Figure E S M 1a.Δ V olum eA o vs.S troke D istanceA o: T ransonics F low Probe vs.D eltex E D M Dog 4/20- Baseline IVC Occlusion and Altered S tates 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 14.00 15.00 5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00 23.00 25.00 T ran so nics Flow P robe (m l) D eltex ED M (cm) Baseline P re N orepinephrine N orepinephrine P re N ipride N ipride P re D obutamine Dobutam ine AFP vs. EDM Baseline y = 1.1167x - 5.1519 R 2 = 0.9415 Pre Norepinephrine y = 0.7995x + 0.5933 R 2 = 0.6236 Norepinephrine y = 0.5369x + 1.1482 R 2 = 0.8694 Pre Nipride y = 0.5741x + 2.1024 R 2 = 0.962 Nipride y = 0.7009x + 0.6051 R 2 = 0.9405 Pre Dobutamine y = 0.8836x - 2.4988 R 2 = 0.93 Dobutamine
AFP vs. EDM Baseline y = 1.1167x - 5.1519 R 2 = 0.9415 Pre Norepinephrine y = 0.7995x + 0.5933
Jan 03, 2016
AFP vs. EDM Baseline y = 1.1167x - 5.1519 R 2 = 0.9415 Pre Norepinephrine y = 0.7995x + 0.5933 R 2 = 0.6236 Norepinephrine y = 0.5369x + 1.1482 R 2 = 0.8694 Pre Nipride y = 0.5741x + 2.1024 R 2 = 0.962 Nipride y = 0.7009x + 0.6051 R 2 = 0.9405 Pre Dobutamine - PowerPoint PPT Presentation
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Figure ESM 1a. ΔVolumeAo vs. Stroke DistanceAo: Transonics Flow Probe vs. Deltex EDM
Dog 4/20- Baseline IVC Occlusion and Altered States
5.00
6.00
7.00
8.00
9.00
10.00
11.00
12.00
13.00
14.00
15.00
5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00 23.00 25.00
Transonics Flow Probe (ml)
De
lte
x E
DM
(c
m)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. EDM
Baseline
y = 1.1167x - 5.1519
R2 = 0.9415
Pre Norepinephrine
y = 0.7995x + 0.5933
R2 = 0.6236
Norepinephrine
y = 0.5369x + 1.1482
R2 = 0.8694
Pre Nipride
y = 0.5741x + 2.1024
R2 = 0.962
Nipride
y = 0.7009x + 0.6051
R2 = 0.9405
Pre Dobutamine
y = 0.8836x - 2.4988
R2 = 0.93
Dobutamine
y = 0.9327x - 7.7759
R2 = 0.9702
Figure ESM 1b. Bland-Altman Analysis:
Transonics Flow Probe vs. Deltex EDM Dog 4/20- Baseline IVC Occlusion and Altered States
-10.00
-8.00
-6.00
-4.00
-2.00
0.00
5 7 9 11 13 15 17 19
(Deltex EDM+Transonics Flow Probe)/2
(De
lte
x E
DM
-Tra
ns
on
ics
Flo
w P
rob
e)
Baseline
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 2a. ΔVolumeLV vs. Stroke DistanceAO: Conductance Catheter vs. Deltex EDM
Dog 5/17- Baseline IVC Occlusion and Altered States
10.00
12.00
14.00
16.00
18.00
20.00
22.00
24.00
26.00
28.00
0.00 5.00 10.00 15.00 20.00 25.00 30.00 35.00
Conductance Catheter (ml)
De
lte
x E
DM
(c
m)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
CC vs. Deltex
Baseline
y = 1.5803x + 4.9921
R2 = 0.8907
Pre Norepinephrine
y = 0.9411x + 9.7971
R2 = 0.894
Norepinephrine
y = 0.8756x + 9.5455
R2 = 0.8849
Pre Nipride
y = 0.2731x + 16.589
R2 = 0.5655
Nipride
y = 0.8815x + 13.854
R2 = 0.8589
Pre Dobutamine
y = 0.302x + 15.776
R2 = 0.8693
Dobutamine
y = 0.3617x + 19.09
R2 = 0.9124
Figure ESM 2b. Bland-Altman Analysis:
Conductance Catheter vs. Deltex EDMDog 5/17- Baseline IVC Occlusion and Altered States
-10.00
-5.00
0.00
5.00
10.00
15.00
0 5 10 15 20 25 30 35
(De ltex EDM +Conductance Catheter)/2
(De
lte
x E
DM
-Co
nd
uc
tan
ce
Ca
the
ter)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 2c. Conductance Catheter vs. PiCCO Dog 5/17- Baseline IVC Occlusion and Altered States
10.00
12.00
14.00
16.00
18.00
20.00
22.00
