Amgen - CRUSH Report - 09B2

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Amgen Inc. 1 Amgen Center Drive Thousand Oaks, CA 91320-1799 Main: 805-447-1000 Fax: 805-447-1010 www.amgen.com Annual Revenues – $15.0 Billion Fiscal Year End – December Employees – 17,500 Ticker Symbol (NASDAQ) – AMGN Industry – Pharmaceuticals INFORMATION TECHNOLOGY HIGHLIGHTS

Enterprise Applications o ACT•1 Group managed services and human resource solutions o Ariba 8.1, Spend Management o Callidus TrueComp 3.7 sales performance management o CSC FirstDoc R&D 4.3, 6.0 o EMC Documentum o HP Peregrine Service Desk o IBM Lotus Notes, Mobile Notes o IBM MRO Maximo Enterprise Asset Management o Microsoft Exchange 2007 Enterprise Edition, Unified Messaging o Microsoft Outlook o Open Text Livelink Enterprise Content Management (ECM) o Oracle JD Edwards o Oracle Siebel Pharma Dynamic Sales, Customer Relationship Management

(CRM) o SAP R/3, ERP Central Component (ECC) 5.0, 6.0: Accounts Payable (AP),

Accounts Receivable (AR), Advanced Planner and Optimizer (APO), Asset Management (AM), Capable-to-Match (CTM) Planning, e-Recruit 6.0, Financial Accounting and Controlling (FI/CO), General Ledger (GL), Human Resources (HR), Human Capital Management (HCM), Livecache 7.6, Materials Management (MM), Organizational Management (OM), Performance Management (PM), Personnel Administration (PA), Project Systems (PS), Sales and Distribution (SD), Strategic Enterprise Management (SEM), Supplier Relationship Management (SRM) 4.0, Supply Chain Management (SCM) 5.0, Warehouse Management (WM),

o Smeadlink Integrated Document Management o Werum PAS-X Manufacturing Execution Systems (MES) 2.4 to 3.09

Data Management & Business Intelligence o Actuate business intelligence7.1, 8.1 o Brainware Data Solutions o Emerson DeltaV Digital Automation System o IBIM Informix o IBM Cognos for Business Intelligence (BI) and Data Warehousing (DW) o IBM Cognos PowerPlay Enterprise Server, Impromptu, IWR, Upfront

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o Informatica PowerCenter 7.1.2, 8.0 o Informatica PowerConnect for SAP ECC and BW 8.1.1 o Microsoft Access o Microsoft SQL Server 2000, 2005 o Oracle Database 9i, 10g o Oracle Hyperion Brio Intelligence 6.6 o Oracle Virtual Directory o Pegasystems Business Process Management Software Solutions o Rockwell Supervisory Control and Data Acquisition (SCADA) o SAP Content Server 6.4 o SAP NetWeaver Business Explorer (BEx) o SAP NetWeaver Business Information Warehouse (BW) o SAP NetWeaver Business Intelligence (BI) 3.5, 7.0 o SAP NetWeaver Mater Data Management (MDM) o SAS BASE 9.1.2, GRAPH, MACRO, STAT o Teradata o TIBCO 5.2

Hardware/OS/Systems Environment o Avaya Octel message servers o Bay Networks BCN Routers o Cisco 2800, 3600, 3800, 7200 series routers o Cisco Catalyst 2900, 3750, 6500 switches o Cisco CatOS o Cisco Content Services Switch (CSS) o Cisco Unified Messaging o Cisco Unified Wireless Network o HP Integrity rx2620 family servers o HP ProLiant DL385 high efficiency rack servers o IBM AS/400 o IBM iSeries o Microsoft Active Directory o Microsoft Business Desktop Deployment (BDD) 2007 o Microsoft Live Communications Server 2005 o Microsoft Windows Driver Kit (WDK) 5.3, 6.5 o Microsoft Windows NT, 2000, XP o Microsoft Windows Server 2003, XP o Microsoft Windows Terminal Server o NetApp filers, storage o Nortel Contivity 1000, 2500, 4000 VPN o Nortel PBX o Nortel Unified Messaging o Quantum Scalar i2000 tape library o Red Hat Linux o Sun Enterprise 3500, 4500, 6500, 220R, 420R, o Sun Fire V-Series servers o Sun Netra Carrier-Grade Server o Sun Solaris 8, 9 o Sun Ultra series

Web Services & Application Development o AJAX o Aldon Application Lifecycle Manager

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o Apache Ant, Tomcat 5.5 o BCD Catapult automated e-mail, portal o CA AllFusion ERwin 4.1 o Eclipse 5.5 o EMC Documentum Application Builder 5.3, WebTop o HP Mercury Quality Center o IBM Rational Rose, RequisitePro o J2EE o Java Database Connectivity (JDBC) o Java, JavaScript o Microsoft .NET Framework: ASP.NET, VB.NET o Microsoft ActiveX o Microsoft BizTalk o Microsoft C# o Microsoft Internet Information Services (IIS) o Microsoft Office SharePoint o Microsoft Visual Basic (VB) 6.0 o Microsoft Visual Basic Application o Microsoft Visual SourceSafe (VSS) o Microsoft/Sybase T-SQL o Oracle Applications Database o Oracle BEA Plumtree o Oracle BEA WebLogic 8.1 o Oracle PL/SQL o Perl, Windows Scripting Host o SAP Advanced Business application Programming (ABAP) o SAP Exchange Infrastructure (XI) Messaging o SAP NetWeaver Enterprise Portal: Internet Pricing and Configurator (IPC) o SAP TREX 7.0 search engine o SilkRoad Eprise Web Content Management o Sparx System Enterprise Architect 7.0 o Sun Java System Directory o Sun Java System Web Server 6.1

Networking, Management & Security o CA Concord Communications IT management o Captaris RightFax 8.0 o Cisco Aironet 1242G Wireless access point o Cisco CallManager VOIP 4.1, 6.0 o Cisco IP Contact Center (IPCC) Infrastructure o Cisco Unity o Cisco VoIP Telephony o Cisco Web-VPN o ExtraView bug tracking and issue management platform o Geomant Message Waiting Indicator (MWI) 2007 for Microsoft Exchange Server

20007 and Unified Messaging solutions o HP OpenView (replaced HP Peregrine Systems) o IBM Tivoli Access Manager Administrator o Infoblox IP Address Management o Intelex Safety Management System, iForms o Juniper NetScreen Secure Services Gateway Firewal (SSG) 540, 550, Security

Manager

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o Microsoft Virtual PC o NettApp Decru storage security o OSIsoft PI Data History o Raritan Command Center network monitoring o SAP Solution Manager o SAP Virsa compliance o Sendmail secure messaging infrastructure o Symantec Veritas NetBackup, Volume Manager o VMware virtualization

Other Technologies, Applications & Business Initiatives o Adobe Reader 7.00 o Amgen Biostatistics Department’s Submission Data File (SDF) System o Amgen Call Center based in Thousand Oaks, Calif. o Amgen Data Centers based in Thousand Oaks, Calif. and West Greenwich, R.I. o Amgen Global Enterprise Resource Planning Program Integration o Amgen Global Opinion Leader Engagement System Data Operations Lead,

CRM Application o Amgen Information Technology Facility – Juncos, Puerto Rico o Amgen Research and Design Strategic Operations Outsourced to India o Amgen’s in-house Competitive Intelligence Application o ARCHIBUS Total Infrastructure and Facilities Management o Autodesk AutoCAD o Commercial Programming Systems (CPS) IT hiring o CompuCom IT Reorganization Contracting o HP Mercury e-signature functionality development o IBM 5-year, $500 million Information Systems Infrastructure Services Contract o Information Technology Infrastructure Library (ITIL) o Jones Lang LaSalle Americas Facilities Management Services Contract o Kling Stubbins architecture engineering project consulting o Maynard consulting: Engineered Standards Implementation o Microsoft Office Live Meeting o Microsoft Office Suite, Vista o PointRoll Web Site development o Quest America Database Administration and Maintenance Services o SAP Global Trade Services (SAP GTS o Shelby Group Strategic Software Consulting o Software Development Life Cycle (SDLC) o Vision Soft IT asset management consulting

IT SPOTLIGHTS Global Enterprise Resource Planning Program Amgen implemented a Global Enterprise Resource Planning (G-ERP) Program to increase Amgen’s productivity and enable improved decision-making by creating new business processes that are global, standardized, cross-functional, and scalable. G-ERP is transforming approximately 800 business processes in the areas of Human Resource, Finance, Supply Chain, Procurement and Customer Order to Cash spanning 45 countries including North America, Europe, and Australia and more than 18,000 employees, using a single instance of SAP. There have been approximately 150

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Amgen staff members and 120 IBM consultants dedicated full-time to this program over the last 33 months. The G-ERP Program will allow Amgen to realize five key benefits:

• Improved data integrity and accuracy by creating a single source of information • Real-time access to information, enabling timely decision-making • Improved efficiency and scalability through automated business processes • Reduced effort to meet compliance requirements • Streamlined software portfolio, reducing maintenance costs.

