11/26/14 1 HOW TO MAXIMIZE YOUR RESUSCITATION POTENTIAL IN TRAUMA PATIENTS ? NARAIN CHOTIROSNIRAMIT MD. TRAUMA AND CRITICAL CARE UNIT, DEPARTMENT OF SURGERY, FACULTY OF MEDICINE CHIANGMAI UNIVERSITY INTRODUCTION Populations number Number of death Estimated road traffic death rate per 100,000 populations Niue 1,465 1 68.3 Dominican Republic 9,927,320 2,470 40.1 Thailand 69,122,232 13,365 38.1 Venezuela 28,979,857 7,714 37.2 Iran 73,973,628 23,247 34.1 Nigeria 158,423,184 5,279 33.7 South Africa 50,132,820 14,804 31.9 • PERMISSIVE HYPOTENSION • BEDSIDE MONITORING FOR RESUSCITATION • HEMOSTATIC RESUSCITATION • RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION FOR AORTA PERMISSIVE HYPOTENSION
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HOW TO MAXIMIZE YOUR RESUSCITATION POTENTIAL
IN TRAUMA PATIENTS ?
NARAIN CHOTIROSNIRAMIT MD. TRAUMA AND CRITICAL CARE UNIT,
DEPARTMENT OF SURGERY, FACULTY OF MEDICINE CHIANGMAI UNIVERSITY
INTRODUCTION
Populations number
Number of death
Estimated road traffic death
rate per 100,000
populations
Niue 1,465 1 68.3
Dominican Republic 9,927,320 2,470 40.1
Thailand 69,122,232 13,365 38.1
Venezuela 28,979,857 7,714 37.2
Iran 73,973,628 23,247 34.1
Nigeria 158,423,184 5,279 33.7
South Africa 50,132,820 14,804 31.9
• PERMISSIVE HYPOTENSION
• BEDSIDE MONITORING FOR
RESUSCITATION
• HEMOSTATIC RESUSCITATION
• RESUSCITATIVE ENDOVASCULAR
BALLOON OCCLUSION FOR AORTA
PERMISSIVE HYPOTENSION
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Kenneth L. MaYox
William H. Bickell, et al. N Engl J Med. Volume 331, Oct 1994 :1105-‐1109
PERMISSIVE HYPOTENSION
Single center , prospec\ve , randomized , controlled trial in Houston 1989-‐1992.
598 adult trauma with penetra\ng torso injury & SBP < 90 mm Hg.
1. Immediate resuscita\on ( IR )
2. Delayed resuscita\on (DR)
PERMISSIVE HYPOTENSION
“Hypotensive pa\ents with penetra\ng injuries of the chest and abdomen :
Deferring fluid admin : improves outcome”
William H. Bickell, et al. N Engl J Med. Volume 331, Oct 1994 :1105-‐1109
PERMISSIVE HYPOTENSION
Favorable results in delayed fluid resuscita\on Capone, AC, Safar, P, Stezoski, W, et al. J Am Coll Surg 1995; 180:49
Owens, TM, Watson, WC, Prough, DS, et al. J Trauma 1995; 39:200.. Silbergleit, R, Satz, W, McNamara, RM, et al. Acad Emerg Med 1996; 3:922.
Kim, SH, Stezoski, SW, Safar, P, et al. J Trauma 1997; 42:213. Solomonov, E, Hirsh, M, Yahiya, A, Krausz, MM. Crit Care Med 2000; 28:749.
TARGET BLOOD PREESURE ? Fluid administra\on to maintain the MAP in
the 60-‐80 mmHg range is advisable and appropriate.
Hai SA.J Pak Med Assoc. 2004 Aug;54(8):434-‐6.
PERMISSIVE HYPOTENSION TARGET BLOOD PREESURE ?
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PERMISSIVE HYPOTENSION TARGET BLOOD PREESURE ?
• 80 rats 8 groups : Different target MAPs (control, 40, 50, 60, 70, 80, 90 mmHg, and sham) on
fluid resuscita\on of uncontrolled hemorrhagic shock.
PERMISSIVE HYPOTENSION TARGET BLOOD PREESURE ?
• Conclusion Too-‐low MAP resuscita\on results in
Less blood loss and lower fluid therapy
Greater proinflammatory cytokine response
Higher mortality than resuscita\on at higher MAP of uncontrolled hemorrhagic shock.
MAP of 60 mmHg is the target BP for hypotensive resuscita\on.
PERMISSIVE HYPOTENSION TARGET BLOOD PREESURE ?
Uncontrolled hemorrhage, hypotensive resuscita\on to MAP 60 mmHg may be the op\mal target MAP
Yu YH, et al. Resuscita`on 2009;80:1424–30.
PERMISSIVE HYPOTENSION TARGET BLOOD PREESURE ?
