Americord information kit

INFORMATION KITcordadvantage.com 866-503-6005

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INFORMATION KIT

Why AMeRIcORd?

Quality• The best quality guarantee in the industry –

$80,000• Registered with the FDA; AABB-accredited lab• We use FDA-approved cord blood bags

suitable for C-sections without adaptors• Executive Medical Director, Dr. Robert Draker,

is a leading hematologist and FDA Pediatrics Advisory Committee member

Service• 24/7 collection assistance for clients• No annual storage fees for 20 years• Cord tissue and placenta tissue banking

available• Bedside pickup provided by a medical courier

at no extra charge

PriceIncludes 20 years of storage - no annual fees• Cord blood banking - $1,999• Cord blood + tissue - $3,998 • Cord blood + cord tissue + placenta tissue -

$5,998

Umbilical cord blood stem cells are easy and painless to collect, easier to match (particularly with siblings), and very flexible in terms of the other types of cells they can become.

call 866-503-6005 to speak with a cord blood specialist today or visit us at cordadvantage.com

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Diseases treated using umbilical cord blood stem cells since 2008

dId yOU KNOW?

Stem cells are the body’s master cellsStem cells are valuable in medical procedures because they have the ability to differentiate (change into other types of cells in the body), which holds significant promise for improving the treatment of some of the most common diseases, such as heart disease, diabetes, and Parkinson’s disease, just to name a few.

cord blood is the most readily accessible source of stem cellsCord blood, which is found in the umbilical cord, is an easily accessible source of stem cells that is only available when a baby is born. The stem cells in the umbilical cord blood are genetically unique to your baby and family and may be used to treat various medical problems for your child, his or her siblings, and other family members.

The potential medical uses of stem cellsIn addition to the growing list of diseases currently being treated with stem cells, several medical research projects are showing encouraging results for new treatments.

• Stem cells have been “triggered” to differentiate into neural cells, which could lead to treatments for diseases such as Alzheimer’s and Parkinson’s.

• Stem cells have proven their ability to turn into blood vessel cells, which could someday benefit treatments for heart disease, allowing patients to essentially “grow their own bypass.”

• Stem cells have been labeled an important biological resource and researchers are conducting studies to unlock the potential of stem cells in future applications for diseases like diabetes, heart and liver disease, and muscular dystrophy, as well as for spinal cord injuries and stroke.

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cORd BlOOd BANK cOMPARISON*

dON’T TAKe OUR WORd FOR IT. heAR WhAT OUR cUSTOMeRS ThINK...

cORd BlOOd. SIMPlIFIed.

cRedeNTIAlS yOU cAN TRUST

AMeRIcORd RegISTRy

When I began researching cord blood banks, I wanted to find the one with the highest standards – even if that meant I had to pay more. What a great surprise to find out that I could get the best service and the highest quality at half the price with Americord!

We are dedicated to making cord blood banking simple by providing the highest quality cord blood banking services at the most affordable price. Our price includes everything you need.

• 20 years storage and medical courier• No hidden charges or annual fees• $1,999 for cord blood or $3,998 for

cord blood and tissue• We will match any competitor’s price

Americord is registered with the FDA and our laboratory is CLIA Certified, accredited by the AABB, and complies with all federal and state guidelines. We use the only cord blood collection bag approved by the FDA for all births, including C-sections. We use a medical courier to expedite delivery of your baby’s cord blood to our lab.

Americord collects, processes, and stores newborn stem cells from umbilical cord blood, cord tissue, and placenta tissue for future medical or therapeutic use, including the treatment of more than 80 diseases, such as sickle cell anemia and leukemia. Founded in 2008, Americord operates in all 50 states. Americord is headquartered in New York, NY.

I had a million questions about cord blood banking. The staff at Americord answered them all and even explained complicated things about stem cells in plain language. They also walked me through the different options and payment plans and helped me find the one that was right for me.

* ViaCord, CBR, Cryo-Cell, AlphaCord, StemCyte, and FamilyCord information is based on publicly available information from the Parent's Guide to Cord Blood Banking website as of 12/4/2012. Visit cordadvantage.com/product-comparison for more information.