As part of the G-ERP Program the SAP system is being completely integrated with 86 other Amgen core systems. Amgen decided to adopt the SAP NetWeaver platform together with the SAP Exchange Infrastructure to develop systems. They implemented SAP’s Human Resources module to standardized and automate existing HR processes and forms throughout the company including SAP’s E-Recruiting module which was introduced to support the way Amgen recruits talent globally. Amgen is one of the first SAP customers to make extensive usage of the SAP XI Messaging infrastructure to enable integration with other systems using a services oriented architecture (SOA). Further breakdown of the Global Enterprise Resource Planning Program in the IT Development section on Pages 10-13 or visit http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031 IBM Informat ion Systems Inf rast ructure Services Cont ract IBM has signed a five-year, $500 million deal with Amgen to provide IT services including computer networks, software, messaging systems, and help desk support. IBM could get an additional $300 million if three extension contracts are exercised. The agreement will impact about 100 Amgen employees and the Thousand Oaks, Calif.-based company’s 60-plus sites, Amgen spokesman David Polk said, adding that the affected employees will be given an opportunity to work with IBM. Kl ing Stubbins has worked on projects a re the fol lowing locat ions:

• Amgen AR6 Data Center design infrastructure build out – West Greenwich, RI. • Amgen Data Center upgrades – Thousand Oaks, Calif. • Amgen Information Technology Facility concept design – Thousand Oaks, Calif. • Amgen Information Technology Facility – Juncos, Puerto Rico.

Research and Des ign Strategic Operat ions Outsourced to India In 2006, under the gun to increase productivity, Amgen opened up affiliates in Mumbai and Hong Kong. Its Mumbai operation will support trials in India while Hong Kong’s serves as a regional hub for operations in East Asia. Amgen says it is “partnering with companies in India and China to support its R&D operations,” but won’t divulge what it’s investing in Asia. CompuCom IT Reorganizat ion Cont ract ing CompuCom was contracted to help reorganize part of the IT department to achieve optimal service and revenue generation. CompuCom contractors worked to troubleshoot and provide solutions for network bottlenecks and network slow downs, and provided solutions for end users by successfully assisting with hardware and software issues. Contractors worked with teams to initiate policies and procedures for inventory control, resulting in saving $150,000 in labor costs on a yearly basis, and increased assets by $250,000 by tracking inventory more efficiently. This radically increased customer service rating by developing and empowering the technical staff.

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Global IS Inf rast ructure St rategic Sourc ing Program A 54 person IT team transitioned the company’s global IS infrastructure functions, processes and employees the Amgen’s outsourcing vendors. This project had a total budget of $6 million. Global Unif ied Col laborat ion Deployment An Amgen in house team consisting of 13 team members worked with 3rd party vendors to design and implement Cisco’s Unified Messaging, e-faxing, and Instant Messaging into the Microsoft Exchange and Outlook environment. The project required collaboration with Legal, Compliance, Helpdesk and Training organizations to ensure effective operational support and avoid misuse of the new technology The project ran a budget of approximately $2.9 million and resulted in annual cost savings of approximately $1.44 million. Cisco Cal l Manager VoIP and IPCC (Contact Center ) Infrastructure Upgrade A team of eight infrastructure analysts made up the Cisco Technical Services team that performed the upgrade of Cisco Call Manager 4.1 to Call Manager 6.1. The upgrade provided enhanced functionality to the existing VoIP users and call center environments and ensured compatibility with the Unified Messaging solution. The project costs amounted to $600,000. Manufactur ing Data Management (MDM) Integra t ion A seven member project team integrated regulated data from 5 manufacturing source systems, including PI and WERUM PAS X, through a virtual data warehouse using the SAP ‘XMII’ platform. The solution provided consolidated, regulated Good Manufacturing Procedures (GMP) data reports for the entire product manufacturing process at each U.S. manufacturing facility. The project budget was approximately $688,000. Tier I I I Data Center and East Coast Regional Head Off ice IS Inf rastructure Implementat ion The tier III data center design and construction project had a budget of $4.9 million and a team of 18 analysts. The project tasks included:

• IS computer and server rooms • Network infrastructure (wired and wireless) implementation • Site cabling infrastructure (redundant fiber and copper) • Telephony and voicemail systems • Cabling offices, cubes, Audio Visual (A/V) conferencing systems

Data Cent Upgrades and Server Relocat ion The project had a budget over $200,000 in which a team of 10 analysts managed the IS activities for the new construction and upgrade of data centers. They provided highly reliable, fault tolerant (n+1), and scaleable environments (Tier II/III) for hosting business critical systems. The team relocated over 250 servers between data centers, re-qualification, and validation with ITIL based change management processes. Enterpr ise Workflow Management System Development and Ma intenance Project Beginning in 2008, this project deals with the design and development of enterprise workflow management systems. The workflow management system manages the different phases through which an Issue or a Tracking record traverses, before it gets final status. Commercial Off the Shelf (COTS) solution ExtraView is used for defining and managing the workflows. The ExtraView is a metadata driven J2EE application with Java extensions using UserCustom classes. Technologies and tools used during this project include Java, J2EE, HTML, JavaScript, AJAX, JDBC, Windows, Active Directory, LDAP Browser, Oracle BEA WebLogic 9.2, Apache Tomcat 5.5, Oracle Database 10g, Eclipse 3.4.1, ExtraView, UML, Sparx Enterprise Architect 7.0, Unix and Shell scripting.

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Global Opin ion Leader Engagement (GOLE) and CRM Applicat ion The Global Opinion Leader Engagement (GOLE) solution provides a single repository and approach for sharing information about who Amgen’s opinion leaders are and how these individuals are being engaged across the company. The GOLE Operation teams were responsible for providing first line support to maintain steady state operations of the Global Opinion Leader application and associated environments. They designed and developed the GOLE Application using .Net and J2EE technology. The team managed the data base extract processes and designed DTS to extract external data. The technology environment of this project was comprised of VB.Net, ASP.Net, C#, SQL server, Oracle Database 10g, PL/SQL, Oracle 9i Client, XML, XSD, Java and J2EE. BUSINESS INFORMATION Amgen Inc., incorporated in 1980, is a biotechnology company that discovers, develops, manufactures and markets human therapeutics-based on advances in cellular and molecular biology. The company operates in human therapeutics. It markets human therapeutic products in the areas of supportive cancer care, nephrology, and inflammation. Its principal products include Aranesp (darbepoetin alfa), EPOGEN (Epoetin alfa), Neulasta (pegfilgrastim), NEUPOGEN (Filgrastim) and Enbrel (etanercept). Aranesp and EPOGEN stimulate the production of red blood cells to treat anemia and belong to a class of drugs referred to as erythropoiesis-stimulating agents (ESAs). On Jan. 4, 2008, the company completed the acquisition of Dompe Biotec, S.p.A. Aranesp is used for the treatment of anemia both in supportive cancer care and in nephrology. EPOGEN is used to treat anemia associated with chronic renal failure (CRF). Neulasta and NEUPOGEN selectively stimulate the production of neutrophils, one type of white blood cell that helps the body fight infections. ENBREL blocks the biologic activity of tumor necrosis factor (TNF) by inhibiting its binding to TNF receptors, a substance induced in response to inflammatory and immunological responses, such as rheumatoid arthritis and psoriasis. During the year ended Dec. 31, 2008, its principal products represented 94 percent of total product sales. The company maintains sales and marketing forces primarily in the United States, Europe and Canada. It markets its products to healthcare providers, including physicians or their clinics, dialysis centers, hospitals and pharmacies. It markets ENBREL under a co-promotion agreement with Wyeth in the United States and Canada (Joint Ventures and Business Relationships-Wyeth). In addition, it has entered into licensing and/or co-promotion agreements to market its products in certain geographic areas. In the United States, the company sells primarily to wholesale distributors of pharmaceutical products. Outside the United States, it sells principally to hospitals and/or wholesalers depending upon the distribution practice in each country. The company focuses its research and development (R&D) efforts on therapeutics for the treatment of grievous illness in the core areas of oncology, inflammation, bone, metabolic disorders and neuroscience. Its research takes a modality-independent approach to drug discovery, in which it chooses the possible approach to block a specific disease process before considering the type of drug (modality) that may be required to pursue that approach. It studies molecules across a range of modalities in the areas of proteins (sometimes referred to as large molecules), including monoclonal antibodies and peptibodies, and small molecules. It has major R&D centers in several locations throughout the United States and in the United Kingdom, as well as, smaller R&D centers in certain other countries throughout the world.

