Adhesion Adhesion molecules and molecules and lymphocyte homing lymphocyte homing 成成 成成成成 成成成成 成成成 成成成 成成成成 成成 :、、、、、 成成 成成成成 成成成成 成成成 成成成 成成成成 成成 :、、、、、
Jan 13, 2016
Adhesion Adhesion molecules and molecules and
lymphocyte lymphocyte hominghoming 成员:艾戈弋、鲍梦馨、车飞、陈超、成员:艾戈弋、鲍梦馨、车飞、陈超、董丽花、姜琳董丽花、姜琳
reviewreview
Definition of adhesion Definition of adhesion molecules molecules
Cell adhesion molecules (CAMs) are Cell adhesion molecules (CAMs) are cell surface proteins involved in the icell surface proteins involved in the interaction of cell-cell or cell-extracelnteraction of cell-cell or cell-extracellular matrix. lular matrix.
CAMs take effect by the binding of reCAMs take effect by the binding of receptor and ligand ceptor and ligand
ClassificationClassification
Integrin familyIntegrin family Selectin family Selectin family Immunoglobulin (Ig) superfamilyImmunoglobulin (Ig) superfamily Cadherin family Cadherin family Mucin-like familyMucin-like family Other adhesion moleculesOther adhesion molecules
IntegrinsIntegrins
SelectinSelectin
ISFISF
CadherinCadherin
Lymphocyte homingLymphocyte homing
The directed migration of subsetThe directed migration of subset
s of circulating lymphocytes into s of circulating lymphocytes into particular tissue sites.particular tissue sites.
ClassificationClassification
Lymphoid stem cell migrate to Lymphoid stem cell migrate to central lymphoid organscentral lymphoid organs
Mature lymphocyte migrate to Mature lymphocyte migrate to peripheral lymphoid organsperipheral lymphoid organs
Recirculation of lymphocytesRecirculation of lymphocytes Lymphocyte migrate to the sites Lymphocyte migrate to the sites
of inflammation of inflammation
How adhesion How adhesion molecules molecules
participate in participate in homing ?homing ?
Adhesion molecules Adhesion molecules mediate the process of mediate the process of
hominghoming Lymphocyte homing receptor (LHR) Lymphocyte homing receptor (LHR)
express on lymphocyteexpress on lymphocyte
Addressin Addressin
express on vascular endothelial cellexpress on vascular endothelial cell
Adhesion Molecules on Adhesion Molecules on LymphocyteLymphocyte
lymphocytlymphocyte adhere, e adhere, penetrate penetrate vascular vascular
endotheliaendothelial celll cell
Adhesion molecules Adhesion molecules participate in lymphocyte participate in lymphocyte
hominghomingLymphocyte homing receptor Lymphocyte homing receptor Addressins Addressins AdhesioAdhesion n moleculmoleculeses
FunctionsFunctions AdhesioAdhesion n moleculmoleculeses
FunctionsFunctions
L-selectiL-selectin n
Lymphocyte homing Lymphocyte homing to peripheral immune to peripheral immune organs organs
PNAdPNAd Addressin of Addressin of peripheral high peripheral high venous endothelial cell venous endothelial cell
CLA CLA Receptor on memory Receptor on memory T cell surface for T cell surface for directionally homing directionally homing to skin to skin
E-E-selectin selectin
Express on vascular Express on vascular endothelial cell of endothelial cell of inflammation portion inflammation portion of skin of skin
LFA-1 LFA-1 Participate in many Participate in many lymphocytes for lymphocytes for homing homing
ICAM-1ICAM-1
ICAM-2 ICAM-2 Participate in many Participate in many lymphocytes for lymphocytes for homing homing
Adhesion molecules Adhesion molecules participate in lymphocyte participate in lymphocyte
hominghomingLymphocyte homing receptor Lymphocyte homing receptor Addressins Addressins AdhesioAdhesion n moleculmoleculeses
FunctionsFunctions AdhesioAdhesion n moleculmoleculeses
FunctionsFunctions
VLA-4 VLA-4 Receptor of Receptor of lymphocyte homing lymphocyte homing
VCAMVCAM --1 1
Express on vascular Express on vascular endothelial cell of endothelial cell of inflammation portion inflammation portion