24.00
0.00 5.00 10.00 15.00 20.00 25.00 30.00 35.00
Conductance Catheter (ml)
PiC
CO
(m
l)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. PCCO
Baseline
y = 0.4669x + 13.619
R2 = 0.7998
Pre Norepinephrine
y = 0.3824x + 12.466
R2 = 0.8354
Norepinephrine
y = 1.1473x + 6.8051
R2 = 0.9264
Pre Nipride
y = 0.3471x + 12.689
R2 = 0.9056
Nipride
y = 0.3133x + 9.9684
R2 = 0.9297
Pre Dobutamine
y = 0.2118x + 15.883
R2 = 0.9073
Dobutamine
y = 0.4657x + 13.682
R2 = 0.9679
Figure ESM 2d. Bland-Altman Analysis:
Conductance Catheter vs. PiCCODog 5/17- Baseline IVC Occlusion and Altered States
-15.00
-10.00
-5.00
0.00
5.00
10.00
15.00
0 5 10 15 20 25 30
(PiCCO+Conductance Catheter)/2
(PiC
CO
-Co
nd
uc
tan
ce
Ca
the
ter)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 3a. ΔVolum eLV vs. Stroke DistanceAO: Conductance Catheter vs. Deltex EDM
Dog 6/04- Baseline IVC Occluison and Altered States
5.00
10.00
15.00
20.00
25.00
30.00
5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00 23.00
Conductance Catheter (ml)
De
lte
x E
DM
(c
m)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
CC vs. EDM
Baseline
y = 0.3136x + 13.7
R2 = 0.9804
Pre Norepinephrine
y = 0.6394x + 8.6848
R2 = 0.5697
Norepinephrine
y = 0.6451x + 1.9371
R2 = 0.6878
Pre Nipride
y = 0.1766x + 9.1314
R2 = 0.9006
Nipride
y = 2.9286x - 7.983
R2 = 0.5909
Pre Dobutamine
y = 0.4666x + 19.52
R2 = 0.9016
Dobutamine
y = 0.596x + 6.1785
R2 = 0.9976
Figure ESM 3b. Bland-Altman Analysis:
Conductance Catheter vs. Deltex EDMDog 6/04- Baseline IVC Occlusion and Altered States
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
5 7 9 11 13 15 17 19 21 23 25
(De ltex EDM +Conductance Cathe ter)/2
(De
lte
x E
DM
-Co
nd
uc
tan
ce
Ca
the
ter) Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 3c. Conductance Catheter vs. PiCCO Dog 6/04- Baseline IVC Occlusion and Altered States
4.00
6.00
8.00
10.00
12.00
14.00
16.00
18.00
5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00 23.00
Conductance Catheter (ml)
PiC
CO
(m
l)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. PCCO
Baseline
y = 0.1999x + 9.4397
R2 = 0.932
Pre Norepinephrine
y = 0.2162x + 8.2763
R2 = 0.4108
Norepinephrine
y = 1.1789x - 4.7965
R2 = 0.6238
Pre Nipride
y = 0.3074x + 4.526
R2 = 0.4597
Nipride
y = 0.5855x + 1.584
R2 = 0.6378
Pre Dobutamine
y = 0.3835x + 9.3934
R2 = 0.9707
Dobutamine
y = 0.5648x + 2.5527
R2 = 0.94
Figure ESM 3d. Bland-Altman Analysis:
Conductance Catheter vs. PiCCODog 6/04- Baseline IVC Occlusion and Altered States
-8.00
-6.00
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
4 6 8 10 12 14 16 18 20
(PiCCO+Conductance Catheter)/2
(PiC
CO
-Co
nd
uc
tan
ce
Ca
the
ter)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 4a. ΔVolumeAO vs. Stroke DistanceAO: Transonics Flow Probe vs. Deltex EDM
Dog 6/11- Baseline IVC Occlusion and Altered States
5.00
7.00
9.00
11.00
13.00
15.00
17.00
19.00
21.00
7.00 9.00 11.00 13.00 15.00 17.00 19.00
Transonics Flow Probe (ml)
De
lte
x E
DM
(c
m)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. EDM
Baseline
y = 0.799x + 7.2887
R2 = 0.8412
Pre Norepinephrine
y = 1.0683x + 0.9032
R2 = 0.792
Norepinephrine
y = 0.7076x + 2.8312
R2 = 0.9928
Pre Nipride
y = 0.9884x + 1.3863
R2 = 0.9748
Nipride
y = 1.2168x + 1.2722
R2 = 0.9274
Pre Dobutamine
y = 0.182x + 11.74
R2 = 0.9809
Dobutamine
