-רררר- 1 -רררר- 1 Normal values of pulmonary Normal values of pulmonary artery pressure in young artery pressure in young healthy subjects – are healthy subjects – are values similar to the values similar to the general population general population ? ? Alon Grossman Alon Grossman 1 1 , Alex Prokupetz , Alex Prokupetz 1 , Ori Wand , Ori Wand 1 , , Amit Assa Amit Assa 1 ,Michal Benderly ,Michal Benderly 2 2 , , Ofra Kalter- Ofra Kalter- Leibovici Leibovici 2 1. Aeromedical Center, Israeli Air Force 1. Aeromedical Center, Israeli Air Force 2 2 . . The Gertner Institute for epidemiology and healthy The Gertner Institute for epidemiology and healthy policy research affiliated to Tel Aviv University,Tel policy research affiliated to Tel Aviv University,Tel Hashomer,Israel Hashomer,Israel 1
Normal values of pulmonary artery pressure in young healthy subjects – are values similar to the general population?. Alon Grossman 1 , Alex Prokupetz 1 , Ori Wand 1 , Amit Assa 1 ,Michal Benderly 2 , Ofra Kalter-Leibovici 2 1. Aeromedical Center, Israeli Air Force - PowerPoint PPT Presentation
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1-שמור- 1-שמור-
Normal values of pulmonary Normal values of pulmonary artery pressure in young artery pressure in young
healthy subjects – are values healthy subjects – are values similar to the general similar to the general
populationpopulation??
Alon GrossmanAlon Grossman1 1 , Alex Prokupetz, Alex Prokupetz11, Ori Wand, Ori Wand11,,Amit AssaAmit Assa11 ,Michal Benderly ,Michal Benderly2 2 ,, Ofra Kalter-Ofra Kalter-
LeiboviciLeibovici22
1. Aeromedical Center, Israeli Air Force1. Aeromedical Center, Israeli Air Force
22 . .The Gertner Institute for epidemiology and healthy policy The Gertner Institute for epidemiology and healthy policy research affiliated to Tel Aviv University,Tel Hashomer,Israelresearch affiliated to Tel Aviv University,Tel Hashomer,Israel
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Cardiovascular assessment has Cardiovascular assessment has major implication in the medical major implication in the medical screening process of aircrew screening process of aircrew candidates.candidates.
BackgroundBackground
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Cardiovascular screening in the Cardiovascular screening in the Israeli Air Force includes:Israeli Air Force includes: Medical and family historyMedical and family history Physical examinationPhysical examination ElectrocardiogramElectrocardiogram EchocardiographyEchocardiography
BackgroundBackground
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TTE has been validated for the TTE has been validated for the noninvasive assessment of cardiac noninvasive assessment of cardiac structure and function.structure and function.
TR jet peak velocity predicts PASP TR jet peak velocity predicts PASP observed by invasive measurements.observed by invasive measurements.
Normal upper limit of PASP is lower than Normal upper limit of PASP is lower than 30mmHg in studies.30mmHg in studies.
95%95% limit for PASP was 29+5mmHg limit for PASP was 29+5mmHg (34 mmHg).(34 mmHg).
Upper that Upper that 99%99% limit for PASP limit for PASP was 34+5mmHg (39 mmHg).was 34+5mmHg (39 mmHg).
PASP was correlated with the LVEDPASP was correlated with the LVED and LVES.and LVES.
PASP – Pulmonary Artery Systolic PressurePASP – Pulmonary Artery Systolic PressureLVED – Left Ventricular End Diastolic DiameterLVED – Left Ventricular End Diastolic Diameter
LVES - Left Ventricular End Systolic DiameterLVES - Left Ventricular End Systolic Diameter
ResultsResults
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Previous studies among normal and Previous studies among normal and heterogeneity population the PASP was heterogeneity population the PASP was reported 26.6-29.3mmHg.reported 26.6-29.3mmHg.
AgeAge is the strongest predictor of PASP, is the strongest predictor of PASP, increase of 1mmHg for every decade of increase of 1mmHg for every decade of age .age .
It is crucial to determine the normal It is crucial to determine the normal range of PASP.range of PASP.
PASP values may be high as 40mmHq in PASP values may be high as 40mmHq in general population, include obese and general population, include obese and elderly subjects.elderly subjects.
The values of PASP was 34mmHq in 95The values of PASP was 34mmHq in 95thth % % of the subjects in our study.of the subjects in our study.
Higher PASP values may be present in Higher PASP values may be present in young athletes subjects.young athletes subjects.
A previous study found a correlation A previous study found a correlation between BSA and BP and PASP.between BSA and BP and PASP.
In our study a correlation was found In our study a correlation was found between LVED and LVES and PASP.between LVED and LVES and PASP.
PASP – Pulmonary Artery Systolic PressurePASP – Pulmonary Artery Systolic PressureBSA – Body Surface AreaBSA – Body Surface Area
BP – Blood PressureBP – Blood PressureLVED – Left Ventricular End Diastolic DiameterLVED – Left Ventricular End Diastolic Diameter
LVES - Left Ventricular End Systolic DiameterLVES - Left Ventricular End Systolic Diameter
DiscussionDiscussion
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The subjects were evaluated at a The subjects were evaluated at a single time point and no follow-up single time point and no follow-up was performed.was performed.
Population evaluated is a highly Population evaluated is a highly selected one, thus preventing selected one, thus preventing generalization to other populations.generalization to other populations.
Study limitationStudy limitation
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Values of PASP in young healthy Values of PASP in young healthy subjects may be higher than those subjects may be higher than those observed in the general population.observed in the general population.