CD44 CD44 Participate in many Participate in many lymphocytes homing lymphocytes homing
MAdMAd Intestinal lymphatic tissIntestinal lymphatic tissue and lamina propria ue and lamina propria
integrin integrin Receptor of lymphocytReceptor of lymphocyte for directionally mige for directionally migrate to Peyre's Patch rate to Peyre's Patch
MAdMAd Addressin of vascular Addressin of vascular endothelial cell endothelial cell
α4β7α4β7
Adhesion molecules in Adhesion molecules in normal condition in normal condition in lymphocyte hominglymphocyte homing
Pro-T cell migrate to Pro-T cell migrate to thymus thymus
Homing receptorHoming receptor: : CD44CD44 and and L-selectinL-selectin expressed by pro-T cell expressed by pro-T cell
AdressinAdressin: : EA1EA1 molecule expressed by t molecule expressed by thymus vascular endothelial cell hymus vascular endothelial cell
And integrin And integrin α6β1α6β1 、、 α6β4α6β4 play an imp play an important role in adhesion of pro-T cell ortant role in adhesion of pro-T cell
Lymphocyte migrate to Lymphocyte migrate to peripheral lymphoid organs peripheral lymphoid organs Lymphocytes migrate to lymph nodeLymphocytes migrate to lymph node
Homing receptorHoming receptor: : L-selectinL-selectin on lymphocyte on lymphocyte AdressinAdressin :: peripheral lymphonode vascular addperipheral lymphonode vascular add
ressin (ressin (PNAdPNAd) )
LFA-1LFA-1//ICAM-1ICAM-1 、、 ICAM-2ICAM-2 and and CD44CD44//Mad Mad molecmolecules participate in the adhesion and penetration ules participate in the adhesion and penetration
Lymphocyte migrate to Peyer’s PatcLymphocyte migrate to Peyer’s Patchh
Homing receptorHoming receptor: integrin : integrin α4β7α4β7 molecule molecule ; ; CD4CD444 and and LFA-1LFA-1 molecules molecules
AdressinAdressin: Vascular endothelial cell of peyre’s pa: Vascular endothelial cell of peyre’s patch specifically highly express mucosal vascular tch specifically highly express mucosal vascular addressin (addressin (MadMad); ); ICAM-1ICAM-1 、、 ICAM-2ICAM-2
Peyre’s patch means the aggregated lymphoid Peyre’s patch means the aggregated lymphoid nodule in small intestine.nodule in small intestine.
Lymphocyte migrate to Lymphocyte migrate to peripheral lymphoid organs peripheral lymphoid organs
Lymphocyte Lymphocyte hominghoming
Adhesion molecules in Adhesion molecules in pathological condition pathological condition
(inflammation) in (inflammation) in lymphocyte hominglymphocyte homing
Function of adhesion Function of adhesion molecules in inflammationmolecules in inflammation
Lymphocyte migrate to Lymphocyte migrate to inflammation of skin inflammation of skin
Homing receptorHoming receptor: cutaneous lymphocyt: cutaneous lymphocyte-associated antigen (e-associated antigen (CLACLA)) ;; VLA-4VLA-4 ;;LFA-1LFA-1
AdressinAdressin: E-selectin : E-selectin ;; VCAM-1VCAM-1; ; ICAICAM-1M-1//ICAM-2ICAM-2
Lymphocyte migrate to Lymphocyte migrate to inflammation of skin inflammation of skin
Lymphocyte migrate to Lymphocyte migrate to inflammation of intestinal inflammation of intestinal
mucosa mucosa
Molecule expressed by lymphocyte Molecule expressed by lymphocyte of intestinal mucous tissue called of intestinal mucous tissue called mucosal lymphocyte antigen (mucosal lymphocyte antigen (MLAMLA))
Lymphocyte migrate to inflamLymphocyte migrate to inflammation of synovium mation of synovium
Homing receptorHoming receptor: : LFA-1 LFA-1 ; ; VLA-4 VLA-4 ; ; CD44CD44
AdressinAdressin: : ICAM-1ICAM-1 ;; VCAM-1VCAM-1 ;; MadMad
DiseaseDisease
Hyper-expressing adhesion Hyper-expressing adhesion molecules molecules
Hypo-expressing adhesion moleculesHypo-expressing adhesion molecules
HoHowevwever…er…
more mechanism more mechanism needneeded to be ed to be explored…explored…
Thank youThank you