-
Amfm Independent Evaluation Team: Hanson, K; Goodman, C;
Tougher,S; Mann, A; Willey, B; Arnold, F; Ye, Y; Ren, R; Yoder, S
(2012)Independent Evaluation of Phase 1 of the Affordable Medicines
Facil-ity - malaria (AMFm), Multi-Country Independent Evaluation
FinalReport. Technical Report. ICF International and London School
ofHygiene and Tropical Medicine, Calverton, Maryland and
London.
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Multi-Country Independent Evaluation Report
Independent Evaluation of the
Affordable Medicines Facility - malaria (AMFm) Phase 1
Final Report
September 28, 2012
-
1
Independent Evaluation of Phase 1 of the Affordable
Medicines
Facility - malaria (AMFm)
Multi-Country Independent Evaluation Report:
Final Report
September 28, 2012
AMFm Independent Evaluation Team
ICF International:
London School of Hygiene and
Tropical Medicine:
Fred Arnold
Yazoume Ye
Ruilin Ren
Stan Yoder
Kara Hanson
Catherine Goodman
Sarah Tougher
Andrea Mann
Barbara Willey
Submitted to:
The Global Fund to Fight AIDS, Tuberculosis and Malaria
Submitted by:
ICF International
11785 Beltsville Drive, Suite 300, Calverton, MD 20705, USA
and
The London School of Hygiene and Tropical Medicine
Recommend citation:
AMFm Independent Evaluation Team (2012). Independent Evaluation
of Phase 1 of the
Affordable Medicines Facility - malaria (AMFm), Multi-Country
Independent Evaluation Report:
Final Report. Calverton, Maryland and London: ICF International
and London School of Hygiene
and Tropical Medicine.
This version of the report includes the following information
not previously included in the Preliminary
Report of July 18, 2012: (i) results from the remote areas
study; (ii) results from the logo study (exit
interviews and focus group discussions); (iii) an annex
describing the Consultative Forum held in June
2012 in Nairobi; and (iv) some new content to Section 1.2
Overview of the AMFm, including orders
requested, approved and delivered as of end September 2012. None
of this new information has affected the
assessment of the achievements of the Phase 1 benchmarks that
were included in the preliminary report of
July 18, 2012.
This version of the report does not include findings from the
endline household surveys. Those findings will
be included in a supplemental report when endline data become
available.
-
i
Data Contributors (Institutions in alphabetical order):
Data Contributors for Outlet Surveys
African Population and Health Research Centre, Kenya
Marilyn Wamukoya
Yohannes Kinfu
Blessing Mberu
Centre de Recherche pour le Dveloppement Humain (CRDH) /
International d'Etudes et de
Recherches sur les Populations Africaines (CIERPA), Niger
Salif Ndiaye
Idrissa Alichina Kourgueni
Moctar Seydou
Oumarou Malam
Drugs for Neglected Diseases initiative (DNDi)/Research and
Development Unit, Komfo Anokye
Teaching Hospital (KATH), Ghana
Graciela Diap
John Amuasi
Samuel Blay Nguah
Ohene Buabeng
Ifakara Health Institute (IHI) - IMPACT 2 Project, Tanzania
Rebecca Thomson
Johanes Boniface
Admirabilis Kalolella
Charles Festo
Mark Taylor
Katia Bruxvoort
Population Service International (PSI) - ACTwatch Project,
Kenya, Madagascar, Nigeria, Uganda,
Zanzibar
Tanya Shewchuk
Kate OConnell
Hellen Gatakaa
Stephen Poyer
Julius Njogu
Mitsuru Toda
Illah Evance
James Kajuna
Baraka Kaaya
Jacky Raharinijatovo
Ekundayo Arogundade
Peter Buyungo
Edna Adhiambo Ogada
-
ii
Data Contributors for Remote Area Surveys
African Population and Health Reseach Centre (APHRC)
Catherine Kyobutungi
Blessing Nberu
Marylin Wamukoya
Fredrick Wekesa
Komfo Anokye Teaching Hospital (KATH)
John Amuasi
Samual Blay
Daniel Ansong
Independent consultant Defining the remote areas
Abdisalan Noor
Data Contributors for Logo Study (Exit Interviews and Focus
Group Discussions)
Ghana: TNS RMS Ghana
Adewake Obaseki
Agyakwa Ayisi Addo
Marilyn Oduro-Ntiamoah
Kenya: African Institute for Health and Development (AIHD)
Mary Amuyunzu-Nyamongo
Monica Wabuke
Madagascar: Institut National des Statistiques de Madagascar
(INSTAT)
Victor Rabeza Rafaralahy
Heretiana Randriandrasana
Nigeria: TNS RMS Nigeria Limited
Mariam Fagbemi
Olugbenga Afolabi Ogunmefun
Data Contributors for Country Case Studies
Ghana Elizabeth Juma
Kenya Abdinasir Amin
Madagascar Sergio Torres Rueda
Niger Diadier Diallo
Nigeria Catherine Adegoke
Tanzania mainland Catherine Goodman
Uganda Sarah Tougher
Zanzibar Yazoume Ye
-
iii
Table of contents
TABLE OF CONTENTS
..................................................................................................................................
III
LIST OF TABLES
............................................................................................................................................
VII
LIST OF FIGURES
..........................................................................................................................................
XII
LIST OF ABBREVIATIONS
.........................................................................................................................
XIV
DEFINITION OF KEY TERMS
.................................................................................................................
XVIII
OVERVIEW OF THE INDEPENDENT EVALUATION OF AMFM
....................................................... XIX
EXECUTIVE SUMMARY
..........................................................................................................................
XXIV
1 BACKGROUND AND METHODS
..........................................................................................................
1
1.1 EVALUATION BACKGROUND
.....................................................................................................................
1 1.2 OVERVIEW OF AMFM
...............................................................................................................................
2
1.2.1 Origins of the AMFm
......................................................................................................................
2 1.2.2 Technical Design of the AMFm
......................................................................................................
3 1.2.3 Global Funds Hosting and Management of the AMFm
................................................................. 3
1.2.4 Funding sources
..............................................................................................................................
5 1.2.5 Negotiations with eligible manufacturers
.......................................................................................
5 1.2.6 AMFm copayments processed and volume of copaid ACTs
delivered ............................................ 7 1.2.7
Typical ordering behavior: Differences between public and private
sector buyers ..................... 12 1.2.8 Implementation and
country-level effects of demand-shaping levers
........................................... 14 1.2.9 Evolution of
adult versus child pack orders over time
..................................................................
15 1.2.10 Disbursement delays for supporting interventions
...................................................................
17 1.2.11 Overview of timing of AMFm implementation
.........................................................................
17 1.2.12 Summary of AMFm implementation
.........................................................................................
20
1.3 OVERVIEW OF AMFM PHASE 1 COUNTRIES
............................................................................................
22 1.3.1 Ghana
...........................................................................................................................................
22 1.3.2 Kenya
............................................................................................................................................
23 1.3.3 Madagascar
..................................................................................................................................
24 1.3.4 Niger
.............................................................................................................................................
25 1.3.5 Nigeria
..........................................................................................................................................
27 1.3.6 Tanzania mainland
....................................................................................................................
28 1.3.7 Uganda
.........................................................................................................................................
29 1.3.8 Zanzibar
........................................................................................................................................
30
1.4 EVALUATION FRAMEWORK
.....................................................................................................................
32 1.4.1 Impact model
................................................................................................................................
33 1.4.2 Evaluation design
.........................................................................................................................
