Adipose tissue dysfunction and visceral fat are associated to hepatic insulin resistance and severity of NASH even in lean individuals

Adipose tissue dysfunction and visceral fat are associated to hepatic insulin resistance and severity of NASH even in lean individuals 1,$ * Chiara Saponaro, 1 Silvia Sabatini, 1 Melania Gaggini, 1 Fabrizia Carli, 2 Chiara Rosso, 4 Vincenzo Positano, 2 Angelo Armandi, 2 Gian Paolo Caviglia, 2 Riccardo Faletti, 2 Elisabetta Bugianesi, 1,* Amalia Gastaldelli. 1 Cardiometabolic Risk Unit, Institute of Clinical Physiology, CNR, Pisa, Italy. 2 Division of Gastroenterology and Hepatology and Lab. of Diabetology, Dept. of Medical Sciences, University of Turin, Turin, Italy. 3 Fondazione Toscana Gabriele Monasterio, Pisa, Italy. $ Current affiliation: Univ. Lille, CHU Lille, Inserm U1190, EGID, Lille, France. *Correspondence to: Amalia Gastaldelli, PhD, Head of Cardiometabolic Risk Unit Institute of Clinical Physiology, CNR via Moruzzi 1 56100 Pisa Italy tel: +39 050 3152679/80 fax: +39 050 3152166 email: [email protected] Chiara Saponaro, PhD University of Lille, CHU Lille, Inserm U1190, EGID Faculté de Médecine de Lille, Pôle Recherche 1, Place de Verdun 59045 - Lille, France email: [email protected] Number of words: 4051 Number of Tables: 1 Number of Figures: 4 Number of Supplementary Tables: 0 preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this this version posted January 21, 2022. ; https://doi.org/10.1101/2022.01.19.476711 doi: bioRxiv preprint

Adipose tissue dysfunction and visceral fat are associated to hepatic insulin resistance and severity of NASH even in lean individuals

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