Included $150 $150$150+ $400+ $200+Included

ViaCord

Total Cord Blood CostIncluding 20 years storage

CBR Cryo-Cell AlphaCord StemCyte FamilyCord

$1,999$4,625 $4,570 $4,245 $3,695

$4,675 $4,470

Total Cord Blood and Tissue CostIncluding 20 years storage

No Cancellation Fee

Quality Guarantee

Medical Courier Fee

$8,420 $7,655 $6,849$7,970

$3,998

$80,000 $25,000 $50,000 $50,000 $50,000

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Cord tissue refers to the tissue of the umbilical cord. Until recently, cord tissue was often discarded after birth, but new research has shown that the stem cells found in cord tissue have the potential to treat many diseases. Cord tissue contains a specific kind of stem cell, called mesenchymal stem cells (MSCs). Unlike the stem cells that are collected from cord blood MSCs collected from cord tissue are multipotent, which means they have the capacity to differentiate into many different types of cells, including cartilage cells (chondrocytes), bone cells (osteoblasts), and fat cells (adipocytes). This characteristic of MSCs means that they could potentially be used to treat a wide range of diseases.

cORd BlOOd vS. cORd TISSUe

The stem cells in cord blood and cord tissue function differently. Cord blood contains hematopoietic stem cells (HSCs), which form the blood-related cells in the body, such as white blood cells, red blood cells, and platelets. There are over 80 diseases that have been treated using HSCs and almost 200 clinical trials are currently under way. Cord tissue contains stem cells known as mesenchymal stem cells (MSCs), which develop into structural and connective tissue. There are currently over 40 clinical trials under way investigating the potential therapeutic applications of MSCs from cord tissue.

POTeNTIAl USeS

Though no conditions have been treated using mesenchymal stem cells (MSCs), there are over 40 clinical trials under way. These clinical trials are exploring the possibility of using MSCs for the following:

• Cartilage repair• Liver disease• Diabetes• Stroke• Heart disease• Serious wounds• Human Immunodeficiency Virus (HIV)• Spinal cord injury

Cord blood banking, cord tissue banking, or placenta tissue banking does not guarantee that the saved cells will be applicable for every situation.

Ultimate use will be determined by a physician. Please note: Americord Registry’s activities are limited to collection of umbilical cord tissue from

autogeneic donors. Americord Registry’s possession of a New York State license for such collection does not indicate approval or endorsement of

possible future uses or future suitability of cells derived from umbilical cord tissue.

What is cord Tissue?

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Number of Clinical Trials Involving Cord Tissue Since 2008

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The placenta is a stem cell rich tissue that protects the developing fetus in the womb. Stem cells from placenta tissue are “immune-privileged,” meaning they are unlikely to be rejected by human immune systems because they would never be recognized as a foreign body. Cord blood, which is found in the umbilical cord, contains hematopoietic stem cells (HSCs); umbilical cord tissue contains mesenchymal stem cells (MSCs). Placenta tissue contains both HSCs and MSCs; in addition, the placenta contains pluripotent stem cells, which are able to differentiate into almost any cell within the body. Because pluripotent stem cells can develop into almost any cell, their use is constantly being researched for the generation of new healthy cells that can replace diseased cells.

Pluripotent Stem cells

Placenta tissue has been shown to be a rich source of pluripotent stem cells, or cells that have the potential to differentiate into any cell in the body. This encompasses the cells that multipotent stem cells can differentiate into, but the differentiation potential of pluripotent stem cells is extended to include cells of the brain, lung, and liver. Pluripotent stem cells can be harvested and used to regenerate virtually any cell. Because of this, pluripotent stem cells from from placenta tissue hold the promise of someday being able to treat many neurological, respiratory, and metabolic disorders.

hematopoietic Stem cells

Like cord blood, the tissue of the placenta is a rich source of hematopoietic stem cells (HSCs). HSCs are cells that differentiate into blood-borne cells like red blood cells, white blood cells, and platelets. Just like those derived from bone marrow and cord blood, HSCs from the placenta can be used to treat over 80 diseases, including genetic disorders and cancers.

Mesenchymal Stem cells

Placenta tissue is also an abundant source of mesenchymal stem cells (MSCs). Unlike HSCs, MSCs are multipotent, which means they can differentiate into a broader range of cells, including cartilage cells, bone cells, and fat cells.

The potential therapeutic application of MSCs to treat disease is currently the topic of many research studies, with over 40 clinical trials under way. MSC research has helped progress efforts to cure many still untreatable diseases.

