SciLifeLab, Science for Life Laboratory, is a Swedish research center within molecular biosciences with fo- cus on health and environment. To further strength- en the research environment at SciLifeLab the center regularly recruits young, talented research leaders to become SciLifeLab fellows. Each fellow is recruited by one of the center host universities and receives funding from them. One of the SciLifeLab fellows is Jens Carlsson, who was recruited by Uppsala University/SciLifeLab from Stockholm University, Sweden, in 2015. Afer fnishing his postdoctoral research at the University of California in San Francisco, Jens Carlsson returned to Sweden where he was born. “I received a start-up grant from a Swedish foundation that gave me the opportunity to build up an independ- ent research group at Stockholm University. I wanted to return to Sweden because family life, with two small children, became very complicated in the US. In Swe- den, we are spoiled with generous parental leave and “Diverse and ambitious environment at SciLifeLab” www.scilifelab.se subsidized day care – life is easier here” “I was working at the Stock- holm node of SciLifeLab when I applied for the fel- lows position. It is a won- derful place that connected me to the other universities represented at the center in ways that had not happened before. Te relatively young community at SciLifeLab creates a high ambition level and the international re- cruitment has given rise to a great and diverse environ- ment, which I think will beneft research in Sweden for many years to come.” Looking to recruit more people Jens Carlsson’s research focuses on the family of G-Pro- tein Coupled Receptors (GPCRs). He uses computer models of these receptors to understand how they work at the atomic level. As GPCRs are important drug targets, Jens and his colleagues also design small mole- cules that modulate receptor activity. “Around 30-40% of all drugs target GPCRs so more or less everyone will take one of these at some point in their life.” Jens Carlsson said. “Instead of testing millions of molecules experimentally as they do in the pharmaceutical industry, we can screen them on a su- per computer center over night and identify the most promising candidates at essentially no cost.” Jens Carlsson’s frst PhD student recently graduated and today his group consists of fve researchers. He is now looking to recruit more students. “I just had an interview with a candidate who I hope will be the frst in my group to do experimental work. Tis will be very exciting because it will give me the possibility to quickly test computational predictions ex- perimentally and thereby explore many new ideas.” SciLifeLab – a national resource SciLifeLab is a Swedish research center within molecular biosciences with focus on health and environment. It is also a national center with the mission to develop, use and provide advanced tech- nologies. The center infrastructure encompasses a multitude of biomolecular technologies and bioin- formatics services. National funding makes SciLife- Lab’s services and expertise available to researchers in all of Sweden. The center is a joint effort by four Swedish univer- sities (Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala Uni- versity). Founded in 2010, the center today encom- passes more than 1 200 researchers mainly located in and around the two center nodes in Stockholm and Uppsala. Photo: Håkan Lindgren Jens Carlsson ADVERTISEMENT
10
Embed
ADVERTISEMENT “Diverse and ambitious environment at ... · extraction, Phree phospholipid removal, Impact protein precipitation plates, ˘ ˘ Clarity BioSolutions for synthetic
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
SciLifeLab, Science for Life Laboratory, is a Swedishresearch center within molecular biosciences with fo-cus on health and environment. To further strength-en the research environment at SciLifeLab the centerregularly recruits young, talented research leaders tobecome SciLifeLab fellows. Each fellow is recruitedby one of the center host universities and receivesfunding from them.
One of the SciLifeLab fellows is Jens Carlsson, whowas recruited by Uppsala University/SciLifeLab fromStockholm University, Sweden, in 2015. Afer fnishinghis postdoctoral research at the University of Californiain San Francisco, Jens Carlsson returned to Swedenwhere he was born.
