Amines April 6, 2005 Compounds By: Names of Team Members Ibuprofen.

Amines

April 6, 2005

Compounds

By: Names of Team Members

Ibuprofen

Goals: Amines

• What amines are.• What things in our life

contain amines.

Amines, what are they?

• Organic molecules that correspond to ammonia, NH3, in which one, two, three, or all three of the hydrogen atoms have been replaced by R groups (chains or rings) of carbon atoms (with their associated hydrogen atoms).

How do we recognize an amine?

• Amine group: is a nitrogen atom with two bonded atoms or groups.

• Ammonia molecule

• The names for many amines end in ine.

• Ex: CH3NH2 is called methylamine.

Physical properties

• High melting points and boiling points compared to similar alkanes.

• High solubility in aqueous solutions.

• Amines have odors that disgust us.

Amines that stink

• The bad smells come from amines that contain two amino nitrogen atoms or diamines.

• Rotting fish produce trimethylamine (CH3)3

• Others things that smell because of amines are: Urine, bad breath, and semen.

Structure of amines

• N atom bonded either to C or H atoms

• Both the C-N and the N-H bonds are polar

• 

Everyday amines

• Antidepressants

• Prozac and Paxil

• These two drugs are mood-altering

• They increase the concentration of serotonin, which is an amine.

Everyday amines

• Nicotine

• Consists of molecules of one pyridine ring and one pyrrolidine ring joined by a single bond.

• It raises heart rate, blood pressure, and adrenaline, which is an amine.

• Nicotine is addictive.

Nicotine

Everyday amines

• Caffeine

• Contain four nitrogen atoms with one six-membered ring and one five-membered ring

• Remains in the bloodstream twice as long as nicotine.

• The lethal does of caffeine is 10 grams or about 100 cups of coffee drank quickly.

Drugs

• Cocaine

• Nitrogen containing compound

• Highly addictive

• Stimulant and a depressant.

Drugs

• Cocaine

• The ionic form of cocaine is snorted by users

• It dissolves in the watery mucus membranes.

• Cocaine hydrochloride is a ionic solid and consequently has a high melting point. (about 200o celcius).

Drugs

• Cocaine

• Cocaine effects the level of the neurotransmitter dopamine.

• Half life: 45 minutes

cocaine

Drugs

• Cocaine• Fun facts• Cocaine also works as a local anesthetic

and was used by dentists in the early 19th century.

• Sigmund Freud advocated using cocaine for depression and used it himself.

• Until 1903 cocaine was used in small concentrations in Coca-Cola

Drugs

• Amphetamines

• An illegal drug.

• In an amphetamine the NH2 group is bonded to a carbon chain that ends with a benzene ring.

• Its structure is similar to adrenaline.

• Amphetamines increases heart rate, energy level, drive, and mood for a short period.

Drugs

• Methamphetamines

• Half life is about 12 hours.

• Has a greater psychological effect than amphetamines.

• Ecstasy is derivative of methamphetamines.

Amines used as drugs

• Painkillers• Most painkillers are nitrogen containing organic

compounds.

• Acetaminophen (a·cet·a·min·o·phen) is known commercially as Tylenol, Panadol, and Datril.

• Combines acidic acid with an amine consisting of a nitrogen group bonded to a benzene ring.

• It is analgesic and an antipyretic meaning it relives pain and fevers.

Drugs

• Painkillers

• Aspirin is an example, it contains a carboxylic acid group and an ester group of acidic acid bonded to a benzene ring.

• Aspirin is an anti-inflammatory.

Aspirin

Drugs

• Painkillers

• Other examples are Ibuprofen also known as Advil, Motrin, Midol, and Nuprin.

• Is an anti-inflammatory as well a pain reliever.

Drugs

• Painkillers

• Morphine is also a complicated amine that relives pain.

• Morphine blocks nerve receptors that register the sensation of pain.

• Codeine and heroin are forms of morphine.

Morphine

Works cited

• http://www.chem.ucalgary.ca/courses/351/Carey/Ch22/ch22-1.html#Nomenclature

• www.whfreeman.com/chemistryinyourlife • http://www.cem.msu.edu/~reusch/VirtualText/

amine1.htm

• www.amphetamines.com • Yahoo Images http://www.yahoo.com • Baird, Colin, Gloffke, Wendy. Chemistry in

Your Life. W.H. Freeman and Company. New York, 2002.