36 1.4.3 Additional studies
.........................................................................................................................
37
1.5 KEY EVALUATION QUESTIONS AND INDICATORS
.....................................................................................
38 1.6 EVALUATION APPROACH
.........................................................................................................................
41
1.6.1 Overview of methods and tools
.....................................................................................................
41 1.6.2 Outlet surveys
...............................................................................................................................
42 1.6.3 Household survey data - Secondary
analysis................................................................................
51 1.6.4 Implementation process and contextual information
....................................................................
53 1.6.5 Remote area study
.........................................................................................................................
55 1.6.6 Public awareness - AMFm logo study
..........................................................................................
60 1.6.7 Interpretation and operationalization of success metrics
............................................................. 63
1.6.8 Ethical approval
...........................................................................................................................
67 1.6.9 Discussion of strengths and limitations of the Independent
Evaluation ....................................... 67
1.7 CONSULTATIVE FORUM
..........................................................................................................................
73
2 RESULTS FROM OUTLET SURVEYS
................................................................................................
74
2.1 DESCRIPTION OF SAMPLE AND CHARACTERISTICS OF OUTLETS
............................................................... 74
2.1.1 Description of sample at baseline and at endline
.........................................................................
74 2.1.2 Characteristics of the outlets
........................................................................................................
82
2.2 EVALUATION QUESTION ON ACT AVAILABILITY
....................................................................................
94 2.2.1 Antimalarials in stock
...................................................................................................................
94
-
iv
2.2.2 Antimalarials in stock by type
.......................................................................................................
97 2.2.1 Stockouts of quality-assured ACTs
.............................................................................................
112 2.2.2 Population coverage of outlets with quality-assured ACTs
........................................................ 115
2.3 EVALUATION QUESTION ON ACT AFFORDABILITY
................................................................................
118 2.3.1 Cost to patients of antimalarials
.................................................................................................
118 2.3.2 Gross markup between purchase price and retail selling
price .................................................. 141 2.3.3
Total gross markup from first line buyer purchase price to retail
selling price ......................... 152 2.3.4 Availability and
cost to patients of diagnostic tests (RDT/microscopy)
..................................... 155
2.4 MARKET SHARE OF QUALITY-ASSURED ACTS
......................................................................................
170 2.5 PROVIDER KNOWLEDGE OF FIRST LINE ANTIMALARIAL TREATMENT AND
QUALITY-ASSURED ACT DOSING REGIMEN
............................................................................................................................................
182
2.5.1 Provider Knowledge of first line antimalarial treatment
............................................................ 182
2.5.2 Provider knowledge of quality-assured ACT dosing regimen for
an adult and a child .............. 185 2.5.3 Reasons for not
stocking quality-assured
ACTs..........................................................................
190
2.6 AMFM LOGO, RECOMMENDED RETAIL PRICE AND PROVIDER TRAINING
................................................ 193
3 RESULTS FROM HOUSEHOLD SURVEYS
.....................................................................................
211
3.1 FEVER PREVALENCE
..............................................................................................................................
211 3.2 ANTIMALARIAL TREATMENT AMONG CHILDREN WITH FEVER
............................................................... 213
3.3 DIAGNOSTIC TESTING
............................................................................................................................
220 3.4 ANTIMALARIAL TREATMENT AMONG CHILDREN WITH FEVER FROM THE
POOREST HOUSEHOLDS.......... 222
4 IMPLEMENTATION PROCESS AND CONTEXT - FINDINGS FROM THE COUNTRY
CASE STUDIES
...........................................................................................................................................................
224
4.1 GHANA
..................................................................................................................................................
224 4.1.1 AMFm implementation process
..................................................................................................
224 4.1.2 Implementation of AMFm supporting interventions
...................................................................
226 4.1.3 Implementation of non-AMFm interventions
..............................................................................
227 4.1.4 Key events and context
................................................................................................................
228 4.1.5 Conclusion
..................................................................................................................................
228
4.2 KENYA
..................................................................................................................................................
231 4.2.1 AMFm implementation process
..................................................................................................
231 4.2.2 Implementation of AMFm supporting interventions
...................................................................
234 4.2.3 Implementation of non-AMFm interventions
..............................................................................
238 4.2.4 Key events and context
................................................................................................................
239 4.2.5 Conclusion
..................................................................................................................................
239
4.3 MADAGASCAR
......................................................................................................................................
242 4.3.1 Description of the AMFm implementation process
.....................................................................
242 4.3.2 Implementation of AMFm supporting interventions
...................................................................
243 4.3.3 Key events and context
................................................................................................................
247 4.3.4 Conclusion
..................................................................................................................................
247
4.4 NIGER
...................................................................................................................................................
250 4.4.1 AMFm implementation process
..................................................................................................
250 4.4.2 Implementation of AMFm supporting interventions
...................................................................
253 4.4.3 Key events and context
................................................................................................................
257 4.4.4 Conclusion
..................................................................................................................................
257
4.5 NIGERIA
................................................................................................................................................
260 4.5.1 AMFm intervention process
........................................................................................................
260 4.5.2 Implementation of AMFm supporting intervention
.....................................................................
262 4.5.3 Key events and context
................................................................................................................
265 4.5.4 Conclusion
..................................................................................................................................
266
4.6 TANZANIA - MAINLAND
........................................................................................................................
270 4.6.1 AMFm implementation process
..................................................................................................
270 4.6.2 Implementation of AMFm supporting interventions
...................................................................
272 4.6.3 Key event and context
.................................................................................................................
277 4.6.4 Conclusion
..................................................................................................................................
277
4.7 UGANDA
...............................................................................................................................................
280 4.7.1 AMFm implementation process
..................................................................................................
280 4.7.2 Implementation of AMFm Supporting Interventions
...................................................................
285 4.7.3 Key events and context
................................................................................................................
289
-
v
4.7.4 Conclusion
..................................................................................................................................
290 4.8 ZANZIBAR
.............................................................................................................................................
292
4.8.1 AMFm implementation process
..................................................................................................
292 4.8.2 Implementation of AMFm supporting interventions
...................................................................
295 4.8.3 Key events and context
................................................................................................................
299 4.8.4 Conclusion
..................................................................................................................................
299
5 RESULTS FROM THE REMOTE AREA
STUDY.............................................................................
302
5.1 DESCRIPTION OF THE SAMPLE
...............................................................................................................
302 5.2 AVAILABILITY OF QUALITY-ASSURED ACTS IN REMOTE AREAS
........................................................... 305
5.2.1 Stockouts of quality-assured ACTs in remote areas
...................................................................
308 5.2.2 Population coverage of outlets with quality-assured ACTs
in remote areas .............................. 308
5.3 PRICING OF QUALITY-ASSURED ACTS IN REMOTE AREAS
.....................................................................
310 5.4 GROSS MARKUP BETWEEN PURCHASE PRICE AND RETAIL SELLING
PRICE OF QUALITY-ASSURED ACTS IN REMOTE AREAS
...............................................................................................................................................
314 5.5 AVAILABILITY AND COST TO PATIENTS OF MALARIA DIAGNOSTIC
TESTS IN REMOTE AREAS ................. 316 5.6 MARKET SHARE FOR
QUALITY-ASSURED ACTS IN REMOTE AREAS
....................................................... 319 5.7
AMFM LOGO IN REMOTE AREAS
...........................................................................................................
321 5.8 SUMMARY OF RESULTS
.........................................................................................................................
323
6 RESULTS FROM THE LOGO STUDY (EXIT INTERVIEWS AND FOCUS GROUP
DISCUSSIONS)
................................................................................................................................................
