Agrow’s Service Company Guide 2013...Agrow’s Service Company Guide 2013 26 Your research Our support Harlan Laboratories Contract Research Services Pharmaceuticals/Biotech Chemicals

Consultancies & other advisory bodies

Market research companies

Contract research organisations

Diagnostics & other suppliers

Custom manufacturers

Formulation companies & additives suppliers

Intermediate suppliers

Biopesticides

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Agrow’s Service Company Guide 2013

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Your research Our support Harlan Laboratories Contract Research Services

Pharmaceuticals/Biotech

Chemicals

AgroChemicals/Biocides

With a presence across 12 countries, Harlan Laboratories Contract Research Services offers local expertise with international reach. Factor in our scientific excellence and a focus on customer service and you can be assured that we really can help you do research better.

For more information visit www.harlan.com/crs

©2012 Harlan Laboratories, Inc. Harlan, Harlan Laboratories, Helping you do research better, and the Harlan logo are trademarks of Harlan Laboratories, Inc.

www.harlan.com/crs

• Inhalation Toxicology• Higher Tier Analytics• Environmental Science

SERVICE COMPANY GUIDE CONSULTANCIES & OTHER ADVISOR BODIES

©Informa UK Ltd 2013 3

Consultancies & other advisor bodies

APCOffices worldwide including: UK, France, Poland, Australia and Brazil

www.apc.eu.com

Tel: +44 (0) 1937 587 962 Email: [email protected]

APC provides regulatory services to the Agrochemical, Biocide and Chemical industries.

APC’s worldwide team can help you achieve National, European and International registrations and maximise your regulatory product portfolio and associated sales potential. We deliver timely, cost effective solutions in all aspects of the regulatory process.

Our consultancy has 3 main strengths:

• Scientific: Chemists, agronomists, toxicologists & environmental experts.

• Regulatory: Each member of APC’s worldwide team has extensive knowledge and expertise in their market sector and of country specific and regional regulatory requirements.

• Strategic & project managers: APC’s regulatory experts have professional knowledge coupled with business acumen and hands-on experience.

APC provides a complete range of dossier compilation services for active substance approval, product registration / re-registration and active substance renewal (AIR 3) in all EU Member States:

• Preparation and submission of active substance and product dossiers in accordance with EU and national requirements

• Preparation of active substance renewal (AIR 3) supplementary dossiers and updating statements

• Preparation of biological assessment dossiers (BAD)

• Monitoring of regulatory studies and field trials

• Data Gap Analysis (DGA)

• Assessment of registrability of intended uses according to new EU risk assessments

• Literature searches / study summaries

• Data Matching evaluations

• Technical Equivalence submissions

• Project management throughout the evaluation processes

• Co-ordinating multi-company Task Forces

• MRL/Import tolerance applications

APC can also offer a complete service for development and product registrations in many key countries throughout Asia, Australasia, Eastern Europe and South America.

AGRI-NOVA TECHNOLOGY LTD7 Belmont Hill Newport Saffron Walden Essex CB11 3RF UK

Tel: +44 (0)5600 756 944 Fax: +44 (0)5600 756 945

[email protected] [email protected] www.agri-nova.biz

Contact: Clive Newitt

Since 2002, Agri-Nova Technology has offered commercial consultancy services to a range of international companies.

From simple market analysis to new technology appraisals and valuations, we help small and medium sized enterprises find realistic and pragmatic solutions to their commercial questions.

Led by Clive Newitt, Agri-Nova, with many year’s experience in the UK and International crop protection industry, can provide market development support, logistics and administration services, manufacturing solutions as well as full marketing planning and recruitment and co-ordination of EU wide distributor networks.

To learn more about how we can help, please contact Clive Newitt or Dr Richard Milling ([email protected]).

SERVICE COMPANY GUIDE

©Informa UK Ltd 2009 www.agrow.com 1

AMIS GLOBALSuite 4, Vineyard Business Centre Saughland, Pathead Midlothian EH37 5XP UK

Tel/Fax: +44 1225 849178 [email protected] www.phillipsmcdougall.com

Contact: Bob Fairclough

AMIS Global is a joint venture between Phillips McDougall and Kleffmann and is the only company to link global market analysis with original market research data in both crop protection and seeds on a worldwide basis. The AMIS Global database provides data by crop and product sector at the global level, down to brand level sales by volume, value and area treated, by crop and by country. Similar volume, value and area data is presented by variety and crop in the seeds sector.

AMIS Global also operates a consultancy service to assist with market research requirements for particular products or groups of products. The business is integrated with both parent companies providing the broadest base of industry knowledge of any crop protection and seed-based consultancy company.

AMIS GLOBAL Suite 4, Vineyard Business Centre Saughland Pathead Midlothian EH37 5XP UK

Tel/Fax: +44 1225 849178

[email protected]

www.amisglobal.com www.phillipsmcdougall.com

Contact: Bob Fairclough

AMIS Global is a joint venture between Phillips McDougall and Kleffmann and is the only company to link global market analysis with original market research data in both crop protection and seeds on a worldwide basis. The AMIS Global database, based on an unrivalled number of proprietary market research panels, provides data by crop and product sector at the global level, down to brand level sales by volume, value and area treated, by crop and by country. Similar volume, value and area data is presented by variety and crop in the seeds sector. The database also provides a complete breakdown of the sales of all commercially significant active ingredients by crop and country market.

AMIS Global also operates a consultancy service to assist with particular market research requirements for products, modes of action, chemistry classes, crops, pests/diseases/weeds or geographies. The business is integrated with both parent companies providing the broadest base of industry knowledge of any crop protection and seed-based consultancy company.

CONSULTANCIES & OTHER ADVISOR BODIES SERVICE COMPANY GUIDE

4 ©Informa UK Ltd 2013

COMPLIANCE SERVICES INTERNATIONAL (CSI)CSI-Europe Contact: Warren Scott Tel: +44 131 445 6053 [email protected]

CSI-US Contact: Jeremy Wilson Tel: +1 541 516 1277 [email protected]

www.complianceservices.com [email protected]

Since 1988, Compliance Services International (CSI) has been specialising in regulatory and scientific consultation to the crop protection and allied industries. CSI’s services

include agrochemical, biocide, cosmetic and chemical registration (including under TSCA and REACH), hazard assessment (including QSAR and GHS CLP), exposure assessment (including modelling), risk assessment (including for human and veterinary medicines, and relating to endangered species), contract research management, QA consulting, literature searching (including bespoke current awareness services), data compensation evaluations, and M&A regulatory due diligence. Global regulatory strategies are developed for companies wishing to market their products internationally.

AGROW AWARDS Best Supporting Role

Winner 2010, Shortlist 2011, Highly Commended 2012

BLuE FROG SCIENTIFIC LIMITEDRegus House Falcon Drive Cardiff Bay CF10 4RU

Tel: +44 (0) 29 20504020

[email protected]

Contact: Nigel Halsall

Blue Frog Scientific is an independent regulatory consultancy, providing scientific and regulatory affairs solutions to companies in all sectors of the chemical industry. Blue Frog Scientific and Associates offer a full dossier service for registering plant protection products throughout Europe. Our services include, but are not limited to:

Data Gap Analysis

Overview of quality of existing studies and identification of any data gaps for re-submission of dossiers according to EC 1107/2009 and for Annex 1 re-registration of plant protection products. This includes preparation of Application for Approval Renewal documents.

Study Management

Study design and monitoring. Preparation of study summaries.

Dossier Preparation and Regulatory Affairs

Preparation of dRR sections 1 to 7 for registration of plant protection products. Preparation of M-CA and M-CP documents for Annex 1 re-registration of active substances. Communication with regulatory authorities within EU27 to support submissions.

CROPNOSIS LIMITED1 Saint Colme Street Edinburgh EH6 3AA UK

Tel: +44 131 220 8418 Fax: +44 131 464 0317

Email: [email protected]; Web: www.cropnosis.com

Contact: Gautam Sirur

Cropnosis provides incisive analysis to clients in agrochemicals, seeds & agbiotechnology, fine chemicals and investment banking. Analysts’ support is a prime consideration for clients.

Since 1977, Agrochemical Service & Monitor is the foremost reference for tracking and analysing industry performance and trends of leading companies, from country, product and crop perspectives. PhytoPhile covers significant news breaking in the industry.

APD is an essential tool for competitor analysis, with current, past, forecast global sales-volumes, product/crop/pests, manufacturers, brands, launch dates, applications & rates on over 570 actives. Product Analysis helps users generate reports for 500 different queries.

Strategic consulting helps clients achieve a competitive edge globally in areas of competitor analysis, M&A due diligence, market opportunity assessments, product/market evaluation and sales forecasts, company strategic review and partnering opportunities.



DEXTRA INTERNATIONALAv. Corts Catalanes 9-11, 08173 Sant Cugat del Vallés Barcelona Spain

Tel: +34.93.583.95.53

[email protected] www.dextrainternational.com

Contact: Ana Santillana

Dextra International is a leading strategic consultancy firm specialized in the crop protection business at an international level. Our target focuses on our client´s international growth, starting with a deep analysis of the product portfolio and the definition of new potential markets. Dextra strategies are based on detailed market analysis and cost-effective registration processes.

Dextra provides you with country-basis market surveys to take the right decision on registration investments and distribution channels. Our Regulatory consultants advice you on the strategic registration decisions and oversee the whole process, from dossier preparation fulfilling local requirements until registration obtaining.

Dextra has its headquarters in Barcelona (Spain), being the main markets of activity: Europe, USA and Latin American countries.

Dextra International is the Right Key for your Internationalization.

DHD-CONSuLTING GMBHLilly-Reich-Str. 8, D-31137 Hildesheim Germany

+49 5121 91873 0

[email protected]

www.dhd-consulting.de

Contact: Dr. Dorothee Heimann

DHD-Consulting GmbH provides scientific and regulatory services for Agrochemicals, Biopesticides and Biocides according to the relevant Directives and Regulations. Our services comprise data review, consultation on requirements and identification of data gaps, project co-ordination and study-monitoring, environmental fate modeling, ecological and toxicological exposure calculations and expertises (including QSAR and GHS CLP), risk assessments, and Biological Assessment Dossiers. We prepare and submit Dossiers in the required formats (including CADDY and IUCLID) for zonal and national registrations in the EU as well as for (re-) registration on EU level.

DHD-Consulting GmbH stands for quality and timeliness, flexibility and more than 18 years experience.

Logo:

EBRC Consulting Raffaelstrasse 4 30177 Hannover Germany Tel.: +49 511 89 83 89 0 Fax: +49 511 89 83 89 10 [email protected] www.ebrc.de EBRC’s services encompass the full range of regulatory support for plant protection products, biocides and industrial chemicals under REACH. Comprehensive toxicological, ecotoxicological and environmental fate expertise is provided together with data gap analyses and literature searches for compliance with regulatory data requirements. Electronic submissions (IUCLID, CADDY) supplement our scientific support as routine services. Plant protection product registrations according to EU national Member State legislations as well as EU requirements are processed for all EU member states following the zonal concept (dRR) and also the requirements for the EU notification of active substances. Full dossier compilation is performed in agreement with the requirements of the plant protection product directive, the biocides directive and the REACH regulation, including biological dossiers, complex exposure or risk assessments and computer modelling of environmental fate behaviour. Task force management, project coordination and scientific monitoring of experimental investigations complete this package of services.

EBRC CONSuLTINGRaffaelstrasse 4, 30177 Hannover Germany

Tel: +49 511 898389 0 Fax: +49 511 898389 10

[email protected] www.ebrc.de

Contact: Torsten Grewe

EBRC’s services encompass the full range of regulatory support for plant protection products, biocides and industrial chemicals under REACH. Comprehensive toxicological, ecotoxicological and environmental fate expertise is provided together with data gap analyses and literature searches for compliance with regulatory data requirements. Electronic submissions (IUCLID, CADDY) supplement our scientific support as routine services. Plant protection product registrations according to EU national Member State legislations as well as EU requirements are processed for all EU member states following the zonal concept (dRR) and also the requirements for the EU notification of active substances. Full dossier compilation is performed in agreement with the requirements of the plant protection product directive, the biocides directive and the REACH regulation, including biological dossiers, complex exposure or risk assessments and computer modelling of environmental fate behaviour. Task force management, project coordination and scientific monitoring of experimental investigations complete this package of services.

ENVIRONWillem Arntszlaan 115 3734 EE Den Dolder The Netherlands

Tel: +31 30 698 62 10 Fax: +31 30 698 62 39

[email protected] www.environcorp.com

Contact: Dr Henk Verhaar

ENVIRON offers highly qualified expertise in human toxicology and ecotoxicology, chemistry and regulatory affairs to support the registration of agrochemicals, biocides and chemical substances (REACH). Services include feasibility studies; dossier preparation; development of registration strategies; statistical analysis; preparation of summaries and evaluation; risk assessments (occupational, dietary and eco); toxicokinetic modelling; formulation of expert statements; EU registrations (review and new substances); outsourcing and market research. ENVIRON stands for flexibility, cost effectiveness, quality and reliability.



JSC INTERNATIONALSimpson House Windsor Court Clarence Drive Harrogate North Yorkshire HG1 2PE UK

Tel: +44 1423 520245 Fax: +44 1423 520297

[email protected] www.jsci.co.uk

Contact: Lucy Croucher

JSC International provides expert independent regulatory and risk assessment services to the agrochemical, biocides and chemical industry. The team of scientists from regulatory, industry and contract research backgrounds has extensive experience in European regulatory affairs. Through its network of collaborators the company has the capability to extend this to global regulatory support.

JSC provides advice on the development of regulatory strategies, data gap analysis, study monitoring, dossier preparation and submission under Council regulation 1107/2009, BPD and REACH (including CADDY and IUCLID5) and has an excellent track record in post-submission support leading to many successful Approvals. JSC can also develop strategies for agrochemical active substance renewals and product authorisations for agrochemicals and biocides.

GAB CONSuLTING GmbHHinter den Höfen 24 21769 Lamstedt Germany

Tel: + 49 4773 8889 0 Fax: + 49 4773 8889 20

Email: [email protected] www.GAB-consult.de

Contact: Dr. Adolf Heintze

GAB Consulting is an independent provider of registration services for agrochemicals, bio-control agents, micro-organisms, biocides, chemicals including nanomaterials, feed additives, and animal pharmaceuticals in Europe and overseas. We service the needs of the industry by providing competent and flexible regulatory and scientific expertise, in compliance with the latest OECD and EU requirements, to ensure your product gets registered. Our full range of services includes dedicated project managers overseeing complete dossier preparation from initiation through submission to final approval, including risk assessments in all

relevant dossier sections and computerised documentation.

Since the establishment our company in 1998, we have developed a reputation for professionalism, adaptability, resourcefulness and, above all, for getting the job done. During this time, our staff has continuously increased and currently comprises of over 50 scientists and documentation assistants, all offering expertise in the development, assessment and registration of new active ingredients as well as in supporting old substances. For national (re-) registrations we prepare core dossiers amended by national addenda for specific Member States requirements.

In addition, our senior specialists ad hoc group (the “fire brigade”) is available to serve you immediately and solve any issues with authorities requests.

EXPONENT INTERNATIONALThe Lenz Hornbeam Business Park Harrogate HG2 8RE UK

Tel: +44 (0)1423 853200

[email protected] www.exponent.com

Contact: Mr Nicholas Pear

Exponent International’s regulatory specialists have extensive European expertise gained with the regulatory agencies, independent consultancies, contract research organisations and industry. Our expertise is in all technical aspects relating to the regulation of plant protection products, biocides and industrial chemicals, including regulatory strategy and project/task force management. We can assist clients with the preparation of dossiers for both EU and national registrations, support discussions on regulatory documents, import tolerance applications, submissions to panels such as JMPR & JMPS, classification and labelling and study monitoring. We are also able to manage all aspects of REACH, including data review, SIEF discussions, generation of CSRs and IUCLID dossiers, as well as manage consortia.



LKC SwITzERLAND LTDHauptstrasse 10 Fullinsdorf 4414 Basel Land Switzerland

Tel: +41 61 906 8500 Fax: +41 61 906 8509

[email protected] www.LKC-ltd.com

Contact: Dr David Kane

LKC offer experience and strategic advice to clients who want to be successful in Europe.

Development and Registrations of Crop Protection Products, Biocides, Veterinary Medicines, Pharmaceuticals and specialized chemicals (REACH) are handled by our scientific experts.

We have technical and regulatory expertise to contract and monitor studies including higher tiered studies; to interpret the findings; to prepare the appropriate risk assessments and compile regulatory dossiers in both paper and electronic formats. We engage in dialogue with Regulatory Authorities and work with a network of global affiliates to provide a ‘big picture’ perspective for our clients.

LKC is a GLP Certified facility for directing multi-site studies to ensure the best scientific database for our clients.

Contact LKC to see how we can find solutions to your regulatory challenges.

PHILLIPS MCDOuGALLSuite 2 Vineyard Business Centre Saughland, Pathhead Midlothian, EH37 5XP Scotland UK

Tel: +44 1875 320611 Fax: +44 1875 320613

[email protected] www.phillipsmcdougall.com www.agreworld.com

Contact: Matthew Phillips

Phillips McDougall offers publications and consultancy across the crop protection, biotechnology and seeds industries. The AgriService provides an authoritative and comprehensive analysis of the global crop protection and agricultural biotechnology industries, incorporating profiles of the leading companies along with crop, chemistry, R&D and country market reviews and forecasts, all supported by basic market research through its alliance with Kleffmann. The AgriService includes a complete product directory and company support service as well as the monthly research note, AgriFutura. The Seed Service provides a similar analysis of the seeds and traits industry.

AgreWorld is a daily web-based information service that provides data and analysis of recent events across all the major agricultural inputs industries, but particularly agrochemicals and seeds.

Phillips McDougall has a respected reputation as a leading industry commentator, regularly quoted in industry and financial publications.

PROTECH CONSuLTINGPO Box 851 Eltham VIC 3095 Australia

Tel: + 61 3 9850 3275 Fax: +61 3 9850 3277

[email protected] www.protechconsulting.com.au

Contact: Rosemary Henderson

Established in 1989, Protech Consulting provides a range of technical services to the crop protection and animal health industries in Australia, New Zealand and Pacific Islands.

In the area of regulatory support, company services include submissions for registration of new agricultural and veterinary products; the updating of labels and applications for label extensions; the preparation of trial and off-label applications along with ongoing regulatory support. Technical support activities include advice on development programmes and registration requirements. At field level, the company advises on the design, evaluation and co-ordination of laboratory and field trials. The company also runs an extensive training programme including Agsafe and Chemical Users courses.

SCC GmbH – SCIENTIFIC CONSuLTING COMPANYAm Grenzgraben 11 55545 Bad Kreuznach Germany

Tel: +49-671-29846-0 Fax: +49-671-29846-100

Email: [email protected] www.scc-gmbh.de

Contact: Dr Friedbert Pistel

Scientific Consulting Company (SCC) is one of Europe’s largest, independent, consulting companies specialising in the registration of plant protection products, biocides, chemicals and consumer products, and feed and food additives. Our staff of experienced scientific experts can help with all aspects of agrochemical and biopesticide registration. Other areas of competency include the establishment of efficacy programs, task force/consortia management, GLP archiving and CADDY dossier preparation. The Integrated Pest Management group is concerned with biopesticide and biostimulant related issues, dealing with new scientific and regulatory developments and interactions of European regulatory frameworks, such as the sustainable use of plant protection products, the use of biostimulants pursuant to fertilizer law, or the implementation of organic farming principles.



XENEX ASSOCIATESThe Granary (unit 5) Shiprods farm Bashurst Hill Itchingfeild West Sussex RH13 0PD

Tel: +44 1403 791593 Skype rob.fryatt

[email protected] www.xenexassociates.com

Contact: Rob Fryatt

Shortlisted for ‘Best supporting Role’ in the 2010 and ‘Best Innovation in Non-Crop’ in the 2011 Agrow Awards, Xenex are the leading international business consultants to markets Beyond-Agriculture and within Agriculture worldwide. Through its extensive team of specialist Associates it is able to assist companies of any size with strategic market targeting and business development within the complex markets of Consumer Pest control, Mosquito Abetment, Turf and Ornamentals, Food Legislation and Bio-Control.

Xenex is able to offer up to date market intelligence and a unique insight into major territories and market sectors worldwide, especially in China.

We specialise in helping crop protection companies make the move from Agriculture to markets Beyond-Agriculture. If you are considering these markets we are the first and only contact you need to make.

TSGE LLPConcordia House St James Business Park Grimbald Crag Court Knaresborough North Yorkshire HG5 8QB UK

Tel: +44 (0) 1423 799633 Fax: +44 (0) 1423 797804

[email protected] www.TSGEurope.com

Contact: Alison Hamer

TSGE DEuTSCHLANDRichthofenstrasse 29 31137 Hildesheim Germany

Tel: +49 (0) 5121 708580 Fax: +49 (0) 5121 708589

[email protected] www.TSGEDeutschland.com

Contact: Hermann Wilhelmy

TSGE IBERIAAvenida de Galicia, 22, 5º Dcha 33005 Oviedo Asturias, Spain

Tel: +34 984 180 643 Fax: +34 984 180 634

[email protected] www.TSGEIberia.com

Contact: Maria Fernández

TSGE SLOVENIAŠpruha 19 1236 Trzin Slovenia

Tel: +386 1 729 7183 Fax: +386 1 729 7184

[email protected] www.TSGESlovenia.com

Contact: Bojana Zgonec

TSGE POLANDOddział w Polsce ul. Puławska 405 a 02-801 Warszawa Poland

Tel: +48 (0) 22 468 8121

[email protected] www.TSGEPoland.com

Contact: Aleksandra Gniado

A leading European regulatory consulting company, TSGE’s scientific, regulatory and registration specialists are actively engaged in obtaining and defending product registrations across Europe.