What is the

Placenta?

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Why cORd BlOOd STeM cellS ARe BeTTeR

Doctors may choose to use cord blood stem cells over bone marrow or peripheral blood stem cells because of better survival outcomes. Cord blood stem cells are easier to match and present a lower chance of resulting in graft-versus-host-disease (“GVHD”).

More Tolerant Matching

A close match between the patient and the donor can improve a patient’s outcome after transplant. Bone marrow is difficult to match because it requires a “perfect match” between the donor and recipient. Cord blood stem cells, however, are less mature than those in bone marrow and can be successfully used even when there is only a half-match. This means there is more opportunity for transplants between family members when cord blood is banked. Some studies have shown that overall survival rates for transplants between relatives are more than double that of transplants from unrelated donors.

less graft-versus-host disease

Graft-versus-host disease (“GVHD”) is a common complication after an allogeneic transplant, which uses cells from a family member or unrelated donor. GVHD can range from mild to life threatening. Studies have found that fewer patients get GVHD after a cord blood transplant than do after bone marrow or peripheral blood transplants.

cOllecTINg cORd BlOOd, cORd TISSUe, ANd PlAceNTA TISSUe IS SAFe

Stem cells from cord blood, cord tissue, and placenta tisse are collected after your baby is born and the umbilical cord has been cut. The collection of stem cells is painless, easy, and safe

for mother and baby. Cord blood, cord tissue, and placenta tissue collection will not alter the normal birthing process in any way. The average collection time is about 5 to 10 minutes and is performed by your medical professional.

cOllecTION AFTeR c-SecTIONS

Stem cells can be collected from the umbilical cord after C-section deliveries. Americord uses the only FDA-approved sterile exterior cord blood collection bag that has been approved for ALL births, including C-sections, without adaptors.

WhO ShOUld cONSIdeR PRIvATe cORd BlOOd BANKINg?

Saving stem cells is a once in a lifetime opportunity to expand your baby’s options for medical treatment. Everyone can benefit from cord blood banking. It is often referred to as biological insurance that hopefully you will never need. And with the rapid pace of medical advancement, the value of banking your baby’s cord blood increases with time.

!

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It is prudent for parents to bank their baby’s cord blood if either parent has a family history of a disease that is treatable with stem cells, such as leukemia, lymphoma, or myeloma. It has also been reported that ethnic minorities and people of mixed ethnicity have greater difficulty finding a match from stem cell donors, which makes private banking an important opportunity. Cord blood stems cells can be used to treat certain genetic diseases, including sickle cell anemia and thalassemia, which are more common in certain ethnic populations.

Families preparing to adopt a newborn should consider saving stem cells since, if they are ever needed, the cord blood may be the only available genetic source of stem cells for the adopted baby. In addition, if the baby’s family medical history is not available, stem cells might provide valuable medical information. Similarly, couples using fertility treatments that involve a donor egg and/or sperm should consider banking cord blood stem cells because this may be the only opportunity to secure a genetically related sample of stem cells for their child.

cORd BlOOd BANKINg cONTROveRSy

Cord blood banking gives parents-to-be the best opportunity to offer their babies access to the most advanced medical treatments, should they ever need them. However, some people consider cord blood banking controversial.

It is true that the likelihood of using stem cells is very small. Banking stem cells from cord blood is often referred to as biological insurance. It is an investment that puts the benefits of cutting-edge scientific advances at your disposal. And, as medical research continues to uncover new uses of stem cells, the likelihood that the stem cells could be used increases.

Some believe that public banking is better. Americord supports the availability of public cord blood banking. However, private cord blood banking offers advantages that

public cord blood banking does not offer. Specifically, only through private cord blood banking are you guaranteed immediate access to your baby’s own stem cells. This means that you do not have to spend time searching for a match, nor

do you risk not finding a match.

Private cord blood banking is an additional expense that comes at a time when many parents-to-be are thinking about other expenses, like the

child’s education or moving to a larger home. Americord is a strong advocate for making cord blood banking affordable for everyone. We suspect that insurance companies will help to cover the cost of private cord blood banking in the future. We are also committed to continuing to offer programs where we donate cord blood banking services to low-income families. And, as more parents elect to bank cord blood, the costs will come down.

