academic - Department of Medicine at Alpert Medical School

Department of MedicineRHODE ISLAND HOSPITAL/HASBRO CHILDREN’S HOSPITAL

THE MIRIAM HOSPITAL

MEMORIAL HOSPITAL OF RHODE ISLAND

WOMEN & INFANT’S HOSPITAL

VETERAN’S ADMINISTRATION MEDICAL CENTER

Department of MedicineAdministrative OfficesRhode Island HospitalMain Building, 1st Floor593 Eddy StreetProvidence, RI 02903

W W W . B R O W N M E D I C I N E . O R G

Department of MedicineA N N U A L R E P O R T — A C A D E M I C Y E A R S 2 0 0 1 - 2 0 0 2

Patient Care,Teaching &ResearchRhode Island Hospital/Hasbro Children’s HospitalThe Miriam HospitalMemorial Hospital of Rhode IslandWomen & Infant’s HospitalVeteran’s Administration Medical Center

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Brown University, Providence,and New England

Brown University, Providence and

Rhode Island together provide a

pleasant and interesting setting for

study, recreation, and daily life.

From atop College Hill the University

overlooks downtown Providence, the capital of

Rhode Island and the second largest city in

New England. The University was founded in

1764; its architecturally diverse buildings and

quadrangles center on the original College

Green. In the surrounding residential area are

many houses that date back to colonial times,

together with various historic sites, including

the Old State House, where independence in

America was first declared, and the First

Baptist Meeting House, the oldest Baptist

Church in America.

Contemporary life in Providence complements

the city’s interesting history. One can walk

from the campus to any of a variety of

restaurants, to the nationally renowned Trinity

Square Repertory Theater or a performance of

the Rhode Island Philharmonic Orchestra, or

to a jazz club or dance performance.

Attractions also include several art galleries,

including the museum of Brown’s college hill

neighbor, the Rhode Island School of Design.

On the Brown campus are plays, concerts,

movies, lectures, art exhibits and many other

sources of entertainment and intellectual

stimulation throughout the year. A modern

athletic complex within easy walking distance

from the main campus offers swimming in a

modern Olympic-sized pool, extensive

exercise equipment, squash and tennis courts,

and ice-skating, as well as playing fields and

facilities for intramural and varsity team

sports

Rhode Island is especially known for

recreational opportunities centered on the

ocean and Narragansett bay, including

boating, fishing, sailing and swimming.

Newport, the site of some of the nation’s most

magnificent mansions and for many years

home of the America’s Cup sailing races, is

less than an hour away. Providence is an hour

by car, bus or train from Boston, an hour

from Cape Cod, about three hours from

major New Hampshire and Vermont ski areas,

and three-and-one-half hours from New York

City. At Green Airport, ten minutes from

downtown Providence, several major airlines

offer frequent service to all major points in

the United States.

The Department of Medicine’s 2001-2002Annual Report was produced by: -’

Designer:

Printing:

Photography: , ’

Copy Edit and Proofing:

Special thanks to the followingfor their contributions: ’ ’

On the Cover:. . .

Photo by: ,

DIVISION HIGHLIGHTS

➤ Cardiology .............................................................................. 6

➤ Clinical Pharmacology .................................................... 22

➤ Endocrinology .................................................................... 28

➤ Gastroenterology ............................................................... 34

➤ General Internal Medicine ............................................ 44

➤ Geriatrics ............................................................................... 68

➤ Hematology/Oncology ................................................... 74

➤ Infectious Disease .............................................................. 88

➤ Nephrology ......................................................................... 108

➤ Obstetric & Consultative Medicine ......................... 118

➤ Pulmonary, Critical Care, & Sleep Medicine ...... 124

➤ Rheumatology ................................................................... 140

BROWN MEDICAL SCHOOL DEPARTMENT OF MEDICINE

C A R D I O L O G Y

CARDIOLOGY

OverviewRHODE ISLAND HOSPITAL

The Division of Cardiology experi-

enced a number of changes in 2001-2003,

which will enhance it both academically

and clinically.

Faculty growth continued with the

addition of Kristin Ellison, M.D.

(electrophysiology), Philip Stockwell,

M.D., and Katherine Stansmore, M.D and

Gary Katzman, M.D.. The

Electrophysiology fellowship was

expanded to 4 positions in a 2 year

program, and outside funding was

received for one of the positions in the

form of a NASPE Advanced Clinical

Training Award. The basic fellowship

match continued to bring high quality

graduates of US medical schools and

residencies.

The electrophysiology program continued

to grow clinically at both RIH and TMH.

Importantly, Dr. Alfred Buxton received a

large ($10 million) award from Medtronic

to continue his multicenter research on

the application of implanted defibrillators (the

MUSTT II trial).

The Cardiac Catheterization Laboratory continued to

be productive as a clinical research center with highly

innovative studies initiated to (1) evaluate a left atrial

appendage occluder for patients with atrial

fibrillation, (2) employ hyperoxemic antegrade

coronary perfusion following angioplasty for patients

with acute myocardial infarction and (3) apply optical

coherence tomography to image the lumen and walls

of coronary arteries in patients. Drug eluting stents

that became available clinically in the past year and

show promise to significantly reduce in-stent

restenosis underwent extensive testing and

development at RIH prior to FDA approval.

The Cardiovascular Research Laboratory was studying

ways to image angiogenesis, vascular smooth muscle

Albert Most, M.D., Professor of Medicine; Director,

Division of Cardiology, Rhode Island Hospital

proliferation and vascular apoptosis in swine

models. These studies are being conducted with NIH

funded RO1 support with Dr Lynne Johnson as PI.

The laboratory is scheduled to relocate from the

Southwest Pavilion into renovated space on Middle

House 3 in 2003-2004.

The Cardiac Catheterization Laboratory converted

to a completely filmless x-ray facility and the Echo

Laboratory digitized its operation.

Non-invasive cardiology and cardiac imaging: The

echocardiographic laboratory continues to do a high

volume of imaging and is on the forefront of ultra-

sound imaging technology including tissue Doppler,

3D echocardiographic imaging, and contrast echo-

cardiography. The nuclear cardiology laboratory also

continues to do a high volume of scans. A second

dual detector Vertex camera went on-line this year.

B R O W N M E D I C A L S C H O O L D E PA R T M E N T O F M E D I C I N E

All technetium labeled tracers are imaged with

attenuation correction to improve specificity. A

Phillips/ADAC multi-ring 3D PET camera was

installed in the Nuclear Medicine Department and

opened for clinical imaging April 2003. Tumor

imaging represents the major indication for PET

imaging but cardiac imaging for myocardial viability

will begin in mid 2003.

The Heart Failure/Cardiac Transplantation program

opened a new facility on the APC fifth floor.

THE MIRIAM HOSPITAL

Dr. Alfred Parisi retired in June of 2002 as Chief of

Cardiology and Division Director at Brown after 14

years in this position. He will remain active on the

faculty and on The Miriam Hospital staff focusing his

efforts on house staff and fellow education.

As of July 1, 2002 Dr. Ken Korr was named Chief of

Cardiology at The Miriam Hospital.

Dr. Paul Gordon serves as the Coronary Care Unit

Director. His role here ties in well with the evolution

of cardiac services at The Miriam

Hospital since so many CCU

patients at The Miriam are

received in transfer from outlying

facilities in need of interventional

cardiac procedures. Dr. Gordon is

also Director of Interventional

Cardiac Research at the hospital

and continues to be very active in

this area.

Dr. Gary Katzman completed his

first year as Associate Director of

the Coronary Care Unit after

joining The Miriam Hospital

based staff.

CARDIOLOGY FELLOWSHIPS

The two Cardiovascular fellowship training

programs are now joined into a single program with

a single match list for 6 fellows for 2004. There will

be 18 clinical fellows in the new combined program

with 6 fellows per year. Fellows will rotate through

three hospitals- RIH, TMH and the Providence

VAMC. In addition to the clinical track there will

continue to be a program for fellows interested in EP

that will include 2 years in the clinical program and 2

years as EP fellows. At the end of the 4 years they will

be eligible to take the boards in CVD and the

subspecialty boards in EP. There will also be a physi-

cian scientist track that will allow fellows interested

in pursuing a career in academic cardiology to take 2

years as clinical fellows and 2 years of research that

will allow them the opportunity to submit a K grant

for independent funding during the fourth year.

Kenneth Korr, M.D., Associate

Professor of Medicine; Director,

Division of Cardiology, The

Miriam Hospital

C A R D I O L O G Y

Faculty Members

FULL-TIME FACULTY(Hospital or Foundation Based)

Eric Berger, M.D., Clinical Assistant Professor, RhodeIsland Hospital, University Cardiology Foundation

David Brill, M.D., Clinical Assistant Professor,University Cardiology Foundation

Douglas Burtt, M.D., Clinical Assistant Professor,Miriam Hospital, University Cardiology Foundation

Alfred Buxton, M.D., Professor, Rhode Island Hospital,University Cardiology Foundation

Chester Chmielewski, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Fredric Christian, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Thomas Drew, M.D., Clinical Associate Professor,Rhode Island Hospital, University CardiologyFoundation

Jonathan Elion, M.D., Associate Professor, MiriamHospital

Kristen Ellison, M.D., Assistant Professor, Rhode IslandHospital, University Cardiology Foundation

Michael Gilson, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Paul Gordon, M.D., Clinical Assistant Professor, MiriamHospital, University Cardiology Foundation

Ned Gutman, M.D., Clinical Assistant Professor, MiriamHospital, University Cardiology Foundation

Lynne Johnson, M.D., Professor, Rhode Island Hospital,University Cardiology Foundation

Gary Katzman, M.D.,Clinical Assistant Professor,Miriam Hospital, University Cardiology Foundation

Edward Keating, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Malcolm Kirk, M.D., Assistant Professor, Rhode IslandHospital, University Cardiology Foundation

Kenneth Korr, M.D., Director, Associate Professor,Miriam Hospital, University Cardiology Foundation

Jon Lambrecht, M.D., Clinical Assistant Professor,Miriam Hospital, University Cardiology Foundation

Jeffrey Leavitt, M.D., Assistant Professor, MemorialHospital

Daniel Levine, M.D., Clinical Assistant Professor, RhodeIsland Hospital, University Cardiology Foundation

PATIENT CARE AREAS

CCU/ICU: The Miriam Hospital opened a new

CCU/ICU in July, 2002. The CCU is a nine bed unit

with individual rooms and the ICU is a 14 bed unit.

There are 5 swing beds. House staff sleeping quar-

ters, conference room space and a family consulta-

tion area were included in this large renovation.

Cardiac catheterization laboratory: Under the

direction of Dr. Ken Korr, interventional cardiac

procedures remain at an all time high, approxi-

mately 1500/year. Brachytherapy was added as an

additional modality to treat in-stent restenosis. The

lab is completely digital with the installation of the

Heartlab system. Workstations in the CCU, 4 East

and in the Fain Building facilitate patient care and

are a resource for teaching house staff. Several

ongoing interventional research projects continue.

Plans for an updated third cath lab, new

hemodynamic monitors and computerized cath

reports are being implemented.

Echocardiography Laboratory: Through Dr.

Sadaniantz’s efforts, the echo lab continues to be

highly productive with a large case volume of 2D

echo’s and an increasing volume of TEE’s and Stress

echo’s. A revised daily Fellow’s teaching schedule

has been implemented with fulltime faculty. A full-

time secretary is on site, allowing sonographers to

devote time exclusively to studying patients. Mr.

Marc Couturier was appointed as lead sonographer.

There is now sufficient staff so that Saturday studies

are offered routinely. Digital echocardiography has

been implemented with the Heartlab system. A new

echo reporting system is being trialed. 3D echo

capabilities are anticipated later this year.

Nuclear Cardiology: Under the direction of Dr.

Tilkemeier, this area performs in excess of 2500

studies per year. The laboratory has been accredited

through the American Society of Nuclear

Cardiology. There are daily Fellow reading sessions

with Dr. Tilkemeier.


Christopher Luttmann, M.D., Clinical AssistantProfessor, Miriam Hospital, University CardiologyFoundation

George McKendall, M.D., Associate Professor, RhodeIsland Hospital, University Cardiology Foundation

Gregory Michaud, M.D., Assistant Professor, RhodeIsland Hospital, University Cardiology Foundation

Albert S. Most, M.D., Director, Professor, Rhode IslandHospital, University Cardiology Foundation

Alfred Parisi, M.D., Director, Professor Emeritus,Miriam Hospital, University Cardiology Foundation

Athena Poppas, M.D., Assistant Professor, Rhode IslandHospital, University Cardiology Foundation

Roger Raymond, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Raymon Riley, M.D., Clinical Professor Emeritus,Rhode Island Hospital, University CardiologyFoundation

Ara Sadaniantz, M.D., Associate Professor, MiriamHospital, University Cardiology Foundation

Barry Sharaf, M.D., Associate Professor, Rhode IslandHospital, University Cardiology Foundation

Satish Sharma, M.D., Associate Professor, VA MedicalCenter

Alan Shurman, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

Katharine Stansmore, M.D.,Clinical Instructor, RhodeIsland Hospital, University Cardiology Foundation

Philip Stockwell, M.D., Clinical Assistant Professor,Miriam Hospital, University Cardiology Foundation

Peter Tilkemeier, M.D., Associate Professor, MiriamHospital, University Cardiology Foundation

Marilyn Weigner, M.D., Clinical Assistant Professor,Rhode Island Hospital, University CardiologyFoundation

David Williams, M.D., Professor, Rhode Island Hospital,University Cardiology Foundation

Wen-Chih Wu, M.D., Assistant Professor, VA MedicalCenter

VOLUNTEER FACULTY

Moses Aboagye-Kumi, M.D., Clinical AssistantProfessor, Miriam Hospital

Gilbert Altongy, M.D., Clinical Assistant Professor,Memorial Hospital

M. Wajid Baig, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Anthony Cannistra, M.D., Clinical Assistant Professor,Memorial Hospital

Lauralyn Cannistra, M.D., Clinical Assistant Professor,Memorial Hospital

Frank Capizzo, M.D., M.S., Clinical Assistant Professor,Rhode Island Hospital

FACULTY TRANSITIONS

Departing FacultyName Former PositionDavid Brill, M.D. Clinical Assistant Professor, Miriam HospitalRichard Carleton, M.D. Professor Emeritus, Memorial HospitalRobert Golub, M.D. Clinical Assistant Professor, Miriam HospitalTumkur Kumar, M.D. Clinical Assistant Professor, Memorial HospitalJeffrey Latham, M.D. Clinical Instructor,Roger Williams Medical CenterJeffrey Leavitt, M.D. Assistant Professor, Memorial HospitalRobert Perdoncin, M.D. Clinical Assistant Professor,VAMCCharles Rogers, M.D. Clinical Assistant Professor, Miriam Hospital

New FacultyName Former Position Faculty Rank

Kristen Ellison, M.D. Instructor, Harvard Medical School Assistant ProfessorPeter Gibson, M.D. Fellow, Brown Medical School Clinical InstructorGary Katzman, M.D. Fellow, Brown Medical School Clinical Assistant ProfessorShafiq Mamdani, M.D. Fellow, Yale School of Medicine Clinical InstructorMitchel Sklar, M.D., FACC Partner, North Texas Heart Center Clinical InstructorKatharine Stansmore, M.D. Fellow, Beth Israel Deaconess Medical Center Clinical InstructorPhilip Stockwell, M.D. Fellow, Columbia University Clinical Assistant ProfessorWen-Chih Wu, M.D. Fellow, Brown Medical School Assistant Professor

C A R D I O L O G Y

Robert Carnevale, M.D., Clinical Assistant Professor,Rhode Island Hospital

David Fortunato, M.D., Clinical Assistant Professor, VAMedical Center

Joseph Gaeta, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Carol Garber, Ph.D., Clinical Associate Professor,Memorial Hospital

Peter Gibson, M.D., Clinical Instructor, MemorialHospital

Robert Golub, M.D., Clinical Assistant Professor,Miriam Hospital

Suhdong Hahn, M.D., Clinical Assistant Professor,Memorial Hospital

Andrew Hordes, M.D., Clinical Associate Professor,Memorial Hospital

Jack Klie, M.D., Clinical Assistant Professor, MiriamHospital

Tumkur Kumar, M.D., Clinical Assistant Professor,Memorial Hospital

Kenneth LaBresh, M.D., Clinical Associate Professor,Roger Williams Medical Center

Jeffrey Latham, M.D., Clinical Instructor, RogerWilliams Medical Center

William Levin, M.D., Clinical Associate Professor,Miriam Hospital

Shafiq Mamdani, M.D., Clinical Instructor, MemorialHospital

James Mancini, M.D., Clinical Assistant Professor,Rhode Island Hospital

Richard Mead, M.D., Clinical Associate ProfessorEmeritus, Rhode Island Hospital

Robert Meringolo, M.D., Clinical Assistant Professor,Miriam Hospital

Thomas Noonan, M.D., Clinical Assistant Professor,Memorial Hospital

Robert Perdoncin, M.D., Clinical AssistantProfessor,VAMC

Arthur Phillips, M.D., Clinical Assistant ProfessorEmeritus, Memorial Hospital

Barbara Roberts, M.D., Clinical Associate Professor,Miriam Hospital

Charles Rogers, M.D., Clinical Assistant Professor,Miriam Hospital

Gisele Saliba, M.D., Clinical Assistant Professor, MiriamHospital

Franklin Schneider, M.D., Clinical Instructor, MiriamHospital

Robert Schwengel, M.D., Clinical Assistant Professor,Miriam Hospital

Richard Shulman, M.D., Clinical Associate Professor,Miriam Hospital

Mitchel Sklar, M.D., FACC, Clinical Instructor, MiriamHospital

Joseph Spinale, D.O., Clinical Instructor, MiriamHospital

Joseph Terlato, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Edward Thomas, M.D., Clinical Assistant Professor,Rhode Island Hospital

ADJUNCT FACULTY

David DeNofrio, M.D., Adjunct Assistant Professor,Rhode Island Hospital

Vilma Torres, M.D., Adjunct Clinical AssociateProfessor, Miriam Hospital

National andInternational Honorsand Recognitionof Faculty

Alfred E. Buxton, M.D.• Associate Editor, The American Journal of Cardiology

Editorial Boards:

• Journal of Cardiovascular Electrophysiology

• Journal of American College of Cardiology

Invited Presentations:

• Heart Failure Society of America – 5th AnnualScientific Meeting – “Prevention of Sudden Death inPatients with Heart Failure-Evidence from RecentClinical Trials”, Washington, DC

• North American Society of Pacing andElectrophysiology, 23rd Annual Meeting – CoreCurriculum – Update on Clinical Trials – “TheMUSTT Study – Recent Substudies”, San Diego, CA

• North American Society of Pacing and Elec-trophysiology, 23rd Annual Meeting – FeaturedSymposium – Impact of Device Therapy on theManagement of Patients with VentricularArrhythmias – “Lessons from Primary PreventionTrials in Patients with Coronary Artery Disease”, SanDiego, CA

• 11th International Congress on CardiovascularPharmacotherapy – “Management of VentricularArrhythmias”, Montreal, Canada


Kristin Elizabeth Ellison, M.D.Invited Presentations:

• Northeastern University Cardiovascular PerfusionCourse – “Antiarrhythmic Drugs”, Boston, MA

Paul C. Gordon, M.D.• Certificate of Completion, Novoste Beta-Cath System

Lynne L. Johnson, M.D.• Founding Member, American Society of Nuclear

Cardiology

• Member, Research Grants Committee for ASNC

• Appointed as Co-Chair of the Research Grants Com-mittee for American Society of Nuclear Cardiology

• Appointed to serve on Program Committee forannual national meeting of ASNC for 2003

• Appointed to serve on Spotlight Program Committeefor American College of Cardiology annual meetingin 2004

• Appointed to serve another four year term on theDiagnostic Imaging Study Section at the NHLBI

• Appointed Chair Brown University Department ofMedicine Tenure and Promotions Committee

Editorial Boards:

• American Heart Journal

• Journal of American College of Cardiology

• Abstract reviewer for annual scientific sessions ofAmerican Heart Association and Society of NuclearMedicine and American College of Cardiology,International Congress of Nuclear Cardiology I, II, III

• Abstract grader for Society of Nuclear Medicine,American Society of Nuclear Cardiology andAmerican College of Cardiology

• Co-chairperson for original paper sessions for annualscientific sessions of American Heart Association,American College of Cardiology, and Society ofNuclear Medicine

• Manuscript reviewer for Circulation, Journal ofNuclear Medicine, American Journal of Cardiology,Journal of the American College of Cardiology,American Journal of Medicine


• Invited speaker at the Annual Meeting of the Portu-guese Heart Association Algarve Portugal May 2002

• Invitational Meeting ASNC Lake Tahoe CA July 2002

• Invited speaker Nuclear Medicine Seminar at HarvardUniversity Nov 2002,

• Invited speaker Sixth International Congress ofNuclear Cardiology Florence Italy April 2003.

Kenneth S. Korr, M.D.• Secretary/Treasurer: Rhode Island Chapter of the

American College of Cardiology

• Certificate of Completion, Novoste Beta-Cath System

• Voted Top 10 Cardiologists in Rhode Island, RhodeIsland Monthly

George R. McKendall, M.D.• Member, Board of Governors Steering Committee,

American College of Cardiology

• Member, Board of Governors Working Group onState and Federal Advocacy, American College ofCardiology

• Member, Nominating Committee, American Collegeof Cardiology

• Member, Cardiac Catheterization and InterventionCommittee, American College of Cardiology

• Council Member, Rhode Island Chapter of theAmerican College of Cardiology

• Chairman, Annual Meeting and Education Commi-ttee, Rhode Island Chapter of the American Collegeof Cardiology

• Abstract Grader, American College of Cardiology 52nd

Annual Scientific Session

• Abstract Grader, International Symposium ofTranscatheter Cardiovascular Therapeutics (TTC)14th Annual Session

• Abstract Grader, International Symposium ofTranscatheter Cardiovascular Therapeutics (TTC)15th Annual Session

• Relevance Reviewer for Cardiovascular Disease,American Board of Internal Medicine

• American College of Cardiology 49th Annual Scien-tific Session, Invited Lecturer: Cardiogenic ShockWithout Mechanical Defects: Nonsurgical Therapies

Alfred Parisi, M.D.• Selected for listing in “Best Doctors”

• Associate Editor, American College of CardiologyCurrent Review Journal

Athena Poppas, M.D.• Member, NHLBI-BARI 2D Steering Committee,

Working Group–Cardiovascular Pharmacological andHypertension Management

• Executive Council and Chairperson, EducationCommittee, American College of Cardiology, RhodeIsland Chapter

• Abstract Reviewer and Program Moderator, AmericanSociety of Echocardiography, American College ofCardiology

C A R D I O L O G Y

• Abstract Reviewer/Program Moderator, ScientificSessions, American Heart Association

• Manuscript Reviewer, Journal of the American Societyof Echocardiography, American Heart Journal

• Reviewer, Intersociety Commission for theAccreditation of Echocardiography Laboratories

• American Society of Echocardiography: Women’sHealth Advisory Group, Membership SteeringCommittee

• Governor-elect for RI American College ofCardiology

• Women in Cardiology Committee of the AmericanCollege of Cardiology

• Allied Health Professionals Committee of theAmerican College of Cardiology


• Heart Disease in Women, ACP-ASIM InternalMedicine Update, Newport, Rhode Island

Ara Sadaniantz, M.D.• Guest editor for special section in journal

Echocardiography

• Section editor for the new column in cardiovascularreviews and reports dealing with innovative andunusual therapies in cardiovascular medicine

Barry L. Sharaf, M.D.Editorial Boards:

• Journal of the American College of Cardiology

• Coronary Artery Disease

• American Journal of Managed Care


• Coronary Angiography. American Heart AssociationScientific Conference on Molecular, Integrative, andClinical Approaches to Myocardial Ischemia.Women’s Ischemia Syndrome Evaluation (WISE)Workshop. Seattle, Washington

• Are We Making Any Progress in the Diagnosis andTherapy of Cardiovascular Disease in Women?Findings from the NHLBI-Sponsored Women’sIschemia Syndrome Evaluation (WISE) Study.Cardiology Grand Rounds, Einstein Hospital, Bronx,New York

• Coronary Angiography. Residency Conference, RhodeIsland Hospital, Providence, RI

• Emergency Management of Acute MyocardialInfarction. Cardiology Grand Rounds, SturdyMemorial Hospital, Attleboro, Mass.

Peter L. Tilkemeier, M.D.• Masters of Medical Management, Carnegie-Mellon

University

• Member, National Pharmacy and Therapeutics Com-mittee, CIGNA Healthcare, and LaboratoryAccreditation Committee for Nuclear Cardiology

Invited lecturer:

• International Symposium on Cardiovascular NuclearMedicine, Beijing, China

David O. Williams, M.D.Editorial Boards:

• American Heart Journal

• Circulation

• Interventional Cardiology

• ACCEL Editorial Board

• American Journal of Medicine


• Editorial Consultant, The Medical Letter

Editorial Review

• Annals of Internal Medicine

• Chest

• Circulation


• Journal of Thoracic and Cardiovascular Surgery

• New England Journal of Medicine

Steering committees, program committees:

• Member, American Board Internal Medicine,Interventional Cardiology Test Committee

• Chairman, Angioplasty Sub-committee, MarylandHealth Care Commission

• Program Committee and Speaker: Scientific SessionsAmerican Heart Association

• Member, ACC/AHA Guidelines Committee forCoronary Angioplasty


• Invited speaker for Scientific Sessions AmericanCollege of Cardiology, Transcatheter Therapeutics,ACC Cardiology at Snowmass


Research and OtherScholarly Activities

FACULTY MEMBERS OF STUDYSECTIONS AND ADVISORY COMMITTEES

Alfred E. Buxton, M.D.• Member, National Advisory Panel to NIH CARD

PORT “Sudden Cardiac Death” – Stanford UniversitySchool of Medicine, Mark Hlatky, PrincipalInvestigator

• Committee Membership of the American College ofCardiology: ACC/AHC/ACP-ASIM Committee toRevise the 1995 Statement on Electrocardiography

Paul C. Gordon, M.D.• Clinical Research Review Board, The Miriam Hospital

• Blue Cross/Blue Shield of Rhode Island CardiologyAdvisory Committe

Lynne L. Johnson, M.D.• Consultant for Therox, Inc., Irvine, CA

• Lifespan Research Advisory Committee

• Editorial Board: Journal of American College ofCardiology

• Member NHLBI Diagnostic Imaging Study Section(second term)

• Program Committee for ASNC National Meeting2003

• Program Committee for Spotlight Sessions AmericanCollege of Cardiology Meeting 2004

• Co-chair Research Grants Committee ASNC

George R. McKendall, M.D.• Editorial and Advisory Board, The Journal of

Thrombosis and Thrombolysis

• Reviewer, Catheterization and CardiovascularDiagnosis

• Member, Steering Committee, Double-Blind, Ran-domized, Multicenter Trial of Single-Bolus Lano-teplase vs. Accelerated Alteplase for the Treatment ofSubjects with Acute Myocardial Infarction (In TimeII, a multicenter international trial)

• Abstract Grader, American Heart Association 71st,72nd, 73rd Scientific Sessions (three year term)

• Member, Occluded Artery Trial (OAT) Mortality andMorbidity Classification Committee

Gregory Michaud, M.D.Manuscript Reviewer:

• Journal of Cardiovascular Electrophysiology

• Journal of Interventional Cardiac Electrophysiology

• Circulation

• Lancet

• Pacing and Clinical Electrophysiology

Alfred Parisi, M.D.Azithromycin Coronary Events Study (ACES)

• Chairman, Steering Committee

• Member, Executive Committee

• Member, Events Committee

Athena Poppas, M.D.• Abstract Reviewer and Program Moderator, American

Society of Echocardiography

• Annual Scientific Sessions

• Abstract Reviewer and Session Moderator, AmericanCollege of Cardiology

• Manuscript Reviewer, Journal of the American Societyof Echocardiography

• Manuscript Reviewer, American Heart Journal

• Member, NHLBI-BARI 2D Steering Committee,Working Group – Cardiovascular Pharmacologicaland Hypertension Management

• Scientific Sessions Abstract Reviewer/ProgramModerator, American Heart Association

• Reviewer, Intersociety Commission for theAccreditation of Echocardiography Laboratories

• American Society of Echocardiography:Women’s Health Advisory GroupMembership Steering Committee

• Member Lifespan IRB committee

• Course co-director Cardiology for the Primary CareProvider, RI Chapter of ACC

Barry L. Sharaf, M.D.• Member, Steering Committee, Bypass Angioplasty

Revascularization Investigation (BARI), NationalHeart, Lung and Blood Institute

• Member, Women’s Ischemic Syndrome Evalution(WISE), Operations Committee, National Heart,Lung and Blood Institute

• Chapter Author, American College of Cardiology,Cardiac Catheterization and Coronary InterventionSelf Assessment Program (CathSAP)

• Chairman, AVI Biopharma DSMB, Eminent Research

Peter L. Tilkemeier, M.D.• Moderator, Scientific Sessions, Society of Nuclear

Medicine Annual Meeting

• Abstract Reviewer, American College of ChestPhysicians, Annual Scientific Meeting

C A R D I O L O G Y

David O. Williams, M.D.• Board Member, American Board of Internal

Medicine, Interventional Cardiology Test Committee

• Member, American Federation of Clinical Research

National Heart, Lung and Blood InstituteCommittees:

The Registry for Percutaneous TransluminalCoronary Angioplasty

Member, Executive Committee

Member, Steering Committee

• Data, Safety and Monitoring Committee:

Should We Emergently Revascularize OccludedCoronaries For Cardiogenic Shock

• Veterans Administration Research Service

Data, Safety and Monitoring Committee –CSP #267

Percutaneous Coronary Angioplasty (PTCA), TheACME Trial

National Committees:

• American College of Cardiology

• Coding and Nomenclature Committee

• Economics of Health Care Delivery Committee

• Cardiac Catheterization Committee, 1998-2004,Chair, 2002-2004

• ACC Career Development Awards Competition inAcute Coronary Syndromes

• Member, Cardiac Care Advisory Committee for theRhode Island State Department of Health

Advisory Boards or Committees:

• Thrombolysis in Myocardial Infarction Trial (TIMI)(NO1 HV38023)

• National Heart, Lung and Blood InstituteMember, Steering CommitteeChairman, Subcommittee on Acute CatheterizationMember, Executive CommitteeMember, Forms CommitteeChairman, Committee on Coronary Angioplasty

• Bypass Angioplasty Revascularization Investigation(BARI) (5 UO1 HL38532)

• National Heart, Lung and Blood Institute, PrincipalInvestigator

Member, Steering CommitteeMember, Executive CommitteeChairman, PTCA CommitteeMember, Analysis CommitteeMember, Operations Committee

TEACHING ACTIVITIESEDUCATION HONORS

Alfred Parisi, M.D.• Teacher of The Year, Brown Medical School, Com-

bined Cardiovascular Diseases Fellowship Program

David O. Williams, M.D.• Dean’s Teaching Excellence Award. In recognition of

exemplary teaching in Bio 301: Clerkship in Medicine

Ara Sadaniantz, M.D.• Best Teacher Award presented by 2002 Cardiology

Fellows

Hank Wu, M.D.• Best Teacher Award, TMH, presented by 2003

Cardiology fellows

TEACHING RESPONSIBILITIES

Douglas Burtt, M.D.• Dr. Burtt continues in his leadership of BioMed 281,

Introduction to Cardiovascular Pathophysiology. Itremains one of the most popular segments of thissecond year medical school course.

Alfred Buxton, MD• Program Director, Electrophysiology Fellowship

Lynne Johnson, MD• Program Director, Combined Program in

Cardiovascular Disease Fellowship

Kenneth S. Korr, M.D.• Lecturer, Biomed IMS-281 – Valvular Heart, Brown

Medical School

• “Treating Heart Disease in Women: The LatestInterventions”–Women’s Wellness Workshop

• Program Director, Interventional CardiologyFellowship, The Miriam Hospital

• Miriam Hospital Noon Conf.: Ischemic Heart Disease

George McKendall, MD• Director, CCU Rotation, Rhode Island Hospital

Albert S. Most, M.D.• Basic electrocardiography for third year medical

students on medical clerkships

Peter L. Tilkemeier, M.D.• Program Director, Combined Program in Cardiovas-

cular Disease Fellowship

David Williams, MD• Program Director, Interventional Cardiology

Fellowship, Rhode Island Hospital

Hank Wu, M.D.• Co-section leader


CARDIOLOGY FELLOWSHIP PROGRAMDeparting Fellows — Rhode Island Hospital

Name Medical School Residency Post Graduate PlansInterventional CardiologyMichael Berlowitz, M.D. University of Michigan Emory University Rochester General Hospital

Medical School Affiliate HospitalSteven Lee, M.D. Brown Medical School Brown Med. Sch., Internal Med. Southwest Florida Heart GroupGeneral CardiologyJon C. Gaudio, M.D. Albert Einstein College University of Colorado Eastern Connecticut Cardiology

Of Medicine Health Science Center GroupBrian A. Hanlon, M.D. SUNY – Buffalo Brown Med. Sch., Internal Med. Southwest Florida Heart GroupAlice Y. Kim, M.D. SUNY – Syracuse Brown Med. Sch., Internal Med. Albany Associates in CardiologyKeith A. Landesman, M.D. University of Connecticut Brown Med. Sch., Internal Med. The Heart Physicians, Stamford, CT

Current Fellows — Rhode Island Hospital

Name Medical School ResidencyGeneral Cardiology FellowsEdward J. Choi, M.D. Wake Forest University School of Medicine UMDNJ-Robert Wood JohnsonMark C. Heckel, M.D. Temple University School of Med. Rhode Island Hospital/ The Miriam HospitalJamie H. Kim, M.D. Tufts University School of Medicine New England Medical CenterMaria T. Anderson, M.D. Tufts University School of Medicine Travis Air Force BaseGeorge G. Scleparis, M.D. Tufts University School of Medicine University of Massachusetts Medical CenterLinda G. Yan, M.D. University at Buffalo School of Medicine University Hospital at Stony Brook

ElectrophysiologyBryan H. Frain, M.D. Tulane University School of Medicine Medical University of South Carolina

Fellow: University of South CarolinaCharles Koo, M.D. SUNY – Stony Brook Beth Israel Deaconess Hospital

Departing Fellows — The Miriam Hospital

Name Medical School Residency Post Graduate PlansDavid Bailey, M.D. Univ. College London Yale University Interventional Cardiology

Medical SchoolManoj K. Eapen, M.D. Trivandrum Med. School, Brown Medical School Private Practice in MO

Kerala University, IndiaJocelyn Fernandez, M.D. Univ. of the Philippines State Univ. of NY UPMC – Academic

College of Medicine Health Science CenterJohn V. Golding, M.D. Meharry Medical College Washington Hospital Center Interventional CardiologyNaji Hamdan, M.D. Howard University St. Vincent Hospital Private Practice in Oregon

School of MedicineSameh N. Khouzam, M.D.Ain Shams Univ., Cairo, Egypt Cleveland Clinic EP Fellowship at RIHH. David Lu, M.D. Northwestern University Baylor College of Medicine Private Practice in MA

Medical SchoolG. Mark Tussey, M.D. University of Kentucky University of Virginia Private Practice in KentuckyVikas Verma, M.D. All India Institute of Medical Marion Memorial Hospital Private Practice in Florida

Sciences, New Delhi, IndiaWen-Chih Wu, M.D. Univ. of Costa Rica, Univ. of Connecticut VA Medical Center, Providence, RI

San Jose, Costa Rica School of Medicine – Academic

Current Fellows — The Miriam Hospital

Name Medical School ResidencyGeorge Aziz, M.D. Medical College of Ohio Loyola University Medical CenterJanak H. Bhavsar, M.D. UMDNJ – New Jersey Medical School Mayo ClinicDaniel E. Guralnick, M.D. University of Alabama Virginia Mason Medical CenterLinda A. Ireland, M.D. Philadelphia College of Osteopathic Med. Lehigh Valley HospitalAndrew A. Nowak, M.D. UMASS Medical School UMASS Medical CenterPranav M. Patel, M.D. St. Louis University Case Western Reserve UniversityKai Sung, M.D. Columbia Univ. of Physicians & Surgeons Baylor College of MedicineJohn W. Waggoner, M.D. Oregon Health Sciences University University of Vermont/FAHC

C A R D I O L O G Y

SMALL GROUP FACILITATORS

Daniel Levine, M.D.

Hank Wu, M.D.

Ara Sadaniantz, M.D.• Course Leader, BioMed 217 – Echocardiography

Lab, Cardiovascular physiology course

• Lecturer, echocardiography and cardiac physiology

• Live demonstration of echocardiography

Chi-Ming Hai, Ph.D.• Course Director

SELECTED PUBLICATIONS

Alfred E. Buxton, M.D.• Pires LA, Hafley GE, Lee KL, Fisher JD, Josephson

ME, Prystowsky EN, Buxton AE, for the MulticenterUnsustained Tachycardia Trial Investigators. Signifi-cance of Nonsustained Ventricular Tachycardia Iden-tified Postoperatively after Coronary Bypass Surgeryin Patients with Left Ventricular Dysfunction. JCardiovasc Electrophysiology. 2002;13:757-763.

• Buxton AE, Hafley GE, Lee KL, Gold MR, Packer DL,Lehmann MH, Josephson ME, Wyse DG, Fisher JD,Prystowsky EN, Talajic MR, Pires LA, for theMUSTT Investigators. Relation of Ejection Fractionand Inducible Ventricular Tachycardia to Mode ofDeath in Patients with Coronary Artery Disease. AnAnalysis of Patients Enrolled in the MulticenterUnsustained Tachycardia Trial. Circulation2002;106:2466-2472.

• Ellison KE, Hafley GE, Hickey K, Kellen J, CoromilasJ, Stein KM, Lee KL, Buxton AE, for the MUSTTInvestigators. Effect of -blocking Therapy onOutcome in the Multicenter UnSustainedTachycardia Trial (MUSTT). Circulation.2002;106:2694-2699.

Lynne L. Johnson, M.D.• Kroll D, Farah W, McKendall GR, Reinert SE,

Johnson LL. Prognostic Value of Gated Tc-99Sestamibi SPECT Post Myocardial Infarction. Am JCardiol 2001; 87(4):381-386.

• Gibson PB, Demus D, Noto R, Hudson W, JohnsonLL. Low Event Rate for Stress-Only PerfusionImaging in Patients Evaluated for Chest Pain. JACC2002; 39(6):999-1004.

• Johnson LL, Thambar S, Donahay T, Dae M,Williams DO. Effect of Endomyocardial LaserChannels on Regional Innervation Shown with(125)I-MIBG and Autoradiography. J Nuc Med 2002;43(4):551-555

• Thambar ST, Schofield L, Poppas A, Bouchard M,Johnson LL. Validation of R wave voltage Endomyo-cardial Mapping to Assess Myocardial ViabilityAgainst Myocardial Fibrosis- Comparison withThallium and Dobutamine Echocardiography in aSwine Model. J Interv Cardiol 2003, 16(1):23-31.

• Johnson LL, Schofield LM, Weber DK, Virmani R,Khaw BA. Uptake of Indium-111 Z2D3 on SPECTImaging in a Swine Model of Coronary StentRestenosis Correlated with Cell Proliferation. J NucMed (in press)

Malcolm Moore Kirk, M.D.• Kirk, M., Shorofsky, S., Gold, M. Comparison of the

effects of active left and right pectoral pulsegenerators on defibrillation efficacy. American Journalof Cardiology. 2001; 88(11): 1308-11

• Rashba EJ. Cooklin M. MacMurdy K. Kavesh N. KirkM. Sarang S. Peters RW. Shorofsky SR. Gold MR.Effects of selective autonomic blockade on T-wavealternans in humans. Circulation. 2002; 105(7):837-42.

• Kirk, M.M., Izu, L.T., Chen-Izu, Y., McCulle, S.L.,Wier, W.G. Balke, C.W., Shorofsky, S.R. Role of theTransverse-Axial Tubule System in GeneratingCalcium Sparks and Calcium Transients in Rat AtrialMyocytes. Journal of Physiology 2003; 547.2, 441-451.

• Kirk, M., Michaud, G., Badger, D., Pezzullo, E.Baptista, K., Ricci, R.M. Renaud, D., Hurst, J., Miele,S., Buxton, A. The Use of Head-up Tilt to FacilitateInduction of Atrioventricular Nodal ReentrantTachycardia. Pacing and Cardiac Electrophysiology2001, 24, part II, A676

• Frain, B H., Ellison, K. E., Michaud, G. F., Gibbs M.E., Koo C. H., Gandhi G. D., Khouzam S., Buxton A.E., Kirk, M. M. True Bipolar Defibrillator Leads HaveIncreased Threshold and Sensing Latency Comparedto Integrated Bipolar Configuration. Pacing andCardiac Electrophysiology 2003, 26(4), part II, A331

Kenneth S. Korr, M.D.• Sadaniantz A, Korr, KS: Neurologic Event, Mitral

Valve Mass and Fibroelastoma in a Young Patient :Cardiovascular Reviews and Reports Publication 2003.

• Korr KS: Guest Editor-Drugs and Devices “10 YearsAfter”: Medicine and Health Rhode Island Vol. 84:36-37, 2001.

• Korr KS., Reitman A: Renal Implications ofPercutaneous Coronary Intervention: Seminars inNephrology Vol. 21, No. 1 36-46, 2001.

George R. McKendall, M.D.• Tolerico PH, McKendall GR: Femoral Endarteritis as

a Complication of Percutaneous CoronaryIntervention, Journal of Invasive Cardiology2000;12:155-157.


• Kroll D, Farah W, McKendall GR, Reinert S, JohnsonL: Prognostic Value of Stress-Gated Tc-99mSestamibi SPECT After Acute Myocardial Infarction.The American Journal of Cardiology 2001; 87(4):381-386.

• Baran KW, Nguyen M, McKendall GR, Lambrew CT,Dykstra G, Palmeri ST, Gibbons RJ, Borzak S, SobelBE, Gourlay SG, Rundle AC, Gibson CM, Barron HV:Double-Blind, Randomized Trial of an Anti-CD18Antibody in Conjunction with Recombinant TissuePlasminogen Activator for Acute MyocardialInfarction. Circulation 2001; 104(23): 2778-2783.

• Cannon CP, Bahit MC, Haugland JM, Henry TD,Schweiger MJ, McKendall GR, Shah PK, Murphy S,Gibson M, McCabe CH, Antman EM, Braunwald E:Underutilization of Evidence-Based Medications inAcute ST Elevation Myocardial Infarction. CriticalPathways in Cardiology 2002; 1(1):44-52.

• Henry TD, Annex BH, McKendall GR, Azrin MA,Lopez JJ, Giordano FJ, Shah PK, Willerson JT, BenzaRL, Berman DS, Gibson CM, Bajamonde A, RundleAC, Fine J, McCluskey ER: The VIVA Trial VascularEndothelial Growth Factor in Ischemia for VascularAngiogenesis. Circulation 2003; 107(10):1359-1365.

• Caron MF, McKendall GR: Bivalirudin: AnAntithrombotic in Percutaneous Coronary Inter-vention. American Journal of Health-SystemPharmacy; In Press.

Ara Sadaniantz, M.D.• Sadaniantz A. Introduction/editorial Cardiovascular

disease in renal patients. Seminars in Nephrology. 00-00 21:1-2, 2001.

• Fernandes J, Sadaniantz A. Use of low-molecular-weight heparin and glycoprotein IIb/IIIa inhibitors inacute coronary syndromes. Medicine and Health/Rhode Island. 84:37-43, 2001.

• Katz A, Sadaniantz A. Echocardiography in HIVcardiac Disease. Progress in Cardiovascular Disease.45:285-292, 2003.

• Sadaniantz A, Anastacio R Verma V, Aprahamian N.The incidence of diastolic right atrial collapse inpatients with pleural effusion in the absence ofpericardial effusion. Echocardiography. 20:211-217,2003.

• Bailey D, Sadaniantz A. Benzocaine-InducedMethemoglobinemia during a transesophagealechocardiogram; a case report and literature review.Cardiovascular review and reports. 24:264-266, 2003.

David O. Williams, M.D.• Williams DO, Detre K, Yeh W, Bentivoglio L, Bourassa

MG, Al-Bassam M, Block PC, Cohen H, Cowley M,Dorros G, Faxon D, Holmes DR, Holubkov R, JacobsA, Kelsey S, King, III SB, Myler R, Slater J, Stanek Vand Co-Investigators. Percutaneous coronaryintervention in the current era compared to 1985-86:The NHLBI Registries. Circulation 2000:102:2945-2951.

• Aversano T, Aversano LT, Passamani E, Knatterud G,Terrin ML, Williams DO, Forman SA, for the AtlanticCardiovascular Patient Outcomes Research Team (C-PORT). Thrombolytic therapy vs. primarypercutaneous coronary intervention for myocardialinfarction patients presenting to hospitals withouton-site cardiac surgery. A randomized controlledtrial. Journal of the American Medical Association2002;287(15):1943-1951.

• Williams, DO: Intracoronary Brachytherapy: Past,Present, and Future. Circulation 2002;105:2669-1700.

• Srinivas VS, Brooks MM, Detre KM, King, III SB,Jacobs AK, Johnston J, Williams DO: Contemporarypercutaneous coronary intervention versus balloonangioplasty for multivessel coronary artery disease. Acomparison of the National Heart, Lung, and BloodInstitute Dynamic Registry and the BypassAngioplasty Revascularization Investigation (BARI)Study. Circulation 2002;106:1627-1633.

• Thambar ST, Schofield L, Poppas A, Bouchard M,Williams DO, Johnson LL: Validation of R wavevoltage endomyocardial mapping to assess myocardialfibrosis: Comparison with thallium and dobutamine.Journal of Interventional Cardiology 2003;16:23-31.

C A R D I O L O G Y

BASIC RESEARCHLynne Johnson, M.D.

• Coronary Aqueous Oxygen Infusion Titration,TherOx, Incorporated

• Aqueous Oxygen Infusion Via Venous Route, TherOxIncorporated

• Imaging Apoptosis to Detect Unstable AtheromatousPlaque, MCP Hahnemann University/NIH

• Imaging Intimal Hyperplasia, Myocte Hypoxia,Necrosis, NIH/National Heart Lung & Blood Institute

• Optical Coherence Tomography in Coronary Imaging,Lightlab Imaging, LLC

• External Counterpulsation for Myocardial Infarction,University of Rhode Island

• Imaging Angiiogenesis in Chronic Hibernation, NIH/National Heart, Lung and Blood Instutute

CLINICAL RESEARCHAlfred Buxton, M.D.

