www.microsharp.co.uk 52 Shrivenham Hundred Business Park Watchfield, Oxfordshire, SN6 8TY. UK Innovators in Light Management Technology Advances in Automated Cytology Screening www.microsharp.co.uk Nikolai Ptitsyn [email protected]Pathology Visions 2007 Amsterdam Marriott Hotel 4-5 December 2007
Pathology Visions 2007 Amsterdam Marriott Hotel 4-5 December 2007. Advances in Automated Cytology Screening. Nikolai Ptitsyn [email protected]. www.microsharp.co.uk. Cervical Cancer. Malignant cancer of the cervix Represents a major women health problem - PowerPoint PPT Presentation
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
www.microsharp.co.uk52 Shrivenham Hundred Business ParkWatchfield, Oxfordshire, SN6 8TY. UK
07/11/2007 Advances in automated cytology screening 2
• Malignant cancer of the cervix• Represents a major women
health problem• In some developing countries
commonest female cancer• In developed countries
the widespreaduse of programsreduced the incidence of cervical cancer by 50%or more Age standardised incidence
and mortality rates in 2002
Cervical Cancer Screening in England 2006
• 4.4 million women were invited for screening
• 3.6 million women were screened
• 4 million samples examined
• 75% of cancer cases prevented in women who attend regularly cervical screening
• £150 millions is the overall cost to NHS
• Recent introduction of the vaccine against HPV requires making more cost-effective use of limited resources
– Eduardo Franco, "Process of care failures in invasive cervical cancer: Systematic review and meta-analysis", Elsevier, Preventive Medicine, Volume 45, number 2-3, August-September 2007
07/11/2007 Advances in automated cytology screening 3
Project Summary
• Phase 1 : January 2005 – September 2007– digitise and analyse 3 500 cervical slides at 20-40X
– develop methodology, algorithms and software
– build the integrated screening system on top of Scanscope
– complete a clinical study
• Phase 2 : October 2007 – December 2007– switch from class-based to regression-based model
– extend the training dataset
– fix recognition problems
– repeat the tests against the existing dataset
07/11/2007 Advances in automated cytology screening 4
St George’s Healthcare
Key Research Outcome: New Diagnostic Approach
• Accurate quantification of different cells across entire cytological specimen at full resolution in 5-10 minutes– 103-106 cells found on ∅20 mm monolayer spot
• Cell global statistics– tissue types, cancer stages, spatial densities
• Cell context description and analysis– cell relationships and concurrence
• Nonlinear regression of a cancerstaging function in the feature space– modeling visual changes during
development of cancer
07/11/2007 Advances in automated cytology screening 5
Fine Segmentation
07/11/2007 Advances in automated cytology screening 6
Multi Hypothesis Segmentation
• Black line: minor hypothesis (rejected)• White line: dominant hypothesis (accepted)
07/11/2007 Advances in automated cytology screening 7