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TOP BeNeFITS OF PRIvATe cORd BlOOd BANKINg

A guaranteed Match

When you bank your baby’s cord blood you can rest easy knowing that if he or she ever needs a medical treatment that uses stem cells, you have an exact match.

Quickly Available

Banking your baby’s cord blood ensures that these stem cells can be immediately available if they are needed for treatment. A cord blood unit can be delivered from Americord’s storage facility to a medical facility in less than two weeks. It can take two months or more to find an unrelated cord blood, bone marrow, or peripheral blood donor through a public bank.

SelecTINg A cORd BlOOd BANK

Once you have made a decision to privately bank your baby’s cord blood, you will need to choose which cord blood bank to use. Here are some of the key facts that you will want to consider:

• Is the cord blood bank registered with the FDA, accredited with the AABB, and licensed by the state’s department of health?

• How and when is the cord blood collection kit delivered to you?

• How quickly will the cord blood be transferred to the laboratory for processing?

• Does the manufacturer of the cord blood collection kit have a substantial track record in the field?

• Does the collection kit contain everything that your medical practitioner will need to collect the cord blood and package it for pickup by the courier?

• Does the cord blood collection kit contain clear instructions so you know what to do with it after the cord blood has been collected?

• Does the cord blood bank use a medical courier service?

• Is the laboratory where the cord blood is processed appropriately accredited?

• What is the laboratory’s reputation in the industry?

• Is the stem cell storage facility used by the cord blood bank appropriately accredited?

• What is the stem cell storage facility’s reputation in the industry?

• Does the cord blood bank have a customer service hotline that is available 24/7 for any questions related to cord blood collection and stem cell retrieval?

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AMeRIcORd’S execUTIve MedIcAl dIRecTOR

Dr. Robert Dracker, a leading hematologist, pediatric oncologist, and recognized blood and stem cell banking expert, is Americord’s Executive Medical Director. He is responsible for all laboratory, collection, and transport protocols and procedures, as well as licensing and accreditation. He is also responsible for quality controls and advising Americord on all scientific and medical matters. Dr. Dracker previously served as Executive Medical Director for ViaCord until 2007. He was also the Medical Director of Biocyte, the cord blood company that facilitated the first cord blood transplant in the United States. The cord blood collection and processing procedures established by Biocyte (now known as PharmaStem) during Dr. Dracker’s tenure are still used throughout the industry today. He was also part of the Working Group on Cord Blood Stem Cell Guidelines for New York State and, as the Chairperson of the Hematopoietic Progenitor Cell Committee for the NY State Department of Health, an architect of the New York cord blood banking licensing requirements, which are considered to be the gold standard of cord blood banking accreditations. Dr. Dracker was recently named as a consultant to the Food and Drug Administration’s (“FDA’s”) Pediatric Advisory Committee, which makes recommendations to the Commissioner of Food and Drugs regarding research priorities, among other responsibilities.

AMeRIcORd’S cRedeNTIAlS ANd PROTOcOlS

Americord is a private cord blood bank that processes and stores newborns’ stem cells from cord blood, cord tissue, and the placenta for future medical or therapeutic use. We are the only private cord blood bank headquartered in New York City. We are deeply committed to offering our clients the most valuable and scientifically advanced stem cell preservation service in the marketplace. Americord is registered with the FDA and the company’s laboratory is accredited by the AABB. Our Executive Medical Director, Dr. Dracker, is responsible for all laboratory, collection, and transport protocols and procedures, as well as licensing and accreditation. Americord has developed the highest quality protocols for every step of the process involved in the collection and storage of cord blood, cord tissue, and placenta tissue from newborns.

WheN yOU ShOUld decIde ABOUT cORd BlOOd BANKINg

Half of all babies arrive before their due date, so Americord recommends making a decision about cord blood banking during your second trimester, if possible. However, it’s never too late in your pregnancy to enroll.

eNROllMeNT

Enrollment is quick and easy. Americord offers two methods for your convenience: online at cordadvantage.com/enroll or by phone at 866-503-6005 extension 1.