• PainFREE RX II Extension Study, MedtronicsIncorporated

• InControl Metrix Automatic Atrial DefibrillationSystem Clinical Study, InControl Incorporated

• Fractal - Fibrillation Registry Assessing Costs,Therapies, Adverse Events and Lifestyle, Beth Israel/Medtronics Corporation

• Dual-Site Atrial Pacing to Prevent Atrial Fibrillation(DAPPAF) Clinical Trial, Medtronic Incorporated

• Sudden Cardiac Death in Heart Failure Trial, DukeUniversity/NHLBI

• Does Pacing Fast VT Reduce Shock Rx, MedtronicsIncorporated

• Atrial Fibrillation and Congestive Heart Failure,Research Centre of the Montreal Heart Institute

• Fatty Acid Antiarrythmia Trial (FAAT), MassachusettsGeneral Hospital/NHLBI

• MUSTT (Guidant), Guidant Corporation

• Swine Study CR Bard, C.R.Bard, Incorporated

• MUSTT (Medtronics), Medtronics Incorporated

• Identification of Protein Markers for Sudden CardiacDeath in VT/VF Patients, Medtronics Incorporated

Frederick Christian, M.D.

• Atrial High Rate Episodes in Pacemaker Patients,Medtronics Incorporated

Kristin Ellison, M.D.

• Synergistic Effects of Risk Factors for Sudden CardiacDeath, Guidant Corporation

• Hemodynamic Effects of Biventricular Pacing AfterOpen-Heart Surgery, Medtronics Incorporated

• Atrial Synchrononous Biventricular Pacing Device,Medtronics Incorporated

Paul Gordon, M.D.

• ICE-IT Trial, Innercool Therapies

• Palmaz-Schatz Crown Balloon Expandable StentMounted on the PowerGrip Over The Wire SDSStudy, Cordis (J&J)

• AIMI Study, Possis Medical

• Asteroid Study, AstraZeneca

• A Randomized Comparison of the ACS Multi-LinkStent with or Without Adjunctive Directional Coro-nary Atherectomy (DCA) In Treatment Of PatientsWith De Novo and Restenotic Native Coronary ArteryLesions, Advanced Cardiovascular Sys

• NIR Vascular Advanced North American System Trial,Medinol Ltd.

• PALMAZ-SCHATZ Mini-Crown Balloon ExpandableStent on the Dynasty DS Over-the-, Cordis (J&J)

• A Prospective, Randomized, Double Blind, Multi-center Study Comparing the Effects of Atorvastatinversus Pravastatin on the Progression andquantification of coronary Atherosclerotic Lesions asMeasured by Intravascular Ultrasound, Warner-Lambert Co/The Covalent Group

• SVG Registry, Metronic AVE

• A Randomized, Double-Blind Placebo-ControlledStudy of Two Intravenous Dosing Regimens ofh5G1.1-scF, Kendle International Inc.

• A Multicenter Study of 5-Year Follow-up for theCrossFlex LC Balloon-Expandable Stent Mounted onthe OTw Delivery System in Patients with De Novo orRestenotic Native coronary Artery Lesions, Cordis,Corp.

• Tenax XR Registry, BioTronik, Inc.

Direct Indirect Total

Total Basic Research Expenses Academic Year 2002 $306,255 $129,755 $436,010

Academic Year 2003 $292,114 $147,849 $439,963

Total Clinical Research Expenses Academic Year 2002 $687,278 $157,393 $844,671

Academic Year 2003 $698,237 $166,887 $865,124


• A Phase 2, Multicenter, Double-Blind, Placebo-Controled, Dose-Ranging Study to Evaluate theSafety and Efficacy of BP-653 in the Prevention ofPost Angioplasty Restenosis in Stented Lesions,Chugai Biopharm.

• A Prospective, Randomized, Open-label, MulticenterStudy in Patients Presenting with Acute CoronarySyndromes, Aventis Pharmaceuticals Products,Incorporated

• A Prospective, Randomized Trial Evaluating theTaxus Paclitaxel-Eluting Coronary Stent in De NovoCoronary Stent in De Novo Coronary Lesions andIn-Stent Restenosis, Parexel/BSC

• TriActiv System Randomized Multicenter ClinicalTrial, Kensey Nash Corporation

Lynne Johnson, M.D.

• Tc-99m Glucarate for Chest Pain Triage in EmergencyRoom - Phase II, Molecular Targeting Technologies

• Assessing the Prognostic Value of Gated SPECTUsing a Multihospital Nuclear Cardiology Database,Dupont Merck Pharmaceutical Company

• A Phase III Open Label Single Crossover Study toConfirm the Diagnostic Potential of IntravenouslyA, CIS-US, Incorporated

Malcolm Kirk, M.D.

• Alternans Before Cardioverter Defibrillator Trial,Pacesetter, Incorporated, a St. Jude Company

• Device Evaluation of CONTAK RENEWAL 2 andEASYTRAK 2: Assessment of Safety andEffectiveness in Heart Failure, Guidant Corporation

• The Effect of Omega-3 Fatty Acids on theElectrophysiology of Chronically Infarcted SwineHearts, Rhode Island Foundation

Kenneth Korr, M.D.

• Post-dilation Clinical Comparative Study (POSTIT),Boston Scientific Scimed, Inc.

• Left Main Intravascular Ultrasound (IVUS) Registry,Scripps Clinic

Daniel Levine, M.D.

• SPAN-CHF: A Lifespan Demonstration Project inDisease Management, New England Medical Center

• Study of Candesartan in Patients with Heart Failureand Preserved Left Ventricular Systolic Function,AstraZeneca

• Randomized Evaluation of IntravenousLevosimendan Efficacy Versus Placebo in the ShortTerm Treatment of Decompensated Chronic HeartFailure, M.D.S Pharma Services Incorporated

• The Coreg Heart Failure Registry: COHERE, SmithKline Beecham and Roche Pharmaceuticals

• Irbesartan in Heart Failure With Preserved SystolicFunction (I-Preserve), Bristol-Myers Squibb,Incorporated

• Omapatrilat Versus Enalapril in Heart Failure-Morbid-ity and Mortality Assessment, Bristol-Myers Squibb

• Selective Estrogen Receptor Modulation: Effects inPostmenopausal Women with Left VentricularDysfunction, NIH/New England Medical Center

• Can Automated Home Monitoring Reduce HeartFailure Hospital Utilization and Augment MedicationComnpliance Compared with Non-AutomatedConventional Disease Management?, New EnglandMedical Center

• Multicenter, Randomized Double Blind PlaceboControlled Efficacy Study on the Effects of OralTovalptan on Left Ventricular Dilation and Functionin Patients with Heart Failure and Left VentribularSystolic Dysfunction, Cardiovascular Clinical Studies,L.L.C./Otsuka

• An Open Label Prospective Parallel 6 Month Con-trolled Randomized Multicenter Trial Comparing theLong Term Safety of the ResMed AutoSet CS Com-pared to 2 L/min Nasal Oxygen, ResMed Corp

• Study of Candesartan in Patients with Heart FailureWho Treated with Ace Inhibitors and Have DepressedLeft Ventricular Systolic Function (SH-AHS-0006),AstraZeneca

• Study of Candesartan in Patients with Heart FailureWho are Ace Inhibitor Intolerant and Have DepressedLeft Ventricular Systolic Function (SH-AHS-0003),AstraZeneca

• A Phase II Multicenter Randomized Double BlindPlacebo Controlled Pilot Trial Evaluating the Effectsof Infliximab (Remicade) in Patients with Stable ClassIII or IV Congestive Heart Failure, CardiovascularClinical Studies, L.L.C./Centocor

George McKendall, M.D.

• A Prospective, Randomized, Open-Label, MulticenterStudy in Patients Presenting With Acute Syndromes,Aventis Pharmaceuticals Products, Incorporated

• Perfusion by Thrombolytic and UltraSound, HenryFord Coordinating Center

• Magnesium in Coronaries-A Study of the Effect ofMagnesium Administration in Patients with AcuteMycardial Infarction, New England Research Institute,Incorporated/NIH

• A Prospective Randomized Trial of PrimaryAngioplasty Versus Thrombolytic Therapy for AcuteMycardial Infarction, William Beaumont Institution

• Exoraparin and TNK-tPA with or without GPIIbInhibitor as Reperfusion Strategy in ST El, Rhone-Poulenc Rorer

• A Randomized, Double-Blind Placebo-ControlledStudy of Two Intravenous Dosing Regimens, Procter& Gamble Pharmaceuticals, Inc.

• A Multicenter Randomized Controlled Double BlindTrial to Investigate the Clinical Efficacy andtolerability of Early Treatment with Simvastatin 40 mg

C A R D I O L O G Y

Daily for 30 days, followed by Simvastatin 80 mgDaily Thereafter in Tirofiban-Treated AcuteCoronary Syndrome Patients Who have been Ram-domized to Receive Enoxaparin or UnfractionatedHeparin in Conjunction with Aspirin A to Z, Merck/Brigham and Women’s Hospital

Gregory Michaud, M.D.

• Comparison of Medical Therapy, Pacing and Defi-brillation in Heart Failure, Guidant Corporation

• Dual Chamber and VVI Implantable DefibrillatorTrial, University of Washington/Pacesetter

• Contak CD Heart Failure Device and EASYTRAKCoronary Venous Pace/Sense Lead, GuidantCorporation

• Contak CD/Easytrak Post Approval Study, GuidantCorporation

• Reactive ATP Download Study, Medtronics, Incorp.

• Silent Atrial Fibrillation Detection with StoredEGM’s Study, Guidant Corporation

Alfred Parisi, M.D.

• Azithromycin and Coronary Events Study (ACES),NIH/National Institutes of Health/SERC

Athena Poppas, M.D.

• Percutaneous Left Atrial Appendage TranscatheterOcclusion (PLAATO) Using the X-Caliber System-A,Appriva Medical, Incorporated

• Dobutamine Stress Eschocardiography Core Labora-tory for Noga Viability Study, Biosense, Incorporated

• A Double-Blind Randomized StratifiedPlaceboControlled Parallel Study of Ranolazine SRat Doses of 7, CV Therapeutics

• Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate theEffects of Oral tolvaptan on Left VentricularDilatation and Function in Patients with HeartFailure and Left Ventricular Systolic Dysfunction,Cardiovascular Clinical Studies, L.L.C./Otsuka

• Heart Disease CNS Dsyfunction & Outcome in theElderly, NIH/The Miriam Hospital

Ara Sadaniantz, M.D.

• Multicenter, Randomized Double Blind PlaceboControlled Efficacy Study on the Effects of OralTolvaptan on Left Ventricular Dilatation andFunction in Patients with Heart Failure and LeftVentricular Systolic Dysfunction, CardiovascularClinical Studies/Otsuka

• SPAN-CHF: A Lifespan Demonstration Project inDisease Management, New England Medical Center

• Atrial Fibrillation Follow-up Investigation of RhythmManagement, NIHNational Institutes of Health/SERC

• A Pilot, Open-Label Safety, Tolerance and EfficacyEvaluation of CM-3 in Patients with conjestiveHealth Failure, Milkhaus Labs

• The Effect of LDL-Cholesterol Lowering BeyondCurrently Recommended Minimum Targets onCoronary Heart Disease Recurance in Patients withPre-Existing CHD, ICON

Barry Sharaf, M.D.

• A Double Blind Multicenter Placebo Controlled Studyof Quinapril in Women with Chest Pain, CoronaryFlow Reserve Limitations and Evidence of MyocardialIschemia int he Absence of SignificantEpicardial Coronary, University of Florida-Gainesville

• A Multicenter Randomized Double Blind PlaceboControlled Study to Evaluate the Efficacy and Safetyof Ad5FGF-4 in Patients with Stable Angina, BerlexLaboratories

• Women’s Ischemia Syndrome Evaluation ExtensionAT-1 Receptor Blocker Ancillary Trial AngiographicCore Laboratory, University of Pittsburgh/NIH

• Women’s Ischemia Syndrome Evaluation (WISE),University of Pittsburgh/NHLBI

• A Prospective, Randomized Double Blind Multi-Center Study Comparing the Effects of AtorvastatinVersus Pravastatin on the Progression andQuantification of Coronary Atherosclerotic Lesions asMeasured by Intravascular Ultrasound, CovalentGroup, Incorporated/Warner-Lambert

• A Double Blind Multicenter Placebo Controlled Studyof Quinapril in Women With Chest Pain, University ofFlorida-Gainesville

Satish Sharma, M.D.

• The Effects of Antiarrhythmic Therapy inMaintaining Stability of Sinus Rhythm (SAFE-T), VACooperative Studies Program

• Warfarin and Antiplatelet Therapy Study in Patientswith Congestive Heart Failure (WATCH), VACooperative Studies Program

• Antihypertensive and Lipid Lowering Treatment toPrevent Heart Attack Trial (ALLHAT), VA CooperativeStudies Program

• Valsartan Antihypertensive Longterm Use Evaluation(VALUE), Novartis

• Clopidogrel in Unstable Angina to Prevent RecurrentIschemic Events (CURE), Bristol-Myers Squibb/Sanofi

• Reduction of Endpoints in NIDDM with the ALLAntagonist Losartan (RENAAL), Merck,

Peter Tilkemeier, M.D.

• A Randomized, Two-arm Crossover Study of Safety,Tolerability, and Myocardial Perfusion Imaging ofMRE0470 vs. Adenosine, Parexel/King

David Williams, M.D.

• District OC Registry, Biocompatibles Limited

• Post Approval Study for the NIRTM Stent, SCIMEDLife Systems, Incorporated/Medinol


• Dynamic Registry of Percutaneous CoronaryIntervention, University of Pittsburgh/NHLBI

• A Prospective, Randomized Trial Evaluating theTAXUS Paclitaxel - Eluting Coronary Stent in DeNovo Coronary Lesions and In-Stent Restenosis,Parexel/BSC

• Sound Wave Inhibition of Neointimal Growth,PharmaSonics Incorporated

• LightLab Imaging Wire, LightLab Imaging, LLC

• Prevention of Restenosis With Tranilast and ItsOutcome: A Placebo-Controlled Trial (PRESTO),Smith Kline Beecham Pharmaceuticals

• The Palmax-Schatz MiniCrown Balloon-ExpandableStend on the DynastyTM Over the Wire StentDelivery, Cordis Corporation, A Johnson & JohnsonCompany

• Bypass Angioplasty Revascularization Investigation(BARI FOLLOW-UP), University of Pittsburgh/NHLBI

• Stents and Radiation Therapy 40/20 Trial (START 40/20 Trial), Novartis Pharmaceutical Corporation

• A Multicenter Study of the CrossflexTM LC Balloon-Expandable Stent Mounted on the ValorTM OTWDelivery Systemn, Cordis Corporation

• A Double-Blind, Randomized Comparator StudyComparing the Renal Effects of Visipaque 320(iodixanol) vs. Optiray 320 (ioversol) in ChronicStable Renal Failure Subjects Undergoing CoronaryAngiography (VIA-P4-007), Amersham Corporation

• A Prospective, Randomized, Placebo=ControlledTriple-Masked Trial to Evaluate the Safety andEffectiveness of the Novoste Beta-cath system inNative Cornoary Arteries, Novoste Corporation

• DMR in Regeneration of Endomyocardial ChannelsTrial: The Biosense DMR Phase II Randomized Trial,Biosense, Incorp.

• Beta Energy Restenosis Trial-I (Long Term Folow-up),Novoste Corporation

• A Multicenter, Randomized Double Blind Study of theSirolimus-Coated Bx Velocity Balloon ExpandableStent in the Treatment of Patients with DeNovaCoronary Artery Lesions, Cordis Corporation

• Saphenous Vein Graft Intervention Using Bx-tmVelocity-tm Stent and AngioGuard-tm, CordisCorporation

• Distinct Abrupt Closure or Threatened AbruptClosure Registry, Biocompatibles Limited

• A Multicenter Trial of Localized Radiation Therapy toInhibit Restenosis, Cordis Corporation

• Saphenous Vein Graft Intervention Using AngioGuardfor Reduction of Distal Embolization, CordisCorporation

• Bypass Angioplasty Revascularization Investigation II,University of Pittsburgh/NHLBI

• Registry Study to Assess Ventricular Function and ST-Resolution Post Primary PTCA/Stent Intervention,TherOx Incoporated

• Palmaz-SchatzTM Crown Balloon Expandable Stendwith PowerGripTM (30TM CROWN), Johnson &Johnson Interventional System Company

• A Multicenter Feasibility Study of the Treatment ofPatients With DeNovo or Restenotic Native Corona,Cordis Corporation

• Trap Vascular Filtration System, Microvena Corp.

• A Multicenter Study of 5-Year Follow-up for theCrossFlex LC Balloon-Expandable Stent Mounted onthe OTW Delivery System in Patients with DeNovo orRestenotic Native Artery Lesions, Cordis Corporation

• Randomized Controlled Study of Aqueous OxygenSystem Solution Infusion of 90 Minutes Post PrimaryPTCA/Stent Intervention in Acute MyocardialInfarction Patients, TherOx Incorporated

• Percutaneous Left Atrial Appendage TranscatheterOcclusion (PLAATO) Using the X-C Caliber SystemFeasibility Study, Appriva Medical, Incorporated

• QuickSeal Arterial Closure System Study, SUB-Q

• A Multi-Center Non-Randomized Study of theSirolimus-Eluting Bx Velocity Balloon-ExpandableStent with Direct Stenting in the Treatment of Patientswith DeNovo Native Coronary Artery Lesions, CordisCorporation

• AST SLK-View Side-Access Coronary Stent Non-Randomized Pivotol Study, Advanced StentTechnologies, Inc.

• A Multicenter, Non-Randomized Study of the 4.0mmSirolimus-Eluting Bx Velocity Balloon-ExpandableStent in the Treatment of Patients with DeNovoNative Coronary Artery Lesions, Cordis Corporation

• TAXUS V A Randomized Double Blind Trial to AssessTAXUS Pacletxel-Eluting Coronary Stents, Slow-Release Formulation in the Treatment of High Risk DeNovo Coronary Lesions, Boston Scientific

• An Evaluation of the Multi-Link Rx Vision SVSCoronary Stent System in the Treatment of Patientswith Abrupt or Threatened Abrupt Closure ofDeNovo or Restenotic Lesions in Native CoronaryArteries or Arterial Bypass Graft Conduits, AdvancedCardiovascular Sys, Inc./Guidant

• A Phase 2, Multicenter Double Blind Placebo-Controlled Dose Ranging Study to Evaluate the Safetyand Efficacy of BO-653 in Prevention of Post-Angioplasty Restenosis in Stented Lesions, ChugaiBiopharmaceuticals, Incorporated

C L I N I C A L P H A R M A C O L O G Y

Paul Calabresi, M.D., Professor of Medicine;

Director, Division of Clinical Pharmacology

Overview

The cancer therapeutics program in the Division of

Clinical Pharmacology, Department of Medicine at

Brown University and Rhode Island Hospital is bridging

the gap between the research laboratory and the cancer

patient. During the last two years our group of dedicated

laboratory and clinical scientists have made significant

strides in understanding the cellular basis of cancer,

elucidating biochemical and molecular differences

between normal and neoplastic cells, and improving the

treatment options for patients with cancer.

Our cell biology group has gained insights into the

molecular differences between normal and cancer cells

that govern their responsiveness to anticancer therapy.

For example, we have found that certain breast cancer

cells produce a protein on their surface, designated

GPR-30, that is capable of binding anti-estrogen drugs,

such as tamoxifen, and subsequently inducing tumor

growth. Studies are underway to define and identify

the specific cell-signaling pathway(s) involved in this

process as well as correlate the presence of this protein

with lack of response to therapy. In parallel studies,

our drug discovery group is designing and evaluating

novel agents capable of specifically disabling GPR-30

and potentially improving the efficacy of tamoxifen-

based therapy for breast cancer.

In a different disease model, our cell and molecular

biologists have found that hormone-insensitive

prostate cancer cells also express a protein, Raf kinase

inhibitory protein (RKIP) that appears to be predictive

for the effectiveness of camptothecin-based therapy.

The expression of this protein also correlates with the

sensitivity of colon cancer, mesothelioma and

glioblastoma cells to camptothecin-based

combinations. These studies have been expanded

clinically where our group is participating, along with

several Harvard-affiliated hospitals, in a multi-center

Phase I/II clinical analysis of a novel, orally active,

camptothecin analogue (gimatecan) in the United

States. Results of these studies will be valuable in the

future design of more effective cancer therapies.

Molecular biologists in our Division also are studying

in detail the cell signaling interactions between

competing apoptotic and survival/proliferation

CLINICAL PHARMACOLOGY

pathways. These scientists have found several, previously

unappreciated, co-regulatory interactions between

receptor-mediated cell death processes (ie. Fas) and

cytokine-based proliferative pathways. Since the control

of tumor cell apoptotic is the ultimate goal of therapy, it

is anticipated that continued research to elucidate the

interplay between the competing processes in cancer

cells will lead to novel insights into methods to treat

various forms of human cancer.

Our drug discovery group has identified a new chemo-

therapeutic agent, taurolidine, that is less toxic to

normal cells and tissues but capable of specifically and

rapidly killing cancer cells by inducing mitochondrial-

mediated apoptosis. Clinically, we completed several

clinical trials, in patients with advanced ovarian cancer

and malignant brain tumors, and have obtained

promising results. Information from these early trials is

being used to refine therapy delivery methods for future

use in patients with cancer. At the same time, we are

designing and evaluating novel analogues of taurolidine

with the goal of increasing its cancer cell killing activity


and chemical stability. Of interest, we have also

recently observed that the combination of taurolidine

and gimatecan may hold promise in the treatment of

mesothelioma. A cooperative research and clinical

program, with centers at Rhode Island Hospital,

Columbia University, and Mount Sinai Hospital in

New is being formed to expedite the laboratory and

clinical studies to validate this clinical use. We also are

using this same group of novel chemotherapeutic

drugs to develop a novel method to ‘purge’ tumor cells

from marrow or peripheral blood in cancer patients

by specifically inducing tumor cell apoptosis. This

“purged” material can then be used in marrow

transplant procedures after high dose chemotherapy

to treat advanced cancers.

Funding for this research has been obtained from the

U.S. government, private foundations and the

pharmaceutical industry, including the T.J. Martell

Foundation, the PhRMA Foundation, the American

Cancer Society, the Department of Defense, and

several pharmaceutical companies.

Sadly, Paul Calabresi, MD, MACP, passed away on

October 25, 2003 having lost his life to cancer, the

disease he devoted his life to curing. He was an

internationally recognized oncologist who added

luster and renown to our Department. He will be

sorely missed.

Faculty MembersFULL-TIME FACULTY(Hospital and Foundation Based)

Paul Calabresi, M.D., Professor, Rhode Island Hospital,University Medicine Foundation

Devasis Chatterjee, Ph.D., Assistant Professor(Research), Rhode Island Hospital

James Darnowski, Ph.D., Associate Professor(Research), Rhode Island Hospital

Edward Filardo, Ph.D., Assistant Professor (Research),Rhode Island Hospital

Bai-Chuan Pan, Ph.D., Professor (Research), RhodeIsland Hospital

Ming Chu, Ph.D., Professor Emeritis (Research), RhodeIsland Hospital

ADJUNCT FACULTY

Wolfgang Oster, M.D., Adjunct Professor, Rhode IslandHospital

National andInternational Honorsand Recognitionof Faculty

Paul Calabresi, M.D., MACP• Laurea Honoris Causa (Honorary Degree in Medi-

cine), University of Naples School of Medicine

• Distinguished Alumni Service Award , Association ofYale Alumni in Medicine

• Dedication of The Paul Calabresi Conference Room,Yale Cancer Center

Invited presentations:

• Keynote Speaker, 6th National Meeting of G.O.I.M.,“Dalla Biologia Molecolare all’Accreditamento diEccellenza” Naples, Italy

• Invited Lecture (Lettura Magistrale), Gruppo Italianoper lo Studio e la Terapia del Mesotelioma Maligno(G.I.M.E.), Stresa, Italy

• Scientific presentation, “Antineoplastic effects ofST1481, a novel camptothecin, on human malignantmesothelioma”American Association for CancerResearch (AACR), San Francisco, CA

• Member and Past Chairman (1995), Board ofDirectors, New England Cancer Society

• Member, National Board of Trustees, Leukemia &Lymphoma Society

• Member, Board of Overseers, Tufts University Schoolof Medicine

• Member, Board of Overseers, E. Bronson IngramCenter, Vanderbilt University, Nashville, TN

• Member, Editorial Board, Critical Reviews inOncology/ Hematology

• Guest Editor, Medicine and Health in Rhode Island

• Reviewer and former Member of the Editorial Board,New England Journal of Medicine

• North American Editor, International Journal ofMultidisciplinary Oncology

Devasis Chatterjee, Ph.D.• Member, American Association for Cancer research


• “Campothecins as regulators of the FLIP-side ofapoptosis,” T.J. Martell Foundation ResearchSymposium, October 2001

• “Taurolodine: A novel chemotherapeutic agent whichinduces caspase-dependent apoptosis in multiplemyeloma cells,” New England Cancer Society 115thAnnual Meeting, November 2001.


• “Regulation of apoptotic and survival pathways bytaurolodine in multiple myeloma cells,” AmericanAssociation of Cancer Research 93rd Annual Meeting,April 2002.

• “Regulation of apoptotic and survival pathways byTaurolidine in human multiple myeloma cells”, NewEngland Cancer Society, 116th Meeting, November2002.

• “Stat3, a caspase target during CD95-triggeredapoptosis”, American Association for Cancer Research94th Annual Meeting, July, 2003.

Ming Chu, Ph.D.• Member, Biohazards and Laboratory Safety

Committee, Rhode Island Hospital

James W. Darnowski, Ph.D.• Member, CET-3 Study Section, Department of Defense

Breast Cancer Research Program

Ad hoc reviewer:

• Cancer Research

• Biochemical Pharmacology

• Molecular Pharmacology

• Cancer

• Oncology Research

• Journal of the National Cancer Institute

• Leukemia Research

• Journal of Clinical Oncology

• Canadian National Cancer Institute


• “Therapeutic control of cell survival and aptosis,” T.J.Martell Foundation for Cancer Research, October2001

• “Taurolidine triggers receptor-mediated apoptosis inDU145 human prostate tumor cells,” Annual Meetingof the American Association for Cancer Research,April 2002

• “DU145 human prostate tumor cells undergoapoptosis following exposure to taurolidine,” Annualmeeting of the New England Cancer Society,November 2001

• “STAT proteins are a target of caspase-mediatedcleavage during staurosporin-induced apoptosis inthe DU145 human prostate tumor cell model”,Annual Meeting of the American Association forCancer Research, July 2003

Edward J. Filardo, Ph.D.• Career Development Award, Department of Defense

• Consultant, Proctor and Gamble Pharmaceuticals

Ad hoc reviewer:

• Breast Cancer Research & Treatment

• Cancer Research

• FASEB

• Journal of Steroid Biochemistry & Molecular Biology

• Trends in Endocrinology & Metabolism Endocrinology

• European Journal of Biochemistry


• “GRP30: a novel estrogen receptor with possibleimportance in breast cancer,” T.J. Martell Foundationfor Cancer Research, October 2001.

• “GPR30: a novel estrogen receptor that promotessecond messenger signaling as well as EGF-like effectsin breast carcinoma cells,” Annual meeting of theNew England Cancer Society, Nov. 2001

• “The search for membrane-associated steroidhormone receptors: rapid estrogen signaling via theorphan G-protein-coupled receptor, GPR30,”Divisions of Cardiovascular and Bone MetabolismResearch, Procter and Gamble Pharmaceuticals,February 2002

• “Expression of GPR-30 in human tissues”, Divisionsof Cardiovascular and Bone Metabolism Research,Procter and Gamble Pharmaceuticals, October 2002

• “Regulation of the EGFR by estrogen in breast cancercells”, T.J. Martell Foundation for Cancer Research,October 2002.

• “Engagement of integrin aVb1 is required forestrogen-dependent transactivation of the EGFR inbreast cancer cells”, International Congress onHormonal Steroids and Hormones and Cancer,October 2002.

Linda Nici, M.D.• Writing Committee Member, Guideline for

Pulmonary Rehabilitation Programs, AmericanSociety of Cardiovascular & PulmonaryRehabilitation

• President, Board of Directors, Occupational andEnvironmental Center of RI

• Co-chair, American Thoracic Society on PulmonaryRehabilitation

• Member, Task Force on Women & Girls, Tobacco &Lung Cancer, American College of Chest Physicians

Ad hoc reviewer:

• American Journal of Physiology: Lung Cellular &Molecular Physiology

• American Journal of Respiratory and Critical CareMedicine

• European Respiratory Journal – Cancer AmericanJournal of Pathology

Invited Presenations:

• “The Effect of Pulmonary Rehabilitation on HealthCare Utilization: an International Perspective,”American Thoracic Society, May 2002

• Keynote speaker, “Lung Disease, State of the Nation,”RI Nurses’ Alumni Annual Meeting, April 2002


Bai-Chuan Pan, Ph.D.• Academic Consultant to the Shanghai Institute of

Materia Medica, Academy of Sciences

• Chinese Academy of Science Prizes – First Class

• Chinese National Natural Science Prizes–Second Class

• Chinese National Natural Science Prizes–Third Class

Editorial boards:

• Acta Chimca Sinica (Journal of the ChineseChemical Society)

• Scientia Sinica (Sciences in China)

• Kexue Tongbao (Communication of Sciences)

Research and OtherScholarly Activities

FACULTY MEMBERS OF STUDY SECTIONS ANDADVISORY COMMITTEES

Paul Calabresi, M.D., MACP• Member, Scientific Advisory Board, Carter-Wallace,

Inc.

• Chairman (1998-2001), Scientific AdvisoryCommittee, Columbia University ComprehensiveCancer Center

• Chairman, Scientific Advisory Committee, TJ MartellFoundation

• Chairman, Clinical Pharmacology AdvisoryCommittee, Pharmaceutical Manufacturers’Association Foundation (PhRMA)

• Member, Steering Committee, National Dialogue onCancer, Washington, D.C., Appointed by PresidentGeorge and Mrs. Barbara Bush

• Chairman, External Review Committee for the Univer-sity of Wisconsin, Comprehensive Cancer Center

• Chairman, Director’s Advisory Board, Yale UniversityComprehensive Cancer Center, New Haven, CT

Member, Scientific Advisory Board, Yale UniversityComprehensive Cancer Center, New Haven, CT

• President, Rhode Island Cancer Council, Appointedby Governor Lincoln Almond

• Member, Brown University Oncology Group(BrUOG)

• Chairman of Novel Agents Committee

• Member, Data Safety Monitoring Board

• Member, Lifespan Research Advisory Committee

• Member, Lifespan Cancer Committee

• Chairman, Institutional Review Board, HumanGenome Project, Celera Genomics Corp.

• Member, National Cancer Legislation AdvisoryCommittee Washington, DC — Appointed byPresident George Bush and Senator Diane Feinstein

• President, International Society for GeriatricOncology

• Chairman, Scientific Advisory Board, InstitutoNazionale Tumori, Naples, Italy

• Member, Scientific Advisory Board, Alberta (Canada)Cancer Board

• Member, Diagnostic Advisory Board, Burrill & Co.

• Member, Experimental Therapeutics Program, Dana-Farber/Harvard Cancer Center

TEACHING ACTIVITIES


Paul Calabresi, M.D., MACP• Attending Rounds, Massachusetts General Hospital

• Faculty/Counselor to Brown/Dartmouth advancedtransfer medical students: Wendy Gray, AllisonGoldkamp, Julia Frew and Hannah Famiglietti

• Faculty, Visiting Research Fellows: Roberta Sarmientoand Andrea Sartore-Bianchi

• Faculty & Research Advisor, Paul Martin, M.D., FirstYear Resident, Brown Medical School

Devasis Chatterjee, Ph.D.• Assisted Andrea Bianchi-Sartore, M.D., clinical

research Fellow, with his research on the “Regulationof apoptosis in human colon and mesothelioma cellsby RKIP”

James W. Darnowski, Ph.D.• Faculty Leader, International Medical Fellow Research

Group

2001-2002 Roberta Sariemento

2002-2003 Andrea Bianchi

• Mentor & Research Advisor, Arshad Asnudian, M.D.,Candidate for MS/MD Degree, Brown MedicalSchool

Edward J. Filardo, Ph.D.• Research Mentor, 2001-2003 Jeffrey A. Quinn, MS

Lisa Nici, M.D.• Faculty Leader, Affinity Group Prog. (Biomed 0551)

Co-Facilitator, Workshop on Racial Diversity

Lecturer, University of Rhode Island – PharmDProgram Foundations of Human Disease (PHP/BMS409)

Attending Physician, General Medicine Service, RIHand RISE Clinic The Miriam Hospital


PUBLICATIONS

Paul Calabresi, M.D.• Calabresi, P, Goulette, FA and Darnowski, JW.

Taurolidine: cytotoxic and mechanistic evaluation ofa novel antineoplastic agent. Cancer Res., 61: 6816-6821, 2001.

• Nici, L, Monfils, B and Calabresi, P. Modulation ofBleomycin-induced Pulmonary Toxicity in theHamster by L-Carnitine, J. Appl. Res., 1: 158-166,2001.

• Shrayer, DP, Lukoff, H, King, T and Calabresi, P. Theeffect of taurolidine on adherent and floatingsubpopulations of melanoma cells. Anti-CancerDrugs, 14:295-303, 2003.

• Graeber, CT, Quinn, JA, Kim, D, Steinhoff, MM,Calabresi, P and Filardo, FJ. Estrogen receptor, Eraand GPR30, a heptahelical receptor that promotes theEGF-like effects of estrogen possess different tissueexpression patterns. Manuscript in preparation.

• Graeber, CT, Quinn, JA, Kim, D, Steinhoff, MM,Calabresi, P and Filardo, FJ. Expression of GPR30, aG-protein-coupled receptor that promotes the EGF-like effects of e3strogen, in normal mammaryepithelia and invasive mammary carcinoma.Manuscript in preparation.

Devasis Chatterjee, Ph.D.• Mukhopadhay, A, Bueso-Ramos, C, Chatterjee, D,

Pantazis, P, and Aggarwal, BB. Curcumin downregu-lates cell survival mechanism in human prostatecancer cell lines. Oncogene, 20: 7597-7609, 2001.

• Urasaki, Y, Laco, GS, Pourquier, YP, Takebayashi, K,Kohlhagen, G, Gioffre, C, Chatterjee, D, Pantazis, Pand Pommier, Y. Characterization of a noveltopoisomerase I mutation from a camptothecinresistant prostate cancer cell line. Cancer Res. 61:1964-1969, 2001.

• Chatterjee, D, Schmitz, I, Yeung, K, Krueger, A,Kirchoff, S, Krammer, PH, Peter, ME, Wyche, JH andPantazis, P. Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostatecarcinoma cells correlates with de novo synthesis ofCD95 and CD95 ligand and down-regulation of c-FLIPshort. Cancer Res., 61: 7148-7154, 2001.

• Yeung, KC, Rose, DW, Dhillon, A, Yaros, D,Gustafsson, M, Chatterjee, D, McFerran, B, Wyche, J,Kolch, . and Sedivy, JM. RKIP interacts with NIK andTAK1 and inhibits NF-kB activation. Mol. Cell. Biol.,21:7207-7217, 2001.

• Chatterjee, D Braastad, C, Darnowski, J, Pantazis, P,Wyche, J, Sedivy, JM and Yeung, KC. RKIP inhibitsmultiple cell signaling pathways and inducesapoptosis in tumor cells. Cancer Cell, submitted.

• Chatterjee, D, Goldman, M, Braastad, CD, Darnowski,J, Wyche, JH, Pantazis, P and Goodlick, L. Reductionof 9-nitrocamptothecin triggered apoptosis in DU145human prostate cancer cells by ectopic expression of14-3-3. J. Biol. Chem., submitted.

James Darnowski, Ph.D.• Han, Z, Ribizzi, I, Darnowski, J, Pantazis, P, Wyche,

JH and Calabresi, P. The novel antineoplastic drugTaurolidine induces apoptosis by a mitochondrial-dependent mechanism in the HL60 cell line.Anticancer Res., 22:1959-1964, 2002.

• Ribizzi, I, Darnowski, JW, Goulette, FA, Akhtar, MS,Chatterjee, D and Calabresi, P. Taurolidine: preclinicalevaluation of a novel, highly selective, agent for bonemarrow purging. Bone Marrow Transpl., 29, 313-319,2002.

• Han, Z, Wei, W, Dunaway, S, Darnowski, JW, Calabresi,P, Sedivy, J, Hendrickson, EA, Balan, KV, Pantazis, Pand Wyche, JH. Role of p21 in apoptosis andsenescence of human colon cancer cells treated withcamptothecin. J. Biol. Chem., 277: 17154-17160, 2002.

• Whartenby, KA, Darnowski, JW, Freeman, SM andCalabresi, P. A role for MAP kinase in the antitumoractivity of a nucleoside analogue. Cancer GeneTherap., 9:37-43, 2002.

• Allegrini, G, Goulette, FA, Darnowski, JW andCalabresi, P. Thrombospondin-1 plus irinotecan: anovel antiangiogenic-chemotherapeutic combinationthat inhibits the growth of advanced human colontumor xenografts in mice. Cancer Chemother.Pharmacolog., accepted.

• Darnowski, JW, Goulette, FA, Chatterjee, D, Cousens,LP and Calabresi, P. Mechanistic and antineoplasticevaluation of Taurolidine in the DU145 model ofhuman prostate cancer. Biochem. Pharmacol.,submitted.

• Ribizzi, I, Darnowski, JW, Goulette, FA, Akhtar, MSand Calabresi, P. Synergistic cytotoxicity ofazidothymidine (AZT) plus interferon-alpha2a (IFN)in a human myleodysplastic syndrome cell line.Manuscript in preparation.

• Davol,PA, Goulette,FA, Frackelton,ARJr andDarnowski, JW. Association of p53 protein with DNApolymerase beta: disruption by recombinantinterferon alpha-2a in a cisplatin resistant humanmelanoma cell line. Manuscript in preparation.

• Cousens, LP, Goulette, FA, Calabresi, P and Darnowski,JW. IFNa-stimulated signaling inhibits Fas ligand-induced apoptosis. Manuscript in preparation.

• Goulette, FA, Cousens, LP, Chatterjee, D, Braastad, Cand Darnowski, JW. STAT protein expression is reducedin a caspase-dependent manner during staurosporineinduced apoptosis in the DU145 human prostate tumorcell model. Biochemical Pharmacol., submitted.


Edward Filardo, Ph.D.• Filardo,EJ, Quinn,JA, Frackelton, ARJr and Bland,KI.

Estrogen action via the G-protein-coupled receptor,GPR30: stimulation of adneylyl cyclase and cAMP-mediated attenuation of the epidermal growth factorreceptor-to-MAPK signaling axis. Molec. Endocrinol.,16: 70-84, 2002.

• Filardo, EJ. Epidermal growth factor receptor (EGFR)transactivation by estrogen via the G-protein coupledreceptor, GPR30: a novel signaling pathway withpotential significance for breast cancer. J. SteriodBiochem. Mol. Biol., 80: 231-238, 2002.

• Quinn, JA, Graeber, CT and Filardo, EJ. “Inside-out”integrin activation by the G-protein-coupledreceptor, GPR30, promotes the EGF-like effects ofestrogen. J. Cell Biol., submitted.


Total Basic Research Expenses Academic Year 2002 $1,467,833 $260,232 $1,728,065

Academic Year 2003 $1,014,744 $148,549 $1,163,293


Academic Year 2003 $1,842 $460 $2,302

BASIC RESEARCH

Paul Calabresi, M.D.

• T.J. Martell - Administrative, T.J. Martell Foundation

• Assessment of the Potential Antineoplastic Activity ofTaurolidine, Carter-Wallace Incorporated

• Modulation of Bleomycin Lung Injury by 1-carnitine,Sigma Tau

• Evaluation of Taurolidine Pharmacokenetics, Carter-Wallace, Incorporated

• Assessment of the Antineoplastic Activity of ST1481in Human Malignant Mesothelioma, SigmaPharmaceutical Incorporated

• Analysis of the In Vitro Cytotoxic and In VivoAntineoplastic Activity of ST184, Sigma-TauPharmaceuticals, Incorporated

• Assessment of Taurolidine Activity in In Vitro andMurine Models of Pancreatic Cancer and Melanoma,Carter-Wallace, Incorporated

• Assessment of Taurolidine Activity in In Vitro andMurine Models of Carcinoma of the Lung andMesothelioma, Carter-Wallace, Incorporated

• Assessment of Taurolidine Activity in in Vitro andMurine Models of Carcinoma of the Breast, Carter-Wallace, Incorporated

• Assessment of Taurolidine Activity in in Vitro andMurine Models of Human Ovarian and Brain Cancer,Carter-Wallace, Incorporated

• Assessment of Taurolidine Activity in In Vitro andMurine Models of Prostate Cancer and Colon Cancer,Carter-Wallace, Incorporated

• Assessment of Taurolidine Activity in In Vitro andMurine Models of Leukemias, Lymphomas andMarrow-Sensitivity, Carter-Wallace, Incorporated

• Amifostine Cytotoxicity in a Human MyelodysplasticCell Line, Pharmaceutical Research and Manufacturersof America Foundation, Inc

Devasis Chatterje, Ph.D.

• Regulation of Apoptosis in Human Prostate CancerCells by the Expression of RKIP, Lifespan

James Darnowski, Ph.D.

• Preclinical Studies of Taxotere and IonizingRadiation in an Androgen-Sensitive and Androgen-Insensitive Prostate Cancer, Aventis PharmaceuticalsProducts, Incorporated

• Development of Novel Therapies for HumanProstate Cancer, T.J. Martell Foundation

Edward Filardo, Ph.D.

• Estrogen Signaling Via GPR30, American CancerSociety

• Evaluating of GPR30, a Novel Estrogen Receptor forAssessing Responsiveness to Anti-estrogen Therapy,US Department of Defense-Army

CLINICAL RESEARCH

Paul Calabresi, M.D.

• Evaluation of Serum 1-Carnitine in Cancer Patients:A Descriptive Study, Sigma-Tau Pharmaceuticals,Incorporated, An Open Label Study of the Safetyand Efficacy of Taurolidine 2% SolutionAdministered Intravenously, Carter-WallaceIncorporated

• An Open Label Study of the Safety and Efficacy ofTaurolidine 0.5% Electrolyte Solution AdministeredIntravenously, Carter-Wallace Incorporated

E N D O C R I N O L O G Y

Robert J. Smith,

Professor of

Medicine;

Director,

Division of

Endocrinology

and the Hallett

Center for

Diabetes and

Endocrinology

Overview

The Division of Endocrinology at Brown MedicalSchool is undergoing major expansion with the develop-ment of the new Hallett Center for Diabetes and Endo-crinology, a Bone Density Unit with state-of-the artdiagnostic and osteoporosis management capabilities, anoutpatient Clinical Research Unit, and the new Diabetesand Endocrinology Research Laboratories. The HallettCenter was created in 2001 in response to a recognizedurgent need for a directed program on diabetes mellitus.The Hallett Center represents the first comprehensive,academic diabetes center in the state of Rhode Island.Recognizing the links between diabetes and otherendocrine diseases, the Hallett Center is structured tointegrate programs on diabetes and the full spectrum ofendocrine disorders. The Center has been designed toinclude an outpatient facility providing patients andreferring physicians with access to endocrinologists andmultiple other subspecialists, a patient educationprogram, and inpatient services, which are coordinatedwith the educational, clinical and basic research

activities of the Division of Endocrinology.