“I received a start-up grant from a Swedish foundationthat gave me the opportunity to build up an independ-ent research group at Stockholm University. I wantedto return to Sweden because family life, with two smallchildren, became very complicated in the US. In Swe-den, we are spoiled with generous parental leave and
“Diverse and ambitious environment at SciLifeLab”
www.scilifelab.se
subsidized day care – life iseasier here”
“I was working at the Stock-holm node of SciLifeLabwhen I applied for the fel-lows position. It is a won-derful place that connectedme to the other universitiesrepresented at the center inways that had not happenedbefore. Te relatively youngcommunity at SciLifeLabcreates a high ambition leveland the international re-cruitment has given rise to a great and diverse environ-ment, which I think will beneft research in Sweden formany years to come.”
Looking to recruit more peopleJens Carlsson’s research focuses on the family of G-Pro-tein Coupled Receptors (GPCRs). He uses computermodels of these receptors to understand how theywork at the atomic level. As GPCRs are important drugtargets, Jens and his colleagues also design small mole-cules that modulate receptor activity.
“Around 30-40% of all drugs target GPCRs so moreor less everyone will take one of these at some pointin their life.” Jens Carlsson said. “Instead of testingmillions of molecules experimentally as they do in thepharmaceutical industry, we can screen them on a su-per computer center over night and identify the mostpromising candidates at essentially no cost.”
Jens Carlsson’s frst PhD student recently graduatedand today his group consists of fve researchers. He isnow looking to recruit more students.
“I just had an interview with a candidate who I hopewill be the frst in my group to do experimental work.Tis will be very exciting because it will give me thepossibility to quickly test computational predictions ex-perimentally and thereby explore many new ideas.”
SciLifeLab – a national resource
SciLifeLab is a Swedish research center withinmolecular biosciences with focus on health andenvironment. It is also a national center with themission to develop, use and provide advanced tech-nologies. The center infrastructure encompasses amultitude of biomolecular technologies and bioin-formatics services. National funding makes SciLife-Lab’s services and expertise available to researchersin all of Sweden.
The center is a joint effort by four Swedish univer-sities (Karolinska Institutet, KTH Royal Institute ofTechnology, Stockholm University and Uppsala Uni-versity). Founded in 2010, the center today encom-passes more than 1 200 researchers mainly locatedin and around the two center nodes in Stockholmand Uppsala.
Photo
:H
åkan
Lindgre
n
Jens Carlsson
ADVERTISEMENT
Thousandsof single cells.
One solution.
Introducing the Illumina Bio-Rad Single-Cell Sequencing Solution.
Access high-resolution insights into gene expression in a single,
comprehensive workflow.
Single-cell RNA-Seq delivers higher resolution of gene regulation for a deeper view of cell function, disease
progression, and identification of therapeutic targets in research, compared to RNA-Seq. Developed by the
industry leaders in sequencing and Droplet Digital™ technologies, our robust, scalable, and user-friendly
workflow allows transcriptome profiling of hundreds to tens of thousands of single cells.
Gain insights into your research.
Learn more at bio-rad.com/ddSEQsinglecell
For Research Use Only. Not for use in diagnostic procedures.
