The impacts of HLA class I alleles on HIV-1 The impacts of HLA class I alleles on HIV-1 plasma virus loads in a unique Asian population plasma virus loads in a unique Asian population with a narrow spectrum of HLA,and their changes with a narrow spectrum of HLA,and their changes at the population level over time at the population level over time Frequent Transmission of Cytotoxic-T-Lymphocyte Escape Mutants of Human Immunodeficiency Virus Type 1 in the Highly HLA- A24-Positive Japanese Population Tae Furutsuki, et al, JVI,2004 Adaptation of HIV-1 to human leukocyte antigen class I Yuka Kawashima, et al, Nature,2009 0 10 20 30 40 0 10 20 30 40 0 10 20 30 40 (A) Japanese 29 alleles (B) Caucasian (USA) (C) African Americans (USA) 46 alleles 50 alleles Allele frequency (%) HLA-A; red HLA-B; yellow HLA-C; blue 24 51 57 5 7 5 8 24 2 27 27 35 35
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Adaptation of HIV-1 to human leukocyte antigen class I Yuka Kawashima, et al, Nature,2009
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The impacts of HLA class I alleles on HIV-1 plasma virus The impacts of HLA class I alleles on HIV-1 plasma virus loads in a unique Asian population with a narrow spectrum of loads in a unique Asian population with a narrow spectrum of
HLA,and their changes at the population level over timeHLA,and their changes at the population level over time
Frequent Transmission of Cytotoxic-T-Lymphocyte Escape Mutants of Human
Immunodeficiency Virus Type 1 in the Highly HLA-A24-Positive Japanese Population
Tae Furutsuki, et al, JVI,2004
Adaptation of HIV-1 to human leukocyte antigen class I
Yuka Kawashima, et al, Nature,2009
0
10
20
30
400
10
20
30
400
10
20
30
40 (A) Japanese 29 alleles
(B) Caucasian (USA)
(C) African Americans (USA)
46 alleles
50 allelesAll
ele
freq
uen
cy
(%)
HLA-A; redHLA-B; yellowHLA-C; blue
24
51
57
5758
24
2
27
27
35
35
Alleles beneficial in U.S. are not protective in Japan