ENDOCRINOLOGYFaculty MembersFULL-TIME FACULTY(Hospital and Foundation Based)

Robert J. Smith, M.D., Director, Professor, RhodeIsland Hospital, University Medicine Foundation

Linda Bausserman, Ph.D., Associate Professor, TheMiriam Hospital

Dominic Corrigan, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Geetha Gopalakrishnan, M.D., Assistant Professor,Rhode Island Hospital , University MedicineFoundation

James V. Hennessey, M.D., Associate Professor,Associate Director for Clinical Education, RhodeIsland Hospital, University Medicine Foundation

Marc J. Laufgraben, M.D., Clinical Assistant Professor,Associate Director for Clinical Care, Rhode IslandHospital, University Medicine Foundation

Paul Levinson, M.D., Associate Professor, MemorialHospital of Rhode Island

David B. MacLean, M.D., Adjunct Associate Professor,Rhode Island Hospital, University MedicineFoundation

Lu-Guang Luo, M.D., Assistant Professor, RIH

Eduardo A. Nillni, Ph.D., Associate Professor, RIH

VOLUNTEER FACULTY

Padma Balasubramanian, M.D., Clinical AssistantProfessor, Rhode Island Hospital

Lucinda Barnard, M.D., Clinical Assistant Professor,Memorial Hospital of Rhode Island

Robert Dobrzynski, M.D., Clinical Instructor, TheMiriam Hospital

Charles Eil, M.D., Ph.D., Clinical Associate Professor,Roger Williams Medical Center

Michael Hein, M.D., Clinical Instructor, MemorialHospital of Rhode Island

Charles B. Kahn, M.D., Clinical Professor, The MiriamHospital

Dennis Krauss, M.D., Clinical Assistant Professor, TheMiriam Hospital

Valerie Thomas, M.D., Clinical Assistant Professor, TheMiriam Hospital

ADJUNCT FACULTY

Douglas P. Kiel, M.D., Ph.D., Adjunct AssociateProfessor, Rhode Island Hospital

Joseph Tucci, M.D., Adjunct Professor, Roger WilliamsMedical Center


FACULTY TRANSITIONSNew Faculty

Name Former Position Faculty Rank

Dominic Corrigan, M.D. Chief, Endocrine Division Clinical AssistantAbington Memorial Hospital, Philadelphia Professor of

Medical Director, Abington Memorial Hospital Medicine

and Diabetes Teaching Center, Philadelphia

Robert Dobrzynski, M.D. Fellow, Albany Medical Center Clinical Instructor

Marc Laufgraben, M.D. Private Practice Clinical AssistantProvidence, RI Professor

Geetha Gopalakrishnan, M.D. Fellow, Stanford University Assistant Professor

National andInternational Honorsand Recognition ofFaculty

Linda Bausserman, Ph.D.Invited Presentation:

• “Advances in Prevention through Optimal LipidLowering”, New York, NY

Geetha Gopalakrishnan, M.D.Invited Presentation:

• “Vertical Transmission of HIV”, Indian MedicalAssociation, Chennai, India

James V. Hennessey, M.D.• Listed in Top Doctors in Rhode Island 2002, May

edition of Rhode Island Monthly

• Listed in Guide to Top Doctors

• Recipient of Air National Guard Medicine Man Award

• Program Director, New England Thyroid Club,Annual Meeting


• “Selective Estrogen Receptor Modulation:Applications in the Post Menopausal Woman”, OB-GYN Grand Rounds, Metro West Hospital,Framingham, MA

• “Thyroxine New Drug Applications: Why, How andWhere do we Stand?” New England Thyroid ClubAnnual Meeting, Waltham, MA

• “Internal Medicine Update”: Rhode Island Chapterof the American College of Physicians. ProgramCommittee Chair, Program Chair and Moderator,Newport, RI

• “Selective Estrogen Receptor Modulation:Applications in the Post-Menopausal Woman afterWHI”, Medical Grand Rounds, Saint Raphael’sHospital, New Haven CT

• Program Chair and Moderator, Rhode IslandAmerican College of Physicians Annual Meeting.Warwick, RI, April 2003

• “Thyroid Nodules and Osteoporosis Updates 2003”,Rhode Island Academy of Family Practice AnnualUpdate, Groton, CT

Marc J. Laufgraben, M.D.• Editorial Board, Internal Medicine and Critical Care

Pocketbook

• Co-chair, Rhode Island Chronic Care Collaborative

• Faculty, National Diabetes Education Initiative

• Editorial Board, Tarascon Pocket Pharmacopia


• “Osteoporosis 2001”, Seminar by the Sea, Universityof Rhode Island College of Pharmacy, Newport, RI

• “Why Do Diabetics Develop Foot Problems?”, Post-graduate Course on The Challenge of ManagingDiabetes Mellitus, Brown Medical School,Providence, RI

• “Diabetes and Cardiovascular Disease: The Role ofGlycemic Management”, Medical Grand Rounds,Rhode Island Hospital, Providence, RI

• “Diabetes and Dyslipidemia: New TreatmentGuidelines”, Rhode Island Department of Health,Diabetes Control Program, Providence, RI,

• “Diabetes: Are You At Risk? ”NBC10 Health FitExpo, Providence, RI

• “Update in Diabetes: New Options for GlycemicManagement”, ACP-ASIM Fall Update in InternalMedicine, Newport, RI

• “Calcimimetics in the Management of ParathyroidDisorders”, Endocrine Grand Rounds, Rhode IslandHospital, Providence, RI


• “Combination Therapy for Type 2 Diabetes”, MedicalGrand Rounds Rhode Island Hospital, Providence, RI

• “Update on the Metabolic Syndrome”, Staff GrandRounds South County Hospital, Wakefield, RI

• Plenary Lecture: “Caring for Adults with Diabetes”,Rhode Island Chronic Care Collaborative, CMELearning Session, Warwick, RI

Paul Levinson, M.D.• Listed in Guide to Top Doctors

• Recipient of Service Award from the DiabetesFoundation of Rhode Island

• Member, Publications Committee, AmericanAssociation of Clinical Endocrinology

Lu-Guang Luo, M.D.• Associate Editor, Journal of Alzheimer’s Disease

Presentations:

• “Effects of Thyroid Hormone on Food Intake,Hypothalamic Na/K ATPase Activity and ATPContent”, 2002 The Endocrine Society AnnualMeeting, San Francisco, CA

• “Evidence for Direct Energy Sensing in theHypothalamus (a Hypothalamic Ergostat)”, 2002 TheEndocrine Society Annual Meeting, San Francisco,CA

• “Activation of EGF Receptors in Pancreatic Cells byThyrotropin Releasing Hormone (TRH): Cross-talkBetween Neuropeptide and Growth FactorReceptors”, 2002 Endocrine Society Annual Meeting,San Francisco, CA

David B. MacLean, M.D.• Organized and chaired symposium on “The

Andropause: Impact of Aging in Males” at the 3rdInternational Workshop on Musculoskeletal andNeuronal Interactions (ISMNI), Corfu, Greece

Eduardo A. Nillni, Ph.D.• Recipient of The Bruce Selya Award for Research

Excellence


• “Leptin Stimulates the Expression and Biosynthesis ofProhormone Convertases 1 and 2 (PC1 and PC2) inHypothalamic Neurons”, Taos, NM

• “The Biology of ProThyrotropin Releasing Hormone”Beth Israel-Deaconess Hospital and Harvard MedicalSchool

• “Processing of ProTRH and New BiologicalProducts”, Tufts University Medical School

• “Leptin Action on TRH Neurons” MillenniumPharmaceuticals, Cambridge, Massachusetts

• “Obesity and ProTRH Regulation”, University ofMassachusetts, Amherst

• “The Role of the Thyroid Axis in Energy Balance:ProTRH in Obesity and Thermal Regulation”, OregonHealth & Science University Seminar Series

• “Regulation of the Hypothalamic ProhormoneConvertases 1 and 2 Expression by Fasting andLeptin” University of South Florida

Robert J. Smith, M.D.• Co-Chair, 1st Joint Symposium of the Growth

Hormone Research Society and the InternationalSociety for IGF Research, Boston, MA

• Editorial Board, Journal of Growth Hormone and IGFResearch

• Member, Special Programs Committee, TheEndocrine Society

• Co-organized Brown Medical School CME course on“The Challenge of Managing Diabetes Mellitus: AMultidisciplinary Approach to the Diabetic Foot”


• “Confronting Diabetes as an Epidemic Disease of OurTime”, Rhode Island Hospital Founders’ Day

• “Type 2 Diabetes Mellitus: Linking Pathophysiologyand Therapy”, Landmark Medical Center,Woonsocket, RI

• “You Have Diabetes: What You Can Do and Why YouShould”, Lions Club Sight Awareness Program,Cranston, RI

• “Epidemiology, Pathophysiology, and Therapy ofDiabetes Mellitus” in CME course on “The Challengeof Managing Diabetes Mellitus: A MultidisciplinaryApproach to the Diabetic Foot”, Providence, RI

• Visiting Professor at University of Cincinnati,Department of Pediatric Endocrinology; lectured on“Significance and Molecular Basis of Insulin and IGF-I Specificity Mechanisms”

• “Role of Grb10 in Insulin Action”, 1st InternationalConference on Molecular Basis of MetabolicRegulation, Bari, Italy

• “Insulin and Glucose Management in the DiabeticSurgical Patient”, Rhode Island Hospital SurgicalGrand Rounds

• “Type 2 Diabetes and the Metabolic Syndrome:Diagnosis, Treatment, and Prevention”, InternalMedicine Update, Keynote Speaker


Research and otherScholarly ActivitiesFACULTY MEMBERS OF STUDY SECTIONS ANDADVISORY COMMITTEES

Geetha Gopalakrishnan, M.D.• HIV Prevention Trials Network Perinatal Working

Group, AIDS Clinical Trial Group

James V. Hennessey, M.D.• Advisor, American Thyroid Association

Douglas P. Kiel, M.D., Ph.D.• Data and Safety Monitoring Board, “Testosterone for

prevention of fracture in men with osteoporosis”

• Ad Hoc Reviewer, NIH Study Section, Epidemiology andDisease Control 3

Paul Levinson, M.D.• Appointed to the Collaborative Practice Committee of

the Rhode Island Department of Health and the RhodeIsland Boards of Medicine and Pharmacy

Eduardo A. Nillni, Ph.D.• Member of the Canada Research Chairs Program

College of Reviewers, Canada Institutes of Health.

• Ad Hoc Reviewer, Endocrinology and Reproductive &Nutritional and Metabolic Sciences Study Section(NIH, SSS-T-10)

• Ad Hoc Reviewer, Molecular and Developmental andCellular Neuroscience-1 Study Section, NIH

• Ad Hoc Reviewer, Special Study section, Molecularand Developmental and Cellular Neuroscience

Robert J. Smith, M.D.• Appointed to the Diabetes Professional Advisory

Council of the Rhode Island Department of Health

TEACHING ACTIVITIESEDUCATION HONORS

Geetha Gopalakrishnan, M.D.• Dean’s Teaching Excellence Award from Brown

Medical School

James V. Hennessey, M.D.• Dean’s Teaching Excellence Award from Brown

Medical School

Marc J. Laufgraben, M.D.• Dean’s Teaching Excellence Award from Brown

Medical School


Robert Smith, MD• Program Director, Endocrinology Fellowship

Lectures to Medical Housestaff

Geetha Gopalakrishnan, M.D.James V. Hennessey, M.D.Marc J. Laufgraben, M.D.Robert J. Smith, M.D.

Endocrinology Teaching Attending RoundsGeetha Gopalakrishnan, M.D.James V. Hennessey, M.D.Marc J. Laufgraben, M.D.Robert J. Smith, M.D.

Medical Residency Teaching AttendingJames Hennessey, M.D.

Brown Medical School Pathophysiology CourseJames V. Hennessey, M.D., DirectorGeetha Gopalakrishnan, M.D., ParticipantMarc J. Laufgraben, M.D., ParticipantRobert J. Smith, M.D., Participant

Introduction to MCB Faculty Trainer ResearchEduardo A. Nillni, Ph.D.Robert J. Smith, M.D.

Introduction to Pathobiology Trainer ResearchRobert J. Smith, M.D.

Graduate Thesis AdvisingEduardo A. Nillni, Ph.D.Robert J. Smith, M.D.

Undergraduate Thesis AdvisingRobert J. Smith, M.D.Eduardo A. Nillni, Ph.D.

SELECTED PUBLICATIONSLinda Bausserman, Ph.D.• Kamboh MI, McGarvey ST, Aston CE, Ferrell RE,

Bausserman L. Plasma lipoprotein(a) distribution andits corre-lates among Samoans. Human Biology.72:321-36, 2000.

• DePrince, K.M., McGarvey, S.T., McAllister AE,Bausserman, L., Aston, C.E., Ferrell RE, Kamboh, M.I.Effect of two APOA repeat polymorphisms (kringle 4and pentanucleotide repeats) on plasma Lp(a) levelsin American Samoans, Human Biology. 73:91-104, 2001.

• Mahajan A, Flynn MM, Bausserman LL, DiSpigno MG,Tashima KT. Changes in body habitus and serum lipidabnormalities in HIV- positive women on HAART: a 3.5year follow-up study. J AIDS, 2001, 28:332-335.

• Stoney CM, West S, Hughes MA, Falko JM, LentinoLM, Finney M, Bausserman L. Acute psychologicalstress reduces plasma triglyceride clearance.Psychophysiology. 28:30-35, 2002.

• Tashima KT, Bausserman L, Alt EN, AznarE, FlaniganTP. Lipid changes in patients initiating efavirenz andindinavir based antiretroviral regimens. AIDS ClinTrials. 4:29-36, 2003.


James Hennessey, M.D.• Hennessey JV, Chromiak J, Puhl J, Vandenburgh H,

DellaVentura S, Maclean DB. Growth hormoneadministration and/or exercise effects on muscle fibertype and diameter in the frail elderly. J. AmericanGeriatrics Society. 2001;49:852-858.

• North DL, Shearer, DR, Hennessey JV, Donovan GL.Effective Half-life of 131I in Thyroid Cancer Patients.Health Physics. 2001;81(3):325-329.

• Santoro C, Cosmas A, Forman D, Morghan A, Bairos L,Levesque S, Hennessey JV, Roubenoff R, Manfredi T.Exercise Training Alters Skeletal Muscle MitochondrialMorphometry in Heart Failure Patients. J Cardiovasc.Risk (in Press)

• Hennessey JV. L-Thyroxine a New Drug? Since when?How could that be? Thyroid 2003; 13(3):279-282

Marc Laufgraben, M.D.• Laufgraben, MJ. Managing Diabetic Dyslipidemia.

Medicine and Health/Rhode Island 2003; 86:112-115.

Eduardo Nillni, Ph.D.• Nillni EA, Lee, A, Lagradi G and Lechan R. 2002.

Opiate withdrawal affects the output of proTRH post-translational processing products in the ventrolateralcolumn of the midbrain periaque-ductal gray. J. ofNeurochem. 80, 874-884, 2002

• Nillni EA, Xie W, Mulcahy L, Sanchez VC, and WetselWC. 2002. Deficiencies in prothyrotropin-releasinghormone (proTRH) processing and abnormalities inthermoregulation in Cpefat mice. Biol Chem. 227,48587-48595.

• Cowley MA, Diano S, Tschöp M, Pronchuk N, Stras-burger CJ, Bidlingmaier M, Esterman M, Smith RG,Heiman ML, Garia-Segura LM, Nillni EA, Mendez P,Low MJ, Colmers WF, Cone RD and Horvath TL.2003. Hypothalamic ghrelin acts presynaptically toregulate orexigenic circuits. Neuron 37:649-661

• Münzberg H, Lihong H, Nillni EA. Hollenberg A andBjorbaek C. 2003. The role of STAT3 in regulation ofhypothalamic proopiomelanocortin (POMC) geneexpression by leptin. Endocrinology, 144: 2121-2131.

Robert Smith, M.D.• McCowen KC, Ling PR, Ciccarone A, Mao Y, Chow JC,

Bistrian, BR, Smith RJ. Sustained endotoxemia leads tomarked down-regulation of early steps in the insulinsignaling cascade. Crit Care Med 2001; 29: 839-846.

• Ling PR, Smith RJ, Mueller C, Mao Y, Bistrian BR.Inhibition of interleukin-6-activated janus kinase/signaltransducers and activators of signaling but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats. Crit Care Med 2002; 30: 202-211.

• Smith RJ. Diabetes Mellitus: A 2003 Perspective. Medi-cine and Health/Rhode Island. 2003; 86:92-95.

• Ling PR, Mueller C, Smith RJ, Bistrian, BR. Hyper-glycemia induced by glucose infusion causes hepaticoxidative stress and systemic inflammation, but notSTAT3 or MAP kinase activation in liver in rats.Metabolism 2003; 52:868-874.

• Giovannone B, Lee E, Laviola L, Giorgino, F, ClevelandC, Smith RJ. Two novel proteins that are linked toinsulin-like growth factor (IGF-I) receptors by theGrb10 adapter and modulate IGF-I signaling. J BiolChem 2003; 278: 31564-31573.

ENDOCRINOLOGY FELLOWSHIP PROGRAMDeparting Fellows

Name Medical School Residency Post Graduate PlansBindubal Balan Bangalore Medical College, India Saint Vincent’s Medical Center Private Practice

Mary Crowell Harvard Medical School University of Washington Private PracticeMedical Center

Luis Arce University of Evangelica, El Salvador Staten Island University Hospital Private Practice

Rekha Kumari J J M Medical College Davengere SUNY HSC at Brooklyn Clinical Assistant Professor,Mysore University, India Louisiana State University

Current FellowsName Medical School ResidencyAldona Finkle Medical University, Gdansk, Poland Umass Memorial Health Care,

Worcester, MA

Maeve Durkan The Royal College of Surgeons, Ireland The Hospital at St. Raphael, New Haven, CT

Nitin Trivedi MGM Medical College, Indore, India St. Vincent’s Hospital, WorcesterMedical Center, MA

Post-Doctoral Research FellowsGreg Fox, M.D., Barbara Giovannone, Ph.D., Jorge Goldstein, Ph.D., Katsuhito Mori, M.D., Ph.D., Eleni Patrozou, M.D.

Ph.D. Thesis Graduate StudentsAimee Hebert, Ph.D., Lawrence Mulcahy, Ph.D, William Tsiaras, Ph.D.



Total Basic Research Expenses Academic Year 2002 $827,977 $303, 443 $1,131,420

Academic Year 2003 $611,696 $247,617 $859,313


Academic Year 2003 $99,915 $26,398 $126,313

BASIC RESEARCH

Lu-Guang Luo

• Effects of Novel Compounds on Metabolism of Ratsin Vivo and In Vitro. Pfizer

• Throtropin Releasing Hormone (TRH) in theAlzheimer Hippocampus. Alzheimer’s Association

• Effects of Novel Compounds on Neurons. Pfizer

Eduardo Nillni, M.D.

• ProTRH Gene Transcription and Biosynthesis byLeptin. NIH/Yale

• Regulation of Hypothalamic POMC by Leptin. BethIsrael Deaconess

• The Role of PreproTRH-Derived Peptides inCocaine Action. NIH/Yale

• ProTRH Sorting to the Regulated Secretory Pathway.NIH/NDS

Robert Smith, M.D.

• Role of GRB10 As an Insulin Receptor AdapterProtein. National Institutes of Health

• Nutrition, Cytokines and Anabolic SignalingMechanisms. National Institutes of Health

• Mentor-Based Posdoctoral Fellowship Program.American Diabetes Association

CLINICAL RESEARCH

James Hennessey, M.D.

• A Multicenter, Double Blind Randomized Placebo-Controlled Study to Evaluate the Safety and Efficacyof Zoledronic Acid in the Treatment of Osteoporosisin Postmenopausal Women Taking Calcium andVitamin D. Novartis

• Attenuation of Muscle Wasting with GrowthHormone. NIH

• Randomized Multicenter Parallel Group Study toDetermine if Knowledge of Baseline VertebralFracture Prevalence (As Determined by HologicIVA) and Bone Turnover Marker Levels ImprovePersistence with Actonel 5 mg Daily Therapy inPatients With GIO. Aventis

• A Ramdomized Multicenter Double-Blind, PlaceboControlled Parallel Group, Multi-Dose Study of theSafety and Efficacy of Synthroid in Patients with MildThyroid Failure. Knoll

Marc Laugraben, M.D.

• An Assessment of the Calcimimetic Agent AMG 073for the Treatment of Subjects with ParathyroidCarcinoma or Intractable PrimaryHyperparathyroidism. Amgen

Douglas Kiel, M.D.

• A Multicenter Prospective Study to Assess the Impactof Physician’s Reinforcement on the Subject’sCompliance and Persistance on Treatment usingFeedback on Bone Markers in PreviouslyUndiagnosed Post Menopausal Osteoporotic WomenTreated with Risedronate. Hoescht

• Double Blind Placebo Controlled Dose Ranging Trialto Evaluate the Efficacy of Atorvast. Pfizer

• Teriparatide Compared with Alendronate on SpineBone Mineral Density in Postmenopausal Womenwith Osteoporosis. Eli Lilly and Company

• An 18 month Double-Blind Placebo ControlledPhase III Trial with a 12 month Interim Analysis ofthe Effect of Recombinant Human ParathyroidHormone (ALX1-11) On Fracture Incidence inWomen with Postmenopausal Osteoporosis. NPS/Allelix/Quintiles

• An 18month Open Label Extension Study of theSafety and Efficacy of Recombinant HumanPaarathyroid Hormone, rhPTH (1-84), ALX1-11 inwomen with Postmenopausal Osteoporosis whoParticipated in Protocal ALX1-11-93001. NPS/Allelix/Quintiles

• A Randomized Double-Blind, Multicenter Study toCompare the Safety and Efficacy of AlendronateSodium, 10mg Daily, 35 mg Twice Weekly and 70mgOnce Weekly for the Treatment of Ostroporosis inPost Menopausal Women. Merck

• Phase II Double Blind Placebo-Controlled Trial ofthe Safety Toleration and Efficacy of CP-336,156 andRaloxifene 60mg/d for the Prevention of Bone Loss inPostmenopausal Women. Pfizer

G A S T R O E N T E R O L O G Y

Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg – Artemis and Martha Joukowsky Professor in

Gastroenterology and Professor of Medical Science; Director, Division of Gastroenterology and Liver

Research Center

Overview

The Division of Gastroenterology at Brown Uni-versity extends to Rhode Island, Miriam and Veteran’sAdministration Hospital(s), and is an establishedpresence on the Consultative Service at Women andInfants Hospital. The major missions of the Divisionare to provide state-of-the-art treatment in those withgastrointestinal and liver diseases to educate under-graduates, medical students/residents, postdoctoralfellow in the pathophysiology of digestive diseases, andto engage in “cutting-edge” basic and applied research.The recently completed Endoscopy Suite is equippedwith the latest technological advances, and accom-modates consultations from Southeastern Massachu-setts, Cape Cod, Connecticut and Rhode Island. Thenew Liver Research Center, and Swallowing/MotilityResearch Center are located on the Rhode Island Hos-pital campus, and staffed with twelve principal investi-gators, twenty-five post-graduate physician/scientistsand twenty undergraduate/graduate students, providinga strong basic science program to advance the under-standing of disease processes at the cellular and

GASTROENTEROLOGY

molecular level. N.I.H. sponsored projects include:motility and signal transduction of the G.I. tract, H.pylori in gastric cancer, pathogenesis of NASH, molecu-lar mechanisms of hepatic fibrosis, antiviral approachesto hepatitis B and C infection, molecular pathogenesisof human hepatocellular carcinoma, and monoclonalantibodies in the treatment of G.I. malignancy.

RESEARCH

Faculty in the Division of Gastroenterology hold variedN.I.H., N.S.F., corporate, foundation, and pharmaceuticalgrants to support basic and translational researchactivities. Fifty faculty publications appeared in highlyrespected, peer-review journals in the past year.

TEACHING

The Brown University Fellowship Program in Gasro-enterology is a three-year A.C.G.M.E./A.B.I.M.-accreditedprogram conducted by thirteen fulltime and twenty-sevenvolunteer faculty stationed at the Rhode Island, Miriam,and Veteran’s Administration Hospital(s). Individuals areencouraged to select the Clinical-Scholar, Physician-Scientist, or Research Track; mentors in varied interestsare on-site to assist Fellows allowing a unique clinical/research perspective.



Jack R. Wands, M.D., Jeffrey and KimberlyGreenberg – Artemis and Martha JoukowskyProfessor in Gastroenterology and Professor ofMedical Science; Director, Division ofGastroenterology and Liver Research Center; R.I.Hospital/Miriam Hospital, University MedicineFoundation

Gyorgy Baffy, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Jose Behar, M.D., Professor, Rhode Island Hospital,University Medicine Foundation

Piero Biancani, Ph.D., Professor, Rhode Island Hosp.

Weibao Cao, Ph.D., Assistant Professor, R.I. Hospital

Suzanne de la Monte, M.D., MPH, AssociateProfessor of Pathology and Medicine, R.I.Hospital

Ramy Eid, M.D., Assistant Professor, Veteran’s Admin-istration Medical Center, Univ. MedicineFoundation

Pierre Gholam, M.D., Assistant Prof., Veteran’sAdministration Medical Center, Univ. MedicineFoundation

Fadlallah Habr, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Karen M. Harnett, Ph.D., Assistant Professor, RhodeIsland Hospital

Miran Kim, Ph.D., Assistant Professor of Medicine,The Liver Research Center

Ji-su Li, M.D., Ph.D., Assistant Professor, The LiverResearch Center

Zixu Mao, M.D., Ph.D., Assistant Professor, TheLiver Research Center

Steven Moss, M.D., Associate Professor, RhodeIsland Hospital, University Medicine Foundation

Kittichai Promrat, M.D., Assistant Professor, VAMedical Center, University Medicine Foundation

Harlan Rich, M.D., Associate Professor, RhodeIsland Hospital, University Medicine Foundation

Walter R. Thayer, M.D., Professor, Rhode IslandHospital, University Medicine Foundation

Shuping Tong, M.D., Ph.D., Assistant Professor, TheLiver Research Center

VOLUNTEER FACULTY

Paul Akerman, M.D., Clinical Assistant Professor,Rhode Island Hospital

Nicholas Califano, M.D., Clinical Associate Professor,Rhode Island Hospital

Thomas DeNucci, M.D., Clinical Assistant Professor,Rhode Island Hospital

Christy L. Dibble, D.O., Clinical Assistant Professor,Women & Infants Hospital

Joseph DiMase, M.D., M.S., Clinical Assistant ProfessorEmeritus, Rhode Island Hospital

Edward Feller, M.D., Clinical Professor, Miriam Hospital

Neil Greenspan, M.D., Clinical Assistant Professor,Memorial Hospital of Rhode Island

Edward Iannuccilli, M.D., Clinical Professor, RhodeIsland Hospital

Donald Kaufman, M.D., Clinical Assistant Professor,Memorial Hospital of Rhode Island

Sheldon Lidofsky, M.D., Clinical Assistant Professor,Rhode Island Hospital

James Manis, M.D., Clinical Associate ProfessorEmeritus, VA Medical Center

Peter Margolis, M.D., Clinical Assistant Professor,Rhode Island Hospital

Michael Nissensohn, M.D., Clinical Instructor, MiriamHospital

Theodore C. Palumbo, M.D., Clinical Instructor, RhodeIsland Hospital

Daniel Quirk, M.D., M.P.H., Clinical AssistantProfessor, Rhode Island Hospital

Herbert Rakatansky, M.D., Clinical Professor, MiriamHospital

Steven Sepe, M.D., Ph.D., Clinical Associate Professor,Rhode Island Hospital

Thomas Sepe, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Samir A. Shah, M.D., Clinical Assistant Professor,Miriam Hospital

Jay Sorgman, M.D., Clinical Assistant Professor, MiriamHospital

Joel S. Spellun, M.D., Clinical Assistant Professor,Rhode Island Hospital

Philip Torgan, M.D., Clinical Associate ProfessorEmeritus, Miriam Hospital

Sonia Uchman, M.D., Clinical Associate Professor,Memorial Hospital of Rhode Island

Paul Van Zuiden, M.D., Clinical Assistant Professor,Rhode Island Hospital

ADJUNCT FACULTY

Amer B. Malik, M.D., Adjunct Assistant Professor,Veterans’ Administration Medical Center



György Baffy, M.D., Ph.D.Presentations:

• Annual Meeting of Hungarian Medical Associationof America, Sarasota, FL

• Non-alcoholic steatohepatitis and insulin resistance(Plenary Presentation)

• Annual Meeting of American Association for Studyof Liver Disease, Boston, MA

• UCP2 affects fasting-induced steatosis andmetabolic parameters in lean and obese mice –poster presentation

• American Gastroenterological Association, Orlando,FL 2003

• Liver regeneration is delayed after partialhepatectomy in mice deficient for uncouplingprotein-2 – poster presentation

• Uncoupling protein-2 modulates crypt cellapoptosis rate in the colon of mice fed with high-fatdiet – poster presentation

• Fas-mediated liver injury in ob/ob mice isattenuated in the absence of uncoupling protein-2 –poster presentation

Jose Behar, M.D.• Chairman, Biliary and Pancreatic Section, Rome 3

(International Committee on FunctionalGastrointestinal Diseases) – 2002

Reviewer:

• American Journal Physiology

• Gastroenterology

Presentations:

• American Gastroenterological Association, SanFrancisco, California - 2002

Role of Caveolae in the pathogenesis ofcholesterol induced gallbladder musclehypomotility – Forum presentation

Role of PGF2a in the genesis of phasic

contractions of guinea pig colon – Posterpresentation

Effect of progesterone on the phasic contractionsof the colonic circular muscle of guinea pigs –Poster presentation

• American Gastroenterological Association, Orlando,Florida - 2003

Role of PGE2 in maintenance of toniccontraction of guinea pig gallbladder – PosterPresentation

Smooth muscle abnormalities in female patientswith chronic constipation due to colonic inertia –Poster presentation

Piero Biancani, Ph.D.Reviewer:

• Gastroenterology

• Amer J Physiol.

• J. Pharmacol & Exp. Therapeutics

Presentations:

• American Gastroenterological Association, SanFrancisco, California - 2002

Platelet activating factor contributes to decreasedcat LES tone in acute experimental esophagitis –poster presentation

Hydrogen peroxide reduces LES tone in humanesophagitis – Poster presentation

Platelet activating factor and prostaglandin E2impair Ach release in the body of the esophagusin experimental esophagitis – Poster presentation

Production of proinflammatory cytokines Il-1,IL-6 and IL-8 in active esophagitis – posterpresentation

• American Gastroenterological Association –Orlando, FL 2003

In vitro model of acute esophagitis in the cat -poster presentation

Kinase and cat lower esophageal sphincter tone-poster presentation

Integrin linked kinase in Ach-inducedcontraction of cat esophageal circular smoothmuscle – poster presentation

Pancreatic phospholipase A2 in the loweresophageal sphincter – poster presentation


• Invited speaker – Ca2 dependent/independentcontraction of esophageal smooth muscle. 4th

International Symosium Supra-Esophagealcomplication of reflux, San Diego, CA

• Invited speaker – LES sphincter tone, normal LES,and esophagitis, University of Pisa, Italy andUniversity of Genova, Italy

Weibiao Cao, M.D.Reviewer:

• Inflammatory Bowel Diseases, Inflammatory BowelDisease Grants


Presentations:

• American Gastroenterological Association, SanFrancisco, California 2002

• Neurokinin A signal transduction pathway in humanulcerative colitis – Oral presentation

• Ulcerative colitis affects intracellular Ca2+ signaling inhuman colon – Oral presentation

• Platelet activating factor contributes to decreased catLES tone in acute experimental esophagitis – Posterpresentation

• Hydrogen peroxide reduces LES tone in humanesophagitis – Poster presentation

• Platelet activating factor and prostaglandin E2 impairAch release in the body of the esophagus inexperimental esophagitis – Poster presentation

• American Gastroenterological Association, Orlando,Florida 2003

• Interleukin-1b (IL-1b) induced H2O

2 production

contributes to the motor dysfunction in humanulcerative colitis (UC). –Poster presentation(Distinguished abstract)

• Rho kinase and cat lower esophageal sphincter (LES)tone. –Poster presentation (Distinguished abstract)

• Integrin linked kinase (ILK) in ACh-inducedcontraction of cat esophageal circular smooth muscle(ESO). –Poster presentation

• Pancreatic (Group I B) phospholipase A2 (PLA2) inthe lower esophageal sphincter (LES) –Posterpresentation

• In vitro model of acute esophagitis in the cat. –Posterpresentation

Suzanne de la Monte, M.D., M.P.H.• Panacea Symposium on Oxidative Stress-Mediated

Neurodegeneration, Rockville, M.D.: 2002

• Hypoxia-Induced Alzheimer-type molecular andcellular neurodegeneration


• Massachusetts Institute of Technology, Cambridge,MA: 2002

• Potential Mechanisms of Neuronal Thread Protein-Mediated Neurodegeneration-Relevance toAlzheimer’s Disease

• Sy-Clone, Inc., San Francisco, CA: :2002

Mechanisms of Thymosin-alpha-Inhibition ofGlioblastoma

• Providence College, Providence, RI:: 2002

Potential Neuroprotective Strategies for Preventingof Alzheimer’s Disease

• Manhattan Alzheimer’s Conf., New York, NY: 2003

Role of Neuronal Thread Protein in the Patho-genesis of Alzheimer’s Disease-New Findings

Reviewer:

• Hepatology; Neuroscience

Karen Harnett, Ph.D.• Guest Lecturer, Boston University School of Medicine

Presentations:

• American Gastroenterological Association, SanFrancisco, California 2002

• Platelet activating factor contributes to decreased catLES tone in acute experimental esophagitis – PosterPresentation

• Hydrogen peroxide reduces LES tone in humanesophagitis – Poster presentation

• Platelet activating factor and prostaglandin E2 impairAch release in the body of the esophagus inexperimental esophagitis – Poster presentation

Miran Kim, Ph.DPresentations:

• Ecto-ATPase Meeting, Woodshole, MA

• A P2X7 receptor complex.

• The P2X7-Hsp90 relationship: a matter of tyrosinephosphorylation?

Ji-Su Li, M.D., Ph.D.Presentations:

• Further characterization of glycine decarboxylase(p120), a pre-S envelope –interacting protein in duckhepatitis B virus life cycle. Annual Molecular Biologyof Hepatitis B Virus Meeting, Amherst, MA - 2001

• p120/glycine decarboxylase is a key component forestablishing duck hepatitis B virus infection inprimary duck hepatocytes. Annual Molecular Biologypf Hepatitis B Virus Meeting (2002), Pacific Grove,California

Steven Moss, M.D.• American Gastroenterology Association, Funderburg

award for gastric cancer research, 2002 “Regulation ofgastric epithelial p27kip1 by H. pylori


• Mechanisms of injury: The effects of H. pylori on cellcycle control. H. pylori: Basic Mechanisms to ClinicalCure, 2002. Maui, HI, Nov 2002

• H. pylori and gastric cancer. Gastroenterology GrandRounds: Northwestern University, Chicago, IL;NEMC, Boston, MA & Surgery Grand Rounds, RhodeIsland Hospital

• American Gastroenterology Association annualmeeting, Orlando, May 2003

Oral Presentations:

• Kuzushita N, Aswad B, Park M-J, Moss SF. Deficiencyof p27 leads to increased gastric epithelial andinflammatory responses to Helicobacter pylori.


• Eguchi H, Moss SF. Degradation of p27kip1 byHelicobacter pylori in gastric epithelial cells isproteasome-dependent but independent ofubiquitination or mitogen-activated protein kinase(MAPK) phosphorylation.

• Shirin H, Kravtsov V, Shahmurov M, Bruck R, MossSF, Avni Y, Avinoach I. p27kip1 expression is inverselyrelated to the grade of gastric malt lymphoma,irrespective of disease stage.

• Shirin H, Shevah O, Levine A, Moss SF, Niv Y, BruckR, Avni Y. Effect of high dose citric acid on protonpump inhibitor (PPI) induced false negative 13C-urea breath tests: comparison between omeprazole,pantoprazole and lansoprazole. Gastroenterology2003 (in press).

• Davis GC, Kethu SR, Ramzan UC, Moss SF. Are weperforming unnecessary endoscopies for suspectedupper gastrointestinal bleeding in hospitalizedpatients? Poster presentation

Reviewer:

• Alimentary Pharmacology & Therapeutics, Am JGastro, Cancer, Cancer Res, Digestion, EmergingInfectious Diseases, Gastroenterology, Gut,International Journal of Cancer, Journal of InfectiousDiseases, Journal of Clinical Gastroenterology, JPediatrics, Lancet

Promrat, Kittichai M.D.• American Association for the Study of Liver

Diseases, Boston, MA – 2002

The association of interferon regulatory factor-1promoter polymorphism with HCV infection andinterferon treatment response – Poster presentation

Associations of Chemokine SystemPolymorphisms with Disease Manifestations andTreatment Responses of Chronic Hepatitis C –Poster Presentation

• American Gastroenterological Association –Orlando, FL 2003

One year of pioglitazone therapy is associatedwith histologic improvement in NASH – PosterPresentation

Harlan Rich, M.D.Reviewer:

• Journal of Clinical Gastroenterology

• Member, Internal Medicine Residency CurriculumCommittee, Rhode Island Hospital

• Member, Ambulatory Physician LeadershipCommittee, Rhode Island Hospital

Brown Medical School

• Master of Arts, ad eundem, Brown Medical School(awarded May 2003)

• Speaker: Perspectives on MD2000 MD2000 Retreat,

Brown Medical School, April 2003

• Speaker: Advances in Gastroenterology: Where willthe new technology take us? Brown UniversityDepartment of Medicine Update in InternalMedicine, Providence, RI, May 2003

Shuping Tong, M.D., Ph.D.Invited Presentation:

• Evidence for the involvement of furin, a basicendopeptidase, in the DHBV life cycle. AnnualMolecular Biology of Hepatitis B Virus Meeting,Amherst, Massachusetts

Panelist – 2003

• Workshop 3 (hepatitis B virus e antigen). AnnualMolecular Biology of Hepatitis B Virus Meeting,Pacific Grove, California

Reviewer:

• Hepatology, Gastroenterology, Journal of GeneralVirology

Jack Wands, M.D.• Jeffrey and Kimberly Greenberg-Artemis and

Martha Joukowsky Professor in Gastroenterology,and Professor of Medical Sciences, Brown MedicalSchool

• Bristol-Myers Squibb Research Award in InfectiousDiseases, Brown Medical School

• Master of Arts, ad eundem, Brown Medical School

• Science and Technology Council – 2003

State of Rhode Island and ProvidencePlantations, Governor Donald L. Carcieri

Editorial Boards:

• Hepatology• International Hepatology Communications• Journal of Viral Hepatitis• Viral Hepatitis Reviews• International Journal of Oncology• Cancer Therapy

Editorial Consultant:

• Journal of Clinical Investigation• New England Journal of Medicine• Journal of Biological Chemistry• Proceedings of the National Academy of Sciences• Journal of Infectious Diseases• Gastroenterology• Journal of Virology• Virology• Nature Medicine• Journal of Medical Virology• Journal of Hepatology


• Hepatocellular carcinoma and HBV, MolecularBiology of Hepatitis B Viruses, Amherst, MA


• Alcohol and HIV, N.I.H. Special Emphasis Committee,Bethesda, Maryland

• Hepatic Oncogenesis, International Meeting on Therapyin Liver Diseases, Barcelona, Spain (Panel Discussion)

• Organizer, Session 2: Induction of HepatocellularCarcinogenesis, Falk Workshop: Malignant LiverTumors: Basic Concepts and Clinical Management,Leipzig, Germany

• Human Hepatocellular Carcinoma, Fukuoka CancerSymposium, Fukuoka, Japan

• International Workshop on Molecular Pathogenesis ofHuman HCC ,Sep 17 – 18, 2003 N.I.H., Bethesda,M.D.

• Korean Association for the Study of Liver Disease,Nov 19 – 22, 2003 Seoul, Korea

• Symposium on Receptors and Entry for OncogenicViruses Jul 09 – 12, 2003 Park City, UT

• Chair, Diagnosis of Liver Diseases Oct 16 – 19, 2003Falk Symposium, Freiburg, Germany

Research and OtherScholarly ActivitiesFACULTY MEMBERS OF STUDY SECTIONS ANDADVISORY COMMITTEES

Piero Biancani, Ph.D• Veterans Health Administration – Medical Research

Service, 2003

• Merit Review Sub-committee of Gastroenterology,2003

Suzanne de la Monte, M.D., MPH• Member: NCI-NIH Cancer Research Fellowship (F09)

Study Section

Steven Moss, M.D.• Ad Hoc Reviewer, NIH site visit and reporter to parent

committee. NCI (Cancer Epidemiology, Preventionand Control), May-July 2002

Jack Wands, M.D.National Institutes of Health:

• Chair–Special Emphasis Panel, N.C.I. Study Section,2002

• Chair–Special Emphasis Panel, N.I.A.I.D. Review ofHCV Centers, 2003

• Chair–N.I.A.I.D. Study Section on HCV and HIV, 2002

• Member, Special Emphasis Panel to review NIH GCRLGrant

• Chair, NIDDK Special Emphasis RFA HCV proposals,2003

TEACHING ACTIVITIES

EDUCATION HONORS

Harlan Rich, M.D.• Chairman’s Award for Excellence in Teaching, Brown

Medical School

• Faculty Marshall, 28th Medical Convocation, M.D.Class of 2002, Brown Medical School


Suzanne de la Monte, M.D., M.P.H.• Course Leader: Brown University Graduate Program

in Pathobiology Bio 283: Aging and Disease

Edward Feller, M.D.• Independent Study 15

Harlan Rich, M.D.• Integrated Medical Sciences, Biomed 282

Gastroenterology

Jack Wands, M.D.• Program Director, Gastroenterology Fellowship

• BioMed 305A – Elective in Gastroenterology


Gyorgy Baffy, M.D.• Zhang CY, Baffy G, Perret P et al. Uncoupling

protein-2 negatively regulates insulin secretion andis a major link between obesity, beta cell dysfunction,and type 2 diabetes. Cell 2001;105;745-55.

• Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesityrelated fatty liver is unchanged in mice deficient formitochondrial uncoupling protein 2. Hepatology2002;35:753-61.

Jose Behar, M.D.• Cao W, Harnett KM, Behar J, Biancani P: PGF-

induced contraction of cat esophageal and loweresophageal sphincter circular smooth muscle. Am JPhysiol 2002;283:G282-91.

• Xiao ZL, Rho AK, Biancani P, Behar J. Effects of bileacids on the muscle functions of guinea piggallbladder. Am J Physiol 2002;283:G87-94.

• Xiao ZL, Andrada MJP, Biancani P, Behar J. Reactiveoxygen species: effects on the gallbladder muscle ofguinea pigs. Am J Physiol 2002;282:G300-6.

• Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C,Wang LA, Harnett KM, Behar J, Biancani P. Myosinlight chain kinase and PKC dependent contractionof LES and esophageal smooth muscle. Am J Physiol2001;281:G467-78

• Cao W, Sohn UD, Bitar KN, Behar J, Biancani P,Harnett KM. Mitogen activated protein kinasemediates protein kinase c-dependent contraction of


cat esophageal and lower esophageal sphinctercircular smooth muscle. Am J Physiol GastrointestinLiver Physiol 2003;285:G86-95.

Piero Biancani, Ph.D• Cao WB, Harnett KM, Behar J, Biancani P. Group I

secreted PLA 2 in the maintenance of human LEStone. Gastroenterology 2000;119:1243-52.

• Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, HarnetKM, Behar J, Biancani P. Ca++ induced contractionof cat esophageal circular smooth muscle cells. Am JPhysiol 2001; 280:C980-92.

• Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C,Wang LA, Harnett KM, Behar J, Biancani P. Myosinlight chain kinase and PKC dependent contraction ofLES and esophageal smooth muscle. Am J Physiol2001; 281:G467-78

• Cao W, Harnett KM, Behar J, Biancani P: PGF-induced contraction of cat esophageal and loweresophageal sphincter circular smooth muscle. Am JPhysiol 2002; 283:G282-91.

• Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Har-nett KM. Mitogen activated protein kinase mediatesprotein kinase c-dependent contraction of catesophageal and lower esophageal sphincter circularsmooth muscle. Am J Physiol 2003;285:G86-95

Weibiao Cao, Ph.D• Cao W, Sohn UD, Bitar KN, Behar J, Biancani P,

Harnett KM. Mitogen activated protein kinasemediates protein kinase c-dependent contraction ofcat esophageal and lower esophageal sphinctercircular smooth muscle. Am J Physiol GastrointestinLiver Physiol 2003;285:G86-95

• Cao W, Harnett KM, Behar J, Biancani P: PGF-induced contraction of cat esophageal and loweresophageal sphincter circular smooth muscle. Am JPhysiol 2002;283:G282-91.

• Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormalmotility in ulcerative colitis: role of inflammatorycytokines. Arch Surg 2002;137:439-46.

• Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C,Wang LA, Harnett KM, Behar J, Biancani P. Myosinlight chain kinase and PKC dependent contraction ofLES and esophageal smooth muscle. Am J Physiol2001;281:G467-78

• Cao W, Chen Q, Sohn UD, Kim N, Kirber MT, HarnetKM, Behar J, Biancani P. Ca++ induced contractionof cat esophageal circular smooth muscle cells. Am JPhysiol 2001;280:C980-92.

Suzanne de la Monte, M.D., Ph.D• de la Monte SM, Neely TR, Cannon J, Wands JR.

Ethanol impairs insulin-stimulated mitochondrialfunction in cerebellar granule neurons. Cell Mol LifeSci 2001;58:1950-60.

• de la Monte SM, Wands JR. The AD7c-ntp neuronalthread protein biomarker for detecting Alzheimer’sdisease. Front Biosci. 2002;7:989-96.

• de la Monte SM, Wands JR. Chronic gestationalexposure to ethanol impairs insulin-stimulatedsurvival and mitochondrial function in cerebellarneurons. Cell Mol Life Sci 2002;59:882-93.

• de la Monte SM, Lahousse SA, Carter J, Wands JR.ATP luminescence-based motility-invasion assay.Biotechniques 2002;33:98-104.

FACULTY TRANSITIONSDeparting Faculty

Name Former Position

Michael Kirber, Ph.D. Assistant Professor (Research)

New Faculty


Alyn Adrain, M.D. Appoint: Crouse Hospital, St. Joseph’s Hospital, Clinical Assistant ProfessorUniversity Hospital, Community General Hospital

György Baffy, M.D., Ph.D. Fellow, Harvard Medical School Assistant Professor,Brigham & Women’s Hospital

Weibiao Cao, M.D. Research Associate, Brown Medical School Assistant Professor (Research)

Leslie Cashel, M.D. Appoint: Rhode Island Group Health Associates Clinical Instructor

Ramy Eid, M.D. Fellow in Gastroenterology, Brown Medical School Assistant Professor, Medicine

Pierre Gholam, M.D. Fellow in Gastroenterology, Mt. Sinai, NY Assistant Professor, Medicine

Fadlallah Habr, M.D. Fellow in Therapeutic Endoscopy, Toronto Assistant Professor, Medicine

Miran Kim, Ph.D Postdoctoral Research Fellow, University of Sheffield, U.K. Assistant Professor, Medicine

Kittichai Promrat, M.D. Research Fellow, N.I.H. Assistant Professor, Medicine


• de la Monte SM, Chiche J, von dem Bussche A,Sanyal S, Lahousse SA, Janssens SP, Block KD. Nitricoxide synthase-3 over expression causes apoptosisand impairs neuronal mitochondrial function:relevance to Alzheimer’s type neurodegeneration.Lab Invest 2003;83:287-98.

Ramy Eid, M.D.• Eid R, Moss SF. Helicobacter pylori infection and the

development of gastric cancer. N Engl J Med 2002;346: 66.

Pierre Gholam, M.D.• Gholam PM, Reka S, Charney D et al. Associations

among TNF-alpha polymorphisms, insulin resis-tance and liver disease in morbidly obese subjects.Hepatology 2001;34:A439.

• Gholam PM, Charney DA, Siddiqui RK. The meta-bolic syndrome is associated with steatosis andfibrosis in patients with chronic hepatitis C infec-tion. Gastroenterology 2001;120:2811.

• Gholam PM, Kotler DP, Glancbaum LJ. Liverpathology in morbidly obese patients undergoingRoux-en-Y gastric bypass surgery. Obes Surg2002;12:49-51.

• Gholam PM, Kotler DP. Guidelines for enteral andparenteral nutrition in AIDS wasting syndrome. JParenteral Enteral Nutr 2002;26:1SA-138SA.

Fadlallah Habr, M.D.• Bourjeily G, Habr F, Supinski G. Review of

tracheostomy usage: type and indication. Clin PulmMed 2002;9:267-72.

• Bourjeily G, Habr F, Supinsky G. Review of tracheos-tomy usage: complications and decannulation proce-dures. Clin Pulm Med 2002:273-8.

Karen Harnett, Ph.D• Cao W, Sohn UD, Bitar KN, Behar J, Biancani P,

Harnett KM. Mitogen activated protein kinasemediates protein kinase c-dependent contraction ofcat esophageal and lower esophageal sphinctercircular smooth muscle. Am J Physiol GastrointestinLiver Physiol 2003;285:G86-95

• Cao W, Harnett KM, Behar J, Biancani P: PGF-induced contraction of cat esophageal and loweresophageal sphincter circular smooth muscle. Am JPhysiol 2002;283:G282-91.

• Sohn UD, Cao W, Tang DC, Stull JT, Haeberle C,Wang LA, Harnett KM, Behar J, Biancani P. Myosinlight chain kinase and PKC dependent contraction ofLES and esophageal smooth muscle. Am J Physiol2001;281:G467-78

• Cao W, Chen Q, Sohn UD, Kim N, Kirber MT,Harnett KM, Behar J, Biancani P. Ca++ inducedcontraction of cat esophageal circular smooth musclecells. Am J Physiol 2001;280:C980-92.