The Keystone Symposia2017 Conference SeriesCell Plasticitywithin theTumorMicroenvironment (A1)Organizers: Sergei Grivennikov, Florian R. Greten &Mikala EgebladJan 8–12, 2017 | Big Sky Resort | Big Sky, Montana | USA
PrecisionGenomeEngineering (A2)Organizers: J. Keith Joung, Emmanuelle Charpentier & Olivier DanosJan 8–12, 2017 | Beaver Run Resort | Breckenridge, Colorado | USA
Transcriptional and Epigenetic Control in StemCells (J1)Organizers: Konrad Hochedlinger, Kathrin Plath &MariusWernig
joint with
Neurogenesis duringDevelopment and in the Adult Brain (J2)Organizers: Alysson R. Muotri, Kinichi Nakashima & Xinyu ZhaoJan 8–12, 2017 | Resort at Squaw Creek | Olympic Valley, California | USA
TGF-ß in Immunity, Inflammation andCancer (A3)Organizers:Wanjun Chen, Joanne E. Konkel & Richard A. FlavellJan 9Ð13, 2017 | Sagebrush Inn & Suites | Taos, NewMexico | USA
Mitochondria Communication (A4)Organizers: Jared Rutter, Cole M. Haynes &Marcia C. HaigisJan 14–18, 2017 | Sagebrush Inn & Suites | Taos, NewMexico | USA
NewDevelopments inOur Basic Understanding ofTuberculosis (A5)Organizers: Samuel M. Behar &Valerie MizrahiJan 14–18, 2017 | Fairmont Hotel Vancouver | Vancouver,British Columbia | Canada
PI3K Pathways in Immunology, GrowthDisorders andCancer (A6)Organizers: Leon O. Murphy, Klaus Okkenhaug & Sabina C. CosulichJan 19–23, 2017 | Hilton Santa Fe Historic Plaza Hotel | Santa Fe,NewMexico | USA
Biobetters andNext-Generation Biologics:Innovative Strategies forOptimally EfectiveTherapies (A7)Organizers: CheriŽ L. Butts, Amy S. Rosenberg, Amy D. Klion& Sachdev S. SidhuJan 22Ð26, 2017 | Snowbird Resort | Snowbird, Utah | USA
Diabetes (J3)Organizers: Jiandie Lin, Clay F. Semenkovich & Rohit N. Kulkarnijoint withObesity andAdiposeTissue Biology (J4)Organizers: Marc L. Reitman, Ruth E. Gimeno & Jan NedergaardJan 22Ð26, 2017 | Keystone Resort | Keystone, Colorado | USA
Omics Strategies to Study the Proteome (A8)Organizers: Alan Saghatelian, Chuan He & IleanaM. CristeaJan 29ÐFeb 2, 2017 | Beaver Run Resort | Breckenridge, Colorado | USA
Epigenetics andHumanDisease:Progress fromMechanisms toTherapeutics (A9)Organizers: Johnathan R.Whetstine, Jessica K. Tyler & Rabinder K. PrinjhaJan 29ÐFeb 2, 2017 | Sheraton Seattle Hotel | Seattle,Washington | USA
Hematopoiesis (B1)Organizers: Catriona H.M. Jamieson, Andreas Trumpp & Paul S. FrenetteJan 31ÐFeb 4, 2017 | Fairmont Banff Springs | Banff, Alberta | Canada
Noncoding RNAs: FromDisease toTargetedTherapeutics (J5)Organizers: Kevin V. Morris, Archa Fox & Paloma Hoban GiangrandejointwithProtein-RNA Interactions: Scale,Mechanisms, Structureand Function of Coding andNoncoding RNPs (J6)Organizers: GeneW.Yeo, Jernej Ule, Karla Neugebauer &Melissa J. MooreFeb 5–9, 2017 | Fairmont Banff Springs | Banff, Alberta | Canada
Inflammation-Driven Cancer:Mechanisms toTherapy (J7)Organizers: FionaM. Powrie, Michael Karin & Alberto MantovanijointwithMicrobiome inHealth andDisease (J8)Organizers: Julie A. Segre, Ramnik Xavier &WilliamMichael DunneFeb 5–9, 2017 | Keystone Resort | Keystone, Colorado | USA
AutophagyNetwork Integration inHealth andDisease (B2)Organizers: Ivan Dikic, Anna Katharina Simon & J.Wade HarperFeb 12–16, 2017 | Copper Mountain Resort | Copper Mountain,Colorado | USA
Asthma: FromPathwayBiology to PrecisionTherapeutics (B3)Organizers: Clare M. Lloyd, JohnV. Fahy & SallyWenzel-MorganrothFeb 12–16, 2017 | Keystone Resort | Keystone, Colorado | USA