With offices located in the UK, Germany, Spain, Slovenia and Poland, our specialists can prepare active substance and product dossiers including lower to higher tier risk assessments in the areas of plant protection, biocides, animal health, REACH, cosmetics, food contact and consumer products. TSGE also successfully participates in and manages task forces and consortia.

EuROPEAN GROuP OF COMPANIES TSG NORTH AMERICA

wASHINGTON DC OFFICE1150 18th Street, NW Suite 1000 Washington DC, 20036

CALIFORNIA OFFICE 712 Fifth Street Suite A Davis, CA 95616

Tel: +1 530 757 1245 Fax: +1 530 757 1299

www.TSGUSA.com

CANADIAN OFFICE7110 Cobble Hills Rd. R. #4 St Marys, ON N4X 1C7

www.TSGCanada.ca

Contact: Barb Yates [email protected]

Tel: +1 519 349 2985 Fax: +1 519 349 2986

TSG provides state, federal and international expertise on a wide range of scientific and regulatory issues. With experts in regulatory affairs, chemistry, toxicology, ecotoxicology, residue and metabolism, environmental fate, efficacy and risk assessment, TSG provides services in support of the registration, compliance and defence of chemically related products. Our clients include chemical, pesticide, fertilizer, consumer product, food, personal care and animal health companies, as well as industry groups, trade associations and law firms.

SERVICE COMPANY GUIDE MARKET RESEARCH


DEXTRA INTERNATIONALAv. Corts Catalanes 9-11, 08173 Sant Cugat del Vallés Barcelona Spain

Tel: +34.93.583.95.53

[email protected] www.dextrainternational.com

Contact: Ana Santillana

Dextra International is a leading strategic consultancy firm specialized in the crop protection business at an international level. Our target focuses on our client´s international growth, starting with a deep analysis of the product portfolio and the definition of new potential markets. Dextra strategies are based on detailed market analysis and cost-effective registration processes.

Dextra provides you with country-basis market surveys to take the right decision on registration investments and distribution channels. Our Regulatory consultants advice you on the strategic registration decisions and oversee the whole process, from dossier preparation fulfilling local requirements until registration obtaining.

Dextra has its headquarters in Barcelona (Spain), being the main markets of activity: Europe, USA and Latin American countries.

Dextra International is the Right Key for your Internationalization.

GfK KYNETEC Weston Court Weston Newbury Berkshire RG20 8JE UK

Tel: +44 1488 649135 Fax: +44 1488 649131

[email protected]; www.gfk.com

Contact: Antony Goulds MCIM

GfK’s Animal and Crop Health is the leading global, full-service, full-spectrum provider of market research and consulting services to the animal health, crop protection, seed, biotechnology, and farm machinery industries. With offices across the Americas, Europe, Asia and Australasia, GfK provides a broad range of market intelligence and actionable insights. Our extensive experience includes longstanding relationships with global companies in the agricultural supply industry. As part of the GfK global network, we can provide additional advanced market tools, with the benefits of leveraging outside perspectives from other industries and of having access to over 12,000 professionals operating in over 100 countries.

KLEFFMANN GROuPMühlenstr. 1 59348 Lüdinghausen Germany

Tel: +49 2591 9188 0 Fax: +49 2591 9188 900

[email protected] www.kleffmann.com

Contact: Burkhard Kleffmann

Kleffmann Group is the leading provider of agricultural market research services and offers via its amis® panel surveys worldwide farmer based information for all major crops - covering seeds and crop protection inputs.

Alongside its amis® panel information, the full-service-company provides a broad portfolio of innovative and customised ad hoc research solutions to gather impartial data about the latest developments on agricultural markets including the fertiliser, animal health and machinery sector.

With 17 offices located in Latin America, Europe, Asia as well as Australia and a network of selected partner companies such as Phillips McDougall and IBR Ltd, Kleffmann Group operates in more than 70 countries across the globe.

SPECIALTY PRODuCTS CONSuLTANTS, LLC35 East Main Street Mendham NJ 07945 US

Tel: +1 973 543 5195 Fax: +1 973 543 5196

[email protected]

Contact: Gary D Curl

Founded in 2000, Specialty Products Consultants is the recognized leading provider of market research studies to the specialty (non-crop) pesticide industry. SPC clients include a significant majority of the manufacturers and distributors serving the professional turf and ornamental and structural pest control markets.

SPC sponsors two syndicated studies for each of the two market areas (T&O, Pest Control) annually; SPC’s survey-based studies report end user buying behavior, attitudes, brand awareness, and manufacturer level product sales. SPC’s transaction-based studies, in partnership with XS, Inc., track in-season sales and market share performance and invoiced pricing data for all chemical products. Both studies are delivered to clients via easy to use and secure web interfaces.

For more information please visit SPCresearch.com and SPCexpress.com

Market research

CROs SERVICE COMPANY GUIDE

Contract research organisations


AGRISEARCH SERVICES50 Leewood Drive Orange NSW 2800 Australia

Tel: +61 2 6362 4539 Fax: +61 2 6362 7844

[email protected] www.agrisearch.com.au

Contact: Martin Collett

Agrisearch Services is Australasia’s largest independent contract agricultural and biological research organisation. Established in 1970, the company has experienced staff, combined with extensive field and laboratory facilities at 15 locations in Australia and New Zealand. Core activities include efficacy, safety and residue studies in plants and animals, crop and variety testing including GMOs, off-season testing, pesticide analysis and regulatory affairs consulting. The company is the only CRO in the Asia/Pacific region that is able to offer GLP-compliant work for both the field and analytical phases of crop and animal residue studies.

AGROCHEMEXAldhams Farm Research Station, Lawford, Manningtree, Essex, CO11 2NF

+44 1206 281703, +44 1206 281750

[email protected], www.agrochemex.com

Contact: Alan Gamblin

AgroChemex, unique in Europe, offers a range of GLP/ORETO-accredited R&D facilities at its extensive modern research station. They specialise in e-fate and behaviour; plant metabolism; field studies (arable, horticultural, top fruit and vines); and glass house studies in fully computerised greenhouses.

AgroChemex International offers worldwide study management of worker exposure, residue and soil dissipation studies. With its team of top class scientists the company aims to provide an efficiently flexible and friendly service.

AgroChemex Environmental, new for 2012 has the capability to undertake aquatic and terrestrial ecotoxicology testing on a variety of species to meet OECD requirements. In addition they bring analytical capability to the site enabling them to offer a complete package of services.

AGROLAB A/SRøjleskovvej 18, DK-5500 Middelfart, Denmark

+45 64 40 65 75

[email protected] www.agrolab.dk

Contact: Martin Gejl

Agrolab is the leading CRO in the EU-North zone, with field trial stations in Denmark, Sweden and Latvia covering the climatic variance of the zone.

Agrolab provides clients with an independent and confidential service of the highest quality.

Agrolab has been GLP-certified since 1989, GEP-certified since 1996 and GMO-certified (AI) since 2008.

Registration support

The Agrolab registration team specialises in thorough knowledge of the EU-North zone and the directive 91/414 EEC and the regulation EC 1107/2009. Agrolab is a highly qualified sparring partner for planning the registration of your PPPs in EU. We are specialists in ground and surface water modelling and environmental risk assessment. We prepare all parts of the Annex III for application.

AGROBLu HELLAS LTD 20th km Thessaloniki-Polygiros PO Box 888 Nea Redestos Greece 57001 Thessaloniki

www.agroblu.com

Tel: +30 2310 466455

Email: [email protected]

Contact: Dr Stefano Cassani - Managing Director

Agroblu Hellas Ltd is a GLP/GEP greek certified facility that has been coordinating Mediterranean projects of Regulatory, Good Laboratory Practice Studies, including MAGNITUDE OF RESIDUES and ENVIRONMENTAL FATE besides accurate GEP EFFICACY and SELECTIVITY studies.

All studies have been conducted in a wide range of mediteranean crops using herbicides, fungicides, insecticides, acaricides and nematicides following the EPPO test Guidelines. REGULATORY CONSULTANCY is an additional service provided by Agroblu Hellas Ltd.

SERVICE COMPANY GUIDE CROs


ANADIAG16 rue Ampere F-67500 Haguenau France

Tel: +33 3 90 59 00 00 Fax: +33 3 88 93 41 50

[email protected] www.anadiag.fr

ANADIAG is one of the major CROs in Europe and provides a wide range of services for the registration of agrochemicals.

Field Experimentation ServicesThe company owns one of the largest European field GEP and GLP certified networks in France, Germany, Belgium, The Netherlands, Poland, Czech Republic, Hungary, Bulgaria, Greece, Italy, Spain and Portugal – which provides GLP, GEP development, registration and marketing trials. We also have partner companies in other territories to ensure complete coverage if required.

All studies are performed in compliance with the

international guidelines for GLP or EPPO guidelines.

Laboratory servicesANADIAG has its own GLP facilities to manage complex studies in analytical chemistry, physical measurements, environmental fate and residue analysis.

Regulatory AffairsANADIAG manages a regulatory group with excellent connections at EU and National level and can manage the preparation and submission of your EU Annex II and Annex III dossiers as well as National applications.

The combined knowledge our agronomists team, plus staff holding chemistry and biology doctorates combined with a high-level quality assurance unit, ensures great synergy, high-quality work and provides technical support and services for marketing and strategy of plant protection product in EU.

AGROBLuVia San Bernardo 35 20017 Rho Milano Italy

www.agroblu.com

Tel: +39 02 93506336


Contact: Dr Stefano Cassani - Technical Director

Operating since 1993 in Italy in connection with Laboratories in all the Mediterranean, Agroblu GLP/GEP certified facility has been coordinating and conducting European projects of Regulatory, Good Laboratory Practice Studies, including MAGNITUDE OF RESIDUES, ENVIRONMENTAL FATE and OPERATOR EXPOSURE and accurate GEP EFFICACY and SELECTIVITY studies.

All studies have been conducted in a wide range of mediteranean crops using herbicides, fungicides, insecticides, acaricides and nematicides following the EPPO test Guidelines.

Agroblu also provides a registration support service and is in regular contact with the Regulatory Authority.

AGROBLU has established and developed e new research Laboratory of Entomology Applied which conducts reseraches and studies on biocides and biological pest control and, moreover, produces insects for Bio-tests. The Laboratory is managed by Prof. Luciano Suss, already Director of the Institutre of Entomology of the University of Milan. The Laboratory is located in ROZZANO (Milan) where the laboratories of the Association Granaria are also located.

Eurofins AgroscienceServices Group

Eurofins AgroscienceServices SAS (Argentina)Tel: +551 93875 [email protected]

Eurofins Agroscience Services Austria GmbH (Austria)Tel: +433 1122 [email protected]

Eurofins do BrasilAgroscience Services (Brazil)Tel: +551 93875 [email protected]

Eurofins AgroscienceServices EOOD (Bulgaria)Tel: +359 6941 [email protected]

Eurofins AgroscienceServices ApS (Denmark)Tel: +456 1140 [email protected]

Eurofins AgroscienceServices SAS (France)Tel: +335 6331 [email protected]

Eurofins AgroscienceServices Chem SAS (France)Tel: +334 6673 [email protected]

Eurofins Agroscience Services Chem GmbH (Hamburg, Germany)Tel: +494 0881 [email protected]

Eurofins Agroscience ServicesEcoChem GmbH (Niefern, Germany)Tel: +497 2339 [email protected]

Eurofins Agroscience Services GmbH (Stade, Germany)Tel: +494 1418 [email protected]

Eurofins AgroscienceServices Kft (Hungary)Tel: +362 2501 [email protected]

Eurofins AgroscienceServices Srl. (Italy)Tel: +390 5166 [email protected]

Eurofins AgroscienceServices sp. z.o.o. (Poland)Tel: +486 1292 [email protected]

Eurofins AgroscienceServices S.L. (Portugal)Tel: +3512 5165 [email protected]

Eurofins AgroscienceServices Srl. (Romania)Tel: +402 5628 [email protected]

Eurofins AgroscienceServices S.L. (Spain)Tel: +349 5418 [email protected]

Eurofins AgroscienceServices Ltd (Thailand)Tel: +662 716 [email protected]

Eurofins AgroscienceServices Ltd (UK)Tel: +441 33286 [email protected]

Eurofins AgroscienceServices Inc. (USA)Tel: +147 8994 [email protected]

Eurofins Regulatory AG(Switzerland)Tel: +146 1836 [email protected]

MITOX Consultants(The Netherlands)Tel: +316 5155 [email protected]

MITOX BV(The Netherlands)Tel: +312 0751 [email protected]

MITOX Field OperationsSouthern Europe (France)Tel: +335 6229 [email protected]

Eurofins Agroscience Services are a global service provider of field, laboratory and regulatory programs. With proven expertise in managing global field studies, worker exposure studies, ecotoxicology, analytical services, physico-chemical property testing, 14C / environmental fate laboratory and field studies, the service offering is continuously developed by knowledge transfer initiatives between the Group’s various centres of expertise across the globe. By acquiring a carefully selected range of CRO’s, Eurofins Agroscience Services has created a unique portfolio of expertise that provides support to plant breeders, agrochemical, biopesticide, biocide and fine chemical manufacturers that spans over 25 years.

www.eurofins.com/agroscienceservices



Eurofins AgroscienceServices Group

Eurofins AgroscienceServices SAS (Argentina)Tel: +551 93875 [email protected]

Eurofins Agroscience Services Austria GmbH (Austria)Tel: +433 1122 [email protected]

Eurofins do BrasilAgroscience Services (Brazil)Tel: +551 93875 [email protected]

Eurofins AgroscienceServices EOOD (Bulgaria)Tel: +359 6941 [email protected]

Eurofins AgroscienceServices ApS (Denmark)Tel: +456 1140 [email protected]

Eurofins AgroscienceServices SAS (France)Tel: +335 6331 [email protected]

Eurofins AgroscienceServices Chem SAS (France)Tel: +334 6673 [email protected]

Eurofins Agroscience Services Chem GmbH (Hamburg, Germany)Tel: +494 0881 [email protected]

Eurofins Agroscience ServicesEcoChem GmbH (Niefern, Germany)Tel: +497 2339 [email protected]

Eurofins Agroscience Services GmbH (Stade, Germany)Tel: +494 1418 [email protected]

Eurofins AgroscienceServices Kft (Hungary)Tel: +362 2501 [email protected]

Eurofins AgroscienceServices Srl. (Italy)Tel: +390 5166 [email protected]

Eurofins AgroscienceServices sp. z.o.o. (Poland)Tel: +486 1292 [email protected]

Eurofins AgroscienceServices S.L. (Portugal)Tel: +3512 5165 [email protected]

Eurofins AgroscienceServices Srl. (Romania)Tel: +402 5628 [email protected]

Eurofins AgroscienceServices S.L. (Spain)Tel: +349 5418 [email protected]

Eurofins AgroscienceServices Ltd (Thailand)Tel: +662 716 [email protected]

Eurofins AgroscienceServices Ltd (UK)Tel: +441 33286 [email protected]

Eurofins AgroscienceServices Inc. (USA)Tel: +147 8994 [email protected]

Eurofins Regulatory AG(Switzerland)Tel: +146 1836 [email protected]

MITOX Consultants(The Netherlands)Tel: +316 5155 [email protected]

MITOX BV(The Netherlands)Tel: +312 0751 [email protected]

MITOX Field OperationsSouthern Europe (France)Tel: +335 6229 [email protected]

Eurofins Agroscience Services are a global service provider of field, laboratory and regulatory programs. With proven expertise in managing global field studies, worker exposure studies, ecotoxicology, analytical services, physico-chemical property testing, 14C / environmental fate laboratory and field studies, the service offering is continuously developed by knowledge transfer initiatives between the Group’s various centres of expertise across the globe. By acquiring a carefully selected range of CRO’s, Eurofins Agroscience Services has created a unique portfolio of expertise that provides support to plant breeders, agrochemical, biopesticide, biocide and fine chemical manufacturers that spans over 25 years.

www.eurofins.com/agroscienceservices

BIOTEK AGRICuLTuRERoute de Viélaines 10120 Saint-Pouange France

Tel: +33 3 25 41 78 78 Fax: +33 3 25 41 78 79

[email protected] www.biotek-agriculture.fr

Contact: Gonzague Derly or John Waples

Biotek Agriculture is one of the few companies who can truly provide global planning, management and implementation of field trials. Field stations and offices are located in the Americas, Europe and Asia. The company has collected over 30 years of experience and is able to mobilize one of the most extensive and capable teams in Pesticide and Seed development.

The headquarters is based in France with additional country bases throughout Europe including: Spain, Poland, England, Italy, Hungary, Germany, Romania and Ukraine. In the Americas we have offices and field stations located in USA, Costa Rica, Brazil and Argentina. Our office in Beijing manages studies in India, Thailand, Japan and of course throughout China. Our GEP services are certified to cover all major crops, pests and diseases. Our GLP services offer residue studies, dissipation studies, import tolerance, and processing studies in our GLP laboratories.

We offer the same procedures throughout the subsidiaries, audited by our own independent quality assurance, to the highest global standards expected by our customers. In addition we offer a personal registration service with particular experience of registration in East Europe.

Our business continues to grow and we will continue to expand our network throughout the Americas, Europe and Asia/ Pacific regions. We would be pleased to support your development and registration for local or global projects.

BIOCHEM AGRAR GmbHTel: 0049(0)3429286325

Email: [email protected] www.biochemagrar.de/ Contact: Gernot Renner

As an independent and GLP compliant CRO we offer expertise and capabilities to conduct studies for product registration of agrochemicals and chemicals. Our services include a broad range of regulatory testing on laboratory, semi-field and field scale at different sites in Germany and Europe.

We provide you with studies necessary for registration including but not limited to Ecotoxicology (Aquatic organisms, Non-target arthropods, Honey Bees, Soil organisms, SMO, Non-target terrestrial plants testing), Field trials (residues, crop rotation, soil dissipation/ accumulation, variety evaluation, efficacy, fertiliser, GMO, demonstration trials) and Analytical chemistry.

BIOTECNOLOGIE B.T. SRLFrazione Pantalla 06059 Todi Perugia Italy

Tel: +39 075 8950045 Fax: +39 075 888776

[email protected] www.biotecnologiebt.it

Contact: Alessia Aguzzi (Business Development Manager)

BIOTECNOLOGIE B.T. S.r.l. (BT) is a CRO offering research services for the registration of Plant Protection Products (chemical and biological), Veterinary Medicines, Biocides, Biopesticides and Pharmaceuticals.

The two sites of BT, Biospheres (Northern Italy) and Biotecnologie BT (Central Italy), cover a total of 3000 m2 including laboratories, greenhouses and an insectarium, the latter being one of the largest in Europe.

Both facilities dispose of cutting-edge equipment and have highly qualified staff with academic degrees in the relevant scientific disciplines. The company holds certificates for GLP and GEP compliance and all research activities are performed in accordance with international Guidelines (OECD, IOBC/WPRS, ESCORT, CIPAC, ICH etc.).


FIELD RESEARCH SuPPORTPotts Kamp 8 D–31515 Wunstorf Germany

Tel: +49 5031 5166999

[email protected] www.field-research-support.de

Contact: Helmut Zöllner

Field Research Support (FRS) was founded in 1997 as a local operator for Europe-wide multi-site studies for agricultural field trials. Since then, FRS obtained GEP recognition in 1997, as well as GLP certification in 2000. The company now offers GLP and GEP field studies in southern, middle and eastern Europe under GLP and GEP recognition by the national authorities. Field studies are conducted by the company’s experts in all main arable crops and a wide range of vegetables, fruits, vines, ornamentals and industrial crops in open field or greenhouses. From 2005 onwards, Field Research Support began a registration and dossier preparation service.

CEMAS (CEM ANALYTICAL SERVICES)www.cemas.co.uk

+44 (0)1344 887100

[email protected]

Contact: Dr Alan Jutsum

CEMAS is a GLP- and GEP-compliant contract research organisation established in 1989 that specialises in residue analysis (including independent laboratory validations and method development), animal transfer studies, 5-batch analysis, agrochemical product analysis, formulation development, ecotoxicology, efficacy studies, soil characterisation, REACh work and pharmaceutical analysis (GMP- and GCP-compliant). Experience in agrochemical research in the company is extensive and includes field residues, dissipation studies, analytical sciences, environmental sciences, product chemistry, formulation work, operator exposure, re-entry studies, and the generation of regulatory dossiers. Experienced personnel and access to state-of-the-art equipment allow CEMAS to generate high quality data on time for all of our clients.

ENTOMOLOGY APPLIED Via Isonzo 20 - 20089 Rozzano Milan Italy

Tel: +39 02 935.06.336 Fax: +39 02 935.06.333


ENTOMOLOGY APPLIED is a large research laboratory highly qualified reference for Entomology and Nematology applied to the fields of Agriculture, Agro-industry, Food and Chemical Industries. ENTOMOLOGIA APPLICATA belongs to the International Group of AGROBLU that is GLP and GEP certified since 1997. The Laboratory offers, within a large range of services, also:

• Deep identification classification of Insects / Arthropods;

• Laboratory and field studies for the determination of the efficacy of Insecticides and Nematicides;

• Evaluation of efficacy of biocides by laboratory studies;

• Determination of effects on non target arthropods and Beneficials;

• Determination of Resistance of target insects to Biocides and Insecticides and Nematicides;

• Biological Activity Dossier for the Registration of Biocides and Crop Protection Products;

• Entomology applied to protection system in Urban areas and Food Quality Control;

Moreover, ENTOMOLOGIA APPLICATA, in a separate facility located in Central Italy (Terracina) produces:

- Insects destined to the inoculation of infestations in field studies;

- Bio-test units called ENTOMONITOR® for monitoring the efficacy of physical or chemical treatments in Food Industries and Stores;

- Insect destined to Biological Protection of Crops and/or IPM.