Miran Kim, Ph.D• Kim M, Spelta V, Sim J, North RA, Surprenant A.

Differential assembly of rat purinergic P2X7 receptorin immune cells of the brain and periphery. J BiolChem 2001;276:23262-7.

• Kim M, Jiang LH, Wilson HL, North RA, SurprenantA. Proteomic and functional evidence for a P2Xyreceptor signaling complex. EMBO J 2001;20;6345:58.

• Bo X, Jiang LH, Wilson HL, Burnstock G, SurprenantA, North RA. Pharmacological and biophysicalproperties of the human P2X5 receptor. MolPharmacol 2003;63:1407-16.

• Bo X, Kim M, Nori SL, Shoepfer R, Burnstock G,North RA. Tissue distribution of P2X4 receptorsstudied with an ectodomain antibody. Cell Tissue Res(in press).

Ji-Su Li, M.D., Ph.D• Spangenberg HC, Lee HB, Li J, Tan F, Skidgel R,

Wands JR, Tong SP. A short sequence within domainC of duck carboxypeptidase D is critical for duckhepatitis B virus binding and determines hostspecificity. J Virol 2001;75:10630-42.

• Dumoulin FL, von de Bussche A, Li J, Khamzina L,Wands JR, Sauerbruch T, Spengler U. Hepatitis Cvirus NS2 protein inhibits gene expression fromdifferent cellular and viral promoters in hepatic andnonhepatic cell lines. Virology 2003;305:260-6.

GASTROENTEROLOGY FELLOWSHIP PROGRAMDeparting Fellows

Geoffrey Davis, Clinical practice in Seattle, WA

Kethu Sripathy, Assistant Professor, Division of Gastroenterology, Brown Medical School

Current Fellows

Name Medical School Residency

Henry Danis U. Mass Medical Internal Medicine, Brown Medical School

Waymon Lattimore Columbia University Internal Medicine, Brown Medical School

Eric Berthiaume U. Cincinnati Dartmouth University

William Chen Jefferson Medical College Internal Medicine, Brown Medical School

Edward Pensa University of Pennsylvania George Washington University


• Parekh S, Zoulim F, Ahn S, Tsai A, Li J, Kawai S, TrepoC, Wands JR, Tong S. Genome replication, virionsecretion, and e antigen expression of naturallyoccurring hepatitis B virus core promoter mutants. JVirol 2003;77:6601-12.

Zixu Mao, M.D., Ph.D• Gong X, Tang X, Wiedmann M, Wang X, Zheng D,

Mao Z. Cdk5 inhibits the protective effects oftranscription factor MEF2 in neurotoxicity-inducedapoptosis. Neuron 2003;38:33-46.

Steven Moss, M.D.• Israel DA, Salama N, Arnold CN, Moss SF, Ando T,

Wirth H-P, Tham KT, Camorlinga M, Blaser MJ,Falkow S, Peek RM. Helicobacter pylori strain-specificdifferences in genetic content, identified bymicroarray, influence host inflammatory responses. JClin Invest 2001; 107: 611-620.

• Moss SF, Sordillo EM, Abdalla AM, Makarov V,Hanzely Z, Perez-Perez GI, Blaser JM, Holt PR.Increased gastric epithelial cell apoptosis associatedwith colonization with cagA+ Helicobacter pyloristrains. Cancer Res 2001; 61: 1406-11.

• Sordillo EM, Moss SF. Helicobacter pylori andapoptosis. Methods Enzymol 2002;358:319-34.

• Eid R, Moss SF. Helicobacter pylori infection and thedevelopment of gastric cancer. N Engl J Med 2002;346: 66.

• Eguchi H, Herschenhous N, Kuzushita N, Moss SF.Helicobacter pylori Increases Proteasome-MediatedDegradation of p27kip1 in Gastric Epithelial Cells.Cancer Res 2003 (in press).

Kittichai Promrat, M.D.• Ouyang EC, Wu CH, Walton C, Promrat K, Wu GY.

Transplantation of human hepatocytes into tolerizedgenetically immunocompetent rats. World JGastroenterol 2001;324-30.

• Soza A, Everhart J, Ghany MG, Doo E, Heller T,Promrat K, Liang TJ, Hoofnagle JH. Neutropeniaassociated with alpha interferon therapy of chronichepatitis C. 2002;36:1273-9.

• Ghany MG, Kleiner DE, Alter HJ, Doo E, Promrat K,Khokar F, Park Y, Liang TJ, Hoofnagle JH. Progressionof fibrosis in chronic hepatitis C. Gastroenterology2003;124:97-104.

• Promrat K, McDermott DH, Gonzalez C et al. Associ-ation of chemokine system polymorphisms withclinical outcomes and treatment responses of chronichepatitis C. Gastroenterology 2003;124:352-60.

• Wu CH, Ouyang EC, Walton C, Promrat K, ForouharF, Wu GY. Hepatitis B virus infection of transplantedhuman hepatocytes causes a biochemical andhistologic hepatitis in immunocompetent rats. WorldJ Gastroenterol 2003;9:978-83.

Harlan Rich, M.D.• Poorkalkhali N, Rich H, Jacobson I, Amaral J,

Migliori SJ, Chrostek CA, Biancani P, Cabero JL,Helander HF. Chronic esophagitis in the cat. Scand JGastroenterol 2001; 36:904-09

Shuping Tong, M.D., Ph.D• Spanengberg H, Lee H, Li J, Tan F, Skidgel R, Wands J,

Tong S. A short sequence within domain C of duckcarboxypeptidase D is critical for duck hepatitis Bviral binding and determines host specificity. J Virol2001; 75:10630-42.

• Parekh S, Zoulim F, Tsai A, Li J, Kawai S, Khan N,Trepo C, Wands J, Tong S. Genome replication, virionsecretion, and e antigen expression of naturallyoccurring hepatitis B virus core promoter mutants. JVirol 2003; 77:6601-12.

• Ahn SH, Kramvis A, Kawai S, Spangenberg H, Li J,Kimbi G, Kew M, Wands JR, Tong S. Sequencevariation upstream of precore translation initiationcodon reduces hepatitis B virus e antigen production.Gastroenterology (in press).

Jack Wands, M.D.• Parekh S, Zoulim F, Ahn SH, Tsai A, Li J, Kawai S,

Khan N, Trepo C, Wands JR, Tong S. Genomereplication, virion secretion, and e antigen expressionof naturally occurring hepatitis B virus core promotermutants. J Virol 2003;77(12):6601-12.

• Moradpour D, Wands JR. Molecular Pathogenesis ofHepatocellular Carcinoma. In: Hepatology: A Textbookof Liver Disease - 4th Edition. Zakim D and Boyer TD(eds) 2001.

• Xu J, Eun JY, Chang H, Tison G, Jun-Chen G, WandsJR, de la Monte, SM. Ethanol impairs insulin-stimulated neuronal survival in the developing brain:role of PTEN phosphatase. J Biol Chem 2003;279:824-31.

• Khamzina L, Gruppuso PA, Wands JR. Insulinsignaling through insulin receptor substrate 1 and 2in normal liver development. Gastroenterology 2003;125:624

• Merle P, de la Monte SM, Herrmann M, Tanaka S,Kim M, von dem Bussche A, Kew MC, Trepo C,Wands JR. Functional consequences of Frizzled-7receptor over-expression in human hepatocellularcarcinoma. Cancer Research 2003: (in press)


BASIC RESEARCH

Gyorgy Baffy, M.D.

• UCP2 In the Pathogenesis of Steatohepatitis, NIH/National Institute of Diabetes and Digestive andKidney Diseases

Jose Behar, M.D.

• Myogenic Disorders of the Gallbladder, NIH/NationalInstitute of Diabetes and Digestive and Kidney Diseases

Peiro Biancani, Ph.D.

• Inflammation and Signal Transduction inEsophagitis, NIH/National Institute of Diabetes andDigestive and Kidney Diseases

• Biophysical Principles of Peristaltic Phenomena,NIH/National Institute of Diabetes and Digestive andKidney Diseases

Weibiao Cao, Ph.D.

• COBRE - Transduction in Acid Induced Progressionof Barrett’s Esophagus (BE) From Metaplasia toDysplasia, NIH/National Center for ResearchResources

• Contractile Signal Transduction in Ulcerative Colitis,NIH/National Institute of Diabetes and Digestive andKidney Diseases

• Interleukin 1B and Contractile Signal Transduction inUlcerative, Lifespan

Suzanne de la Monte, M.D.

• Effects of Ethanol on Insulin Signaling in the Brain,NIH/National Institute on Alcohol Abuse andAlcoholism

Ji-Su Li, M.D.

• Molecular Characterization of Carboxypeptidase D,American Liver Foundation

• Role of Glycine Decarboxylase in HepadnaviralInfection, NIH/National Cancer Institute

Zixu Mao, M.D.

• Transcription-Dependent Mechanisms of NeuronalSurvival and Apoptosis in NeurodegenerativeDiseases, Rhode Island Foundation

• Calcium Dependent Survival of DevelopingNeurons, NIH/National Institute of Child Healthand Human Development

Steven Moss, M.D.

• Regulation of Gastric Epithelial p27KIP1 By H. Plyori,Foundation for Digestive Health and Nutrition

• Helicobacter Pylori and Decreased p27kipl in GastricCarcinogenesis, Concern Foundation

Shuping Tong, M.D.

• Molecular Basis for Unusual Replication andSecretion Phenotypes of Hepatitis B Virus NIH,NIAID, Lifespan

Jack Wands, M.D.

• Research Training Program in Gastroenterology,NIH/National Institute of Diabetes and Digestiveand Kidney Diseases

• Ethanol, IRS-1 Signaling and Neuronal Migration,NIH/National Institute on Alcohol Abuse andAlcoholism

• Centers of Biomedical Research Excellence (COBRE)Mechanisms of Cellular Injury, NIH

• Effects of Alcohol on the Liver, NIH/NationalInstitute on Alcohol Abuse and Alcoholism

• HBV and HCV in Alcoholics, NIH/National Instituteon Alcohol Abuse and Alcoholism

• Vascularized Tissue Sensors for Detection of GeneticToxins and Pathogens, DARPA, MassachusettsInstitute Technology

• Pathogenesis, Immunodiagnosis and Therapy ofHCC, NIH/National Cancer Institute

Zuo-Liang Xiao, M.D.

• Effects and Mechanisms of Actions of Progesterone(PG) on Human Colonic Muscle Function, Lifespan

G E N E R A L I N T E R N A L M E D I C I N E

Overview

The 2001-2003 academic years have seen growth,

achievement and change for the Division of General

Internal Medicine (DGIM). Led by Director, Michele

G.Cyr, M.D., Associate Professor of Medicine, Associ-

ate Dean for Graduate Medical Education, the division

continues to sponsor a wide array of educational,

patient care and research activities. Due to the con-

straints of space, this report will highlight but a few.

The DGIM faculty includes 17 Full Time Faculty and

143 Clinical/Part-time Faculty. During the academic

years 2001-2003, 3 Full-time Faculty and 19 Clinical

Faculty joined the division while 2 Full time Faculty

and 18 Clinical Faculty departed. Our faculty

maintain thriving clinical practices and serve as

administrators, dedicated educators, and successful

researchers at all 5 of the Brown Medical School’s

Affiliated Hospitals in Rhode Island – Rhode Island

Hospital, Memorial Hospital of Rhode Island, The

Miriam Hospital, Veterans Administration Medical

Center and Women & Infants’ Hospital.

Medical education, a chief aspect of the Division’s

mission and purpose, is conducted at the 5 Brown

Affiliated Hospitals and involves the training of more

than 200 residents. Each year, 64 interns are recruited

into the 5 Medicine Residencies. This year, 54

residents completed 3 or 4 years of training and have

gone on to fellowships, chief residencies, clinical

practices, and clinician educator positions in a variety

of settings including community-based practice,

hospitalist practice and public health. 11 interns

completed the 1-year program and entered into

specialty programs with a firm foundation in internal

medicine. 2 General Internal Medicine Fellows

completed their program in June 2002.

GIM faculty serve as the attendings for the in-patient

general medicine teaching rotations providing bedside

rounds, noon conference lectures, feedback, and

evaluation to the residents and medical students.

Furthermore, nearly 50 General Internal Medicine

Community Physician faculty and 30 Sub-specialty

faculty members served this year as preceptors in the

our Community-Based Teaching program providing a

GENERAL INTERNAL MEDICINE

second site continuity ambulatory experience for the

2nd and 3rd Year Residents. Residents generally see

patients at their second site once per week during

non-critical care unit months.

The Brown Medical School students play a significant

role in the division and in the Department of

Medicine through their participation in core clerk-

ships and sub-internships guided by division faculty.

Mark Fagan, M.D. serves as the Medical Clerkship

Director for Brown and has been elected President of

the National Organization of Clerkship Directors of

Internal Medicine. Many students choose to work

with our faculty on research projects, clinical electives

or community-based practices.

Several significant facility moves and renovations

marked 2001-2003 in both the educational and

patient care environments. The Medicine-Pediatrics

Primary Care Center (MPPCU), an integrated

Medicine-Pediatrics faculty-resident practice relocated

to Coro West, a renovated medical office building on

the Rhode Island Hospital/Hasbro Children’s Hospital

Campus that provides residents with their main

ambulatory continuity experience. The practice is a

thriving one and the Med-Peds residents work in

partnership with their faculty preceptors. A continuity

student rotation, led by Dr. Sybil Cineas, Course

Director was also initiated this year. In addition, the

MPPCU serves as the base study center for several

resident-faculty clinical research collaborations, most

recently involving patient education in the care of

diabetes. Families come from neighboring communi-

ties and have diverse ethnic and socioeconomic

backgrounds.

The Rhode Island Hospital academic offices of the

Division and the Internal Medicine Residency Pro-

grams’ offices also relocated in May 2002 to renovated

space in the Jane Brown Building. This move has

provided greater availability to the internal medicine

residents and convenient access to inpatient care areas.

Moreover, these moves freed up the much-needed

space for the expansion of our DGIM Research Unit.


The DGIM Research Unit, directed by Michael Stein,

M.D., moved into and refurbished the first floor of the

Multiphasic Building, allowing for faculty expansion.

Four new faculty researchers were recruited to the

research unit. Dr. Jennifer Clarke, a graduate of

Brown’s residency program and General Internal

Medicine Fellowship joined the faculty. Dr. Clarke’s

research interests include women’s health, substance

abuse and health services research. Her clinical and

administrative time is spent at the Rhode Island

Women’s Adult Correctional Institute. Dr. Clarke has

already received federal funding to study women in

prison, unplanned pregnancies and sexually

transmitted diseases. Dr. Susan Ramsey, a clinical

psychologist, moved over from Butler Hospital to join

the division. Her research interest involves patients

with comorbid substance abuse and psychiatric

disorders. Dr. Cynthia Rosengard, a

clinical psychologist who completed

her post-doctoral fellowship at

University of California, San

Francisco, arrived to start a research

program in adolescent health and

behavior, with a special interest in

determinants of sexual risk-taking.

Dr. Mark Schleinitz was recruited

from Stanford University, where he

recently completed a fellowship in

Health Research and Policy. His

expertise involves applying cost-

effectiveness and meta-analytic

techniques to a variety of clinical

problems in cardiovascular

medicine. In addition, Patricia Cioe,

RNP has also joined the division,

expanding the HIV and hepatitis

clinical and research programs

based in DGIM and the Medical

Primary Care Unit, and

coordinating clinical trials there.

Michele G. Cyr, M.D., Associate

Professor of Medicine; Associate

Dean for Graduate Medical

Education; Director, Division of

General Internal Medicine

Our Hospitalist Program, the first program of its kind

in Rhode Island, continues to provide high quality,

cost effective inpatient care at Rhode Island Hospital,

while allowing community-based physicians to use

their time more efficiently in the office. Since 1996,

the service has grown to include a medical staff of 6

physicians and 2 nurse practitioners with plans for

future expansion. This year the program relocated to

renovated space in the Rhode Island Hospital Main

Building’s Penthouse. Coverage is provided 24 hours

per day, 7 days per week.

Finally, General Internal Medicine, the largest division

in the Department of Medicine is pleased and very

proud to report on a year of continued progress in

pursuit of our goals for excellence in education,

clinical care, and research administration.


Faculty Members

FULL-TIME FACULTY

(Hospital or Foundation Based)

Michele G. Cyr, M.D., Director, Associate Professor,Rhode Island Hospital, University MedicineFoundation

Mel Anderson, M.D., Clinical Assistant Professor, VAMC

Lynn Bowlby, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Amos Charles, M.D., Clinical Instructor, VA MedicalCenter

Jennifer Clarke, M.D., Assistant Professor, Rhode IslandHospital, University Medicine Foundation

Robert Crausman, M.D., Associate Professor ofMedicine, Memorial Hospital

Mark J. Fagan, M.D., Associate Professor, Rhode IslandHospital, University Medicine Foundation

Sybil Cineas, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Joseph Diaz, M.D., Assistant Professor, MemorialHospital

Peter Friedmann, M.D. M.P.H., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

*David R. Gifford, M.D. M.P.H., Assistant Professor,Rhode Island Hospital/Geriatrics, UniversityMedicine Foundation

Debra S. Herman, Ph.D., Clinical Assistant Professor,Rhode Island Hospital

Jennifer Jeremiah, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Douglas Kiel, M.D. Ph.D., Adjunct Associate Professor,Rhode Island Hospital, University MedicineFoundation

**Lucia Larson, M.D., Assistant Professor, Rhode IslandHospital/Women & Infants

Michael Maher, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Kelly McGarry, M.D., Assistant Professor, Rhode IslandHospital, University Medicine Foundation

Anne W. Moulton, M.D., Associate Professor, RhodeIsland Hospital, University Medicine Foundation

Jose Polanco, M.D., Director, Notre Dame AmbulatoryCare Center, Clinical Instructor, Memorial Hospital

Roy Poses, M.D., Associate Professor, Memorial Hospital

Susan E. Ramsey, Ph.D., Assistant Professor of Research,Rhode Island Hospital, University Medicine Foundation

Cynthia Rosengard, Ph.D., Assistant Professor, RhodeIsland Hospital

Benjamin Sapers, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Mark D. Schleinitz, M.D., M.Sc., Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Jack Schwartzwald, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Michael D. Stein, M.D., Associate Professor, RhodeIsland Hospital

Michelle Stozek, M.D., Clinical Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Dominick Tammaro, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Iris Tong, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

UNIVERSITY MEDICINE FOUNDATIONPRIMARY CARE

Francis Basile, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Kim Basu, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Karen Blackmer, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Thomas Bledsoe, M.D., Clinical Associate Professor,Rhode Island Hospital, University MedicineFoundation

Paul Breiding, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Stefano Cazzaniga, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Michael Felder, D.O., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Sajeev Handa, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Michael Hayden, D.O., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Christine Herbert, M.D., Ph.D., Clinical AssistantProfessor, Miriam Hospital, University MedicineFoundation

David A. Herec, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

S. Iftikihar Hussain, M.D., Clinical Instructor, MiriamHospital, University Medicine Foundation


Michael Johnson, M.D., Clinical Assistant Professor,Rhode Island Hospital, University Medicine Foundation

Warren Licht, M.D., Clinical Assistant Professor,Miriam Hospital, University Medicine Foundation

Steven Mallozzi, M.D., Clinical Assistant Professor,Miriam Hospital, University Medicine Foundation

Jacqueline Michaud, M.D. Clinical Instructor, RhodeIsland Hospital, University Medicine Foundation

Jennifer Maude, M.D., Clinical Instructor, MiriamHospital, University Medicine Foundation

Louis Moran, D.O., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Lina Nemchenok, M.D., Clinical Instructor, RhodeIsland Hospital, University Medicine Foundation

Mariola Nowak, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Sara Nugent, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Gail M. O’Brien, M.D., Clinical Associate Professor,Rhode Island Hospital

Laura Ofstead, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Jeanne Oliva, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Anne Spaulding, M.D., Clinical Assistant Professor,Rhode Island Hospital, University MedicineFoundation

Edward Stulik, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

James Sullivan, M.D., Clinical Assistant Professor,Miriam Hospital, University Medicine Foundation

Lewis Weiner, M.D., Clinical Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Tony Wu, M.D., Clinical Instructor, Rhode Island Hospital

Hugo M. Yamada, M.D., Clinical Instructor, RhodeIsland Hospital, University Medicine Foundation

VOLUNTEER FACULTY

Theophilus Addo, M.D., Clinical Instructor, NewportHospital

Paul Agatiello, M.D., Clinical Instructor, MemorialHospital

Khaja Ahmed, M.D. CHE, Clinical Assistant Professor,VA Medical Center

Scott Allen, M.D., Clinical Assistant Professor, MiriamHospital

Motasem Al-Yacoub, M.D., Clinical Instructor,Memorial Hospital

Ahmad Al-Raqqad, M.D., Clinical Instructor, Memorial

Kim Amin, M.D., Clinical Assistant Professor, MemorialHospital

Mel Anderson, M.D., Clinical Assistant Professor, VAMedical Center

Rex Appenfeller, M.D., Clinical Assistant Professor,Miriam Hospital

Daniel Asiedu, M.D., Ph.D., Clinical Instructor, MiriamHospital

Jeffrey Austerlitz, M.D., Clinical Instructor, RhodeIsland Hospital

Munawar Azam, M.D., Clinical Instructor, St. Joseph’sHospital

Kaku Badoe, M.D., Clinical Assistant Professor, MiriamHospital

Jeffrey Baron, M.D., Clinical Instructor, MemorialHospital

Anne Bauman, M.D., Clinical Instructor, MemorialHospital

Carolyn Blackman, M.D., Clinical Instructor, RhodeIsland Hospital

Dawna Blake, M.D., Clinical Assistant Professor, VAMedical Center

Mark Braun, M.D., Clinical Assistant Professor, RogerWilliams Medical Center

C. John Brex, M.D., Clinical Instructor, Rhode IslandHospital

Steven Brin, M.D., Clinical Instructor, Rhode IslandHospital

Gary Bubly, M.D., Clinical Assistant Professor, MiriamHospital

Robert Burroughs, M.D., Clinical Assistant Professor,Memorial Hospital

James Cardi, M.D., Clinical Instructor, Rhode IslandHospital

Hector Castro, M.D., Clinical Professor of Medicine,Memorial Hospital

Dana Chofay, M.D., Clinical Instructor, Rhode IslandHospital

Evan Cohen, M.D., Clinical Assistant Professor, MiriamHospital

Reid Coleman, M.D., Clinical Associate Professor,Miriam Hospital

Joyce Coppola, M.D., Clinical Assistant Professor,Memorial Hospital

Frederick Crisafulli, M.D., Clinical Associate Professor,Miriam Hospital

Anne Cushing-Brescia, M.D., Clinical Instructor,Miriam Hospital

Kwame Dapaah-Afriyie, M.D., Clinical AssistantProfessor, Miriam Hospital

Allen Dennison, M.D., Clinical Assistant Professor,Rhode Island Hospital


Hector Derreza, M.D., Clinical Instructor, MiriamHospital

Ghandi Drak, M.D., Clinical Instructor, MemorialHospital

Jeffrey Drogin, M.D., Clinical Instructor, Rhode IslandHospital

Lata Eapen, M.D., Clinical Instructor, VA MedicalCenter

Yul Ejnes, M.D., Clinical Associate Professor, RhodeIsland Hospital

Peter Eller, M.D., Clinical Assistant Professor, MiriamHospital

Andrea Flory, M.D., Clinical Instructor, Rhode IslandHospital

Bruce Fischer, M.D., Clinical Instructor, Rhode IslandHospital

Keith Fish, M.D., Clinical Instructor, Miriam Hospital

David Fried, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Denise Glickman, M.D., Clinical Assistant Professor,Rhode Island Hospital

Walter Goula, M.D., Clinical Instructor, MiriamHospital

R. Scott Hanson, M.D., M.P.H., Clinical AssistantProfessor, Rhode Island Hospital

Pamela Harrop, M.D., Clinical Assistant Professor,Rhode Island Hospital

Donald Hebb, M.D., Clinical Instructor, Kent CountyHospital

Hector Castro, M.D., Clinical Assistant Professor,Memorial

Melvin Hershkowitz, M.D., Clinical Assistant Professor,Miriam Hospital

Peter Hollmann, M.D., Clinical Assistant Professor,Roger Williams Medical Center

Guang Hu, M.D., Clinical Instructor, VA Medical Center

Henry Izeman, M.D., Clinical Associate Professor,Miriam Hospital

Mark Jacobs, M.D., Clinical Assistant Professor, MiriamHospital

Steven Kempner, M.D., Clinical Assistant Professor,Miriam Hospital

Martin Kerzer, D.O., Clinical Instructor, Roger WilliamsMedical Center

David Kerzer, D.O., Clinical Instructor, MiriamHospital

Sree Kesan, M.D., Associate Residency Director andDirector of Hospitalist Service, Clinical AssistantProfessor, Memorial Hospital

Mohammad Khan, M.D., Clinical Assistant Professor,Memorial Hospital

Razib Khaund, M.D., Clinical Assistant Professor,Miriam Hospital

William Kirkpatrick, Clinical Teaching Associate,Miriam Hospital

David Kitzes, M.D., Clinical Associate Professor, MiriamHospital

Thomas Krahn, M.D., Clinical Assistant Professor,Rhode Island Hospital

Chi Kuang Lai, M.D., Clinical Assistant Professor, VAMedical Center

Carlos Lira, M.D., Clinical Instructor, MemorialHospital

Nancy Littell, M.D., M.P.H., Clinical Assistant Professor,Rhode Island Hospital

Kapildeo Lotun, M.D., Clinical Instructor, MiriamHospital

Hua Chung Lu, M.D., Clinical Instructor, Rhode IslandHospital

Michael Macko, M.D., Clinical Associate Professor, VAMedical Center

Samir Makarious, M.D., Clinical Assistant Professor,Miriam Hospital

Timothy Manown, M.D., Clinical Instructor, KentCounty Hospital

Fadi Mansourati, M.D., Director Internal MedicineCenter, Clinical Assistant Professor, MemorialHospital

Vincent Marcaccio, M.D., Clinical Instructor, RogerWilliams Medical Center

David Marcoux, M.D., Clinical Assistant Professor,Miriam Hospital

Patricia Marshall, Ph.D., Clinical Teaching Associate,Memorial Hospital

Edward Martin, M.D., Clinical Assistant Professor,Roger Williams Medical Center

Robert Mathieu, M.D., Clinical Instructor, MiriamHospital

Steven McCloy, M.D., Clinical Assistant Professor,Miriam Hospital

John Miskovsky, M.D., Clinical Assistant Professor,Memorial Hospital

Richard Morgera, M.D., Clinical Instructor, MiriamHospital

Kathleen Morton, M.D., Clinical Assistant Professor,Memorial Hospital

Paul Murphy, M.D., Clinical Assistant Professor, VAMedical Center

Vito Longobardi, M.D., Clinical Instructor, Memorial

Edward Olchowski, M.D., Clinical Assistant Professor,Miriam Hospital


Albert Osei, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Yogesh Pancholi, M.D., Clinical Instructor, MemorialHospital

Terry Patinkin, M.D., FACEP, Clinical AssistantProfessor, Roger Williams Medical Center

Vincent Pera, M.D., Clinical Assistant Professor, MiriamHospital

Raymond Petit, M.D., Clinical Assistant Professor,Rhode Island Hospital

Peter Petropoulos, M.D., Clinical Assistant Professor,VA Medical Center

Soneath Pond, M.D., Clinical Instructor, Roger WilliamsMedical Center

Mitchell Pressman, M.D., Clinical Instructor, RhodeIsland Hospital

Anthony Ricci, M.D., Clinical Instructor, MiriamHospital

Tina Rizack, M.D., Clinical Instructor, Memorial Hospital

Fredy Roland, M.D., Clinical Assistant Professor,Memorial Hospital

Richard Ruggieri, M.D., Clinical Assistant Professor,Miriam Hospital

Patricia Russo-Magno, M.D., Clinical AssistantProfessor, Memorial

Richard Ryter, M.D., Clinical Assistant Professor, RogerWilliams Medical Center

Larry Schoenfeld, M.D., Clinical Assistant Professor,Miriam Hospital

Howard Schulman, M.D., Clinical Assistant Professor,Miriam Hospital

Stephen Scott, M.D., Clinical Instructor, Rhode IslandHospital

Russell Settipane, M.D., Clinical Assistant Professor,Rhode Island Hospital

Parviz Shavandy, M.D., Clinical Instructor, VA MedicalCenter

Michael Siclari, M.D., Clinical Assistant Professor,Roger Williams Medical Center

Diane Siedlecki, M.D., Clinical Instructor, MiriamHospital

Julie Smail, M.D., Clinical Instructor, MemorialHospital

Jean Smith, M.D., Clinical Instructor, Miriam Hospital

Lynn Sommerville, M.D., Ph.D. Clinical AssistantProfessor, Miriam Hospital

Josef Sternberg, M.D., Ph.D. Clinical AssistantProfessor, VA Medical Center

John Stoukides, M.D., Clinical Assistant Professor,Roger Williams Medical Center

Edward Wheeler, M.D., Clinical Assistant Professor,Rhode Island Hospital

Madhavi Yerneni, M.D., Clinical Instructor, MiriamHospital,

Nidal Yunis, M.D., Clinical Assistant Professor,Memorial Hospital

Vladislav Zayas, M.D., Clinical Instructor, MiriamHospital

Flora Treger, M.D., Clinical Instructor, Rhode IslandHospital

Caroline Troise, M.D., Ph.D. Clinical AssistantProfessor, Miriam Hospital

Philip Vaidyan, M.D., Clinical Instructor, MiriamHospital

Todd Viccione, M.D., Clinical Instructor, Rhode IslandHospital

Barbara Weil, M.D., Clinical Instructor, VA MedicalCenter

Karen Woolfall-Quin, M.D., Clinical Instructor, VAMedical Center

* Joint appointment in Geriatrics

**Joint appointment in Obstetric & Consultative Medicine


FACULTY TRANSITIONS

Departing Faculty

Robert Burroughs, M.D., Clinical Assistant Professor, Memorial HospitalBarbara Tate, PhD Adjunct Assistant Professor (Rsch), BrownKeith Fish, M.D., Clinical Instructor, The Miriam HospitalGeorge Gleva, M.D., Clinical Instructor, Memorial HospitalLinda Jordan, MSN, Clinical Teaching Associate, Memorial HospitalDavid Kerzer, DO, Clinical Instructor, The Miriam HospitalMartin Kerzer, DO, Clinical Instructor, The Miriam HospitalRobert Mathieu, M.D., Clinical Instructor, The Miriam HospitalFelicia Meila, M.D., Clinical Instructor, The Miriam HospitalKathleen Morton, M.D., Clinical Assistant Professor, The Miriam HospitalEdward Olchowski, M.D., Clinical Assistant Professor, The Miriam HospitalAlbert Osei, M.D., Clinical Assistant Professor, Rhode Island HospitalRichard Ryter, M.D., Clinical Assistant Professor, Roger WilliamsWilliam Sabina, M.D., Clinical Instructor, Rhode Island HospitalJulie Smail, M.D., Clinical Instructor, Memorial HospitalAnne Spaulding, M.D., Clinical Assistant Professor, Rhode Island HospitalNidal Yunis, M.D., Assistant Professor, Memorial Hospital

New Faculty


Mel Anderson, M.D. Preceptor: UC Davis Clinical Assistant Professor,Medical School 1997-2000 VAMC

Lynn Bowlby, M.D. New Bedford Medical Associates,1995-2000

Rehabilitation Hospital of Clinical Instructor, RIHRhode Island, 1999-2002

Jennifer Clarke, M.D. Women’s Health Fellow, Assistant Professor, RIHBrown Medical School

Joseph Diaz, M.D. Fellowship: Brown, RIH Assistant Professor, Memorial

Debra Herman, Ph.D. Research Project and Clinical Assistant Professor, RIHDevelopment Assistant

Jose Polanco, M.D. Resid. RIH 6/98-6/01 Clinical Instructor, Memorial

Cynthia Rosengard, Ph.D. Assistant Professor at Pacific Graduate Assistant Professor (Res.)School of Psych

Benjamin Sapers, M.D. Staff Internist, University Medical Clinical Assistant Professor, RIHAssociates

Mark Schlienitz, M.D., M.S. Staff Physician: Palo Alto, VA Assistant Professor, RIHHealthcare System

Michelle Stozek, M.D. Chief Medical Resident, Clinical Assistant Professor, RIHBrown Medical School

Iris Tong, M.D. Chief Medical Resident, Clinical Instructor, RIHBrown Medical School

Foundation Based Primary Care Faculty

Jennifer Maude, M.D. Clinical Instructor, Miriam

Paul Breiding, M.D. Locum Tenens Physician for Clinical Instructor, MiriamCompHealth 1999


Volunteer Faculty

Name Faculty Rank Former Position

Theophilus Addo, M.D. Clinical Instr., Newport Hospital Anne Arundel Med. Ctr. 3/00-10/01

Sudeep Aulakh, M.D. Clinical Assist. Professor, RIH Teaching Fellow, Brown, 1997-2000

Carolyn Blackman, M.D. Clinical Instructor, R.I. Hospital Chief Resid. Brown Univ. GIM 00-01

Ahmad Al-Raqqad, M.D. Clinical Instructor, Memorial Hospital Chief Resident, Brown Medical Sch.,Primary Care Residency Program

Motasem Al-Yacoub, M.D. Clinical Instructor, Memorial Hospital (TERMINATED)

Kim Amin, M.D. Clin. Assist. Professor, Memorial Hosp. Chief Resident, Brown Medical Sch.,Internal Medicine Residency Prog.

Jeffrey Baron, M.D. Clinical Instructor, Memorial Hospital Resident, Brown Medical School,Internal Medicine Residency Prog.

Anne Bauman, M.D. Clinical Instructor, Memorial Hospital Attending Physician, GIM

Hector Castro, M.D. Clinical Assist. Prof., Memorial Hospital Hospitalist-Teaching Physician,Internal Medicine

Joyce Coppola, M.D. Clinical Assist. Prof., Memorial Hospital Attending Physician, GIM

Ghandi Drak, M.D. Notre Dame Ambulatory Ctr.; Clin. Instr., Memorial HospitalResid: RWMC 97-00

Andrea Flory, M.D. Clinical Instructor, RIH Resid. RIH 1999-2001

Sadia Iftikhar, M.D. Clinical Instructor, Memorial Hospital Post-Doctoral Research FellowshipUniversity of PennsylvaniaSchool of Medicine 1997-98

Sree H. Khan, M.D. Clin. Assist. Prof., Memorial Hosp.

Carlos Lira, M.D. Clinical Instructor, Memorial Hosp.

Vito Longobardi, M.D. Clinical Instructor, Memorial Hosp.

Kapildeo Lotun, M.D. Clinical Instructor, Miriam Hospital Resid New England Medical Ctr/Tufts University, 99-00

Fadi Mansourati, M.D. Clinical Assist. Prof., Memorial Hosp. Notre Dame Ambulatory Care Ctr.

Patricia Marshall, Ph.D. Clinical Teaching Associate, Memorial Chief Resident, Brown Medical Sch.,Spanish Internal/Peds. Resid. Prog.

John Miskovsky, M.D. Clinical Assist. Prof., Memorial Hospital Chief Resident, Brown Medical Sch.,Internal Medicine

Yogesh Pancholi, M.D. Clinical Instructor, Memorial Hospital Attending Physician, GIM

Tina Rizack, M.D. Clinical Instructor, Memorial Hospital Resident, The University of ChicagoHospitals, Internal Medicine

Fredy Roland, M.D. Clinical Assist. Prof., Memorial Hosp.

Patricia Russo-Magno, M.D. Clinical Assist. Prof., Memorial Hosp. Attending Physician, Pulm/CC

Yogesh Pancholi, M.D. Resid: Univ. of Rochester 1997-2000 Clin. Instr., Memorial Hospital

Tina Rizack, M.D. Resid: The Univ. of Chicago Hospitals Clin. Instr., Memorial Hospital

Parviz Shavandy, M.D. Charlton Memorial Hospital, St. Anne’s Clin. Instr., VAMCHospital 7/94

Lahey Clinic Fall River 10/9

Jean Smith, M.D. Medicine Associates, Ltd. 1996 Clin. Instr., Miriam Hospital

Flora Treger, M.D. Multispecialty group for women 1992 Clin. Instr., RIH

Madhavi Yerneni, M.D. TMH 1999 Clin. Instr., Miriam Hospital


National andInternational Honorsand Recognition

Michele G. Cyr, M.D.• Perishable Theater’s Board of Directors Influential

Women of Rhode Island Award, 2002

• Outstanding Woman in Science Award, Providence,2001


• “Managing Menopause,” American College ofPhysicians, American Society of Internal MedicineAnnual Meeting, Philadelphia, PA, April 2002

• “Meet the Professor,” American College of Physicians,American Society of Internal Medicine AnnualMeeting, Philadelphia, PA, April 2002

• “Getting Through the Match,” American College ofPhysicians, American Society of Internal MedicineAnnual Meeting, Philadelphia, PA, April 2002

• “Building a Career as a Clinician Educator andAdministrator,” SGIM Regional Meeting, Beth IsraelDeaconess Medical Center, March 2002.

• “Menopause Town Meeting: Everything You Need toKnow,” Health New England’s “Celebrating Women”Series, Springfield, MA, September 2002.

• “Benefits and Risks of Hormone ReplacementTherapy,” The Comprehensive Cancer Center –American Cancer Society’s “Food for the Fight – Getthe Facts About Breast Cancer” Program, Providence,RI, Oct. 2002.

• “The Pros & Cons of Hormone Therapy,” TheDepartment of Food and Nutrition Services’ TwelfthAnnual Nutrition Symposium

• “Contemporary Topics In Nutrition,” Providence, RI,March 27, 2003.

• “The Role of Negotiation in Career Advancement forWomen in Medicine,” The Office of Women inMedicine Workshop, Providence, RI, May 12, 2003.

• “Menopausal Hormone Therapy: Where Are WeNow?,” Brown Medical School’s 1st Annual Update inInternal Medicine, Providence, RI, May 16, 2003.

• “What Every Woman Should Know About Women’sHealth,” American Association for UniversityWomen’s National Conference for College WomenStudent Leaders (NCCWSL) and the Convention ofthe American Association of University Women,Providence, RI, June 21, 2003.

• “Meet and Eat with the Professor – Tutorial,”American College of Physicians -American Society of

Internal Medicine 84th Annual Session,Philadelphia, PA, April 4, 2003.

• “Getting Through the Match,” American College ofPhysicians – American Society of Internal Medicine84th Annual Session, Philadelphia, PA, April 4, 2003.

• “Menopause Hormone Therapy: Where Are WeNow?,” American College of Physicians – AmericanSociety of Internal Medicine 84th Annual Session,Philadelphia, PA, April 4, 2003.

• “Menopausal Hormone Therapy: Where Are WeNow?,” Brown Medical School’s Department ofMedicine: Update in Internal Medicine, Providence,RI, May 16, 2003.

• “Menopause Treatments in the Wake of WHI,”Update on Women’s Issues – Medical GrandRounds, Rhode Island Hospital, Providence, RI,May 20, 2003.

Joseph A Diaz, M.D.Invited Presentations:

• “Impact of Interpretation Methods on Clinic VisitLength,” Society of General Internal MedicineAnnual Meeting, Atlanta, GA, 2002

• “Impact of Trainee Level on Clinic Visit Length,”Clerkship Directors in Internal Medicine NationalMeeting, Washington, DC, October 2002

• “Evaluation of Patient Satisfaction in a MedicationAssistance Program (MAP),” Society of GeneralInternal Medicine Annual Meeting, Vancouver, BC,May 2003

• “Sample Medication Use in Internal MedicineTeaching Clinic: A National Survey,” Society ofGeneral Internal Medicine, Annual Meeting,Vancouver, BC, May 2003

• “Reasons Why Patients Use the Internet:Information Seeking and Decision-Making,” Societyof General Internal, Medicine Annual Meeting,Vancouver, BC, May 2003.

Mark J. Fagan, M.D.• President, National Clerkship Directors in Internal

Medicine (CDIM)


• “The Internal Medicine SubInternship: ACurriculum Needs Assessment,” Society of GeneralInternal Medicine National Meeting, Atlanta, GA,May 2002

• “Impact of Interpretation Methods on Clinic VisitLength,” Society of General Internal MedicineNational Meeting, Atlanta, GA, May 2002

• “Resident Teaching Clinics: Recent innovations andMeeting Challenges of the Next 25 Years,” Society ofGeneral Internal Medicine National Meeting,Atlanta, GA, May 2002


Peter D. Friedmann, M.D., MPH• Master of Arts, ad eundem, Brown University,

Providence, RI, May 23, 2003.

• Bruce M. Selya Award for Research Excellence,Lifespan Hospitals, November 8, 2002.

• Best Workshop Award for “Primecare: PromoteRecovery in Medical Care,” 25th Annual NationalMeeting of the Association for Medical Educationand Research in Substance Abuse, 2002

• Invited to serve as a national mentor in the CSAT/SAMHSA Interdisciplinary Program to ImproveHealth Professional Education in substance abuse.

• Guest Associate Editor, Journal of General InternalMedicine, Special Issue – Substance Abuse:Innovations in Primary Care, 2002


• “Screening, Assessment, Intervention and Referral,”HRSA-AMERSA-CSAT/SAMHSA InterdisciplinaryProgram to Improve Health Professional Educationin Substance Abuse, Baltimore, M.D., 2002

• “Grant Writing,” HRSA-AMERSA-CSAT/SAMHSAInterdisciplinary Program to Improve HealthProfessional Education in Substance Abuse, ProjectMAINSTREAM Northeast Regional Meeting,Providence, RI, 2002

• “Maintenance Care and Relapse Prevention forSubstance-Related Disorders in Remission,” Society ofGeneral Internal Medicine 25th Annual Meeting,Atlanta, GA, 2002

• “Maintenance Care and Relapse Prevention forSubstance-Related Disorders in Remission,” GrandRounds, Boston Healthcare for the HomelessProgram, Boston, MA, 2002

Carol Landau, PhD• Editorial Board member, Menopause Management

• Medical Advisory Board, Wellness Council ofAmerica, Omaha, NB, 2001-present

• Chair, Clinical Appointment and PromotionsCommittee, Brown University Department ofPsychiatry and Human Behavior

• Past President, Rhode Island PsychologicalAssociation


• “Menopause Town meeting: Everything You Need ToKnow,” Celebrating Women Series, Health NewEngland, Springfield, MA, September 2002.

• “Menopause Monologues,” Brown LearningCommunity, Brown University, April 2002.

• “Depression in College Students,” Mental HealthAwareness Day, Brown University, March 2002.

• “Current Issues in Women’s Health: Doctor-PatientCommunications,” Meeting of the American

Association of University Women, Providence, RI,June 2003.

Kelly A. McGarry, M.D.• Top Doctor for Women, Rhode Island Monthly, 2003

• Board member, University Medicine Foundation, 2002

• Profile in Competence Award – Moral Reasoning andEthics, Brown Medical School medical students, May2002

• Co-investigator, Lesbian Health Fund


• “Menopause Monologues,” Brown LearningCommunity, Brown University, April 2002.

• “Osteoporosis: Practical Issues for Treating YourPatients,” Women in Medicine Conference,Burlington, VT, July 2002

• “Getting Through the Match,” American College ofPhysicians, American Society of Internal MedicineAnnual Meeting, Philadelphia, PA, April 2002

Anne Moulton, M.D.Invited Presentations:

• “Menopause Town meeting: Everything You Need ToKnow,” Celebrating Women Series, Health NewEngland, Springfield, MA, September, 2002.

Roy Maurice Poses, M.D.• Consultant, Clinical Judgment Analysis Pilot Project

Task Force, National Board ofºMedical Examiners,Philadelphia, PA, 2002-2003

• Chair, Development Committee, Society for MedicalDecision Making, 1999-2002

• Chair, Health Services Research III Subcommittee,Scientific Program Committee, Society for GeneralInternal Medicine, 2002

• Member, Special Emphasis Panel, Clinical Informaticsto Promote Patient Safety, Agency for Health CareResearch and Quality, 2001

• External Reviewer, Sheikh Hamdan bin Rashid AlMahtoum Award for the Best Medical College/Institute in the Arab World, 2002

• Biography, “Who’s Who in America,” 2000-2002

• Named as one of the “Top 5% of all reviewers in lastfive years,” Medical Care, 2001

• Eugene Saenger Award for Distinguished Service,Society for Medical Decision Making, 2001


• “Healing the Schism, Again? -Medicine vs. PublicHealth.” Special Seminar, Department of PreventiveMedicine and Community Health, VCU-MedicalCollege of Virginia, Richmond, VA, July, 2001

• Faculty, Course on Changing Physician Behavior,Annual Meeting of the Society for Medical DecisionMaking, San Diego, CA, October, 2001


• Coordinator and Faculty, Course on Conflict ofInterest and Research Integrity, Annual Meeting ofthe Society for Medical Decision Making, San Diego,CA, October, 2001

• “Toma de Decisiones en UCI [ICU Decision Making]a Simposio: Terapia en Cuidado Intensivo[Symposium: Therapy in the Intensive Care Unit,”Departmento de Medicina Interna, Facultad deMedicina, Pontificia, Universidad Javeriana, Bogota,Columbia, February, 2002

• “Falla Cardiaca Congestiva.” [Congestive HeartFailure]. Curso: Terapeútica en el Paciente Aguda-mente Enfermo. [Course on Therapeutic in theAcutely Ill Patient],” Departmento de MedicinaInterna, Facultad de Medicina, Pontificia, UniversidadJaveriana, Bogota, Columbia, February, 2002

• “Terapia Medicinal del Infarto Agudo de Miocardio.”[Medical Therapy of Acute Myocardial Infarction],”Department of Internal Medicine, UniversidadJaveriana, Bogota, Columbia, Departmento de Medi-cina Interna, Facultad de Medicina, Pontificia, Uni-versidad Javeriana, Bogota, Columbia, February, 2002

• Faculty, Course on Changing Physician Behavior,Annual Meeting of The Society for Medical DecisionMaking. Baltimore, M.D., 2002

• Lecturer, “Cognition and Implementation ofEvidence-Based Medicine,” Clinical EpidemiologySeminar, Ottawa Health Research Institute, Universityof Ottawa, Ottawa, Ontario, Canada, 2002

Susan E. Ramsey, Ph.D.Invited Presentations:

• “PRIMECare: Promote recovery in medical care,” 25th

Annual AMERSA National Conference, Alexandria,VA, 2002

• “What predicts mental health treatment adherenceamong injection drug users?” Association for Advance-ment of Behavior Therapy, Philadelphia, PA, 2002

• “Validation of the balloon analogue risk task (BART)for assessing real world risky behaviors,” Associationfor Advancement of Behavior Therapy, Philadelphia,PA, 2002

• “Exercise attitudes and behaviors in individuals withalcohol use disorders,” Association for Advancementof Behavior Therapy, Philadelphia, PA, 2002

• “Nicotine dependence among adolescents withpsychiatric disorders: Evaluating symptom expressionas a function of dependence severity,” presented at theSociety for Research on Nicotine and Tobacco,Savannah, GA, 2002

• “Validation of the balloon analogue risk task (BART)for assessing real world risky behaviors,” presented atthe Association for Advancement of BehaviorTherapy, Philadelphia, PA, 2002

Cynthia Rosengard, Ph.D.• Chair, Membership Committee, Division 38 (Health

Psychology), American Psychological Association

Invited Presentation:

• “The relationship of general perceived self-efficacy,health locus of control, and health value to health riskbehavior among adolescents,” Society for Research onChild Development. Tampa, FL, April 2003

• “Health locus of control, health value, self efficacy,and acculturation status in predicting health riskbehaviors among Latino adolescents,” LatinoPsychology Conference, Providence, RI, October 2002

• “Partner-specific factors in adolescent sexualbehavior,” Center for HIV Intervention andPrevention (CHIP), brown bag lecture series, Storrs,CT, October 2002

Mark D. Schleinitz, M.D., MSc• Milton W. Hamolsky Junior Faculty Award for the

most outstanding scientific presentation, Society ofGeneral Internal Medicine, 26th Annual Meeting,Vancouver, BC, May 2003.


