1 Title: Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation Cathrine Petersen 1 , Amber L. Nolan 1 , Elisa de Paula França Resende 1,2 , Zachary Miller 1 , Alexander J. Ehrenberg 1 , Maria Luisa Gorno-Tempini 1 , Howard J. Rosen 1 , Joel H. Kramer 1 , Salvatore Spina 1 , Gil D. Rabinovici 1 , Bruce L. Miller 1 , William W. Seeley 1 , Helmut Heinsen 3,4 , Lea T. Grinberg 1,2,5 1 Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco 2 Global Brain Health Institute based at University of California, San Francisco and Trinity College, Dublin 3 LIM-44, University of Sao Paulo Medical School, Sao Paulo, Brazil. 4 Clinic of Psychiatry, University of Würzburg, Wurzburg, Germany 5 LIM-22, Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil. Key words: Alzheimer’s disease; neurofibrillary tangles; atypical Alzheimer’s disease; tau pathology; autopsy; human Send correspondence to: Lea Tenenholz Grinberg, MD, PhD, Associate Professor in Residence Memory and Aging Center, Department of Neurology Sandler Neurosciences Center, Box 1207 675 Nelson Rising Lane, Room 211B San Francisco, CA 94158 E-mail: [email protected] Telephone: +1 415-502-7229 Acknowledgments This study was supported by the National Institute of Health grant K24AG053435 and institutional grants P50AG023501, P01AG019724. MLGT was funded by the National Institute of Health grants K24DC015544A and R01NS50915. The authors have no duality or conflicts of interest to declare. certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not this version posted April 9, 2019. ; https://doi.org/10.1101/538496 doi: bioRxiv preprint
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