (Gamma-amino butyric acid) – inhibition of neurons Choices of antiepileptic drugs First line Second line Partial seizure Carbamazepin e Iamotrigine, phenytoin, tiagabine, topiramate, valproate, gabapentin Generalised tonic-clonic Valproate Carbamazepin e Iamotrigine, phenobarbito ne, phenytoin, topiramate Absence (petit mal) seizures Valproate Ethosuximide Clobazam, clonazepam, iamotrigine Status epilepticus IV diazepam/ midozolam/clonazepam
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Amino acid transmittersGlutamate (GLU) –excitation of neurons
GABA (Gamma-amino butyric acid) – inhibition of neurons
Choices of antiepileptic drugs
First line Second line
Partial seizure
Carbamazepine Iamotrigine, phenytoin, tiagabine, topiramate, valproate, gabapentin
Generalised tonic-clonic
ValproateCarbamazepine
Iamotrigine, phenobarbitone, phenytoin, topiramate
Absence (petit mal) seizures
ValproateEthosuximide
Clobazam, clonazepam, iamotrigine
Status epilepticus
IV diazepam/ midozolam/clonazepam
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