If Bleeding stop
No Permissive hypotension
WARNING
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BEDSIDE MONITORING
OF RESUSCITATION
FAST
Extend to Rt/Lt Chest Cavity E-‐FAST
• Hemothorax • Pneumothorax
sensi\vity 92-‐100% specificity 91-‐100%
Husain LF, Hagopian L, Wayman D, Baker WE, Carmody KA. Sonographic diagnosis of pneumothorax. J Emerg Trauma Shock. 2012;5(1):76–81.
Sign of Pneumothorax
-‐ Loss of lung sliding sign -‐ “Absent of Seashore sign” or “Stratosphere sign” or “Barcode sign”
Rao R. Ivatury
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BEDSIDE MONITORING OF RESUSCITATION
Invasive hemodynamic monitoring in the trauma bay ?
BEDSIDE MONITORING OF RESUSCITATION
Underresuscita\on & overresuscita\on have life-‐threatening consequences.
Balogh Z,et al. Am J Surg. 2002;184:538Y543.
Kasotakis G, et al. J Trauma Acute Care Surg. 2013;74:1215-‐1221.
BEDSIDE MONITORING OF RESUSCITATION
Hypothesis :
LTTE is a useful tool to guide therapy in hypotensive trauma pa\ents during the ini\al phase of resuscita\on
BEDSIDE MONITORING OF RESUSCITATION
PATIENTS AND METHODS
• Pa\ents at any point during the ini\al presenta\on or en route had : sBP < 100 mmHg Mean BP < 60mmHg Pulse > 120 beats /min
Randomized : LTTE performed (LTTEp) Not performed (non-‐LTTE)
1St July – 31st December 2012.
• Windows obtained included the following:
Parasternal long
Parasternal short
Apical and subxyphoid.
BEDSIDE MONITORING OF RESUSCITATION
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• Repor\ng the Results of the LTTE Contrac\lity
Fluid status
Pericardial effusion.
BEDSIDE MONITORING OF RESUSCITATION
• Fluid Status IVC size and collapsibility Hypovolemic : IVC < 2 cm and collapsible. Ventricular filling Hypovolemia : Hyperdynamic heart. (ventricle that is closing nearly 100%,with almost
no blood at the end of systole)
BEDSIDE MONITORING OF RESUSCITATION
Collapsible inferior vena cava, long axis view
Inferior vena cava plethora long axis view
Fluid Status
IVCD (mm)
Caval Index (%)
RAP (mmHg)
< 20 > 50 5 < 20 < 50 10 > 20 < 50 15 > 20 0 20
Spontaneous breathing à Collapsibility
Gunst et al. Bedside Echocardiographic Assessment for Trauma/Cri;cal Care: The BEAT Exam. J Am Coll Surg Vol. 207, No. 3, Sep 2008
Inferior vena cava assessment
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• Contrac\lity Good or poor.
No calcula\ons of the ejec\on frac\on
No comments of ventricular wall mo\on abnormali\es.
Assessment of global heart func\on only.
BEDSIDE MONITORING OF RESUSCITATION
M-‐mode tracing demonstra\ng excellent contrac\lity. RV: right ventricle, LV: leo ventricle
M-‐mode tracing demonstra\ng poor contrac\lity. LV: leo ventricle
• Pericardial Effusion Presence or the absence of effusion only No commen\ng on the physiology of the
heart.
BEDSIDE MONITORING OF RESUSCITATION
Cardiac tamponade, subxiphoid view. RV: right ventricle, RV: right atrium, LV: leo ventricle, LA: leo atrium, PE: pericardial effusion
215 pa\ents in the study. 92 LTTEp 123 non-‐LTTE
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BEDSIDE MONITORING OF RESUSCITATION
Conclusion • LTTE was a useful tool to guide therapy. The LTTEp group to receive less IVF and
aided in the resuscita\on process. • The appropriate image-‐guided resuscita\on perhaps contributed to decreased mortality in the LTTEp group
1–3% of civilian trauma Mortality rates 50–70% Fakhry SM, Sheldon GF. American Associa`on of Blood Banks, 1994.
Bri`sh CommiZee for Standards in Haematology. BrJ Haematol 2006; 135:634-‐41
Acute coagulopathy of trauma is ooen
present before any resuscita\ve efforts Brohi K, Singh J, Heron M, Coats T. J Trauma. 2003;54:1127–1130.
MacLeaod JB, Lynn M, McKenney MG, et al. J Trauma. 2003; 55:39–44.
Acute traumacc coagulopathy (ATC)
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• Prospec\ve, observa\onal study • Popula\ons: 45 trauma pa\ents • Compare: the on-‐scene coagula\on profile at the scene of the accident, before fluid administra\on, and on hospital admission Rela\on between coagula\on status and injury severity score
on-‐scene and in the emergency room.