324
6.1 EXIT INTERVIEWS
..................................................................................................................................
324 6.1.1 Description of the sample
...........................................................................................................
324 6.1.2 Reasons for choosing a malaria treatment
.................................................................................
325 6.1.3 Source of information about ACTs
.............................................................................................
326 6.1.4 Knowledge of AMFm logo
..........................................................................................................
327 6.1.5 Meaning of the AMFm logo
........................................................................................................
330 6.1.6 Summary of results from exit interviews
.....................................................................................
331
6.2 FOCUS GROUP DISCUSSIONS
..................................................................................................................
332 6.2.1 Description of the sample
...........................................................................................................
332 6.2.2 Knowledge of treatment of malaria
............................................................................................
332 6.2.3 Knowledge and perceived availability of ACTs
..........................................................................
333 6.2.4 Knowledge and perception of the AMFm logo
...........................................................................
334 6.2.5 Summary of the results of the focus group discussions
...............................................................
335
7 SUMMARY OF KEY FINDINGS FROM RELEVANT OPERATIONAL RESEARCH
............... 337
8 SUCCESS METRICS AND INTERPRETATION
..............................................................................
343
8.1 GHANA
..................................................................................................................................................
343 8.1.1 Achievement of AMFm objectives
...............................................................................................
343 8.1.2 Supply of AMFm copaid drugs
...................................................................................................
346 8.1.3 Implementation of supporting interventions
...............................................................................
347 8.1.4 Context
........................................................................................................................................
348 8.1.5 Summary
.....................................................................................................................................
348
8.2 KENYA
..................................................................................................................................................
350 8.2.1 Achievement of AMFm objectives
...............................................................................................
350 8.2.2 Supply of AMFm copaid drugs
...................................................................................................
353 8.2.3 Implementation of supporting interventions
...............................................................................
354 8.2.4 Context
........................................................................................................................................
355 8.2.5 Summary
.....................................................................................................................................
355
8.3 MADAGASCAR
......................................................................................................................................
356 8.3.1 Achievement of the objectives
.....................................................................................................
356 8.3.2 Supply of AMFm copaid drugs
...................................................................................................
360 8.3.3 Implementation of supporting interventions
...............................................................................
360 8.3.4 Context
........................................................................................................................................
361 8.3.5 Summary
.....................................................................................................................................
362
8.4 NIGER
...................................................................................................................................................
363 8.4.1 Achievement of the objectives
.....................................................................................................
363 8.4.2 Supply of AMFm copaid drugs
...................................................................................................
365 8.4.3 Implementation of supporting interventions
...............................................................................
366
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vi
8.4.4 Context
........................................................................................................................................
367 8.4.5 Summary
.....................................................................................................................................
367
8.5 NIGERIA
................................................................................................................................................
368 8.5.1 Achievement of the objectives
.....................................................................................................
368 8.5.2 Supply of AMFm copaid drugs
...................................................................................................
370 8.5.3 Implementation of supporting interventions
...............................................................................
371 8.5.4 Context
........................................................................................................................................
373 8.5.5 Summary
.....................................................................................................................................
373
8.6 TANZANIA MAINLAND
...........................................................................................................................
374 8.6.1 Achievement of AMFm objectives
...............................................................................................
374 8.6.2 Supply of AMFm copaid drugs
...................................................................................................
376 8.6.3 Implementation of supporting interventions
...............................................................................
377 8.6.4 Context
........................................................................................................................................
378 8.6.5 Summary
.....................................................................................................................................
379
8.7 UGANDA
...............................................................................................................................................
380 8.7.1 Achievement of AMFm objectives
...............................................................................................
380 8.7.2 Supply of AMFm copaid drugs
...................................................................................................
383 8.7.3 Implementation of supporting interventions
...............................................................................
384 8.7.4 Context
........................................................................................................................................
385 8.7.5 Summary
.....................................................................................................................................
385
8.8 ZANZIBAR
.............................................................................................................................................
386 8.8.1 Achievement of AMFm objectives
...............................................................................................
386 8.8.2 Supply of AMFm copaid drugs
...................................................................................................
389 8.8.3 Implementation of supporting interventions
...............................................................................
389 8.8.4 Context
........................................................................................................................................
390 8.8.5 Summary
.....................................................................................................................................
391
9
CONCLUSION........................................................................................................................................
392
9.1 CONCLUSION
.........................................................................................................................................
392
10 REFERENCES
........................................................................................................................................
396
11 ACKNOWLEDGEMENTS
....................................................................................................................
403
12 APPENDICES
.........................................................................................................................................
404
-
vii
List of tables Table 1: Quantity of copaid quality-assured ACTs
delivered, July 2010 December 2011 ...........................
xxviii
Table 2: Quantity of copaid quality-assured ACTs delivered,
January 2012 September 2012 .................... xxviii
Table 1.2.1: Quantity of copaid quality-assured ACTs requested,
approved, and delivered, July 2010
December 2011
.............................................................................................................................................
8
Table 1.2.2: Quantity of copaid quality-assured ACTs requested,
approved, and delivered, January 2012
September
2012...........................................................................................................................................
10
Table 1.2.3: Differences between public and private sector
buyers
.....................................................................
12
Table 1.2.4: Number of first-line buyers which received
deliveries* of quality-assured ACT treatments through
AMFm
.........................................................................................................................................................
13
Table 1.2.5: Quality-assured ACT treatments requested by private
not-for-profit and private for-profit first-line
buyers and approved by the Global Fund, 3rd
quarter and 4th
quarter of 2011 ............................................
15
Table 1.2.6: Quality-assured ACT treatments requested by private
not-for-profit and private for-profit first-line
buyers and approved by the Global Fund, 1st quarter, 2
nd quarter and 3
rd quarter of 2012 .......................... 15
Table 1.2.7: Summary of AMFm implementation
................................................................................................
21
Table 1.5.1: List of key indicators for the independent
evaluation
.......................................................................
40
Table 1.6.1: Link between outlet and household surveys and the
evaluation questions ....................................... 41
Table 1.6.2: Timing of data collection for outlet surveys and
arrival of copaid ACTs by country ...................... 43
Table 1.6.3: Number of clusters by domain for each country
...............................................................................
44
Table 1.6.4: Local currencies and their USD equivalents using
the average interbank rate, 2010 ....................... 50
Table 1.6.5: Summary of existing household surveys that include
information on ACT use ............................... 52
Table 1.6.6: Timing of data collection for baseline and endline
household surveys in relation to arrival of the
first copaid ACTs by country
......................................................................................................................
53
Table 1.6.7: Number and dates of key informant interviews
conducted
...............................................................
54
Table 1.6.8: Remote area clusters selected for the AMFm
Independent Evaluation remote area survey ............. 58
Table 1.6.9: E2Pi metrics and benchmarks for success and their
operationalization by the IE ............................ 64
Table 2.1.1: Survey sample breakdown: Number of outlets
enumerated and number stocking antimalarials by
urban-rural location, according to country at baseline (2010)
and endline (2011) ...................................... 75
Table 2.1.2: Number of outlets by final interview status and
urban-rural location, according to country at
baseline (2010) and endline (2011)
.............................................................................................................
76
Table 2.1.3: Number of outlets enumerated by type of outlet and
urban-rural location, according to country at
baseline (2010) and endline (2011)
.............................................................................................................
78
Table 2.1.4: Number of outlets with antimalarials in stock by
type of outlet and urban-rural location, according
to country at baseline (2010) and endline (2011)
........................................................................................