NIABHuntingdon Road Cambridge CB3 0LE

Tel: +44 1223 342251 Fax: +44 1223 277602

[email protected] www.niab.com

Contact: Jane Thomas

NIAB is a major international centre for plant science, crop evaluation and agronomy, with headquarters in Cambridge and regional offices across the country. NIAB spans the crop development pipeline, combining within a single resource the specialist knowledge, skills and facilities required to support the improvement of agricultural and horticultural crop varieties, to evaluate their performance and quality, and to ensure these advances are transferred into on-farm practice through efficient agronomy.

With an internationally recognised reputation for independence, innovation and integrity, NIAB is ideally placed to meet the industry’s current and future research, information and knowledge transfer needs. We provide a wide range of scientific and technical services including seed quality tests, food authenticity and traceability, pathogen diagnostics and agrochemical efficacy evaluation.

Joining with The Arable Group in 2009, as NIAB TAG we conduct field crops research and provide impartial variety and crop husbandry information. The organisation includes The Silsoe Spray Applications Unit, providing unique skills in spray technologies and precision farming. We offer customers an integrated service in delivering quality and reliability through ISO 9001-2000 and GEP management standards.

MAMBO-TOX2 Venture Road The University Science Park Southampton SO16 7NP UK

Tel: +44 (0)23 8076 2580

[email protected] www.mambo-tox.co.uk

Contact: Mike Mead-Briggs

With nearly 30 years’ experience in ecotoxicological research, Mambo-Tox is an independent, GLP-compliant, contract research organisation specialising in terrestrial ecotoxicological studies.

We evaluate the effects of pesticides and biocides on non-target arthropods, soil invertebrates and honeybees. Bioassays following the relevant international testing guidelines are carried out under laboratory, extended laboratory or semi-field conditions, utilising our extensive controlled-environment and glasshouse facilities. We have also carried out many full-scale field trials to assess the impact of pesticides on NTA populations in both arable and orchard crops.

Mambo-Tox understands the importance of delivering quality studies to tight deadlines and can normally offer a rapid turnaround for urgent projects.

MYLNEFIELD RESEARCH SERVICES LTDJames Hutton Institute Errol Road Invergowrie DD2 5DA Scotland

Tel: 01382 568568 Fax: 01382 568501

www.mrsltd.com [email protected]

Mylnefield Research Services Ltd (MRS) is the commercial affiliate of the world leading James Hutton Institute. We are committed to developing sustainable agriculture through advanced marker assisted plant breeding, diagnostics, pathogen testing, fertilizer optimisation and crop nutrition trials. We are officially recognised by the UK Chemicals Regulation Directorate for crop protection efficacy trials, we have access to the latest research into alternative disease and pest control strategies. MRS also offer a wide range of analytical services, including specialist lipid analysis and stable isotope profiling, to an international portfolio of clients in the food and drink, nutraceutical, agbiotech and oil seed industries.

HARLAN LABORATORIES LIMITEDShardlow Business Park London Road Shardlow Derby DE72 2GD UK

Tel: +44 1332 216778

[email protected] www.harlan.com

Contact: Andrew Hill

Harlan Laboratories is a global leader of essential, non-clinical contract research, research models, animal diets and testing services to the agrochemical, biocide, chemical, animal health, pharmaceutical, biotech and medical device industries, further academic and government research organisations.

Harlan understands the importance of combining effective customer service and strong client relationships, with the need for scientific excellence. Stability, reliability, consistency and quality are all essential.

Our core capabilities include:

• Mammalian toxicology, genetic toxicology , in vitro alternative testing

• Ecotoxicology – acquatic, terrestrial ,biodegradation

• Animal and plant metabolism

• Environmental fate and modelling

• Analytical chemistry

• Regulatory affairs – consulting and chemical, biocide and agrochemical registration.



PROMO-VERTRue d’Aste Béon, BP 27 F- 64121 Serres Castet FRANCE

Tel: +33 559 33 77 70 Fax:+33 559 33 12 17

[email protected] www.promovert.com

Contact: Gilles Moulonguet

PROMO-VERT always on the move and offers you the best for your European projects :

• EU Project management

• Agrochemical efficacy field trials

• Plant and soil GLP residue studies

• Full registration dossiers (dRRs and BAD ) according to Regulation 1107/2009.

PROMO-VERT CROP SERVICESPolígono Industral La Choza Calle nuevas tecnologías, n°16 E-41805 Benacazon Sevilla SPAIN

Tel: +34 995 70 99 09 Fax:+34 995 70 99 64

[email protected]

www.promovert.es

Contact: Emilio Fernandez

Regional offices in the major agricultural regions in Spain providing:

• Efficacy work for agrochemical testing under GEP

• Ecotoxicological tests in laboratory and in the field with beneficials

• GLP residue studies for field and processing facilities: olive oil, taint tests.

• Nematode analysis

Let us grow further together

PROMO-VERT CROP SERVICES PORTuGALZona Industrial da Gandra Mazedo 4950-297 Mazedo Monçao PORTUGAL

Tel: +34 995 70 99 09 Fax:+34 995 70 99 64

[email protected]

Contact: Emilio Fernandez

START UP of our office in PORTUGAL

• GEP field trials with agrochemicals for efficacy testing

• GLP residue studies

GEP and GLP certificates granted in 2012 by official Portuguese authorities.

PROMO-VERT HuNGARIA KFTTél: +33 559 33 77 70

[email protected]

Contact: Gilles MOULONGUET

PROMOVERT HUNGARIA Kft at your disposal

• field studies according to local GEP accreditation

• consultancy services for registration

The GEP certificate allows PROMOVERT to offer a full service for efficacy testing with a national network of testing facilities.

Let us grow further together !

PERACTO16 Hillcrest Road Devonport Tasmania 7310 Australia

Tel: +61 3 6423 2044

[email protected] www.peracto.com

Contact: Ian Macleod

Operating since 1976, Peracto is the leading Australasian agricultural contract research organisation with a growing international client base. We provide superior design and conduct of GLP and efficacy studies in all crops grown in Australia and New Zealand. Experienced and fully qualified staff bring a wealth of national and international experience with the company offering out-of-season opportunities for northern hemisphere clients. Peracto delivers a range of independent research, development and technical services including management of chemical residue studies, with capability in soil dissipation, beneficial insect, insect residue and operator exposure studies. For more information visit www.peracto.com

OXFORD AGRICuLTuRAL TRIALSWest Farm Barns Stratton Audley Bicester Oxfordshire OX27 9AS UK

Tel: +44 1869 278172

[email protected] www.oxagtrials.co.uk

Contact: Jon Burgess

Since 1984, Oxford Agricultural Trials (OAT) has been a leading contract research organisation specialising in agrochemical field trials: residue (crop residue and rotation, soil dissipation and accumulation) efficacy, crop safety, variety evaluation, fertiliser and demonstration. The main base in Oxfordshire is equipped with glasshouses and a cold store, whilst regional bases in Devon, Hampshire, Essex, Cambridge, Lincolnshire, Nottinghamshire, Warwickshire, Yorkshire and Scotland ensure products are tested under a variety of environmental conditions. There is close co-operation with research organisations in Europe for many projects.

The company has an excellent reputation for providing a service which is independent, confidential and of the highest quality. Residue trials are conducted in accordance with Good Laboratory Practice (GLP) guidelines and OAT has been an “Officially Recognised Efficacy Testing Facility” (ORETO certificated) since 1998.



SMITHERS VISCIENT Massachusetts, USA Harrogate, UK North Carolina, USA Tokyo, Japan

North America Tel: + 1 508 295 2550 Europe Tel: +44 (0) 1423 532 710 Asia Tel: +81 (0) 42 519 1171

[email protected] | www.smithersviscient.com

Contact: Hope Aubin

Smithers Viscient is a global Contract Research Organization (CRO) providing environmental testing and regulatory services for the crop protection, pharmaceutical, industrial chemical, and the consumer and household product industries. With laboratories located in North America and Europe, Smithers Viscient has performed standard guideline and higher-tiered environmental studies for over 40 years. We conduct studies to satisfy all regulatory requirements globally. Smithers Viscient is a global leader delivering trusted testing services. Offerings include aquatic and terrestrial ecotoxicology, avian toxicology, environmental fate, metabolism, residue, analytical, and product chemistry, consulting, risk assessment, and endocrine testing, including in vitro toxicology, in vivo toxicology, and in vivo ecotoxicology.

REDEBELRue de Chassart 4 B 6221 Saint-Amand Belgium GPS 50.51517 / 4.50453 Tel +32 71 85 33 92

[email protected] www.redebel.com

Director: Ir Tanguy Dumont de Chassart

Since it was founded 25 years ago, REDEBEL has become a leading company in the EU in the following areas:

1. Regulatory affairs for PPP, Biopesticides, Biocides, Adjuvants, REACH, and CLP

2. Study Direction throughout the EU

3. Study Monitoring for Field Trials

REDEBEL prepares complete dossiers for pesticides, biocides, adjuvants & REACH.

Through its wide EU network of partners, REDEBEL is able to

• Act as global Study Director for Pan-EU GLP Residue programmes

• Act as Study Monitor for Pan-EU Efficacy & Selectivity GEP programmes

• Prepare core draft Registration Reports for all EU zones with all respective addenda

• Prepare core Biological Assessment Dossiers (BAD) with specific national addenda

• Submit national applications in the 27 EU Member States

• Carry out all types of Residue, Efficacy & Selectivity trials in Belgium in accordance with REDEBEL’s high quality standards

• Provide clients with high quality R&D & Demo programmes.

SGS GROuP1 Place des Alpes 1201 Geneva Switzerland

Tel: +41 22 739 91 11 Fax: +41 22 739 98 00

www.sgs.com/SeedAndCrop [email protected]

Contact: Olivier Coppey

SGS Seed & Crop Services provides a global network of field trial stations and laboratories for clients’ product development programmes in Europe, Africa, North America, Latin America and Asia-Pacific.

Our experienced interdisciplinary team of agronomists, biologists, chemists, food technologists and geochemists can conduct field trials and laboratory studies to support the screening, development and registration of agricultural and horticultural chemicals, biopesticides, fertilizers and new plant varieties and seeds (including GMO).

With many years of experience in the field of R&D, analytical chemistry, regulatory affairs / registration services and project management, SGS processes laboratory and field studies within the scope of regulatory testing, such as efficacy, residue, operator, consumer safety, environmental fate and behaviour of pesticides as well as toxicological and eco-toxicological testing. The testing is based on international guidelines, including EPPO, OECD, EPA and SETAC and in compliance with GLP (Good Laboratory Practice) or GEP (Good Efficacy Testing).

SGS is the world’s leading inspection, verification, testing and certification company. SGS is recognised as the global benchmark for quality and integrity. With more than 75’000 employees, SGS operates a network of over 1’500 offices and laboratories around the world.

SYNTECH RESEARCH1617 Arena Drive Davis CA 95618 US

Tel: +1 530 753-8880. (US)

Contacts: David Marsden (Global Account Manager, Efficacy/GEP, Daniel Mourad (Global Account Manager GLP), Eric Ythier (Global Account Manager Ecotoxicology) or Dr Luke Farno – Global Account Manager Seeds

Email: [email protected]; [email protected]; [email protected]; [email protected]

www.syntechresearch.com

SynTech Research delivers competitive advantage to clients by providing R&D and registration services for agrochemicals, biocides and seeds, based on the company’s unparalleled expertise in contract crop production and protection research.

Operating in 28 countries worldwide, we conduct field and laboratory studies for over 100 clients, in bio-efficacy, environmental chemistry and ecotoxicology, in agriculture, horticulture and public health, working to GLP/GEP standards.

SynTech Research uses its field stations, regulatory and study director resources, plus its new Environmental Chemistry and Ecotoxicology laboratories in Kansas, to generate studies and submissions of registration dossiers to EPA, EU, PMRA, South America and national regulatory authorities.


CRO SERVICE COMPANY GUIDE

Vigna Brasil Group - “one stop shop” CRO.

www.vignabrasil.com.br

Contact - Fabio Domingues [email protected]

Full support in regulatory, market strategies and field

management (R&D):

Let’s do business in BRAZIL?

BioPesticides

Adjuvants

Agrochemicals

Fertilizers and Innoculants

Soil Conditioners

Food and Food Additives

PCO and Public Health

Home&Garden and Household

Cosmetics

Lubricants and Additives

(Bio) Remediators

Aquatics

Wood Preservatives

Arte_Anuncio_Vigna_Brasil_2013.indd 1 27/05/13 11:01

STAPHYT23 route de Moeuvres 62860 Inchy-en-Artois France

Tel: +33.3.21.21.45.21

www.staphyt.com

Contacts:

Business Development Manager: Yves Coconnier ([email protected] )

Regulatory Affairs & Consulting Manager: Benoit Delcour ([email protected] )

Eastern & Central EU specialist: Bruno Maurer ([email protected])

Staphyt is the company you can rely on to succeed in your trials, their management and registration issues

These key points show our commitment to provide the best quality within agreed deadlines:

• 25 years experience

• 210 people

• 22 countries covered

• Access to 67 field trial stations in Europe

• Access to all crops

• GEP & GLP accredited

We have the expertise you need to succeed at all stages from screening through to registration.

Staphyt offers the most complete area of expertise:

• GEP trials (efficacy & dose response, crop safety, practical value, rotational, drift studies, …)

• GLP studies (residue, OPEX, soil dissipation and accumulation, DFR…)

• Screening trials in field and glasshouse

• Non chemical / natural PPP screening/testing and consulting

• Sales support and development trials

• Seed variety testing on all crops, including silage & compositional analysis

• Processing laboratory (100 different processes available)

• Ecotox field & tunnel studies for honey/bumble bees

• Research studies (rain fastness…)

• Laboratory for fungi resistance monitoring pre and post registration

Staphyt regulatory & consulting also offers services in the EU, for Chemical, biocontrol products, fertilisers and growth media, and adjuvants):

• Consulting and strategy

• Pan-European registration program

• Building-up complete Annex II & III Dossiers & submission (Study management, write up of dossier’s according to dRR format including Risk Assessments and BADs)

• Mutual recognition, Bis application, Second trade name…

• Direct contact with National Authorities in Europe

• Trial permits


Regulatory AffairsBusiness AdvisorsField Management

VIGNA BRASILRegulatory Affairs, Market Intelligence and Field Management

Avenida Ipiranga, 318, cj 1601 Bloco A - 16º Andar, Republica, Sao Paulo-SP, 01046-010 Brazil

Tel: (+5511) 3124.4455 skype: vignabrasil

Email: [email protected] www.vignabrasil.com.br

Contact: Fabio Domingues

Vigna Brasil is a contract organisation that works as a full services provider in Brazil, including regulatory affairs, field management (R&D), business advisors and market intelligence. We are able to attend companies interested in: Crop Protection, Biopesticides, Adjuvants, Fertilizers, PCO, Public Health, Household, Lubricants, Wood Preservatives, H&G, Aquatics, Food and Food Additives and Cosmetics.

We provide business facilitator services, helping your company to reduce bureaucracy or operational barriers for starting up and maintaining your operations in Brazil.

In 2004, Vigna Brasil was appointed as a leading company in Agrow’s top 30 CROs (Contract Research Organisations) active in the crop protection industry. In 2008 (April issue), Vigna Brasil was again listed as one of the top 15 CROs. We are the unique Latin American company listed in both reports.


TRIALCAMPPol. Ind. Les valletes C/ Artes gráficas 44 Nave 1A 46192 Monserrat (Valencia) Spain

Tel: +34 96 298 61 43 Fax: +34 96 298 81 42

[email protected] www.trialcamp.es

Contact: Luisa Aznar

TrialCamp provides expert service for registration studies of agrochemicals and technical support for product development.

The company conducts efficacy and selectivity studies under GEP on a wide range of pests and crops; laboratory and semi-field studies on non-target arthropods, earthworms and honeybees under GLP; and field studies for determination of residues under GLP. Its extensive insect culturing facilities allow a wide range of pest and beneficial species to be held for study.

TrialCamp is a reliable, competitive and fully accountable company with an enthusiastic and young team in which the quality of the service is the main objective.

VERSuCHSwESEN PFLANzENSCHuTzEhlbeek 2 30938 Burgwedel Germany

Tel: + 49 5139 8393 Fax: + 49 5139 27095

[email protected] www.versuchswesen.com

Contact: Dr. Paul Reh and Kirsten Heitsch

Versuchswesen Pflanzenschutz is an independent and privately-owned company for agricultural field research, with GLP and GEP certification. The firm was founded in 1990 and has since then provided service for the development of agricultural chemistries. We offer the whole project management from planning trials to the preparation of the biological assessment dossier for the Central and South European Registration Zone (zone B and C). We are very experienced in efficacy and selectivity studies as well as in residue, soil dissipation and rotational crop studies. The trials could be carried out in all agricultural and horticultural crops and in orchards, vineyards, ornamentals, forests and non-agricultural land.

For further information, please contact us: [email protected]

wILDLIFE INTERNATIONAL

8598 Commerce Drive Easton MD 21601 US

Tel: +31 575 573848

[email protected] www.wildlifeinternational.com

Contact: Annegaaike Leopold

Wildlife International, a recognized leader in higher-tier Ecotoxicology and Environmental Fate testing for more than 35 years, is part of Evans Analytical Group (EAG) Together with PTRL-West and PTRL-Europe, Wildlife International offers a full suite of environment testing services. We serve and provide support to a global clientele with GLP studies to meet global regulatory requirements for the testing of agrochemicals, industrial chemicals, pharmaceuticals, biocides and animal health products. Our highly experienced and talented team of scientists and technicians focuses on quality, timeliness, innovation and flexibility to meet the complex needs of diverse markets, each of which are confronted with ever more complex regulations.

DIAGNOSTICS & OTHER SUPPLIERS SERVICE COMPANY GUIDE

Diagnostics & other suppliers

HERBISEEDNew Farm Mire Lane West End Twyford RG10 0NJ UK

Tel: +44 118 9349464 Fax: +44 118 9241996

[email protected] www.herbiseed.com

Contact: Steve Morton

For over 20 years Herbiseed has been the leading supplier of weed seeds to the agrochemical and agricultural trials industries. The company’s success is based on stocking an outstanding range of over 600 species of the major weeds of world agriculture, together with providing exemplary worldwide delivery times and friendly, effective customer support.

In addition, Herbiseed supplies seeds of unusual herbs, new crops, wildflowers and species for ecological restoration and agri-environment schemes.



Custom manufacturers

AGRI LIFEC/O SOM Phytopharma (India) Ltd 154 A/5 SVCIE IDA Bollaram 502 325 Medak Dist Hyderabad India

Tel: +91 8458 279905 Fax: +91 8458 279904

www.agrilife.in Email: [email protected] mobile: +91 9885 446278

Contact: Dr Devanur Venkatesh

Manufactures BioPesticides viz. Bt-K, Bt-I, Trichoderma viride, Trichoderma harzianum, Beauveria bassiana, Metarhizium anisopliae, Verticillium lecanii, Azadirachtin, Karanjin – supported by basic data package. Agri Life offers BioFertilizers like Nitrogen Fixing Bacteria, Phosphorous Solubilizing Bacteria, Potash Mobilizing Bacteria, Ferrous Mobilizing Bacteria, Zinc Mobilizing Bacteria, Mn Mobilizing Microbe, Sulfur Mobilizing Bacteria, VAM etc; BioNematicides: Bacillus Firmus and Paecilomys Lilacinus

ANDERMATT BIOCONTROL AGStahlermatten 6 6146 Grossdietwil Switzerland

Tel: +41 62 917 51 25 Fax: +41 62 917 50 06

[email protected] www.biocontrol.ch

Contact: Erich Frank

Andermatt Biocontrol was founded in 1988 by Dr. Martin and Dr. Isabel Andermatt. In the meantime Andermatt Biocontrol is embedded in the family- and employee-owned Andermatt Holding, which has some 100 highly motivated employees.

Key expertise of Andermatt Biocontrol is the development of new products based on baculoviruses and beneficial insects. Through the acquisition of the company Topcat, a comprehensive knowhow for the development of mouse traps was adopted and developed further.

Our outstanding standards of quality and our permanent focus on customer’s satisfaction mean that we continue to ensure the high Swiss quality of our products. With the aid of our own research and development department, we constantly improve our products and knowhow.

We distribute our own manufactured products as well as some high-quality trade products, all over the world, to more than 150 distributors. With some of them we have already maintained good business relations for more than 20 years!

INDuSTRIAS QuÍMICAS DEL VALLÉSAv. Rafael Casanova 81 08100 Mollet del Vallés Barcelona Spain

Tel: +34 93 579 66 77 Fax: +34 93 579 17 22

[email protected] www.iqvagro.com

IQV (Industrias Químicas del Vallés, S.A.) offers full toll manufacturing and logistic services. Certified according to ISO 9001, 14001 and EMAS; IQV has been approved by many multinationals and is proud to have them among its customers or partners.

IQV produces active ingredients, develops and improves recipes, formulates and conditions both liquid and solid pesticides, and offers purchase of packaging and raw materials, warehousing and distribution services. IQV listens to customers’ needs and is completely flexible regarding processes. In its two manufacturing units, IQV deals with more than 100 active ingredients, produces more than 30,000 mt of the different TG copper salts and more than 26,000 mt of ready-to-use formulations.