Viral Immunity:Mechanisms andConsequences (B4)Organizers: Akiko Iwasaki, Daniel B. Stetson & E. JohnWherryFeb19–23, 2017 |Hilton Santa FeHistoric PlazaHotel | Santa Fe,NewMexico | USA
Malaria: From Innovation to Eradication (B5)Organizers:MarcelTanner, SarahK.Volkman,MarcusV.G. Lacerda&SalimAbdullaFeb 19–23, 2017 | Speke Resort & Conference Centre | Kampala | Uganda
Lipidomics andBioactive Lipids inMetabolismandDisease (B6)Organizers:AlfredH.Merrill,WalterAllenShaw,SarahSpiegel&Michael J.O.WakelamFeb 26–Mar 2, 2017 | GranlibakkenTahoe | Tahoe City, California | USA
Bile Acid Receptors as Signal Integratorsin Liver andMetabolism (C1)Organizers: Luciano Adorini, Kristina Schoonjans & Scott L. FriedmanMar 3–7, 2017 | Hyatt RegencyMonterey | Monterey, California| USA
Rare andUndiagnosedDiseases:Discovery andModels of PrecisionTherapy (C2)Organizers: William A. Gahl & Christoph KleinMar 5–8, 2017 | Fairmont Copley Plaza | Boston, Massachusetts | USA
mRNAProcessing andHumanDisease (C3)Organizers: James L. Manley, SiddharthaMukherjee & Gideon DreyfussMar 5–8, 2017 | Sagebrush Inn & Suites | Taos, NewMexico | USA
Synapses andCircuits: Formation, Function andDysfunction (X1)Organizers: Tony Koleske, Yimin Zou, Kristin Scott & A. Kimberley McAllisterjoint withConnectomics (X2)Organizers: Olaf Sporns, Danielle Bassett & Jeremy FreemanMar 5–8, 2017 | Eldorado Hotel & Spa | Santa Fe, NewMexico | USA
Kinases: Next-Generation Insights andApproaches (C4)Organizers: Reid M. Huber, John Kuriyan & Ruth H. PalmerMar 5–9, 2017 | Beaver Run Resort | Breckenridge, Colorado | USA
TumorMetabolism:Mechanisms andTargets (X3)Organizers: Brendan D. Manning, Kathryn E.Wellen & Reuben J. Shawjoint withAdaptations toHypoxia in Physiology andDisease (X4)Organizers: M. Celeste Simon, Amato J. Giaccia & Randall S. JohnsonMar 5–9, 2017 |Whistler Conference Centre |Whistler, British Columbia |Canada
EngineeredCells andTissuesasPlatformsforDiscoveryandTherapy (K1)Organizers: Laura E. Niklason, Milica Radisic & Nenad BursacMar 9–12, 2017 | Fairmont Copley Plaza | Boston, Massachusetts | USA
LIFE SCIENCE RESEARCH
CONFERENCES HELD WORLDWIDE
www.keystonesymposia.org/meetings
Frontiers of NMR in Life Sciences (C5)Organizers: KurtWüthrich, Michael Sattler & StephenW. FesikMar 12–16, 2017 | Keystone Resort | Keystone, Colorado | USA
Sex andGender Factors AffectingMetabolic Homeostasis,Diabetes andObesity (C6)Organizers: Franck Mauvais-Jarvis, Deborah Clegg & Arthur P. ArnoldMar 19–22, 2017 | GranlibakkenTahoe | Tahoe City, California | USA
Cancer Immunology and Immunotherapy:Taking a Place inMainstreamOncology (C7)Organizers: Robert D. Schreiber, James P. Allison, Philip D. Greenberg& Glenn DranoffMar 19–23, 2017 | Fairmont ChateauWhistler |Whistler, British Columbia |Canada
Pattern Recognition Signaling:From Innate Immunity to InfammatoryDisease (X5)Organizers: Thirumala-Devi Kanneganti, Vishva M. Dixit &Mohamed Lamkanfijoint withType I Interferon: Friend and FoeAlike (X6)Organizers: Alan Sher, Virginia Pascual, Adolfo García-Sastre & Anne O’GarraMar 19–23, 2017 | Fairmont BanfSprings | Banf, Alberta | Canada
Injury, Inflammation and Fibrosis (C8)Organizers: Tatiana Kisseleva, Michael Karin & AndrewM. TagerMar 26–30, 2017 | Snowbird Resort | Snowbird, Utah | USA
