ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH New Bone Growth Substance for Treatment of Osteoporosis and Bone Fracture Healing.

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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New Bone Growth Substance for Treatment ofOsteoporosis and Bone Fracture Healing

Hiroki Yokota, PhDBiomedical Engineering, IUPUI

Make bone strong!

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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rest/recoveryphosphorylated

eIF2eIF2

stress to endoplasmic

reticulum (ER)

damage/aging

oxidation

variousstress

sources

hypoxiaischemia

nutrientdeprivation

salubrinal

Rationale

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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salu

brin

al

pla

ceb

o

anterior surgical hole (day 20)

day

1 2 3 4 5 6 7 8 9 10 20

salubrinalinjection harvestharvest

surgery

anterior hole

posterior hole

salubrinalinjection

side

10 days 20 days

control salubrinal

2.0

0

ante

rio

r w

ou

nd

siz

e (m

m)

1.0

******1.0

0

0.5

10 days 20 days

*

**

po

ster

ior

cort

ical

th

ickn

ess

(mm

)

Rat Experiment

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Selection of vehicles (RISC support)

• Non toxic• Good solubility

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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diffusion

convection

circulation

subcutaneoustissue

blood

moleculartransport

molecularturnoverinjection

Pharmacokinetics

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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Acknowledgements

• Ping Zhang, IUSOM; Andy Chen, UCSD; Guofeng Wang, U. Pittsburg

• Matt Rubin, IURTC

• IU Kelly School of Business, Business of Life Sciences students

• DoD Congressionally Directed Medical Research Program

• Teresita Bellido, Anatomy & Cell Biology, IUSOM

• Munro Peacock, Endocrinology, IUSOM

• Jeffrey Anglen, Orthopedic Surgery, IUSOM