Recognized world leader in copper fungicides, IQV is involved in the development, production, commercialization and distribution of Plant Protection Products to provide

safer products for healthier crops worldwide. IQV has focused, basically but not only, on the development of Copper salts and mixtures thereof as fungicides for crop protection. Other products, sectors, activities, new production facilities, subsidiaries and markets abroad, partners and customers make up for the actual presence of IQV in all continents.

IQV owns around 450 registrations worldwide, mostly straight copper products, mixtures thereof and Metalaxyl-based fungicides.

IQV’s most well-known trademarks (Caldo Bordeles Vallés, Curenox, Bordo, Cupertine, Mevaxil and Armetil) are our cover letter in many countries.

At the EU level, IQV has defended Copper (the three main Copper salts: Bordeaux mixture, Oxychloride and Hydroxide) as member of the European Copper Task Force and Metalaxyl on its own. Both are now included in Annex I. Copper and Metalaxyl are IQV’s present and near future bets, while opportunities of new active ingredients are always welcome.

SERVICE COMPANY GUIDE CUSTOM MANUFACTURERS

FORMULATION COMPANIES & ADDITIVES SUPPLIERS SERVICE COMPANY GUIDE

Formulations companies & additives suppliers

AMEGA SCIENCES17 Lanchester Way Royal Oak Industrial Estate Daventry Northamptonshire NN11 8PH UK

Tel: +44 1327 704444 Fax: +44 1327 871154

[email protected] www.amega-sciences.com

Contact: Lynne Farrell

AmegA Sciences is a medium-sized UK manufacturing and marketing company with current sales in Europe and North America. AmegA Sciences has a reputation for the provision of a high quality, reliable service and for developing technically sound and innovative new products.

The main product areas are adjuvants, wetting agents, colourants, bio-stimulants, spray additives, tank cleaners for agriculture, horticulture and amenity turfgrass. Custom manufacturing, contract formulation and packing facilities are available for non-pesticidal product production.

CRODA300A Columbus Circle, Edison, NJ 08837-3907

Tel: 1 732 417 0800 Fax: 1 732 417 0804

[email protected], www.croda.com/cropcare

Contact: Rachel Lafferty

Croda Europe Ltd Cowick Hall Snaith, Goole East Yorkshire DN14 9AA, UK

Tel: & Fax: 01405 860551

[email protected] www.croda.com/cropcare

Contact: Joanne Hancox

Croda’s Crop Care business supplies formulation aids and adjuvants under respected brand

names such as Atlox™ and Atplus™. Our product ranges are engineered to bring value-added benefits to herbicides, fungicides, insecticides, and other crop care products.

Applications include emulsifiable concentrates (EC), microemulsions (ME), suspension concentrates (SC), concentrated aqueous emulsions (EW), soluble liquids (SL), suspoemulsions (SE), water dispersible granules (WG), wettable powders (WP), oil dispersions (OD), and seed coatings.

Both basic and generic producers choose Croda chemistries to improve formulation performance, reduce costs, and minimize the impact of pesticide formulations on our world.

EXwOLD TECHNOLOGY LIMITEDPO Box 270 Brenda Road Hartlepool TS25 2BW UK

Tel: 0044 1429 230340

www.exwold.com email: [email protected]

Contact: Sam Price

Exwold Technology Ltd is a contract processing and formulation company dedicated to servicing the Crop Protection & Speciality Chemical markets. We are recognised as specialists in the formulation and supply of low pressure extruded granules primarily for use as WDGs in the agrochemical market & have recently extended our capabilities in High Potency Herbicide formulation. We also supply a wide range of powder and granule processing technologies including granule impregnation and coating , compaction granulation and powder blending.

We provide a trusted, fast and flexible service to companies around the world. With our pilot facilities, we are able to support our customers through product development and finding solutions and are proud to be partners in chemical processing.


SBM-FORMuLATIONC.S. 621 – Z.I. Avenue Jean Foucault 34535 Béziers Cedex France

Tel: +33 4 91 24 44 35

[email protected] www.SBM-formulation.com

Contact: Denis Barlet General Manager

SBM-Formulation is a leading European toll formulation company providing an extended range of sophisticated technologies, including WG using fluidised bed or extrusion, RB or GB by wet processing , EW, SE,SC with a dedicated line for FS. SBM provides services to a wide range of crop protection companies including many of the majors.

SBM offers a full formulation and packing service through from early development stage. The main manufacturing and packaging plant is ISO 9001 is ISO 14001-certified.

SBM pays special attention to safety, environment and housekeeping aspects through a policy of continuous investment.

Iris, sister company of SBM-Formulation , is specialized in toll-packing for small packs (from 1g/mL to 1kg/L) for Ag. or Home and garden Business .

TAMINCOPantserschipstaat 207 Gent 9000 Belgium

Tel: +32 9 254 1586

[email protected] www.taminco.com

Contact: Guy Van Den Bossche

Taminco’s Crop Protection business unit offers clients 25 years’ experience in toll processing of WDG. The company’s processing technique, registered under the trade name Granuflo®, is based on the ‘spray-dry’ method and produces the best quality water-dispersible granules available on the market. Taminco has also invested in the production of flowable formulations both for seed treatment and for foliar uses. By making use of our Granuflo or flowable technology, clients can outsource their existing or develop their own WG, FS or SC formulation. The process includes an in-line filling system into the end users’ packaging, such as boxes, bags, drums or cans. For new contracts, tailor-made formulations are developed in Taminco’s laboratory and trial quantities can be obtained within three months from their pilot plant.

Taminco is also a leading supplier in specialized niche markets of soil fumigation and foliar fungicides. Contact us or check our website for more info.

SERVICE COMPANY GUIDE FORMULATION COMPANIES & ADDITIVES SUPPLIERS

SAFAPACStapledon Road Orton Southgate Peterborough Cambridgeshire PE2 6TB UK

Tel: +44 1733 367 650 Fax: +44 1733 367 651

[email protected] www.safapac.co.uk

Contact: Martin Steele

Safapac is one of Europe’s leading independent chemical formulations, blending and packing providers.

With over 20 years’ experience in providing for the service needs of companies, from small niche sales and marketing companies who do not have their own manufacturing facilities through to major blue chip organisations, Safapac can offer clients a ‘virtual factory’ facility.

The company focuses on offering a flexible range of manufacturing, packing and support services to the agchem industry.

Safapac’s facility at Junction 17 on the A1 in the UK, positions it ideally for access to the east coast ports, the channel tunnel and all London and Midland airports.


Should you wish to sponsor, exhibit or simply wish to ask a question, please contact us: by phone: +44 (0) 1423 863 522by email: [email protected]

The BCPC Congress2013: Focus on European Regulatory Affairs

1-2 OCTOBER | BRIGHTON | UK

REGISTER NOW Further information on speakers and programme is available from www.bcpccongress.org

Brighton is Back!Join us at the Premier

Regulatory Event of the YearA Unique Opportunity for Exhibitors

The exhibition will be the networking focus for all sectors of the plant production and

protection industry. The Congress will also have an informative and relevant programme of presentations, plus panel discussions, with key government and industry experts.

BCPC1-2 OCTOBER | BRIGHTON | UK

IN ASSOCIATION WITH

Media PartnerHeadline Sponsor Evening Event Sponsor


SERVICE COMPANY GUIDE INTERMEDIATE SUPPLIERS

Intermediate suppliers

BHARAT [email protected] [email protected]

www.bharatgroup.co.in

Contact: Mr SN Gupta, CMD/Mr Sanjay Gupta, Sr GM-International Business

Established three decades ago, Bharat Group is a multi-product, multi-locational and one of India’s leading Manufacturers and Exporters of large range of Pesticides Technical, their Formulations and Intermediates for Crop Protection, Public Health, Veterinary and Pharma Industry. Our motto of complete customer satisfaction has enabled us to reach turnover of USD 110 Millions. All of our Group Companies are ISO 9001:2008 and ISO 14001:2004 certified.

Bharat Rasayan Ltd., the flagship company of the Group manufacturing Technicals and Intermediates, has the capacity of 25000MT per annum (A new State of Art Manufacturing Plant at Dahej, Gujarat of capacity 15000MT/annum has commenced production recently). It is also a Govt. Recognized Star Export House.

Our Registration Department has ready dossiers for all products with full toxicology informations and thus the helping our customers in all possible means. GLP data is also available for Alphacypermethrin, Lambda Cyhalothrin, Cypermethrin, Permethrin, Clodinafop Propargyl, Bifenthrin, Ethion, Metribuzin & Chlorpyrifos. Data for other molecules can also be generated. Further our Technicals Lambda Cyhalothrin, Alpha cypermethrin and Chlorpyrifos are WHOPES approved

Some of our competitive products are: A) Synthetic Pyrethroids: Cypermethrin, Permethrin, Bifenthrin, Fenvalerate, Lambda Cyhalothrin, Chlorpyrifos, Chlorpyrifos Methyl, Ethion, Phenthoate and Clodinafop Propargyl.

B) Intermediates: MPBD, MPBAL and many more.

LANXESS DISTRIBuTION GmbHKatzbergstr. 1 40764 Langenfeld Germany

Tel: +49 (0) 2173 2033 158 Fax: +49 (0) 2173 2033 91158

Email: [email protected] www.lanxess-distribution.com

Contact: Ralf Bogan

LANXESS Distribution is a sales and distribution company within the LANXESS Group. LANXESS Distribution holds worldwide registrations for Diuron applications in corp protection. This business is supported by an OECD standard data package and integrated production with raw material from the LANXESS group. The company’s offpatent product portfolio includes further active ingredients and formulated products with proprietary registrations from well-known manufacturers. Customers include the corp protection industry, regional suppliers and co-operatives. The company supplies its customers with high quality products. Based on long term experience in the area of supply chain, LANXESS Distribution offers customer-tailored service for the agchem world.

LKC SwITzERLAND LTDHauptstrasse 10 Fullinsdorf 4414 Basel Land Switzerland

Tel: +41 61 906 8500 Fax: +41 61 906 8509

[email protected] www.LKC-ltd.com

Contact: Dr David Kane

LKC offer experience and strategic advice to clients who want to be successful in Europe.

Development and Registrations of Crop Protection Products, Biocides, Veterinary Medicines,

ANDERMATT BIOCONTROL AGStahlermatten 6 6146 Grossdietwil Switzerland

Tel: +41 62 917 51 25 Fax: +41 62 917 50 06

[email protected] www.biocontrol.ch

Contact: Erich Frank

Andermatt Biocontrol was founded in 1988 by Dr. Martin and Dr. Isabel Andermatt. In the meantime Andermatt Biocontrol is embedded in the family- and employee-owned Andermatt Holding, which has some 100 highly motivated employees.

BIOPESTICIDES SERVICE COMPANY GUIDE

BiopesticidesKey expertise of Andermatt Biocontrol is the development of new products based on baculoviruses and beneficial insects. Through the acquisition of the company Topcat, a comprehensive knowhow for the development of mouse traps was adopted and developed further.

Our outstanding standards of quality and our permanent focus on customer’s satisfaction mean that we continue to ensure the high Swiss quality of our products. With the aid of our own research and development department, we constantly improve our products and knowhow.

We distribute our own manufactured products as well as some high-quality trade products, all over the world, to more than 150 distributors. With some of them we have already maintained good business relations for more than 20 years!

Pharmaceuticals and specialized chemicals (REACH) are handled by our scientific experts.

We have technical and regulatory expertise to contract and monitor studies including higher tiered studies; to interpret the findings; to prepare the appropriate risk assessments and compile regulatory dossiers in both paper and electronic formats. We engage in dialogue with Regulatory Authorities and work with a network of global affiliates to provide a ‘big picture’ perspective for our clients.

LKC is a GLP Certified facility for directing multi-site studies to ensure the best scientific database for our clients.

Contact LKC to see how we can find solutions to your regulatory challenges.



TSGE LLPConcordia House St James Business Park Grimbald Crag Court Knaresborough North Yorkshire HG5 8QB UK

Tel: +44 (0) 1423 799633 Fax: +44 (0) 1423 797804

[email protected] www.TSGEurope.com

Contact: Alison Hamer

TSGE DEuTSCHLANDRichthofenstrasse 29 31137 Hildesheim Germany

Tel: +49 (0) 5121 708580 Fax: +49 (0) 5121 708589

[email protected] www.TSGEDeutschland.com

Contact: Hermann Wilhelmy

TSGE IBERIAAvenida de Galicia, 22, 5º Dcha 33005 Oviedo Asturias, Spain

Tel: +34 984 180 643 Fax: +34 984 180 634

[email protected] www.TSGEIberia.com

Contact: Maria Fernández

TSGE SLOVENIAŠpruha 19 1236 Trzin Slovenia

Tel: +386 1 729 7183 Fax: +386 1 729 7184

[email protected] www.TSGESlovenia.com

Contact: Bojana Zgonec

TSGE POLANDOddział w Polsce ul. Puławska 405 a 02-801 Warszawa Poland

Tel: +48 (0) 22 468 8121

[email protected] www.TSGEPoland.com

Contact: Aleksandra Gniado

A leading European regulatory consulting company, TSGE’s scientific, regulatory and registration specialists are actively engaged in obtaining and defending product registrations across Europe.

With offices located in the UK, Germany, Spain, Slovenia and Poland, our specialists can prepare active substance and product dossiers including lower to higher tier risk assessments in the areas of plant protection, biocides, animal health, REACH, cosmetics, food contact and consumer products. TSGE also successfully participates in and manages task forces and consortia.

TSGE EuROPEAN GROuP OF COMPANIES

SERVICE COMPANY GUIDE BIOPESTICIDES

TSG NORTH AMERICA

wASHINGTON DC OFFICE1150 18th Street, NW Suite 1000 Washington DC, 20036

CALIFORNIA OFFICE 712 Fifth Street Suite A Davis, CA 95616

Tel: +1 530 757 1245 Fax: +1 530 757 1299

www.TSGUSA.com

CANADIAN OFFICE7110 Cobble Hills Rd. R. #4 St Marys, ON N4X 1C7

www.TSGCanada.ca

Contact: Barb Yates [email protected]

Tel: +1 519 349 2985 Fax: +1 519 349 2986

TSG provides state, federal and international expertise on a wide range of scientific and regulatory issues. With experts in regulatory affairs, chemistry, toxicology, ecotoxicology, residue and metabolism, environmental fate, efficacy and risk assessment, TSG provides services in support of the registration, compliance and defence of chemically related products. Our clients include chemical, pesticide, fertilizer, consumer product, food, personal care and animal health companies, as well as industry groups, trade associations and law firms.

INDEX SERVICE COMPANY GUIDE

Consultancies & other advisory bodies APC...................................................................................3

Agri-Nova Technology Ltd ....................................................3

Amis Global ......................................................................3

Blue Frog Scientific Limited ................................................4

Compliance Services International (CSI) ...............................4

Cropnosis Limited ...............................................................4

Dextra International ............................................................5

DHD-Consulting GmbH .......................................................5

EBRC Consulting ................................................................5

Environ ..............................................................................5

Exponent International ........................................................6

Gab Consulting GmbH .........................................................6

JSC International ................................................................6

LKC Switzerland Ltd ...........................................................7

Phillips McDougall ..............................................................7

Protech Consulting .............................................................7

SCC Gmbh – Scientific Consulting Company ..........................7

TSGE.................................................................................8

TSG...................................................................................8

Xenex Associates ................................................................8

Market researchDextra International ............................................................9

GfK Kynetec .......................................................................9

Kleffmann Group ................................................................9

Specialty Products Consultants, LLC ....................................9

Contract research organisations Agrisearch Services ...........................................................10

Agroblu Hellas Ltd ...........................................................10

Agrochemex .....................................................................10

Agrolab A/S ......................................................................10

Anadiag ...........................................................................11

Agroblu ............................................................................11

Eurofins ...........................................................................12

Biotek Agriculture .............................................................13

Biochem Agrar GmbH .......................................................13

Biotecnologie B.T. SRL......................................................13

Cemas (CEM Analytical Services) .......................................14

Entomology Applied Research Laboratory ............................14

Field Research Support .....................................................14

Mambo-Tox ......................................................................15

Mylnefield Research Services Ltd .......................................15

NIAB ...............................................................................15

Oxford Agricultural Trials ...................................................15

Peracto ............................................................................16

Promo-Vert .......................................................................16

Promo-Vert Crop Services ..................................................16

Promo-Vert Crop Services Portugal ......................................16

Promo-Vert Hungaria KFT ..................................................16

Harlan .............................................................................16

Redebel ...........................................................................17

SGS Group .......................................................................17

Smithers Viscient ............................................................17

Syntech ...........................................................................17

Staphyt ............................................................................18

Trialcamp .........................................................................19

Versuchswesen Pflanzenschutz ...........................................19

Vigna Brasil......................................................................19

Wildlife International ......................................................19

Diagnostics & other suppliersHerbiseed ........................................................................20

Custom manufacturersAgri Life ..........................................................................21

Andermatt Biocontrol AG ...................................................21

Industrias Químicas del Vallés ...........................................21

Formulation companies & additives suppliersAmega Sciences ...............................................................22

Croda ..............................................................................22

Exwold Technology Limited ................................................22

Safapac ...........................................................................23

SBM-Formulation .............................................................23

Taminco ...........................................................................23

Intermediate suppliersBharat Group....................................................................25

Lanxess Distribution GmbH ...............................................25

BiopesticidesAndermatt Biocontrol AG ...................................................26

LKC Switzerland Ltd .........................................................26

TSGE...............................................................................27

TSG.................................................................................27


Contents

Biopesticides acquire mainstream status

pages I-V

Biopesticide-related corporate deals

page VIII

NZ weed biocontrol successespage IX

Fungal phytotoxins reviewedpages X-XI

Biopesticide patent watchpages XII-XIV

Biopesticide Development in China

pages XVI-XVIII

Biopesticides

www.agrow.com

A Professional Regulatory Affairs Service

. . . . . in plant protection and public health

What sets us apart• Consultants experienced in the scientific, regulatory and registration aspects of

biopesticide products

• Dedicated project management team

• Leading authorities in biopesticide regulatory affairs

Our expertise• Advising on regulatory procedures, strategy and data requirements

• Developing protocols for individual studies or full programmes

• Commissioning and monitoring studies and trials

• Specialist process for literature searching and review

• Data waiver rationales

• Preparation of study summaries, risk assessments and dossiers

• Managing submissions across the EU and North America

For further information, please contact:

TSGE in Europe:by phone: +44 (0) 1423 799 633 www.tsgeurope.com

TSG in North America:by phone: +1 530 757 1245 www.tsgusa.com

TSGE-13-A962 LLP Agrow Advert.indd 1 21/06/2013 15:26

Biopesticides acquire mainstream statusA � urry of corporate activity in biopesticides by big crop protection companies has cast the spotlight on this sector. Sanjiv Rana examines the implications for the biopesticide sector

The intervening year since the publication of Agrow’s � rst annual biopesticide supplement in April 2012 has been an eventful one, to put it mildly. One could even venture to say that the past several months have transformed the biopesticide sector, � rmly establishing it as an intrinsic part of the crop protection industry. Things have moved quite some way from Agrow’s proclamation last April that the sector was no longer considered fringe; when quite a few people within the biopesticide industry were still wary of the tag “snake oils”, and when the big crop protection companies were quite circumspect about their intentions regarding biopesticides and seemed to be merely testing the waters.

While most of the corporate activity during 2011 was focused on licensing deals, it shifted in 2012 to acquisitions with most big companies trying to gain access to technology to kick-start their biopesticide programmes.

Consider the � urry of activity among four of the Big Six since last April. In May 2012, Monsanto unveiled its biopesticide research initiative in the form of its RNA interference (RNAi)-based BioDirect technology. In July, Bayer CropScience set about acquiring US biopesticide company AgraQuest. The following month, Monsanto entered into a ten-year strategic alliance with US company Alnylam Pharmaceuticals to use Alnylam’s RNAi-based technologies in its BioDirect platform. The following

month, Syngenta acquired US biopesticide company Pasteuria Bioscience. The very next day, Agrow reported BASF’s acquisition of US biopesticide producer Becker Underwood. October witnessed Syngenta signing an exclusive global marketing and distribution deal with Danish company Novozymes to commercialise the Bacillus subtilis-based biofungicide, Taegro.

Deals continued into the

new year. Bayer started this year with a bang by acquiring German biopesticide company Prophyta. Syngenta followed that up with a regionally exclusive distribution deal with Italian agrochemical company Isagro for its Trichoderma asperellum and T gamsii-based biofungicide. And we are not even counting the deals and acquisitions sealed by medium-sized and smaller companies in di� erent parts of the world (details on p VIII).

Do other biopesticide companies view these acquisitions as a threat?

While the big guns were busy wheeling and dealing, biopesticide industry stalwarts including US companies Marrone Bio Innovations (MBI) and Sumitomo Chemical subsidiary Valent BioSciences (VBC) were busy building production facilities for their respective products. In August, MBI acquired a facility and expects to begin production there this year. VBC began construction of its facility in 2012 and expects it to come on stream in spring 2014. VBC chief operating o� cer Mike Donaldson says that controlling the manufacturing process from beginning to end, rather than going to third-party toll manufacturing, is absolutely essential in maintaining the special requirements of a global biopesticide business, while continuously reducing cost. “Without dedicated manufacturing control, it will be di� cult to maintain quality and control costs of biopesticides on a worldwide basis,” he explains.

MBI founder and chief executive o� cer Dr Pamela Marrone points towards many successful companies that were in existence before the current wave of mergers and acquisitions. “If you look in any mature industry, there are always new entrants with disruptive and new innovations who become successful,” she says. She explains that innovation and speed are key and it is not so easy to develop a biopesticide from scratch.

