http://www.acro-scale.co.jp/ Acroscale Inc. Sendai laboratory +81-22-752-2211 [email protected] Saito, F. ; Sakamoto, I. ; Kanatani, A. ; Chiba, Y. Biochimica et Biophysica Acta, 2016, 1860, 1809-1820. Sakamoto, I. ; Tezuka, K. ; Fukae, K. ; Ishii, K. ; Taduru, M. ;Maeda, M. ; Ouchi, K. ; Yoshida, Y. ; Nambu, Y. ; Igarashi, J. ; Hayashi,N. ; Tsuji, T. ; Kajihara, Y. J. Am. Chem. Soc., 2012, 134, 5428-5431. 1 RESEARCH RESULTS CHEMICAL APPROACH TOWARD GLYCOPROTEINS Academic paper 65th ASMS Conference on Mass Spectrometry and Allied Topics, (2017, 6), Indianapolis. 137th Annual Meeting of the Pharmaceutical Society of Japan, (2017, 3), Sendai. PepTalk: The Protein Science Week, (2014, 1), Palm Springs. 3 2 Conference presentation HPLC profiles of chemically synthesized and recombinant INF-β HILITE 1 Our chemical synthesis method can produce any desired glycoprotein in high purity and with homogeneous oligosaccharides Synthetic homogeneous sialyl-IFN- β Sakamoto, I., et al. J. Am. Chem. Soc. 2012, 134, 5428-5431 Control over exact quantity and purity Synthetic INF-β-1a (non-fucosylated) Commercial 1 Commercial 2 Unpublished data Treatment for multiple sclerosis Treatment for glioblastoma as well as hepatitis B and C