80
Table 2.2.1: Outlets with antimalarials in stock at baseline
(2010) and endline (2011) .......................................
95
Table 2.2.2: Outlets with non-artemisinin therapy in stock at
baseline (2010) and endline (2011)...................... 99
Table 2.2.3: Outlets with artemisinin monotherapy in stock at
baseline (2010) and endline (2011) .................. 101
Table 2.2.4: Outlets with oral artemisinin monotherapy in stock
at baseline (2010) and endline (2011) ........... 103
Table 2.2.5: Outlets with non-quality-assured ACTs in stock at
baseline (2010) and endline (2011)................ 105
Table 2.2.6: Outlets with quality-assured ACTs in stock at
baseline (2010) and endline (2011) ....................... 107
Table 2.2.7: Outlets with quality-assured ACTs with and without
the AMFm logo in stock at endline, 2011 .. 109
Table 2.2.8: Public health facilities with quality-assured ACTs
in stock among ALL public health facilities at
baseline (2010) and endline (2011)
...........................................................................................................
111
Table 2.2.9: Outlets with stock-outs of quality-assured ACTs at
baseline (2010) and endline (2011) ............... 113
Table 2.2.10: Percentage of the population living in
subdistricts with outlets with quality-assured ACTs in
stock at baseline (2010) and endline (2011)
..............................................................................................
116
Table 2.3.1: Cost to patients of non-artemisinin therapy, in
2010 US dollars, at baseline (2010) and
endline(2011)
............................................................................................................................................
121
Table 2.3.2: Cost to patients of artemisinin monotherapy, in
2010 US dollars, at baseline (2010) and endline
(2011)
........................................................................................................................................................
123
-
viii
Table 2.3.3: Cost to patients of oral artemisinin monotherapy,
in 2010 US dollars, at endline, 2011 ................ 125
Table 2.3.4: Cost to patients of non-quality-assured ACTs, in
2010 US dollars, at baseline (2010) and endline
(2011)
........................................................................................................................................................
127
Table 2.3.5: Cost to patients of quality-assured ACTs (including
formulations for adults and children), in 2010
US dollars, at baseline (2010) and endline (2011)
....................................................................................
129
Table 2.3.6: Cost to patients of quality-assured ACTs (including
formulations for adults and children) by
presence of the AMFm logo, in 2010 US dollars, at endline, 2011
.......................................................... 131
Table 2.3.7: Cost to patients of quality-assured ACTs (pediatric
formulations only), in 2010 US dollars, at
baseline (2010) and endline (2011)
...........................................................................................................
133
Table 2.3.8: Cost to patients of quality-assured ACTs (pediatric
formulations only) by presence of the AMFm
logo, in 2010 US dollars, at endline, 2011
................................................................................................
135
Table 2.3.9: Cost to patients in private for-profit outlets, of
the most popular antimalarial which is not a QAACT
in terms of private for-profit outlet sales volumes for TABLETS
and ALL DOSAGE FORMS in 2010 US
dollars at endline 2011
..............................................................................................................................
138
Table 2.3.10: Ratio of the cost to patients of quality-assured
ACTs with the AMFm logo to the cost to patients
of the most popular antimalarial which is not a QAACT for
TABLETS in private for-profit outlets in 2010
US dollars, at endline, 2011
......................................................................................................................
138
Table 2.3.11: Ratio of the cost to patients of quality-assured
ACTs with the AMFm logo to the cost to patients
of the most popular antimalarial which is not a QAACT for ALL
DOSAGE FORMS in private for-profit
outlets in 2010 US dollars, at endline,
2011..............................................................................................
139
Table 2.3.12: Ratio of the cost to patients of quality-assured
ACTs with the AMFm logo to the cost to patients
of artemisinin monotherapy TABLETS in private for-profit outlets
in 2010 US dollars, at endline, 2011
..................................................................................................................................................................
139
Table 2.3.13: Ratio of the cost to patients of quality-assured
ACTs with the AMFm logo to the cost to patients
of artemisinin monotherapy for ALL ORAL DOSAGE FORMS in private
for-profit outlets in 2010 US
dollars, at endline, 2011
............................................................................................................................
140
Table 2.3.14: Gross markup between purchase price and retail
selling price of non-artemisinin therapy at
baseline (2010) and endline (2011)
...........................................................................................................
142
Table 2.3.15: Gross markup between purchase price and retail
selling price of artemisinin monotherapy at
baseline (2010) and endline (2011)
...........................................................................................................
144
Table 2.3.16: Gross markup between purchase price and retail
selling price of non-quality-assured ACTs at
baseline (2010) and endline (2011)
...........................................................................................................
146
Table 2.3.17: Gross markup between purchase price and retail
selling price of quality-assured ACTs, at baseline
(2010) and endline (2011)
.........................................................................................................................
148
Table 2.3.18: Gross markup between purchase price and retail
selling price of quality-assured ACTs, by
presence of the AMFm logo, at endline, 2011
..........................................................................................
150
Table 2.3.19: Median total gross markup from first line buyer
price to retail selling price for quality-assured
ACTs bearing the AMFm logo, in 2010 US dollars, at endline, 2011
...................................................... 153
Table 2.3.20: Availability of any diagnostic test for malaria at
baseline (2010) and endline (2011) ................. 156
Table 2.3.21: Availability of malaria microscopy at baseline
(2010) and endline (2011) ..................................
158
Table 2.3.22: Availability of RDTs at baseline (2010) and
endline (2011)
........................................................ 160
Table 2.3.23: Cost to adult patients of malaria microscopy, in
2010 US dollars, at baseline (2010) and endline
(2011)
........................................................................................................................................................
162
Table 2.3.24: Cost to child patients of malaria microscopy, in
2010 US dollars, at baseline (2010) and endline
(2011)
........................................................................................................................................................
164
Table 2.3.25: Cost to adult patients of rapid diagnostic tests
for malaria (RDTs), in 2010 US dollars, at baseline
(2010) and endline (2011)
.........................................................................................................................
166
Table 2.3.26: Cost to child patients of rapid diagnostic tests
for malaria (RDTs), in 2010 US dollars, at baseline
(2010) and endline (2011)
.........................................................................................................................
168
Table 2.4.1: Percent distribution of antimalarial sales volumes
for public health facilities, at baseline (2010) and
endline (2011)
...........................................................................................................................................
173
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ix
Table 2.4.2: Percent distribution of antimalarial sales volumes
for private not-for-profit facilities, at baseline
(2010) and endline (2011)
.........................................................................................................................
174
Table 2.4.3: Percent distribution of antimalarial sales volumes
for private for-profit facilities, at baseline (2010)
and endline (2011)
....................................................................................................................................
175
Table 2.4.4: Percent distribution of antimalarial sales volumes
for all outlets (all sectors combined), at baseline
(2010) and endline (2011)
.........................................................................................................................
176
Table 2.4.5: Market share of quality-assured ACTs, by presence
of the AMFm logo at endline, 2011 ............. 177
Table 2.4.6: Percent distribution of antimalarial sales volumes
of ALL antimalarials by outlet type at baseline
(2010) and endline (2011)
.........................................................................................................................
178
Table 2.4.7: Percent distribution of antimalarial sales volumes
by private for-profit outlets by outlet type at
baseline (2010) and endline (2011)
...........................................................................................................
179
Table 2.4.8: Percent distribution of sales volumes of
quality-assured ACTs by outlet type at baseline (2010) and
endline (2011)
...........................................................................................................................................