Dr Marrone says that MBI is in a “safe place” as it has products on the market, and in the pipeline, across all pest categories. A small biopesticide company built only around one technology does not possess enough clout with the channel and hence the only realistic exit strategy is to sell the company, she adds. “With a productive and e� cient R&D, MBI has several new active ingredients that we are mixing and matching together and with chemicals,” Dr Marrone declares.

continued on page II . . .

©Informa UK Ltd 2013 www.agrow.com I

Biopesticides

Valent BioScience’s Mike Donaldson says that dedicated manufacturing is essential in maintaining the special requirements of a global biopesticide business

Mr Donaldson echoes that con� dence. “VBC is currently the largest single company dedicated to the development, manufacturing and commercialisation of a diverse portfolio of biorational products on a global basis,” he says. The company sells products in 95 countries around the world, having expanded its product o� ering beyond “just biopesticides” to a category it de� nes as “biorational” products, which includes not only traditional biopesticides but also plant growth regulators (PGRs). The product range allows it to participate in all market segments from seed treatment to post-harvest products. He points towards its recent acquisition of US post-harvest treatment specialist, Pace International, as a step towards further expansion. He also highlights the company’s manufacturing facility that is being built completely based on ongoing cash � ow returns of VBC, “a key indicator of our sustained success in this segment”.

So how do biopesticides � gure in the strategic plans of these companies?

“Overall, we see chemical and biological pesticides as complementary,” says BASF’s Functional Crop Care senior vice-president, Juergen Hu� . He points to Becker Underwood’s existing biopesticide products for seed treatment such as its BioStacked technology that enables it to combine inoculants, growth enhancers, biofungicides and polymers on crop seeds. “This combination will provide excellent protection for high-value seeds and yield gains for the grower,” explains Mr Hu� .

BASF says that future applications of biologicals in row crops will not be limited to seed treatments. The company plans to continue to focus its R&D on biopesticide products for seed treatment as well as for � eld use. It says that in addition to the BioStacked technology for seed treatment, Becker Underwood

already provides biopesticides for � eld use, such as the bioinsecticide, BroadBand (Beauveria bassiana strain PPRI 5339), which is registered for the control of red spider mites (Tetranychus spp), thrips, white� ies (Bemisia tabaci) and diamondback moths (Plutella xylostella) on speci� ed � eld crops, or the bionematicide, PL Gold (Paecilomyces lilacinus strain BCP2), a second-generation ovicide product for the control of parasitic nematodes.

Bayer outlines its strategic focus as one of o� ering farmers integrated crop solutions based on seeds, chemicals and biologicals. The company says that although the highest growth rate of biopesticides has been observed in fruits and vegetables, there are additional growth opportunities in broad-acre crops such as oilseed rape and maize.

Syngenta has a similar view and sees � eld applications in row crops as potential future uses for biopesticides. It does caution, however, that such use would depend on the product (with its biological performance and technical aspects) as well as the target pest or disease it aims to control, at commercially viable costs for the farmer. The company views biopesticides as important additions to its integrated solutions for growers. It does not exclude their potential solo use where it makes sense, but believes that the majority of uses will involve complementary, sustainable chemical technologies as well.

MBI points out that one of the advantages of using biopesticides on row crops is that their application in combination with chemicals a� ords greater yields than the use of chemicals alone. It highlights its � eld results on soybeans and maize, which show that the biofungicide, Regalia (Reynoutria sachalinensis extract), adds 3-5 more bushels/acre when combined with a strobilurin fungicide as a foliar spray. It says that it is selling Regalia this year for this purpose. Dr Marrone also points towards combinations of biopesticides. “We expect to develop multiple ai bioherbicides, bioinsecticides and biofungicides,” she says.

VBC says that biopesticides (for seed protection) and biorationals (for in-season foliar applications and physiological seed enhancement) are becoming important components of many seed management programmes in both horticultural and arable crops. “In most cases, based on the limited spectrum of either protection or of physiological responses of these products, they will be used in combination with conventional chemistry,” says Mr Donaldson.

The company points out the opportunity of creating proprietary mixtures utilising its existing and pipeline products. It has a global patent portfolio of over 175 patents related to biorational products, formulations and uses for both stand-alone and combination biorational products.

Do biopesticides have su� cient e� cacy to be able to be launched separately as products?

BASF believes that biologicals will have a meaningful role to play in helping growers to protect and boost their yields. It points out the challenges, such as limited shelf-life, that arise out of dealing with living organisms, but it sees a high potential for future innovation in these areas. “We expect to see biologicals in the market with su� cient e� cacy as stand-alone products as well as biologicals tailored for applications in combination with classic chemistries,” the company adds.

II www.agrow.com ©Informa UK Ltd 2013

Biopesticides

. . . continued from page I

BASF’s Juergen Hu� views chemical and biological pesticides as complementary

Bayer highlights the use of biopesticides in a variety of scenarios o� ering varying degrees of e� cacy. Some are designed for speciality production models. Other biologicals/chemicals, such as Votivo (Bacillus � rmus + clothianidin), can be used alongside chemical crop protection products (in tank mixes or alternation programmes) to deliver comparable performance to standard crop protection products. Still others, including Serenade Soil (Bacillus subtilis strain QST 713), compete very e� ectively against chemical crop protection products in terms of disease control and yield bene� ts.

Syngenta says that the performance of biopesticides has improved over the years and they can be launched as individual products. When used in combination with chemicals, high-quality seeds and established good agronomic practices, their performance can be signi� cantly enhanced, it adds.

Are existing formulation technologies suitable for biopesticides?

A lack of formulation technologies speci� cally designed to meet the special needs of biopesticide products is often cited as one of the factors hindering their wider usage. “For biopesticides to truly become mainstream global products, active ingredients must be developed along with formulations that provide attributes speci� c for the biopesticide industry,” explains Mr Donaldson. This can only come from experience dealing with these types of products in real world commercial environments, he adds.

Dr Alan Baylis, owner of UK consultancy Nuvistix Innovation and author of Agrow’s forthcoming report on biopesticides, says that formulation needs to take into account not only that e� cacy will be particularly dependent on environmental conditions, but that it will also be necessary to ensure stability of living organisms in distribution and storage. A related issue would be that packaging might need to provide gas and water

exchange. Also, farmers would generally want to use the same application equipment as for chemical products.

Dr Alan Knowles, director at UK consultancy Form-AK and author of Agrow’s forthcoming report on formulations, feels that there may be synergy in some cases between chemical pesticides and biopesticides as suitable mixtures may also help to overcome resistance problems. “However,

formulation of mixtures may not be straightforward in many cases,” he cautions. He says that stability issues need to be researched.

Among formulation objectives for biopesticides, Dr Knowles lists: maintaining stability of the ai during processing and on storage and application; protecting the ai against degradation or loss of e� ectiveness on exposure to UV light; maintaining viability and e� ectiveness of the ai in the presence of other formulation components, especially for living organisms; and improving e� ectiveness of the ai under low humidity conditions, especially for living systems.

Biopesticide formulations are normally aimed at providing special attributes to this product category that include enhanced stability of a biological based ai, as well as providing good plant coverage that allows for maximum e� cacy in the � eld, Mr Donaldson further explains. Without product stability, it is di� cult to have a truly global product that can be used in multiple markets. And without good coverage, products that rely on coverage for e� cacy, such as biopesticides for plant protection or other biorational products such as PGRs, will not perform in a predictable and consistent way, he adds.

BASF stresses this point as well, saying that because biologicals contain living organisms, speci� c fermentation and formulation technologies are required to cope with and overcome various challenges, such as in the area of shelf-life, quality or broad applicability. It says that Becker Underwood has in-depth experience in fermentation and formulation technologies for biologicals and that the combination of the two companies’ technologies would open up many untapped innovation options. “We will continue to expand our technology base in this area, as it is crucial for growers’ continued success worldwide,” adds Mr Hu� .

Bayer points towards Prophyta´s patented solid-state fermentation technology and strong expertise in the formulation of living fungal spores, use of which will help it bring new solutions to market. The company also highlights its long-time formulation expertise and the potential for future products.

Syngenta says that while formulations for biologicals have signi� cantly improved over the last few years, it believes that

continued on page IV . . .

II www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com III

Biopesticides

UK consultancy Form-AK’s Dr Alan Knowles feels that formulation of mixtures of chemical pesticides and biopesticides may not be straightforward in many cases

UK consultancy Nuvistix Innovation’s Dr Alan Baylis says that formulation needs to ensure stability of living organisms in distribution and storage

there is still plenty of room for further innovation. The company is applying its extensive formulation expertise, built over decades, to innovative biological formulations, it says.

Have there been changes in user perceptions in terms of e� cacy and cost of biopesticides?

The use of biopesticides in combination with conventional pesticides and improvement in formulations are expected to help alleviate some of the negative perceptions about the products among growers. “The perception of e� cacy and cost e� ectiveness is improving but there are still lingering perceptions that biopesticides are not as strong as chemicals and are higher priced,” admits Dr Marrone.

Mr Donaldson says that changing the sometimes negative perception about cost and e� cacy of biopesticides is a slow process and can only be done through credible public relations and awareness campaigns from the selling companies and actual positive use by existing and new customers. He says that increased participation by larger, credible companies, has led to an informed message being projected to the marketplace that is factual with claims that can be consistently veri� ed. He complains about some unrealistic claims being made by some market participants that slow the conversion to a positive perception.

Do biopesticides face an easier regulatory approval process?

Dr Marrone says that regulatory requirements are getting more burdensome rather than better. She says that often a non-reduced risk chemical takes less time to get through the US EPA than most new biopesticide ais. She complains that registrants often � nd new non-standard requirements added very late in the process within days of the approval due date, forcing re-negotiations of statutory approval dates, making the process very unpredictable. “We are required to submit a � le cabinet drawer of data to the EPA, while a chemical requires a truckload. It should not take more time to review a � le drawer of data,” she complains. Dr Marrone says that the reason for the passage of the PRIA (Pesticide Registration Improvement Act)

by the US Congress was to provide predictable timelines. “The unpredictability is a killer for small companies. Indeed, we know companies that have gone out of business, millions of dollars of revenues and hundreds of jobs lost,” she says.

Mr Donaldson expresses a similar thought, saying that as many biopesticides have particular toxicological attributes that inherently put them in a category of reduced risk, it is important to take these characteristics into account when establishing registration regulations. “But over the years, the degree of stringency surrounding the registration of biopesticides has been increasing, just as it has with conventional chemistry,” he says. That poses questions about how much a company can spend on a biopesticide registration when viewed against the market opportunity and return on investment.

Philip Kessler from Swiss company Andermatt Biocontrol talks about similar problems in the EU where high investments and uncertainties could be killing factors to registration of biopesticide for niche markets. He gives the example of Andermatt’s baculovirus-based bioinsecticide, Capex (Adoxophyes orana granulovirus), the EU approval process for which took eight years after the submission of the registration dossier in 2004. He places the costs of registration of Capex in the EU at €850,000-950,000 ($1.1 million-1.2 million), which included: costs for the OECD data package at some €700,000 ($907,000); cost for consultants at €25,000 ($32,000); fees for the rapporteur member state, Germany, including provisional approval also at €25,000 ($32,000); costs for e� cacy trials in member states at €50,000-100,000 ($65,000-130,000); and expected costs of mutual recognition from Germany to other member states within the central zone again at €50,000–100,000 ($65,000-130,000).

Mr Kessler feels that, in hindsight, it did not make commercial sense for the company to get the product registered in the EU given the � uctuating annual market for Capex of €50,000-200,000 ($65,000-260,000). In addition to a shorter evaluation period, he calls for better transparency and communication between regulators and industry. He gave a thumbs up to the EU project started in 2008 under guidance document SANCO 0235/2008 for the registration of baculoviruses, dubbed REBECA. It involved better communication with authorities at member state and Commission level.

Mr Donaldson highlights the niche nature and fragmented markets for biopesticide products while cautioning that as regulatory requirements go up, the availability of biopesticides will be limited by this. He stresses the need for the industry to be involved with the regulators.

Dr Venkatesh Devanur, managing director of Indian biopesticide company Agri Life, talks about the regulatory situation in India, which has traditionally been favourable towards biopesticides. But changes in the regulatory system have meant that

. . . continued from page III

IV www.agrow.com ©Informa UK Ltd 2013

Marrone Bio Innovations’ Dr Pamela Marrone says that regulatory requirements are becoming increasingly burdensome

Biopesticides

biopesticides are evaluated in the same way as chemical ais. Registrations of new biopesticides have fallen drastically during the past year even as over 400 registrants lost authorisations because of the change in policy. “Small and medium-scale companies will � nd it hard to remain in the market,” he says.

outlook

Indications are that the frequency of acquisition and deal-making activity will continue. Bayer was among the � rst of the big companies to profess its intentions of including biopesticides in its strategic planning by acquiring Israeli company AgroGreen’s Bacilllus � rmus-based bionematicides, BioNem and Votivo, in 2009. A B � rmus-based bionematicide

seed treatment was among the six ais that the company earmarked for launch by 2012 with combined peak annual sales of €1,000 million ($1,280 million).

“The acquisition of AgraQuest gave us a strong position in bacterial-based biologics, while the acquisition of Prophyta means we have a strong platform for fungal-based biologics,” Bayer says. It expresses openness to further investments

and collaborations to support its growth strategy. The company adds the caveat that opportunities would need to add value to its presently established Biologics platform comprising its AgraQuest and Prophyta assets, expertise and know-how.

Syngenta echoes the sentiment, saying that it is always open to adding technologies or products to expand and enhance its portfolio. It will “carefully evaluate” interesting opportunities and decide on the appropriate next steps.

BASF points towards its Functional Crop Care unit as one of its main growth � elds. The unit, which includes seed treatments and biopesticides, was created at the beginning of the year after the Becker Underwood acquisition. BASF says that it acquired the biopesticide company because its portfolio is an excellent complement to BASF’s seed treatment and Functional Crop Care portfolio. “In order to extend our technology basis in this strategically important area, we will continue to broaden our interdisciplinary work within R&D as well as leverage external partnerships and consider potential acquisitions,” says Mr Hu� .

Monsanto’s RNAi-based BioDirect biopesticide platform focuses on products for weed, insect, and virus control. The company says that early testing under the BioDirect programme for glyphosate-resistant weed control indicates that it can be used with glyphosate to target weeds and provide a broader spectrum of control on problem weeds.

Dr Devanur feels that the involvement of the larger companies has provided biopesticides the credibility that they had been lacking all these years. The move will lead to consumers taking the concept of biopesticides more seriously.

Dr Marrone says that having big companies sell biopesticides does give the sector more credibility with channel partners and key in� uencers like university researchers.

Mr Donaldson concurs, saying that because of the increased interest from major multinational agricultural companies, there has come an increased promotion of the biopesticide category by companies who have a lot of credibility and market access capabilities. This will help to increase the positive perception of biopesticides at the key in� uencer and customer standpoints.

He emphasises the lack of new biopesticide ai technologies that can provide broad-based solutions approaching the spectrum of those of conventional chemicals as a limiting factor. But he feels that the consolidation of the biopesticide industry can provide increased focus on capabilities for discovery activities, as well as development of new products that could not be justi� ed by smaller companies.

Agrow will continue to monitor developing trends through the rest of the year and provide you a detailed insight in the next annual biopesticide supplement. Hasta la vista!

EU regulationsIn the EU, biopesticides are covered by the EU agrochemical registration Regulation (1107/2009), which does not have any speci� c provision favourable to biopesticides in the form of an easier approval process. Article 22 of the Regulation covers low-risk ais, which have an authorisation period of 15 years and a faster approval process than for higher risk ais with a 120-day timeframe for evaluation by the zonal rapporteur member state. The Regulation favours the inclusion of low-risk ais in crop protection products by facilitating their placement on the market. But biopesticides are not considered low-risk by de� nition. To be considered such, they would need to ful� l the criteria listed in point 5 of Annex II of the Regulation. The industry feels that the approval process for biopesticides could be facilitated if new criteria were set for them as low-risk ais.

IV www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com V

Agri Life’s Dr Venkatesh Devanur feels that the involvement of the larger companies has provided credibility to biopesticides

Biopesticides

MBI Highlights

MBIMarrone Bio Innovations, Inc. (MBI) is a leading global provider of bio-based pest management and plant health products for the agricultural crop protection and water treatment markets. Comprised of naturally occurring microorganisms and plant extracts, MBI’s effective and environmentally friendly products provide improved plant health, crop yield, and quality while managing pesticide resistance and residues. MBI's crop protection products are primarily applied in conventional production programs with chemical pesticides, and are suitable for

organic operations as well. The company is also addressing new markets where there are no available conventional chemical pesticides or whether the use of such pesticide is not desirable or permissible because of health and environmental concerns.

With the global population soaring, the world’s food production by the year 2050 will need to double according to current estimates. Protecting crops and improving yields will require new product solutions that not only control pests, but also address consumer and legislative concerns focused on health and the environment. MBI’s bio-based pest management products (line of biopesticides) are part of this solution. They are exempt from conventional chemical residue

tolerances, limit the development of pest resistance, have low toxicity, and pose low risk to non-target organisms including mammals, birds, fish, and beneficial insects.

MBI’s award-winning fungicide and bactericide, Regalia®, is currently sold in North America, Latin America, and select European countries, treating foliar and soil diseases of food and ornamental crops. Grandevo®, the company's EPA-approved insecticide, was named "Best New Biopesticide" by Agrow in 2012 and represents the first new cross-spectrum microbial insecticide to enter the market in nearly 50 years. Aiding in resistance management, providing long-lasting control of chewing and sucking insects and mites, and featuring a flexible application window, Grandevo is paving the way for new, innovative uses of microbial insecticides in modern pest management.

Further expanding its crop protection portfolio, the company recently received EPA approval of a novel bioherbicide, and has submitted another cross-spectrum insecticide to the EPA. As part of its growth strategy, MBI is entering into strategic agreements to distribute its crop protection products to markets outside of its core sales territory of high-value specialty crops in the US.

MBI discovers new products through its efficient, proprietary discovery and development platform and by in-licensing select technologies. MBI has developed both a portfolio of EPA-registered biopesticides and a pipeline of new bio-based products in early and late stages of development, including herbicides, insecticides, and nematicides. All of MBI’s offerings address the growing global demand for effective, safe, and environmentally responsible products.

• Founded 2006

• Bio-based pest management and plant health products for agricultural crop protection and water treatment

• Commercial products: Regalia® fungicide, Grandevo® insecticide, Zequanox® aquatic molluscicide

• Herbicide received EPA approval; EPA approval pending for a second insecticide; several more products in the pipeline including herbicides, insecticides, nematicides, and algaecides

�• Over 180 patents pending in the U.S. and abroad

• Primary use in conventional agricultural, turf, ornamental and greenhouse IPM programs; also organic certifications

• Products improve plant health and quality, and help improve yield

• Products boost efficacy of traditional pesticides and provide alternative treatments to improve resistance management programs

• Dual strategy of early stage in-licensing and internal development

ADVERTORIAL

Contact Info:

(p) 530.750.2800 (e) [email protected] www.marronebioinnovations.com

At Marrone Bio Innovations, our mission is to discover, develop, and market breakthrough biopesticides for managing weeds, pests and plant diseases.

Grandevo®, our new cross-spectrum insecticide, was named the 2012 Best New Biopesticide by Agrow. It joins Regalia®, our soil and foliar biofungicide, that won the same distinction in 2010. Both Regalia and Grandevo deliver efficacy equivalent to synthetic pesticides to strengthen integrated pest management programs, reduce residues, and help improve quality, plant health, and yields.

Committed to meeting the needs of growers today and tomorrow, Marrone Bio Innovations continues to develop a growing pipeline of new crop protection products.

Visit us at www.MarroneBio.com for more information. Marrone Bio Innovations, Regalia, and Grandevo are trademarks of Marrone Bio Innovations. ©2013 Marrone Bio Innovations, Inc.

And we deliver time and again.

Biopesticide-related corporate deals (May 2012 onwards)

US pesticide development company Vestaron raised $10.2 million for the continued development of biopesticides based on spider venom toxins.

Italian agrochemical company Isagro’s US subsidiary, Isagro USA, appointed US biopesticide � rm AgraQuest as distributor for the biofungicide, Bio-Tam (Trichoderma asperellum strain ICC 012 + T gamsii strain ICC 080), for agricultural crops in the US.

Swiss biopesticide company Andermatt Biocontrol acquired a 24.9% share of German biopesticide company AbiTep.

Bayer CropScience agreed to acquire US biopesticide company AgraQuest for $425 million plus milestone payments.

The Japanese CBC group acquired Italian biopesticide company Intrachem Bio Italia.

US biopesticide company Marrone Bio Innovations acquired a manufacturing facility in Bangor, Michigan.

Monsanto entered into a ten-year strategic alliance with US pharmaceutical company Alnylam Pharmaceuticals to use Alnylam’s RNAi-based technologies in its BioDirect biopesticide platform.

Dutch bioproducts company Koppert Biological Systems opened a branch in South Africa in a joint venture with its former distribution partner, Vista Verde.

Syngenta acquired US biopesticide company Pasteuria Bioscience for $86 million, with additional deferred payments of up to $27 million.

BASF acquired US specialty products company Becker Underwood in a deal worth $1,020 million.

US biopesticide company BioWorks entered into a non-exclusive Canadian distribution agreement with CanHorta Canadian Horticulture Alliance.

Syngenta and Danish company Novozymes signed an exclusive global marketing and distribution agreement to commercialise the Bacillus subtilis-based biofungicide, Taegro.

US agrochemical company Gowan signed an exclusive agreement with Czech biopesticide � rm Biopreparáty to commercialise its Pythium oligandrum-based biofungicide,

Polyversum, in the NAFTA region.