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The company’s manufacturing operations consist of bulk manufacturing, formulation, fill and finish activities, which produce Aranesp, Epoetin alfa, Neulasta, NEUPOGEN, ENBREL and other marketed products and product candidates for both commercial and clinical purposes. It operates commercial and clinical manufacturing facilities in several locations throughout the United States and in Puerto Rico, as well as performs certain finishing activities in the Netherlands. Third-party contractors manufacture some or all of certain of its marketed products and/or product candidates. Aranesp Aranesp is the company’s registered trademark for one of its erythropoiesis-stimulating proteins, a protein that stimulates red blood cell production. The company was granted a license by Kirin-Amgen, Inc. (KA), a joint venture between Kirin Holdings Company, Limited (Kirin) and Amgen, to manufacture and market darbepoetin alfa in the United States, all European countries, Canada, Australia, New Zealand, Mexico, all Central and South American countries and certain countries in Central Asia, North Africa and the Middle East. It markets Aranesp primarily in the United States and Europe. Darbepoetin alfa is also marketed under the brand name Nespo in Italy. EPOGEN EPOGEN is the company’s registered trademark for its recombinant human erythropoietin product, a protein that stimulates red blood cell production. It was granted a license to manufacture and market recombinant human erythropoietin in the United States under a licensing agreement with KA. The company markets EPOGEN for the treatment of anemic adult and pediatric patients with CRF who are on dialysis. Neulasta (pegfi lgrast im)/NEUPOGEN (Fi lgrast im) Neulasta is its registered trademark for a pegylated protein that selectively stimulates production of certain white blood cells known as neutrophils and is based on the Filgrastim molecule. It markets Neulasta and NEUPOGEN primarily in the United States and Europe. NEUPOGEN is the company’s registered trademark for its recombinant-methionyl human granulocyte colony-stimulating factor (G-CSF), a protein that selectively stimulates production of of neutrophils. It markets NEUPOGEN primarily in the United States, Europe and Canada. Filgrastim is marketed under the brand name GRANULOKINE in Italy. Filgrastim is also marketed under the brand name GRANULOKINE in Italy. Enbrel ENBREL is the company’s registered trademark for its TNF receptor fusion protein that inhibits the binding to TNF receptors, which can result in a significant reduction in inflammatory activity. It markets ENBREL under a co-promotion agreement with Wyeth in the United States and Canada. Other The company’s other marketed products comprises Sensipar (cinacalcet), Vectibix (panitumumab) and Nplate (romiplostim). Sensipar is the company’s registered trademark in the United States and Mimpara is its registered trademark in Europe, for the company’s first small molecule medicine used in treating CKD patients on dialysis who produce too much parathyroid hormone, a condition known as secondary hyperparathyroidism. Vectibix is the company’s trademark for its first entirely human monoclonal antibody for the treatment of patients with Epidermal Growth Factor Receptors (EGFr) expressing metastatic colorectal cancer (mCRC) after disease progression on, or following fluoropyrimidine-, oxaliplatin- and irinotecan- containing chemotherapy regimens. On Aug. 22, 2008, the Food and Drug Administration of Untied States (FDA) approved Nplate, the platelet producer for the treatment of thrombocytopenia in splenectomized (spleen removed) and non-splenectomized adults with chronic immune thrombocytopenic purpura (ITP). Nplate, the FDA approved peptibody protein, works by raising and sustaining platelet counts. On Feb. 6, 2009, the company announced that the European Commission granted marketing authorization for Nplate for

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the treatment of splenectomized adult chronic ITP patients who are refractory to other treatments (such as corticosteroids, immunoglobulins). The company competes with Johnson & Johnson, Hospira Enterprise B.V., Stada Arzneimittel AG, Sandoz GmbH, Hexal Biotech Forschungs GmbH, Medice Arzneimittel Putter GmbH & Co. KG, F.Hoffmann-La Roche Ltd., Shire Pharmaceutical Group Plc, Bayer HealthCare Pharmaceuticals, Chugai Pharmaceuticals Co., Ltd., Sanofi-Aventis Novartis AG, Ratiopharm, CT Arzneimittel, Teva, Procter & Gamble, Eli Lilly and Company, Merck & Company, Inc., Centocor, Inc., Schering Plough Corporation, Abbott Laboratories, Duramed Pharmaceuticals, Inc., DAVA Pharmaceuticals, Inc., Genentech, Inc., Biogen IDEC Inc., Genzyme Corporation and Connetics Corporation. EARNINGS CALL TRANSCRIPT Kevin Sharer, Chairman and Chief Executive Officer – April 23, 2009. We all know we are in the midst of the most challenging economic environment in 80 years. We also now know that for the first time the biopharmaceutical industry is not exempt from these economic factors in the United States. In America patients are sometimes postponing doctor visits, not always taking medicines on the prescribed schedule and in some cases, particularly Enbrel in our case, are finding the co-pays difficult to afford. We also know that health and insurance coverage is not as broad or robust as in prior non-recessionary years. We will talk about these factors later in the call, with particular emphasis on the aggressive steps we are taking to help patients afford their medicines. Now, I would like to focus on the first quarter revenue and our perspective about the rest of the year. It is a normal cyclical pattern at Amgen to have the fourth quarter be stronger than the first. For example, in both 2007 and 2008 the first quarter revenue was 4 percent below the prior fourth quarter. This year the difference is 12 percent. Looking more deeply, in both 2007 and 2008s first quarter demand was down approximately $147 million from the prior quarter. This year demand is down about $214 million fourth quarter to first quarter, with the difference between this and prior years numbers due to negative Enbrel trends. We also experienced an inventory swing fourth quarter ‘08 to first quarter ‘09 of $176 million, that is we were up $61 million fourth quarter ‘08 and down $115 million in Q109 that accounts, along with the Enbrel drop, for the vast majority of the total quarterly drop in revenue. Clearly Enbrel is a major challenge and George will provide more detail later. Our revenue plan is the basis for our revenue guidance and I will now put my view of our business in a context of our plan. Our international business is strong, doing well against biosimilars, and should be on or above plan for the year. While EPOGEN is a bit behind plan to date, we expect dose recovery and a modest price increase to help it achieve budget for the year. http://seekingalpha.com/article/132813-amgen-inc-f1q09earnings-call-transcript?page=-1 STRATEGY Amgen’s strategy includes putting patients first, focusing solely on human therapeutics, investing heavily in their pipeline, fostering a high-performing and diverse workforce grounded in their values, remaining independent by delivering superior value to their stockholders, and striving to be a leader in every therapeutic area they serve.

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On Aug. 15, 2007, they announced a plan to restructure their worldwide operations in order to improve their cost structure while continuing to make significant R&D investments and build the framework for their future growth. Through Dec. 31, 2008, they have completed substantially all of the actions initially included in their restructuring plan, including the divestiture of certain less significant marketed products discussed below. During 2008, they identified certain additional initiatives designed to further assist in improving their cost structure, including outsourcing certain non-core business functions, most notably certain of their information systems’ infrastructure services, as well as abandoning leases for certain additional facilities that will no longer be used in their operations. As part of the restructuring plan, they reduced staff, made changes to certain capital projects, closed certain production operations and abandoned leases primarily for certain R&D facilities that will not be used in their operations. IT EXPENDITURES Capital expenditures totaled $672, $1.3 billion, and $1.2 billion for the years 2008, 2007, and 2006, respectively. Capital expenditures for the three years were primarily associated with manufacturing capacity expansions and other site developments and investment in the company’s global ERP system and other information systems projects. They estimate 2009 spending on capital projects and equipment to be approximately $700 million. Selling, general and administrative expenses totaled $3.8 billion, $3.4 billion, and $3.4 billion for the years 2008, 2007, and 2006, respectively. During 2008, they identified certain additional initiatives designed to further assist in improving their cost structure, including outsourcing certain non-core business functions, most notably certain of their information systems’ infrastructure services, as well as abandoning leases for certain additional facilities that will no longer be used in their operations. The estimated cost of these additional initiatives is $95 million to $135 million. The total charges currently estimated to be incurred in connection with their restructuring plan, including related implementation costs, is $950 million to $985 million. Through Dec. 31, 2008, they have incurred $887 million of these costs and currently estimate that all remaining costs will be substantially incurred in 2009. IT DEVELOPMENTS

Global Enterprise Resource Planning Program, SAP, ECC 5.0: Supplie r Relat ionship Management (SRM) 4.0, E-Recruit 6.0, cFolders 3.10, SCM 5.0, IPC 4, Strategic Enterpr ise Management (SEM), CTM 5.0; SAP NetWeaver 7.0, Enterpr ise Portal (EP) 6.0, Business Informat ion Warehouse (BW) 7.0; SAP Content Server 6.4, XI 3.0, Livecache 7.6, TREX 7.0, Solut ion Manager 4.0, Global Trade System (GTS) 7.0; Adobe 7.00; Informat ica PowerConnect Integrat ion for ECC and BW; TIBCO 5.2; Mic rosoft SQL Server 2005, Windows Server 2003 Amgen implemented a Global Enterprise Resource Planning (G-ERP) Program to increase Amgen’s productivity and enable improved decision-making by creating new business

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processes that are global, standardized, cross-functional, and scalable. The G-ERP Program will allow Amgen to realize five key benefits:

• Improved data integrity and accuracy by creating a single source of information • Real-time access to information, enabling timely decision-making • Improved efficiency and scalability through automated business processes • Reduced effort to meet compliance requirements • Streamlined software portfolio, reducing maintenance costs.

