Aim: How does the shape of the protein determine its function ?

Aim: How does the shape of the protein determine its function ?

HW 10

Text read pages 346-348

Pg 348 ans Q# 2,3

Messenger RNA

Transfer RNA

mRNA Start codon

Ribosome

Methionine

Phenylalanine tRNALysine

Nucleus

mRNA

Go to Section:

Transcription and Translation

Transcription

• DNA is copied in the nucleus

• Complimentary strand is mRNA

Adenine (DNA and RNA)Cystosine (DNA and RNA)Guanine(DNA and RNA)Thymine (DNA only)Uracil (RNA only)

The Polypeptide “Assembly Line”

mRNARibosome

Translation direction

Lysine tRNA

tRNA

Ribosome

Growing polypeptide chain

mRNA

Completing the Polypeptide.

Section 12-3

Go to Section:

Translation

The characteristics of a cell depends upon the proteins that are synthesized

Normal Hemoglobin

Sickle Cell hemoglobin

Normal rbc Sickle rbc

What is the function of rbc, how is the function affected ?

Inheritance of Sickle Trait

Reading for Sickle Cell Diseasehttp://genetics-education-partnership.mbt.washington.edu/class/activities/HS/sickle-back.htm

HBB: The Gene Associated with Sickle Cell Anemia

Official Gene Symbol: HBB

Name of Gene Product: hemoglobin, beta

Alternate Name of Gene Product: beta globin

Locus: 11p15.5 - The HBB gene is found in region 15.5 on the short (p) arm of human chromosome 11.

Bone marrow transplant can cure Sickle Cell Anemia

Sickle Cell Information Center News Page

• This procedure replaces bone marrow affected by sickle cell anemia with healthy bone marrow from a donor who doesn't have the disease. It can be a cure, but the procedure is risky, and it's difficult to find suitable donors. Researchers are still studying bone marrow transplants for people with sickle cell anemia. Currently, the procedure is recommended only for people who have significant symptoms and problems from sickle cell anemia.

• Back to the question:

How does the shape of the protein determine its function ? (refer to the shape of the protein hemoglobin in sickle cell)