Arysta LifeScience and French sustainable agricultural technology company Laboratoires Goëmar agreed two deals to develop each other’s biopesticide and biostimulant products. Arysta acquired exclusive rights to Goëmar’s Natural Protect technology related to the biopesticide, VacciPlant (laminarin), and Physio Activator biostimulant technology in central Europe and in the CIS countries. Goëmar received access to Arysta’s biopesticide and biostimulant products in France and other countries in western Europe.

Sumitomo Chemical’s US biopesticide and biorational products subsidiary, Valent BioSciences, agreed to acquire the US post-harvest treatment specialist, Pace International, for $65 million.

2013Bayer agreed to acquire German biopesticide company Prophyta.

Marrone Bio Innovations appointed Canadian agrochemical company Engage Agro’s US subsidiary, Engage Agro USA, as the exclusive marketer of MBI’s biofungicide, Regalia PTO (Reynoutria sachalinensis extract), in the US.

Brazilian pharmaceutical company Uniao Quimica acquired the Brazilian bioinsecticide � rm, Saneantes Biologicos Bthek.

Italian agrochemical company Isagro agreed a regionally exclusive distribution deal with Syngenta for its T asperellum and T gamsii-based biofungicide. The arrangement covers Europe, the Middle East and Africa.

Marrone Bio Innovations appointed Canadian agrochemical company Engage Agro’s US subsidiary, Engage Agro USA, as the exclusive US distributor of MBI’s bioinsecticide, Grandevo PTO (Chromobacterium substugae strain PRAA4-1T).

French crop protection company De Sangosse acquired a stake in UK biopesticide company Alpha Biopesticides and will be the exclusive distributor of Alpha Biopesticides products in France in the agriculture, home and garden, and amenities sectors.

VIII www.agrow.com ©Informa UK Ltd 2013

Biopesticides

A review of the e� cacy of biocontrol agents introduced to control invasive weeds in New Zealand has con� rmed the variation in success rates. Bene� ts from the 33 introductions targeting 23 weed species considered by the review ranged from massive to negligible, according to the � ve-point scale used by New Zealand’s Environmental Protection Agency (EPA), which considers economic, social and environmental risks and bene� ts. Around two-thirds (23) of the introductions had a negligible or minimal bene� ts, two had minor, � ve moderate, one major and two massive bene� cial e� ects. Overall bene� ts to the New Zealand economy from introduced biocontrol agents are estimated at NZ$11-21 million (US$9-17 million) per year.

The review cites four case studies as exemplars. Assessed as having a moderate e� ect on its target, the nodding thistle (Carduus nutans), the nodding thistle crown weevil (Trichosirocalus horridus) was introduced in 1982 and e� ected a decline in its target weed in many areas across New Zealand. It also attacked six other non-native thistles. Its control activity has been unexpectedly bolstered by the introduction of a second biocontrol agent, the Californian thistle gall � y (Apion onopordi), introduced to combat the Californian thistle (Cirsium arvense). The e� cacy of this latest introduction has not yet been determined.

The ragwort � ea beetle (Longitarsus jacobaeae) has been spectacularly successful against its target, ragwort (Senecio jacobaea), achieving a 90-100% reduction in populations within four years at many sites. Spread of the biocontrol agent across New Zealand seems to have been limited by high rainfall, the review notes. Economic bene� ts from the introduction of L jacobaea are estimated to be around US$5 million.

The introduction 60 years ago of the lesser St John’s wort beetle (Chrysolina hyperici) to control St John’s wort (Hypericum perforatum) is also considered to have ”massive” bene� ts. The weed, which had become the dominant species in large areas of pasture, has been so severely a� ected by C hyperici that it no longer features on regional pest management strategies.

The introduction of white smut fungus (Entyloma ageratinae) to control mist � owers (Ageratina riparia) in 1998 has brought major bene� ts, the review notes. The fungus has spread to all areas that the weed infests, reducing the mean percentage cover of mist � ower from 81% to 1.5% over � ve years.

Given that most of the costs associated with the introduction of a novel biocontrol agent are incurred prior to release, the review notes that further work is needed to maximise establishment. The review has been published in the journal, Biological Control.

Control Target Effectragwort � ea beetle (Longitarsus jacobaeae) ragwort (Senecio jacobaea) massive

lesser St John’s wort beetle (Chrysolina hyperici) St John’s wort (Hypericum perforatum) massive

White smut fungus (Entyloma ageratinae) mist � ower (Ageratina riparia) major

alligator weed beetle (Agasicles hygrophila) alligator weed (Alternanthera philoxeroides) moderate

alligator weed moth (Arcola malloi) alligator weed (Alternanthera philoxeroides) moderate

heather beetle (Lochmaea suturalis) heather (Calluna vulgaris) moderate

nodding thistle crown weevil (Trichosirocalus horridus) nodding thistle (Carduus nutans) moderate

nodding thistle gall � y (Urophora solstitialis) nodding thistle (Carduus nutans) moderate

broom seed beetle (Bruchidius villosus) Scotch broom (Cytisus scoparius) minor

Mexican devil weed gall � y (Procecidochares utilis) Mexican devil weed (Agaratina adenophora) minor

Californian thistle gall � y (Urophora cardui) Californian thistle (Cirsium arvense) minimal

cinnabar moth (Tyria jacobaeae) ragwort (Senecio jacobaea) minimal

gorse pod moth (Cydia succedana) gorse (Ulex europeus) minimal

gorse seed weevil (Exapion ulicis) gorse (Ulex europeus) minimal

gorse spider mite (Tetranychus lintearius) gorse (Ulex europeus) minimal

nodding thistle receptacle weevil (Rhinocyllus conicus) nodding thistle (Carduus nutans) minimal

St John’s wort gall midge (Zeuxidiplosis giardia) St John’s wort (Hypericum perforatum) minimal

gorse thrips (Sericothrips staphylinus) gorse (Ulex europeus) negligible

greater St Johns wort beetle (Chrysolina quadrigemina) St Johns wort (Hypericum perforatum) negligible

phoma leaf spot (Phoma clematidina) old man’s beard (Clematis vitalba) negligible

ragwort seed � y (Botanophila jacobaeae) Ragwort (Senecio jacobaeae) negligible

Californian thistle stem miner (Apion onopordi) Californian thistle (Cirsium arvense) undetermined

Source: Biological Control; Biological Control Australia New Zealand (BCANZ) database.

NZ weed biocontrol successes

– compiled by Hazel Blake

VIII www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com IX

Biopesticides

Brazilian researchers have completed a review of the methods used to identify phytopathogens with potential for use as bioherbicides. The review covers the main research strategies currently employed for the isolation and identi� cation of such compounds, including: the processes involved in isolating fungal phytotoxic metabolites; the factors a� ecting in vitro biosynthesis of phytotoxins, extraction and fractionation methods; the bioassay-guided fractionation procedure; and the bioassays most commonly used for monitoring isolation processes.

The review notes that several factors have contributed to the dearth of new herbicides including costs related to meeting regulatory requirements for new products and the maintenance of synthesis programmes as well as the surging popularity of herbicide-tolerant crops. As a result, no major herbicides with modes of action unrelated to those of existing products have been introduced in the past 20 years, it points out.

Phytotoxins produced by phytopathogenic fungi are generally

low molecular weight secondary metabolites that induce speci� c symptoms. Toxins may be broadly divided into those responsible for pathogenicity that are often e� ective against only host species of the parent fungi (see Table 1), and those contributing to virulence that are e� ective against a wider range of species (Table 2). An individual phytotoxin may be produced by not just di� erent species, but di� erent genera, the review notes.

Fungal phytopathogens and synthetic herbicides share little similarity in their modes of action, making them particularly attractive in combating weed resistance issues. Phytotoxins that may be unsuitable for direct use as a commercial herbicide may identify new sites of herbicidal action as potential targets for synthetic products, the review notes. Structural elucidation of an isolated phytotoxin can facilitate the development of a synthetic analogue with improved biological activity.

Details of the study have been published in the journal, Crop Protection.

Table 1: Fungal phytotoxins for potential species-specifi c biocontrolSource Phytotoxin Possible Biocontrol TargetBipolaris euphorbiae NK Euphorbia heterophylla

Alternaria cinerariae, A zinnia; Curvularia eragrostidis QZ2000

a,b -dehydrocurvularin Xanthium occidentale; Digitaria sanguinalis

Ascochyta caulina ascaulitoxin aglycone Chenopodium album

Ascochyta sonchi ascosonchine Sonchus arvensis

Fusarium moniliforme fumonisin B1 Lemna pausicostata

Fusarium spp, especially F oxysporum f sp lili fusaric acid methyl ester (5-butylpicolinic acid) Striga spp

Phyllosticta cirsii phyllosictine A Cirsium arvense

Source: Crop Protection.

Table 2: Broad-spectrum fungal phytotoxinsPhytotoxin Source MoAAnhydro-D-glucitol Fusarium solani sugar metabolism disruptor

Beticolin Cercospora beticola membrane function disruptor

B-nitroproprionic acid Septoria cirsii succinate dehydrogenase inhibitor

Cercosporin Cercospora spp photosensitiser

Cerulenin Cephalosporium cerulens lipid synthesis inhibitor

Cinnacidin Nectria spp DA060097 jasmonic acid analogue

Colletotrichin Colletotrichum spp membrane function disruptor

Cornexistin Paecilomyces variotii amino acid transferase inhibitor

Cyperin Preussia fl eischhakii; Phoma sorghina; Ascochyta cypericola

lipid synthesis inhibitor; PPO inhibitor

Cytochalasin Phoma exigua; Zygosporium masonii mitosis disruptor

Elsinochromes Elsinoe fawcetti photosensitiser

Fusicoccin Fusicoccum amygdali (Phomopsis amygdali) membrane function disruptor

Fungal phytotoxins reviewed

X www.agrow.com ©Informa UK Ltd 2013

Biopesticides

Brazilian researchers have completed a review of the methods used to identify phytopathogens with potential for use as bioherbicides. The review covers the main research strategies currently employed for the isolation and identi� cation of such compounds, including: the processes involved in isolating fungal phytotoxic metabolites; the factors a� ecting in vitro biosynthesis of phytotoxins, extraction and fractionation methods; the bioassay-guided fractionation procedure; and the bioassays most commonly used for monitoring isolation processes.

The review notes that several factors have contributed to the dearth of new herbicides including costs related to meeting regulatory requirements for new products and the maintenance of synthesis programmes as well as the surging popularity of herbicide-tolerant crops. As a result, no major herbicides with modes of action unrelated to those of existing products have been introduced in the past 20 years, it points out.

Phytotoxins produced by phytopathogenic fungi are generally

low molecular weight secondary metabolites that induce speci� c symptoms. Toxins may be broadly divided into those responsible for pathogenicity that are often e� ective against only host species of the parent fungi (see Table 1), and those contributing to virulence that are e� ective against a wider range of species (Table 2). An individual phytotoxin may be produced by not just di� erent species, but di� erent genera, the review notes.

Fungal phytopathogens and synthetic herbicides share little similarity in their modes of action, making them particularly attractive in combating weed resistance issues. Phytotoxins that may be unsuitable for direct use as a commercial herbicide may identify new sites of herbicidal action as potential targets for synthetic products, the review notes. Structural elucidation of an isolated phytotoxin can facilitate the development of a synthetic analogue with improved biological activity.

Details of the study have been published in the journal, Crop Protection.

Table 1: Fungal phytotoxins for potential species-specifi c biocontrolSource Phytotoxin Possible Biocontrol TargetBipolaris euphorbiae NK Euphorbia heterophylla

Alternaria cinerariae, A zinnia; Curvularia eragrostidis QZ2000

a,b -dehydrocurvularin Xanthium occidentale; Digitaria sanguinalis

Ascochyta caulina ascaulitoxin aglycone Chenopodium album

Ascochyta sonchi ascosonchine Sonchus arvensis

Fusarium moniliforme fumonisin B1 Lemna pausicostata

Fusarium spp, especially F oxysporum f sp lili fusaric acid methyl ester (5-butylpicolinic acid) Striga spp

Phyllosticta cirsii phyllosictine A Cirsium arvense

Source: Crop Protection.

Table 2: Broad-spectrum fungal phytotoxinsPhytotoxin Source MoAAnhydro-D-glucitol Fusarium solani sugar metabolism disruptor

Beticolin Cercospora beticola membrane function disruptor

B-nitroproprionic acid Septoria cirsii succinate dehydrogenase inhibitor

Cercosporin Cercospora spp photosensitiser

Cerulenin Cephalosporium cerulens lipid synthesis inhibitor

Cinnacidin Nectria spp DA060097 jasmonic acid analogue

Colletotrichin Colletotrichum spp membrane function disruptor

Cornexistin Paecilomyces variotii amino acid transferase inhibitor

Cyperin Preussia fl eischhakii; Phoma sorghina; Ascochyta cypericola

lipid synthesis inhibitor; PPO inhibitor

Cytochalasin Phoma exigua; Zygosporium masonii mitosis disruptor

Elsinochromes Elsinoe fawcetti photosensitiser

Fusicoccin Fusicoccum amygdali (Phomopsis amygdali) membrane function disruptor

Fungal phytotoxins reviewed

X www.agrow.com ©Informa UK Ltd 2013

Biopesticides

Table 2: Broad-spectrum fungal phytotoxins (continued)Phytotoxin Source MoAGliotoxin Aspergillus spp; Gliocladium fi mbriatum protein conjugator

HC toxin Cochliobolus carbonum mitosis disruptor

Hymeglusin (1233A or L-659699) Scopulariopsis spp terpenoid synthesis inhibitor

Macrocidin Phoma macrostoma terpenoid synthesis inhibitor

Moniliformin Fusarium moniliforme mitosis disruptor

Ophiobolin Bipolaris spp membrane function disruptor

Rhizobitoxine Bradyrhizobium spp methionine/ethylene synthesis inhibitor

Rubellin D Ramularia collo-cygni photosensitiser

Sirodesmin PL Leptosphaeria maculans protein conjugator

Solanapyrone A, B & C Ascochyta rabiei DNA polymerase inhibitor

Taxol Taxomyces andreanae mitosis disruptor

Tentoxin (1967) Anacystis nidulans; Alternaria alternata PPO import and chloroplast ATP synthase inhibitor

Tenuazonic acid Piricularia oryzae; Alternaria alternata PS II inhibitor

Trichothecene-2; (T-2 toxin) Cochiobolus heterstrophus, Phyllostica maydis, Bipolaris maydis

membrane function disruptor

Victorin C Cochiobolus victoriae membrane function disruptor

Source: Crop Protection; Toxins.


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Agrow Biopesticides 2013Regional Markets, Companies, Products, Patents and Regulatory Frameworks.

The biopesticides sector is estimated to be worth around $1.5 billion per annum, with an annual growth rate expected to soon reach 15%.

Biopesticides are attracting greater interest as core options in crop protection programmes, with a number of recent high pro�le acquisitions by major R&D based companies. The largest regional market for biopesticides is North America, currently accounting for around 40% of sales. Europe, Asia and Latin America, represent 25%, 20% and 10%, respectively.

This report covers all world markets, as well as regulatory de�nitions and paths for biopesticides.

The report looks in detail at: The regulatory sectors and all major industryorganisations

The key players and signi�cant acquisitions

Company pro�les and product portfolios of leading biopesticide companies

Recent patenting activities

Future growth trends and strategic developments

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X www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com XI

Biopesticides

Biopesticide patent watchHazel Blake identi� ed biopesticide and related patent applications published in 2012 and in the � rst quarter of 2013.

US granted patentsThe US Patent and Trademark O� ce granted 17 patents for various biological control agents during the period January 2012 – March 2013. Of the 18 assignees, 11 were publicly funded entities. Insecticides were the focus of seven patents, followed by fungicides (six), plant growth regulators (two), dual purpose

products (fungicide/insecticide - one) and herbicides (one). The USDA was the only assignee with more than one patent granted in the period. Its four awards included two concerning the use of di� erent strains of the Solenopsis invicta virus to control � re ants. Eight patents concerned speci� c strains of bacteria or fungi, mostly for use as fungicides.

Biopesticides

US granted biopesticide patents 2012- 13Year Assignee Patent Number Type Description

2013 Lincoln University, New Zealand

8,394,623 Fungicide Use of Trichoderma atroviride strains as a fungicide effective against Rhizoctonia spp, Sclerotinia spp, Pythium spp and Fusarium spp

2012 Adjuvants Plus, Canada 8,101,551 PGR Use of plant endophyte Clonostachys rosea strain 88-710 as a growth promoter

2012 French national centre for science research(CNRS)

8,101,171 PGR Use of synthetic analogues of strigalactones GR7 and GR24 to promote growth of arbuscular mycorrhizal fungi, especially Glomus intraradices and Gigaspora rosea

2012 Connecticut University, US 8,362,201 Insecticide Australian funnel-web spider (Hadronyche versuta) toxin, omega-atracotoxin-Hv2a, used as a foliar insecticidal spray

2012 J H Biotech, Canada 8,188,004 Herbicide Herbicidal composition comprising oxidized clove oil, eugenol, or cinnamon oil and a surfactant comprising casein, whole egg powder and Konjac glucomannan effective against broad-leaved weeds, especially docks, nettles, thistles and common ragwort

2012 Koppert, Netherlands 8,097,248 Insecticide Use of Amblyseius sirskii to control Carpoglyphus lactis, Dermatophagoides farina, Euroglyphus longior, E maynei, Pyroglyphus africanus, Glyciphagus destructor, G domesticus and Lepidoglyphus destructor

2012 Korea Research Institute of Chemical Technology

8,202,514 Fungicide Use of Bacillus subtilis strain EB120 as a fungicide

2012 Michigan State University, US 8,202,552 Insecticide Plant extract from Turkish hop (Humulus lupulus) � ower buds effective against Colorado potato beetles (Leptinotarsa decemlineata)

2012 Monaghan Mushrooms, Ireland 8,329,446 Fungicide Use of Bacillus subtilis strain J-P13 to control Trichoderma spp in mushroom production

2012 Nippon Soda 8,257,958 Fungicide Use of Pseudomonas rhodesiae FERM BP-10912 as a bactericide effective against canker, bacterial shot hole, bacterial soft rot, bacterial spot, bacterial black spot, bacterial wilt, necrotic leaf spot, pitch necrosis, bacterial grain rot, bacterial seedling blight, bacterial leaf blight, bacterial rot and black rot

2012 Rothamsted Research, UK 8,221,736 Insecticide Use of cis jasmones alpha-farnesene, beta-caryophyllene, 4,8-dimethyl-1,3,7-nonatriene or especially beta-ocimene as a semiochemical in a foliar spray in beans (Vicia faba) or wheat to elicit/prime plant defence responses, increase parasitoid foraging and reduce feeding by aphids or pollen beetles

2012 Santiago University, Chile 8,372,391 Fungicide Use of Serratia plymuthica CCGG2742, isolated from grape skins, as a fungicide effective against Botrytis cinerea

XII www.agrow.com ©Informa UK Ltd 2013

US, EP AND WTO biopesticide patent applications 2012-13Assignee Patent Number Type Description

Gottingen University, Germany US20130071425 Insecticide Use of Beauveria bassiana strain ATP02, DSM 24665 as an insecticide

INRA, France US20130071356 Fungicide Use of � lamentous algae, Phoma spp strain I-4278 as a fungicide, especially against Phytophthora parasitica

USDA; Gonzaga University, US US20130035231 Herbicide Use of Pyrenophora semeniperda to control brome grass

Biopreparáty, Czech Republic US20130035230 Fungicide Use of Pythium oligandrum as a fungicide

Synthetic Genomics/Monsanto WO/2013/016361 US20130031673

Fungicide Use of Mycosphaerella spp strain SGI-010-H11, Microbacterium spp strain SGI-014-006 or SGI-005-G08, Variovorax sp strain SGI-014-G01, Bacillus spp strain SGI-015-F03 or SGI-015-H06 to control head blight (Fusarium graminearum) in cereals

Natural Resources Canada US20130028858 Insecticide Use of (3Z)-dodecen-12-olide and ash green leaf volatiles in a light trap to control emerald ash borers (Agrilus planipennis)

BASF US20130017949 PGR Use of Penicillium bilaji as a phosphate solubiliser in fungicidal mixtures

USDA US20130014428 Insecticide Use of the semiochemical 3-methyl-2-buten-1-ol to control walnut twig beetles (Pityophthorus jugkandis)

Lantmännen Bioagri US20130005572 PGR Use of Pseudomonas azotoformans, strain F30Aas a PGR

USDA US20120322658 Fungicide/PGR Use of a co-culture of Pseudomonas fl uorescens strain NRRL B-21133, NRRL B-21053 or NRRL B-21102 or Enterobacter cloacae strain NRRL B-21050 as a fungicide, especially against Fusarium dry rot (Gibberella pulicaris), pink rot (Phytophthora erythroseptica) and late blight (Phytophthora infestans) or to suppress tuber sprouting in potatoes

US, EP and WTO applications There were 36 patent applications from 27 assignees claiming methods of biological control of plant pests and pathogens published in the 15 months to March 2013. Fungicides were the focus of 14 applications, followed by insecticides (ten), plant growth regulators (seven), dual action products (fungicide/insecticides or fungicide/PGR – two) and herbicides (one).

The most active assignee was the USDA with four � lings published. It was followed by AgraQuest (now owned by Bayer Crop Science) and BASF (three each), Australian Agriculture Victoria Services and the US California University (two each).Publicly-funded organisations accounted for two-thirds (19/27) of the applications published.

BASF’s applications include a � ling concerning the combination

of Bacillus subtilis strain QST713 and various synthetic fungicides. In 2009 BASF agreed a licensing deal for B subtilis with AgraQuest which sells the product as Serenade. AgraQuest has since been acquired by Bayer Crop Science.