180
Table 2.5.1: Provider knowledge of first line antimalarial
treatment at baseline (2010) and endline (2011) ..... 183
Table 2.5.2: Provider knowledge of dosing regimen for
quality-assured ACTs (QAACTs) for an adult, at
baseline (2010) and endline (2011)
...........................................................................................................
186
Table 2.5.3: Provider knowledge of dosing regimen for
quality-assured ACTs (QAACTs) for a child, at baseline
(2010) and endline (2011)
.........................................................................................................................
188
Table 2.5.4: Reasons for not stocking quality-assured ACTs
(QAACTs) for private providers, at baseline (2010)
and endline (2011)
....................................................................................................................................
191
Table 2.6.1: Provider recognition of AMFm logo, at baseline
(2010) and endline (2011) ................................. 195
Table 2.6.2: Provider knowledge of the meaning of the AMFm logo
at endline, 2011 ...................................... 197
Table 2.6.3: Sources from which providers have seen or heard of
the AMFm logo at endline, 2011 ................ 199
Table 2.6.4: Percentage of quality-assured ACTs bearing the AMFm
logo, at baseline (2010) and endline (2011)
..................................................................................................................................................................
201
Table 2.6.5: Percentage of all antimalarials other than
quality-assured ACTs bearing the AMFm logo, at
baseline (2010) and endline (2011)
...........................................................................................................
203
Table 2.6.6: Provider knowledge of the AMFm program at endline,
2011 ........................................................
205
Table 2.6.7: Sources from which providers heard of the AMFm
program at endline, 2011 .............................. 206
Table 2.6.8: Providers stating that there is a
maximum/recommended retail price (RRP) for antimalarials with
the AMFm logo at endline, 2011
..............................................................................................................
208
Table 2.6.9: Providers stating the correct maximum/recommended
retail price (RRP) for antimalarials with the
AMFm logo at endline, 2011
....................................................................................................................
209
Table 2.6.10: Providers who have received training on
antimalarials with the AMFm logo at endline, 2011 ... 210
Table 3.1.1: Prevalence of fever among children under five years
by selected background characteristics ....... 212
Table 3.2.1: Any antimalarial treatment of fever among children
under five years by selected background
characteristics
............................................................................................................................................
214
Table 3.2.2: ACT treatment among children under five years with
fever by selected background characteristics
..................................................................................................................................................................
216
Table 3.2.3: Prompt ACT treatment of fever among under five
children by selected background characteristics
..................................................................................................................................................................
219
Table 3.3.1: Diagnostic testing among children under five years
with fever by selected background
characteristics
............................................................................................................................................
221
Table 3.4.1: Treatment of fever among children under five years
from the poorest households (lowest two
wealth quintiles), by urban-rural residence
...............................................................................................
223
Table 4.1.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Ghana
........................................................................................................................................................
229
Table 4.2.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Kenya
........................................................................................................................................................
240
Table 4.3.1. Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Madagascar
...............................................................................................................................................
248
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x
Table 4.4.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in Niger
..................................................................................................................................................................
258
Table 4.5.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Nigeria.......................................................................................................................................................
267
Table 4.6.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Tanzania mainland
....................................................................................................................................
278
Table 4.7.1 Recommended retail prices for AMFm copaid ACTs in
2010 US dollars ...................................... 287
Table 4.7.2: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Uganda)
.....................................................................................................................................................
290
Table 4.8.1: Summary of key factors likely to have supported or
hindered achievement of AMFm goals in
Zanzibar
....................................................................................................................................................
300
Table 5.1.1: Number of remote area outlets enumerated and number
stocking antimalarials at the time of the
survey, according to country, 2011-2012
..................................................................................................
303
Table 5.1.2 Number of outlets in remote areas at endline by
final interview status, according to country, 2011-
2012
..........................................................................................................................................................
303
Table 5.1.3: Number of outlets enumerated by type of outlet in
remote areas at endline, according to country,
2011-2012
.................................................................................................................................................
304
Table 5.1.4: Number of outlets with antimalarials in stock by
type of outlet in the remote areas at endline,
according to country, 2011-2012
..............................................................................................................
304
Table 5.2.1: Outlets in remote areas and non-remote areas with
antimalarials in stock at endline, 2011-2012 . 306
Table 5.2.2:Outlets in remote areas and non-remote areas with
quality-assured ACTs in stock at endline, 2011-
2012
..........................................................................................................................................................
306
Table 5.2.3: Outlets in remote areas and non-remote areas with
quality-assured ACTs with the AMFm logo in
stock at endline, 2011-2012
......................................................................................................................
307
Table 5.2.4: Outlets in remote areas and non-remote areas with
stockouts of quality-assured ACTs at endline,
2011-2012
.................................................................................................................................................
308
Table 5.2.5: Percentage of the population living in subdistricts
in remote areas and non-remote areas with
outlets with quality-assured ACTs in stock at endline, 2011-2012
........................................................... 309
Table 5.3.1: Cost to patients of quality-assured ACTs (including
formulations for adults and children) in remote
areas and non-remote areas at endline, in US dollars, 2011-2012
............................................................
311
Table 5.3.2: Cost to patients of quality-assured ACTs (pediatric
formulations only) in remote areas and non-
remote areas at endline, in US dollars, 2011-2012
....................................................................................
312
Table 5.3.3: Cost to patients of non-quality-assured ACTs
(including formulations for adults and children) in
remote areas and non-remote areas at endline, in US dollars,
2011-2012 ................................................ 313
Table 5.4.1: Gross markup between purchase price and retail
selling price of quality-assured ACTs in remote
areas and non-remote areas at endline, in US dollars, 2011-2012
............................................................
315
Table 5.5.1: Availability of malaria diagnostic tests in remote
areas and non-remote areas at endline, 2011-2012
..................................................................................................................................................................
317
Table 5.5.2: Cost to patients of malaria diagnostic tests in
remote areas and non-remote areas at endline, in US
dollars, Kenya, 2011-2012
........................................................................................................................
318
Table 5.6.1: Percent distribution of antimalarial sales volumes
in remote areas and non-remote areas at endline,
2011-2012
.................................................................................................................................................
320
Table 5.7.1: Provider recognition of the AMFm logo in remote
areas and non-remote areas at endline, 2011-
2012
..........................................................................................................................................................
322
Table 5.7.2: Percentage of quality-assured ACTs bearing the AMFm
logo in remote areas and non-remote areas
at endline, 2011-2012
................................................................................................................................
322
Table 6.1.1: Number of individuals contacted by the interviewer
and the number who were interviewed by
urban/rural clusters, according to country, 2012
.......................................................................................
324
Table 6.1.2: Number of respondents by sex, age and urban/rural
cluster, according to country, 2012 .............. 325
Table 6.1.3: Reasons for choosing a malaria treatment
......................................................................................
326
Table 6.1.4: Source from which respondents had most recently
heard of ACTs ................................................
327
Table 6.1.5: Respondents who saw the AMFm logo in the outlet
they visited ...................................................
328
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xi
Table 6.1.6: Respondents who saw the AMFm logo in the outlet
they visited (among those who visited the outlet
to obtain an antimalarial)
..........................................................................................................................
329
Table 6.1.7: Source from which respondents have ever seen the
AMFm logo ...................................................