• “Clopidogrel plus aspirin or aspirin alone for highrisk patients with unstable angina: a cost-effectivenessanalysis,” Society of General Internal Medicine, 26th

Annual Meeting, Vancouver, BC, May 2003.

Michael D. Stein, M.D.• Midcareer Investigator Award from the National

Institute on Drug Abuse. This distinction providessupport for mentoring junior faculty as well as for theexpansion of innovative research.


• “Reducing Sexual Risk for Substance UsingHeterosexual Men,” Center for Disease Control,January 2002

Dominick Tammaro, M.D.• Associate Chief for Clinical Affairs for the Depart-

ment of Medicine, Rhode Island Hospital, 2003

• Nominee/Finalist, Accreditation Council forGraduate Medical Education Parker J. Palmer“Courage to Teach” Award, 2002


• “Medical Care of the Perioperative Patient,” GrandRounds, Memorial Hospital of Rhode Island,February 2002

• “Developing Curriculum for Milestones in Profes-sional Development: Transitions During MedicalResidency,” Association of Program Directors inInternal Medicine Annual Meeting, Philadelphia, PA,Overall Workshop Director/ Small Group Facilitator,April 2002


• “Evaluation Programs for Combined Medicine-Pediatrics Residencies,” Medicine/Pediatrics ProgramDirectors Association Annual Meeting, Philadelphia,PA, Workshop Co-Leader, April 2002

• “Applying for Fellowships,” American College ofPhysicians-American Society of Internal MedicineAnnual Session, Philadelphia, PA, Invited Panelist,April 2002

• “Morning Report: Twelve Simultaneous Sessions,”Association of Program Directors in InternalMedicine, Philadelphia, PA, Overall WorkshopDirector/ Small Group Facilitator, April 2002

• “Getting Through the Match,” American College ofPhysicians-American Society of Internal MedicineAnnual Session, Philadelphia, PA, Invited Panelist,April 2002

• “Medical Care of the Perioperative Patient,” GrandRounds, Worcester Medical Center, Worcester, MA,Presenter, October 2002

Research and OtherScholarly ActivitiesFaculty Members of Study Sections and AdvisoryCommittees

Robert S. Crausman, M.D.• Principal Investigator, development of a curriculum

in Podogeriatrics, HRSA

Michele G. Cyr, M.D.• Co-PI, Women’s Health Initiative Vanguard Center,

Memorial Hospital of Rhode Island, 2001 – present

• Consultant, AHRQ, “A menopause interactivedecision aid system,” 2002

TEACHING ACTIVITIES

EDUCATION HONORS

Lynn Bowlby, M.D.• Department of Medicine, Attending Teaching Award,

2002

Michele G. Cyr, M.D.• Chairman’s Award for Outstanding Teaching, Brown

Medical School, Department of Medicine, 2002

Joseph A Diaz, M.D.• Profiles in Competence Award – Ability IV “Self-Care,

Self-Awareness and Personal Growth”, Brown MedicalSchool, Providence, RI, May 2003

• Faculty recipient – Arnold P. Gold Humanism in Medi-cine Award, Brown Med. School, Prov., RI, May 2003

• Excellence in Teaching Award, Internal MedicineResidency Program, Memorial Hospital of RI/ BrownMedical School, Pawtucket, RI, June 2003

• Dean’s Teaching Excellence Award, Brown MedicalSchool, 2002

• Member, Mentoring Program for Beginning Faculty,Brown Medical School, 2002

• Innovation in Medical Education, Brown MedicalSchool, Providence, RI, December 2002

Mark J. Fagan, M.D.• Faculty Teaching Award, Brown Medical School, May

2003

• Arnold P. Gold Foundation Award for Humanism inMedicine, Brown Medical School, Class of 2002

• Named “Hooder”, Brown Med. School, Class of 2002

• Senior Citation, Brown Medical School, Class of 2002

• Chairman’s Award for Outstanding Teaching, BrownMedical School, Department of Medicine, 2002

Jennifer Jeremiah, M.D.• Brown Medical School Certificate of appreciation for

ten years of teaching, 2003

• Brown Medical School Excellence in Teaching Award,2001

Carol Landau, PhD• Brown Medical School Distinguished Teacher Award,

2002

• Excellence in Clinical Teaching Award, BrownMedical School, 2002

• Department of Psychiatry & Human BehaviorHonor for Chairing Clinical Appointments,Reappointments and Promotions Committee, 2002

Michael Maher, M.D.• Chairman’s Award for Outstanding Teaching, Brown

Medical School, Department of Medicine, 2003

• Attending Teaching Award, Brown Medical School’sInternal Medicine Residency Program, May 2003

Kelly A. McGarry, M.D.• Faculty Teaching Award, Brown Medical School, May

2003

• Department of Medicine Teaching Award, BrownMedical School, 2002

Benjamin Sapers, M.D.• Dean’s Teaching Excellence Award, Brown Medical

School, 2003

Dominick Tammaro, M.D.• Dean’s Teaching Excellence Award, Brown Medical

School, 2001, 2002

• Faculty Appreciation Award, Brown Medical School,Class of 2001


• Faculty member, Alpha Omega Alpha MedicalSchool Honor Society, elected by student body 2001

• Elected as Faculty Marshall, Brown Medical School,Class of 2002, 2003

Iris L. Tong, M.D.• Dean’s Teaching Excellence Award, Brown Medical

School, 2002


Michele Cyr, M.D.• Program Director, General Internal Medicine

Residency, Rhode Island Hospital

• Ward Attending - Med B (Inpatient Medical Service)

• General Medicine Consult Ward Attending

• Problem-Based Learning, 3rd Year Medical Clerks

• Chief Residents Supervisor as Inpatient Attendings

• Ambulatory Block Seminars for Internal MedicineResidents

• ACGME Core Competency Retreat, ProgramCoordinator & Speaker

• Brown Medical School Graduate Medical EducationCommittee

Jennifer Clarke, M.D.• Second Site Resident Seminars

• Ambulatory-Block Didactics (Health Care for theIncarcerated, Senior Research ProjectDevelopment)

Joseph Diaz, M.D.• Site Director, Brown Medical School Internal

Medicine Clerkship, Memorial Hospital

• Co-coordinator, 3rd year Medical Student InternalMedicine OSCE

• Preceptor, Memorial Hospital Resident Clinic

• Evidence-based medicine lecture series for theMemorial Hospital Residency

• Ambulatory-Block Didactics, Rhode Island Hospital,with Carol Landau, the bilingual interview and careof the underserved

Mark J. Fagan, M.D.• President, National Clerkship Directors in Internal

Medicine (CDIM)

• Medical school curriculum committee and basicclinical skills committee

• Director, Medical Primary Care Unit (MPCU),which serves as a site for about 10 students/year forthe required Longitudinal Clerkship

• Preceptor, Medical Students conducting independentstudy projects


Peter Friedmann, M.D., MPH• Preceptor, Medical Primary Care Unit

• Clerkship or sub-intern involvement: One inpatientward month annually, 3-4 Brown students per weekin outpatient medical clinic.

• Critical Appraisal, Motivational Interviewing, Ambu-latory Morning Report for General Internal Medicineand Categorical Residents on Ambulatory Block


Jennifer Jeremiah, M.D.• Director, community-based education/second site

program

• Primary care and categorical block seminars onclinical teaching

• Co-leader weekly intern conference

• Preceptor for continuity resident

• Medical service attending

Carol Landau, PhD• Direct and implement Behavioral Sciences

Curriculum, General Internal Medicine Residency

• Conduct Professional Development seminars,General Internal Medicine

• Conduct Behavioral Medicine seminars, CategoricalResidency Block

• Conduct Psychological Issues seminars, Medicine-Pediatrics Residency

Michael Maher, M.D.• Preceptor, 3rd year Brown Medical School Internal

Medicine Clerkship

• Ward Attending

• Outpatient Clinical Preceptor

Janet Manes, M.D.• Site Director, for the physical diagnosis class

Kelly A. McGarry, M.D.• Associate Program Director, General Internal

Medicine Residency, Rhode Island Hospital

• Sub-internship Coordinator at RIH

• Dean’s Letters and advisor for undecided students

• Ward Attendings - Med B (Inpatient Medical Service)


• Chief Residents Supervisor as Inpatient Attendings

• Ambulatory Block Seminars for Internal MedicineResidents

• Preceptor, Medical Primary Care Unit

• Ambulatory Morning Report Teaching Sessions forGeneral Internal Medicine Residents




Anne Moulton, M.D.• Ward Attending - Med B (Inpatient Medical Service)


• Co-Director, Department of Medicine ResidentsResearch Program

• Ambulatory Block for Categorical Program:- Alcohol diagnosis and treatment- Evidence based medicine

• Ambulatory Block for Primary Care Residents:- Alcohol diagnosis and treatment- Evidence based medicine- Women’s Health

• Preceptor, Medical Primary Care Unit

• Internal Medicine Second Site Preceptor (categoricaland primary care program residents) at Women’sHealth Associates.

• Third year BMS Internal Medicine Clerkship(Preceptor)

• Third-fourth year rotation in longitudinal care inMedical Primary Care Unit (Preceptor)

• Dean’s Letter writer/adviser for Fourth Yearstudents going into medicine residency

Susan Ramsey, PhD• Motivational Interviewing, Addictive Behaviors

Seminar, Brown Medical School PsychologyInternship Program

• Coordinator, Adult Track Seminar Series, BrownMedical School Psychology Internship Program

Benjamin Sapers, M.D.• Preceptor, 3rd year Brown Medical School Internal

Medicine Clerkship

• Ward Attending, 5 months per year for housestaffand medical students

• Outpatient Clinical Preceptor, full-time 7 monthsper year, part-time 5 months per year

Mark Schleinitz, M.D.• Ward Attending, Providence VA Medical Center

• General Medical Clinic Preceptor, ProvidenceVA Medical Ctr

Michael Stein, M.D.• Clerkship and sub-intern involvement: Two

inpatient ward months annually, 2 Brown studentsper week in outpatient HIV clinic

• Co-Director, Brown Med. School HIV/AIDS elective

• HIV teaching, Motivational Interviewing duringBlock for residents

• 2 internal medicine residents 2nd site preceptorships

Michelle Stozek, M.D.• Precpetor at Rhode Island Hospital and The Miriam

Hospital medical clinics

• Medical Director of the Miriam Medical Clinic

• Second site preceptor for medical resident

• Preceptor for 3rd year medical clerkship course

• Ward attending at Rhode Island Hospital

• Ambulatory morning report preceptor

Dominick Tammaro, M.D.• Associate Program Director, Categorical and

Preliminary Internal Medicine Residency; Co-Director, Combined Program in Medicine/Pediatrics,Rhode Island Hospital

• Interviewing for Residency Programs, Co-Director,workshop for Brown Medical Students

• Small Group Facilitator, Clinical Teaching Seminars,Categorical and General Internal MedicineResidency Program Ambulatory Block Rotations

• Small Group Facilitator, Medicare Billing andDocumentation Seminars, Categorical and GeneralInternal Medicine Residency Program AmbulatoryBlock Rotations



• Service Attending, Med B Inpatient Service, FacultyInstructor

• General Internal Medicine Consultation Attending

• Medical Intern Conference Co-Leader, weeklyconference

• Applying for Fellowships, Medicine Residency NoonConference

• Medical Care of the Perioperative Patient, GrandRounds, Worcester Medical Center

• Morning Report: Fourteen Simultaneous Sessions

Iris L. Tong, M.D.• Physical Diagnosis Course (run by Jack

Schwartzwald, M.D.) for the 2nd year Brown Medicalstudents

• Rational Clinical Exam Course (run by Mark Fagan)for the 3rd year BMS

• Ambulatory Morning Report Teaching Sessions forGeneral Internal Medicine Residents

• Evidence-Based Medicine Teaching Sessions for theCategorical IM Residents

• Problem based-learning sessions for the 3rd yearBMS

• Third year BMS Internal Medicine ClerkshipPreceptor



• Resident Clinic Preceptor

• Resident Second-Site Preceptor


RE

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ams

GRADUATE CAREER CHOICES — 2002

Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM TOTAL PERCENTAGE

Subspecialty Fellow 2 17 7 26 48%

GIM Fellow 0 0%

GIM Private Practice 3 2 2 2 9 17%

GIM Hospital Practice 2 4 6 11%

GIM/Public Health 1 1 2%

Other 3 5 1 3 12 22%

Total 10 28 4 12 54 100%

GRADUATE CAREER CHOICES — 2003

Brown DOM Residencies RIH-GIM RIH-CAT RIH-MP MEM TOTAL PERCENTAGE

Subspecialty Fellow 1 14 7 22 51%

GIM Fellow 1 1 2%

GIM Private Practice 2 4 1 1 8 19%

GIM Hospital Practice 3 2 5 12%

GIM/Public Health 1 1 2%

Other 2 3 1 6 14%

Total 9 24 1 9 43 100%

Chief Medical ResidentsVincent Ho, M.D., Hospitalist, St. Anthony’s Central, Denver, Colorado

William Nicholson, M.D., Cardiology Fellowship, Emory VA Hospital, Atlanta, GA

Michelle A. Stozek, M.D., General Internal Medicine Practice, University Medicine Foundation, Providence, RI

Sarah Tariq, M.D., Academic General Internal Medicine Position, Little Rock, Arkansas

Kathy Tuohy, M.D., Nephrology Fellowship, Beth Israel Hospital, Boston, MA

General Internal Medicine ResidentsAmy S. Gottlieb, M.D., Private Practice

Douglas R. Gronda, M.D., Practice in MassachusettsSharrah E. Jenkins, M.D., Group Practice, Wendover Medical Center, Greensboro, NC

James Y. Kim, M.D., Locum Tenens, Ohio

Karen Kim, M.D., Hospital Practice, Community Medical Center, West-Torns River, NJ

Troy M. Martin, M.D., Infectious Disease Fellowship, Brown Medical School-Rhode Island Hospital, Providence, RI

Daniel A. Miller, M.D., Faulkner Hospital, West Roxbury, MA

Virginia R. Smith, M.D., Chief Medical Resident, Brown Medical School, Providence, RICharles W. Tate, M.D., Chief Medical Resident, Brown Medical School, Providence, RI

Rollin M. Wright, M.D., Geriatrics Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI

Categorical Internal Medicine ResidentsCurt G. Beckwith, M.D., Chief Medical Resident, Internal Med. Resid. Programs, Brown Medical School, Providence, RI

Michael A Capicotto, M.D., Hospitalist (02-03), Coastal Medical, Prov., RI; ’03-Nephr. Fellow., Brown Med. Sch., Prov., RI

Gerardo P. Carino, M.D., Pulmonary Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI

Youngsoo Cho, M.D., Hospital Practice, Charlton Memorial Hospital, Fall River, MA

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITALG R A D U A T E C A R E E R P L A N S 2 0 0 2


Chief Medical Residents

Virginia Barrow, M.D., Private Practice-Anchor Medical Associates, Lincoln, RI

Curt Beckwith, M.D., Infectious Disease Fellowship, Brown Medical SchoolProvidence, RI

Jennifer Roh, M.D., Hospital Practice: RI Hospital, Div. of Gen. Internal Medicine, Brown Medical School, Providence, RI

Charles Tate, M.D., Cardiology Fellowship-Univ. of Colorado, Denver, Colorado

Andrew Stone, M.D., Pulmonary Diseases & Critical Care Medicine Fellowship, Brown Medical School, Providence, RI

General Internal Medicine Primary Care Residency

General Internal Medicine ResidentsAmy Boyer, M.D., Hospitalist, Kent County Hospital, Warwick, Rhode Island

Irene Dejak, M.D., General Medical Practice at Univ.-based practice, University Hospitals of Cleveland, Case WesternReserve University, Cleveland, OHSharon Flynn, M.D., General Medical Practice Oregon Medical Group, Eugene, Oregon

Agnieszka Heith, M.D., General Medical, Lahey ClinicBurlington, MA

Amy Huang, M.D., Private Practice, Concore Medical GroupNew York, New York

Rebekah Kaplowitz, M.D., General Internal Medicine Fellowship, Harvard Medical SchoolBoston, MA

Aaron Maxwell, M.D., Chief Medical Resident, Internal Medicine Residency ProgramsBron Medical SchoolProvidence, RI

Kristin Poshkus, M.D., II. Chief Medical Resident, Internal Med. Residency Programs Brown Medical School, Prov., RIDareen Siri, M.D., Allergy/Immunology Fellowship, Univ. of South Florida-All Children’s HospitalSt. Petersburg, Florida

Jonathan Cohen, M.D., Infectious Disease Research Training Grant, The Miriam Hospital, Providence, RI

Henry L. Danis, M.D., Gastroenterology Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RIMelissa A. Diianni, M.D., Internal Medicine Practice (2002-03), Coastal Medical, Providence, RI, (2003) Plans for Fellowship

David S. Fefferman, M.D., Gastroenterology Fellowship, Beth Israel/Deaconess Hospital, Boston, MA

Paari Gopalakrishnan, M.D., Hospitalist Position, The Miriam Hospital, Providence, RI

Mark C. Heckel, M.D., Cardiology Fellowship, Brown Medical School, Providence, RI

Meera Khedkar, M.D., Asthma Research, Stony Brook, Long Island, NY

Anna M. Kho, M.D., Academic Position, Grady Memorial Hospital, Emory University, Atlanta, GAEugene H. Kim, M.D., Nephrology Fellowship, Washington Hospital Center, Washington, DC

Sue Kim, M.D., Fellowship, Stanford University, Stanford California, Stanford, California

Aslam Lateef, M.D., Allergy & Immunology Fellowship, Thomas Jefferson Univ., Al Dupont Hosp. for Children, Phil., PA

Waymon C. Lattimore, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RI

Charles J. Lee, M.D., Pulmonary/Critical Care Fellowship, Brown Medical School, Rhode Island Hospital, Providence, RI

Jonah M. Licht, M.D., Nephrology Fellowship, Cornell Medical School, NY, NYDavid J. Liss, M.D., Pulmonary-Critical Care Fellowship, Yale University School of Medicine, New Haven, CT

Rocco Martino, M.D., Sports Medicine Fellowship, Jersey Shore Hospital, Neptune, NJ

Linda B. McMorrow, M.D., Hematology/Oncology Fellowship, Brown Medical School, Rhode Island Hosp., Providence, RI

Michael J. O’Brien, M.D., Group Practice, Emory medical Associates, Attleboro, MA

Eric B. Radler, M.D., Research Position in Cardiology, Rhode Island Hospital, Providence, RI

Ramya Ramakrishnan, M.D., Locum Tenans (2002-03); Nephrology Fellowship, New York University, NY, NYJennifer S. Roh, M.D., Chief Medical Resident, Internal Medicine Resid. Programs, Brown Medical School, Providence, RI

Anthony M. Santilli, M.D., Hosp. Position, Albany, NY

Peter F. Sholler, M.D., Internal Medicine Group Practice, Anchor Medical Associates, Providence, RI

Andrew C. Stone, M.D., Chief Medical Resident, Internal Medicine Resid. Programs, Brown Medical School, Prov., RI

Medicine-Pediatrics ResidentsDeborah J. Ganem, M.D., Med/Peds Practice, Nashua, NH

Suzanne McLaughlin, M.D., RWJ Clinical Scholars Fellowship, Johns Hopkins Univ., Baltimore, M.D..

Michael K. Mraz, M.D., Indian Health Service, Norton Sound Health Corp., Nome, AlaskaIvelisse A. Verrico, M.D., Academic Med/Peds Practice, St. Louis University, St. Louis, MO

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITALG R A D U A T E C A R E E R P L A N S 2 0 0 3


Categorical Internal Medicine ResidentsArielle Adrien-Jean, M.D., Hospital Practice (Public Health), Lemuel Shattuck HospitalJamaica Plain, MA

Letitia Anderson, M.D., 2003-Primary CareGiven Essex Int. Med, Vermont 2004-Cardiology Fellow., Univ. of Vermont

John Barnett, M.D., Medicine/Hematology/Oncology Fellowship, Brown Medical SchoolProvidence, RIDavid Benton, M.D., III. Chief Medical Resident, Internal Medicine Residency Programs, Brown Medical School, Prov., RI;2004, Hematology-Oncology Fellowship, Brown Medical School

Eric Bouchard, M.D., General Medical Practice, North Ridge Medical Center, Ft. Lauderdale, FL

Kent Chen, M.D., Cardiovascular Disease Fellowship, University of Washington Program, Seattle, WA

Michael CohenUram, M.D., Internal Medicine Impatient Services Hospitalist, Rhode Island Hospital, Providence, RI

Robert Denshaw, M.D., 2003 Internal Medicine Impatient Services Hospitalist; 2004 Nephrology Fellowship, University ofPittsburgh, Pittsburgh, PA

Patrick Hyatt, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RINikhil Iyengar, M.D., 2003 Hospitalist PositionCharlton Hospital,New Bedford, MA

Miroslawa Jablonski-Cohen, M.D., IV. Chief Medical Resident, Internal Med. Resid. Prog., Brown Medical School, Prov., RI

Charles Katopes, M.D., Hepatology Fellowship, Thomas Jefferson Medical College, Thomas Jefferson Hospital, Phil., PA;2004, Gastroenterology Fellowship, University of Wisconsin

Jonathan Koff, M.D., Pulmonary Diseases & Critical Care Medicine Fellowship, University of California, San Francisco, CA

Christina Le, M.D., Hosp.-Based Spec., Oakland-Kaiser Med. Ctr.-HBS 2004 Infec. Dis. Fel., Univ. of Cal., Davis, Sac., CA

Tsao-Yu Liang, M.D., Endocrinology & Metabolism Fellowship, Brown Medical School Rhode Island Hospital, Prov., RICarol Mallette, M.D., Gastroenterology Fellowship, Brown Medical School, Providence, RI

Michael McKenna, M.D., 2003 Pulmonary Diseases & Critical Care Med. Fellowship, Brown Medical School 2004 Heme/Onc Fellowship, Brown Medical School, Providence, RI

Adam Niedelman, M.D., Cardiovascular Diseases Fellowship, Brown Medical School, Providence, RI

Irene Orzano, M.D., 2003 Hospitalist Position, VA Med. Ctr. 2004 Rheum. Fellow., Roger Williams Med. Ctr., Prov., RI

Ursula Reusch, M.D., Hematology-Oncology Fellowship, Boston University, Boston, MAGretchen Schueckler, M.D., General Medicine Practice - Medicine Associates, Providence, RI

Linda Shipton, M.D., 2003 Group Practice-Lowell Community Health Center Lowell MA 2004 Infectious DiseaseFellowship, Beth Israel Deaconess Medical Center, Boston, MA

Jean Siddall-Bensson, M.D., Group Practice-Sturdy Memorial Hospital, Attleboro, MA

John Snyder, M.D., V. Chief Medical Resident Internal Medicine Residency Programs, Brown Medical School, Prov., RI

Sarah Taylor, M.D., Primary Care Practice-Medical Specialists, Chelmsford, MA

Binh Truong, M.D., Group Practice - Associates in Internal Medicine (A Lee Physicians Group), Fort Myers, Florida

Medicine-Pediatrics ResidentsMark Niehaus, M.D., Group Practice: General Internal Medicine and PediatricsPalmyra Family and Internal Medicine-

Hospital, Palmyra, Virginia

Stephanie Knabe, M.D., Medicine/Pediatrics Hospital-Based Faculty, Children’s Hospital of Philadelphia, University ofPennsylvania


Internal Medicine ResidentsHani Abdallah, M.D., Fellowship in Clinical Epidemiology at Mass GeneralHospital

Ahmad Al-Mubaslat, M.D., Chief Resident at Forum Health, North Side Medical Center in Youngstown, Ohio EndocrineFellowship at Phoenix VA Medical Center in Phoenix, AZ

Ahmad Al-Raqqad, M.D., Co-chief Resident at Memorial Hospital through 12/31/02

Bharti Chauhan, M.D., Hematology/Oncology Fellowship, Brown Medical School

Kala Davis, M.D., Pulmonary Fellowship at Stanford

Hussam Hamdalla, M.D., Cardiology Fellowship at the University of Kentucky in Lexington, KY.Maen Hussein, M.D., Hematology/Oncology Fellowship at St. Louis University in St. Louis, MO.

Rosario Manalo, M.D., Infectious Disease Fellowship, Brown Medical School

J. Anthony Murat, M.D., Primary Care group practice in Sarisota, Florida.

Brian Pickett, M.D., Primary Care Private Practice in Cranston, RI

Randy Sid, M.D., Chief Resident, Memorial Hospital

Sowmya Suryanarayanan, M.D., Endocrinology Fellowship at University of Michigan

Categorical Internal Medicine ResidentsSyed Quadri, Critical Care Fellowship, Brown Univ. Medical School

Marwan Mustaklem, Primary Care medical practice Armistice Blvd., Pawtucket, RI

Kanan Maniar, Physician for the Fashion Institute of New York; Rheumatology Fellowship in 2004

Levis Guzman, Critical Care Fellowship, Brown University

Nik Karanth, Gastroenterology Fellowship, Albany Medical School

Victor Kwok, Geriatrics Fellowship, University of HawaiiLove Dalal, Co-chief Resident, Primary Care Internal Medicine Residency, MHRI

Ralph Santoro, Pulmonary Fellowship, Univ. of Massachusetts

MEMORIAL HOSPITAL OF RHODE ISLANDG R A D U A T E C A R E E R P L A N S 2 0 0 2 - 2 0 0 3

Residency Graduate Career Choices

Academic Years 2001 and 2002

46%

1%18%

13%

2%

20%

Subspecialty

Fellow

GIM Fellow

GIM Private

Practice

GIM Hospital

Practice

GIM/Public Health

Other

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITAL


PGY-1 General Internal MedicineSrividya Anandan, M.D. Tufts University

Julie Bard, M.D. University of Vermont

Thomas Doyle, M.D. Brown Medical School

Lakshmi Gopal, M.D. University of Florida

Luke Hansen, M.D. Loyola University

Sumana Kesh, M.D. Drexel University

Mara Linscott, M.D. SUNY Buffalo

Alisa Merolli, M.D. Drexel University

Nora Taylor, M.D. Eastern Virginia Med. Sch.

Zolfa Valiani-Merchant, M.D. University of Texas

PGY-2 General Internal MedicineLaurel Bliss, M.D. Tulane Univ.

Elisa Freeman, M.D. Univ. of Massachusetts

Allison Friedenberg, M.D. Univ. of Wisconsin

Tara Lagu, M.D. Yale Univ.

Catherine Malone, M.D. Univ. of Rochester

Donnah Matthews, M.D. Geo. Washington Univ.

Bismruta Misra, M.D. Howard Univ.

Sheri Qi, M.D. Univ. of Pennsylvania

Megan Tamburini, M.D. SUNY Upstate

Traci Tupper, M.D. Temple Univ.

PGY-3 General Internal MedicineAnikke M. Cengel, M.D. Tulane Univ.

Kathryn DeAnzeris, M.D. Univ. of Massachusetts

Michele S. Goh, M.D. Univ. of Alberta

Mary H. Hohenhaus, M.D. Univ. of Pittsburgh

Lori G. Lieberman, M.D. MCP Hahnemann

Mercedes Murphy, M.D. Univ. of Miami

Philip C. Russell, M.D. MCP Hahnemann

Elizabeth A. Tillman, M.D. MCP Hahnemann

Lorna B. Weinheimer, M.D. MCP Hahneman

Joseph M. Wiener, M.D. Mt. Sinai

Edward H. Wu, M.D. New York Univ.

RHODE ISLAND HOSPITAL AND THE MIRIAM HOSPITALG E N E R A L I N T E R N A L M E D I C I N E – C U R R E N T R E S I D E N T S 2 0 0 3 - 2 0 0 4

PGY-1 CategoricalGeorge Bayliss, M.D. Brown Medical School

Mathew Buchalter, M.D. NY Medical College

Megan Callahan, M.D. Tufts University

Bradley Collins, M.D. Penn State

Susan Eckert, M.D. Albany Medical College

Robert El-Kareh, M.D. Temple University

Anthony Febles, M.D.* Dartmouth Medical School

Scott Ferreira, M.D. Tulane University

Andrew Freeman, M.D. SUNY Buffalo

Mita Gupta, M.D. New York Medical College

Rebecca Hirsh, M.D. Brown Medical School

Joseph Hou, M.D.* Brown Medical School

Christopher Hurt, M.D. University of Florida

Lisa Kallenbach, M.D. Brown Medical School

Corey Karlin, M.D. SUNY Stony Brook

Olga Lurye, M.D. University of Maryland

Douglas Martin, M.D. University of Rochester

Mitchell McClure, M.D. University of Connecticut

Erin McGeeney, M.D. University of Missouri

Anil Nabha, M.D. Temple University

Eric Newton, M.D. University of Vermont

Brian Phillips, M.D. UMDNJ - Robert Wood

Johnson

Angela Plette, M.D. University of Massachusetts

Jessica Salt, M.D. Virginia Commonwealth U.

Gabriel Sica, M.D. Mayo Medical School

Yon Sung, M.D. University of Pittsburgh

Corey Ventetuolo, M.D. Tufts University

Michael Via, M.D. NY Medical School

Paige Wickner, M.D. Dartmouth Medical School

James Yess, M.D. Loyola University

Patricia Zappa, M.D. Wayne State University

PGY-2 CategoricalKhaled Abdel-Kader, M.D. UMDNJ-RWJ

Renee Amori, M.D. MCP Hahnemann

Elliott Anderson, M.D. Albany Medical College

Christina Baik, M.D. Univ. of Rochester

John Brennan, M.D. Tufts University

Alison Comite, M.D. New York Medical Center

Beth Fisher, M.D. Jefferson Medical College

Soniya Gandhi, M.D. Jefferson Medical College

Ellen Hartmann, M.D. Jefferson Medical College

Robert Holland, M.D. Pennsylvania State

Sujani Kakumanu MD Pennsylvania State

Christine Kerr, M.D. Univ. of Buffalo

Emmy Mahoney, M.D. Brown Medical School

John Mascarenhas, M.D. New York Medical College

C A T E G O R I C A L I N T E R N A L M E D I C I N E – C U R R E N T R E S I D E N T S 2 0 0 3 - 2 0 0 4


PGY-2 Categorical (continued)

Tarun Mathur, M.D. Jefferson Medical College

Jeffrey Mazer, M.D. Tufts Univ.

Cara McLaughlin, M.D. Johns Hopkins Univ.

Cathryn McNamara, M.D. Univ. of Rochester

Stephan Muhlebach, M.D. UConn

Richard Regnante, M.D. MCP Hahnemann

Anna Rudnicki, M.D. Univ. of Massachusetts

Daniel Selo, M.D. Indiana Univ.

Anisa Shaker, M.D. Medical College of Wis.

Shivani Sood, M.D. SUNY Downstate

Sejal Thaker, M.D. Tufts Univ.

Raymond Tsao, M.D. UMDNJ-RWJ

Barton Wise, M.D. Boston Univ.

PGY-3 CategoricalKamel Addo, M.D. Dartmouth & Brown

Trimble S. Augur, M.D. Univ. of Vermont

Carrie M. Burns, M.D. UMDNJ-RWJ

Venu Channamsetty, M.D. Albany Medical College

Amy K. Chi, M.D. Johns Hopkins

Sooyun Chun, M.D. Cornell Univ.

Amy Churchill, M.D. Uconn

C A T E G O R I C A L I N T E R N A L M E D I C I N E – C U R R E N T R E S I D E N T S 2 0 0 3 - 2 0 0 4

Bejamin J. Conway, M.D. Univ. of Massachusetts

Sarah Leleiko Cutrona, M.D. Columbia Univ.

Gregg S. Gagliardi, M.D. UMDNJ-RWJ

Michael W. Ham, M.D. Univ. of Miami

Thomas Isaac, M.D. Jefferson Medical College

Amit A. Johnsingh, M.D. SUNY Brooklyn

Robert J. Ludwig, M.D. NY Medical College

Paul B. Martin, M.D. Brown Medical School

Jennifer D. Moodie, M.D. UMDNJ-RWJ

Elvis R. Pagan, M.D. Univ. of North Carolina

Reina D. Pai, M.D. Albany Medical College

Michael A. Papper, M.D. Mt. Sinai

Randall S. Pellish, M.D. Univ. of Massachusetts

Michael B. Polsky, M.D. Univ. of Florida

Tara Rajan, M.D. UMDNJ-RWJ

Usman C. Ramzan, M.D. Boston Univ.

Miguel A. Rodriguez, M.D. Univ. of Massachusetts

Matthew J. Solitro, M.D. Univ. of Pittsburgh

Katherine A. Thornton, M.D. Mt Sinai

Ana C. Tuya, M.D. Geo. Washington Univ.

Sabrina M. Witherby, M.D. Univ. of Massachusetts

PGY-1 PreliminaryCraig Burkhard, M.D. Medical College of OhioKaren Chan, M.D. SUNY BuffaloDavid DeVries, M.D. University of N CarolinaAmanda Diamond, M.D. University of N DakotaBruce Fuller, M.D. Dartmouth Medical CollegeKarin Johnson, M.D. University of ChicagoPrabhav Kenkre, M.D. University of New MexicoJason McBean, M.D. Brown Medical SchoolDavid Morgenroth, M.D. SUNY DownstateDavid Poch, M.D. Brown Medical SchoolErica Szabados, M.D. George Washington Univ.

PGY-1Scott Cohen, M.D. Saint Louis UniversityMichael Connor, M.D. Medical College of GeorgiaMeghan Eckstein, M.D. Georgetown UniversityJessica Fairley, M.D. Georgetown UniversityTraci Wolbrink, M.D. Michigan State UniversityPGY-2Erica Blood, M.D. Geo Washington Univ.Chadwick Johr, M.D. Pennsylvania State Univ.Kristin Lehr, M.D. Albany Medical CollegePGY-3Jocelyn P. Beattie, M.D. VCU/MCVJoanna D. Bell, M.D. MCP HahnemannLoida Bonney, M.D. SUNY BrooklynAnitha S. John, M.D. MCP HahnemannPGY-4Blayne H. Cutler, M.D. Univ. of PennsylvaniaIsaac P. Dapkins, M.D. Mt. SinaiJeffrey Merkle, M.D. UMDNJ-RWJJoel T. Park, M.D. Brown Medical School

P R E L I M I N A R Y I N T E R N A L M E D I C I N EC U R R E N T R E S I D E N T S – 2 0 0 3 - 2 0 0 4

M E D I C I N E - P E D I A T R I C SC U R R E N T R E S I D E N T S – 2 0 0 3 - 2 0 0 4



PGY-1

Christina Anderlind, M.D. Humboldt-Universitat Berlin, Germany

Anjali Basil, M.D. Indira Gandhi Medical College, Shimla India

Manuel Cunanan, M.D. 5th Pathway Prog.–N.Y. Med. Coll./Universidad Autonoma de Guadalajara, Mexico

Mina Guico, M.D. Univ. of Santo Tomas Espana, Manila, Philippines

Jose Felix, M.D. Huerta National Autonomous University, Mexico

Majd Jwied, M.D. University of Jordan in Amman, Jordan

Mutaz Labib, M.D. Dokuz Eylul University, Turkey

Raissa Paredes, M.D. University of The East, Philippines

Eleni Patrozou, M.D. University of Athens, Greece

Kevin Price, M.D. Philadelphia College of Osteopathic Medicine

Richard Ruffin, M.D. The University of the West Indies, Jamaica

PGY-2

Ahmad Abu-Halimah, M.D. Ain Shams University, Egypt

Joanne Castro, M.D. New York Medical College, USA

Jonathan Costa, D.O. Un. N. Texas Health Science Center, College of Osteopathic Medicine, USA

Michelle Costa, D.O. Un. N. Texas Health Science Center, College of Osteopathic Medicine, USA

Geraldina Kica, D.O. New England College of Osteopathic Medicine, USA

Hemchand Ramberan, M.D. University of Guyana, South America

Rameshwar Reddy, M.D. Saba Univ., Netherlands, Antilles

Kurush Setna, M.D. Dow Medical College, Pakistan

Sally Stipho, M.D. University of Nottingham, England

PGY-3

Irfan Ahmad, M.D. Allama Iqbal Medical College, Pakistan

Rahul Ahuja, M.D. Ross University, Dominica

Kristine Cunniff, D.O. New England College of Osteopathic Medicine, USA

Teresa Daniele, M.D. Ross University, Dominica

Michael DiBari, M.D. Saba University, Netherlands, Antilles

Chuck Huang, M.D. St. Georges University, Grenada

Mridula Menon, M.D. Med. College Kottayan, India

Ami Muehlberg, D.O. New England College of Osteopathic Medicine, USA

Iole Ribizzi-Akhtar, M.D. University Di Genova, Italy

Chief Resident

Jodi Sebastian, M.D. Loyola University Stritch School of Medicine

Love Dalal, M.D. (Co-Chief) Gujarat University, Ahmedabad, India

C U R R E N T R E S I D E N T S – 2 0 0 3 - 2 0 0 4



Michele Cyr, M.D.• McGarry KM, Clarke JG, Cyr MG, Landau C. Evaluating

a Lesbian and Gay Health Care Curriculum. Teachingand Learning in Medicine: An International Journal,2002; 14(4): 244-248.

• Tammaro D, McGarry KM, Cyr MG. The Role of thePrimary Care Physician in the Care of Women with HipFractures. Clinical Journal of Women’s Health, 2002, 2(2):65-78.

• Chlebowski RT, Hendrix S, Langer RD, Stefanick ML,Gass M, Lane D, Rodabough RJ, Gilligan MA, Cyr MG,Thomson CA, Khandekar J, Petrovich H, McTiernan A.Influence of Estrogen Plus Progestin on Breast Cancerand Mammography. JAMA, 2003; 289(24): 3243-3253.

• Cyr MG. Postmenopausal Hormone Therapy in theAftermath of the WHI: What Patients Need to Know.Postgraduate Medicine 2003; 113(3): 15-20.

• Landau CL, Cyr MG. The New Truth About Menopause.In press. St. Martin’s Press, 2003.

Mark Fagan, M.D.• Elnicki D M, Curry RH, Fagan MJ, Friedman E, et al.

Medical Students’ Perspectives on and Responses toAbuse During the Internal Medicine Clerkship. Teachingand Learning in Medicine; An International Journal 2002,13(2):92-97.

• Sidlow R, Mechaber AJ, Reddy S, Fagan MJ, Marantz PR.The Internal Medicine Subinternship. A CurriculumNeeds Assessment. i 2002, vol. 17;7:561-564.

• Griffith R, Fagan MJ, Obbard L, O’Connor C. Can anEvidence-Based Approach Resuscitate Medical Students’Skill in Physical Diagnosis? Accepted for publicationJGIM, March, 2003

• Fagan, MJ, Diaz J. Impact of Interpretation Methods onClinic Visit Length. Accepted for publication, JGIM,March 2003.

• Roth CS, Fagan MJ, Griffith JM, Nelson D, Zhao Yanli.Evaluation of a Worksheet to Structure Teaching andLearning Outpatient Internal Medicine. Medical Teacher.2003 25;(3):311-316

Peter Friedmann, M.D., MPH• Friedmann PD, McCullough DM, Saitz R. Screening and

intervention for illicit drug abuse: A national survey ofprimary care physicians and psychiatrists.Archives of Internal Medicine 2001; 161(2): 248-251.

• Friedmann PD, Lemon SC, Stein MD, Etheridge RM,D’Aunno TA. Linkage to medical services in the DrugAbuse Treatment Outcome Study (DATOS). MedicalCare 2001; 39:284-295.

• Friedmann PD, Lemon S, Anderson BJ, Stein MD.Predictors of follow-up health status in the Drug AbuseTreatment Outcome Study (DATOS). i 2003; 69(3): 243-251.

• Friedmann PD, Zhang Z, Hendrickson J, Stein MD,Gerstein DR. The effect of primary medical care onaddiction and medical severity in substance abusetreatment programs. I 2003; 18:1-8.

• Friedmann PD, Lemon S, Stein MD, D’Aunno TA.Accessibility of addiction treatment: results from anational survey of outpatient substance abuse treatmentorganizations. Health Services Research 2003; 38(3): 887-903.

Kelly McGarry, M.D.• McGarry KA, Cyr MG. Prevention of bone loss and frac-

tures in postmenopausal osteoporosis. ClinicalGeriatrics, 2001; 9(9):47-56.

• McGarry KA, Stein MD, Clarke JG, Friedmann P.Utilization of preventive health services by HIV-seronegative injection drug users. Journal of AddictiveDiseases, 2002; 21(2):93-102.

• Cyr MG, McGarry KA. Alcohol use disorders in women:Screening methods and approaches to treatment.Postgraduate Medicine, 2002; 112(6):31-47.

• McGarry KA, Clarke JG, Cyr MG, Landau C. Evaluatinga lesbian and gay health care curriculum. Teaching andLearning in Medicine, 2002; 14(4):244-248.

• McGarry KA, Tammaro D, Cyr MG. Diagnosing andmanaging postmenopausal osteoporosis: Opportunitiesfor fracture prevention. Comprehensive Therapy, 2003 (inpress)

GENERAL INTERNAL MEDICINE FELLOWSHIP PROGRAMDeparting Fellows

Javid Calcatti, M.D., Government Medical College, (University of Kashmir), Srinagar, India. Fellow inSyncope, Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH

John Lopez, M.D., Visiting Instructor of Medicine at the University of Pittsburgh Medical Center

Fellows

Christine M. Duffy, M.D., Post-Doctoral Fellow, Brown Medical School, General Int. Med. Residency Program


Roy Poses, M.D.• Stone VE, Mansourati FF, Poses RM, Mayer KH. Relation

of physician specialty and HIV/AIDS experience tochoice of guideline recommended antiretroviral therapy.J Gen Intern Med, 2001; 16(6):360-368.

• Smith WR, Poses RM, McClish DK, Huber EC, ClemoFLW, Schmitt BP et al. Prognostic judgments and triagedecisions for patients with acute congestive heart failure.Chest 2002; 121:1610-1617.

• Poses RM, Krueger J, Sloman S, Elstein A. Physicians’judgments of survival after medical management andmortality risk reduction due to revascularizationprocedures for patients with coronary artery disease.Chest 2002; 122:122-133.

• Lawrence VA, Hilsenbeck SG, Noveck H, Poses RM,Carson JL. Medical complications and outcomes afterhip fracture repair. Arch Intern Med 2002; 162: 2053-2057.

• Poses RM. A cautionary tale: The dysfunction ofAmerican health care. Eur J Int Med 2003; 14: 123-130.

Susan Ramsey, PhD• Brown RA, Kahler CW, Niaura R, Abrams DB, Sales SD,

Ramsey SE, Goldstein MG, Burgess ES, Miller IW.Cognitive-Behavioral Treatment for Depression inSmoking Cessation. Journal of Consulting and ClinicalPsychology 2001; 69(3): 471-480.

• Ramsey SE, Brown RA, Stuart GL, Burgess ES, Miller IW.Cognitive Variables in Alcoholics with ElevatedDepressive Symptoms: Changes and Predictive Utility asa Function of Treatment Modality. Substance Abuse2002; 23(3): 171-182.

• Ramsey SE, Brown RA, Strong DR, & Sales S. CigaretteSmoking among Adolescent Psychiatric Inpatients:Prevalence and Correlates. Annals of Clinical Psychiatry2002; 14(3): 149-153.

• Kahler CW, Ramsey SE, Read JP, Brown RA. Substance-Induced and Independent Major Depressive Disorder inTreatment-Seeking Alcoholics: Associations withDysfunctional Attitudes and Coping. Journal of Studieson Alcohol 2002; 63: 363-371.

• Kahler CW, Brown RA, Ramsey SE, Niaura R, AbramsDB, Goldstein MG, Mueller TI, Miller IW. NegativeMood, Depressive Symptoms, and Major Depressionafter Smoking Cessation Treatment in Smokers with aHistory of Major Depressive Disorder. Journal ofAbnormal Psychology 2002; 111(4): 670-675.

Michael Stein, M.D.• Stein MD, Sobota M. Injection drug users: hospital care

and charges. Drug and Alcohol Dependence 2001; 64:117-120.

• Stein MD, Friedmann PD. Generalist Physicians andAddiction Care–From Turfing to Sharing Turf. Journal ofthe American Medical Association 2001; 286(14):1764-1765.

• Stein MD, Anderson B, Charuvastra A, Maksad J,Friedmann PD. A Brief Intervention for HazardousDrinkers in a Needle Exchange Program. Journal ofSubstance Abuse Treatment 2002; 22:23-31.

• Brienza RS, Stein MD. Alcohol Use Disorders in PrimaryCare: Do Gender Specific Differences Exist? Journal ofGeneral Internal Medicine 2002; 17:387-397.

• Stein MD, Charuvastra A, Maksad J, Anderson BJ. ARandomized Trial of a Brief Alcohol Intervention forNeedle Exchangers. Addiction 2002; 97:691-700.

Dominick Tammaro, M.D.• Wachtel T, Wilcox V, Moulton A, Tammaro D, Stein M.

Physicians’ Utilization of Health Care. Journal of GeneralInternal Medicine. 1995; 10(5):261-5.