G-ERP is transforming 800 business processes in the areas of Human Resource, Finance, Supply Chain, Procurement and Customer Order to Cash spanning 45 countries (North America, Europe, Australia) and more than 18,000 employees, using a single instance of SAP. There have been approximately 150 Amgen staff members and 120 IBM consultants dedicated full-time to this program over the last 33 months. Usage of technology (infrastructure, software, network, etc.) has been a key component of the G-ERP Program. The ERP solution includes the implementation of nearly all modules of SAP using a single “instance” in production to support Amgen globally that serves as a foundation for the process and efficiency improvements needed to better ensure uninterrupted patient supply. The software components included as part of the ERP solution include:

• Within SAP: SAP NetWeaver 7.0, ECC 5.0, GTS 7.0, SRM 4.0, eRecruit 6.0, cFolders 3.10, SM (Solution Manager) 4.0, SCM/APO 5.0, IPC 4, BW 7.0, SEM, Livecache 7.6, CTM (APO optimizer) 5.0, Content Server 6.4, XI 3.0, EP 6.0, TREX 7.0

• Outside of SAP: Adobe 7.00, Informatica PowerConnect Integration (for ECC v7.1.4, for BW v8.1.1), TIBCO 5.2, Microsoft SQL Server 2005 and OS Windows Server 2003

(Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

Global Enterprise Resource Planning Program Integrat ion, SAP NetWeaver, SAP Exchange Inf rastructure, Solut ion Manager, HP Mercury Qual it y Center, Vi rsa , Cranberry Back Off ice System As part of the G-ERP Program the SAP system is being completely integrated with 86 other Amgen core systems. Amgen decided to adopt the SAP NetWeaver platform together with the SAP Exchange Infrastructure to develop systems. In addition to the technology components used as part of the ERP solution, technology (usage of different tools) was important to better manage the program processes and documentation. Some of the key tools used at Amgen for the G-ERP Program include:

• SAP Solution Manager (SolMan) – managed ‘in process’ project documentation (e.g., design specifications, process flows, configuration documentation, data conversion protocols); was also used to manage the transport process of code and configuration to the various system environments (e.g., from Development to Integration Test, Operation Qualification, Staging, Training, Production)

• Mercury/HP Quality Center (QC) – served as the repository for User Requirements. Test documentation (e.g., Test scripts, defects). Was leveraged heavily by the program management team to manage the testing process (with real-time status/metrics reporting). QC also serves as the repository for the ‘traceability matrix’ which is a required deliverable for FDA Computer System Validation.

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• Virsa – manages SAP security roles and flags any segregation of duties violations and risks.

• Back Office System ‘Cranberry’ tool – improved data conversion process by enabling a more streamlined way to extract, adjust, upload and reconcile data being loaded into SAP

Amgen architected the G-ERP system infrastructure to enable Disaster Recovery (data replication across multiple locations). Amgen performed failover and failback tests that were very successful. This DR solution gives Amgen a Recovery Point Objective (RPO = how much data they will lose in case of a disaster) of zero and a Recovery Time Objective (RTO = how long it will take to be back up and running) of 4 hours. This further reduces improves Amgen’s ability to ensure uninterrupted patient supply. (Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

Global Enterprise Resource Planning Program, SAP Human Resources Module Amgen implemented SAP’s Human Resources module to standardized and automate existing HR processes and forms throughout the company. The G-ERP system is used by every Amgen employee in the company for performance objectives/reviews and updating their some personnel-related information using the self-service portal. All Amgen staff now has a central place to find their position history and salary history on-line. Staff also now has access to all of their (current and historical) performance reviews and leverage as appropriate for professional development and future performance reviews, saving both time and effort. (Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

Global Enterprise Resource Planning Program, SAP E-Recruit ing Module SAP’s E-Recruiting module was introduced to support the way Amgen recruits talent globally. The applicant tracking system allows Amgen’s Human Resources department to manage the processing of applicants and track their progression. Additionally, having a global applicant tracking system gives visibility into all recruiting and hiring across Amgen. E-Recruiting also supports internal movement within Amgen. “E-Recruiting will assist us in gaining access to potential candidates globally and increase our efficiency in the management of these candidates,” said Jill Rogers Executive Director, HR. “The launch was very smooth – in fact, we were able to handle record volumes the day after go-live. I deeply appreciate the hard work by so many around the world to make this happen,” said Rolf Hoffman, then Senior Vice President, International Commercial Operations for Amgen. (Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

Global Enterprise Resource Planning Program, SAP XI Messaging Infrastructure Amgen is one of the first SAP customers to make extensive usage of the SAP XI Messaging infrastructure to enable integration with other systems using a Services Oriented Architecture (SOA). In the case where SAP needs to send data to other Amgen systems, master data and transactional is exposed via pull-based query interfaces directly from SAP using BI reports, ECC Reports, or Amgen’s Enterprise Data Hub (EDH) utilizing common Web services via SAP XI. (Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

Global Enterprise Resource Planning Program, HP Mercury Qual ity Center, e-Signature Amgen operates in a highly regulated environment. In order to best leverage the global team Amgen leveraged an automated testing tool, Mercury Quality Center. There were two aspects of

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Amgen’s usage of QC which are unique, both of which required custom development by Mercury Interactive to enable the new functionality which has only been done for Amgen.

• e-Signature: In order to be 21 CFR Part 11 compliant (a requirement of FDA Computer System Validation), Amgen asked Mercury Interactive to build in electronic signature functionality (to replace a wet-ink signature on a hard copy test script). This significantly reduced effort, cost and time during the testing process as compared to other SAP implementations at Life Sciences companies. With the broad functional and geographic scope of the G-ERP program and high volume of Qualification test scripts (>3,000 for Global HCM/Europe and >5,000 for North America), the testing process would have been significantly delayed if the G-ERP team used the manual test documentation approach (e.g., Fed Ex’ing test scripts back an forth between the US & Europe for wet-ink signatures upon completion of each test step in the 80 step script).

• Traceability Matrix: This is a required deliverable as part of FDA Computer System Validation. Amgen asked Mercury Interactive to build in a ‘link’ between the User Requirement and Test objects so that the Traceability matrix would be made available on-line and real-time (vs. needing to maintain manually in a separate document like MS Word, Excel which is how most other Life Sciences have documented their Traceability matrix).

(Case study dated 2008.) http://www.cwhonors.org/viewCaseStudy2008.asp?NominationID=2031

IBM Informat ion Systems Inf rast ructure Services Cont ract In 2008, IBM signed a deal worth up to $800 million to provide information systems infrastructure services to Amgen. IBM’s work will span services such as networks, help desk support, servers hosting applications and electronic messaging systems under the deal that could climb to $800 million if Amgen extends the contract’s terms by three years, according to a filing Amgen made with the Securities and Exchange Commission. The agreement will impact about 100 Amgen employees and the Thousand Oaks, Calif.-based company’s 60-plus sites, Amgen then spokesman David Polk said, adding that the affected employees will be given an opportunity to work with IBM. http://www.metrodenver.org/news-center/metro-denver-news/IBM-Amgen.html

Amgen Submission Data Fi le (SDF) System, SAS, Java, and Oracle A number of years in the making, the SDF System represents the most ambitious software development project ever undertaken within the Biostatistics Department at Amgen. From its inception it was designed to tackle many of the difficulties that have plagued statistical programming ever since the first programs were developed to analyze clinical trial data. The system scope includes the following areas:

• Automating front-end and back-end data security. • Providing rapid access to raw and derived datasets to all sites within the organization. • Implementing large-scale systems design and software engineering principles in the

clinical trials programming domain to reduce the software development effort required for each statistical analysis.