Dr. Robert Dracker

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The AMeRIcORd cOllecTION KIT

Americord clients receive an Americord Collection Kit shortly after enrollment. The Collection Kit contains all of the material your medical

practitioner will need to collect your baby’s cord blood. It also contains a pre-labeled box that will be picked up by our medical courier. The phone number to arrange for courier pickup is on the box. The umbilical cord blood collection bag that is included in the Americord Collection Kit has become the industry standard and is backed by standard operating procedures and clinical outcomes from the NIH COBLT study. The Cord Blood Sterile Collection Bag is FDA-approved and designed to maximize the recovery of cell-rich plasma. These sets are manufactured using validated manufacturing processes that ensure safe, consistent, and reliable product performance. Each transplant bag is 100% inspected prior to release. Your baby’s Collection Kit is assigned a unique identifier that always remains with your baby’s Collection Kit, paperwork and sample. Additionally, a client ID label, which clearly identifies the client, is attached to each sample.

WheN yOUR BABy IS BORN

After your medical practitioner has made the collection using the Americord Collection Kit, the labor and delivery staff will return the Collection Kit to you or to a designated family member. The Collection Kit is pre-labeled and is ready to be shipped. Simply call Americord after your baby’s birth, and then relax with your new baby. Your Collection Kit will be picked up by our medical courier directly from your hospital room. After the medical courier picks up the Collection Kit, Americord will monitor your shipment until it is safely delivered to our lab. While many other cord banks readily accept samples delivered after 72 hours, this reduces the viability of the samples considerably; therefore Americord aims to have the Collection Kit back to our laboratory within 24 hours or as quickly as possible. Unlike other banks that use regular courier services, Americord only uses couriers that are trained to handle time sensitive medical shipments using a consistent chain-of-custody. Americord’s medical courier service is open and fully staffed 24 hours a day, 365 days a year. No matter when you deliver, your baby’s Collection Kit is shipped under highly controlled conditions to our cord blood laboratory.

AFTeR yOUR BABy IS BORN

Your baby’s stem cells are processed the same day your collection kit is received in our AABB-accredited laboratory, even if it happens to be a holiday. Stem cell samples are tested for cell viability, total nucleated cell count (TNC), sterility, infectious disease markers, number of stem cells, and blood type. All processing and testing is performed following rigorous quality assurance procedures and under the supervision of experienced staff. Laboratory staff is made up of highly experienced health professionals and technicians who work under the guidance and expertise of our Executive Medical Director. This ensures that Americord delivers the cutting-edge of new cord blood advances, while guaranteeing the safety, integrity, and viability of your baby’s stem cells. Americord tests incoming cord blood samples before and after processing as part of our quality control to ensure that each sample is contaminant-free on arrival and continues to be during processing in our laboratory. Our screening exceeds FDA regulations for testing and quality control.

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STeM cellS IN STORAge

Maintaining the viability and health of your baby’s stem cells throughout processing requires careful lowering of the temperature prior to freezing and storage. Once the stem cells are

brought to the optimum temperature, they are placed in a storage cartridge and then into a storage tank. Units are kept in designated freezers in a specifically designated storage area. Our AABB-accredited laboratory’s sophisticated coding system offers easy and precise access to your cord blood stem cells, should your family ever need them.

Americord uses Cook General BioTechnology LLC (“CGBT”) for all processing and storage of cord blood. CGBT was founded in 1997 and is registered with the FDA as a Human Cell & Tissue Products establishment. Its umbilical cord blood processing laboratories are licensed in New York, New Jersey, California, Maryland and Indiana. Its facility, which is designed to meet and exceed the needs of its customers, has been designed with features that include: multi-layer intrusion monitoring and video surveillance; emergency power from an independent generator and a backup generator; smoke, water, and fire detection monitoring; telephony for monitoring systems; reliable freezer temperature monitoring; stand-by ULT and LN2 freezers; equipment calibrated with NIST traceable probes; facility ambient temperature control; UPS battery backup systems for sensitive equipment.

When you enroll with Americord we ask you for your e-mail address, mailing address, and phone number. Your baby’s Certificate of Storage will arrive via e-mail within one week. Should the need arise for you to use your baby’s cord blood stem cells, Americord’s client services department and your physician will make arrangements for confirmatory testing, release, and transportation of your baby’s stem cells to a designated hospital.

ReFeRRAl PROgRAM

Americord clients are encouraged to share their decision and experience with others. When you refer your friends and family members to Americord you will receive a $50 gift card and the person you refer will receive a $50 discount.

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AMeRIcORd’S $80,000 QUAlITy gUARANTee

QUA

LITY GUARANTEE

$80,000

This guarantee is subject to the terms detailed in the enrollment agreement.

