ALLERGY IN ALABAMA ALLERGY IN ALABAMA SPRING - FLOWERING GRASSES, SPRING - FLOWERING GRASSES, ORNAMENTAL FLOWERS, NOT PINE POLLEN ORNAMENTAL FLOWERS, NOT PINE POLLEN FALL – RAGWEED NOT GOLDENROD FALL – RAGWEED NOT GOLDENROD YEAR ROUND-ANIMAL YEAR ROUND-ANIMAL DANDER AND SALIVA DANDER AND SALIVA SUMMER/HUMIDITY -MOLDS/ FUNGUS SUMMER/HUMIDITY -MOLDS/ FUNGUS
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ALLERGY IN ALABAMA n SPRING - FLOWERING GRASSES, ORNAMENTAL FLOWERS, NOT PINE POLLEN n FALL – RAGWEED NOT GOLDENROD n YEAR ROUND-ANIMAL DANDER AND SALIVA.
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ALLERGY IN ALABAMAALLERGY IN ALABAMA
SPRING - FLOWERING GRASSES, SPRING - FLOWERING GRASSES, ORNAMENTAL FLOWERS, NOT PINE ORNAMENTAL FLOWERS, NOT PINE POLLENPOLLEN
FALL – RAGWEED NOT GOLDENRODFALL – RAGWEED NOT GOLDENROD YEAR ROUND-ANIMALYEAR ROUND-ANIMAL DANDER AND DANDER AND
STAGES OF ALLERGIC DISEASESTAGES OF ALLERGIC DISEASE
EARLY PHASEEARLY PHASE MAST CELLS AND PRODUCTSMAST CELLS AND PRODUCTS
LATE PHASELATE PHASE LEUKOCYTESLEUKOCYTES T -LYMPHOCYTEST -LYMPHOCYTES
CHRONIC PHASECHRONIC PHASE T CELLS FACTORST CELLS FACTORS
MAST CELLSMAST CELLS
DIFFERENT TYPES OF MAST CELLSDIFFERENT TYPES OF MAST CELLS CHYMASE POSITIVECHYMASE POSITIVE TYPTASE POSITIVE (all mast cells, most TYPTASE POSITIVE (all mast cells, most
common ocular surface, prevents clotting) common ocular surface, prevents clotting) CHYMASE AND TYPTASE (most CHYMASE AND TYPTASE (most
common in non allergic)common in non allergic)
calcium
Inside Mast Cells
Increase synthesis of phosopholipase A-Increase synthesis of phosopholipase A-production of arachodonic acidproduction of arachodonic acid
Increase protein kinase production-Increase protein kinase production-necessary for degranulationnecessary for degranulation
Increase in intracellular calcium levelsIncrease in intracellular calcium levels 24-48 hours increase cytokine production24-48 hours increase cytokine production
MAJOR BASIC PROTEIN (anti-parasite)MAJOR BASIC PROTEIN (anti-parasite) HIGHLY TOXIC TO EPITHELIUMHIGHLY TOXIC TO EPITHELIUM INCREASES MAST CELL INCREASES MAST CELL
DEGRANULATIONDEGRANULATION EOSINOPHIL CATIONIC PROTEINEOSINOPHIL CATIONIC PROTEIN EOSINOPHIL PEROXIDASE EOSINOPHIL PEROXIDASE
CONJUNCTIVAL CHALLENGE FDA REQUIREMENT FOR NEW DRUGSFDA REQUIREMENT FOR NEW DRUGS ALLERGEN APPLIED TO CONJALLERGEN APPLIED TO CONJ REDNESS,WATERING,CHEMOSIS REDNESS,WATERING,CHEMOSIS
GRADEDGRADED RETEST WITH PRETREATMENTRETEST WITH PRETREATMENT