sdfgafgafga NEUTROPHIL GELATINASE- ASSOCIATED LIPOCALIN IS ELEVATED IN BILE FROM PATIENTS WITH MALIGNANT PANCREATOBILIARY DISEASE A. Zabron 1 , V. Horneffer-van der Sluis 2 , C. Wadsworth 1 , M. Gierula 2 , A. Thillainayagam 3 , P. Vlavianos 3 , D. Westaby 3 , S. Taylor-Robinson 1 , R. Edwards 2 , S. Khan 1 1 Hepatology and Gastroenterology Section, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, 2 Centre of Pharmacology and Therapeutics , Imperial College London, 3 Gastroenterology Unit , Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom Previously presented at UEGW and BSG. Accepted for publication in the American Journal of Gastroenterology ACADEMIC TRAINEES ANNUAL EVENT 2011
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NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IS ELEVATED IN BILE FROM
PATIENTS WITH MALIGNANT PANCREATOBILIARY DISEASE A. Zabron1, V. Horneffer-van der Sluis 2, C. Wadsworth 1, M. Gierula 2, A.
Thillainayagam 3, P. Vlavianos3, D. Westaby 3, S. Taylor-Robinson 1, R. Edwards 2, S. Khan 1
1Hepatology and Gastroenterology Section, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, 2Centre of Pharmacology and Therapeutics , Imperial College London,3Gastroenterology Unit , Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
Previously presented at UEGW and BSG. Accepted for publication in the American Journal of Gastroenterology
ACADEMIC TRAINEES ANNUAL EVENT 2011
Content
• Focus on pancreatic adenocarcinoma
• Significance and current diagnostic difficulties
• Proteomic technique
• Results
• Possible clinical use and further work
• Summary
Pancreatic adenocarcinoma
• Imperial AHSC HPB tertiary referral centre
• 10th commonest cancer in the UK
• Mortality similar to incidence
• Diagnosis by cross-sectional imaging, histology / cytology and serum biomarkers imperfect