On Scene
ER
Conclusion : Coagulacon abnormalices Appear very early ader injury Before fluid administracon 60% of pacents. Upon hospital admission, the on-‐scene
coagulopathy was the same or worsened in 96% of the pacents
Acute traumacc coagulopathy (ATC)
Acute traumacc coagulopathy (ATC)
Trauma + Shock • Trauma
– Increase \ssue injury, inflamma\on
– Increase thrombin produc\on • Cleave fibrinogen to fibrin • Poten\ate procoagulant process • Ac\va\on of protein C
– Consump\ve coagulopathy
• Hypoperfusion – Elevate levels of protein C – Elevate thrombomodulin -‐> Thrombomodulin-‐bound thrombin • Ac\va\on of protein C • Impairing clot forma\on • Fibrinolysis is enhanced
– Release of t-‐PA from vascular endothelial cells and subsequent hyperfibrinolysis
How can we predict of MT ? Clinical scoring system
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TASH Score TASH Score
McLaughlin score McLaughlin score
McLaughlin DF. J Trauma. 2008;64:S57–S63.
ABC score ABC score
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ABC score
ABC > 2, 75% sensicve, 86% specific
Prediccve Tools for MT in Trauma ABC TASH McLaughlin Hsu et al.
BP ≤ 90 SBP (categorical)
< 110 Hct < 32% pH < 7.25
-‐
HR ≥ 120 > 120 > 105 -‐
FAST FAST+ FAST+ -‐ FAST+
Mechanism Penetracng Complex long bone or pelvic
Fx -‐ -‐
Demographics -‐ Male -‐ -‐
LAB -‐ Hb (categorical), BE (categorical)
Hct < 32% pH < 7.25
BE < -‐5 INR > 1.5
AUROC 0.859 0.887 0.747 0.859
Riskin DJ, Tsai TC, Riskin L, et al. J Am Coll Surg. 209( 2), August 2009, 198-‐205
RESULT RESULT
• Lower the mortality
• High raco of FFP: Early studies showed • Higher ARDS and MOF incidences
Resuscita\ve Endovascular Balloon Occlusion of the Aorta
(REBOA)
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REBOA
Balloon occlusion : an adjunct for shock was reported during the Korean War.
Hughes CW.. Surgery. 1954;36:65-‐68.
• Ra\onale : Aor\c occlusion supports myocardial and
cerebral perfusion un\l resuscita\on can be ini\ated and hemostasis obtained. Same goals of open aor\c cross clamping. REBOA : less invasive , decrease morbidity.
White JM, et al. Surgery. 2011;150:400-‐409. Burlew CC, et al. J Trauma Acute Care Surg. 2012;73(6): 1359-‐1363; discussion
1363-‐1364.
Dorlac WC, et al. J Trauma. 2005;59(1):217-‐222.
REBOA
Intraopera\ve angiogram performed through a side-‐port of the sheath demonstrates renal arteries aoer stent deployment with balloon s\ll inflated
Brenner ML, Moore LJ, Dubose JJ, et al. J Trauma. 2013 Sept 75(3), 506-‐511
Pa\ent 1 2 3 4 5 6 Age 62 24 59 25 40 27 Sex M M M M M F Mechanism injury MVC GSW GSW MVC MCC ATV Injury Severity Score (ISS) 28 50 9 25 48 43
SBP before REBOA 70 70 0 60 70 85 SBP aoer REBOA 135 122 100 110 130 125 Cardiac arrest before REBOA No No Yes No No NO
Time to occlusion 5 4 4 6 6 6 Time of occlusion 12 16 70 60 65 36 Outcome Alive Alive Alive Alive Brain
death Death
Brenner ML, Moore LJ, Dubose JJ, et al. J Trauma. 2013 Sept 75(3), 506-‐511
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• REBOA resulted in : Mean (SD) increase in BP of 55 (20) mm Hg Mean (SD) aor\c occlusion \me was 18
(34) mins. No REBOA-‐related complica\ons. No hemorrhage-‐related mortality.
Brenner ML, Moore LJ, Dubose JJ, et al. J Trauma. 2013 Sept 75(3), 506-‐511
REBOA
The Endovascular Skills for Trauma and Resuscita\ve Surgery (ESTARS) curriculum has been developed.
Stannard A, et al . J Trauma. 2011;71(6):1869-‐1872. Villamaria CY, et al. 72nd Annual Mee`ng of the AAST and Clinical Congress of Acute Care Surgery.
BEST course
ALL PERFORM IN OR (NEED FLUOROSCOPY)
POSSIBLE IN ER ?
ScoZ DJ, et al. J Trauma Acute Care Surg. Volume 75, Number 1 122-‐128
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Accurate balloon posi\oning
87.5% VS 100%.
One device entered a right renal artery
Similar increases in MAP, caro\d blood flow, and par\al pressure of brain oxygena\on
REBOA POSSIBLE TO DO IN ER
Trauma with Hypotension (Extremis)
Access Common Femoral artery for A-‐Line or REBOA