HIVVaccines (C9)Organizers: Andrew B.Ward, Penny L. Moore & Robin ShattockMar 26–30, 2017 | Sheraton Steamboat Resort | Steamboat Springs,Colorado | USA
ImmuneRegulation inAutoimmunity andCancer (D1)Organizers: David A. Hafler, Vijay K. Kuchroo & Jane L. GroganMar 26–30, 2017 |Whistler Conference Centre |Whistler, British Columbia |Canada
MolecularMechanisms of Heart Development (X7)Organizers: Benoit G. Bruneau, Brian L. Black &Margaret E. Buckinghamjoint withRNA-BasedApproaches in Cardiovascular Disease (X8)Organizers: Thomas Thum& Roger J. HajjarMar 26–30, 2017 | Keystone Resort | Keystone, Colorado | USA
Genomic Instability andDNARepair (Z1)Organizers: Julia Promisel Cooper, Marco F. Foiani & Geneviève Almouznijoint withDNAReplication andRecombination (Z2)Organizers: John F.X. Diffey, Anja Groth & Scott KeeneyApr 2–6, 2017 | Santa Fe Community Convention Center | Santa Fe,NewMexico | USA
B Cells andT Follicular Helper Cells:Controlling Long-Lived Immunity (D2)Organizers: Stuart G. Tangye, Ignacio Sanz & Hai QiApr 23–27, 2017 |Whistler Conference Centre |Whistler,British Columbia | Canada
ModelingViral Infections and Immunity (E1)Organizers: Alan S. Perelson, Rob J. De Boer & Phillip D. HodgkinMay 1–4, 2017 | Stanley Hotel | Estes Park, Colorado | USA
Angiogenesis andVascular Disease (Z3)Organizers: M. Luisa Iruela-Arispe, Timothy T. Hla & Courtney Grifinjoint withMitochondria,MetabolismandHeart (Z4)Organizers: Junichi Sadoshima, Toren Finkel & Åsa B. GustafssonMay 8–12, 2017 | Eldorado Hotel & Spa | Santa Fe, NewMexico | USA
Neuronal Control of Appetite,MetabolismandWeight (Z5)Organizers: Lora K. Heisler & Scott M. Sternsonjoint withGastrointestinal Control ofMetabolism (Z6)Organizers: Randy J. Seeley, Matthias H. Tschšp & FionaM. GribbleMay 9Ð13, 2017 | Tivoli Hotel and Congress Center | Copenhagen | Denmark
Aging andMechanisms of Aging-RelatedDisease (E2)Organizers: KazuoTsubota, Shin-ichiro Imai, Matt Kaeberlein & JoanMannickMay 15–19, 2017 | PacifcoYokohama |Yokohama | Japan
Single Cell Omics (E3)Organizers: Sarah Teichmann, EvanW. Newell &William J. GreenleafMay 26–30, 2017 | Clarion Hotel Sign | Stockholm | Sweden
IntegratingMetabolismand Immunity (E4)Organizers: Hongbo Chi, Erika L. Pearce, Richard A. Flavell & Luke A.J. O’Neill
jointwithCell Death and Inflammation (K2)Organizers: Seamus J. Martin & John SilkeMay 29–Jun 2, 2017 | Royal Dublin Society | Dublin | Ireland
Neuroinflammation: Concepts, Characteristics, Consequences (E5)Oganizers: RichardM. Ransohoff, Christopher K. Glass &V. Hugh PerryJun 19–23, 2017 | Keystone Resort | Keystone, Colorado | USA
Vectors, Pathogens andDiseases:CurrentTrends and Emerging Challenges (T1)Organizers: Maureen Coetzee, Josiane Etang, StephenTorr & Scott L. O’NeillSep 10–14, 2017 | Durban, KwaZulu-Natal | South Africa
Maternal-Fetal Cross Talk: Harmony vs. Confict (T2)Organizers: JefMurray, Louis J. Muglia &Yoel SadovskyOct 4–8, 2017 |Washington, DC | USA
Regenerative Biology and Applications: Cell Diferentiation,Tissue Organization and Biomedical Engineering (T3)Organizers: Paul K. Tam, Urban Lendahl & Freda D. MillerOct 15–19, 2017 | Pok Fu Lam, Hong Kong | China
Antimicrobials and Resistance: Opportunities and Challenges (T4)Organizers: GautamDantas & Jennifer A. LeedsOct 29–Nov 1, 2017 | Santa Fe, NewMexico | USA
Frontiers of Serotonin Beyond the Brain (T5)Organizers: Michael D. Gershon & LucMaroteauxNov 12–15, 2017 | Park City, Utah | USA
