AI based cervical cancer remote read-out system ... - aidot

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Cerviray AI protects women’s

health from cervical cancer

AI based cervical cancer remote read-out system

Cerviray AI

Cerviray AI

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AI-Based Cervical cancer remote read-out system

Cerviray portable colposcope + AI Software

Pre-labled database from University Hospitals

(i.e Seoul National Univ., Korea Univ. Hospital)

Patented AI algorithm AidotNet v1.2

(Sensitivity 93%, Specificity 89%)+ AI software

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Green filter

Convenient settingWireless transfer

Picture album

The most advanced portability and affordability

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Portable colposcope spec.

Platform Spec Note

OSWindows VistaSP2 or laterAndroid 8.0 or later

Compatible with both PCs and tablets

.Net framework 4.0 or later

CPU Intel Dual core or higher

Memory 1GB or more

Storage 1GB or more

ResolutionPC version : Variable type Android Version : 1920 x 1200

AI Framework TensorFlow

AI Network AIDOTNet v1.2

Self - develope AI speciallzed for cervical cancerSensitivity : 93%Specificity : 89%

AI Software spec.

Technical Data

Display 5" 720*1280 IPS LCD + Touch Screen

Image Sensor1/2.8 8.29 Mega-pixelCMOS Image Sensor

Zoom Optical 3X ~ 5X

Focus Auto + Manual

F No F3.2 ~ F3.7

Effective image Circle diameter Φ5.92mm

Distance Sensor TOF

CPU Dual core ARM cortex-A7 CPU

RAM DDR3 2G RAM

The most advanced portability and affordability

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All untrained HCP can screen the cervical dysplasia andcancer with remote consultation

ReportThe remote consultation

report can be sent

immediately

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CervirayWeb Admin

· Sensitivity 93%

· Specificity 89%

· TTACertified Test Report

Server

A.I. initial diagnosis2

Normal

CIN 1

CIN 2,3

CIN 3+

Cervirayfor Experts

Remote consultationPhysicians can give the remoteconsultation

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Picture1Image can taken by

any HCP at anywhere

Cerviray for Patients

Repeat the

Deep-LearningThe accuracy increase continuously

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Cerviray Hand-held Colposcope

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Micro SD card

Optical zoom lens

Shoot button

Battery

Wireless transfer

Green filter

Convenient setting

Auto focus

Picture album

Cerviray AI embedded

LCD touch screen

Power On/Off

Zoom / Focus

Cerviray AI Software

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AIDOTNet v1.2 Structure

Input Layer(224*224)

Conv. #1(54*54)

Max.Pooling

Max.Pooling

Conv. #2(26*26)

DeConv. #3(12*12)

Conv. #3(12*12)

DeConv. #4(12*12)

Conv. #4(12*12)

Max.Pooling

DeConv. #6(4096)

DeConv. #7(4096)

DeConv. #7(4096)

DeConv. #5(12*12)

Conv. #5(12*12)

Add Layer(5*5)

DropOut

DropOut

Fully Convolution Network(FCN)

Output

+

Pre-labled database by university hospitals

ClinicalKnowledge

Apply

Database

KFDA Level 3

Normal

CIN 1

Sensitivity : Max 93%

Specificity : Max 89%

AidotNet v1.2 ; the patented algorithm for cervical cancer

KFDA level 3 (export)

Cerviray AI Software

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Gorund Truth

(OB/GYN Dr.’s screening)

AI’s screening result

(Blind test)

On-site reading function

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2.

1.

Select On-site Reading

5. Print report

Photographing the cervix

3. Refer to the initial AI result

Only 1 ~ 5 min.

4. Final Reading Handling

Remote reading function

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2.

1.

Select Remote Reading

5. Print report

Photographing the cervix

3. Send patient informationand cervical images(request reading)

- Gynecology cacer gynecology oncologist

- Uterine Colposcopy Diagnostic Expert

- Assistant Professor of Obstetrics and Gynecology at Korea University Anam Hospital

- Full member of the Korean Society of Obstetrics and Gynecology

- Full member of the Korean Women’s Cancer Society

- Full member of the Korean Society of Obstetrics and Gynecology and Endoscopy

- Full member of the Korean Cancer Society

- Training member of the Korea Society for Oncology and Cancer

- Prevention Committee of the Korean Society for Gynecological Cancer

- An academic member of the Korean Society of Obstetrics and Gynecology.

