AL44387-08.2020 – HiPP GmbH & Co. Vertrieb KG, Georg-Hipp-Straße 7, 85276 Pfaffenhofen (Ilm) References: 1 EFSA Panel on Dietetic Products, Nutrition and Allergies. EFSA Journal 2013; 11: 3408 2 Claßen M. pädiatrie hautnah 2014; 26: 90–92 3 Vandenplas Y et al. Eur J Pediatr 2014; 173: 1365–1371 4 Akkermans et al. Am J Clin Nutr 2017; 105(2):391–399 5 Chouraquai J-P et al. Nutrients 2019; 11, 2213 6 Hower J et al. Eur J Pediatr 2013; 172(12): 1597–605 7 Ghisolfi J et al. Public Health Nutr 2013; 16(3): 524–34 8 Lovell et al. Br J Nutr 2019; 121(6): 678–687 9 Walton J and Flynn A. Food Nutr Res. 2013; 57. doi: 10.3402/fnr. v57i0.21836. eCollection 2013 10 Hojsak I et al. JPGN 2018; 66: 177–85 11 Land C. Kinder- und Jugendmedizin 2012; 12: 174–180 12 Reinehr T et al. Monatsschr Kinderheilkd 2018; 166:814 13 Koletzko B et al. Monatsschr Kinderheilkd 2018; 166, 62 14 Suthutvoravut U et al. Ann Nutr Metab. 2015; 67(2): 119–132 * HiPP COMBIOTIC® Growing-up Milk 2+ with 2.9 μg/100 ml vitamin D ** Breast milk contains a large number of natural cultures that can vary from mother to mother *** Galacto-oligosaccharides obtained from lactose HiPP COMBIOTIC® Growing-up Milk hcp.hipp.com Composition meets current recommendations Reduced protein and fat content to suit the needs of children Specially adapted amounts of critical nutrients + + Iron + + Iodine + + Vitamin D - - Protein - - Saturated fatty acids Benefits demonstrated in study* Improved nutrient supply from drinking growing-up milk Significantly improved vitamin D levels in winter and safe to consume in summer Contains proven ingredients Contains proven ingredients Lactic acid culture L. fermentum (originally obtained from breast milk)** Valuable GOS fibres*** C o m p o s i t i o n m e e t s r e c o m m e n d a t i o n s ENA HiPP COMBIOTIC® Growing-up Milk meets the current recommendations: 13,14 *Higher vitamin D content based on clinical study 6 Nutrients/ criteria ENA recommendations 14 HiPP COMBIOTIC® Growing-up Milk from 1 year HiPP COMBIOTIC® Growing-up Milk from 2 years Flavouring no flavouring no flavouring no flavouring Preparation prepared in a cup prepared in a cup prepared in a cup Composition per 100 kcal Energy (kcal/100 ml) 45 – 70 51 51 Fat (g) 4.4 - 6.0 5.5 5.5 – DHA (% of fat) ideal value min. 0.3 0.3 0.3 Carbohydrates (g) 9 – 14 9.8 10.0 Protein (g) 1.6 – 2.7 2.0 1.9 Vitamin D (μg) 1.5 – 4.5 4.5 5.7 * Calcium (mg) min. 200 235.3 235.3 Iron (mg) 1 – 3 2.4 2.4 Iodine (μg) 12 – 36 27.5 27.5 Calcium, potassium, magnesium, vitamin B 2 and B 12 content replicate that of whole milk and energy content replicates that of semi-skimmed cow’s milk No flavourings or sweeteners used Protein content lower than in cow’s milk HiPP COMBIOTIC® Growing-up Milk 1+ and 2+ meet the recommendations of the Early Nutrition Academy (ENA) Nutrient supply during toddlerhood Information for healthcare professionals For healthy growth all the way up to nursery-school age HiPP COMBIOTIC® Growing-up Milk M e e t s E N A r e c o m m e n d a t i o n s New recipe Composition of HiPP COMBIOTIC® Growing-up Milk for children aged 1 and over and aged 2 and over compared to recommendations from the Early Nutrition Academy (ENA)
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AL4
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References:1 EFSA Panel on Dietetic Products, Nutrition and Allergies. EFSA
Journal 2013; 11: 3408
2 Claßen M. pädiatrie hautnah 2014; 26: 90–92
3 Vandenplas Y et al. Eur J Pediatr 2014; 173: 1365–1371
4 Akkermans et al. Am J Clin Nutr 2017; 105(2):391–399
obtained from breast milk)** Valuable GOS � bres***
Composition meets
recommen d a t i o n s
ENA
HiPP COMBIOTIC® Growing-up Milk meets the current recommendations: 13,14
* Higher vitamin D content based on clinical study6
Nutrients/criteria ENA recommendations14
HiPP COMBIOTIC®Growing-up Milk
from 1 year
HiPP COMBIOTIC®Growing-up Milk
from 2 years
Flavouring no � avouring no � avouring no � avouring
Preparation prepared in a cup
prepared in a cup
prepared in a cup
Composition per 100 kcal
Energy (kcal/100 ml) 45 – 70 51 51
Fat (g) 4.4 - 6.0 5.5 5.5
– DHA (% of fat) ideal value min. 0.3 0.3 0.3