y = 1.2495x - 5.6067
R2 = 0.9601
Figure ESM 4b. Bland-Altman Analysis:
Transonics Flow Probe vs. Deltex EDMDog 6/11- Baseline IVC Occlusion and Altered States
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
5 7 9 11 13 15 17 19 21 23 25
(De ltex EDM +Transonics Flow Probe)/2
(De
lte
x E
DM
-Tra
ns
on
ics
Flo
w P
rob
e)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 4c. Transonics Flow Probe vs. PiCCO Dog 6/11- Baseline IVC Occlusion and Altered States
5.00
7.00
9.00
11.00
13.00
15.00
17.00
19.00
7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00
Transonics Flow Probe (ml)
PiC
CO
(m
l)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. PCCO
Baseline
y = 0.6363x + 7.5808
R2 = 0.9692
Pre Norepinephrine
y = 0.4473x + 5.0976
R2 = 0.7301
Norepinephrine
y = 0.6459x + 3.8957
R2 = 0.9222
Pre Nipride
y = 0.4362x + 6.3943
R2 = 0.935
Nipride
y = 0.9042x - 1.2429
R2 = 0.9912
Pre Dobutamine
y = 0.3807x + 9.6242
R2 = 0.7499
Dobutamine
y = 0.3551x + 9.5883
R2 = 0.9192
Figure ESM 4d. Bland-Altman Analysis:
Transonics Flow Probe vs. PiCCODog 6/11- Baseline IVCO and Altered States
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
5 7 9 11 13 15 17 19 21 23 25
(PiCCO+Transonics Flow Probe)/2
(PiC
CO
-Tra
ns
on
ics
Flo
w P
rob
e)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 5a. ΔVolumeAO vs. Stroke DistanceAO: Transonics Flow Probe vs. Deltex EDM
Dog 6/12- Baseline IVC Occlusion and Altered States
10.00
15.00
20.00
25.00
30.00
35.00
5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00
Transonics Flow Probe (ml)
De
lte
x E
DM
(c
m)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. EDM
Baseline
y = 0.6619x + 12.231
R2 = 0.9176
Pre Norepinephrine
y = 0.85x + 10.824
R2 = 0.7794
Norepinephrine
y = 0.8684x + 7.1179
R2 = 0.9859
Pre Nipride
y = 1.1964x + 5.2966
R2 = 0.952
Nipride
y = 1.4587x + 6.2218
R2 = 0.9666
Pre Dobutamine
y = 1.2691x + 5.5189
R2 = 0.9511
Dobutamine
y = 0.5272x + 13.531
R2 = 0.7984
Figure ESM 5b. Bland-Altman Analysis:
Transonics Flow Probe vs. Deltex EDMDog 6/12- Baseline IVC Occlusion and Altered States
-1.00
1.00
3.00
5.00
7.00
9.00
11.00
13.00
15.00
10 12 14 16 18 20 22 24 26
(De ltex EDM +Transonics Flow Probe)/2
(De
lte
x E
DM
-Tra
ns
on
ics
Flo
w P
rob
e)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
Figure ESM 5c. Transonics Flow Probe vs. PiCCO Dog 6/12- Baseline IVC Occlusion and Altered States
5.00
10.00
15.00
20.00
25.00
30.00
35.00
5.00 7.00 9.00 11.00 13.00 15.00 17.00 19.00 21.00
Transonics Flow Probe (ml)
PiC
CO
(m
l)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
AFP vs. PCCO
Baseline
y = 0.8308x + 7.3814
R2 = 0.9158
Pre Norepinephrine
y = 0.787x + 16.336
R2 = 0.923
Norepinephrine
y = 0.9483x + 2.1417
R2 = 0.9805
Pre Nipride
y = 1.0038x + 8.3511
R2 = 0.8997
Nipride
y = 0.5823x + 12.105
R2 = 0.9578
Pre Dobutamine
y = 0.5658x + 14.915
R2 = 0.9253
Dobutamine
y = 1.1214x + 11.908
R2 = 0.9697
Figure ESM 5d. Bland-Altman Analysis:
Transonics Flow Probe vs. PiCCODog 6/12- Baseline IVC Occlusion and Altered States
-1.00
1.00
3.00
5.00
7.00
9.00
11.00
13.00
15.00
17.00
5 10 15 20 25 30
(PiCCO+Transonics Flow Probe)/2
(PiC
CO
-Tra
ns
on
ics
Flo
w P
rob
e)
Baseline
Pre Norepinephrine
Norepinephrine
Pre Nipride
Nipride
Pre Dobutamine
Dobutamine
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