• Modeling the complex relationships inherent within clinical data to provide sophisticated impact analysis tools with the capability to manage and cascade change.

• Implementing an object-oriented (OO) approach to the definition and reuse of clinical data standards.

• Improving review and quality control processes by coupling the specification of a program together with its source code to create one logical entity.

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• Reducing the validation burden (through large-scale reuse) while at the same time increasing overall quality.

The Submission Data File System (SDF) was designed to support the development, validation, maintenance and execution of SAS programs required to create Submission Data Files (SDFs). The system leverages a number of key technologies including SAS, Java, and Oracle. (Article dated 2006.) http://www.lexjansen.com/phuse/2006/ad/ad12.pdf

Jones Lang LaSa l le Amer icas Faci l i t ies Management Services Contract In 2009, Amgen signed an outsourcing agreement with Jones Lang LaSalle Americas for facilities management services. The facilities services contract applies to Amgen’s 11 North American sites, with most of the effect on facilities staff in Thousand Oaks, Calif., said company then spokesman David Polk. The company entered into a 5-year contract worth $500 million, Amgen reported in a filing with the U.S. Securities and Exchange Commission on Feb. 10. That contract includes services such as building and facilities maintenance, food services, waste disposal and recycling, inventory management of related supplies, utilities systems maintenance, and other projects. http://www.renalbusiness.com/hotnews/amgen-to-layoff-150-workers--outsource-facili.html

Outsourcing Research and Design Strategic Operat ions to India In 2006, under the gun to increase productivity, Amgen opened up affiliates in Mumbai and Hong Kong. “Amgen is embarking on the single greatest R&D expansion since the company’s founding in 1980,” declares Kevin Stark, former senior director, R&D Strategic Operations at Amgen. Mr. Stark says the company is adding new clinical capabilities around the world to keep up with what he calls Amgen’s robust pipeline. Its Mumbai operation will support trials in India while Hong Kong’s serves as a regional hub for operations in East Asia. Amgen says it is “partnering with companies in India and China to support its R&D operations,” but won’t divulge what it’s investing in Asia. http://www.redherring.com/Home/20098

Microsoft SharePoint The following is an excerpt from a blog post dated 2009: “Deploying software applications in a business driven organization is always a challenge. Here at Amgen we have started using Microsoft SharePoint as a way to increase peer-to-peer collaboration within large application deployment projects. Although still in the initial stages, we have experienced faster information sharing and better team convergence on new business processes. We are also working with secure Web content management service providers and our experience is that they can actually deliver on the promise of paperless document sharing with the added features of security and CFR 21 compliance.” http://www.the-corner-office.com/2009/03/Web-20-business-service-erp-programs/

ARCHIBUS Total Infrastructure and Faci l i t ies Management, Autodesk AutoCAD Amgen selected ARCHIBUS “for its predefined schema, flexibility, and compatibility with AutoCAD.” The company was experiencing rapid expansion, particularly with the acquisition of Synergen in Boulder, Colo. Several scientists needed to be moved to Amgen’s headquarters in Thousand Oaks, Calif. Several others needed to be moved to Boulder. Relocating staff and reconfiguring space have been greatly facilitated by the CAFM system. Maintaining the system in the face of a 30 percent churn rate has been simplified by having human resources information downloaded automatically into the ARCHIBUS database. (Article dated 2005.) http://www.archibus.com/success/success_story.cfm?ssid=77

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Amgen Lean Business Strategy Amgen developed a lean deployment strategy that took into consideration the relative youth of biotechnology, Amgen’s unique culture, and the recommendations of Lean experts. The team showed several million dollars in savings in the first six months and created enough positive momentum to widen the net in year two. (Article dated 2006.) http://www.qimacros.com/pdf/pharmabrochure.pdf

PharmiWeb HospitalPharma.com Collaborat ive Pharmaceut ical Portal HospitalPharma.com, a new collaborative portal built by PharmiWeb Solutions, offers fast access to details on a wide range of pharmaceutical products. Hospital pharmacists can see price and prescribing information and then place orders, all through their desktop PC, via a standard Internet browser. The system also gives pharmaceutical companies a way to improve customer service without the cost of building and maintaining their own on-line systems. Amgen contracted to use the site in 2003. Paul Greenland, Business Unit Director of Amgen commented: “We believe that this effective online channel for information, sales and support, will play a key role in helping us reach and support our secondary and tertiary care customer base” (Article dated 2003.) http://www.microsoft.com/uk/press/content/presscentre/releases/2003/06/pr03084.mspx

SAP Supplier Relat ionship Management (SRM) 4.0, Ar iba 8.1, Spend Management, She lby Group St rategic Software Consult ing Amgen employs two eProcurement systems covering worldwide indirect procurement. SAP/SRM 4.0 is used for all indirect procurement at Amgen’s European and Asia Pacific sites and for selected project related procurement activities in North America. Ariba 8.1 is used only at Amgen’s North American facilities for all remaining indirect procurement. With upgrades imminent for both SAP SRM and Ariba Spend Management, Amgen wanted to look closely at eProcurement in both new platforms to determine the optimal future strategy and direction of eProcurement. As a result, The Shelby Group was engaged to perform a strategic software assessment, which included an analysis of the financial viability of each software company, future product functionality, procurement best practices, software upgrade/implementation costs, and Return on Investment (ROI). (Undated case study.) http://www.theshelbygroup.com/client_success_amgen.html

Amgen Data Center Locat ions Design firm Kling Stubbins lists the following Amgen projects, along with their locations, in its portfolio:

• Amgen AR6 Data Center design infrastructure build out – West Greenwich, RI. • Amgen Data Center upgrades – Thousand Oaks, Calif. • Amgen Information Technology Facility concept design – Thousand Oaks, Calif. • Amgen Information Technology Facility – Juncos, Puerto Rico.

http://www.klingstubbins.com/clientlist/clientlist_mission_critical.html

Maynard Consult ing: Engineered Standards Implementat ion To manage a rapidly evolving pipeline of new products effectively, Amgen recognized that developing new tools would not only help manage manufacturing capacity but would also support the continued success of its existing and new products. Amgen contracted H. B. Maynard and Company, Inc., an industrial engineering consulting firm, to facilitate the project. A cross-functional team of Amgen staff members and Maynard consultants was formed to

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combine traditional and modern industrial engineering techniques to improve labor utilization, improve workflow, and increase overall output capacity. (Undated article.) http://www.hbmaynard.com/ClientArticles/CSUpdate3.asp

Windows 2003 Act ive Di rectory, NT 4.0 Amgen hired the Active Directory, NIS+, and LDAP Architects from Structure Networks to perform the overall design, testing/validation, deployment and migration to a parallel Windows 2003 Active Directory infrastructure for over 18,000 users located at over 40 sites in North America, Europe, and Asia. Structure Networks also helped develop the strategy for migrating user accounts, security groups, client workstations and application servers from over 45 NT 4.0 domains to the Windows 2003 Active Directory infrastructure. (Undated case study.) http://www.structurenetworks.com/content.aspx?x=about_casestudies

Aldon Appl icat ion Lifecyc le Manager, IBM iSeries, AS/400 Amgen must comply with strict FDA regulations, including the requirement to document and track all changes made to the AS/400 or iSeries systems and software. To help manage that process, Amgen uses Aldon Lifecycle Manager for iSeries, Aldon’s change management solution. The iSeries plays a crucial role in Amgen’s operations, running business applications ranging from financial management to manufacturing to sales and order processing. Amgen currently has three iSeries machines located in its corporate offices in Thousand Oaks. (Undated case study. Registration required for full article.) http://whitepapers.techrepublic.com.com/abstract.aspx?docid=167114

Quest America Database Administrat ion and Maintenance Services, Oracle Applicat ions Database, NT infrastructure Quest America is a CMMI Level 2, global full service Information Technology services firm that provides solutions through strategy, consulting, and outsourcing. The company provides database administration and maintenance services for Amgen’s Oracle Applications database on an NT infrastructure, with managed services SLA’s to ensure application uptime and reliability. (Undated article.) http://www.questam.com/success.htm

GlassHouse Technologies IT Infrastructure Consult ing GlassHouse Technologies is an independent IT infrastructure consulting and services firm focused on transforming IT environments to a service provider model. Transom SM, GlassHouse’s proprietary methodology, aligns business processes and information technology systems, transforming our clients’ existing infrastructures into scalable, compliant, cost-efficient and tightly organized environments. In 2007, Glasshouse listed Amgen as a customer. http://news.thomasnet.com/companystory/534232