330
Table 6.1.8: Meaning of the AMFm logo: Respondents who have seen
the AMFm logo before ....................... 331
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xii
List of figures
Figure 1: Overview of the achievement of the AMFm Success
Benchmarks by county, indicating benchmarks
achieved (in green), nearly or possibly achieved (in amber) and
not achieved (in red), (point estimate, and
p-value for statistical test of whether the level stated in the
benchmark was achieved) ......................... xxiii Figure 2:
Timeline of AMFm Phase 1 Independent Evaluation data collection;
grant amendments and
disbursements; arrival in-country of copaid QAACTs; launch
events; IEC/ BCC implementation; and
application of demand levers by the Global Fund
...................................................................................
xxvii Figure 3: Breakdown of outlets stocking antimalarials by
outlet type at endline Figure ....................................
xxx Figure 4: Breakdown of private for-profit outlets stocking
antimalarials market structure by outlet type at
endline, 2011
............................................................................................................................................
xxxi Figure 5: Percentage of outlets with QAACTs in stock at
baseline and endline, and the Success Benchmark 1
threshold (20 percentage point increase in availability of
QAACTs) ..................................................... xxxii
Figure 6: Percentage of public health facilities and private
for-profit outlets with QAACTs in stock at baseline
and endlin
...............................................................................................................................................
xxxiii Figure 7: Percentage of outlets with QAACTs in stock in
urban and rural areas at baseline and endline ....... xxxiii Figure
8: Percentage of outlets with QAACTs in stock by presence of the
AMFm logo at endline ............... xxxiv Figure 9: Percentage of
outlets with oral AMT and non-artemisinin therapies in stock at
baseline and endline
................................................................................................................................................................
xxxv Figure 10. Median cost to patients of one adult equivalent
treatment dose (AETD) of QAACTs in public and
private for-profit outlets (2010 US dollar equivalent), at
baseline and endline ..................................... xxxvi
Figure 11. Median cost to patients of one AETD of QAACTs in private
for-profit outlets in rural and urban
areas (2010 US dollar equivalent), at baseline and endline
...................................................................
xxxvii Figure 12. Median cost to patients of one AETD of QAACTs in
private for-profit outlets by presence of the
AMFm logo (2010 US dollar equivalent), at baseline and endline
...................................................... xxxviii
Figure 13: Median cost to patients of one AETD of QAACTs with the
AMFm logo and the recommended retail
price in private for-profit outlets (2010 US dollar equivalent)
at endline ............................................ xxxviii
Figure 14: Median cost to patients in private for-profit outlets of
one AETD of QAACTs bearing the AMFm
logo compared with the cost per AETD of the most popular
antimalarial that is not a quality-assured ACT
(2010 US dollar equivalent) at endline, and the Success
Benchmark 2 threshold (median price ratio
-
xiii
Figure 24: Overview of the achievement of the AMFm Success
Benchmarks by county, indicating benchmarks
achieved (in green), nearly or possibly achieved (in amber) and
not achieved (in red), (point estimate, and
p-value for statistical test of whether the level stated in the
benchmark was achieved) Figure .............. lxviii Figure 1.2.1:
Artemether-lumefantrine: Relative percentage of pack sizes, pre-
and post-revision of co-payment
structure and introduction of levers
.............................................................................................................
16 Figure 1.2.2: Artesunate-Amodiaquine: Relative percentage of
pack sizes, pre- and post-revision of co-payment
structure and introduction of levers
.............................................................................................................
17 Figure 1.2.3: Timeline of AMFm Phase 1 Independent Evaluation
data collection; grant amendments and
disbursements; arrival in-country of copaid QAACTs; launch
events; IEC/ BCC implementation; and
application of demand levers by the Global Fund
.......................................................................................
19 Figure 1.3.1: Location of the AMFm Phase 1 countries
.......................................................................................
22 Figure 1.4.1: AMFm Phase 1 Results Framework
................................................................................................
33 Figure 1.4.2: AMFm Theory of Change
...............................................................................................................
35 Figure 1.4.3: The Independent Evaluation Design
...............................................................................................
37 Figure 1.4.4: AMFm logo
.....................................................................................................................................
38 Figure 1.6.1: Remoteness classification (quintiles) based on the
remoteness index, Kenya and Ghana .............. 57 Figure 1.6.2:
Remoteness classification map showing the location of clusters
sampled in the remote areas for the
AMFm Independent Evaluation remote area survey
...................................................................................
59 Figure 4.1.1:Timeline of key events related to AMFm
implementation process and context in Ghana ............. 230
Figure 4.2.1: Timeline of key events related to AMFm implementation
process and context in Kenya ............ 241 Figure 4.3.1:
Timeline of key events related to AMFm implementation process and
context in Madagascar ... 249 Figure 4.4.1: Timeline of key events
related to AMFm implementation process and context in Niger
............. 259 Figure 4.5.1: Timeline of key events related to
the AMFm implementation process and context in Nigeria ..... 268
Figure 4.6.1: Timeline of key events related to AMFm implementation
process and context in Tanzania
mainland
....................................................................................................................................................
279 Figure 4.7.1: Timeline of key events related to AMFm
implementation process and context Uganda .............. 291 Figure
4.8.1: Timeline of key events related to AMFm implementation
process and context in Zanzibar ........ 301 Figure 8.1.1: AMFm
success metrics scorecard Ghana
...................................................................................
344 Figure 8.2.1: AMFm success metrics scorecard Kenya
...................................................................................
352 Figure 8.3.1: AMFm success metrics scorecard Madagascar
..........................................................................
358 Figure 8.4.1: AMFm success metrics scorecard Niger
....................................................................................
364 Figure 8.5.1: AMFm success metrics scorecard Nigeria
.................................................................................
369 Figure 8.6.1: AMFm success metrics scorecard Tanzania mainland
............................................................... 375
Figure 8.7.1: AMFm success metrics scorecard Uganda
.................................................................................
381 Figure 8.8.1:AMFm success metrics scorecard Zanzibar
................................................................................