As a valued Americord client, the viability

of your baby’s umbilical cord blood stem

cells is backed by our $80,000 Quality

Guarantee. If your child’s cord blood unit is

used in a stem cell transplant and the cells

fail to engraft, Americord will pay $80,000

towards the cost of procuring stem cells

from an alternative source.

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WelcOMe TO AMeRIcORd RegISTRy

Thank you for taking the time to read through our information kit, we hope it answered all of your questions. I’m proud that Americord Registry is the fastest growing, most competitive, and highest quality cord blood bank in the industry.

You will soon be welcoming a new baby to this world and we want to make sure that you can do so with the confidence of knowing that you’ve done everything possible to ensure a healthy future for your child. It is our goal that you can do this at an affordable price. Please, do your research and if cord blood banking seems like the right decision for your family, we will be here to make things easy for you.

You should note that Americord Registry is like no other cord blood bank in the world. We follow all of the best practices, and meet or beat all industry standards. We offer the highest quality guarantee at $80,000, an amount that has still not been matched by any of our competitors. We have the lowest prices for both cord blood and cord tissue banking, and promise to meet any other cord blood bank’s prices that beat our advertised price. We don’t charge an annual storage fee for 20 years and we wait until we have verified that each cord blood collection exceeds strict industry benchmarks for cell count, volume, and condition before charging our clients. Enrollment in Americord is risk-free. We do not charge a cancellation fee if you decide not to bank your baby’s cord blood. And you can change your product selection at any time since our 3-in-1-collection kit comes with the equipment necessary to collect stem cells from cord blood, cord tissue, and placenta tissue.

Thank you once again for considering Americord. We hope to be able to serve you and your family.

Martin SmithmyerPresident and CEOAmericord

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Acute Lymphoblastic Leukemia Acute Myelogenous Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia

Chronic Myelogenous Leukemia Chronic Lymphocytic Leukemia Juvenile Chronic Myelogenous Leukemia Juvenile Myelomonocytic Leukemia

Refractory Anemia Refractory Anemia with Ringed Sideroblasts Refractory Anemia with Excess Blasts Refractory Anemia with Excess Blasts in Transformation Chronic Myelomonocytic Leukemia

Hodgkin's Lymphoma

Beta Thalassemia Major (also known as Cooley's Anemia) Blackfan-Diamond Anemia Pure Red Cell Aplasia Sickle Cell Disease

Severe Aplastic Anemia Congenital Dyserythropoietic Anemia Fanconi Anemia Pure Red Cell Aplasia

Amegakaryocytosis / Congenital Thrombocytopenia Glanzmann Thrombasthenia

Acute Myelofibrosis Agnogenic Myeloid Metaplasia (Myelofibrosis)Polycythemia Vera Essential Thrombocythemia

Severe Combined Immunodeficiency (SCID) SCID with Adenosine Deaminase Deficiency SCID which is X-linkedSCID with absence of T & B Cells SCID with absence of T Cells , Normal B Cells Omenn Syndrome

Kostmann SyndromeMyelokathexis

Ataxia-Telangiectasia Bare Lymphocyte Syndrome Common Variable Immunodeficiency

Leukemias

Lymphomas

Inherited Red Cell (Erythrocyte) Abnormalities

Other Disorders of Blood Cell Proliferation

Acute Leukemia

Chronic Leukemia

Myelodysplastic Syndromes (sometimes called pre-leukemia)

Anemias

Inherited Platelet Abnormalities

Myeloproliferative Disorders

Inherited Immune System Disorders

Inherited Immune System Disorders – Neutropenias

Inherited Immune System Disorders – Other

••••

••••

•••••

•••

••••

••••

••

••••

••••••

••

• • •

DiGeorge Syndrome Leukocyte Adhesion Deficiency Lymphoproliferative Disorders Lymphoproliferative Disorder, X-linked (also known as

EpsteinBarr Virus Susceptibility) Wiskott-Aldrich Syndrome

Chediak-Higashi Syndrome Chronic Granulomatous Disease Neutrophil Actin Deficiency Reticular Dysgenesis

Multiple Myeloma Plasma Cell Leukemia Waldenstrom's Macroglobulinemia

Neuroblastoma Retinoblastoma

Cartilage-Hair Hypoplasia Gunther's Disease (Erythropoietic Porphyria) Hermansky-Pudlak Syndrome Pearson's Syndrome Shwachman-Diamond Syndrome Systemic Mastocytosis