Oracle Siebel Pharma Dynamic Sales Oracle’s Siebel Pharma Dynamic Sales was specifically designed to meet the unique needs of the pharmaceutical and biotechnology industries. The application provides functionality for field sales and management, telesales, national accounts, medical affairs, customer service, and marketing organizations. Using built-in, easy-to-use analytics, the Siebel Pharma Dynamic Sales solution leverages customer and market intelligence gathered from multiple sources to better target physicians and maximize sales impact. Oracle listed Amgen as a customer of the Siebel solution in 2006. http://www.oracle.com/industries/life_sciences/siebel-pharma-dynamic-wp.pdf

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Brainware Data Solut ions Brainware helps companies automatically extract, process, and retrieve data from any source. Their Data Capture solutions virtually eliminate manual data entry while their Enterprise Search solutions allow customers to locate required data more rapidly. Brainware listed Amgen as a customer. https://www.examiner.com/p-330768~Premier_Oracle_Publication_Features_Brainware_Customer_Success_Story.html

BCD Catapult , iSeries Business Computer Design Int’l Inc. Catapult, the automated e-mail, portal and iSeries report distribution system, is utilized by Amgen. (Listed in 2004.) http://search400.techtarget.com/originalContent/0,289142,sid3_gci950787,00.html

Intelex Safety Management System, iForms The Intelex Safety Management System is a Web-based software application that enables companies to practice pro-active and reactive safety management. Amgen uses Intelex Safety Management System with iForms. http://www.intelex.com/Manufacturing-28clients.aspx

Pegasystems Business Process Management Software Solut ions Pegasystems provides Business Process Management (BPM) software solutions. They help organizations to achieve new levels of agility, become more competitive, and innovate. Pegasystems lists Amgen as a customer. http://www.pega.com/AboutPega/Customers/customer_detail.asp?c=11

Sun and Informix Solut ions Sun and Informix solutions:

• Solve operational problems and removing cost inefficiencies. • Identify areas of business that need attention, and helping you determine what kind of

attention they need. • Enable companies to better understand their customers and their buying habits. • Assist customers in running a more streamlined and profitable business.

Sun listed Amgen as a customer in 1999. http://www.sun.com/third-party/dw/brochures/Sun_and_Informix_for_BI.pdf

IT EXECUTIVES Tom Flanagan, Senior Vice Pres ident and Chief Informat ion Off icer

Tom Flanagan became senior vice president and CIO in September 2006. Prior to that, he led Amgen’s Global ERP program since February 2005. He joined Amgen in June 2004 as vice president, Information Systems. Prior to joining Amgen, Flanagan spent eight years at MCI, where he served in a variety of executive capacities, including CIO and senior vice president of Global Service Delivery. Before joining MCI in December 1995, Flanagan spent 24 years as an officer in the

United States Navy. Flanagan is a graduate of the U.S. Naval Academy, MIT, U.S. Naval War College, and Harvard University’s John F. Kennedy School of Government. http://www.amgen.com/about/leadership_team_tom_flanagan.html

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Peter Flack, Di rector, Informat ion Systems Infrastructure Peter is currently serving two roles in Amgen’s Information Systems organization. He is accountable for Amgen’s data centers and computer rooms globally, where he is responsible for establishing a governance model for managing and operating these facilities as an enterprise resource. Peter is also a member of Amgen’s Global ERP Program Operations management team, focused on infrastructure architecture and deployment. Peter has been with Amgen for three years in various management roles focusing on infrastructure management and deployment. http://agendabuilder.gartner.com/lsc26/WebPages/SessionList.aspx?Speaker=1636 CRUSH Alerts – Sales Triggers

SalesQuest is capable of delivering up-to-the-minute sales trigger alerts on your target accounts, industries and territories in a single, easy-to-read daily e-mail. For more information on how CRUSH Alerts can help increase productivity, save time, accelerate sales cycles and ensure that you don’t miss out on any sales opportunities, please contact a SalesQuest representative at (978) 975-1111, ext. 102.

MILESTONES 2009

May – Announced that it would lay off 101 workers at its drug-manufacturing site in Bothell, Wash. between July 13 and July 27, 2009.

2008

July – Amgen and Ortho Biotech settled antitrust suit.

June – Named Anna Richo Senior Vice President of Worldwide Compliance.

2007

August – Named Dr. Fabrizio Bonanni as head of Operations.

July – Completed acquisition of Ilypsa.

July – Completes acquisition of Alantos.

May – Named David Lacey, M.D., Senior Vice President, Head of Research.

April – Appointed Robert Bradway as Executive Vice President and Chief Financial Officer.

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Commentary f rom a Senior Business Analyst based in Juncos, Puerto Rico. The team performs business process analysis, system upgrades and improvements, change control, project management, computer system validations, non-conformance investigations, and report generation using query tools such as Cognos Impromptu and Showcase. Projects performed include the following: Werum PAS-X 2.4 to 3.09 Team members performed gap analysis and master data management for an upgrade from version 2.4 to 3.09. The project involved analyzing and implementing business modifications utilized in the existing version into the new version. ERP Implementation (SAP) As part of this global project, the team managed data conversions from the ERP JDEdwards system into SAP. Group members translated business requirements into technical requirements, developed test scripts, and performed troubleshooting. OSISoft Plant Information (PI) and RtReports. The team administered the SCADA system at a bulk manufacturing plant at the site. Group responsibilities included translating business requirements/design into technical requirements/design, managing work orders and validation documents, training users on the RtReports application, and modifying system components. Oracle JD Edwards Single Instance Project. Group members participated in a global initiative to merge several databases from the ERP JD Edwards system into a single instance. They developed initial conversion programs for the merger of the data. Commentary f rom an Informat ion Systems Manager based in Thousand Oaks, Cal i f . The Thousand Oaks technical team is tasked with implementing and supporting sales force incentive compensation and corporate competitive intelligence systems. They work closely with the business client (sales operations) to drive and streamline incentive compensation processes and procedures to meet overall corporate strategic goals and major product launches on time. Additional responsibilities include:

• Partnering with the business client (business analytics and information group) to implement and support the competitive intelligence business system to achieve business marketing objectives and adhering to internally approved IS and business standards.

• Serving as technical experts of the Callidus TrueComp Suite, Actuate and Informatica technologies used in the incentive compensation processes, and integrating applications to use corporate directory services, Sun One Directory Server, and WebLogic Application Server.

• Performing technological gap analysis, system upgrade assessments and technical feasibility of new technologies to enable smooth integration with existing processes. Working with the vendors to incorporate custom code that enhances product functionalities to meet Amgen business needs.

• Performing project management activities, which include work effort estimation, resource allocation, budget preparation, client management and vendor relationship management.

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• Ensuring that all the compliance and approvals are met as per systems and audit guidelines. The team led the TrueComp upgrade from version 3.7 to 5.1 and the assessment exercise. The hardware and software environment includes Informatica PowerCenter 7.1.2, 8.0; Actuate 7.1, 8.1; Oracle Database 9i, 10g; Microsoft SQL Server 2005; Callidus’ TrueComp 3.7 Suite, Sun Java System Web Server 6.1; Oracle PL/SQL, BEA Weblogic 8.1, Brio Intelligence 6.6; CA AllFusion ERwin 4.1; IBMI Rational Rose, RequisitePro; Visual Basic .NET, Sun Solaris 8,9; and Windows 2003 Servers. Commentary f rom a Documentum Developer based in Thousand Oaks, Cal i f . The team participated in a project to implement EDM R&D (980.13), a system that will provide new, greatly improved document management processes, services, and infrastructure specifically tailored for document management. The EDM R&D subsystem uses Documentum as the repository manager for and the FirstDoc application software for the creation and management of controlled documents. Various FirstDoc applications were implemented into the system including EDM Quality and EDM Engineering, Webtop, and FDRD. The environment for this project included Content Server 5.3/6.5, FirstDoc R&D 4.3/6.0, Documentum Application Builder 5.3, DFC, DQL, WDK 5.3/6.5, WebTop 5.3/6.5, Documentum Administrator 5.3/6.5, Solaris, Oracle 10g, WebLogic 9.2, and Tomcat 5. Commentary f rom an Informat ion Systems Associate based in Thousand Oaks, Cal i f . Amgen implemented “My Amgen” using Oracle BEA Plumtree 4.5 and 5.0 Web software. There is a team in place that provides technical and analytical support for portal communities, with the responsibility of guiding clients through the community development process from requirements gathering to rolling out into production. The team acts as a point of contact for all development communities, including Medical Sciences, APECS, CTD Submissions, Epidemiology, Global Biostats, Process & Capacity Management, ICOG, Development Contract Management, AmgenTrials, CTAG, AGS, Commercialization and CTA. Amgen performed a department-wide cleanup of the IS registry metadata for development. This project involved meeting with business and system owners of current applications and updating all relevant information. The company put in place a point of contact for all IS registry updates, additions, and questions for development. The inventory is critical after business hours, as this is the place where the Help Desk would go to find out escalation contacts in a distaste recovery event. The company installed AmgenTrials clinical trial posting using the Web content management system, Silkroad Eprise. This site is vital for posting clinical trials that Amgen offers for patients’ participation. Commentary f rom a Business Analyst based in Thousand Oaks, Cal i f . Part of the responsibilities of the ACT•1 business team is to facilitate secure, auditable and manageable collaboration between Amgen and its partners. Data is collected using Microsoft Access and Outlook and analyzed using NetScreen-Security Manager and HP Peregrine Systems, which is now HP OpenView. The team cross-referenced and updated the B2B Tracking Database from the original checklists in EDM Teams using Microsoft Access, Documentum and NetScreen-Security Manager. Team members supported documentation, project scheduling and time management for the Extranet Project, and designed and implemented administrative reports for the Partner Identity Automation (PIDA) project for account provisioning of the Extranet Project using Microsoft SQL and Cognos.