387 Figure 9.1.1: Overview of the achievement of the AMFm Success
Benchmarks by county, indicating
benchmarks achieved (in green), nearly or possibly achieved (in
amber) and not achieved (in red), (point
estimate, and p-value for statistical test of whether the level
stated in the benchmark was achieved) ..... 395
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xiv
List of abbreviations ACT Artemisinin-Based Combination
Therapy
ADDO Accredited Drug Dispensing Outlets
AETD Adult Equivalent Treatment Dose
AGOA Africa Growth Opportunity Act
AHC Ad Hoc Committee
AL Artemether-Lumefantrine
ALMA
AM
African Leaders Malaria Alliance
Antimalarial
AMT Artemisinin monotherapy
AMFm Affordable Medicines Facility malaria
AMFmCC AMFm Coordinating Committee
API Active Pharmaceutical Ingredient
ARI Acute Respiratory Infection
ASAQ Amodiaquine and Artesunate
BCC
CAPSS
Behavior change communication
Consortium for ACT Private Sector Subsidy
CCA Community Change Agent
CCM County Coordinating Mechanism
CEM Cohort Event Monitoring
CERMES Centre de Recherches Mdicales et Sanitaires
CHAG Christian Health Association of Ghana
CHAI Clinton Health Access Initiative
CHW Community Health Worker
CI Confidence Interval
CIERPA Centre International d'Etudes et de Recherches sur les
Populations Africaines
CIF Cost-Insurance-Freight
CMS Central Medical Stores
CP Condition Precedent
CPC Consumer Protection Council
CPD Continuing Professional Development
CRDH Centre de Recherche pour le Dveloppement Humain
CRS Catholic Relief Services
CSI Centre de Sant Intgr
DAMM Direction dAgence de Medicament de Madagascar
DCs Data Contributors
DFID Department for International Development
DHAP Dihydroartemisinin-Piperaquine
DHS Demographic and Health Survey
DLDB Duka la Dawa Baridi
DNDi Drugs for Neglected Diseases initiative
DOMC Division of Malaria Control
ERP Expert Review Panel
E2Pi Evidence to Policy Initiative
FBO Faith-Based Organization
-
xv
FCO Focal Coordinating Office
FGD Focus group discussion
FLB First Line Buyer
FMOH Federal Ministry of Health
FOB Free on Board
GDP Gross Domestic Product
Gh Ghana Cedis
GHS Ghana Health Service
Global Fund The Global Fund to Fight AIDS, Tuberculosis and
Malaria
GoU Government of Uganda
HAI Health Action International
HBC Home Based Care
HMM Home Management of Malaria
HPLC High-performance Liquid Chromatography
ICCM Integrated Community Care and Management
ICH The International Conference on Harmonisation of Technical
Requirements for
Registration of Pharmaceuticals for Human Use
IE Independent Evaluation/Evaluator
IEC Information, Education and Communication
IPT Intermittent Preventive Treatment
IMCI Integrated Management of Childhood Illnesses
IOM Institute of Medicine
IQR Interquartile Range
IRB Institutional Review Board
IRS Indoor Residual Spraying
IOM Institute of Medicine
ITN Insecticide-Treated Net
JHU Johns Hopkins University
JMS Joint Medical Stores
KAP Knowledge, Attitude, and Perception
KCM Kenya Country Mechanism
KEMSA Kenya Medical Supplies Agency
KII Key Informant Interview
LANSPEX Laboratoire National de Sant Publique et dExpertise
LCS Licensed Chemical Sellers
LFA Local Fund Agent
LGA Local Government Area
LLIN Long-lasting Insecticidal Net
LTR Local Technical Representative
LSHTM London School of Hygiene and Tropical Medicine
MEEDS Malaria Early Epidemic Detection System
MICC Malaria Interagency Coordinating Committee
MICS Multiple Indicator Cluster Survey
MIS Malaria Indicator Survey
MMV Medicines for Malaria Venture
MOF Ministry of Finance
MOFEA Ministry of Finance and Economic Affairs
-
xvi
MOH Ministry of Health
MoHSW Ministry of Health and Social Welfare
MOMS Ministry of Medical Services
MOPHS Ministry of Public Health and Sanitation
MSA Master Supply Agreement
MVU Mobile Video Unit
NAFDAC National Agency for Food and Drug Administration and
Control
nAT Non-Artemisinin Therapy
NDA National Drug Authority
NGO Nongovernmental Organization
NHIS National Health Insurance Scheme
NHS National Health System
NMCP National Malaria Control Program
NMS National Medical Stores
NOC National Oversight Committee
nQAACT Non-Quality-Assured Artemisinin-Based Combination
Therapy
NSA National Strategy Application
OJT On-the-Job Training
ONEN Organisation National des Educateurs Novateurs
OS Outlet survey
ONPPC Office National des Produits Pharmaceutiques et
Chimiques
OTC Over-the-Counter
PCN Pharmacists Council of Nigeria
PDA Personal Digital Assistant
PHCC Primary Health Care Center
PHCU Primary Health Care Unit
PMI Presidents Malaria Initiative
PNLP Programme National de Lutte contre le Paludisme
POM Prescription-Only Medicines
POP Part One Pharmacy
PPB Pharmacy & Poisons Board
PPS Probability Proportional to Size
PR Principal Recipient
PSI Population Services International
PSM Procurement Supply Management
PV Pharmacovigilance
PwC PricewaterhouseCoopers
QAACT Quality-Assured Artemisinin-Based Combination Therapy
QCIL Quality Chemicals Industries Limited
RBM Roll Back Malaria
RDT Rapid Diagnostic Test
RFP Request for Proposal
RMCG Role Model Care Givers
RMS Regional Medical Stores
RRP Recommended Retail Price
RSE Relative standard error
SADC Southern Africa Development Community
-
xvii
SC Steering Committee
SI Supporting Intervention
SMOH State Ministry of Health
SOP Standard Operating Procedures
SP Sulfadoxine-Pyrimethamine
SR Sub-Recipient
SSA sub-Saharan Africa
SSF Single Stream Funding
SuNMaP Support to National Malaria Control Program
SURE Securing Ugandans Rights to Essential Medicines
TANAM Tanzania National Malaria Movement
TERG Technical Evaluation Reference Group
TFDA Tanzania Food and Drug Authority
TLC Technologie de lInformation et de Communication
TWG Technical Working Group
TZ-RDIP Tanzania Remote Distribution Incentive Program
UGP Unit de Gestion de Projet
UN United Nations
UNDP United Nations Development Program
UNICEF United Nations Children's Fund
USD United States Dollar
VHT Village Health Team
VPP Voluntary Pooled Procurement
WHO World Health Organization
WHO/AFRO World Health Organization/Africa region
YGC Yakubu Gowon Centre
ZFDB Zanzibar Food and Drug Board
ZILS Zanzibar Integrated Logistics System
ZMCP Zanzibar Malaria Control Program
-
xviii
Definition of key terms Key terms Definition
Adult Equivalent Treatment
Dose (AETD)
An AETD is the number of milligrams (mg) of an antimalarial drug
needed to treat a 60 kg
adult.
Antimalarial Any medicine recognized by WHO for the treatment of
malaria. Medicines used solely for
the prevention of malaria are excluded from analysis in this
report.
Artemisinin-Based
Combination Therapy (ACT)
An antimalarial that combines artemisinin or one of its
derivatives with an antimalarial or
antimalarials of a different class.
Artemisinin monotherapy An antimalarial medicine that has a
single active compound, where this active compound is
artemisinin or one of its derivatives.
Booster Sample A booster sample is an extra sample of units (or
in this case outlets) of a type not adequately
represented in the main survey, but which are of special
interest.
In this survey, we have included a booster sample of public
health facilities and Part One
pharmacies in the entire district that includes the selected
subdistrict, consisting of all of the
public health facilities and Part One pharmacies in the district
that are not in the selected
subdistrict.
Censused subdistrict A subdistrict where field teams conducted a
full census of all outlets with the potential to sell
antimalarials.
Combination therapy The use of two or more classes of
antimalarial drugs/molecules in the treatment of malaria
that have independent modes of action.
Dosing/treatment regimen The posology or timing and number of
doses of an antimalarial used to treat malaria. This
schedule often varies by patient weight.
Enumerated Outlets Outlets that were visited by a member of one
of the field teams and from which at a
minimum basic descriptive information was collected (Sections
C1-C9 of the outlet survey
questionnaire).
First-line treatment The government-recommended treatment for
uncomplicated malaria.
Monotherapy An antimalarial medicine that has a single mode of
action. This may be a medicine with a
single active compound or a synergistic combination of two
compounds with related
mechanisms of action.
Non-artemisinin therapy An antimalarial medicine that does not
contain artemisinin or any of its derivatives.
Outlet Any point of sale or provision of a commodity to an
individual. Outlets are not restricted to
stationary points of sale and may include mobile units or
individuals.
Pediatric formulation Antimalarial drug packaged specifically
for children.
Quality-Assured
Artemisinin-Based
Combination Therapies
(QAACTs)
QAACTs are ACTs that comply with the Global Fund to Fight AIDS,
Tuberculosis and
Malarias Quality Assurance Policy.