• Stein M, Hanson S, Tammaro D, Hanna H, Most AS.Economic effects of community versus hospital-basedfaculty pneumonia care. Journal of General InternalMedicine. 1998; 12(11):774-7.

• Tammaro D, McGarry KM, Cyr MG. The Role of thePrimary Care Physician in the Care of Women with HipFractures. Clinical Journal of Women’s Health. 2002;2(2):65-78

• Christopher K, Tammaro D, Wing EJ. Early ScurvyComplicating Anorexia Nervosa. Southern MedicalJournal. 2002; 95(9):1056-6.

• McGarry K, Cyr M, Tammaro D. Diagnosing andManaging Post-Menopausal Osteoporosis: Opportu-nities for Fracture Prevention. Comprehensive Therapy.Submitted/Accepted 2002.


CLINICAL RESEARCH

Jennifer Clarke, M.D.,

• Women Leaving Prison: Two Models of FamilyPlanning Service Delivery, Department of Health andHuman Services

• Women in Prison: Decreasing Unplanned Pregnan-cies & STDs, NIH/National Institute for Child Healthand Development

Mark Fagan, M.D.

• Primary Care Anxiety Project, Brown University

• The Principal Activity Counseling Trial in PrimaryCare, Boston University

• Communication Skills for Male Cancer Screening,Brown University

Peter Friedmann, M.D.

• Linkages to Primary Care in Drug Abuse TreatmentPrograms, NIH/National Institute on Drug Abuse

Primary Care Relapse After Addiction Treatment,Robert Wood Johnson Foundation

• Trazodone for Sleep Disturbance in Early AlcoholRecovery, NIH/National Institute on Alcohol Abuseand Alcoholism

• Linkage to Health Services in Drug Abuse Treatment,NIH/National Institute on Drug Abuse

• Continuity of Care for Drug-Addicted Offenders inRI, NIH/National Institute on Drug Abuse

Aruna Gogineni, Ph.D.

• Brief Alcohol Intervention Using Social NetworkSupport, NIH/National Institute on Alcohol Abuseand Alcoholism

• Effect of Alcoholic Parental Gender on FemaleAlcoholism, NIH/National Institute of Alcohol Abuseand Alcoholism

Kelly McGarry, M.D.

• A Survey of Lesbian Health Curricula for U.S. InternalMedicine Residents, The Lesbian Health Fund

Anne Moulton, M.D.

• Faculty Development in General Internal Medicine,Bureau of Health Professions, HRSA

Cynthia Rosengard, Ph.D.

• Partner-Specific Factors in Adolescent SexualBehavior, NIH/National Institute of Mental Health

Mark Schleinitz, M.D.

• Birtch Scholarship Award, NIH/Women and InfantsHospital

Michael Stein, M.D.

• A Multi, Double-Blind, Randomized Pilot Study toCompare the Safety and Activity, Miriam Hospital

• A Ramdomized Phase IIIB Comparison Study toEvaluate Saquinavir Soft Gel Capsule (SGC) TIDRegimen in Combination with Two NRTIs VersusSaquinavir Soft Gel Capsule., Roger Williams

• Grepafloxacin vs Azithromycin in the Treatment ofAcute Bronchitis for HIV Infected Persons, Glaxo

• A Phase IV, Open Label Study to Assess the Safety andTolerability of Abacavir in HIV-1 Infected Individualsand to Investigate the Effect of Base line Genotype,Glaxo

• HIV Prevention for High Risk Substance AbuseIdentified at Rhode Island Hospital and Engagementand Assistance Approach, Marathon

• Smoking Cessation Among Methadone-MaintainedPatients, NIH/National Cancer Institute

• Motivation and Patch Treatment for HIV-PositiveSmokers, Miriam Hospital

• Antidepressant Treatment to Reduce HIV Risk AmongIDUs, NIH/National Institute of Mental Health

• Prospective, Uncontrolled, Open-Label MulticenterClinical Trial Evaluating the Efficacy and Safety, BayerCorporation

• Midcareer Investigator Award in Substance Abuse -Research, NIH/National Institue on Drug Abuse

• Physician Syringe Prescription Pilot, The MiriamHosp.

• Adult Therapeutic Clinical Trials Program for HIV/AIDS, The Miriam Hospital

• A Trial to Reduce Hepatitis C Among Injection DrugUsers, NIH/National Institute on Drug Abuse

• Adapting to HIV Disease: Family Intervention, NIH/National Institute of Mental Health

• Maintaining HIV Risk Reduction Among NeedleExchangers, NIH/National Institute of Mental Health

Dominick Tammaro, M.D.

• Residency Training in General Internal Medicine/Pediatrics, Bureau of Health Professions, HRSA

• Rhode Island Hospital Medicine/Pediatrics Residency,Health Resources & Services Administration


Total Clinical Research Expenses Academic Year 2002 $2,443,573 $816,716 $3,260,289

Academic Year 2003 $2,648,209 $941,338 $3,589,547

G E R I AT R I C S

Richard W. Besdine, M.D., Interim Dean, Brown

Medical School, David S. Greer, M.D. Professor of

Medicine; Director, Division of Geriatrics

Overview

The past two years of the Division under Dr.Besdine’s leadership have been dynamic; althoughclinical and educational growth begun in 2000 havecontinued, major changes have occurred. Divisionfaculty since Dr. Besdine’s arrival have grown from twofull-time geriatricians in 2000 to 6, with therecruitment of Drs. Besdine, Burrill, Nanda andMcNicoll (FT) and Dr. Teno (part time). Oneadditional Nurse Practitioner, Robin Ferreira, was alsorecruited. In June of 2002, Dr. Burrill left for a newnon-clinical position, and Nurse Ferreira left a fewmonths later. In May of 2002, it was announced thatDr. Besdine had been appointed Interim Dean of

GERIATRICSMedicine and Biological Sciences at Brown University,and on July 1, 2002, he began serving, retainingleadership responsibilities for the Division and for theCenter for Gerontology and Healthcare Research. Thisyear, Dr. John Murphy, Professor of Family Medicineand a national leader in aging, has been recruited(begins 7/03) as Associate Division Director, and DavidDosa, M.D., MPH, has been recruited as AssistantProfessor of Medicine. A geriatric medicine fellowshipprogram was developed and implemented; fullaccreditation was granted 6/02, and three fellows havesuccessfully completed their first year of fellowship.Clinical sites for training include RIH, TMH, Memorialand Butler Hospitals, Steere House Nursing Home,CareLink, Hospice Care of RI, East Avenue geriatricsprimary ambulatory care clinic, and multiple sites ofambulatory specialty care. Newly established clinicalprograms in geriatrics include ambulatory primary andconsultative care at the East Avenue office, in-patientprimary and consultative care at RIH and TMH, and aphysician-led home care program. A pilot in-patientprogram to enhance geriatrics care was begun on onenursing unit at TMH in the fall of 2002, under Dr.McNicoll’s leadership; 6-month outcome data are verypositive, and plans are underway for disseminationhospital-wide. The division continues to participate inother quality improvement initiatives at TMH and RIHto improve quality of care for older hospitalizedpatients. The Division’s nursing home practice hasdoubled, and major enhancement of care at ProvidenceHousing Authority sites has been achieved.

Research productivity of the Division has beenconcentrated in the Center for Gerontology andHealthcare Research (primarily health servicesresearch), one of the Public Health-related researchcenters at Brown. Research activities of Drs. Besdine,Gifford and Teno occur in the setting of the Center; itsproductivity has increased substantially over the pasttwo years in spite of no new faculty additions since2000. Its 13 full-time faculty hold more than 40 activegrants, funding is more than $5 million, andpublications 7/00-6/02 number nearly 200(unduplicated >125). The competitive renewalapplication for the federally funded post-doctoralresearch fellowship training grant in aging andhealthcare services was successful, bringing in$300,000/year for 5 years; in addition, a 5th fellow slotwas awarded to the program in a funding cycle thatresulted in reduction of slots for many competingprograms. The Gerontology Center collaborated with



Richard W. Besdine, M.D., Director, Professor ofMedicine, RST, Rhode Island Hospital, UniversityMedicine Foundation

James D. Burrill, M.D., Clinical Assistant Professor ofMedicine, Miriam Hospital, University MedicineFoundation

David R. Gifford, M.D., M.P.H., Assistant Professor ofMedicine, Rhode Island Hospital, UniversityMedicine Foundation

Lynn McNicoll, M.D., Assistant Professor of Medicine,Rhode Island Hospital, University MedicineFoundation

Aman Nanda, M.D., Assistant Professo of Medicine,Rhode Island Hospital, University MedicineFoundation

Tom J. Wachtel, M.D., Professor of Medicine, RhodeIsland Hospital, University Medicine Foundation

VOLUNTEER FACULTY

Marvin Kerzner, M.D., Clinical Assistant Professor,Miriam Hospital

Henry Izeman, M.D., Clinical Associate Professor ofMedicine, Miriam Hospital

Janet Manes, M.D., Clinical Instructor, MemorialHospital of RI


Richard W. Besdine, M.D.• Greer Professor of Geriatric Medicine, Brown

Medical School

• Interim Dean of Medicine and Biological Sciences,Brown University

• Member, Board of Directors and Executive Com-mittee of the Board, American Geriatrics Society

• Secretary, American Geriatrics Society 2001-02

• President-Elect, American Geriatrics Society 2002-03

• President, American Geriatrics Society, 2003-04

• Member, Board of Directors, American Federationfor Aging Research

• Chief Scientific and Clinical Officer, QualityPartners of Rhode Island

• Member, Board of Trustees, Education and ResearchFoundation, American Society of ConsultingPharmacists

• Invited Speaker, “Preventative Services for MedicareBeneficiaries”, 2 Medical Grand Rounds

• Plenary Speaker, NHLBI National Conference onCardiovascular Prevention

• Speaker, “Geriatric Assessment”, The MiriamHospital Residents Noon Conference

• Speaker, “History & Physical Examination of theElderly Patient”, The Miriam Hospital Residents NoonConference

• Top Doc Award, Geriatrics, Rhode Island MonthlyMagazine 2002, 03

Professor Tatar of Ecology and Evolutionary Biologyon submission of a large NIH Center Grant (PO1) tostudy biological aging in non-human primates; the sitevisit was positive and the resubmission in October hasa strong probability of funding.


James Burrill, M.D. , Clinical Assistant Professor

New Faculty


Aman Nanda, M.D. Fellow, Yale-New Haven Hospital, Assistant Professor

Yale School of Medicine

Lynn McNicoll, M.D. Fellow, Yale-New Haven Hospital, Assistant Professor

Yale School of Medicine

G E R I AT R I C S

James D. Burrill, M.D.• President, Rhode Island Medical Directors

Association, Rhode Island Chapter of the AmericanMedical Directors Association (AMDA)

• Executive Council Member, American College ofPhysicians: Rhode Island Chapter

• Member, Pharmacy & Therapeutics Committee,Lifespan Academic Medical Centers, Inc.

• Member, Blue Cross/Blue Shield of Rhode IslandMedicare Advisory Committee, Providence, RhodeIsland

• Member, Blue ChiP of Rhode Island CredentialsCommittee, Providence, Rhode Island

• Top Doc Award, Geriatrics, Rhode Island MonthlyMagazine


• CPT Coding & Documentation for Long Term Care, forthe Rhode Island Chapter of the American MedicalDirectors Association, Providence, Rhode Island

• Diagnosis & Treatment of Alzheimer’s Disease,multiple state-wide presentations, sponsored byNovartis, Pfizer, and Janssen Pharmaceuticalcompanies

• Collaborative Initiatives with State Survey Agencies,ADA Annual Meeting, San Diego, California

• Quality Improvement, How to Involve MedicalDirectors & Physicians, CareLink Board presentation,Providence, Rhode Island

David R. Gifford, M.D.• Finalist, AMDA Foundation/Pfizer 2001 Quality

Improvement Award, Quality Improvement in LongTerm Care

Aman Nanda, M.D.Invited Presentations:

• RIH noon conference – ‘Comprehensive GeriatricAssessment’ July 2003

• Grand Rounds at RIH/TMH- ‘Chronic Dizziness inOlder Persons’ July 2003

• TMH noon conference- ‘Comprehensive GeriatricAssessment’ June 2003

• Speaker, Geriatric Fundamental series – ‘ChronicDizziness in Older Persons’ July 2002

• Speaker, Core Curriculum for OB/GYN residents‘Preoperative Assessment of the Aging Patient’,Women & Infants’ Hospital, Providence, RhodeIsland

• Speaker, Geriatric Fundamental series – ‘PreoperativeAssessment of Aging Patient’ Aug 2002

• ‘Association among Depressive Symptoms,Antidepressant and Dizziness in Older Persons’,Annual Conference of the Gerontological Society ofAmerica, Chicago, IL

Tom J. Wachtel, M.D.• Chairman, Community Health Scientific Meetings

Committee, Brown University

• Chairman, Longitudinal Outpatient ProgramSubcommittee, Brown University

• Member, Resident Ranking for Matching Program(NRMP), Rhode Island Hospital

• Member, Quality Assurance Committee, RhodeIsland Hospital

• Member, Core Clerkship Committee

Medical Journal Reviewer:

• American Journal of Medicine

• Annals of Internal Medicine

• Journal of General Internal Medicine

• Journal of the American Geriatric Society

• Journal of the American Medical Association

• New England Journal of Medicine

Lynn McNicoll, M.D., F.R.C.P.C.• Top Doc Award for Women, Geriatrics, Rhode Island

Monthly Magazine 2002, 2003

Medical Journal Reviewer:

• Journal of the American Geriatric Society


• TMH noon conference “Comprehensive GeriatricAssessment” July 2002

• Rhode Island Quality Partners “Delirium in NursingHome Residents” March and June 2003

• RIH Grand Rounds “Update in Geriatrics: Deliriumin Older Persons” July 2003


Research and OtherScholarly ActivitiesFaculty Members of Study Sections andAdvisory Committees

Richard W. Besdine, M.D.• Consultant to HCFA Administrator of Geriatrics

• Chief Scientific and clinical Officer, Rhode IslandQuality Partners (PRO)

• Chair, Ad Hoc Review Panel, National Institute onAging, Loan Repayment Program

TEACHING ACTIVITIES


Richard W. Besdine, M.D.• Program Director, Geriatric Medicine Fellowship

Program, ACGME accreditation without comment6/02

• Director, Geriatrics Fellowship Programs(Medicine, Psychiatry) Lecture Course 2002

• Field Experience Director, Geriatrics; CommunityHealth Clerkship, Brown Medical Students

• Preceptor, Geriatrics Rotation for InternalMedicine Residents

James D. Burrill, M.D.• Member, Fellowship Executive Committee, Brown

Geriatric Medicine Fellowship Program, BrownUniversity

• Faculty Member, Geriatrics Fellowship LectureSeries: Evaluation & Management of the NursingHome Resident, Brown University

• Faculty Member, Geriatrics Fellowship LectureSeries: Pharmacokinetics & Pharmacodynamics inthe Geriatric Patient, Brown University

• Community Health Clerkship, Brown Medical School

• Group Leader, Brown Medical School AffinityGroup: Pathways I Medicine: Complimentary &Alternative Medicine

• Practice Preceptor, Community Health Rotation inGeriatric Medicine, Brown University

• Internal Medicine Resident Clerkship Preceptor,Brown University

David R. Gifford, M.D.• Lecturer, “Geriatric Assessment” Clinical Diagnosis

course for second-year medical students at BrownUniversity

• Co-Director, Geriatric Fellowship Curriculum inEvidence-Based Medicine and QualityImprovement, Brown University

Aman Nanda, M.D.• Preceptor, Community Health Clerkship, Brown

Medical School

• Acting Program Director, Geriatric MedicineFellowship Program since Nov. 2002

• Preceptor, Geriatric Rotation for Internal MedicineResidents at RIH

Tom J. Wachtel, M.D.• Preceptor, Bio-Med Course 381, Community Health

Clerkship, Brown University

• Preceptor, Seminars in Epidemiology, CommunityHealth Clerkship, Brown University

• Course Director, Bio-Med Course 315F,“Ambulatory Longitudinal Clerkship”, BrownUniversity

• Director, Geriatric segment of Medicine CoreClerkship, Brown University

• Preceptor, Community-based Geriatric Practicesand Home Care Program, Rhode Island Hospital

• Director and Preceptor, Required month-longgeriatrics rotation for internal medicine residents,Rhode Island Hospital

Lynn McNicoll, M.D., F.R.C.P.C.• Lecturer, Sexual Health Elective, Brown Medical

School

• Faculty Member, Geriatrics Fellowship LectureSeries: Delirium in Hospitalized Older Persons BrownUniversity

• Preceptor, Geriatrics Rotation for Internal MedicineResidents

GERIATRICS FELLOWSHIP PROGRAMDeparting Fellows

Steven LaFond, M.D.

Current Fellows

Steven LaFond, UCLA San Diego, CA, Family Medicine, UCLA San Diego, CA

Howard Nachamie, SUNY-Brooklyn, NY, IM, Lahey Clinic, Burlington MA

Rollin Wright, Albany Medical College, NY, IM (primary care, RIH) Brown U, Providence, RI

G E R I AT R I C S


Richard W. Besdine, M.D.• Merck Manual of Geriatrics (3rd ed. [Editorial

Board]). 2000, Merck, Rahway, NJ

• Trabucchi R, Maggi S, Besdine RW (Eds) SpecialIssue on Alzheimer’s Disease. Aging: Clinical andExperimental Research. 2001;13 (3):141-260.

• Book Chapter: Nanda A, Besdine RW. CHRONICDIZZINESS. In. Hazzard WR et al, editors.Principles of Geriatric Medicine and Gerontology.5th ed. New York. McGraw-Hill; 2003.

• Tangororang G, Kerins G, Besdine RW. Clinicalapproach: an overview. In: Cassel CK et al. (Eds.)Geriatric Medicine (4th Ed.) ; New York: Springer;2003; pp. 149-162.

James D. Burrill, M.D.• “Managing Psychosis in the Elderly: A Case Studies

Approach for the Primary Care Physician”, anACGME approved CD-ROM learning programproduced by CPE Communications, June 2001.

David R. Gifford, M.D.• Angelilli J., Gifford DR, Intrator O, Goazlo P,

Laliberte L, Mor V. Access to Post-Acute Home CareBefore and After the BBA. Health Affairs 2002September/October;21(5):254-264

• Mor V, Berg K, Angelleli J, Gifford, DR, Morris J,Moore T. The Quality of Quality Measurement inUS Nursing Homes. The Gerontologist. 2003;43(2):37-46.

• Mattke S, Reilly K, Martinez-Vidal E, McLean B,Gifford D. Reporting Quality of Nursing Home Careto Consumers: The Maryland Experience.International Journal of Quality in Healthcare.2003;13(2): 169-177.

• Mor V., Angelelli J, Gifford D, Morris J, Moore T.Benchmarking and quality in residential andnursing homes: lessons from the US. Int J GeriatrPsychiatry. 2003;18(3):258-66.

• Kissam S, Gifford DR, Parks P, Patry G, Palmer L,Wilkes L, Fitzgerald M, Petrulis A, Barnette L.Approaches to quality improvement in nursinghomes: Lessons learned from the six-state pilot ofCMS’s Nursing Home Quality Initiative BMCGeriatrics 2003, 3:2

Lynn McNicoll, M.D.• McNicoll L, Inouye SK. Prevalence Study of

Delirium in Critically Ill Older Patients. [abstract]Gerontologist. 2001;41(special issue 1):110.

• McNicoll L, Sobko-Koziupa, Zhang Y, Inouye SK.Detection of Delirium in the ICU: Validation of theCAM-ICU. [abstract] JAGS. 50(Supplement4);S156-7:2002.

• Pisani M, Redlich CA, McNicoll L, Inouye SK.Detection of Pre-existing Cognitive Impairment ina Medical ICU Using Two Proxy Scales. Am J RespirCrit Care Med 2002;165 (8):A253

• McNicoll L, Pisani M, Inouye SK. Occurrence andClinical Course of Delirium in Older ICU Patients.Am J Respir Crit Care Med 2002;165 (8):A29

Aman Nanda, M.D.• Tinetti ME, Baker D, Gallo W, Nanda A,

Charpentier P, O’Leary J. Trial of a RestorativeModel for Older Persons receiving an Acute Episodeof Home Care. JAMA. 2002;287:2098-2105.

• Book Chapter: Nanda A, Besdine RW. CHRONICDIZZINESS. In. Hazzard WR et al, editors.Principles of Geriatric Medicine and Gerontology.5th ed. New York. McGraw-Hill; 2003.

Tom J. Wachtel, M.D.• Mor V, Laliberte L, Petrisek A, Intrator O, Wachtel

T, Maddock P, Fland K. Impact of breast cancertreatment guidelines on surgeon practice patterns:Results of a hospital-based intervention. Surgery2000;128:847-61.


CLINICAL RESEARCH

Richard Besdine, M.D.

• LTYC Expert Advisory Panel, WV Medical Institute

• RIPQ Special Projects, RIQP Qualidigm, Qualidigm

Robert Crausman, M.D.

• Collaborative Program in Podogeriatrics, HealthResources & Services Administration

Joan Teno, M.D.

• Comparisons of the U.K. vs. U.S. Dying Experience,Commonwealth Fund

• Resident Assessment of Pain Management, Agencyfor Healthcare Research and Quality

• Development WWW Interface and Refinement ofToolkit, Robert Wood Johnson Foundation



Academic Year 2003 $1,265,417 $331,283 $1,596,700

H E M AT O L O G Y - O N C O L O G Y

Edward Wittels, M.D., Associate Professor of

Medicine; Interim Director of Hematology-

Oncology and Interim Director of The Medical

Oncology Division

Overview

The Brown University/Lifespan Hematology/

Oncology group was formed when The Miriam

Hospital Hematology/Oncology Division, the Rhode

Island Hospital Division of Hematology and the

Rhode Island Hospital Department of Medical

Oncology merged in 1999. Our mission is to achieve

academic excellence in basic research, clinical

research and education, and to provide the highest

quality of care to our patients.

The creation of a Comprehensive Cancer Center,

which is a collaborative effort to provide coordi-

nated and comprehensive care for cancer patients at

three Lifespan hospitals (The Miriam Hospital,

Rhode Island Hospital and Newport Hospital), has

now become a reality. Both the patients and the staff

appreciate the many benefits afforded by the new

Comprehensive Cancer Center at The Miriam

Hospital which opened in May 2002. Extensive

renovations to the George Clinic at Rhode Island

Hospital were completed as a temporary measure.

The groundbreaking ceremony for the Comprehen-

sive Cancer Center at Rhode Island Hospital was

held on April 28, 2003 with an anticipated opening

in February 2004.

A recent goal has been the establishment of multi-

disciplinary clinics for all the major malignancies.

This conveniently allows the patient to receive the

expertise of the surgeon, radiation oncologist and

medical oncologist at the time of their first visit.

Presently, upper GI and melanoma multidisciplinary

clinics are up and running at Rhode Island Hospital.

A thoracic multidisciplinary tumor board has been

implemented at each hospital. Future multi-discipli-

nary clinics are being planned for head and neck

cancer as well as breast cancer.

In the clinical arena, three of our physicians, Drs.

Fred Schiffman, Anthony Mega, and Sundaresan

Sambandam were included in the “Rhode Island

Monthly” magazine’s list of “Top Docs.” Dr. Mega

was also honored with the “Teacher of the Year

2001-2002” award by the Hematology/Oncology

fellows.

HEMATOLOGY-ONCOLOGY

Our laboratory and clinical researchers distinguished

themselves through national appointments as well as

being awarded significant research grants.

A Center of Biomedical Research Excellence (COBRE)

award of $8.2 million has established the Center for

Cancer Research Development under the leadership of

Dr. Douglas Hixson as Principal Investigator and Dr.

Nancy Thompson as Deputy Director. The mission of

the Center is to foster outstanding interactive,

laboratory-based cancer research focused on the


Molecular and Cellular Pathogenesis of Cancer by

mentoring promising junior investigators and

establishing state of the art core facilities.

Dr. Douglas Hixson served as a member of the

National Institute of Environmental Health Services

(NIEHS) Study Section, Review of ToxicoGenomics

Consortium Member Applications, 2001 and was the

Chair and organizer of the 12th International CEA

Symposium in Providence, RI. Dr. Hixson is on the

Editorial Board for “Hepatology,” a member of the

Program Committee for the American Society for

Investigational Pathology and is Vice President and co-

founder of ProThera Biologics in East Providence, RI.

He received an RO1 grant funded by the National

Institutes of Health for a project entitled “Genesis of

Liver Carcinomas with Oval Cell Traits.”

Dr. Nancy Thompson is the Principal Investigator for a

National Institutes of Health (NIH) RO1 Grant

entitled “Expression and Role of TA1 Oncofetal Gene

in Liver Cancer” and an American Institute for Cancer

Research (AICR) Grant entitled “Amino Acid

Regulated Gene Expression in Tumorigenesis.”

Dr. Alan Rosmarin chairs the American Cancer

Society’s Leukemia, Immunology and Blood Cell

Development Study Section and is a member of the

National Cancer Institute Subcommittee C (Program

Projects).

Dr. Deborah Britt is the Principal Investigator for

two grants that were awarded – a Lifespan

Developmental Grant entitled “Examination of

Differential Expression of a Novel Protein, LYRIC, in

Normal Rat Liver and Hepatocellular Carcinoma”

”and a grant from the U.S. Army Prostate Cancer

Research Program entitled “Examination of a Novel

Protein, LYRIC, and Its Involvement in Prostate

Tumor Suppression Mediated by the Cell Adhesion

Molecule CEACAM1-L.”

Dr. Yow-Pin Lim was awarded a Lifespan

Developmental Grant for a project entitled

“Granzyme in Sepsis,” which will examine the role of

lymphocyte serine proteases (granzymes) in

inflammation and sepsis. He also received grants

from The Slater Center for Biological Research and

NIH/NIGMS (SBIR Phase I). Dr. Lim is the

President and co-founder of ProThera Biologics, a

start-up biotechnology company, in East Providence,

Rhode Island. Dr. Loren Fast was awarded a Rhode

Island Cancer Council Grant.

Dr. Howard Safran is the Principal Investigator for

an RTOG-sponsored adjuvant pancreatic cancer

trial, which is the largest adjuvant pancreatic trial

ever performed in the United States. He also directs

a Radiation Therapy Oncology Group (RTOG) trial

for advanced pancreatic cancer. Dr. William Sikov

served as a Principal Investigator for a national study

Alan Rosmarin,

Associate Professor of

Hematology-Oncology;

Interim Director of

Hematology Division

and Director of Brown

University Oncology

Group (BrUOG)


in advanced breast cancer, which he presented at the

American Society of Clinical Oncology (ASCO)

meeting in May 2002. He also serves as a member of

the Board of Directors of Cancer and Leukemia

Group B (CALGB) and as the Principal Investigator

representing Rhode Island. Dr. Anita Kestin is the

Principal Investigator for the Prevention of Recurrent

Venous Thromboembolism (PREVENT) study. The

PREVENT trial evaluates the efficacy of prolonged

treatment with low-dose warfarin in the secondary

prevention of venous thromboembolism.

Dr. Gary Strauss was recently recruited to fill a

fulltime faculty position in Hematology/Oncology at

Rhode Island Hospital. Dr. Strauss received his M.D.

from Yale University and M.P.H. from Harvard School

of Public Health. While he is an experienced clinician

in all aspects of Medical Oncology, he is particularly

interested in breast and lung cancers. He is a

nationally recognized researcher in lung cancer and

has been in the forefront of the controversy regarding

the efficacy of lung cancer screening. Dr. Strauss’s

clinical expertise and research accomplishments make

him an invaluable addition to the Division of

Hematology/Oncology.

We are proud to report that five of our fellows were

authors of abstracts at the American Society of

Clinical Oncology (ASCO) meeting in May 2002. One

of the fellows, Dr. Vanessa Johnson, received both a

Merit Award and the Pain Merit Award, which was

presented to the author who submitted the best

abstract paper on the subject of pain management. Dr.

Johnson was honored during the Opening Ceremony

and was also featured in the ASCO daily newsletter.

The Cancer Program at Rhode Island Hospital as well

as the Cancer Program at The Miriam Hospital were

surveyed by the Commission on Cancer of the

American College of Surgeons and both were awarded

the maximum accreditation of three years.

Three members of The Miriam Hospital Cancer

Control Committee who are actively involved in

community activities are Marsha Weiss, RN, MS,

Patricia Grossi, RN, BSN, OCN, and Kathleen

Higginbotham, LICSW. Ms. Weiss is the Director of

Lifespan Community Health Services, which

coordinates community health education, screenings,

outreach programs and follow-up for the Lifespan

affiliates in Rhode Island. She also serves as the local

Chair for the National Cancer Survivors Day planning

group. Ms. Grossi is an Oncology Nurse Clinician at

The Miriam Hospital and serves on the Board of

Directors of The Leukemia and Lymphoma Society.

Ms. Higginbotham, who is an Oncology Clinical

Social Worker at The Miriam Hospital, also volunteers

for The Leukemia and Lymphoma Society. Both Ms.

Grossi and Ms. Higginbotham coordinate and

participate in numerous activities such as National

Cancer Survivors Day as well as various support and

educational programs, some of which are held in

conjunction with the American Cancer Society. They

also have been invited to address PTA meetings about

speaking to children about cancer and they have

conducted tours of the treatment area for young

children of cancer patients. Recently Pat Grossi has

taken a job at another institution and we are in the

process of hiring an equally accomplished and

experienced oncology nurse to fill her position.


Edward Wittels, M.D., Director, Hematology/Oncology,Associate Professor, Miriam Hospital, UniversityMedicine Foundation

Deborah Britt, Ph.D., Assistant Professor, Oncology,Rhode Island Hospital

James Butera, M.D., Clinical Assistant Professor,Hematology, Rhode Island Hospital, UniversityMedicine Foundation

James Crowley, M.D., Professor, Hematology, MemorialHospital

Loren Fast, Ph.D., Associate Professor, Hematology,Rhode Island Hospital

Mary Anne Fenton, M.D., Clinical Instructor, Hematol-ogy, Rhode Island Hospital, University MedicineFoundation

Michelle Haskell, Ph.D., Assistant Professor (Res.)Rhode Island Hospital

Douglas Hixson, Ph.D., Professor, Oncology, RhodeIsland Hospital

Vanessa Johnson, M.D., Instructor (Research) MiriamHospital

Anita Kestin, M.D., Clinical Assistant Professor,Hematology, Rhode Island Hospital, UniversityMedicine Foundation

Yow Pin Lim, M.D., Ph.D., Assistant Professor,Oncology, Rhode Island Hospital

Leslie Lockridge, M.D., Assistant Professor, MemorialHospital


Anthony Mega, M.D., Assistant Professor,Hematology, Miriam Hospital, University MedicineFoundation

Ahmed Nadeem, M.D., Assistant Professor, MemorialHospital

Neal Ready, M.D., Assistant Professor, Oncology,Rhode Island Hospital, University MedicineFoundation

Alan Rosmarin, M.D., Associate Professor, Hematol-ogy/Oncology, Miriam Hospital , UniversityMedicine Foundation

Howard Safran, M.D., Assistant Professor, Oncology,Miriam Hospital, University Medicine Foundation

Fred Schiffman, M.D., Professor, Hematology, MiriamHospital, University Medicine Foundation

William Sikov, M.D., Clinical Assistant Professor,Oncology, Miriam Hospital, University MedicineFoundation

Gary Strauss, M.D., M.P.H., Brown faculty appoint-ment pending, Rhode Island Hospital, UniversityMedicine Foundation

Rochelle Strenger, M.D., Clinical Assistant Professor,Hematology, Miriam Hospital , University MedicineFoundation

Nancy Thompson, Ph.D., Professor, Oncology, RhodeIsland Hospital

VOLUNTEER FACULTY

Kwang Ahn, M.D., Clinical Assistant Professor,Oncology, Roger Williams Medical Center

Joseph DiBenedetto, Jr., M.D., Clinical Assistant Profes-sor, Hematology/Oncology, Rhode Island Hospital

Nancy Freeman, M.D., Clinical Associate Professor,Hematology, VA Medical Center

Linda Hassan, M.D., Clinical Assistant Professor,Memorial Hospital

Peter Hoffmann, M.D., Clinical Assistant Professor,Hematology, Miriam Hospital

Plakyil Joseph, M.D., Clinical Assistant Professor,Oncology, Roger Williams Medical Center

A. Sattar Memon, M.D., Clinical Associate Professor,Oncology, Memorial Hospital

Vishram Rege, M.D., Clinical Associate Professor,Oncology, Rhode Island Hospital

Peter Rintels, M.D., Clinical Assistant Professor,Hematology, Rhode Island Hospital

Sundaresan Sambandam, M.D., Clinical AssistantProfessor, Oncology, Rhode Island Hospital

Anthony Testa, M.D., Clinical Instructor, Oncology, St.Joseph’s Hospital

Kathy Theall, M.D., Clinical Instructor, Hematology/Oncology, Memorial Hospital

Anthony Thomas, D.O., Clinical Assistant Professor,Hematology, Rhode Island Hospital

Fred Vohr, M.D., Clinical Assistant Professor,Hematology/Oncology, Rhode Island Hospital

Francis Cummings, M.D., Adjunct Associate Professor,Oncology, Roger Williams Medical Center

A. Raymond Frackelton, Ph.D., Adjunct AssociateProfessor, Oncology, Roger Williams Medical Center

Seth Rudnick, M.D., Adjunct Associate Professor,Oncology, Rhode Island Hospital

Philip Schein, M.D., Adjunct Professor, Oncology,Rhode Island Hospital

Alan Weitberg, M.D., Adjunct Professor, Oncology,Roger Williams Medical Center


Thomas Myers, Clinical Associate Professor, Memorial HospitalPeter Hoffmann, Clinical Assistant Professor, Miriam Hospital

New Faculty

James Butera, M.D., Clinical Assistant Professor, Rhode Island HospitalGary Strauss, M.D., MPH, Appointment pending,Rhode Island HospitalLeslie Lockridge, M.D., Assistant Professor, Memorial HospitalAhmed Nadeem, M.D., Assistant Professor, Memorial HospitalVanessa Johnson, M.D., Instructor (Research) Miriam HospitalMichelle Haskell, Ph.D., Assistant Professor (Res.) Rhode Island Hospital



Loren Fast, PhDInvited presentations:

• Two seminars at the Blood Center of the Pacific,SanFrancisco, CA

Mary Anne Fenton, M.D.Invited presentation:

• “Pathophysiology of Breast, Cervical andEndometrial Cancers” at University of Rhode Island,Kingston, RI

Douglas Hixson, PhD • Chair and organizer, 12th International CEA/PSG

Symposium, Providence, RI; Consultant,Octapharma Therapeutics, Vienna, Austria

• Member, Editorial Board of “Hepatology”

• Member, Program Committee for American Societyfor Investigational Pathology

• Vice President, co-founder of Prothera Biologics,East Providence, RI


• “Hepatic Stem Cells, An Older and Wiser Alternativeto Embryonic Stem Cells” at UTMDAH Cancer Cen-ter, Science Park Research Division, Smithville, TX

• “Stages in Hepatic Ductal Cell DevelopmentDefined by Surface Reactive MonoclonalAntibodies” at Albert Einstein College of Medicine,Bronx, NY “Hepatic Stem Cells of Ductal Origin” atLoyola University, New Orleans, LA

Anita Kestin, M.D.Invited presentations:

• “Coagulation Disorders” at University of RhodeIsland, Kingston, RI

• “Hematology Update: Hypercoagulable States” atNewport Hospital’s Grand Rounds, Newport, RI

Yow Pin Lim, M.D., PhDInvited presentations:

• “Development of Monoclonal Antibody for EarlyDetection of Colon Cancer” at BiochemistrySeminar at the Free University, Berlin, Germany

• “Inter-alpha inhibitors in Sepsis and Cancer” atInstitute for Immunology Zagreb and Dr. Josip

Hospital, Zagreb, Croatia

• “Role of Protease Inhibitors in Neonatal Sepsis” at28th Annual New England Conference on PerinatalResearch, Chatham, MA

Anthony, Mega, M.D. • “TopDoc” – Rhode Island Monthly Magazine


• “Communicating Options in Prostate Cancer” atSchwartz Center Rounds, Memorial Hospital ofRhode Island, Pawtucket, Rhode Island

• “High Risk Local Prostate Cancer – Can WeImprove Outcome?” at Brown University OncologyGroup Education Advisory Board, Edgartown, MA

• “From Herbs to Chemotherapy, Choices in theManagement of the Patient with Androgen-Independent Prostate Cancer” at Caritas GoodSamaritan Medical Center, Brockton, MA

• “Update on Prostate Cancer” at CRI Communica-tions on The Rhode Island Health Update program,Providence, RI

Neal Ready, M.D., PhDInvited presentation:

• Abstract/poster “Induction Weekly Paclitaxel andCarboplatin (IT) followed by concurrent Paclitaxel,Carboplatin and Radiotherapy (CRT) in AdvancedHead and Neck Squamous Cell Cancers (HN-SCC)”at American Society of Clinical Oncology Meeting,Orlando Florida

Committee:

• Chairman, Thoracic Committee, Brown UniversityOncology Group

• Society: Member, Executive Committee, NewEngland Cancer Society

Alan Rosmarin, M.D.Invited presentations:

• “Myelodysplastic Syndromes: ContemporaryManagement and Novel Approaches” at Beth IsraelDeaconess Medical Center, Boston, MA

• “CML: A Model Disease for Targeted Therapy” atRhode Island Hospital Grand Rounds, Providence,RI

• “Current Approaches and Future Trends in CancerTherapy” at Brown University Oncology Group(BrUOG) Seminar, Edgartown, MA

·• “Myelodysplastic Syndromes: ContemporaryManagement and Novel Approaches” at BostonUniversity Medical Center, Boston, MA

• “Workshop on Myeloid Development” at AnnualMyeloid and Stem Cell Workshop, Philadelphia, PA

• “GABP (GA Binding Protein), Sp1 and p300Physically and Functionally Interact to RegulateMyeloid Transcription of CD18 in Response to


Retinoic Acid” at Fifth International Meeting onMyeloid Stem Cell Development and Leukemia,Annapolis, Maryland.

·• “GA Binding Protein (GABP) in the Regulation ofMyeloid Gene Expression and Differentiation” atChicago Department of Biochemistry and MolecularBiology at University of Illinois, Chicago, IL

Howard Safran, M.D. Invited presentations:

• “Neoadjuvant Herceptin, Paclitaxel and Cisplatin andRadiation for Adenocarcinoma of the Esophagus” atthe Eighth International Conference on Gastroin-testinal Malignancies, Washington, D.C.

• “A phase II trial of Herceptin and Gemcitabine forMetastatic Pancreatic Cancers that Overexpress HER-2/neu” at ECCO in Lisbon, Portugal

Fred Schiffman, M.D.• “Top Doc” – Rhode Island Monthly Magazine

William Sikov, M.D.Invited presentations:

• “Multicenter, 3-arm randomized study of high-doseweekly paclitaxel versus standard-dose weeklypaclitaxel for metastatic breast cancer” at AmricanSociety of Clinical Oncology (ASCO) annualmeeting, Orlando, FL

• “Metastatic Breast Cancer: Beyond Taxanes andAnthracyclines” at Breast Cancer Forum, PresbyterianHealthcare, Charlotte, NC “Metastatic Breast Cancer:Beyond Taxances and Anthracyclines” at HarvardVanguard Medical Associates, Boston, MA

• “Cancer Clinical Trials and Older Patients” atCombined Onoclogy/Geriatrics Symposium,Providence, RI

• “The Changing Face of Hormonal Therapy” atOncology Grand Rounds, Dartmouth HitchcockMedical Center, Hanover, NH

Gary Strauss, M.D., MPHInvited presentations:

• “Island-Lake Model and Cancer: Implications forRandomization Failure in Randomized PopulationTrials” at Working Group in Quantitative Methodsin Cancer: Harvard School of Public Health, Boston,MA

• “Should We Be Screening for Cancer?” at NationalCouncil of Jewish Women, Providence, RI

• “Cancer Screening is Effective and Cost-Effective:Pro” at American Association of Thoracic Surgery,Boston, MA

• “Smoking-related Adenocarcinoma of the Lung:Now the Most Common Cause of Cancer Death inthe United States” at American Society of ClinicalOncology Annual Meeting, Chicago, IL

Rochelle Strenger , M.D.• Co-recipient of the Rhode Island Medical Women’s

Association’s “Woman Physician of the Year Awardfor 2001”

Nancy Thompson, PhDInvited presentations:

• “Oncofetal and Amino Acid-Responsive hepaticLAT1/CD98 Expression” at International Society ofDifferentiation Meeting, Lyon, France

• “Mentoring and Minority Recruiting inPathobiology” at American Society for InvestigativePathology Graduate Program Director’s Workshop,San Diego, CA

Edward Wittels, M.D.• Elected to faculty of the Alpha Omega Alpha Honor

Medical Society, Brown Medical School


HEMATOLOGY/ONCOLOGY FELLOWSHIP PROGRAM

GRADUATES 2002

Fellow Medical School Residency Program Post-fellowship Position

Vanessa Johnson, M.D.

Ahmed Nadeem, M.D.

Nadia Ramdin, M.D.

GRADUATES 2003

Maria Constantinou, M.D.

Wojciech Dolata, M.D.

Humera Khurshid, M.D.

Cornell UniversityMedical College, NewYork, NY

King Edward MedicalCollegeLahore, Pakistan

UMDNJ – Robert WoodJohnson School ofMedicine, NJ

Ross UniversityPortsmouth, Dominica

Academy of Medicine,Poznan, Poland

Aga Khan UniversityMedical College, Karachi,Pakistan

Brown General InternalMedicine, Rhode IslandHospital, Providence, RI

Yale University, BridgeportHospital, Bridgeport, CT

Boston University, RogerWilliams Medical Center,Providence, RI

Yale University, NorwalkHospital, Norwalk, CT

Michigan State University,McLaren RegionalMedical Center, Flint, MI

University of Connecticut,John Dempsey Hospital,Farmington, CT

National Cancer InstitutePost-doctoral R25 TrainingGrant, Providence, RI

Full-time Staff, MemorialHospital of Rhode Island,Pawtucket, RI

Private practice ofHematology/Oncology, Ft.Lauderdale, FL

Private practice withVincent Armenio, M.D., EastProvidence, RI

Practice in Canada

Private practice, UniversityMedical Group, Warwick, RI

2001-2003

Fellow Medical School Residency Program

Debra Holik, M.D.

Katrina Rolen, M.D.

Amanda Sun, M.D., Ph.D.

James Tsai, M.D.

George Zahrah, M.D.

2002-2003

Douglas Brandoff, M.D.

Bharti Chauhan, M.D.

Samir Desai, M.D.

Ronald Harris, M.D.

Linda McMorrow-Ries,M.D.

New York Medical College,Valhalla, NY

St. Louis University School ofMedicine, St. Louis, MO

Sun Yat-sen University of MedicalSciences, Guangzhou, P.R.China

St. George’s University, St. George’s,Granada

University of Ancona, Ancona, Italy

Mt. Sinai School ofMedicine, New York, NY

Pandit JJM Medical College, Raipur,India

Northeastern Ohio Universities ofMedicine, Rootstown, OH

Lake Erie College of OsteopathicMedicine, Erie, PA

University of Vermont, Burlington,VT

Brown Medical School, Internal Medicine –The Miriam & Rhode Island Hospitals

St. Louis University Health Sciences Center,St. Louis, MO

Yale University, Norwalk Hospital, Norwalk, CT

UMDNY – New Jersey Medical School,Newark, NJ

Yale University, Danbury Hospital,Danbury, CT

Lahey Clinic, Burlington, VT

Brown Medical School, Internal Medicine –Memorial Hospital of Rhode Island

Summa Health System, Akron, OH

Temple University, Conemaugh Valley MemorialHospital, Johnstown, PA

Brown Medical School, Internal Medicine –Rhode Island Hospital


Research and OtherScholarly ActivitiesFACULTY MEMBERS OF STUDYSECTIONS AND ADVISORY COMMITTEES

Loren Fast, PhD• Member, ZRG H10 study section at NIH

Douglas Hixson, PhD• Member, NIEHS study section, Review of Toxico-

Genomics Consortium Member Applications

Neal Ready, M.D., PhD• Study section: Chair, Cancer and Leukemia Group B

Protocol #30106: “ZD-1839 (NSC# 715055) withInduction Paclitaxel and Carboplatin followed byeither Radiation or Concomitant Radiation withWeekly Paclitaxel and Carboplatin in Stage III Non-small Cell Lung Cancer, a Phase II Study”

Alan Rosmarin, M.D.• Chairman, American Society of Hematology

Simultaneous Session “Regulation of Transcriptionin Hematopoiesis” at annual meeting, Orlando, FL

• Member, Myeloid Subcommittee, American Societyof Hematology

• Chairman, American Cancer Society Leukemia,Immunology, and Blood Cell Development StudySection

• Member, National Cancer Institute Subcommittee C

Howard Safran, M.D.• Member, Gastrointestinal Oncology Committee,

Radiation Therapy Oncology Group (RTOG)

• Ad Hoc Member, Study Section, “Rapid Access toIntervention Development;” Medical OncologyChairman, RTOG national protocol, “A Phase II Trialof External Irradiation and Weekly Paclitaxel forNon-Metastatic Unresectable Pancreatic Cancer”

• Medical Oncology Chairman, RTOG/Intergroupnational protocol, “A Phase III Study of Pre and PostChemoradiation 5-FU vs. Gemcitabine forPostoperative Adjuvant Treatment of ResectedPancreatic Adenocarcinoma”

• Medical Oncology Chairman, RTOG national proto-col, “Phase II Study of Paclitaxel, Gemcitabine andRadiation Followed by the Farnesl TransferaseInhibitor R115777 for Locally Advanced PancreaticCancer”

• Medical Oncology Liaison to Translation ResearchProgram, RTOG

• Medical Oncology Chairman for upcoming RTOGprotocol testing a ras peptide vaccine with chemo-radiation as adjuvant therapy for pancreatic cancer

Anthony Mega, M.D.• Chairman, Genitourinary Subcommittee, Brown

University Oncology Group;

• Member, Scientific Review Board, Brown UniversityOncology Group

Fred Schiffman, M.D.• Co-Chairperson, Committee on Clinical Appoint-

ments and Promotions, Brown UniversityDepartment of Medicine

• Chairperson, Chiefs of Medicine of Federation ofJewish Philanthropies Hospitals

• Governor, American College of Physicians/American Society of Internal Medicine

Nancy Thompson, PhD• Chair, American Society of Investigative Pathology

(ASIP) Committee on Career Development,Women and Minorities; Member, ASIP Council

• Chair, Federation of American Societies of Experi-mental Biology (FASEB) Excellence in ScienceAward Committee

• ASIP Delegate to AXXS 2002 Meeting inWashington, D.C., sponsored by Office of Researchin Women’s Health

• Co-chair and organizer, American Society forInvestigative Pathology Career DevelopmentWorkshop: “Playing to Win: Elements of Success”in San Diego, CA

TEACHING ACTIVITIES

EDUCATION HONORS

Anthony, Mega, M.D.• Dean’s Teaching Excellence Award, BioMed 281:

Pathophysiology – Hematology, Brown MedicalSchool

• Preceptorship Award – Brown Medical School,Rhode Island Hospital, The Miriam Hospital

• “Teacher of the Year 2001-2002” – Brown MedicalSchool, Hematology/Oncology Fellowship Program

Fred Schiffman, M.D.• Senior Class Award from Brown University Medical

School Class of 2001 in recognition of support anddedication to teaching

• Brown University Dean’s Teaching ExcellenceAward-2002

Edward Wittels, M.D.• Dean’s Teaching Excellence Award, BioMed 281:

Pathophysiology – Hematology, Brown MedicalSchool



James Butera, M.D.• BioMed 281, Small group leader• BioMed 326, Preceptor• Preceptor, Hematology/Oncology Fellowship Program

(RIH)

James Crowley, M.D.• Preceptor, Hematology/Oncology Fellowship Program

(Memorial)

Mary Ann Fenton, M.D.• BioMed 326 Preceptor• Preceptor, Hematology/Oncology Fellowship Program

(RIH)

Nancy Freeman, M.D.• Preceptor, Hematology/Oncology Fellowship Program

(VAMC)

Anita Kestin, M.D.• BioMed 281, Lecturer, small group leader• BioMed 326, Preceptor• Preceptor, Hematology/Oncology Fellowship Program

(RIH)

Anthony Mega, M.D.• Co-director, Preceptor, Hematology/Oncology

Fellowship Program• BioMed 281, Lecturer, small group leader• BioMed 301, Preceptor• BioMed 323, Preceptor

Ahmed Nadeem, M.D.• BioMed 281, Small group leader (2002-2003)

Neal Ready, M.D.• BioMed 281, Lecturer• BioMed 326 Course leader (RIH)• Preceptor, Hematology/Oncology Fellowship Program

(RIH)

Alan Rosmarin, M.D.• Co-director, preceptor, Hematology/Oncology

Fellowship Program• BioMed 281, Course co-leader, lecturer, small group leader• BioMed 283,Instructor

Howard Safran, M.D.• BioMed 323 Preceptor• BioMed 326 Preceptor• Preceptor, Hematology/Oncology Fellowship Program

(TMH)

Fred Schiffman, M.D.• Associate Program Director, Categorical and

Preliminary Internal Medicine Residency• Preceptor, Hematology/Oncology Fellowship Program

(TMH)• BioMed 281, Lecturer• BioMed 323, Preceptor

William Sikov, M.D.• BioMed 281, Lecturer• BioMed 323Preceptor• Preceptor, Hematology/Oncology Fellowship Program

(TMH)

Rochelle Strenger, M.D.• BioMed 323Course leader (TMH)• BioMed 373-374Course leader (TMH)• Preceptor, Hematology/Oncology Fellowship Program

(TMH) (2002-2003)

Kathy Theall, M.D.• BioMed 281, Small group leader• Preceptor (Memorial), Hematology/Oncology

Fellowship Program

Edward Wittels, M.D.• Preceptor (TMH), Hematology/Oncology Fellowship

Program• BioMed 281, Course co-leader, lecturer, small group leader• BioMed 301, Course leader (TMH)• BioMed 323, Preceptor


James Butera, M.D.• Yango A, Morrissey P, Monaco A, Butera J, et al. Success-

ful treatment of tacrolimus-associated thromboticmicroangiopathy with sirolimus conversion and plasmaexchange. Clin Nephrol 2002 Jul; 58(1):77-8.

