Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe! Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department.

Acute Respiratory Distress Acute Respiratory Distress SyndromeSyndrome

It’s so shocking, I can’t It’s so shocking, I can’t breathe!breathe!

Heidi Ditmyer DVMHeidi Ditmyer DVMUniversity of TennesseeUniversity of Tennessee

College of Veterinary MedicineCollege of Veterinary MedicineDepartment of PathobiologyDepartment of Pathobiology

Tifton 2008Tifton 2008Presented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on

SEVPAC website onlySEVPAC website only

SignalmentSignalment Juvenile Female Spayed Yorkshire Juvenile Female Spayed Yorkshire

TerrierTerrier

Presented to rDVM after chewing Presented to rDVM after chewing electric cordelectric cord

rDVM treated with Oxygen and rDVM treated with Oxygen and diureticsdiuretics

Presented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on


Case 07-796Case 07-796 Referred to UT Referred to UT

VentilatorVentilator

FebrileFebrile

Died 24 hours post arrivalDied 24 hours post arrival



Gross FindingsGross Findings

Glossal and gingival ulcerationGlossal and gingival ulceration

Bilateral interstitial pneumoniaBilateral interstitial pneumonia

Congenital portosystemic shunt Congenital portosystemic shunt



Glossal ulceration Glossal ulceration







Histology and etiologyHistology and etiology

Fibrinous interstitial pneumoniaFibrinous interstitial pneumonia

Multiple possibilitiesMultiple possibilities

Consistent with Acute Respiratory Consistent with Acute Respiratory Distress SyndromeDistress Syndrome



Acute Respiratory Distress Acute Respiratory Distress Syndrome (ARDS)Syndrome (ARDS)

Acute onsetAcute onset

Bilateral/diffuse pulmonary changesBilateral/diffuse pulmonary changes

HypoxemiaHypoxemia

No evidence of left atrial hypertensionNo evidence of left atrial hypertensionPresented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on


ARDSARDS Secondary inflammatory responseSecondary inflammatory response

Macrophages Macrophages cytokines cytokines enzymes enzymes free radicals free radicals diffuse diffuse alveolar and endothelial damagealveolar and endothelial damage

Differential diagnosis for any animal Differential diagnosis for any animal with non-cardiogenic pulmonary with non-cardiogenic pulmonary edema and appropriate risk factorsedema and appropriate risk factors



ConclusionConclusion

Limited lung response regardless of Limited lung response regardless of triggertrigger

Overzealous inflammatory responseOverzealous inflammatory response

Pathophysiology not entirely Pathophysiology not entirely understoodunderstood

Considered as differential diagnosisConsidered as differential diagnosisPresented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on


AcknowledgementsAcknowledgements

Dr Kim NewkirkDr Kim Newkirk

UT histology staffUT histology staff



Thank youThank you

www.k9station.com

Questions?Questions?Presented at SEVPAC 2008 – Presented at SEVPAC 2008 – Permission granted for use on Permission granted for use on


Acute Respiratory Distress Syndrome It’s so shocking, I can’t breathe! Heidi Ditmyer DVM University of Tennessee College of Veterinary Medicine Department.

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