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Commentary f rom a Senior Systems Analyst based in Los Angeles, Ca l i f . In response to the highly competitive biotechnology/pharmaceutical industry, Amgen’s IS department has created a competitive intelligence application that monitors the firm’s internal and external environment for information, enhancing the decision-making process. The group designed the Competitive Intelligence (CI) Application using Microsoft Visual Basic (VB) 6 and Microsoft .NET Framework in an environment that included Windows XP, COM+, IIS, ActiveX, XML, XSLT, DHTML, JavaScript, T-SQL, Stored Procedures, Visual SourceSafe and SQL Server 2000. Commentary f rom a Cognos Consultant based in Thousand Oaks, Cal i f . Amgen developed and implemented a Cognos Data Warehousing application divided into Sales Reporting and Activity Reporting for use by each division responsible to do reporting to multiple business units. Each business unit has multiple sales teams. The reports are developed using various Cognos BI tools such as Impromptu, Power Play, IWR, and Upfront, then published and distributed to end-users. Access Manager Administrator was used to provide security for the Cognos BI applications. Commentary f rom a Project Coordinator in Process, Operat ions & Qual it y, Informat ion System Department, based in Thousand Oaks, Cal i f . As a major biotechnology research and development house for a wide number of cancer- and other disease-treating drugs, Amgen has created an IS team that coordinates on a multi-site Laboratory Implementation Management System (LIMS) program and Scientific Data Management System (SDMS) program. This group is responsible for identifying project work streams, as well as providing stakeholders with relevant roles and responsibilities. The group develops and project plan schedules for site specific sub-projects using PMIS (Project Management Information System) and 3PS, or Project Portfolio Performance System, with Microsoft Project 2002 with Web access. Through these solutions, the IS department can track and update project financial information against project budget and yearly budget. They also can maintain an updated status of work stream in any project plan and facilitate weekly status update reports of each project work stream. The system makes it easier to forecast project budget. The group gathers and analyzes financial data using Oracle JD Edwards to determine overall internal and external costs and latest estimate, while preventing discrepancies within the budget. The system tracks invoices coming in for contract resources and the hardware and software purchased for the project. The team is able to set up meeting agendas, and then facilitate meetings, take meeting minutes and action items, and post documents in a Livelink or Documentum database to ensure communication and completion of action items. This also works strategically in implementing a project change control management process, project issue escalation process, or project decision flow. Commentary f rom a Contract Manager based in Thousand Oaks, Cal i f . Amgen contracts out a large number of IT jobs and roles to consultants in a full-time capacity. Some of the responsibilities include RFI/RFP, ROI analysis, business case development, vendor selection as well as the implementation and project management responsibilities for Integrated Document Management (IDM) System in support of finance operations and strategic sourcing. This particular contract group managed the implementation and testing of several Electronic Data Interchange (EDI) relationships with key vendors to reduce invoice count and transaction processing

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costs. They also managed several Value Added Network providers including Advantis and GXS across multiple formats. They also ensure that all procurement practices are compliant with 2002 Sarbanes Oxley Act by developing new policies and procedures.

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BOARD OF DIRECTORS

Name Age Year Elected Boards and Other Af f i l iat ions

Keith W. Sharer 61 2000

Chairman of the Board; Former President of the Business Markets Division of MCI Communications Corporation; Formerly served in numerous executive capacities at General Electric Company; Director, Chevron Corporation and Northrop Grumman Corporation

David Baltimore 71 1999

President Emeritus and Professor of Biology, California Institute of Technology; Former President of Caltech; Previously an Institute Professor at the Massachusetts Institute of Technology; Director of BB Biotech, AG, a Swiss investment company; Co-recipient of the Nobel Prize in Medicine

Frank J. Biondi, Jr. 64 2002

Senior Managing Director of WaterView Advisors LLC; Formerly served as Chairman and Chief Executive Officer of Universal Studios, Inc.; Past President and CEO, Viacom, Inc.; Director, Cablevision Systems Corp., Hasbro, Inc., Seagate Technology and Yahoo! Inc.; Former Member of the board of directors of The Bank of New York Mellon Corporation

François de Carbonnel 63 2008

Non-executive Chairman of the Board and director of Thomson S.A.; On the Boards of Pages Jaunes S.A. and of Quilvest S.A.; Ecofin Global Utilities Hedge Fund Ltd. and Ecofin North America Utilities Hedge Fund Ltd.; Served as Senior Advisor of the Global Corporate and Investment Bank of Citigroup; Past Managing Director and member of the Operating Committee, Global Corporate and Investment Bank of Citigroup; Served as Chairman and CEO, Midial S.A.; Formerly served as Chairman of General Electric Capital SNC; Past President, GE Capital-Europe, EVP of GE Capital and VP of GE; Former VP, Boston Consulting Group; French citizen and resides in Europe

Jerry D. Choate 70 1998

Former Chairman of the Board and CEO, The Allstate Corporation; Director, Valero Energy Corporation and serves on the Board of Trustees for the Van Kampen Mutual Funds

Vance D. Coffman 64 2007

Former Chairman of the Board and other executive positions at Amgen, Member of the National Academy of Engineering; Fellow in the American Institute of Aeronautics and Astronautics and the American Astronautical Society; Director, 3M Company and Deere & Company

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Frederick W. Gluck 73 1998

Non-executive Chairman of the Board of CytomX Therapeutics, LLC and Cynvenio Biosystems LLC; Former managing partner, McKinsey & Company, Inc.; Former Vice Chairman and Director, Bechtel Group

Frank C. Herringer 66 2004

Formerly Chairman of the Board and CEO, Transamerica Corporation; Former Executive Board Director, Aegon N.V.; Past Chairman of the Board, Aegon U.S.A.; Director of The Charles Schwab Corporation and Safeway Inc.

Gilbert S. Omenn 67 1987

Professor of Internal Medicine, Human Genetics and Public Health at the University of Michigan; Former Dean of the School of Public Health and Community Medicine and Professor of Medicine at the University of Washington; Director, Rohm & Haas Co. and Armune BioScience, Inc.

Judith C. Pelham 63 1995

President Emeritus of Trinity Health; Sits on the board of trustees of Smith College; Former President and CEO, Trinity Health; Past President and CEO, Daughters of Charity Health Services, Austin, Texas

Adm. J. Paul Reason, USN (Retired) 68 2001

Formerly served as Vice Chairman and Director, Metro Machine Corporation; Past President and COO, Metro Machine; Former U.S. Navy Four Star Admiral and Commander-In-Chief of the U.S. Atlantic Fleet; Served in numerous capacities, both at sea and ashore, in the U.S. Navy; Director of Norfolk Southern Corporation and Todd Shipyards Corporation

Leonard D. Schaeffer 63 2004

Chairman of the Board of Surgical Care Affiliates, LLC and a Senior Advisor for Texas Pacific Group; Former Chairman of the Board of Directors, WellPoint Inc.; Formerly served as Chairman and CEO, WellPoint Health Networks Inc.; Former Administrator of the U.S. Health Care Financing Administration (now CMS); Member of the Institute of Medicine; Director of Allergan, Inc. and Quintiles Transnational Corp.

