Albemarle is one of the few firms in the world with the facilities and expertise to help you with product development at every stage, from contract research, process development and the pilot plant right through commercial-scale manufacturing. To us, “the yes formula” is all about the world-class facilities, exceptional people and proven expertise that combine to help make you successful. And we continue to demonstrate our commitment by bringing you additional custom services that make a real difference in high-stakes industries. What’s new with us? Plenty. Cryogenics Our Fine Chemistry Services (FCS) division recently added new equipment at the Orangeburg, South Carolina, facility to meet growing customer demand for specialized reactions involving extreme low temperatures. The equipment allows us to run cryogenic reactions to temperatures as low as -90° C at a 2,700-gallon scale, and has already been used to carry out a synthetic step for a drug intermediate at the new operational limit. Targeted investments such as this large-scale cGMP cryogenic reaction system position us well to develop and scale-up reactions to make APIs and late-stage pharmaceutical intermediates. Allowing our experts to better serve diverse customer needs simultaneously helps ensure the success of all their projects. Specialty Polymerization FCS recently invested in facilities to serve Albemarle’s cGMP and specialized non-cGMP polymer markets. Within the last year, we have: • Added drying capacity and small-scale (kilo lab) capabilities at one facility for cGMP biomedical and pharmaceutical polymer applications; and • Upgraded custom manufacturing capabilities and expertise at other facilities to produce new and unique polymers for electronics, coatings, specialized polyolefin and other applications. Albemarle has developed, manufactured and improved polymer catalysts and catalyst systems on custom, confidential and commercial bases for more than 40 years. With flexible and scalable custom manufacturing assets at several U.S. plants, we have the expertise and facilities to meet a wide range of polymer manufacturing needs. CGMP AND FOOD-GRADE HYDROGENATION Albemarle FCS features two facilities fully capable of both cGMP and food-grade hydrogenation: Orangeburg, South Carolina • Strong GMP culture – more than 20 years manufacturing ibuprofen • Additional experience with injectable APIs • FDA registered: no Form 483s in more than 20 years • FDA Food Facility Registration • ISO 9001:2000 Certified since 2003 South Haven, Michigan • FDA Registered: Manufacturing APIs since 1978 • FDA Food Facility Registration • Currently supports more than 25 FDA-registered products Our combined equipment includes: • Four (4) cGMP or food-grade hydrogenation units • 2,000- to 2,700-gallon capacity • Stainless steel and Hastelloy ® alloy construction • Up to 150 psig hydrogen Additional Custom Services: More Ways We Can Say Yes