- permanent member of the Korean Medical Laser Society

Song Jae-yun

(Professor of Korea UniversityAnam Hospital)

Director of the doctorgroup for reading

4. Show the results of thefirst reading by AI

Domestic or intercontinentalremote consultaion

Clinical Benefits

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Faster and Higher accuracy, portability, affordability

Cytology VIA Colposcopy

Based on IFCPC(The International Federation ofCervical Pathology and Colposcopy) nomenclature

A day

Online remote reading

No Infra(visual inspection)

Accuracy 90%

Cytology

7 to 30 days

Read after sampledelivery

High Infra costs(laboratory)

false negative rate 55%

Cerviray AI

Clinical Benefits

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Cerviray AI solution enables all Healthcare Professionals toimplement early screening without the barrier of training and cost

Importance of VIA and Cerviray AI’s solution to solve the problem

(Source: Cervical cancer screening and management of cervical pre-cancers, WHO, 2017)

HPV DNA test

� Scrubbing the uterine cervix cells

with a tool to collect a sample

� Samples are kept and sending to the lab

VIA

(Visual Inspection with Acetic acid,Colposcopy)

Visually observed after reacting 3~5%

acetic acid

Detect the lesion of dysplasia and cancer

by morphology

Cytology (Pap smear, LBC)

� Scrubbing the uterine cervix cells with a

tool to collect a sample

� Dedicated pathology resource can do

� Scrubbing process is simple

� Just send the sample to the Lab

� Need dedicated Lab resources

� High cost of Lab resource

� Diagnosis price is also high

� Difficulty in sample logistics

� Need long term training

Less than 1 min. for AI screening

Remote read-out by a doctor

� High price of equipment(Colposcope)

AI embedded in the super portable

colposcope (max. 1/10 lower price)

� Women are uncomfortable for the test

Remote read-out by a doctor

� Widely used in countries with good

medical care conditions

� Well known test method

� High false negative rate (up to 50%)

� Need dedicated resources

� High cost of resource

� Diagnosis price is also high

� Difficulty in sample logistics

� Simple inspection method

� Affordable

� Immediate result

� No infrastructure required

� Proven accuracy

� Can reduce unnecessary pathology

test and cost

Test Method Remark Problems and AIDOT’s solution

Clinical Benefits

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Comparison Chart

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Clinical Efficiency of Visual Inspection with Acetic acid

Clinical Benefits

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(Source: Cervical cancer screening and management of cervical pre-cancers, WHO, 2017)

VIA and VILI are suitable for pre-screening tests for cervical cancer. Thanks to the

innovative technology, you can take a VIA-style cervical image continuously using a

smartphone.

Gallay C, Girardet A, Viviano M, et al. Cervical cancer screening in low-resource settings: a smartphone

image application as an alternative to colposcopy. Int J Womens Health. 2017;9:455‐461. Published2017 Jun 22. doi:10.2147/IJWH.S136351

VIA can be used alone or in combination with a cell test for screening tests forcervical cancer, and can also replace a cytoscopy if the medical environment ispoor.

DOI: 10.1200/JGO.17.00127 Journal of Global Oncology - published online February 28, 2018

The accuracy of the VIA is comparable to that of a cell test, and can replace the

cytoscopy.

Omole-Ohonsi A, Aiyedun T A, Umoru J U. Diagnostic accuracy of VIA compared to Pap smear cytologyin detecting premalignant lesions of the cervix. Afr J Med Health Sci 2013;12:25-30

VIA is more sensitive than cytoscopy and cell testing has higher specificity than VIA.

Therefore, VIA and cytoscopy are useful for complementary uses.

Basu, et al.(2003). Visual inspection with acetic acid and cytology in the early

detection of cervical neoplasia in Kolkata, India. International journal of gynecological cancer

: official journal of the International Gynecological Cancer Society. 13. 626-32. 10.1046/j.1525-1438.2003.13394.x.

Product name

Appearance

Cerviray

Korea

Portable / Optical / Digital

Auto + Manual

3X ~ 5X Optical

Battery driven

LED (anti-glare function)

Yes

Yes

Yes

Mobile ODT_EVA

Israel

Portable / Optical

Manual

4X optical

Battery driven

LED

Yes

No

No

Kejian-AD

China

Portable / Digital

Manual

Digital zoom to 12x

Battery driven

LED

Yes

No

No

MedGyn

U.S.