Mucopolysaccharidoses Storage Diseases Mucopolysaccharidoses (MPS) Hurler's Syndrome (MPS-IH) Scheie Syndrome (MPS-IS) Hunter's Syndrome (MPS-II) Sanfilippo Syndrome (MPS-III) Morquio Syndrome (MPS-IV) Maroteaux-Lamy Syndrome (MPS-VI) Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII) Mucolipidosis II (I-cell Disease)

Adrenoleukodystrophy (ALD)/Adrenomyeloneuropathy (AMN)Krabbe Disease (Globoid Cell Leukodystrophy) Metachromatic Leukodystrophy Pelizaeus-Merzbacher Disease

Gaucher Disease Niemann-Pick Disease Sandhoff Disease Tay-Sachs Disease Wolman Disease

Cancers in the Bone Marrow

Solid Tumors

Transplants for Inherited Disorders Affecting the Immune System & Other Organs

Inherited Immune System Disorders – Other

Phagocyte Disorders

Transplants for Inherited Metabolic Disorders

Leukodystrophy Disorders

Lysosomal Storage Diseases

Inherited Disorders – OtherLesch-Nyhan Syndrome

• • • •

•

• •• •

• • •

• •

•• • • • •

• • • • • • • • • •

•• • •

• • • • •

• • Osteopetrosis

dISeASeS TReATed WITh cORd BlOOd STeM cellS

Non-Hodgkin's Lymphoma Burkitt's Lymphoma Non-Hodgkin's Lymphoma Burkitt's Lymphoma

Source: Parent’s Guide to Cord Blood Foundation as of March 07, 2010. Please visit their web site for the most current and comprehensive information.

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hUMAN clINIcAl TRIAlS exPeRIMeNTAl TReATMeNTS

Crohn's Disease Diabetes, Type 1 (formerly called Juvenile Diabetes) Lupus

Cerebral Palsy, Hypoxia, Encephalopathy Multiple Sclerosis Traumatic Brain Injury Spinal Cord Injury

Cystic Fibrosis Histiocytic Disorders:

Familial Erythrophagocytic Lymphohistiocytosis Hemophagocytosis Langerhans Cell Histiocytosis (LCH; formerly called Histiocytosis-X)

Epidermolysis Bullosa

Glanzmann Thrombasthenia Severe Combined Immunodeficiency (SCID) SCID with Adenosine Deaminase Deficiency (ADA-SCID) SCID which is X-linked Beta-Thalassemia Wiskott-Aldrich Syndrome

Myocardial Infarction Angina Cardiomyopathy

Breast Cancer Ewing's Sarcoma Renal Cell Carcinoma

Restoring vision by growing a new cornea Restoring vision by treating macular degeneration

ooo

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••••

••

•

••••••

•••

•••

••

Auto-Immune Diseases

Repair of the Nervous System

Disorders of Cell Proliferation or Metabolism

Gene Therapy

Cardiac Therapy

Transplants for Cancerous Tumors

Organ Repair

Arthritis, Juvenile Arthritis, Rheumatoid Evan Syndrome Juvenile Dermatomyositis Scleroderma

Fanconi's Anemia (using genetically modified cord blood from the same person)

Metabolic Disorders Parkinson's Disease

Duchenne Muscular Dystrophyuchenne Muscular Dystrophy Amyotrophic Lateral Sclerosis (ALS, or "Lou Gehrig's disease") Alzheimer's Disease Huntington's Disease Parkinson's Disease

Hearing loss Stroke recovery

Combined transplant of kidney plus hematopoietic stem cells Growth of renal cells from adult stem cells

Growth of liver cells from cord blood stem cells Repair of liver cirrhosis with cord blood stem cells

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•

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• Growth of airway epithelia from stem cells in bone marrow

Auto-Immune Diseases

Gene Therapy

Nerve Cell Repair

Organ Repair

Diseases of the Central Nervous System

Other forms of nerve damage

Kidney

Liver

Lungs

Fanconi's Anemia (using genetically modified cord blood

Source: Parent’s Guide to Cord Blood Foundation as of March 07, 2010. Please visit their web site for the most current and comprehensive information.