29.11.2018 1 Advanced Imaging Techniques X-Nuclei Imaging Prof. Dr. Frank G. Zöllner Computer Assisted Clinical Medicine Medical Faculty Mannheim Heidelberg University Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim, Germany [email protected]www.ma.uni-heidelberg.de/inst/cbtm/ckm Name I Slide 2 I 11/29/2018 Learning Goals introduction to advanced imaging techniques in MR, CT and CBCT basic MRI principles -> Physics of Imaging Techniques Goals: 1. How does the technique work ? 2. What kind of images do we receive? 3. Where is this applied to ? Literature is given in the respective lectures Slides of the lectures at https://www.umm.uni-heidelberg.de/inst/cbtm/ckm/lehre/index.html
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29.11.2018
1
Advanced Imaging TechniquesX-Nuclei Imaging
Prof. Dr. Frank G. ZöllnerComputer Assisted Clinical MedicineMedical Faculty Mannheim Heidelberg University
� introduction to advanced imaging techniques in MR, CT and CBCT
� basic MRI principles -> Physics of Imaging Techniques
� Goals:
1. How does the technique work ?
2. What kind of images do we receive?
3. Where is this applied to ?
� Literature is given in the respective lectures
� Slides of the lectures at https://www.umm.uni-heidelberg.de/inst/cbtm/ckm/lehre/index.html
29.11.2018
2
Name I Slide 3 I 11/29/2018
Reading� Wetterling et al., Sodium-23 magnetic resonance imaging during and
after transient cerebral ischemia: multinuclear stroke protocols fordouble-tuned 23Na/1H resonator systems . Phys. Med. Biol. 2012(57) 6929
� Konstandin & Schad. 30 years of sodium/X-nuclei magnetic resonance imaging. Magn Reson Mater Phy (2014) 27: 1
� Konstandin, S. Development of 2D Radial Techniques for Sodium MRI with Application to Abdominal Imaging at 3Tesla.PhD Thesis, Heidelberg University, 2012
� Konstandin & Nagel. Measurement techniques for magnetic resonance imaging of fast relaxing nuclei. Magn Reson Mater Phy(2014) 27: 5
� Eisele, et al. Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI. Multiple Sclerosis.(2016). http://doi.org/10.1177/1352458515609430
Name I Slide 4 I 11/29/2018
Outline
�Motivation
�Challenges of X-Nuclei MRI
� Imaging Techniques of 23Na
�Applications
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Motivation
� Ion fluxes in cells play an important role of cell activity� sodium–potassium pump (Na+–K+-ATPase), which pumps
3 Na+ ions out of and 2 K+ into the cell. � active transport mechanism is one factor
to keep the resting membrane potentialin cells at about −70 mV