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Fi rst Last Tit le Phone E-Mail

Gale Alcorn Manager, Web & Collaboration 805-447-1000 [email protected]

Lee Allen Director, Web & Collaboration Services 805-447-1000 [email protected]

Omer Arman Web Portal System Analyst 805-447-1000 [email protected]

Todd Barnum Director, Information Security 805-447-1000 [email protected]

Gina Beck Sr. Manager, Enterprise Systems 805-447-1000 [email protected]

Charlie Bonar Senior Manager, Information Systems 805-447-1000 [email protected]

Keith Brown VP, Enterprise Systems 805-447-1000 [email protected]

David Christie Director, Information Systems 805-447-1915 [email protected]

Peter Flack Director, Information Systems Infrastructure 805-447-1000 [email protected]

Thomas Flanagan SVP and CIO 805-447-1000 [email protected]

Michael Gabriel Manager, Application Development 805-447-1000 [email protected]

Andy Gore Director, Web Communications 805-447-1000 [email protected]

Vicki Gottmer Chief Information Officer-Assistant 805-447-1000 [email protected]

Danny Hanie Manager Network/Telecom 805-447-1000 [email protected]

David Hansen Director, Information Systems 805-447-1000 [email protected]

Jon Hartman Director of Information Systems Management 805-447-1000 [email protected]

Reese Hepburn IT Audit Manager 805-447-1000 [email protected]

Phil Hoeh Director, Information Technology 805-447-1000 [email protected]

Wendy Holder

Sr. Manager, IS Service Management & Governance 805-447-1000 [email protected]

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Duane Howard Senior Associate IS Security Engineer 805-447-1000 [email protected]

Sandra Hueb Hueb Sr. Manager, Information Technology 805-447-1000 [email protected]

Jamie Kiguchi Director, Information Systems 805-447-1000 [email protected]

Vasudev Killada Teradata DBA and Architect 805-447-1000 [email protected]

Nancy Lehrer

Director of Information Systems, Solutions Architecture 805-447-1000 [email protected]

Darryl Levi Website Administrator 805-447-1000 [email protected]

Carmen Maronde Director, Information Systems 805-447-1000 [email protected]

Brian McBreen Jr. Sr. Manager, Web & Collaboration Services 805-447-1000 [email protected]

Diana McKenzie VP, Information Systems 805-447-1000 [email protected]

Jan Meier Executive Director, Information Systems 805-447-1000 [email protected]

Jim Niehoff

Director of Global Business Intelligence and Master Data Management 805-447-1000 [email protected]

Vadim Parizher Director, Information Systems 805-447-1000 [email protected]

Terri Parks Director, Information Systems 805-447-1000 [email protected]

Thornton Prime Director, Information Security and Compliance 805-447-1000 [email protected]

Rick Renshaw

Sr. Manager, IS Disaster Recovery, Risk Management 805-447-1000 [email protected]

Todd Rowe IS Business Systems Analyst 805-447-1000 [email protected]

Sandra Sequeira Manager, Information Systems 805-447-1000 [email protected]

Joan Skelly Manager, IS Data Center Operations 805-447-1000 [email protected]

Fred Sookiasian

Manager, IT Services (Siebel/Quality Assurance Testing Services) 805-447-1000 [email protected]

Joe Soriano Manager, Information Systems 805-447-7825 [email protected]

Jim Stites IS Manager Network/Telecom 805-447-1000 [email protected]

Bonnie Taylor Sr. Security Manager 805-447-1000 [email protected]

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Darlene Thomas-Woods

Director Information Systems 805-447-6866 [email protected]

Carmen Torres Sr. Manager, Information Systems 805-447-1000 [email protected]

Jason Viera Network Architect 805-447-1000 [email protected]

James Whiteley Principal Infrastructure Architect 805-447-1000 [email protected]

radboud Wijnen CIO, International/Netherlands 805-447-1000 [email protected]

Chad Willard Sr. Manager IS, Network Services 805-447-1000 [email protected]

Mike Zahigian Director, Information Systems 805-447-1000 [email protected]

Denis Zerr Executive Director, Operations IS 805-447-1000 [email protected]

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Fi rst Last Tit le Phone E-Mail

Nahed Ahmed

VP, Project Management Research and Development 805-447-1000 [email protected]

Ted Bagley VP, Human Resources 805-447-1000 [email protected]

Madhavan Balachandran SVP, Manufacturing 805-447-1000 [email protected]

David W. Beier SVP, Global Government and Corporate Affairs 805-447-1000 [email protected]

Fabrizio Bonanni EVP, Operations 805-447-1000 [email protected]

Robert Bradway EVP and CFO 805-447-1000 [email protected]

David Chang VP, Global Oncology Development 805-447-1000 [email protected]

Jacqueline S. Crouse VP, Taxes 805-447-1000 [email protected]

Rodger Currie VP, Government Affairs 805-447-1000 [email protected]

James M. Daly SVP, North America Commercial Operations 805-447-1000 [email protected]

Kelley Davenport

Media Contact Government Policy/Reimbursement 805-447-1000 [email protected]

Kristen Davis Senior Manager Corporate Communications 805-447-1000 [email protected]

Willard H. Dere SVP and International Chief Medical Officer 805-447-1000 [email protected]

Paul R. Eisenberg SVP, Global Regulatory Affairs and Safety 805-447-1000 [email protected]

Jeanne Fitzgerald Senior Director, Marketing Operations 805-447-1000 [email protected]

Scott J. Foraker VP, Licensing 805-447-1000 [email protected]

Paul Greenland Business Unit Director 805-447-1000 [email protected]

Sean E. Harper

VP, Global Regulatory Affairs and Corporate Chief Medical Officer 805-447-1000 [email protected]

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Rolf K. Hoffmann SVP, International Commercial Operations 805-447-1000 [email protected]

Durk Hubel Senior Analyst, Investor Relations 805-447-1000 [email protected]

Ken Keller

VP and General Manager, Inflammation Business Unit 805-447-1000 [email protected]

Michael A. Kelly VP, Finance and Chief Accounting Officer 805-447-1000 [email protected]

Mary Klem Director, Corporate Communications 805-447-1000 [email protected]

David L. Lacey SVP, Research 805-447-1000 [email protected]

Jonathan Landon Associate Director, Marketing 805-447-1000 [email protected]

Susanne Laningham Director, Business Analysis and Information 805-447-1000 [email protected]

Jean J. Lim President, Amgen Foundation 805-447-1000 [email protected]

Brian M. McNamee SVP, Human Resources 805-447-1000 [email protected]

Farryn Melton VP and Chief Procurement Officer 805-447-1000 [email protected]

Joseph P. Miletich SVP, Research and Development 805-447-1000 [email protected]

Cara Miller Director, Corporate Compliance 805-447-1000 [email protected]

Alison Moore Vice President Site Operations 805-447-1000 [email protected]

George J. Morrow EVP, Global Commercial Operations 805-447-1000 [email protected]

Connie Murphree Senior Manager Supplier Relationship 805-447-1000 [email protected]

Philip Noguchi Director, Regulatory Affairs 805-447-1000 [email protected]

Joshua Ofman VP, Reimbursement and Payment Policy 805-447-1000 [email protected]

Susan O’Neal Director, Human Resources 805-447-1000 [email protected]

Roger M. Perlmutter EVP, Research and Development 805-447-1000 [email protected]

Phyllis J. Piano

VP, Corporate Communications and Philanthropy 805-447-1000 [email protected]

David Polk

Executive Director, Corporate Communications 805-447-1000 [email protected]

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30

Sari H. Ratican

Chief Privacy Officer, Worldwide Compliance & Business Ethics 805-447-1000 [email protected]

Christine Regan Media Contact 805-447-1000 [email protected]

Anna S. Richo SVP and Chief Compliance Officer 805-447-1000 [email protected]

Jill Rogers Executive Director 805-447-1000 [email protected]

Steven J. Schoch VP, Finance 805-447-1000 [email protected]

David J. Scott SVP, General Counsel and Secretary 805-447-1000 [email protected]

Kevin W. Sharer Chairman, President and CEO 805-447-1000 [email protected]

Geoffrey F. Slaff VP, Quality 805-447-1000 [email protected]

Arvind K. Sood VP, Investor Relations 805-447-1000 [email protected]

Helen Torley VP and General Manager, Nephrology 805-447-1000 [email protected]

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CRUSH Report™ is a trademark and the property of SELIGENCE, LLC. The information contained in CRUSH Report was compiled by SELIGENCE, LLC from public sources (“the information”). The information has not been verified by SELIGENCE, LLC. It is understood that SELIGENCE, LLC is not responsible for the accuracy of the information. The sale of CRUSH Report by parties other than SELIGENCE, LLC is prohibited. SELIGENCE, LLC clients may not forward or distribute CRUSH Report to third parties.

Amgen - CRUSH Report - 09B2

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