Carbohydrates (g) 9 – 14 9.8 10.0
Protein (g) 1.6 – 2.7 2.0 1.9
Vitamin D (µg) 1.5 – 4.5 4.5 5.7 *
Calcium (mg) min. 200 235.3 235.3
Iron (mg) 1 – 3 2.4 2.4
Iodine (µg) 12 – 36 27.5 27.5
Calcium, potassium, magnesium, vitamin B2 and B12 content replicate that of whole milk and energy content replicates that of semi-skimmed cow’s milk
No flavourings or sweeteners used
Protein content lower than in cow’s milk
HiPP COMBIOTIC® Growing-up Milk 1+ and 2+ meet the recommendations of the Early Nutrition Academy (ENA)
Nutrient supply during toddlerhood
Information for healthcare professionals
For healthy growth all the way up to nursery-school age
HiPP COMBIOTIC® Growing-up Milk
Meets ENA
recommendations
Newrecipe
Composition of HiPP COMBIOTIC® Growing-up Milk for children aged 1 and over and aged 2 and over compared to recommendations from the Early Nutrition Academy (ENA)
Supply status using blood levels Calculated nutrient supply
Adequate supply of vitamin D for toddlers is important for:
Bones and teeth
The immune system
Possible protective e� ects for type I/II diabetes, cardiovascular and autoimmune diseases and tu-mours11
Why is vitamin D in particular so critical?
End of supplementation after their second early summer, subsequent supply is inadequate12
Insufficient vitamin D content in food
Limited self-synthesis due to strong sun protection
Endogenous synthesis is insufficient to compensate for low intake via diet
In the EFSA report, the toddlers’ diets included:
Protein intake approximately 12 to 19 energy per cent (E%) above average requirements
Intake of important fatty acids below adequate intake (AI)
Average ALA intake below or exactly at recommended 0.5 E%
Average DHA intake of 43 mg/d, signi� cantly less than AI of 100 mg/d
In almost all surveys, iron intake was below AI of 8 mg
Infants and toddlers are at risk of iodine de� ciency
Prevalence of vitamin D de� ciency between 10 and 30%
Experts call for:
Improved quality of toddler nutrition through appropriate interventions2
Di� cult to implement in practice as it requires changes to eating habits 3
A European Food Safety Authority (EFSA) report has shown that nutrient supply is suboptimal in European toddlers1
Growing-up milk improves the supply of critical nutrients
Overview of studies on improved nutrient intake/supply from drinking growing-up milk
Vitamin D Iron Vitamin C Zinc Protein Alpha-linolenicacid
Essentialfattyacids
Vitamin A Vitamin E B vitamins
Akkermans et al. 2017 4
Chouraquai et al. 2019 5
Hower et al. 2013 6
Ghisol� et al. 2013 7
Lovell et al. 2019 8
Walton and Flynn 2013 9
Growing-up milk is developed to meet the specific needs of toddlers:
Higher amounts of nutrients which are often not consumed in sufficient quantities
Other nutrients replicate those found in cow’s milk
Reduced protein content to suit children’s needs
Various studies on humans have investigated the extent to which growing-up milkcontributes to nutrition.
Multiple clinical studies have shown that nutrient intake/supply is improved by drinking growing-up milk.
This applies in particular to the supply of
vitamin A, C, D und E,
omega-3 fatty acids,
iron and zinc.
Particularly critical: Vitamin D
Signi� cantly higher 25(OH)D serum concentrations in the growing-up milk group (with average intake of 7.1 μg or 284 IU/day)
The intervention study also showed that growing-up milk is safe to use in summer (median 25(OH)D serum concentrations: 27.6 ng/ml)
European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) thus recommends:Growing-up milk can be used as part of a strategy to increase the intake of iron, vitamin D, and polyunsaturated fatty acids and decrease the intake of protein compared with unforti� ed cow’s milk.10
Growing-up milk with 2.9 μg vitamin D per 100 ml is a safe and simple way to prevent the decrease in 25(OH)D serum concentration during the winter.
Vitamin D supply when consuming growing-up milk versus cow’s milk 6
Cow´s milk HiPP Growing-up milk * p<0.001 versus cow’s milk
Before winter(October)
n = 80
After winter (February)
n = 63
30
25
20
15
10
5
0
Study group: children 2-6 years old,HiPP Growing-up milk 2+ with 2.9 g vitamin D/100 ml = 116 IU,