Five applications concerned the control of speci� c pathogens. These included a bacterial inoculant e� ective against Xylella fastidiosa, the causative agent of Pierce’s disease from California University; a seedling treatment for the prevention of white pine blister rust (Cronartium ribicola) and anther-smut (Microbotryum violaceum – JD Irving); a nematicide e� ective against lance nematodes (Hoplolaimus magnistylus – Pasteuria BioScience); the use of Pseudomonas � uorescens VP5 to control red root disease (Poria hypolateritia) in tea (Rangasamy College of Technology, India); and the use of the fungus, Pyrenophora semeniperda, to control annual brome grass (USDA and Gonzaga University).

continued on page XIV . . .

Biopesticides

US granted biopesticide patents 2012- 13 (continued)

Year Assignee Patent Number Type Description

2012 Santiago University, Chile 8,372,391 Fungicide Use of Serratia plymuthica CCGG2742, isolated from grape skins, as a fungicide effective against Botrytis cinerea

2012 USDA 8,226,938 Insecticide Use of Beauveria bassiana strain NRRL 30976 used as an acaricide against Varroa destructor in honeybee colonies

2012 USDA 8,183,025 Insecticide Solenopsis invicta virus (SINV2) as a biocontrol of � re ants

2012 USDA 8,101,172 Insecticide Solenopsis invicta virus (SINV3) as a biocontrol of � re ants

2012 USDA, Ohio State University, US

8,257,958 Fungicide Use of prothioconazole-tolerant Cryptococcus fl avescens strain OH 182.9 as a fungicide effective against Fusarium graminearum

2012 Valent BioSciences 8,273,389 Fungicide/ Nematicide

Composition containing diallyl disul� de and cinnamon oil and/or cinnamaldehyde for use on cucumbers, melons and tomatoes as: a fungicide effective against Pythium spp, Rhoxoctonia spp and Sclerotinia; or a nematicide effective against root knot nematodes (Meloidogyne incognita)

XII www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com XIII

With the global industry recognising the growing importance in the role of biopesticides as part of ICM, EAS Group is the ideal partner for all of your product development needs.

EAS Group can advise and support your biopesticide development program, providing the trials and analytical services needed for the registration of your product.

Working together for a sustainable future.

Our expertise includes:

• Greenhouseefficacyscreening• Laboratoryefficacyscreening• Regulatoryefficacystudiesfor local, international and global submissions• Regulatory GLP ecotoxicology studies• Regulatory product chemistry studies

www.eurofins.com/[email protected]

Biopesticide Services

US, EP AND WTO biopesticide patent applications 2012-13 (continued)Assignee Patent Number Type Description

California University, US US20120282233 Fungicide Use of Achromobacter spp or Geomyces spp as a bactericide xylem inoculant effective against Xylella fastidiosa

Rangasamy College of Technology, India

US20120270735 Fungicide Use of Pseudomonas fl uorescens VP5 to control red root disease (Poria hypolateritia) in tea

AgraQuest US20120231951 Fungicide Use of Bacillus subtilis strains QST30002 and QST3004 (NRRL B-50421 and NRRL B-50455) sandpaper mutants as a bactericide/fungicide

California University, US US20120201981 Insecticide Use of Bacillus fi rmus as a nematicide, especially in seed coatings

JD Irving, Canada US20120198590 Fungicide Use of Pinus strobus endophytes as a fungicide, especially against Cronartium ribicola, and/or Microbotryum violaceum

Bio Insumos Nativa Limitada, Chile US20120183517 Fungicide Use of Brevibacillus parabrevis strain No 4; Bacillus subtilis strain No 5; Bacillus cereus strain No 6 and B cereus strain No 7 as a plant protectant/bactericide, especially against Pseudomonas spp

USDA US20120183507 Fungicide Use of non-toxigenic Aspergillus strains NRRL 50427, NRRL 50428, NRRL 50429, NRRL 50430 and NRRL 50431 to control A fl avus in maize, peanuts and tree nuts

Wisconsin University, US US20120164105 Insecticide Use of Bacillus thuringiensis subsp kurstaki strain VBTS 2477 quadruple enterotoxin-de� cient mutants as an insecticide

Saskatchewan University, Canada US20120156173 WO/2011/022809; WO/2012/113051

Fungicide Use of Sphaerodes mycoparasitica strains IDAC 301008-01, -02, or -03, as a fungicide, especially against Fusarium spp

TERI, India US20120128648 Insecticide Use of Eucalyptus camaldulensis or E globus extracts as insecticides

AgraQuest US20120114610 Fungicide Use of Muscodor albus strain NRRL 30547 or NRRL30548 as a bactericide

Santiago University, Chile US20120107280 Fungicide Use of Serratia plymuthica CCGG2742 as a fungicide

BASF US20120094834 PGR Use of Bacillus subtilis strain NRRL B-21661 as a PGR

Bayer US20120077673 Fungicide/Insecticide

Use of a fungicidal xylylalanine and Chenopodium quinoa saponin extract to induce systemic acquired resistance in plants

USDA US20120076765 Fungicide Use of Bacillus simplex strains 03WN13, 03WN23 and 03WN25, Pseudomonas koreensis strain 10IL21 and P lini strain 13IL01, and or Pantoea agglomerans strain 10IL31 as a fungicide, especially against pink rot (Phytophthora erythroseptica) in potatoes

Agscitech US20120058895 Insecticide Use of glycolipid biosurfactants derived from Pseudomonas aeruginosa, P putida, P fl orescens, P fragi or P syringae; Flavobacterium spp; Candida albicans, C rugosa, C tropicalis, C lipolytica or C torulopsis; Rhodococcus spp; Arthrobacter spp; Campylobacter spp or Cornybacterium spp as insecticides

BioWorks US20120028799 Fungicide Use of Streptomyces scopuliridis strain RB72 to control bacterial and fungal diseases in plants

Bee Vectoring Technology US20120021906 PGR Use of Clonostachys rosea, Trichoderma harzianum, T koningii, T virens, Paecilomyces lilacinus, Ulocladium atrum, Penicillium oxalicum, Penicillium bilai, and/or Fusarium oxysporum as PGR

BASF US20120003199 Fungicide Use of Bacillus subtilis strain QST 713 as a fungicide

AgraQuest US20120003197 PGR Use of Bacillus mycoides isolate BmJ NRRL B-30890 to induce systemic acquired resistance in plants

Agriculture Victoria Services, Australia WO/2012/159161 PGR Use of Nodulisporium spp, Ascocoryne sarcoides or Coryne spp extracts as PGR

Agriculture Victoria Services, Australia WO/2012/174585 PGR Use of Acremonium spp endophytes derived from the Brachiaria spp - Urochloa spp complex as a PGR

Chr Hansen WO/2012/020014 Insecticide Use of Bacillus subtilis strain DSM 17231 and B licheniformis strain DSM17236 as a nematicide

CNRS, France WO/2013/011142 EP2012/064357

Fungicide Use of Streptomyces spp BG76 strain as a fungicide effective against Pythium ultimum, and as a phosphate solubiliser

Czech Academy of Sciences WO/2010/006563 Insecticide Use of Isaria fumosorosea CCM 8367 (CCEFO.011.PFR) as an insecticide

Pasteuria Bioscience WO/2012/064527 insecticide Use of Pasteuria strain ATCC SD-5832 as a nematicide effective against lance nematodes (Hoplolaimus magnistylu)

Patent Watch continued from page XIII

XIV www.agrow.com ©Informa UK Ltd 2013

Biopesticides

With the global industry recognising the growing importance in the role of biopesticides as part of ICM, EAS Group is the ideal partner for all of your product development needs.

EAS Group can advise and support your biopesticide development program, providing the trials and analytical services needed for the registration of your product.

Working together for a sustainable future.

Our expertise includes:

• Greenhouseefficacyscreening• Laboratoryefficacyscreening• Regulatoryefficacystudiesfor local, international and global submissions• Regulatory GLP ecotoxicology studies• Regulatory product chemistry studies

www.eurofins.com/[email protected]

Biopesticide Services

Biopesticide Development in ChinaAgrow’s guest author Shuyou Han traces the development and prospects of biopesticides in China

The Chinese Ministry of Agriculture’s Institute for the Control of Agrochemicals (ICAMA) has not developed a speci� c de� nition of biopesticides. The prevalent description of the category is in line with the ones developed by the UN FAO and the US EPA. The ICAMA’s required documentation for biopesticides is partially waived and is much less than that for synthetic pesticides. Chinese biopesticide research groups agree that biopesticides include microbial pesticides, agricultural antibiotics, botanical pesticides, biochemical pesticides, predatory insects, and plant-incorporated protectants (PIPs) in the form of genetically modi� ed crops.

China started biopesticide research in the 1950s. The main products are grouped under the following categories: 1) microbial insecticides (Bt, Beauveria bassiana, NPVs); 2) agricultural antibiotics (Jinggangmycin, abamectin); 3) botanical pesticides (rotenone, toosedarin); 4) biochemical pesticides (PGRs, insect hormones); 5) PIPs; 6) predatory insects.

Statistics from the national agriculture technical extension centre showed that biopesticide treated acreage was around 33-40 million ha annually, accounting for around 8% of total pesticide treated area. It is planned that the biopesticide share should be expanded to 30% in 2015. Among the biopesticides used, 88% were microbials and agricultural antibiotics.

Until the end of 2010, there were 73 registered biopesticide active ingredients. The number of � nished products was 2,500, accounting for 11.2% of the entire registered pesticide ais (650), and 9.3% of the total number of � nished products (27,000). ICAMA statistics indicate that there are currently more than 200 microbial, botanical and biochemical biopesticide manufacturers, and ten of them are thought to be large-scale enterprises. Interestingly, the number of agriculture antibiotic producers exceeds 1,700 in China.

The number of registered biopesticide ais moved up to 85 in 2011, a third of which were insecticides, and nearly two-thirds were fungicides. In 2011, the import and export volume of biopesticides was 3.27 million tonnes (formulated products), accounting for 2.2% of the entire pesticide trade. The import and export value of biopesticides was $173 million, making up 2.6% of the total. Exports amounted to 32,300 tonnes ($162 million), accounting for 10% of total global biopesticide sales. The largest exported biopesticide was abamectin, followed by Bt. The major target countries

(and regions) were the EU, US, Argentina, Colombia, Uruguay, Brazil, Japan, South Africa, and Pakistan. Annual production of pyrethrin products reached 5,000 tonnes, accounting for 25% of the international market in recent years.

In terms of sales volumes and revenue, abamectin is followed by Jinggangmycin, gibberellin, and Bt. In terms of application by area, Jinggangmycin takes the lead, followed by abamectin, Bt and gibberellin.

Main biopesticides in China

1. Microbial pesticides

Among 25 registered microbial pesticides ais, nine are bacteria, seven are fungi, and nine are viruses.

Table 1. Microbial and viral biopesticides used in ChinaNames of microbes Total No of

registrationsTotal No of

manufacturersPesticide

type

Bacillus thuringiensis 132 85 insecticide

Bacillus cereus 4 4 fungicide

Bacillus subtilis 11 8 fungicide

Bacillus licheniformis 1 1 fungicide

Paecilomyces lilacinus 6 3 nematicide

Verticillium chlamydosporium ZK7

2 1 nematicide

Paenibacillus polymyza 3 1 fungicide

Trichoderma spp 5 2 fungicide

Conidioblous thromboide 1 1 fungicide

Bacillus sphaericus H5a5b 3 2 insecticide

Pseudomonas fl uorescens 2 1 fungicide

Beauveria bassiana 7 1 insecticide

Metarhizium anisopliae 7 3 insecticide

Pierisrapae granulosis virus (GV)

2 1 insecticide

Ectropis obliqua Nuclear polyhedrois virus (NPV)

2 1 insecticide

Heliothis armigera NPV 19 11 insecticide

Dendrolimus punctatus cytoplasmic polyhedrosis virus

2 2 insecticide

Laphygma exigua NPV 5 2 insecticide

Autographa californica NPV 2 1 insecticide

Plutella xylostella GV 1 1 insecticide

Spodoptera litura NPV 3 1 insecticide

Periplaneta fuliginosa densovirus

1 1 insecticide

XVI www.agrow.com ©Informa UK Ltd 2013

Biopesticides

Microbial pesticides make up one of the largest groups in biopesticides, involving around 300 products. The largest sub-group of microbial pesticides is Bt, comprising 167 products. The most used Bt formulations in China are wettable powders (WP) and suspension concentrates (SC).

China also has achieved progress in microbial fungicides and insecticides. There has been active research and application of Bacillus spp as biofungicides. B subtilis has been used to control rice blast, vegetable grey mould, powdery mildew, and B cereu is used against rice blast, rice false smut and rice sheath blight in China. B bassiana has been widely used to control long-horned beetle (Anoplophora glabripennis), Micromelalopha troglodyte, pin moth, and fall webworm (Hyphantria cunea). The registration of viral pesticides has increased signi� cantly, with some 19 products, mainly in WP and SC formulations. For instance, Heliothis armigera NPV has been well accepted to control cotton bollworms. Sporozoans have been used to target control of grasshoppers.

2. Agricultural antibiotics

There are 13 registered agricultural antibiotic ais in China and there are around 1,700 products containing these ais. Abamectin is the leading ai and there are 1,220 products based on it. The main formulations are EC, WP, microencapsulations (ME) and emulsions in water (EW). The second most important ai is Jinggangmycin, of which 300 products have been registered. The main formulations of are WP and SC. Jinggangmycin has been used against rice sheath blight since the 1970s, and some 35,000 tonnes (formulation) are used annually on 10-13 million ha on rice. It has had some resistance issues recently and polyoxin has been gradually replacing Jinggangmycin due to its lower cost, higher e� cacy and broader spectrum. Polyoxin has estimated sales of around $160 million.

Table 2. Agricultural antibiotics registered in China Names of microbes Total No of


manufacturersPesticide type

abamectin or avermectin (inluding abamectin-aminomethyl)

1,005 482 insecticide

spinosad 16 9 insecticide

Jinggangmycin 160 92 fungicide

kasugamycin 56 40 fungicide

polyoxin 65 44 fungicide

cytosinpeptidemycin 2 1 fungicide

ningnanmycin 4 1 fungicide

streptomycin sulfate 6 4 fungicide

phenazino-1-carboxylic 3 2 fungicide

tetramycin 2 1 fungicide

Ruo Du Suo Jun Du Su 3 2 rodenticide

China has patented dozens of agricultural antibiotics since the 1990s, including jietacin, meilingmycin, ningnanmycin, polarmycin, yimeijunsu, men-myco-93-63 and wanlongmycin. Ningnanmycin and zhongshengmycin are in the initial stages of commercialisation.

3. Botanical pesticides

China has carried out botanical pesticide research since the 1930s. In the higher plants, those of the Compositae family were found to have insecticidal and fungicidal activities. Meliaceae plants have proven to be repellent and have anti-feedant e� ects on harmful insects. Celastraceae plant extracts control insects on rice, maize and vegetables. Selaginellaceae and Thymelaeaceae plants are other hot spots for biopesticide research. The botanical pesticides can be classi� ed chemically as follows:

Alkaloids: nicotine, matrine, coptisine, wilfordine, stemonine, capsaicin, veratridine Terpenes: azadirachtin, toosendanin, tea saponin, celangulin Naphthoquinones and � avonoids: oxymatrine, rotenone, elliptinone Volatile oils: daisy oil, peppermint oil, cinnamon oilLight activated toxin class: wormwood diyneCarboxylic esters: pyrethrin Steroidal: sterone, ecdysterone

Some 17 botanical pesticides and over 200 products have been registered. The main formulation is aqeous solution (AS). The most registered product is matrine (54 products), followed by brassinolide (35 products).

Table 3. Botanical pesticides registered in ChinaBotanical pesticides No of

registrationNo of


matrine 60 47 insecticide/fungicide

eugenol 4 4 fungicide

azadirachtin 15 9 insecticide

rotenone 14 10 insecticide

pyrethrins 9 5 insecticide

cnidiadin 4 2 insecticide/fungicide

vertrine 4 3 insecticide

nicotine 7 6 insecticide

Celastrus angulatus 2 1 insecticide

camphor (d-camphor) 5 5 insecticide

curcumol 2 1 rodenticide

Da Huang Su Jia Mi 2 1 fungicide

eucalyptol 2 2 insecticide

carvacrol 1 1 fungicide

ethylicin 19 14 fungicide

continued on page XVIII . . .

XVI www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com XVII

Biopesticides

4. Biochemical pesticides

Biochemical pesticides are naturally occurring substances that control pests by non-toxic mechanisms. Biochemical pesticides include substances, such as pheromones, which interfere with mating, as well as various scented plant extracts that attract insect pests to traps. The application acreage is around 6 million ha annually.

Table 4. Biochemical pesticides registered in ChinaBiochemical pesticides Total No of



cyromazine 45 31 insect growth regulator

Yi Shi Jing 9 7 insect growth regulator

chlorbenzuron 35 23 insect growth regulator

di� ubenzuron 37 26 insect growth regulator

hexa� umuron 87 75 insect growth regulator

trimedlure 1 1 insect attractant

torula yeast 1 1 insect attractant

Z-8-dodecen-1-yl acetate, Z-8-dodecen-1-ol, E-8-dodecen-1-yl acetate

2 1 sex pheromone

muscalure 2 2 insect attractant

gibberellic acid 74 33 PGR

4-indol-3-yl butyric acid 5 5 PGR

indol-3-yl acetic acid 3 3 PGR

ethephon 91 72 PGR

triacontanol 11 8 PGR

oxyenadenine 3 1 PGR

6-benzylamino-purine 8 4 PGR

oligosaccharins 14 13 fungicide/PGR

fungal proteoglycan 15 11 fungicide

Chitosan 4 4 Plant induced resistance

agent/PGR

oligosaccharins (Pu Jv Xi Tang)

2 1 fungicide

oligosaccharins 2 2 Plant induced resistance

agent/fungicide

harpin protein 2 2 PGR


Biopesticides of animal origin can be classi� ed into the following categories: insect endogenous hormone, ecdysone, pheromone, and repellent. Until now, thousands of juvenile hormones have been synthesised, but only

XVIII www.agrow.com ©Informa UK Ltd 2013
















1.

2.

3.

4.



. . . China continued from page XVII methoprene, Meng -512 and fenoxycarb have been registered and commercialised. There have so far been no reports that repellents can be applied to agriculture.

Six ais and around 100 products have been registered in China, the most important being gibberellic acid. Pheromone-based products have developed rapidly due to their low dosage, no pollution and environmentally friendly formulations.

5. Predatory insects

Research has been under way since the 1970s on the successful mechanised production of arti� cial eggs of Trichogramma dendrolimi and Anastatus japonicas. T dendrolimi is used to control corn borers and sugar cane borers, covering 500,000-600,000 ha annually. A japonicas is used against Tessaratoma papillosa Drury on some 800,000 ha. In recent years, Amblyseius cucumeris was reared and successfully employed to control leaf mites in Fujian, Guangdong, and Xinjiang. It will be registered and commercialised soon. Hebei Plant Protection Institute used Microplitis mediator to control cotton bollworm (second generation) with e� cacy of higher than 76%. It is expected that more and more natural enemies will be used as IPM tools in the future.

Table 5 Predatory insects registered in China Predatory insects Total No of

registrationsTotal No of manufacturers

Pesticide types

Trichogramma dendrolimi matsumura

1 3 insecticide

Anastatus japonicas 1 1 insecticide

Outlook

There are more than 30 biopesticide research institutes with 20,000 researchers exploring opportunities in biopesticides in China. Combining strain breeding and improved fermentation technologies, Chinese researchers have increased abamectin fermentation e� ciency by over 30 times, while the productivity of agricultural antibiotic 120 and Bt have been enhanced by three times and � ve times, respectively. The production cost has been cut by 5-25% by optimised processing and formulation improvement.

The Syngenta natural products innovation centre has been recently set up in Optics Valley, Wuhan. It was jointly built by Hubei Academy of Agricultural National Biopesticide Engineering Research Center and Syngenta. This is the � rst Sino-foreign natural product innovation centre. Both sides will be devoted to creating microbial pesticides and other leading compounds, providing a platform of biopesticide R&D with the aim of improving biopesticide research facilities in China.

Biopesticides

4. Biochemical pesticides

Biochemical pesticides are naturally occurring substances that control pests by non-toxic mechanisms. Biochemical pesticides include substances, such as pheromones, which interfere with mating, as well as various scented plant extracts that attract insect pests to traps. The application acreage is around 6 million ha annually.

Table 4. Biochemical pesticides registered in ChinaBiochemical pesticides Total No of



cyromazine 45 31 insect growth regulator

Yi Shi Jing 9 7 insect growth regulator

chlorbenzuron 35 23 insect growth regulator

di� ubenzuron 37 26 insect growth regulator

hexa� umuron 87 75 insect growth regulator

trimedlure 1 1 insect attractant

torula yeast 1 1 insect attractant

Z-8-dodecen-1-yl acetate, Z-8-dodecen-1-ol, E-8-dodecen-1-yl acetate

2 1 sex pheromone

muscalure 2 2 insect attractant

gibberellic acid 74 33 PGR

4-indol-3-yl butyric acid 5 5 PGR

indol-3-yl acetic acid 3 3 PGR

ethephon 91 72 PGR

triacontanol 11 8 PGR

oxyenadenine 3 1 PGR

6-benzylamino-purine 8 4 PGR

oligosaccharins 14 13 fungicide/PGR

fungal proteoglycan 15 11 fungicide

Chitosan 4 4 Plant induced resistance

agent/PGR

oligosaccharins (Pu Jv Xi Tang)

2 1 fungicide

oligosaccharins 2 2 Plant induced resistance

agent/fungicide

harpin protein 2 2 PGR


Biopesticides of animal origin can be classi� ed into the following categories: insect endogenous hormone, ecdysone, pheromone, and repellent. Until now, thousands of juvenile hormones have been synthesised, but only

XVIII www.agrow.com ©Informa UK Ltd 2013
















1.

