Alexander Vinogradov

7/27/2019 Alexander Vinogradov

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NON-INVASIVE CANCER

DIAGNOSTIC METHOD

AND

EQUIPMENT


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AUTHORS:

Deltatekh Ltd MSU Science Park

Alexander V Vinogradov Alekxey I Trushin

Leonid Z Velsher Mikhail L Stakhanov

Central Clinical Hospital2 name after Semashko N.A.

Russian Railroads.

Moscow State Medical-Stomatological University

*


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Deltatekh LTD

Key Project Firm

Image capture and processing systems

Spectroscopy instruments

Medical diagnostic equipment Scientific devices

Deltatekh LTD, MSU Science Park, Vorobyevi Gory, Moscow, Russia, 119 899 Tel/fax+07:(095)930-8409

Since 1992 MSU Science Park

www.deltatekh.ru 930-8409


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Imaging System

Matrix-430k/12Futures

Super-high sensitivity Wide Spectral range

Nanosecond resolution

High spatial resolution

Applications

Medical imaging

Scientific

measurements

FISH-microscopy


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Posttraumatic hand wound fluorescent

image

(5 days after the trauma)


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The method is based on selective

accumulation of endogenous porphyrinsin quickly growing tissues (proliferation

areas).

Cancer is most proliferation area.

Proliferation areas are identified by

recording laser-fluorescent images.


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As known, cells of a malignant tumorshare essentially more often normal

cells. Thus growth rate of different

tumors, as well as speed of duplicationvarious on the structure normal (non

tumor) cells is rather various. Hence

estimating intensity of fluorescent

radiation endogenous (natural)

porthyrins it is possible to judgemorphology of researched fabrics

precisely to a certain extent.


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The Block-diagram of excitation and

registration fluorescent emission

Human

bodytissue

Laser

emission

and image

registratio

n system

Red laser light (50 mkWt/sm2, =635 nm)Fluorescence emission =650-700 nm

Fluorescence emission =650-700 nm


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The method andprototypes of the

equipment used in

medical practice byCentral ClinicalHospital2

Russian Railroadsmore then 7 years.

Pilot version of the diagnostic system


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Fluorescent image of the patients face

(upper part)


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To the left of tumor it is clearly visible tumoral

defeat of a skin.


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Bright spot - basal cells cancers relapse onthe temple.


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The same patient after tumour removing


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Operational wound after

laser removal of that tumor

Relapse of basal sells cancer

after surgical removal


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Breaking up black cancer

skin (the central form)

984 3007Fluorescence intensity:


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Skin cancer LIF diagnostic Statistical results

Correct

91%

False-

egative

9%


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Patent Shield

Patents of RF No. 2128005, No.2169922, PCT patent application No.PCT/RU99/00039, international

publication No. WO 00/47112, USAPatent No. US 6,584,342 B1(Jun,24,2003), Canadian patent

application No 2,360,229, EPO patentapplication No. 99921306.9


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Market Size Estimations

Russian Federation- $57-80M

US and Canada - $650-800M

Global market -$2-3B


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The Project Aims

To enter the market of medicalequipment for laser-fluorescent cancerdiagnostics;

To spread application methods(education, certification of specialists,licensing).


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Market Entry

Establishing a company for equipmentproduction and distribution.

Authors of the project join the company as apartner by granting IPR (patents, know-how,software, results of clinical trials, drafts,

schemes, software, A-prototype). Investorsgrant financial capital and other asset.


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Project Expanses Consulting & global markets estimations

Start-up Company Establishing, Legal documents

Rent, CEO end workers salary

Company style design & Public Relations

Expensed Equipment & Software

Market sample design & production 10 pieces Device and method Certification & national market clinical

trials

Marketing & Advertising


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Time and Money

Financial capital $3-5M

Time to market - 18-24 month


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Our Team


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BIO 2007 Boston, USA, May 2007

Forums


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Grand Prix on VIII International ForumHigh Technology of XXI April 2007

Moscow

Awards

Alexander Vinogradov

Documents