Abstract and discounted registration deadlines are three and twomonths, respectively, before conferences begin. Abstracts must be submitted by the abstract deadline to be considered forshort talksbutcanstillbesubmitted forposterpresentationthroughthediscountedregistrationdeadline.Conferences typicallybeginwithafternoonregistrationandaneveningwelcomemixeron the frst advertised day and conclude with an evening plenary session followed by food and entertainment on the last advertised day. Some program formats vary. Please view up-to-datedetails for each conference atwww.keystonesymposia.org and then / and the alpha-numericprogramcode (e.g.,www.keystonesymposia/17A1). All programs subject to possible change.
ZOOM
Y
X
Position your research with our newImageXpress® Micro 4 High-Content Imaging System
• Tackle your toughest assays with an imaging platform that adapts to your needs
• Image over 15 million cells per hour in a 3-color cell scoring assay
• Acquire and analyze in both 2D and 3D using our seamless, integrated end-to-end solution
• Drive your research with a system that builds on over 30 years of innovation in imaging
moleculardevices.com/ixm4
A M E R I C A N A S S O C I A T I O N F O R T H E A D V A N C E M E N T O F S C I E N C E
AAAS, publisher of Science, thanks the sponsors andsupporters of the 2017 Annual Meeting
As of December 1, 2016
SERVING SOCIETY THROUGH
SCIENCE POLICY
Browse the Online Program and Register Now
Register and book your hotel now to use funds from 2016.
Advance registration rates are available through January 27, 2017.
AAASmembers are eligible for further discounts.
aaas.org/meetings
for its generous support ofthe Science Journalism Awards
Congratulationsto the 2016Winners
The Golden Goose Award
honors federally funded
researcherswhosework
may have seemed odd
or obscure when it was
conducted but which led to
major breakthroughs and
significant societal benefit.
Nominations for 2017 are
nowbeing accepted.
www.goldengooseaward.org
Peter Bearman, Barbara
Entwisle, Kathleen Mullan
Harris, Ronald Rindfuss
and Richard Udry
A Tale of Two Studies: The
Adolescent Health Story
Edward F. Knipling and
Raymond C. Bushland
The Sex Life of the
Screwworm Fly
John J. Bartholdi III, Sunil
Nakrani, Thomas D. Seeley,
Craig A. Tovey and John
Hagood Vande Vate
The Honey Bee Algorithm
Visit the website and start planning today!
myIDP.sciencecareers.org
Features inmyIDP include:
§ Exercises to help you examine your skills, interests,
and values.
§ A list of 20 scientific career paths with a prediction of
which ones best fit your skills and interests.
§ A tool for setting strategic goals for the coming year, with
optional reminders to keep you on track.
§ Articles and resources to guide you through the process.
§ Options to savematerials online and print them for further
review and discussion.
§ Ability to select which portion of your IDP you wish to
share with advisors, mentors, or others.
§ A certificate of completion for users that finishmyIDP.
Produced by the Science/AAAS Custom Publishing Office
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/about/new-products-section for more information.
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations
are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any
products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.