2.

3.

4.



. . . China continued from page XVII methoprene, Meng -512 and fenoxycarb have been registered and commercialised. There have so far been no reports that repellents can be applied to agriculture.

Six ais and around 100 products have been registered in China, the most important being gibberellic acid. Pheromone-based products have developed rapidly due to their low dosage, no pollution and environmentally friendly formulations.

5. Predatory insects

Research has been under way since the 1970s on the successful mechanised production of arti� cial eggs of Trichogramma dendrolimi and Anastatus japonicas. T dendrolimi is used to control corn borers and sugar cane borers, covering 500,000-600,000 ha annually. A japonicas is used against Tessaratoma papillosa Drury on some 800,000 ha. In recent years, Amblyseius cucumeris was reared and successfully employed to control leaf mites in Fujian, Guangdong, and Xinjiang. It will be registered and commercialised soon. Hebei Plant Protection Institute used Microplitis mediator to control cotton bollworm (second generation) with e� cacy of higher than 76%. It is expected that more and more natural enemies will be used as IPM tools in the future.

Table 5 Predatory insects registered in China Predatory insects Total No of

registrationsTotal No of manufacturers

Pesticide types

Trichogramma dendrolimi matsumura

1 3 insecticide

Anastatus japonicas 1 1 insecticide

Outlook

There are more than 30 biopesticide research institutes with 20,000 researchers exploring opportunities in biopesticides in China. Combining strain breeding and improved fermentation technologies, Chinese researchers have increased abamectin fermentation e� ciency by over 30 times, while the productivity of agricultural antibiotic 120 and Bt have been enhanced by three times and � ve times, respectively. The production cost has been cut by 5-25% by optimised processing and formulation improvement.

The Syngenta natural products innovation centre has been recently set up in Optics Valley, Wuhan. It was jointly built by Hubei Academy of Agricultural National Biopesticide Engineering Research Center and Syngenta. This is the � rst Sino-foreign natural product innovation centre. Both sides will be devoted to creating microbial pesticides and other leading compounds, providing a platform of biopesticide R&D with the aim of improving biopesticide research facilities in China.

Biopesticides

LKC PROVIDES SCIENTIFIC AND REGULATORY ADVICE TO THE BIOPESTICIDE SECTOR

LKC have been active in Crop Protection and Biocide Regulatory areas for over 10 years. We have been successful in registering new actives as well as maintaining registrations within the complex

European Market.

We have experience with EU Regulations concerning Biopesticides including Pheromones, Semiochemicals, Microbial pest control agents, plant extracts, essential oils and fertilizers.

We are supporting IBMA (International Biocontrol Manufacturers Association) to ensure the best regulatory practices are being adopted in the European Community.

LKC provide the following Services that can help you to benefit in the European Markets:

Advantage of a dedicated expert scientific team for the European registration of Biopesticides as active ingredients and the national registrations of their formulated products, label extensions, import tolerance setting and harmonization of labels;

Expertise in developing innovative regulatory strategies for companies including cost saving methods e.g. literature searches, data review, technical justifications, expert statements and scientific data waivers to balance economic and registration requirements;

Planning and Management of regulatory studies and preparing parts or whole registration dossiers including risk assessments.

If you are looking for support to register your Biopesticides in Europe, contact:

LKC Switzerland Ltd

4414 Füllinsdorf

Switzerland


Web: www.LKC-ltd.com

Agrow’s

China Special(in collaboration with the CCPIA)

Contact: Leah Lee


Tel: 86-10-84885907

Fax: 86-10-84885907

Web: www.agrochemex.org

China Crop Protection Industry Association, founded in 1982, is one of the earliest & leading industrial associations in China. The association runs a membership form, now it has 480 members, including technical manufacturers, formulators and related affiliated companies. CCPIA’s members have become a major force in China’s crop protection industry, contributing at least 90% production output in China.

Objectives:

Provide services for the government, the agrochemical industry, and the agro-chemical companies in the form of a bridge between the government and the industry for the sustainable and healthy development of agrochemical industry.

Main Functions:

1. Issuing Production License for

Agrochemicals in China, this is

entrusted by Ministry of Industry

and Information Technology of

China (MIIT).

2. Questioning the inappropriate

enforcement and practices from

government’s sectors on behalf of

members.

3. Participating in the revisions of

important policies.

4. Establishing agchem consortiums to

constrain the disorder competition &

obtain certain objectives.

5. Organizing the annual agrochemical

symposium and exhibition

AgroChemEx.

TRUSTCHEM CO., LTD

23rd Floor Golden Eagle International Plaza 89 Hanzhong Rd Nanjing, 210029, China

Tel: 0086-25-84729803 Fax: 0086-25-84725172

Website: www.trustchem.com www.trustsurfactant-china.com


Contact: Susan Dee

TRUSTCHEM Group, since it’s

established, follows the strategy

that“R&D, Production and

Marketing”accompanied by our

principle “Honest, Truth and

Trust”. During the past fifteen

years of continuing efforts, our

Group has grown to an influential

corporation,specialized in Fine

Chemical Industry in CHINA.

Now we can produce Technical

with annual output 3000MT

and Formulation with annual

output 10,000MT which include

WDG,WS,WP,SC,FC,SL,EC,EW,OD

etc.

TRUSTCHEM will continuously

serve its worldwide customers

with high-quality, competitive

price with on-time delivery.

Trustchem is fully compliance

with all the local and national

S&HE regulations.

Trusthem produces a wide

range of surfactant products

based on its extensive

technology and production

capabilities, products including,

Surfactant, Emulsifier and wetting

agents, used on all type of

formulations.

Table 2: Broad-spectrum fungal phytotoxins (continued)Phytotoxin Source MoAGliotoxin Aspergillus spp; Gliocladium fi mbriatum protein conjugator

HC toxin Cochliobolus carbonum mitosis disruptor

Hymeglusin (1233A or L-659699) Scopulariopsis spp terpenoid synthesis inhibitor

Macrocidin Phoma macrostoma terpenoid synthesis inhibitor

Moniliformin Fusarium moniliforme mitosis disruptor

Ophiobolin Bipolaris spp membrane function disruptor

Rhizobitoxine Bradyrhizobium spp methionine/ethylene synthesis inhibitor

Rubellin D Ramularia collo-cygni photosensitiser

Sirodesmin PL Leptosphaeria maculans protein conjugator

Solanapyrone A, B & C Ascochyta rabiei DNA polymerase inhibitor

Taxol Taxomyces andreanae mitosis disruptor

Tentoxin (1967) Anacystis nidulans; Alternaria alternata PPO import and chloroplast ATP synthase inhibitor

Tenuazonic acid Piricularia oryzae; Alternaria alternata PS II inhibitor

Trichothecene-2; (T-2 toxin) Cochiobolus heterstrophus, Phyllostica maydis, Bipolaris maydis

membrane function disruptor

Victorin C Cochiobolus victoriae membrane function disruptor

Source: Crop Protection; Toxins.


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1.

2.

3.

4.

The regulatory sectors and all major industryorganisations



Company pro�les and product portfolios of leading biopesticide companiesCompany pro�les and product portfolios of leading


Future growth trends and strategic developmentsFuture growth trends and strategic developments


[email protected] +44 20 7017 4308















4 reasons why you


1.

2.

3.

4.



X www.agrow.com ©Informa UK Ltd 2013 ©Informa UK Ltd 2013 www.agrow.com XI

Biopesticides

Jiangsu Fengshan Group Co., Ltd

Factory:

Caomiao Town Dafeng City Jiangsu Province China

Nanjing office: 1903 Central International Plaza 105-6 North Zhongshan Road Nanjing, China

CONTACT:

Jiangsu Fengshan Group Co Ltd

Tel: +86-25 8655 8671

Fax: +86-25 8655 8673


Web: www.fschem.com

As an ISO9001:2000 Certified, ISO14001:1996 and OHSMS Certified company, Fengshan Group focus on agrochemicals for 25 year’s.

Jiangsu Fengshan Group Co Ltd is one of the leading agrochemical manufacturer and exporter in China, especially strong on R&D on pesticides.

Our pesticides products gained great popularity in market domestically and globally.

Technicals! Formulations! Herbicides! Insecticides! Fungicides! WP, WDG, SL, SC, SP, EC, PP and Mixtures!

Quizalofop-P-ethyl! Nicosulfuron! Trifluralin! and Glyphosate!

Propargite! Imidacloprid! Acetamiprid! and Chlorpyrifos!

Hebei BestarAddress: Floor 11 45 South Tangu Street Shijiazuang Hebei PR China

Zip: 050000

CONTACT:

Sales Dept: +86 311 8508 8998, 8508 1806

Registration dept: +86 311 8508 8989

Fax: +86 311 8508 1805

Web: http://www.bestarchem.com

E-mail: [email protected]

As a basic manufacturer located in standard chemical zone, BESTAR is well-respected for its range of quality products and for the provision on innovation and competitive cost.

We have 49 ICAMA registrations in China already and another 35 new ICAMA is under process. For technical products, our annual capacity is as follows:

Imidaclopird 3000 tons

Acetamiprid 1000 tons

Glufosineate 200 tons (1000 tons from Nov)

Chlorfenapyr 300 tons

Fipronil 300 tons

Spirodiclofen 300 tons

We can supply GLP data for above products and some other new products that patent will be over in next 2 years.

With background of real estate, we can give financial support on agrochemical business.

R

R

ISO9001,ISO14001 &

OHSAS18001 Accredited

Jiangyin Suli Chemical Co.,Ltd.

Taizhou Bailly Chemical Co.,Ltd.

CONTACT:[email protected]

[email protected]

Tel: +86-510-86636238

Fax:+86-510-86636221

Website: www.suli.com

SULI, founded in 1990, is an enterprise well-

known fo r serv ing a por t fo l io o f f ine chemicals. The company is focused on the research , p roduct ion , reg is t ra t ion and marketing series of Agrochemicals, Flame Retardant, Pharmaceutical Raw Materials, C h e m i c a l I n t e r m e d i a t e s a n d C u s t o m Chemicals with brand “SULI”. Now SULI p o s s e s s e s w h o l l y - o w n e d s u b s i d i a r i e s Jiangyin Suli Chemical Co.,Ltd., Taizhou Bailly Chemical Co.,Ltd. , Okeanos Tech Jiangsu Co.,Ltd. , and one subsidiary focusing on R & D established in Zhangjiang Hi-tech Park in Shanghai.

SULI has become the world's second largest

manufacturer for Chlorothalonil and the wor ld 's th i rd la rges t manufac turer fo r Decabromodiphenyl Ethane relying on the three core technologies of Bromination, Ammoxidation and Gas Phase Chlorination. The company has spread its business in more than 60 countries and areas all over the world and has been regarded as the strategic cooperat ion partner by lots of famous multinational agrochemical companies. SULI also maintains good cooperation with several international GLP laboratories. In the year 2012, the company achieved total sales of RMB900 mill ion with import and export amount of US$100 million. For the time being, SULI has already possessed fixed assets over RMB200 million, over 600 employees, 23% of them are superior technicians

in different aspects. and

administrators

SULI i s ac t i ve l y imp lemen t ing c lean

production of fine chemicals and keeping on regarding Safety, Environment Protection and Hea l thy as the c r i t i ca l po in t s du r i ng company 's deve lopment . SULI a lways advocates developing green chemistry and regards it as one of the social responsibilities o f t h e c o m p a n y. T h e c o m p a n y h a s undertaken lots of activities in many fields and been honored as Member units of Chinese Pesticide Industrial Association, Chinese F lame Retardant Assoc ia t ion, C h i n e s e A s s o c i a t i o n o f P e s t i c i d e Development and Appl ica t ion, J iangsu Adananced-tech Enterprise, Jiangsu Non-State-Run Sci-Tech Enterprise, National Specified Pesticide Production Enterprise and Jiangsu work station of academicians. In 2011, "SULI" brand was awarded CHINESE FAMOUS TRADEMARK, passed again the certif ication of ISO9001, ISO14001 and OSHAS18001. In 2012, SULI has been recognized by the national authority as 2012 C H I N A P E S T I C I D E H U N D R E D ENTERPRISES again, and SULI-brand Chlorothalonil was awarded with title of famous brand by China Petroleum and Chemical Society.

Add: No.7, Runhua Road, Ligang Town,

Jiangyin City, Jiangsu Province,

214444, P.R. China

Max (Rudong) Chemicals Co., Ltd

Head Office: 603 Binkang Road Hangzhou Zhejiang Province 310052 PR China

Tel: +86-571-28007880 Fax: +86-571-28007821

Email: [email protected]; [email protected]

Web: www.maxchemicals.com

An Innovative Basic Manufacturer

One-Stop Solution Provider

Problem solver

Company profile:

Established in 2000

One R&D institute. Two manufacturing sites.

35 hectares land

550 employees including 150 chemists and engineers

We are specialized in:

1) R&D: 2000 well-equipped lab, 70 experienced chemists/engineers, 7 innovative bench teams, 3 formulation teams, 1 chemical engineering design team.

2) QC : Batch-to-batch QC from raw materials, via intermediates, to finish products

3) Registration: Register source of more

than 21 product in US EPA

4) Toll manufacturing

Our production capacities:

Sulfentrazone, 600MT/a

Carfentrazone,300MT/a

Trinexapac-ethyl, 300MT/a

Chlorpropham, 500MT/a

Prodiamine, 1200MT/a

Thidiazuron, 300MT/a

Triclopyr, 1500MT/a

Dithiophy, 100MT/a

Metalaxyl, 500MT/a

Captan/Folpet,2000MT/a

Clomazone, 500MT/a

Limin Chemical Co., LtdEconomic Development Zone Xinyi Jiangsu 221400 China

Contact: Ameya Li

Tel: 0086-25-88980134

Fax: 0086-25-83246229

Email: ameya@chinalimin

Web: www.chinalimin.com

Limin Chemical Co., Ltd is a state appointed large-scale agrochemical manufacturer in China.

Limin upholds the core value “we will return the profit we get to people” and the management aim at “relying on technology and management progress, moulding the good quality of the products and services to promote the development of plant protection science and technology”. Mainly focused on agricultural fungicide research and development, production and sales.

Limin has two production bases - Xinyi Economic development zone plant & Tangdian Chemical park plant, a provincial-scale R&D center, a provincial-scale post-doctoral research station, a wholly-owned subsidiary company –Limin chemical Co., Ltd Nanjing Branch, a holding subsidiary - Tanzania, Link Forward Company Ltd, and two joint stock subsidiaries - Jingsu Xinhe Agriculture

Co., Ltd. & Jingsu Xinyi Taihe Chemical Co., Ltd..

Our main tech products and annual capacities are: 25,000MT Mancozeb, 5000MT Chlorothalonil, 2,000MT Cymoxanil, 5,000MT Propineb, 500MT Pyrimethanil, 5,000MT Foestyl-al, 500MT Difenoconazole, 100Mt Propiconazole, 500MT Azoxystrobin, 500MT Thiacloprid, 500MT Mesotrione, and so on. The formulated annual capacities 150,000MT. Our products go to more than 70 countries and regions in the world.

Limin makes a significant contribution to the crop protection with the excellent quality of the products. We also pay great attention to the health and safety of environment. We formally passed through ISO9001, ISO14001 and OHSAS18001 etc System Certification . Our tenet is "to serve agriculture, serve country, serve famers." We are glad to cooperate with every customer home and abroad to build a beautiful home.

Shandong Weifang Rainbow Co., Ltd

Address: 6th Floor Gaoxinjishuchuangye Center Shunhua Road 750# Jinan Shandong China 250101

Plant Address: Binhai Economic Development Area Weifang City Shandong Province

Tel: +86-531-88875230, 88875231, 88875227

Fax: +86-531-88875232, 88875224


Web: www.rainbowchem.com

Rainbow Chemical is one of the biggest agrochemical producers and suppliers in China, with its strategic management and operation headquarters in Jinan City, Shandong province, and its R&D center and manufacturing base in Binhai Economic Development Area, Weifang City, Shandong Province.

As an ICAMA and EPA approved basic Chinese agrochemical producer, Rainbow provides agrochemical products and related services to customers all over the world.

To guarantee all the products and services, Rainbow Chemical has been certified with ISO9001:2008, ISO14001:2004 and OHSAS 18001:2001.

There are three business segments for Rainbow Chemical:

• Basic agrochemical producer for many active ingredients.

• World class formulator and re-packer for all kinds of agrochemical formulations.

• Trader for all kinds of agrochemical products and services.

Rainbow’s Advantage:

Basic Producer & Leading Exporter in China.

Global Marketing Access Platform.

Market Driven Innovation.

Forward Thinking & Fast Response.

Delivers added Value for Partners.

Nanjing Essence Fine-Chemical Co., Ltd

Head Office:

9th Floor, No58 Nanhu Road, Nanjing 210017, PR China

Web: www.essencechem.com


Tel: +86-25-86518999 ext.836

Fax: +86-25-86455985

Nanjing Essence Fine-Chemical Co

Ltd is an ISO-9001:2008 certified

manufacturer and servicer specialized

in R&D, formulating, sub-packing and

exporting agrochemicals including

insecticides, fungicides, herbicides,

and PGRs.

With more than 10 years of research

achievements, we can produce more

than 800 formulated pesticides in

various formulations such as SC,

FS, EC, EW, SL, ME, SE, ULV, WP,

WDG, WSG, GR, SP, WS, DS, etc.

Packages are customized including

10mL-1000L for liquid formulations

and 1G-25KG for solid formulations.

Located in Luhe Fine Chemical

Industry Park of Nanjing, our factory

covers an area of 54,000 square meters

with total investment of USD 20

million.

We have achieved Quality Assurance

ISO9001, Environmental Standard

ISO14001, Health and Safety Standard

OHSAS18001.

Equipped with modern machinery

and highly sophisticated facilities,

we can produce best quality pesticide

formulations, which are subject to

FAO international criterions.

Our products are widely exported to

more than 50 countries, including

Southeast Asia, Middle East, Oceania,

Africa, America and Europe. We’re

ready to support our customers

in registration and we’ve assisted

customers to get our products

registered in nearly 60 countries.

The core value we hold is to exploit

more development with our partners

by providing quality products and

excellent services.

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Leading reports on crop protection markets, products and companiesREPORTS

Anhui Fengle Agrochemical Co., Ltd

CONTACT:

www.fengle-agrochem.com

Tel: 0086-551-65360940, 65326648 Fax: 65360941


[email protected]

Anhui Fengle Agrochemical Co Ltd, (a

full member of Fengle Seed Company

as a listed company on Chinese

Stock Exchange), is a leading basic

agrochemical producer in China.

Fengle Agrochem, an ISO 9001 certified

company, has become one of the largest

agrochemical exporter and producer

since it was founded in 1998.

Based on our state-of-the-art facilities and

in-house R&D scientists and engineers,

Fengle Agrochem is committed to

developing high quality crop protection

products for farmers all over the world.

Our products are being sold all over China

and exported to Europe, South America,

Middle East, Southeast Asia and other

foreign markets.

The products include herbicides,

fungicides, insecticides and seed

treatment products. Fengle Agrochem,

enjoying a high reputation in agrochemical industry, has also established long-term business relationship with some multinational corporations.

Fengle Agrochem has 12 sets of technical synthesis workshops with the production capacities for more than 20 kinds of active ingredients, and more than 60 sets of automatic packaging and formulation lines, which are able to produce more than 80,000 tons of formulations with the types of EC, EW, FS, ME, OF, SL, SC, SP, WDG, WP and so on.

The sizes of product package include100ml-200L for liquid formulations and 1g-25kg for solid formulations.

“Caring for the green life, Contributing to the golden harvest”.

Fengle Agrochem is committed to continuous innovation and bringing the happiness of harvest to each farmer.

Anhui Huaxing

Factory: Wujiang Town, Hexian County, Anhui Province, PR: China PC: 238251

Head office: No 6 Hongfeng Road, Hefei City, Anhui Province, PR: China PC: 230088

CONTACT:

Tel: 0086-551-65848128 / 0086-551-65848156 / 0086-551-65848131

Fax: 0086-551-65848133


URL: www.huaxingchem.com

Anhui Huaxing Chemical Industry Co., Ltd is a leading pesticide manufacturer and exporter with ISO 9001 and ISO 14001 certification in China. With annual turnover exceeding USD200 million, Huaxing is a listed company on the Chinese stock exchange. Huaxing boasts of 1 state grade technology center, 1 postdoctor workstation and 2 pesticide institutes. Based on the tremendous strengths of R&D and sophisticated technology, the company has more than 40 technical products and over 150 formulated products in three major series: insecticide, herbicide,

fungicide, including glyphosate, PMIDA, nicosulfuron, MCPA, fenoxaprop-P-ethyl, quizalofop-P-ethyl, carbendazim, fipronil, monomehypo, cartap, imidacloprid etc. Meanwhile, we integrate stringent environment management into our total production management system and have completed waste discharge management objectives on product facilities. Huaxing Chemical was awarded the honor of “Environmentally-friendly Enterprise in China” by National Environment Protection Administration. Huaxing Chemical is dedicated to global strategies. The company has registered many products in Southeast Asia, South Asia, Europe, North and South America and Africa.

Based on the international service platform and market development, Huaxing Chemical’s products have been exported to more than 40 countries. We provide comprehensive manufacturing, research & development, registration, marketing and technical support to our customers.

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