Portable / Digital

Manual

Digital zoom to 36x

Battery driven

LED

Yes

No

No

Leisegang Optik 2

Germany

Portable / Optical / Digital

Manual

3.75x, 7.5x, 15x

Cable power

LED

Yes

No

No

Country

Type

Focus

Opticalmagnification

Energy source

Lightsource

Greenfilter

Remotediagnosis

A.I.

References

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APA Waxman, et al. MD12 ASCCP Colposcopy Standards: How Do WePerform Colposcopy? Implications for Establishing Standards, Journal ofLower Genital Tract Disease: October 2017 - Volume 21 - Issue 4 - p 235-241https://journals.lww.com/jlgtd/FullText/2017/10000/ASCCP_Colposcopy_Standards__How_Do_We_Perform.5.aspx

Diagnosis of cervical precancer: Use of colposcopyhttps://obgynkey.com/diagnosis-of-cervical-precancer-use-of-colposcopy/

Gallay C, Girardet A, Viviano M, et al. Cervical cancer screening in lowresourcesettings: a smartphone image application as an alternative tocolposcopy. Int J Womens Health. 2017;9:455‐461. Published 2017 Jun 22.doi:10.2147/IJWH.S136351

Waxman AG, Buenconsejo-Lum LE, Cremer M, et al. Cervical CancerScreening in the United States-Affiliated Pacific Islands: Options andOpportunities. J Low Genit Tract Dis. 2016;20(1):97‐104. doi:10.1097

Sriplung H, et al. Success of a cervical cancer screening program: trends inincidence in songkhla, southern Thailand, 1989-2010, and prediction of futureincidences to 2030. Asian Pac J Cancer Prev. 2014;15(22):10003-8. PubMedPMID: 25520060.

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SOGC/ SCC Clinical Practice Guideline : Colposcopic Management of AbnormalCervical Cancer Screening and Histologyhttp://ifcpc.org/newWP/wp-content/uploads/2017/10/Colposcopy-Guidelines-FINAL-2012-02-19.pdf

Mabeya H, Khozaim K, Liu T, et al. Comparison of conventional cervicalcytology versus visual inspection with acetic acid among humanimmunodeficiency virus-infected women in Western Kenya. J Low Genit TractDis. 2012;16(2):92‐97. doi:10.1097/LGT.0b013e3182320f0c

Walmer DK, Merisier D, Littman E, Rodriguez G, Venero N, Henderson M,Katz D, Edwards R. Portable colposcopy in low-resource settings. J AcquirImmune Defic Syndr. 2004 Oct;37 Suppl 3:S167-70. PubMed PMID: 16419267.

Jeanne S. Mandelblatt, et al. Costs and Benefits of Different Strategies toScreen for Cervical Cancer in Less-Developed Countries, JNCI: Journal of theNational Cancer Institute, Volume 94, Issue 19, 2 October 2002,Pages 1469–1483, https://doi.org/10.1093/jnci/94.19.1469

Basu PS, et al. Visual inspection with acetic acid and cytology in the earlydetection of cervical neoplasia in Kolkata, India. Int J Gynecol Cancer.2003 Sep-Oct;13(5):626-32. PubMed PMID: 14675346.

Shastri SS, Dinshaw K, Amin G, et al. Concurrent evaluation of visual,cytological and HPV testing as screening methods for the earlydetection of cervical neoplasia in Mumbai, India. Bull World Health Organ.2005;83(3):186‐194.

Egede J, Ajah L, Ibekwe P, Agwu U, Nwizu E, Iyare F. Comparison of theAccuracy of Papanicolaou Test Cytology, Visual Inspection WithAcetic Acid, and Visual Inspection With Lugol Iodine in Screening forCervical Neoplasia in Southeast Nigeria. J Glob Oncol. 2018 Sep;4:1-9. doi:10.1200/JGO.17.00127. PubMed PMID: 30241249; PubMed Central PMCID:PMC6223424.

Diagnostic accuracy of VIA compared to Pap smear cytology in detectingpremalignant lesions of the cervixOmole-Ohonsi A, Aiyedun T A, Umoru J U Year : 2013 | Volume: 12 | IssueNumber: 1 | Page: 25-30

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Cerviray AI is used worldwide

to prevent cervical cancer

Contact us

[email protected] | www.aidot.ai