Loren Fast, Ph.D.• Fast L, DiLeone G, Edson C, Purmal A. INACTINE

PEN110 treatment functionally inactivates the PBMNCpresent in RBC units: Comparison to the effects of expo-sure to g-irradiation. Transfusion 2002; 42:1318 - 25.

• Fast LD, DiLeone G, Edson C, Purmal A. Inhibition ofmurine GVHD by INACTINE PEN110 treatment.Transfusion 2002; 42:1326-32.

• Fast L. The effect of exposing murine splenocytes toUVB light, psoralen plus UVA light or g-irradiation onin vitro and in vivo immune responses. Transfusion2003; 43:576-83.

• Fast L. Genotypic regulation of alloantibody productionin response to ultraviolet B irradiated allogeneic donorcells. Transfusion 2003; in press.

Mary Anne Fenton, M.D.• Fenton, MA. Breast cancer update. Med Health RI 2002

Jan; 85(1):10-4. Review.

• Dupuy D, Chauhan B, Ready N, DiPetrillo T, Gaissert H,Fenton MA. Radiofrequency ablation (RFA) followed byconventional radiotherapy (RT) for inoperable non-small cell lung cancer (NSCLC). ASCO Proceedings2003 June; 22:654,abstr. #2632.

Douglas Hixson, Ph.D.• Gordon GJ, Coleman WB, Hixson DC, Grisham JW.

Liver regeneration in rats with retrorsine-induced


hepatocellular injury reveals the existence of a novelliver progenitor cell population. Am J Pathol 2000;156:607-19.

• Hixson DC, Brown J, McBride A, Affigne SA. Differen-tiation status of rat ductal cells and ethionine-inducedhepatic carcinomas defined with surface-reactivemonoclonal antibodies. Exper and Mole Pathol 2000;68:152-69.

• Estrera VT, Chen DT, Luo W, Hixson DC, Lin SH.Signal transduction by the CEACAM1 tumorsuppressor. J Biol Chem 2001; 276:15547-53.

• Makarovskiy AN, Siryaporn E, Hixson DC, Akerley W.Survival of docetaxel-resistant prostate cancer cells in-vitro depends on phenotype alterations and continuityof drug exposure. Cell Mole Life Sci 2002; 59:1198-211.

• Hixson DC. Animal models for assessing the contribu-tion of stem cells to liver development. In: Sell S; StemCell Handbook.Towanda, NJ. Humana Press 2003:353-66.

Anthony Mega, M.D.• Lopez F, Mega A. Aortitis as a manifestation of myelodys-

plastic syndrome. Postgrad Med J 2001 Feb; 77:116-8.

Alan Rosmarin, M.D.• Sedivy JM, Vogelstein B, Liber HL, Hendrickson E,

Rosmarin AG. Gene targeting in human cells withoutisogenic DNA. Science 1999; 283(1):5.

• Khurana TS, Rosmarin AG, Shang J, Krag TOB, Das S,Gameltoft S. Activation of utrophin promoter byheregulin via the ets-related transcription factorcomplex GABP/. Mol Biol Cell 1999; 10(6):2075-86.

• Gupta AK, Zibello T, Simkevich CP, Rosmarin AG,Berliner N. Sp1 and C/EBP are necessary to activatethe lactoferrin gene promoter during myeloiddifferentiation. Blood 2000; 95:3734-41.

• Bush TS, St. Coeur M, Resendes KK, Rosmarin AG. GAbinding protein (GABP) and Sp1 are required, alongwith retinoid receptors to mediate retinoic acidresponsiveness of CD18 (B2 Leukocyte Integrin): anovel mechanism of transcriptional regulation inmyeloid cells. Blood 2003; 101:311-7.

• Rosmarin AG, Resendes KK, Yang Z, McMIllan J,Fleming SL. GA binding protein (GABP) transcriptionfactor: a review – GABP as an integrator of intracellu-lar signaling and protein-protein interactions. BloodCells, Molecules, and Diseases 2003, in press.

Howard Safran, M.D.• Safran H, Gaissert H, Akerman P, Hesketh P, Chen

MH, Moore T, Koness J, Graziano S, Wanebo H.Paclitaxel , cisplatin and concurrent radiation foresophageal cancer. Cancer Invest 2001; 1:1-7.

• Safran H, Moore T, Iannitti D, DiPetrillo T, Akerman P,Cioffi W, Harrington D, Quirk D, Ratesh R, Cruff D,Vakharia J, Vora S, Savarese D, Wanebo H. Paclitaxel andconcurrent radiation for locally advanced pancreaticcancer. Int J Radiat Oncol Biol Phys 2001; 49:1275-9.

• Safran H, Rathore R. Paclitaxel as a radiation sensitizerfor locally advanced pancreatic cancer. Crit Rev OncolHematol 2002 Jul; 43(1):57-62.

• Safran H, King TC, Steinhoff MM, Rathore R, MangrayS, Chai L, Berezein K, Moore T, Iannitti D, PasquarielloT, Akerman P, Quirk D, Goldstein L, Reiss P, Mass Rand Tantravahi U. Overexpression of the HER-2/neuoncogene in pancreatic adenocarcinoma. Am J ClinOncol 2001; 24:496-9.

Fred Schiffman, M.D.• Akhtar M, Hussain SI, Lamberton P. Schiffman FJ.

Resolution of methimazole-induced agranulocytosiswith the use of human granulocyte colony stimulatingfactor (G-CSF). Geriatrics 2000; 55(2):89-91.

• Sikov W, Schiffman FJ, Weaver M. Schulman R,Dyckman J. Griffith R, Torgan P. Splenosis presentingas occult gastrointestinal bleeding. AM J. Hematol2000; 65(1):56-61.

• Lopez F, Mega A, Schiffman FJ, Vaidyan P. Aortitis as amanifestation of myelodysplastic syndrome.Postgraduate Med J 2001; 77:116-8.

• Tuohy K, Nicholson W, Schiffman FJ. Agitation bysedation. Lancet 2003; 361:308.

• Lee SI, Honiden S, Fain EB, Schiffman FJ, Tammaro D.Severe hyponatremia caused by an intrasella carotidartery aneurysm. Med and Health Rhode Island 2003Feb; 86(2): 52-5.

William Sikov, M.D.• Akerley W, Rathore R, Ready N, Leone L, Sikov W,

Safran H, Kennedy T. A phase I study of a weeklyschedule of paclitaxel and carboplatin in patients withadvanced carcinoma. Cancer. 2002; 95(9):2000-5

• Sikov WM. Locally advanced breast cancer. CurrentTreatment Options in Oncology 2000; 1:228-38.

Rochelle Strenger, M.D.• Legare RD, Strenger R. Adjuvant therapy in breast

cancer. Obstet Gynecol Clin North Am 2002 Mar;29(1):201-8, ix. Review.

Nancy Thompson, Ph.D.• Diah SK, Padbury JF, Campbell WA, Britt D,

Thompson NL. Molecular cloning of the rat TA1/LAT-1/CD98 light chain gene promoter. Biochimica etBiophysica Acta 2001; 1518:267-70.

• Campbell WA, Thompson NL. Overexpression of LAT-1/CD98 light chain is sufficient to increase system Lamino acid transport activity in mouse hepatocytesbut not fibroblasts. J Biol Chem 2001; 276:16877-84.

Edward Wittels, M.D.• Wittels EG, Siegel RD, Mazur EM. Thrombocytopenia

in the intensive care unit setting. J Intensive Care Med1990; 5:224-40.

• Akerley W, Choy H, Safran H, Sikov W, Rege V, Sam-bandam S, Wittels E. Weekly paclitaxel in patients withadvanced lung cancer: preliminary data from a phase IItrial. Semin Oncol 1997; 24(4 suppl 12):S12-10-S12-13.


BASIC RESEARCH

Deborah Britt, Ph.D.

• Examination of a Novel Protein, LYRIC, and ItsInvolvement in Prostate Tumor SuppressionMediated by the Cell Adhesion Molecule(CEACAM1-L), Department of Defense

• The Role of a Novel Protein, LYRIC in Developmentof Hepatocellular Carcinoma, Lifespan (COBRE PilotProject)

Loren Fast, Ph.D.

• The Effect of INACTINE on Lymphocyte Response, V.I. Technologies, Incorporated (VITEX)

• Immunological Consequences of Transfusion, NIH/National Heart Lung & Blood Institute

• Induction of Anti-Tumor Immunity Using CD4+ TCells as Antigen-Presenting Cells, Rhode IslandCancer Council, Incorporated

Douglas Hixson, Ph.D.

• COBRE-The Role of Mitochondrial UncouplingProtein-2 (UCP2) in Colon Carcinogenesis, NIH/National Center for Research Resources

• Center for Cancer Research Development (COBRE)Proteomics, NIH/National Center for ResearchResources

• Center for Cancer Research Development (COBRE)Administrative, NIH/National Center for ResearchResources

• Molecular Determinants of MulticellularOrganization, NIH/National Cancer Institute

• Cellular Origins of Liver CancerGenesis of LiverCarcinomas With Oval Cell Traits, NIH/NationalCancer Institute

• FACTOR VIII12th International CEA Symposium,Octapharma Pharmaceutical , NIH/National CancerInstitutue

Yow-Pin Lim, M.D., Ph.D.

• Therapeutic and Prognastic Application of HumanPlasma Inter/alpha Inhibitor in the Management ofSepsis, The Slater Center for Biomedical Technology

• Immunoregulajtory Role of Granzyme in Sepsis,Lifespan

Andrew Makarovsky, Ph.D.

• Effect of Taxotere/Estramustine on the Phenotype ofAggressive Prostate Cancer Cell, AventisPharmaceuticals Products, Incorporated

Alan Rosmarin, M.D.

• Center for Genetics and Genomics, NIH/NationalInstitutes of Health/Brown

Nancy Thompson, Ph.D.

• Director, Pathobiology Graduate Program, BrownUniversity

• Amino Acid Regulated Gene Expression in Tumori-genesis, American Institute for Cancer Research

• Expression & Role of TA1, Oncofetal Gene in LiverCancer, NIH/National Cancer Institute

CLINICAL RESEARCH

James Butera, M.D.

• Phase III Study of ST1571 vs Interferon-a Combinedwith Cytarabine in Patients with Newly DiagnosedCancer, Novartis Pharmaceuticals Corporation

Anita Kestin, M.D.

• Prevent Study, Brigham & Women’s Hospital

Louis Leone, M.D.

• Cancer and Leukemia Group B Foundation, Cancerand Leukemia Group B Foundation

Anthony Mega, M.D.

• BrUOG NHL-83(Amgen) A Phase I Study ofEscalating Doses of Gemcitabine Combined withStandard CHOP Chemotherapy with G-CSF Support(G-CHOP-G) in Patients with Intermediate/highGrade or Mantle Cell NHL, Amgen

• LS-P-RE-107 Interleukin-2 in an Alternative Dose(The ILIAD Trial) Treatment of Patients withMetastatic Renal Cell Carcinoma with Low-DoseProleukin, Chirion

• BrUOG Pros-90 A Phase I/II Study of Taxol,Carboplatin and Colchicine (TCC) in AndrogenIndependent Prostate Cancer, Bristol Myers Squibb


Total Basic Research Expenses Academic Year 2002 $1,030,201 $454,219 $1,484,420

Academic Year 2003 $1,514,861 $430,300 $1,945,161


Academic Year 2003 $371,289 $89,624 $460,913


• BrUOG NHL-83(Eli Lilly) A Phase IStudy ofEscalating Doses of Gemcitabine Combined withStandard CHOP Chemotherapy with G-CSF Support(G-CHOP-G) in Patients with Intermediate/highGrade or Mantle Cell NHL

• A Randomized, Multicenter, Phase II Evaluation ofOntak in Patients with Previously Treated, Indolent, B-Cell, Non-Hodgkin’s Lymphoma, Ligand

Neal Ready, M.D.

• Comparison of Strontium and Samarium Uptake andRetention in a Murine Model for Bone Metastasis,Amersham Corporation

• A Phase I Multicenter Study of Continuous OralAdministration of SCH 66336 and IV Paclitaxel inPati, Schering-Plough Research Institute

• A Phase III Randomized Trial of Active Immuno-therapy with a Polyvalent Melanoma Vaccine (C-VAX)Versus Biotherapy with Interferon x-2b as a Post-Surgical Treatment for Stage III Melanoma, BrownUniversity

• A Phase III Randomized Double Blind Trial ofImmunotherapy with Polyvalent Melanoma Vaccine(C-VAX) Plus BCG vs Placebo Plus BCG as a PostSurgical Treatment for Stage IV Melanoma, BrownUniversity

• BRUOG PA-77 Herceptin and Gemcitabine forMetastatic Pancreatic Cancer That OverexpressesHER-2NEU, Brown University

• BrUOG PA-A-128 A Phase III Double Blind PlaceboControlled Trial of Gemcitabine Plus Placebo VersusGemcitabine Plus R115777 in Patients With AdvancedPancreatic Cancer, Brown University

• BRUOG ESO-78 A Phase I/II Trial of Herceptin,Paclitaxel, Cisplatin and Radiation Followed byMaintenance Herceptin for Adenocarcinomas of theEsophagus, Brown University

• A Randomized Double Blind Phase III ComparativeTrial of 2 Doses of ZD1839 (IRESSA) In CombinationW, Covance, Incorporated

• Sunbelt Melanoma Trial: A Multicenter Trial ofAdjuvant Interferon Alfa-2B for Melanoma Patientswith Early Lymph Node Metastasis Detected byLymphacic Mapping and Sentinel Lymph NodeBiopsy, Schering-Plough Corporation

• A Two Part Multiple Dose Clinical Trial of Safety andEfficacy of ABX-EGF in Combination with Paclitaxeland Carboplatin in Patients with Advanced Non-SmallCell Lung Cancer (LS-P-LU-303), Amgen,Incorporated

• A Phase I/II Study of Estramustine, Docetaxel andIfosfamide with Carboplatin in recurrent or MetastaticHead and Neck Squamous Cell Cancers (HN-SCC),Aventis Pharmaceuticals Products, Incorporated

• A Phase 3 Randomized Study of Lonafarbin inCombination with Paclitaxel and Carboplatin vs.Placebo in Combination with Paclitaxel andCarboplatin in Patients with Non-Small Cell LungCancer, Schering-Plough Corporation

• Sigma-Tau-ST 01-401 Phase I Study of Oral St 1481Administered Once Weekly Every 3 Out of 4 Weeks inPatients With Advanced Solid Malignancies, Sigma-Tau Pharmaceuticals Incorporated

• BrUOG H & N 86 Induction Chemotherapy withWeekly Taxol, Ifosfamide, and Carboplatin Followedby Concurrent Weekly Taxol and Carboplatin andRadiotherapy in Locally Advanced Head and NeckCancers, Bristol-Myers Squibb, Incorporated

• A Phase III Randomized Trial of Active Immuno-therapy with a Polyvalent Melanoma Vaccine (C-VAX) Versus Biotherapy with Interferon x-2b as aPost-Surgical Treatment for Stage III Melanoma,Brown University/NCI/John Wayne Cancer Institute

• Phase II Study of Weekly Gemcitabine and Paclitaxelfor Advanced Non-Small Cell Carcinoma of the Lung(Eli Lilly & Co), Eli Lilly and Company

• Outpatient Concurrent Chemo-Biotherapy forMetastic Malignant Melanoma Phase II, ChironCorporation

• Outpatient Concurrent Chemo-Biotherapy forMetastatic Malignant Melanoma, Phase II, ScheringCorporation

• The SILVA Study: Survival in International Phase IIIProspective Randomized LD Small Cell Lung CancerVaccination Study with Adjuvant BEC2 and BCG ,Imclone Systems Incorporated

• A Multicenter, Open Label Randomized Study ofThree Schedules of Weekly Taxol Induction TherapyFollowed by Weekly Taxol Maintenance Therapy inMetastatic Breast Cancer Patients, Theradex

Alan Rosmarin, M.D.

• BrUOG MDS-85 Phase I/II Study of ONTAK in theTreatment of Myelodysplastic Syndromes, BrownUniversity

• An Open-label, Randomized Study to Develop aScreening Tool for Functional Capacity in AnemicSubjects with Nonmyeloid Malignancies ReceivingChemotherapy with Darbepoetin also (NESP),Amgen


Howard Safran, M.D.

• BrUOG ESO-78 A Phase I/II Trial of Herceptin,Paclitaxel, Cisplatin and Radiation Followed byMaintenance Herceptin for Adenocarcinomas of theEsophagus, Genentech Inc./Brown University

• Ls-P-PA103 Randomized Phase II Trial to Evaluatethe Effect of Gemcitabine Plus R115777 VersusGemcitabine Plus Placebo on Time to Deteriorationin Patients with Advanced Pancreatic Cancer(R115777-INT-16), PRA/Janssen

• BrUOG PA-77 Herceptin and Gemicitabine forMetastic Pancreatic Cancers that Overexpress HER-2/neu, Brown University

• BrUOG LU-A-117 The Silva Study-Survival in anInternational Phase III Prospective Randomized LDSmall Cell Lung Cancer Vaccination Study withAdjuvant BEC2 and BCG (EORTC Protocol 08971),Brown University

• BrUOG LU-A-109 A Phase III, Multi-Center,Randomized, Double-Blind, Placebo-ControlledStudy Marimastat in Patients with Minimal DiseaseStage III Non-Small Cell Lung Cancer (CO3/IVB/173), Brown University

• BrUOG PA-77 Phase II Study of Herceptin andGemcitabine For Metastatic Pancreatic Cancers ThatOverexpress HER-2/Neu, Lilly Research/BrownUniversity

• BrUOG PA-A-128 Phase III, Couble-Blind, PlaceboControlled Trial of Gemcitabine vs. R115777 PlusGemcitabine in Patients With Advanced PancreaticCancer, Janssen Pharm./Brown University

• Herceptin and Gemcitabine for Metastatic PancreaticCancers That Overexpress Her2/NEU (Genentech),Genentech, Incorporated

• R115777-INT-11, A Phase III, Double-blind, Placebo-Controlled Trial of Gemcitabine Plus Placebo VersusGemcitabine Plus Placebo versus Gemcitabine plusR115777 in Subjects with Advanced PancreaticCancer, Janssen

• LS-P-GA101 “A Phase II Study of Epothilone AnalogBMS-247550 in patients with Metastatic GastricAdenocarcinoma Previously Treated with a Taxane,Bristol Myers Squibb

• LS-P-PA-109 A Randomized, Open-Label, Multi-center Phase III Study Comparing the Efficacy andSafety of a Combination of Intravenous DX-8951F(exatecan mesylate) plus Gemcitabine to GemcitabineAlone in Patients with Locally Advanced orMetastatic Cancer, Daiidhi Pharmaceutical

• Phase I/II Study of Capecitabine/Taxotere andCarboplatin in Metastatic Adenocarcinoma of theEsophagus and Stomach, Aventis PharmaceuticalsProducts, Incorporated

• Percutaneous Radiofrequency Ablation of BoneMetastasis Using CT Guidance, RadionicsInstruments/Brown University

• Radiation Therapy Oncology Group (RTOG), NIH/Brown University

• A Phase II Study to Determine the Antitumor Activityof Farnesyltransferase Inhibitor R115777 in Subjectswith Relapse Small Cell Lung Cancer, JannsenPharmaceuticals/Brown University

• A Double-blind, Placebo Controlled, MinimizedPhase III Study Comparing Marimastat to Placebo asAdjuvant Therpay in Patients with RespectablePancreatic Cancer, Brown University

• Phase II Study of TLC D-99 for HepatobiliaryCarcinomas, Liposome/Brown University

• A Compassionate Use Study of Oxaliplatin forPreviously Treated Colorectal Cancer Patients,Jansenn Pharmaceuticals/Brown University

• A Phase I Trial of Tarceva, Gemcitabine, Paclitaxel,and Radiation for Locally Advanced PancreaticCancer, Genentech, Incorporated

• An Open-Label, Phase I Study to Evaluate the Saferyand Tolerability of rV-CEA(6d)Tricom Admixed WithrV-MUC-1 followed by rV-CEA(6D)/Tricom inCombination With GM-CSF in Subjects withUnresectable Adenocarcinoma of the Pancreas,Therion Pharmaceuticals

• Safety and Efficacy of Oral Gimatecan (ST 1481)Administered on a dx5 Schedule Every 28 Days asSecond Line Therapy for Metastatic ColorectalCancer in Patients without Previous Exposure toCamptothecins (A Phase II Trial), Sigma-TauPharmaceuticals Incorporated

William Sikov, M.D.

• Cancer and Leukemia Group B, NIH/National CancerInstitute, ,

• CALGB Foundation Grant, NIH/National Institutesof Health/University of Chicago

• BrUOG LU-76 Phase II Study of Weekly Gemcitabineand Paclitaxel for Advanced NSCL, Brown University

• A Phase II Study of Glutamine Supplementation inPatients Receiving Weekly Taxol for Metastic Breaston Non-Small Cell Lung Cancers, Bristol-MyersSquibb/BU

• A Randomized Multicenter, Phase II Study of Bolus/Infusion 5FU/LV vs Oxaliplatin and Bolus Infusion 5-FU/LV as Third-Line Treatment of Patients withMetastatic Colorectal Carcinoma EFC 4760, PrologueResearch

• BMS CA 163-012-010 A Phase II Study of Epotheloneanalog BMS-247550 in Patients with MetastaticColorectal Cancer Previously Treated with aFluorphyrimidie and Irinotecan, Bristol MyersSquibb

• A Multicenter, Open-label, Randomized, Two-armStudy of Irinotecan (CPT-11) versus the combinationof Oxaliplatin and Irinotecan (CPT-11) as SecondLine Treatment of Metastatic Colorectal Carcinoma,Sanofi-Synthelabo


• Gemcitabine and Capectibine in Advanced BreastCancer: A BrUOG Phase II Study, Roche Laboratories

• A Randomized, Open Label, Multicenter Study ofPrimary Prophylaxis with Neulasta Versus SecondaryProphylaxis as and Adjunct to Chemotherapy inElderly Subjects with Cancer, Amgen, Incorporated

• A Multicenter, Open-label, Randomized Study ofThree Schedules of Weekly Taxol Induction TherapyFollowed by Weekly Taxol Maintenance Therapy InMetastatic Breast Cancer Patients, Brown University

• Phase I Study of Weekly Docetaxel and Doxorubicinin Advance Cancers, Brown University

• Phase I Study of Weekly Docetaxel and LipsomalDoxorubicin HCI (Doxil) in Advanced Cancers,Brown University

• An Open-Label, Multicenter, Randomized, Phase IIIcomparator Study of Oral Topotecan VersusIntravenous Topotecan for Second-Line Therapy inPatients with SCLC Who Have Relapsed Greater thanor equal to 90 Days After Completion of First LineTherapy, SmithKline Beecham/Brown University

• Multicenter Phase II Study of Herceptin andNavelbine as First-Line Therapy for HER2-positive.Metastatic Breast Cancer, Dana Farber/GLAXO

• Gemcitabine and Capectibine in Advanced BreastCancer: A BrUOG Phase II Study, Lilly Research/Brown University

Rochelle Strenger, M.D.

• NSABP Breast Cancer Prevention Trial, NIH/NationalInstitutes of Health/Dana Farber Cancer Inst.

I N F E C T I O U S D I S E A S E

Timothy P. Flanigan, M.D., Associate Professor of Medicine; Director,

Division of Infectious Disease

Overview

The Division has continued to grow and develop

new initiatives in the area of HIV and AIDS,

bioterrorism, and inpatient infectious diseases. The

Lifespan/Tufts/Brown Center for AIDS Research,

under the leadership of Dr. Charles Carpenter, has

been renewed by the NIH for a five-year period, 2002

through 2007, with a total budget of $7.9 million

dollars. This grant reflects the continuing outstanding

clinical, basic and translational research carried out by

the Brown and Tufts University faculties, and

recognizes that the total external HIV/AIDS research

funding, from all sources, for Brown University faculty

during FY-2002, exceeded $10,000,000 per annum.

The NIH Center grant strongly supports the primary

thematic goal of the Lifespan/Tufts/Brown CFAR,

which is to carry out translational research which deals

especially with the treatment and prevention of HIV

infection in hard-to-reach populations, both in New

INFECTIOUS DISEASEEngland and in several

countries in the developing

world.

The new AIDS Clinical Trials

Unit (ACTU) at The Miriam

Hospital/Brown University,

under the leadership of Dr.

Karen Tashima and Dr.

Timothy P. Flanigan, has been

an outstanding success. This is

one of 30 units around the

country which is NIH funded

to participate in multi-center

HIV and AIDS treatment trials.

The Miriam Hospital/Brown

University has played a leading

role in the development and

enrollment of HIV treatment

trials, specifically for women.

Dr. Susan Cu-Uvin has been

elected as Vice Chair of the

Women’s Group of the AIDS

Clinical Trials Group (ACTG).

We have been chosen as one of

six sites to develop a new

international treatment

initiative for HIV and AIDS as

part of the ACTG. We have

developed a multi-center

treatment protocol which will be implemented in

Chennai, India with our collaborative partners at YRG

Care.

A new Center for Biodefense at Memorial Hospital

under the leadership of Dr. Andy Artenstein has been

one of the key successes of this year. Dr. Artenstein has

played a leading role, in collaboration with Dr. Peggy

Neill at Memorial Hospital in community based educa-

tion around biodefense since 9/11. The Center has been

awarded a substantial contract from the Rhode Island

Department of Health to establish educational and

dissemination tools for the health care community, as

well as for the broader public. Under the leadership of

Dr. Artenstein, Memorial Hospital will participate in

Phase I/II trials to evaluate the safety and efficacy of

new more effective smallpox vaccines. Dr. Peggy Neill

was asked to chair the Bioterrorism Working Group for

the Infectious Disease Society of America, which has


played a leading role in education of Infectious

Disease physicians since 9/11.

Within the last year, the Rhode Island State Tubercu-

losis Treatment Program moved to The Miriam

Hospital , Brown University School of Medicine. This

has been a nationally recognized program of excel-

lence which was cited by the Centers for Disease

Control for its leadership nationwide in establishing

directly observed therapy programs for all persons

with TB. This program has participated in national

trials to improve TB therapy. Dr. Jane Carter has

established a outstanding collaboration with Moi

University Medical School in Eldoret, Kenya, which

will investigate improved TB therapeutic strategies for

patients who have TB alone and for those patients

who are co-infected with HIV and TB in the

developing world, which poses unique challenges.

The Division of Infectious Diseases has played a lead

role in defining improved strategies to prevent noso-

comial infections particularly related to intravenous

catheters. Intravenous catheter infections are a major

cause of morbidity among inpatients. Dr. Len Mermel

has spearheaded efforts to better define and institute

prevention strategies. These efforts were published in

a lead article in the Annals of Internal Medicine

(Prevention of Intravascular Catheter Related

Infection”). He has served on committees to develop

these guidelines for the Society of Critical Care

Medicine, The Infectious Disease Society of America,

the Society for Health Care Epidemiology of America,

and Hospital Infection Control Advisory Committee

to the Centers for Disease Control and Prevention.

The Division of Infectious Diseases has established a

new inpatient consultative service to prevent and treat

infections among patients who receive solid organ

transplants, particularly kidney transplants. In the last

year, Rhode Island Hospital performed more kidney

transplants than any other hospital in New England.

The Division, under the leadership of Staci Fischer,

M.D. has established a inpatient consultative service

and an outpatient Infectious Disease Clinic in order to

provide care for this group of vulnerable patients.

Over the course of the last year, The Miriam Hospital

has participated in international HIV vaccine

prevention trials under the sponsorship of the NIH in

collaboration with Harvard University and under the

sponsorship of Merck Pharmaceuticals. Doctors

Michelle Lally and Ken Mayer have developed a team

which has participated in over six different multi-

center national trials to evaluate HIV vaccine

strategies. Many of these trials have utilized the new

Merck HIV vaccine candidate which uses an adeno-

virus to immunize individuals with HIV related

antigens. The ultimate goal is that these vaccines will

be utilized to prevent HIV worldwide and to boost the

immune response to HIV among individuals who are

already infected. This type of strategy is called

therapeutic vaccination, and holds great promise for

the one million people nationwide who are already

infected with HIV.

Dr. Ken Mayer received multiple awards for his out-

standing work in 2001 in the area of HIV prevention.

He was honored by the American Federation for AIDS

Research to receive its yearly award for leadership in

the area of HIV clinical research. He was chosen as the

Paul Galkin Lecturer for Distinguished Leadership in

HIV and AIDS. He also received honorary lifetime

membership in the Indian Medical Association due to

the establishment of the HIV/AIDS prevention and

treatment collaboration with YRG Care in Chennai,

India. Dr. Mayer leads the HIV Prevention Trials

Network program at The Miriam Hospital/Brown

University, which has played a leading role in

developing and evaluating microbicides for the

prevention of HIV, both in this country and in

resource poor settings.

Dr. Timothy P. Flanigan and Dr. Jennifer A. Mitty have

spearheaded a program of directly observed therapy

for HIV treatment for individuals who are

marginalized and would otherwise not receive the

benefit of our new combination HIV treatments. A

pilot program for active substance abusers to provide

community based treatment strategies is ongoing and

has been cited nationally. This work has been pre-

sented at the Infectious Disease Society of America,

the Conference on New Advances in HIV Therapies

sponsored by the American Federation for AIDS

Research, and the National Retroviral Conference, and

has received funding through an RO1 from the

National Institutes of Health. Pilot programs to extend

these community based therapies for pregnant women

and persons leaving prison have begun.

Bharat Ramratnam, M.D. directs the Virology Core

laboratory at Brown for the Center for AIDS Research.

His work investigates viral dynamics, and particularly

viral decay among individuals who are long term

injection drug users. This year he received funding

from the Doris Duke Foundation, NIH/NIAID, and

the Culpepper Foundation.


INTERNATIONAL WORK

Jane Carter, who is a national expert on TB, oversees

residential opportunities for clinical research in Africa

(Moi Medical School, Kenya) and in Southeast Asia

(Chennai, India, Cambodia, Philippines and Indo-

nesia) related to HIV prevention and treatment of

AIDS and opportunistic infections. Herb Harwell,

M.D., who was trained in both Pediatrics and Medi-

cine, has expertise in the area of sexually transmitted

diseases and HIV. He has developed ongoing projects

in Phnom Penh, Cambodia to evaluate the long term

morbidity and mortality related to HIV and the

potential impact of antiretroviral therapy in Southeast

Asia.


Timothy P. Flanigan, M.D., Director, Associate Professor,Miriam Hospital, University Medicine Foundation

Andrew W. Artenstein, M.D., Associate Professor TST,Memorial Hospital of RI

Daniel Boden, M.D., Assistant Professor (Res.), RhodeIsland Hospital

Charles C. J. Carpenter, M.D., Professor, MiriamHospital, University Medicine Foundation

*E. Jane Carter, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Wendy Clough, M.D., Clinical Associate Professor,Rhode Island Hospital, University MedicineFoundation

Ruth I. Connor, Ph.D., Assistant Professor (Res.),Miriam Hospital

*Susan Cu-Uvin, M.D., Associate Professor, MiriamHospital, University Medicine Foundation

Staci A. Fischer, M.D., Assistant Professor, Rhode IslandHospital, University Medicine Foundation

Mary Flynn, Ph.D., Assistant Professor, Miriam Hospital

Melissa Gaitanis, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Stephen Gregory, Ph.D., Associate Professor, RhodeIsland Hospital

Joseph I. Harwell, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Awewura Kwara, M.D., Clinical Instructor, MiriamHospital, University Medicine Foundation

Michelle Lally, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

John Lonks, M.D., Assistant Professor, Miriam Hospital,University Medicine Foundation

Mark Lurie, Ph.D., Assistant Professor, Miriam Hospital

Kenneth Mayer, M.D., Professor, Miriam Hospital,University Medicine Foundation

Antone Medeiros, M.D., Professor, Miriam Hospital,University Medicine Foundation

Leonard A. Mermel, D.O., Associate Professor, RhodeIsland Hospital, University Medicine Foundation

Maria Mileno, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Jennifer Mitty, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Michael C. Newstein, M.D., Ph.D., Assistant Professor(Res.), Miriam Hospital

Marguerite Neill, M.D., Associate Professor, MemorialHospital of Rhode Island

Steven Opal, M.D., Professor, Memorial Hospital ofRhode Island

Oliver Pusch, Ph.D., Assistant Professor (Res.), RhodeIsland Hospital

Bharat Ramratnam, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Josiah Rich, M.D., M.P.H., Associate Professor, MiriamHospital, University Medicine Foundation

Karen Tashima, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Lynn Taylor, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Edward J. Wing, M.D., Professor, Chairman of Medicine,Physician-in-Chief, Rhode Island Hospital, TheMiriam Hospital University Medicine Foundation

VOLUNTEER FACULTY

Rinchen-Tzo Emgushov, M.D., Clinical Instructor,Rhode Island Hospital

Alvan Fisher, M.D., Clinical Associate Professor, RhodeIsland Hospital

Glenn Fort, M.D., Clinical Associate Professor, MemorialHospital of Rhode Island

Merik Spiers Gross, M.D., Clinical Instructor, MiriamHospital

Dennis Mikolich, M.D., Clinical Associate Professor,Veterans’ Administration Medical Center

ADJUNCT FACULTY

Seth Berkley, M.D., Adjunct Associate Professor, MiriamHospital

Pamina Gorbach, M.H.S., Dr.P.H., Adjunct AssistantProfessor, Miriam Hospital

Peter Herbert, M.D., Adjunct Professor, Miriam Hospital



Andrew W. Artenstein, M.D., F.A.C.P.Invited Presentations:

• From September 2001 through June 2002, Dr.Artenstein presented “Biological Warfare, Bio-terrorism and Defense” to 35 state and nationalgroups, including: Brown University InfectiousDiseases Conference, Newport Hospital, Newport, RI;Fatima Hospital, Providence, RI; St. Luke’s Hospital,New Bedford, MA; The Westerly Hospital, Westerly,RI; South County Hospital, Wakefield, RI; RhodeIsland Hospital; Roger Williams Medical Center,Providence, RI; Memorial Hospital of Rhode Island;Charlton Memorial Hospital, Fall River, MA; TheMiriam Hospital, Providence, RI; Milford-Whitins-ville Hospital, Milford, MA; Women & InfantsHospital of Rhode Island; Mount Auburn Hospital,Cambridge, MA; and U.S. Naval Reserves, Newport,RI. He participated in multiple forums on


Name New Position

Anne Spaulding, M.D. Clinical Assistant Professor, Rhode Island Hospital

New Faculty

Name Former Position New Position

Daniel Boden, M.D. Research Fellow, Aaron Diamond AIDS Research Ctr. Assistant Prof. (Res.)

E. Jane Carter, M.D. Transfer from Clinical track to FT track Assistant Professorat Brown Medical School

Ruth I. Connor, Ph.D. Assistant Professor, The Rockefeller University Assistant Prof. (Res.)

Awewura Kwara, M.D. Fellow, Tulane University School of Medicine Clinical Instructor

Mark Lurie, Ph.D. Research Fellow, Brown University Assistant Professor

Melissa Murphy, M.D. Fellow, Tufts University Medical School/NEMC Assistant Professor

Michael C. Newstein, Graduate Assistant, Harvard Medical School Assistant Prof. (Res.)M.D., Ph.D.

Oliver Pusch, Ph.D. Assistant Professor, University of Vienna Assistant Prof. (Res.)

Bharat Ramratnam, M.D. Fellow, The Rockefeller University, Assistant ProfessorAaron Diamond AIDS Research Center

Alan S. Katz, M.D., Adjunct Associate Professor, RhodeIsland Hospital

G. Richard Olds, M.D., Adjunct Professor, MiriamHospital

Renee Ridzon, M.D., Adjunct Assistant Professor, RhodeIsland Hospital

Rodrigo Romulo, M.D., Adjunct Assistant Professor(Research), Miriam Hospital

Harry Schrager, M.D., Adjunct Assistant Professor,Veterans’ Administration Medical Center

Gail Skowron, M.D., Adjunct Associate Professor, RogerWilliams Medical Center

Stephen Zinner, M.D., Adjunct Professor, Rhode IslandHospital

*Faculty with secondary appointments in Medicine


bioterrorism including “Doctors Speak onBioterrorism”, Channel 36, Providence, RI, October2001

• “Bioterrorism and the Public Response”, Rhode IslandDepartment of Health.

• “Viral Hemorrhagic Fevers: Emerging Threat?”,Washington Hospital Center, Washington D.C., May2002;

• “Biological Warfare, Bioterrorism, Defense andUniversal Precautions”, Butler Hospital, Providence,RI

Advisory Boards or Committees:

• Invited Consultant, Bioterrorism and Biodefense,Division of Infectious Diseases at WashingtonHospital Center

• Consultant for Bioterrorism and Chemical Weapons,Rhode Island Department of Health

• Hospital Emergency Preparedness Committee,Memorial Hospital of Rhode Island, Pawtucket,Rhode Island

• Co-chair, Brown Infectious Diseases Committee onBiological Defense and Emerging Pathogens (BDEPCommittee), Brown Medical School, Providence,Rhode Island

• Consultant on Biological Weapons, “ER One” Project,sponsored by Washington Hospital Center, the Officeof Emergency Preparedness, Washington DC,(Designing the Emergency Room of the next centurywhich will be capable of safely caring for patientswith biological and chemical warfare injuries)

• Medical Education Committee, Memorial Hospital ofRhode Island, Pawtucket, RI

• Bioterrorism Consultant, “Team Hope Exercise”,Statewide Terrorism Field Exercise, Rhode IslandDepartment of Health

Charles C. J. Carpenter, M.D.Invited Presentations:

• Discussed the new IAS-USA Recommendations forAntiretroviral Treatment Regimens, at a plenarysession of the 1st Conference on HIV Pathogenesisand Treatment in Buenos Aires, Argentina

• Gave the second annual E. Hunter Wilson Lectureentitled “AIDS:? The Major Pandemic of the 21st

Century in Baltimore, M.D.

• Received the Rhode Island Chapter, American Collegeof Physicians, American Society of Internal Medicine,Milton Hamolsky Lifetime Achievement Award fordistinguished contributions to the practice ofmedicine

• Served as the Alpha Omega Alpha Visiting Professorat the Ohio State University of Medicine and PublicHealth

• Served as rapporteur for the Institute of MedicineWorkshop titled Smallpox: The Scientific Basis forVaccination Policy Options

E. Jane Carter, M.D.• Member, Infection Control Committee, Miriam

Hospital

• Governor, American College of Chest Physicians,State of Rhode Island

• Secretary-Treasurer, North American Region of theInternational Union Against TB and Lung Disease

Awards:

• Dr. Sharon Zupko Award, Traveler’s Aid Society,Providence, Rhode Island


• American College of Physicians/American Society ofInternal Medicine – Rhode Island Chapter, InternalMedicine Update, Newport, Rhode Island, “Demys-tifying TB Infection: When to Screen. When to Treat”

• “TB Today and Tomorrow”, Woods Hole, Massachu-setts, Panel Discussion Participant, “Latent TBInfection – Controversies in Management”

• Rhode Island Academy of Family Physicians, PrimaryCare Update, Newport, Rhode Island, “TuberculosisUpdate – Screening and Treatment of Latent TBInfection”

• Regional TB Conference, Fall River, Massachusetts,Panel Discussion Participant, Case Vignettes (HIV/TBissues)

Susan Cu-Uvin, M.D.Invited Presentations:

• Focus on Women: Challenges in the Prevention andTreatment of HIV/AIDS, (Amfar), Gynecologic IssuesRelated to HIV/AIDS.

• Reproductive Choices for HIV-Infected Patients, NewYork, New York

• Virologic Factors in the Genital Tract and HIVVertical Transmission, New York, New York

• Course Director, Women at Risk: Primary Preventionof HIV and STDs for Women of Childbearing Age.Providence, Rhode Island

Staci A. Fischer, M.D.• Invited Member, Graduate Education Committee,


• Invited Member, Task Force on Teaching Rewards,Lifespan/Rhode Island Hospital System, Departmentof Medicine


• Pathophysiology Course, Brown Medical School,Providence, Rhode Island, Lecture: Central NervousSystem Infections


• Medical Microbiology Course, Brown MedicalSchool, Providence, Rhode Island, Lecture: MedicallyRelevant Fungi: the Clinical Perspective

• Department of Neurosurgery, Rhode Island Hospital,Providence, Rhode Island, Lecture: A Practical Guideto Antibiotic Usage for Neurosurgeons

• Infectious Disease Grand Rounds, Brown MedicalSchool, Providence, Rhode Island, Lecture: ViralInfections in the Transplant Population

• Noon Conference, Department of Medicine, BrownMedical School, Providence, Rhode Island, Lectures:Meningitis, Infectious Diseases, Sexually TransmittedDiseases.

• Multidisciplinary Group on Diabetes Care, RhodeIsland Hospital, Brown Medical School, Providence,Rhode Island, Lecture: Update on Antibiotics for Usein Diabetic Foot Infections

• Infectious Disease Fellowship Lecture Series, RhodeIsland Hospital, Providence, Rhode Island, LectureTopics: Transplant Infections, Infectious Diarrhea,Fungal Infections, Endocarditis, Sexually TransmittedDiseases

Timothy P. Flanigan, M.D.• Fellow, American College of Physicians

• Awards: Francesco Cannistra, M.D., Memorial Award.Thundermist Health Ctr. Woonsocket, RI. 2002.


• “ HIV Diagnosis, Care, and Prevention amongIncarcerated Persons: A Missed Opportunity”. HIVIssues Among the Incarcerated. 2001 National HIVPrevention Conference. Atlanta, GA

• “Update on HIV”. Grand Rounds, Women andInfants Hospital, Providence, Rhode Island

• Keynote speaker for Brown University Medical SchoolBiomedical Research Day, Providence, Rhode Island

• Moderator, “Antiretroviral Therapy AmongIncarcerated Persons”. Presenter: “Linkage toCommunity Care Among Incarcerated Persons”.Princeton, New Jersey

• “HIV Management in the Youthful Offender”. 9th

Annual Meeting of the Society of CorrectionalPhysicians. Nashville, TN. 2002.

• “A tale of Two Epidemics: What we can learn from theTB and Syphilis epidemics to fight the HIVpandemic”. Grand Rounds. Case Western ReserveUniversity, Cleveland, OH and Indiana UniversityGrand Rounds. 2002.

• Internal Medicine Update. Brown University MedicalSchool. “A Tale of Two Epidemics”. Providence, RI.2003.

• Rhode Island Academy of Family Physicians. “HIVUpdate”. Mystic, CT. 2003.

• Effectiveness Research on Antiretroviral Therapy inthe Developing World- Setting an Agenda for Action.“ART in Southern India”. Stony Point, NY. 2003.

Joseph I. Harwell, M.D., F.A.A.P.• Member, American Academy of Pediatrics (AAP),

Section on Infectious Diseases

• Member, American Academy of Pediatrics, Med/PedsSection


• “Spectrum of opportunistic infections inhospitalized, HIV-infected patients in Phnom Penh,Cambodia”. 6th International Congress on AIDS inAsia and the Pacific, Melbourne, Australia.

