Alcohol has the largest death rate out of all other drugs disorders caused by alcohol have increased over the past 6 years Null Hypothesis: the ethanol exposure will have no effect on the short term memory of Drosophila melanogaster. Alternate Hypothesis: the Drosophila exposed to ethanol will have impaired short term memory, and the Drosophila who are not, will not The purpose of this experiment is to demonstrate the effects of alcohol exposure on short term memory in drosophila. Alcohol Short Term Memory http://www.bcm.edu/labs/davis/researchprojects.htm Olfactory training http://www.jpp.krakow.pl/journal/archive/1203_s4/gfx/rys16_2.jpg Holly LaFerriere 2007 http://www.northwestern.edu/neurobiology/faculty/allada2/gbbpapers/ MooreHeberlein98.pdf Comparison between Control and chpd Drosophila Control and chpd Moore, 98 Need Knowledge Base Literature Review Purpos e Hypothesi s
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Alcohol has the largest death rate out of all other drugs
disorders caused by alcohol have increased over the past 6 years
Null Hypothesis: the ethanol exposure will have no effect on the short term memory of
Drosophila melanogaster.
Alternate Hypothesis: the Drosophila exposed to ethanol will have impaired
short term memory, and the Drosophila who are not, will not
The purpose of this experiment is to demonstrate the effects of alcohol exposure on short term memory in
The Effects of Alcohol on Short Term Memory in Drosophila
50.5
7.810.8
-30
-20
-10
0
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20
30
40
50
60
70
80
control Alcohol Before Alcohol After
Groups
Perf
orm
an
ce I
nd
ex
Wild Type Drosophila
ControlAlcohol Before
Alcohol After
Exposed to Alcohol for 5 minutes
Trained in olfactory method with one
minute shock increments every
10 minutes
Trained in olfactory method with one
minute shock increments every
10 minutes
Trained in olfactory method with one
minute shock increments every
10 minutesExposed to Alcohol for
5 minutes
Training Chamber
Tested 5 hours laterTested 5 hours later
Tested 5 hours later
Methodology
Results
Data Supported the Alternate Hypothesis
Effects of alcohol on long term memory.
Bayard, Max. "Alcohol Withdrawal Syndrome - March 15, 2004 - American Family Physician." American Academy of Family Physicians. 2004. 25 May 2009 <http://www.aafp.org/afp/20040315/1443.html>.
Ericson, Nels. "Substance Abuse:The Nation’s Number One Health Problem." 2001. U.S. Department of Justice. <http://www.ncjrs.gov/pdffiles1/ojjdp/fs200117.pdf>.
Farr, Susan. "Drinking for just eight weeks impairs learning and memory in mice." Science, Industry and Business: the innovations-report. 15 May 2009 <http://www.innovations-report.com/html/reports/life_sciences/report-45402.html>.
Grant B, Harford TC, Dawson DA, et al. Prevalence of DSM-IV alcohol abuse and dependence, United States 1992. Alcohol Health & Research World 18(3). 1994.
Laferriere, Holly, and Douglas J. Guarnieri. "Genetic Dissociation of Ethanol Sensitivity and Memory Formation in Drosophila melanogaster." (2008). Genetics. <http://www.genetics.org/cgi/content/full/178/4/1895/>.
Miller, Loren L., and Michael P. Dolan. "SpringerLink - Journal Article." SpringerLink Home - Main. 1973. <http://www.springerlink.com/content/u0161w1781274g83/>.
Moore, Monica, and Jim DeZazzo. "Ethanol Intoxication in Drosophila:Genetic and Pharmacological Evidence for Regulation by the cAMP Signaling Pathway." (1998). <http://www.northwestern.edu/neurobiology/faculty/allada2/gbbpapers/MooreHeberlein98.pdf>.
The number of trials for drosophila exposed to alcohol could have been higher and possible human errors.
Performance Index: (Correct-Incorrect)-.5/.5 x100
Ethanol beaker
Air pump
Alcohol Exposure
Exposure chamber
The purpose of this experiment is to demonstrate the effects of alcohol exposure on short term memory in drosophila.
Results demonstrated that exposure to alcohol impaired short term memory