For the purpose of the Independent Evaluation, a QAACT is any
ACT that appeared on the
Global Fund's indicative list of antimalarials meeting the
Global Fund's quality assurance
policy prior to baseline or endline data collection (see
http://www.theglobalfund.org/en/procurement/quality/pharmaceutical/#General),
or which
previously had C-status in an earlier Global Fund quality
assurance policy and was used in a
program supplying subsidized ACTs.
At baseline, QAACTs were defined as any ACT that appeared on the
Global Funds
indicative list of antimalarials meeting its quality assurance
policy as at June 2010, or which
previously had C-status in an earlier Global Fund quality
assurance policy and was used in a
program supplying subsidized ACTs.
At endline, QAACTs were defined as any ACT that appeared on the
Global Funds
indicative list of antimalarials meeting its quality assurance
policy as of September 2011, or
which previously had C-status in an earlier Global Fund quality
assurance policy and was
used in a program supplying subsidized ACTs.
Rapid-Diagnostic Test
(RDT) for malaria
A test used to confirm the presence of malaria parasites in a
patients bloodstream.
Screened An outlet that was administered the screening questions
(S1 to S4) of the outlet survey
questionnaire (see screening criteria).
Screening criteria The set of requirements that must be
satisfied before the full questionnaire is administered.
In this survey, an outlet met the screening criteria if (1) it
had antimalarials in stock at the
time of the survey visit, or (2) it reported having stocked them
in the past three months.
Subdistrict (SD)
The primary sampling unit, or cluster, for the outlet survey. It
is an administrative unit that
has a population size of approximately 10,000 to 15,000
inhabitants. These units frequently
are defined by geographical, health or political boundaries.
Treatment/dosing regimen The posology or timing and number of
doses of an antimalarial used to treat malaria. This
schedule often varies by patient weight.
http://www.theglobalfund.org/en/procurement/quality/pharmaceutical/#General
-
xix
Overview of the Independent Evaluation of AMFm
The success of malaria control efforts depends on a high level
of coverage in the use of
effective antimalarials such as artemisinin-based combination
therapies (ACTs). Although
these antimalarials have been procured in large amounts by
countries, evidence suggests that
ACT use still remains far below target levels. In response to
this issue, the Affordable
Medicines Facility malaria (AMFm) hosted by the Global Fund to
Fight AIDS,
Tuberculosis and Malaria (Global Fund) was set up. AMFm
comprises three key elements: (i)
price reductions through negotiations with ACT manufacturers;
(ii) a buyer subsidy through a
co-payment for ACTs at the top of the global supply chain; and
(iii) supporting
interventions to promote appropriate use of ACTs. Examples of
these supporting
interventions include training providers and outreach to
communities to promote ACT use.
All ACTs subsidized through AMFm bear a green leaf logo on their
packaging. The four
main objectives of AMFm are to: (i) increase ACT affordability;
(ii) increase ACT
availability; (iii) increase ACT use, including among vulnerable
groups; and (iv) crowd out
oral artemisinin monotherapies, chloroquine and
sulfadoxine-pyrimethamine (SP) by
increasing the market share for ACTs.
The Independent Evaluation of AMFm was designed to assess
whether, and to what extent,
AMFm Phase 1 achieves its objectives. The evaluation was carried
out in all of the currently
operational Phase 1 pilots (Ghana, Kenya, Madagascar, Niger,
Nigeria, Tanzania mainland,
Uganda, and Zanzibar). The evaluation is based on a
non-experimental design with a pre- and
post-test intervention assessment in which each participating
country is treated independently
as a case study. The evaluation includes two major components:
(1) a pre-intervention
(baseline) and post-intervention (endline) study of key outcomes
through nationally
representative outlet surveys and use of secondary household
survey data; and (2)
documentation of key features of the context at baseline and
endline and the AMFm
implementation process in each country. The results of the
outlet and household surveys are
compared to the AMFm success benchmarks (see Figure 1), and
interpreted using the process
and context data to facilitate interpretation of the changes in
outcomes over the
implementation period and to judge whether any observed changes
are likely to be due to
AMFm. Availability, price and market share benchmarks focus on
quality assured ACTs
(QAACTs) defined as products meeting the Global Funds quality
assurance criteria. (At the
time this report was written, no endline household survey data
were available to measure use
of ACTs to treat fever in young children, but it is expected
that household data will be
available for some countries before November 2012.) In addition,
two complementary studies
were carried out in selected countries at endline. The remote
area study examined the
availability, price and market share of ACTs at the end of the
main endline outlet survey in
areas considered remote and those considered non-remote. The
AMFm logo study assessed
whether or not the AMFm logo achieved its intended effect with
respect to public awareness
and marketing.
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A number of key findings can be distilled:
1. Achievement of success benchmarks Figure 1 provides an
overview of the
performance of each pilot against the AMFm success benchmarks.
Of the 8 pilots,
success benchmarks were clearly met in 5 pilots for
availability, 5 pilots for QAACT
price relative to the most popular antimalarial that is not a
QAACT, and 4 pilots for
QAACT market share (all shaded green). It is also possible that
benchmarks were met in
one additional pilot for availability and price, and in 3
additional pilots for market share,
although the evidence is not as strong (shaded amber). The
success benchmarks related to
artemisinin monotherapy (AMT) price and market share were met in
all pilots with
sufficient AMTs in the market to make these benchmarks
relevant.
2. AMFm and the private for-profit sector AMFm has been a game
changer in the
private for-profit sector for all pilots except Niger and
Madagascar, with a dramatic
impact on the antimalarial market, through large increases in
QAACT availability,
decreases in QAACT prices, and increases in QAACT market share.
These changes were
substantial and achieved in only a few months, demonstrating the
power of tapping into
the distributional capacity of the private sector. The changes
are very likely to be largely
attributable to AMFm. The private for-profit sector response was
similar in rural and
urban areas, in some cases reducing or closing a rural-urban gap
in availability and
market share. There was considerable penetration of copaid
QAACTs even in remote
areas in Ghana and Kenya, where this was evaluated.
3. AMFm and the public sector AMFm led to fewer fundamental
changes to public
sector antimalarial supply, where QAACT supply continued to be
hindered by problems
with procurement and grant requirements, leading to substantial
delays in ordering.
Increases in QAACT market share were seen in the public sector
in four pilots (Ghana,
Nigeria, Uganda and Zanzibar), although in Nigeria most QAACTs
distributed through
the public sector were not copaid. QAACTs were available in less
than 80% of all public
facilities at endline in five pilots, and there was generally no
change in public sector
QAACT prices as most countries already provided QAACTs for free
at baseline (except
Ghana where public sector QAACT prices fell).
4. Limited impact in Madagascar and Niger The impact of AMFm on
the private for-
profit sector was limited in Madagascar and Niger, where orders
of copaid ACTs were
very low. Explanations may include (i) the lack of full-scale
mass media campaigns; (ii)
the structure of the private for-profit antimalarial sector,
which had a much higher
proportion of general stores, and in Niger itinerant vendors,
who are not allowed to stock
QAACTs; and (iii) an unfavourable context of political and/or
economic instability and
severe weather conditions.
5. Effect of duration of implementation Longer duration of
implementation appears to
be positively correlated with performance, if the combined
presence of copaid ACTs and
the operation of a large-scale sustained IEC/BCC campaign is
considered a proxy for full
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AMFm implementation. With the exception of Zanzibar, pilots with
earlier start dates
achieved more success benchmarks. No large-scale sustained
IEC/BCC campaign was in
place by the end of 2011 in Madagascar, Niger or Uganda, and
these pilots achieved