• “Chronic diarrhea in HIV-infected patients admittedto Norodom Sihanouk Hospital, Phnom Penh,Cambodia”. 6th International Congress on AIDS inAsia and the Pacific, Melbourne, Australia

• “Etiology of meningitis in HIV-infected inpatients inan urban hospital in Phnom Penh, Cambodia”. 6th

International Congress on AIDS in Asia and thePacific, Melbourne, Australia

• “Tuberculosis presenting as abdominal lymphadeno-pathy in patients infected with HIV in Phnom Penh,Cambodia”. International Union Against Tuberculosisand Lung Disease, North American Region Meeting,Vancouver, British Columbia

• “Factors Associated with HIV-1 RNA Shedding in theFemale Genital Tract: 24 Months Follow-up”. 9th

Conference on Retroviruses and OpportunisticInfections, Seattle, Washington

• “HIV-1 RNA Levels in the Female Genital Tract Differby Collection Method: Analysis of CervicovaginalLavage and Sno-Strip Collections”. 9th Conference onRetroviruses and Opportunistic Infections, Seattle,Washington

• “Sexual Risk Behaviors and Epidemic Hepatitis Bamong IDUs Receiving Prescriptions for Syringes”.2002 National STD Prevention Conference. SanDiego, California

• Medical Grand Rounds, “Central Nervous SystemInfection in HIV,” Sihanouk Hospital Center of Hope,Phnom Penh, Cambodia

• Medical Grand Rounds, “ExtrapulmonaryTuberculosis,” Sihanouk Hospital Center of Hope,Phnom Penh, Cambodia

• Biomed 282, Pathophysiology of Infectious Diseases,“The Herpesviruses,” Brown Medical School,Providence, Rhode Island

• Guest lecturer for BC 34, Health and HumanReproduction: “Sexually transmitted diseases in thedeveloping world.”


• “Ethical Issues in Research,” Sihanouk HospitalCenter of Hope Research Training Group, PhnomPenh, Cambodia

John R. Lonks, M.D.Presentations:

• Failure of macrolide treatment of erythromycin-resistant Streptococcus pneumoniae. Lonks JR, Garau J,Gomez L, Xercavins M, de Echaguen AO, MedeirosAA. Abstract L-1850. Abstracts of the 41stInterscience Conference on Antimicrobial Agents andChemotherapy. Chicago, Illinois. (oral presentation)

• Failure of macrolide treatment of erythromycin-resistant Streptococcus pneumoniae. Lonks JR, Garau J,Gomez L, Xercavins M, de Echaguen AO, MedeirosAA. Abstract 8.36. Program and Abstracts The SixthInternational Conference on the Macrolides, Azalides,Streptogramins, Ketolides and Oxazolidinones.Bologna, Italy. (poster and oral presentation)

Kenneth H. Mayer, M.D.• Honorary life membership of The Indian Medical

Association, Chennai Central Branch, India

Editorial Boards:

• AIDS Alert

• Medical Editor, AIDS/HIV Treatment Directory(published by American Foundation for AIDSResearch)

• Opportunistic Infections in HIV Infected Patients

• International Editorial Advisory Committee, Actuali-zaciones en Sida (Spanish language AIDS Journal)

• International Editorial Advisory Committee,Atualizacao em AIDS (Brazilian AIDS Journal)

• Editorial Advisory Board, Clinical Microbiology andInfection

• AIDS Patient Care and STDs

• Special Topics Editor HIV/AIDS, Clinical InfectiousDiseases


• Invited Speaker, “Prevention of HIV InfectionThrough STD Control and ART Intervention”,International AIDS Society, 1st Conference on HIVPathogenesis and Treatment, Buenos Aires, Argentina

• Invited Speaker, AmFar Conference on ExpandingClinical Research Capacity in Asia, Bangkok,Thailand

• Presentation, “Microbicides: Progress in the Develop-ment of a Novel Approach to the Prevention of HIV/STD”, presentation with Celentano DD, SrikrishnanAK, et al: HIV/STD burden in urban slums of SouthIndia. 6th International Conference on AIDS in Asiaand the Pacific, Melbourne, Australia

• Presentation, “Knowledge, attitudes and beliefsregarding HIV, and attitudinal and structural barriers

to care among South Indian physicians”, presentationwith Ganesh AK, Madhivanan, et al. 6th InternationalConference on AIDS in Asia and the Pacific,Melbourne, Australia

• Course Co-Director, Focus on Women, Challenges inthe Prevention and Treatment of HIV/AIDS, anAmFar continuing medical education symposium,New York, New York

• Invited Speaker, “When Should HIV Therapy be Initi-ated: A Response”, Conference to Develop HIV/AIDSTherapeutic Research Agenda for Resource-limitedCountries, sponsored by Infectious Diseases Society ofAmerican, UNAIDS, and NIH, San Francisco,California

• Convener and Moderator, “Cutting-Edge Issues inHIV Medicine”, 39th Annual Meeting of InfectiousDisease Society of American, San Francisco, California

• Panelist, AIDS and Rights, World AIDS DayConference, sponsored by Students for AIDSAwareness, Brown University, Providence, RhodeIsland

• HIV Clinical Conference: “Sexually TransmittedDiseases Among Local MSM: Past as Prologue?”,Center for AIDS Research Rounds, MassachusettsGeneral Hospital, Boston, Massachusetts

• Guest lecturer, “Diagnosis and Monitoring of HIVDiseases; Developing countries perspective”, IndianAssociationh of Medical Microbiologists, Chennai,India

• Guest lecturer, “Medical Approaches to HIVPrevention”, Update on HIV Diseases, Indian MedicalAssociation, Chennai, India

• Lecturer, “HIV Dynamics in the Genital Tract”,Lifespan/Tufts/Brown Center for AIDS Research, co-sponsored by Brown University AIDS Program,Providence, Rhode Island

• Co-Chair, 10th International Congress on InfectiousDiseases, Singapore. Session Chair, “Update onBiomedical Interventions to Prevent HIVTransmission”. Presenter, “The Use of AntiretroviralTherapy (ART) to Decrease HIV Transmission”

• Symposium Presenter, Biological Means forPreventing HIV Infection: “ART as Prevention”, 14th

National HIV/AIDS Update Conference, AmericanFoundation for AIDS Research, San Francisco,California

• Speaker, “Dealing with Side Effects”, Search for a Cure:HIV Treatment Community Forum, Boston,Massachusetts

• Speaker, “Biological Means to Prevent HIVTransmission: What Do We Know, and What Do WeHope?” Northern New England Infectious DiseaseSociety Annual Meeting, Waterville Valley, NewHampshire


• Invited Presenter, “HIV Transmission andPrevention”, 6th Annual HIV Update, Harvard MedicalSchool and Beth Israel Deaconess Medical Center,Boston, Massachusetts

Leonard A. Mermel, D.O., S.C.M., A.M.(Hon.), F.A.C.P., F.I.D.S.A.• Invited Moderator, Intravascular Catheter Associated

Infection Session, 41st Interscience Conference onAntimicrobial Agents and Chemotherapy, Chicago,Illinois

• Invited Moderator, Preventing Infections in the ICUSession, Society for Critical Care Medicine 31st

Annual Critical Care Congress, San Diego, California

• Invited Moderator, Device-Associated InfectionsSession, 12th Annual Scientific Meeting of the Societyfor Healthcare Epidemiology of America, Salt LakeCity, Utah

• Invited Member, Technical Expert Panel, MedicarePatient Safety Monitoring System, United StatesDepartment of Health and Human Services

• Invited Member, Guideline Committee on Preventionof Intravascular Catheter-Related Infections, Societyfor Critical Care Medicine, the Infectious DiseaseSociety of America, and the Hospital InfectionControl Advisory Committee to the Centers forDisease Control & Prevention

• Invited Advisor, Infectious Disease Society of AmericaCouncil

• Journal Advisory Board, Clinical Microbiology &Infection

Invited Oral presentations:

• International Conference-IV Therapy Home andHospital, Oxford Radcliffe Hospital Trust, Oxford,England. Lecture: Prevention of IntravascularCatheter-Related Infections

• Johns Hopkins University and University ofMaryland Fellowship Training Course, Baltimore,Maryland.

• Lecture: Epidemiology and Prevention BloodstreamInfection

• Interscience Conference on Antimicrobial Agents andChemotherapy. Chicago, Illinois. Lecture: Treatmentof Intravascular Catheter-Related Infections -Guidelines Based on Anecdotes, Wisdom or Facts

• Society of Critical Care Medicine Annual Meeting.San Diego, California. Lecture: Novel Devices toPrevent Catheter-Related Bloodstream Infections

• CDC, Council of State & Territorial Epidemiologists,Association of Public Health Laboratories, WHO andAmerican Society for Microbiology InternationalConference on Emerging Infectious Diseases. Atlanta,Georgia.

• Lecture: Prevention of Intravascular Catheter-RelatedInfections

• Washington University School of Medicine,Epidemiology 2002: An Update on HospitalEpidemiology. St. Louis, Missouri. Lecture:Epidemiology, Management and Prevention ofIntravascular Catheter-Related Infections: Fables,Foibles and National Guidelines

• National Institutes of Health (NIAID), InfectiousDiseases Grand Rounds, Bethesda, Maryland. Lecture:Pathogenesis and Prevention of IntravascularCatheter-Related Infections. NIAID Noon ConferenceLecture: Management of Intravascular Catheter-Related Infections, A Review of National Guidelines

• National Foundation of Infectious Diseases, Centersfor Disease Control & Prevention, US FDA, USDepartment of Agriculture Conference onAntimicrobial Resistance. Bethesda, Maryland.Lecture: Antimicrobial Impregnated Catheters:Clinical Impact and Theoretical Concerns?

• Rhode Island Hospital, Providence, Rhode Island.Surgical Grand Rounds: Treatment of IntravascularCatheter-Related Infections - Guidelines Based onAnecdotes, Wisdom or Facts

• Rhode Island Healthcare Engineers Society, RhodeIsland. Regulations for Infection Control Relating toConstruction. American College of Physicians AnnualMeeting of the Rhode Island Chapter, Warwick,Rhode Island. Panel Discussion: Bioterrorism &Chemical Warfare.

Marguerite A. Neill, M.D.• Chair, Bioterrorism Work Group , Infectious Disease

Society of America

• Chair, NIH Advisory Panel for Monoclonal AbTreatment of E. coli O157:H7 Infections

• Chair, Smallpox Task Group, for the InfectiousDisease Society of America

• Member, National Advisory Committee forMicrobiological Criteria in Foods

• Session Convenor, Foodborne and WaterborneDiseases II. 3rd International Conference on EmergingInfectious Diseases, Atlanta, Georgia

• Member, Steering Committee, 5th InternationalConference on Shiga toxin-producing E. coliInfections, (June 8-11, 2003), Edinburgh Scotland

• Editorial Board, Medicine and Health Rhode Island

Invited Talks/Presentations:

• “Infectious Diarrhea”, Internal Medicine Conference,Memorial Hospital of Rhode Island, Providence,Rhode Island

• “Pneumonia and Influenza”, Internal Medicine Confer-ence, Memorial Hospital of Rhode Island, Providence,RI


• “Anthrax: Issues and Update”, Family Medicine GrandRounds

• “Bioterrorism: Update and Resources”. InfectionControl Practioners of Southern New EnglandAnnual Meeting. Mansfield, Massachusetts

• “Anthrax: present problems and current advisories”.Primary Care Physician Advisory Committee, RhodeIsland Department of Health

“Bioterrorism and Physicians: Recognizing Disease,Responding to Fear”, Pediatric Grand Rounds, HasbroChildren’s Hospital, Providence, Rhode Island

• “Hepatitis A Update”. The American Society forMicrobiology and New England Association forClinical Microbiology and Infectious DiseaseMeeting. Seekonk, Massachusetts

• “The 3 Rs of Bioterrorism for Health Care Providers:Recognition, Response, Resources”. BiodefenseMobilization Conference, Seattle, Washington

• “Adult Immunizations”. Internal MedicineConference. Memorial Hospital of Rhode Island,Providence, RI

Steven M. Opal, M.D.Invited Presentations:

• Columbia University College of Physicians andSurgeons Grand Rounds. The Role of ActivatedProtein C and Other Endogenous Anticoagulants inthe Treatment of Sepsis

• 7th International Congress on PAF and LipidMediators. The potential role of PAF-acetylhydrolasein the prevention of ARDS, Tokyo, Japan

• Keio University Medical Grand Rounds. “Newtherapeutic Agents in the management of Sepsis”

• University of Colorado Health Sciences Center-IDgrand grounds. “Activated Protein C as a newtreatment for sepsis”

• Brooke Army Medical Center visiting professor-Medical Grand Rounds speaker. “Innovations in thetreatment of severe sepsis”, San Antonio, Texas

• Forth International Symposium of Sepsis in the ICU.“Mediators of sepsis”, London, UK

• Associate Editor-Web Site Manager, InfectiousDiseases (second edition). Section Editor, SpecialProblems in Infectious Disease Practice

• Editor, The Sepsis Text

• Editorial Board, Sepsis; Shock; Critical Care Medicine;Critical Care Forum; Advances in Sepsis

Josiah D. Rich, M.D., M.P.H.• James H. Nakano Citation, The National Center for

Infectious Diseases of the Center for Disease Controland Prevention, “for an outstanding scientific paperpublished in 2001”

• Section Editor, Journal of Urban Health

• Mentor, Brown University, Division of Biology andMedicine

• Board Member, Rhode Island Public HealthAssociation

• Editorial Board, Medical Editor, eMedicine’s Medicine,Surgery, OB/GYN and Psychiatry

• Editorial Board Member, HIV Inside (A QuarterlyNewsletter for Correctional Professionals)

• Member, Council of Healthcare Advisors


• “Physician Prescribing of Syringes to Prevent HIV”,2001 National HIV Prevention Conference (Abstract670), Atlanta, Georgia

• “Survey of Addiction Specialists: A Survey of SyringePrescription for HIV Prevention”, 2001 National HIVPrevention Conference (Abstract 894), Atlanta,Georgia

• “Prevalence of HIV and Hepatitis B and C amongInjection Drug Users in a Syringe PrescriptionProgram”, 2001 National HIV Prevention Conference(Abstract 623), Atlanta, Georgia

• “Physician Prescribing of Syringes to Prevent HIVand Hepatitis”, 2001 National HIV PreventionConference (Abstract 650), Atlanta, Georgia

• Invited Speaker: “HIV Prevention Strategies viaSyringe-exchange Programs,” Brigham & Women’sHospital, HIV Clinical Conference, Boston,Massachusetts

• Invited Speaker: “The Politics of HIV and InjectionDrug Use”, World AIDS Day Conference, Students forAIDS Awareness and the Brown Lecture Board,Brown Medical School, Providence, Rhode Island

• Invited Speaker: “Update on HIV,” Medical GrandRounds, Charlton Memorial Hospital, Fall River,Massachusetts

• Guest Lecturer: “Health Care in Prisons,” BrownMedical School, Providence, Rhode Island

Karen T. Tashima, M.D.• Honoree at “Annual Southeastern Massachusetts

Conference for those living with HIV/AIDS andthose who care for them”

• Elected Member, Complications of HIV DiseaseResearch Agenda Committee of the ACTG

• Member, Renal & Neurology Sub Committees of heACTG

Presentations:

• “Ambulatory Patient with HIV”, Didactic lecture, TheMiriam Hospital/Rhode Island Hospital PrimaryCare Resident Lecture Series


• “Approach to the Outpatient Management of an HIV-Infected Patient”, General Internal MedicineResidents at Rhode Island Hospital

• “New Antiretroviral Medications: Why and How toUse Them”, Brown University Infectious DiseaseConference

• “Metabolic and Morphologic Changes of HAART”,Lifespan/Tufts/Brown CFAR Seminar

• “HIV Update”, Lemuel Shattuck Hospital, JamaicaPlain, Massachusetts, Supported by Gilead Sciences,Inc.

• “New HIV Medications”, Thundermist Health Center,Woonsocket, Rhode Island

• “Clinical Case Discussions”, Primary Provider AIDSProgram, Brown University AIDS Program


Charles C. J. Carpenter, M.D.• Member of the Review Committee of the NIH/NIAID

on the Comprehensive International Program ofResearch on AIDS (CIPRA)

• Monitor of the Institute of Medicine ImmunizationSafety Review Committee Report on Thimerosal andNeurodevelopmental Outcomes

• Chair of the Review Committee of the NIH/NIAIDon the Comprehensive International Program onResearch on AIDS (CIPRA)

• Panel member: Guidelines for the Use of Antiretro-viral Agents in HIV-Infected Adults and Adolescents.Developed by the panel on Clinical Practices forTreatment of HIV Infection convened by theDepartment of Health and Human Services (DHHS)and the Henry J. Kaiser Foundation, July 14, 2003.

Susan Cu-Uvin, M.D.• Scientific Advisory Group Meeting, Global Microbicide

Project, Washington, D.C.

• Microbicide Research Planning Group, FY 2004,National Institute of Health, Washington, D.C.

• Planning Workshop on Women & Girls and HIV/AIDS Research, National Institute of Health,Washington, D.C.

• Forum for Collaborative HIV Research: Gender Issuesin the Management of HIV Care Prevention and Re-search. Planning Committee Member, Washington, D.C.

• Special Emphasis Panel. Microbicide Program ProjectReview. NIH

• Vice-Chair, Adult AIDS Clinical Trials Group,Women’s Health Committee

Timothy P. Flanigan, M.D.• Team Leader, Section on Cyroptosporidiosis and

Microsporidiosis, Section on Bacterial Infections forOpportunistic Infections Treatment Guidelines. Panelconvened by the CDC and NIH

• Executive Committee, Fogarty Program, InternationalHealth Institute, Brown University

• Associate Director, Brown University AIDS Program

• Reviewer, NIH/NIAID Topical Microbicides ProgramProject Reverse Site Visit. Washington, DC

• Invited presenter, Forum for Collaborative HIVResearch (DOT)

• Member, DSMB, NIH/NIMH RO1 Project,Washington, DC

Joseph I. Harwell, M.D., F.A.A.P.• Executive Committee, Brown University Fogarty

AIDS International Training and Research Program

Kenneth H. Mayer, M.D.• Medical Advisory Committee, Rhode Island Project

AIDS

• Scientific Advisory Committee, American Foundationfor AIDS Research

• Member, Epidemiology and Technology TransferSubcommittee of the AIDS Research ReviewCommittee (Study Section), NIAID

• International Scientific Committee, 2nd, 3rd, 4th, and 5th

International Conference on the Prevention ofInfection; (Nice, France 1992, 1994, 1996, 1998)

• National Board, American Foundation for AIDSResearch Chair, Treatment Information ServicesSubcommittee

• Co-Chair: Clinical Research Committee

• Clinical Advisory Panel, Cost-Effectiveness ofPreventing AIDS Complications (CEPAC), (NIHRO1: K. Freedberg, PI), Boston University School ofMedicine/Harvard Medical School

• AIDS Committee, Infectious Disease Society ofAmerica; Steering committee, HIV MedicineAssociation

• National Board of Directors, HIV MedicineAssociation of the Infectious Disease Society ofAmerica

• International Organizing Committee, Microbicides2002, International Conference, Antwerp, Belgium

• Scientific Advisory Committee, XIIIth InternationalConference on AIDS, Barcelona, Spain


• Board of Directors, New England Chapter, AmericanAcademy of HIV Medicine

• Planning Committee Member, 2003 National HIV Pre-vention Conference, Atlanta, Georgia (July 27-30, 2003)

Marguerite A. Neill, M.D.• Scientific advisor, ILSI North America Technical

Committee on Food Microbiology, ILSI Risk ScienceInstitute Steering Committee on the Problem ofListeria monocytogenes in Foods, Washington, DC

Steven M. Opal, M.D.• Data and Safety Monitoring Board:

Chairperson, Soluble Phospholipase A2 Inhibitor inSepsis-Lilly phase II trial

Chairperson, E5564 anti-endotoxin sepsis trial-Eisaiphase II clinical trial

Chairperson, Activated Protein C in sepsis with lowrisk of mortality phase III trial

Scientific Organizing Committee:

• The 3rd Margaux Conference in Critical Illness,Program Organizing Committee, Phoenix, Arizona

• The 7th Conference of the International EndotoxinSociety 2002, Program Organizing Committee,Immunology Section, Washington DC (July 18-21,2002)

• The 6th International Congress on the ImmuneConsequences of Trauma, Shock and Sepsis, ProgramOrganizing Committee, Munich, Germany, (March 7-11, 2004)

• Co-chairperson, International Steering Committee forSepsis Clinical Trials

• Member, Steering Committee FDA Meta-analysisCommittee on Sepsis

• Member, International Endotoxin Society – ProgramCommittee – Immunology

Josiah D. Rich, M.D., MPH• Advisory Board Consultant, GlaxoSmithKline

• Advisory Board Member, Roche Laboratories, Inc.

• Member, HIVQUAL Title III Project Clinical AdvisoryCommittee, NYSDOH AIDS Institute, Office of theMedical Director

• Consultant, Advisory Teleconference, C. Beck, LLC,“Evaluating an Option for First PI Treatment in YourHIV/AIDS Patients”

• Consultant, Bristol-Myers Squibb Company

• Research Committee, Tenth Annual Senior Residents’Research Day, Brown Medical School

TEACHING ACTIVITIES

EDUCATION HONORS

Andrew W. Artenstein, M.D., F.A.C.P.• Dean’s Teaching Excellence Award, presented by


Charles C. J. Carpenter, M.D.• Received the Distinguished Alumnus Award for

Excellence in Career from the class of 1952 at thePrinceton University

E. Jane Carter, M.D.• Chairman’s Award for Outstanding Teaching, Brown

University

• Excellence in Teaching Award for Clinical Faculty,Brown University

• Dean’s Teaching Excellence Award, Brown University

Staci A. Fischer, M.D.• Recipient, Dean’s Award for Excellence in Teaching,


Timothy P. Flanigan, M.D.• 2003 Profiles in Competence Award for Ability III

“Using Basic Science in the Practice of Medicine”.Awarded by 3rd and 4th Year Brown Medical SchoolStudents.

Joseph I. Harwell, M.D., F.A.A.P.• Dean’s Teaching Excellence Award, Brown Medical

School, Bio 282 Pathophysiology – Infectious Disease

Michelle A. Lally, M.D., MSc• Preceptorship Award: “An outstanding teacher in

medicine”, Rhode Island Hospital, The MiriamHospital, and Brown University

John R. Lonks, M.D.• Dean’s Teaching Excellence Award, Brown Medical

School, Course Bio 282

Kenneth H. Mayer, M.D.• Dean’s Teaching Excellence Award, Brown Medical

School, Brown University, Providence, Rhode Island

• Paul J. Galkin Lecturer for Distinguished Leadershipin HIV/AIDS, Brown University, Providence, RI

Marguerite A. Neill, M.D.• Dean’s Teaching Excellence Award for outstanding

teaching in Bio 282: Pathophysiology-InfectiousDisease, Brown Medical School

Steven M. Opal, M.D.• Brown Medical School Department of Medicine

Chairman’s Award for Excellence in Teaching

• Dean’s Teaching Excellence Award


Josiah D. Rich, M.D., MPH• Preceptorship Award, Rhode Island Hospital, The

Miriam Hospital, and Brown University, “as anoutstanding teacher in the field of internalmedicine”


E. Jane Carter, M.D.• Director, Brown-Moi Medical Exchange Program

• Visiting Professor, Moi University School ofMedicine, Eldoret, Kenya

• Preceptor, Tuberculosis Clinic

House Staff Conference Series:

• The Miriam Hospital; 2 lecture series ontuberculosis

• Rhode Island Hospital; 2 lecture series on activetuberculosis

• Veterans Administration Medical Center; 1 lectureon active tuberculosis

• Pulmonary and Critical Care Fellowship Program,Brown University: Introductory lecture series:Tuberculosis, Diagnosis and Management

Staci Fischer, M.D.• Director, Infectious Disease Fellowship Program

• Infectious Disease Pathophysiology course atBrown Medical School

• Chicago Infectious Disease Board Review course

• Mycology section of microbiology, Brown MedicalSchool

Timothy P. Flanigan, M.D.• Small group leader, Infectious Disease section,

Pathophysiology. Second year medical students

• Lecturer, HIV infection in the developing world,UC107

• Organizer, special session for second year medicalstudents during the Pathophysiology course tomeet and speak with persons with AIDS

• Internal Medicine Ward Attending

• Lecturer at The Miriam Hospital on clinicalmanifestations of HIV/AIDS. Third year medicalstudents during the core of Medical Clerkship

Kenneth H. Mayer, M.D.• Multiple annual lectures to undergraduates; first

and second year Brown University MedicalStudents on:

1) Pharmacology and Mechanisms of Action of Antibiotics2) Antibiotic Resistance3) Epidemiology, Clinical Manifestations and Treatment of HIV/AIDS

• Doctoral thesis advisor and committee member forsix graduate students in either Community Health(Brown), or Epidemiology or Immunology andInfectious Disease (Harvard School of PublicHealth)

• Director, Medical Student Senior Seminar: Lessonsof AIDS, Brown University

• Faculty for University of Rhode Island’s Virologycourse, lecture on “HIV/AIDS”

Leonard Mermel, D.O.• Preceptor, Medicine in Action Program

• Preceptor, Physical Diagnosis (Biomed 373)

• Teaching Attending Physician, Infectious DiseaseConsult Service

• Lecturer, Resident’s Noon Conference

• Faculty Attendee, Resident’s Morning Report

• Lecturer, Critical Care, Hematology/OncologyFellowships; Emergency Medicine, Pediatrics,Neurosurgery Residencies

• Lecturer, National Youth Leadership Forum inMedicine

Maria Mileno, M.D.• Faculty Leader, Alternative Healing and

Complementary Medicine Affinity Group alongwith Dr. James Burrill

• Small group leader and lecturer, Infectious DiseasePathophysiology course

• Immunology Center & Travel Medicine electiverotation

Steven Opal, M.D.• Participant in BC107 each year (burden of

infectious disease on developing countries) and theimmunology of vaccines course by Dr. DeGroot andPaul Knopf.

Edward J. Wing, MD• Program Director, Categorical and Preliminary

Internal Medicine Residency

• Teaching Attending Physician; Inpatient wards andClinical Immunology Center


INFECTIOUS DISEASE FELLOWSHIP PROGRAM

Departing Fellows

Name Medical School Residency Post Graduate Plans

Richard Yap, M.D. University of the Phillipines Downtown Hospital Private Practice –New York University Infectious Disease

Haris Mirza, M.D. King Edward Medical College, Overlook Hospital, NJ/ Private Practice –Paqkistan Columbia University Infectious Disease

Joao Tavares, M.D. Univ. of Coimbra, Portugal Brown Medical School Internal Medicine, Brown

Brenda Urbina, M.D. University of Puerto Rico Yale University/ Director, HIV/AIDSNorwalk Hospital Norwalk Hospital, New

Haven, CT

Michael Poshkus, M.D. Columbia University Brown Medical School Infectious Disease, Brown &Providence, RI Department of Corrections

Pat Cristofaro, M.D. Boston University Brown University/ Infectious Disease, MiriamThe Miriam Hospital and Memorial Hospitals

Current Fellows


Michael Poshkus, M.D. Columbia University Brown Medical School, Internal MedicineRIH/TMH

Troy Martin, M.D. University of Washington Brown Medical School, Internal MedicineRIH/TMH

Rosario Manalo, M.D. University of the East, Philippines Brown Medical School, Internal MedicineMemorial

Curt Beckwith, M.D. Dartmouth/Brown Program Brown Medical School, Internal MedicineRIH/TMH

Arathi Rao, M.D. Kasturba Medical College Western Reserve Hospital

Husam Issa, M.D. Jordan University Scranton-Temple Program

NIH T32 Sponsored Research Fellows


Pat Cristofaro, M.D. Boston University Roger Williams Hospital

Mark Lurie, Ph.D. Hopkins – PhD (Not Applicable)

Clay Merchant, M.D. Emory University Mt. Sinai School of Medicine of NY Univ.

Jonathan Cohen, M.D. New Jersey Medical School Brown Medical School, Internal MedicineRIH/TMH

Erna Kojic, M.D. University of Iceland Brown Medical School, Internal MedicineRIH/TMH

Michael Poshkus, M.D. Columbia University Brown Medical School, Internal MedicineRIH/TMH

Nanetta Payne Louisiana State (BA) Jackson State University (PhD)

Kathy Crockett Univ of Southern MS (BS) Jackson State University (PhD)



Charles C.J. Carpenter, M.D.• Cohen RA, Boland R, Paul R, Tashima KT,

Schoenbaum EE, Celentano DD, Schuman P, SmithDK, Carpenter CCJ. Neurocognitive performanceenhanced by highly active antiretroviral therapy inHIV-infected women. AIDS 2001;15:341-5.

• Tashima KT, Hogan JW, Gardner LI, Korkontelou C,Schoenbaum EE, Schuman P, Rompalo A, Carpenter,CCJ. A longitudinal analysis of hospitalization andemergency department use among humanimmunodeficiency virus-infected women reportingprotease inhibitor use. Clin Infect Dis 2001; 33:2055-60.

• Cu-Uvin S, Hogan JW, Caliendo AM, Harwell J,Mayer KH, Carpenter CCJ for the HIV EpidemiologyResearch Study. Association between bacterialvaginosis and expression of human immunodefi-ciency virus type 1 RNA in the female genital tract.Clin Infect Dis 2001; 33:894-6.

• Yeni PG, Hammer SM, Carpenter CCJ, Cooper DA,Fischl MA, Gatell JM, Gazzard BG, Hirsch MS,Jacobsen DM, Katzenstein DA, Montaner JSG,Richman DD, Saag MS, Schechter M, Schooley RT,Thompson MA, Vella S, Volberding PA. Antiretroviraltreatment for adult HIV infection in 2002. JAMA2002; 288:222-35.

• Tashima KT, Carpenter CCJ. Fusion inhibition – Amajor but costly step forward in HIV-1 treatment. NEng J Med 2003; 348:2249-50.

Timothy P. Flanigan, M.D.• Flanigan TP and Tashima K. Diagnosis of Acute HIV

Infection: It’s Time to Get Moving! Editorial. Ann IntMed 2001; 145:75-77.

• Mitty JA, Stone VE, Sands M, Macalino G, Flanigan T.Directly Observed Therapy for the Treatment ofPeople with Human Immunodeficiency Virus Infec-tion: A Work in Progress. Clin Infect Dis 2002;34:984-990. Cited in Current Topics in HIV Medicine:Using Basic Science to Inform the Best ClinicalPractices. 2002.

• Kumarasamy N, Mahajan A, Flanigan TP, HemalathaR, Mayer KH, Carpenter CCJ, Thyagarajan SP,Solomon S. Total Lymphocyte Count (TLC) Is aUseful Tool for the Timing of Opportunistic InfectionProphylaxis in India and Other Resource-Constrained Countries. J AIDS 2002; 31:378-83.

• Kumarasamy N, Flanigan TP, Mahajan AP, CarpenterCCJ, Mayer KH, Solomon S. Monitoring HIVtreatment in the developing world. Reflection andReaction. The Lancet ID 2002; 2:656-657.

• Rich JD, Ching CG, Lally MA, Murphy MA,Schwartzapfel B, Charuvastra A, Beckwith C, FlaniganTP. A Review of the Case for Hepatitis B Vaccinationof High-Risk Adults. i 2003; 114:316-318.

Joseph Harwell, M.D.• Harwell JI, Fisher D. Pediatric Septic Bursitis: Case

Report of Retrocalcaneal Infection and Review of theLiterature. Clin Infect Dis 2001; 32:e102-4

• Cu-Uvin S, Hogan JW, Caliendo AM, Harwell JI,Mayer KH, Carpenter CCJ. Association between bac-terial vaginosis and expression of HIV-1 RNA in thefemale genital tract. Clin Infect Dis 2001; 33:894-6

• Tashima KT, Alt DN, Harwell JI, Fiebich-Perez DK,Flanigan TP. Internet Sex Seeking Leads to Acute HIVInfection: A Report of Two Cases. Int J STD & AIDS2003;14(4); 285-6.

• Senya C, Mehta A, Harwell JI, Pugatch D, Flanigan T,Mayer KH. Spectrum of Opportunistic Infections inHospitalised HIV-Infected Patients in Phnom Penh,Cambodia. Int J STD & AIDS 2002;14:411-6.

Awewura Kwara, M.D.• Kwara A, Schiro R, Cowan LS, Hyslop NE, Wiser MF,

Roahen Harrison S, Kissinger P, Diem L, Crawford JT.Evaluation of the epidemiologic utility of secondarytyping methods for differentiation of Mycobacteriumtuberculosis isolates. J Clin Micro 2003; 41(6):2683-85.

Michelle A. Lally, M.D., MSc• Pugatch DL, Levesque BG, Lally MA, Reinert SE,

Filippone WJ, Flanigan TP, Brown LK, Combs C. HIVTesting Among Young Adults and Older Adolescentsin the Setting of Acute Substance Abuse Treatment. JAIDS 2001; 27(2):135-142.

• Beckwith C, Lally MA, Flanigan TP. Routine HIVTesting among Inpatients.” (Letter) Arch Int Med2002; 162:2252-2253.

• Simmons E, Lally MA, Flanigan TP. Routine, NotRisk-Based, Human Immunodeficiency Virus TestingIs the Way to Go. (Correspondence) J Infect Dis 2003;187(6):1024.

• Rich JD, Ching CG, Lally MA, Murphy MA,Schwartzapfel B, Charuvastra A, Beckwith CG,Flanigan TP. A Review of the Case for Hepatitis B.Vaccination of High-Risk Adults. The Am J Med 2003;114:316-318.

John Lonks, M.D.• Lonks JR, Garau J, Medeiros AA. Implications of

antimicrobial resistance in the empirical treatment ofcommunity-acquired respiratory tract infections: thecase of macrolides. J Antimicrob Chemother 2002; 50Suppl C:87-92.


• Lonks JR, Garau J, Gomez L, Xercavins M, Ochoa dE,Gareen IF, Reiss PT, Medeiros AA. Failure of macro-lide antibiotic treatment in patients with bacteremiadue to erythromycin-resistant Streptococcuspneumoniae. Clin Infect Dis 2002; 35(5):556-564.

• Lonks JR, Medeiros AA, Garau J, Gareen IF. Reply-Atestament to sustained macrolide efficacy. Clin InfectDis 2003; 36(7):936-937.

Kenneth H. Mayer, M.D.• Mayer KH, Peipert J, Fleming T, Fullem A, Moench T,

Cu-Uvin S, Bentley M, Chesney M, Rosenberg: Safetyand Tolerability of BufferGel, a Novel VaginalMicrobicide, in Women in the United States. ClinInfect Dis 2001; 32:6-482.

• Renzi C, Douglas JM Jr., Foster M, Critchlow CW,Ashley-Morrow A, Buchbinder SP, Koblin BA,McKirnan DJ, Mayer KH, Celum CL: Herpes SimplexVirus Type 2 Infection as a Risk Factor for HumanImmunodeficiency Virus Acquisition in Men WhoHave Sex with Men. J Infect Dis 2003; 187(1):19-25.

• Mayer KH, Karim SA, Kelly C, Maslankowski L, ReesH, Profy AT, Day J, Welch J, Rosenberg Z, for the HIVPrevention Trials Network (HPTN) 020 ProtocolTeam. Safety and tolerability of vaginal PRO 2000 gelin sexually active HIV-uninfected and abstinent HIV-infected women. AIDS 2003; 17(3):1-329.

• Koblin BA, Chesney MA, Husnik MJ, Bozeman S,Celum CL, Buchbinder S, Mayer K, McKirnan D,Judson FN, Huang Y, Coates TJ, and the EXPLOREStudy Team. High-Risk Behaviors Among Men WhoHave Sex With Men in 6 US Cities: Baseline Datafrom the EXPLORE Study. Am J of Public Health 2003;93(6):926-932.

• Chesney MA, Koblin BA, Barresi PJ, Husnik MJ,Celum CL, Colfax G, Mayer K, McKirnan D, JudsonFN, Huang Y, Coates TJ, and the EXPLORE StudyTeam. An Individually Tailored Intervention for HIVPrevention: Baseline Data from the EXPLORE Study.Am J of Public Health 2003; 93(6):933-938.

Leonard Mermel, DO• Polonio RE, Mermel LA, Paquette GE, Sperry JF.

Eradication of biofilm-forming Staphylococcusepidermidis (RP62A) by a combination of sodiumsalicylate and vancomycin. Antimicrob AgentsChemother 2001; 45:3262-3266.

• Mermel LA, Farr BM, Sherertz RJ, Raad II, O’GradyN, Harris JS, Craven DE. Guidelines for themanagement of intravascular catheter-relatedinfections. Clin Infect Dis 32:1249-1272, 2001. Alsopublished in Infect Control Hosp Epidemiol 2001;22:222-42. J Intraven Nurs 2001; 24:180-205. Articlereviewed in National Guidelines Clearinghouse.

• Shah CB, Mittelman MW, Costerton JW, Parenteau S,Pelak M, Arsenault R, Mermel LA. Antimicrobialactivity of a novel catheter-lock solution. AntimicrobAgents Chemother 2002; 46:1674-1679.

• O’Grady NP, Alexander M, Dellinger EP, GerberdingJL, Heard SO, Maki DG, Masur H, McCormick RD,Mermel LA, Pearson ML, Raad II, Randolph A,Weinstein RA. Guidelines for the prevention ofintravascular catheter-related infection. MMWR 51(RR 10): 1-29, 2002 (Erratum 51 (RR10): 711, 2002).Also published in Pediatrics 110:e51, 2002, Clin InfectDis 2002; 35:1281-1307, Am J Infect Control 2002;30:476-489, and Infect Control Hosp Epidemiol 2002;23:759-769.

Jennifer A. Mitty, M.D.• Adelson Mitty J, Stone VE, Sands M, Macalino G,

Flanigan T, Directly Observed Therapy for theTreatment of People with Human ImmunodeficiencyVirus Infection: A Work in Progress. ClinicalInfectious Diseases 2002; 34:984-90 HIV/AIDS

• Harwell JI, Flanigan1 T, Mitty JA, Macalino G,Caliendo AM, Ingersoll J, Stenzel MS, Carpenter CCJ,Cu-Uvin S. Directly Observed Antiretroviral Therapyto Reduce Genital Tract and Plasma HIV-1 RNA inWomen with Poor Adherence. Research Letter. AIDS17(13):1990-93-2003.

Marguerite Neill, M.D.• Guerrant RL, Van Gilder T, Steiner TS, Thielman NM,

Slutsker L, Tauxe RV, Hennessy T, Griffin PM,DuPont H, Sack RB, Tarr P, Neill M, et al. Guidelinesfor Managing Infectious Diarrhea (IDSA). Clin InfectDis 2001; 32:331-51.

• Tarr PI, Neill MA, Watkins SL. Risk of hemolyticuremic syndrome from antibiotic treatment ofEscherichia coli O157:H7 colitis (letter) JAMA 2002;288:3111-2.

Steven M. Opal, M.D.• Cross AS, Opal SM, Warren SH, Palardy JE, Glaser K,

Parejo NA, Bhattacharjee AK. Active immunizationwith a detoxified Escherichia coli J5 lipopolysac-charide group B meningococcal outer membraneprotein complex vaccine protects animals fromexperimental sepsis. J Infect Dis 2001; 183:1079-86.

• Opal SM, Knaub S, Keinecke H-O. Low dose Heparinand High Dose Antithrombin III in severe sepsisJAMA 2002; 287: 448-449.

• Opal SM, Keith JC, Jr., Jhung, J, Palardy JE, Parejo N,Marchese E, Maganti V. Orally administeredrecombinant human interleukin-11 is protective inexperimental neutropenic sepsis. J Infect Dis 2003;187:70-76.

• Opal SM. The clinical relevance of endotoxin inhuman sepsis: a critical analysis. J Endotoxin Res2003; 8(6):473-476.


• Chhin S, Rozycki G, Pugatch D, Harwell JI. Etiologyof Meningitis in HIV-Infected Patients in a ReferralHospital in Phnom Penh, Cambodia. Int J STD &AIDS (in press) 2003

Josiah D. Rich, M.D., MPH• Cannon MJ, Dollard SM, Smith DK, Klein RS,

Schuman P, Rich JD, Vlahov D, Pellett PE. Blood-Borne and Sexual Transmission of HumanHerpesvirus 8 in Women with or at Risk for HumanImmunodeficiency Virus Infection. N Eng J Med2001; 344(9);637-643.

• Rich JD, Macalino GE, McKenzie M, Burris S. SyringePrescription to Prevent HIV Infection in RhodeIsland: A Case Study. Am J Public Health 2001;91(5);699-700.

• Charuvastra A, Stein J, Schwartzapfel B, Spaulding A,Horowitz E, Macalino G, Rich JD. Hepatitis BVaccination Practices in State and Federal Prisons.Public Health Reports 2001; 116:203-209.

• Rich JD, Macalino GE, Merchant RC, Salas C,Marcussen P., Grundy M, Spaulding A. HIVSeroprevalence of Adult Males Incarcerated for aSexual Offense in Rhode Island, 1994-1999. (ResearchLetter). JAMA 2002; 288(2);164-165.

• Allen SA, Spaulding AC, Osei AM, Taylor LE, CabralAM, Rich JD. Treatment of Chronic Hepatitis C in aState Correctional Facility. Ann Int Med 2003;138(2);187-190.

Karen Tashima, M.D.• Tashima KT, Flanigan TP, Kurpewski J, Melanson SM,

Skolnik PR. Discordant human immunodeficiencyvirus type 1 drug resistance mutations, includingK103N, observed in cerebrospinal fluid and plasma.Clin Infect Dis 2002; 35(1):82-3.

• Tashima KT, Alt DN, Harwell JI, Fiebich-Perez DK,Flanigan TP. Internet sex seeking leads to acute HIVinfection: A report of two cases. Int J STD & AIDS2003; 14(4):285-6.

• Tashima KT, Carpenter CCJ. Fusion inhibition – Amajor but costly step forward in HIV-1 treatment.New Eng J Med, 2003; 348(22):2249-50.

Edward J. Wing, MD• Cousens LP, Wing EJ, Liu C-C, Gregory SH:

Expression of perforin- and Fas ligand-mediatedcytolytic activity by CD8 T cells during infectionswith Listeria monocytogenes. American Association ofImmunologists Annual Meeting, Orlando, FL, 2000.

• Wing EJ: Listeria: Hot dogs and CD8 cells. GrandRounds at Dr. Jack Remington’s Festschrift, StanfordSchool of Medicine, Palo Alto, CA, January 2001.

• Wing EJ: Listeriosis. Grand Rounds at MemorialHospital of Rhode Island, January, 2001.

• Cousens LP, Mott S, Wing EJ, Chau-Ching L, GregorySH: CD8 T cells shift from perforin- to fas ligand-mediated cytolysis during primary listeriosis. 11th

International Congress for Immunology, Stockholm,July 22-27, 2001.

• Gregory SH, van Rooijen N, Wing EJ: Neutrophil-Kupffer cell Interaction facilitates innate hostdefenses to systemic bacterial infections. AmericanAssociation of Immunologists, New Orleans, LA,April 20-24,2002.


BASIC RESEARCH

Linda Bausserman, Ph.D.

• Circulating Cell Adhesion Molecules in HIV Infection,NIH/CFAR Developmental Grant Program

• Laboratory Analysis & Development of QC, NationalInstitutes of Health/NERI

• Behavioral Stress on Lipids & Lipoproteins, NationalInstitutes of Health

Daniel Boden, Ph.D.

• HIV-1 RNA Interference, NIH/CFAR DevelopmentalGrant Program

Bharat Ramratnam, M.D.

• RNA Interference in Vivo to Decrease Viral Burden,Lifespan/COBRE Pilot Project

• Daland Fellowship, American Philosophical Society

• Novel Approaches to Target Latent Reservoirs of HIV-1, NIH/National Institutes of Health

• CFAR - Core C: Immunovirology and LaboratoryServices, NIH/National Institutes of Health

• Engineering Mucosal Resistance to Cryptosporidiosis,Culpepper Foundation

• Impact of Mulit-Drug Resistant Proteins on HIVTreatment, Doris Duke CharitableFoundation

CLINICAL RESEARCH

Carpenter, Charles M.D.

• (SUN) Study of Unnatural History of HIV, CDC

• Thundermist project, Thundermist Health Associ-ates/Health Resources & Research Administration

• Center for AIDS Research, NIH/National Institute ofAllergy and Infectious Disease

• Supplement for Underrepresented Minorities (CFAR)- M. Lurie, NIH/National Institute of Allergy andInfectious Disease

• Serostim in the Treatment of HIV-associated AdiposeRedistribution Syndrome (HARS), Serono

• A Muliclinic, Open Study to Evaluate the Ability ofthe Combination of Indinavir, Zidovudine, and

Lamivudine to Result in Sustained Suppression ofHIV-1 in Asymptomatic HIV-1 Seropositive Patients(Merck 060 ext.), Merck Research Laboratories

Jane Carter, M.D.

• Satellife Handheld Computer Project, Satelife

Susan Cu-Uvin, M.D.

• E. Coli Lt as a Rectal andVaginal Muscosal Adjuvant,NIH/National Institutes of Health/Children’sHospital

• AACTG Women’s Health Committee - Susan Cu-Uvin, Vice Chair, NIH/National Institute of Allergyand Infectious Disease

• HIV Drug Resistance in the Genital Tract of Women,NIH/National Institute of Allergy and InfectiousDisease

• Antiviral Therapy and HIV in the Genital Tract ofWomen, NIH/National Institutes of Health

Staci Fischer, M.D.

• Intravenous BMS-284756 Follow-up VersusIntravenous Piperacillin Tazobactam, ICON/BRISTOL-MYERS

Timothy Flanigan, M.D.

• CFAR - Core D: HIV and Women, NIH/NationalInstitute of Allergy and Infectious Disease

• Adult Therapeutic Clinical Trials Program for HIV/AIDS, NIH/National Institute of Allergy andInfectious Disease

• Cerebrospinal Fluid Human ImmunodeficiencyVirus-1 (HIV-1) and Cognitive Function inIndividuals Receiving Potent Antiretroviral Therapy(ACTG 736), NIH/National Institute of NeurologicalDisorders & Stroke/Washington University

• Directly Observed HAART for Active SubstanceAbusers, NIH/National Institutes of Health

• Adapting to HIV: A Family Intervention, NIH/National Institutes of Health/RIH

• HIV and Other Infectious Consequences of SubstanceAbuse, NIH/National Institutes of Health

• Roche-Directly Observed Therapy Fund, Roche



Academic Year 2003 $291,475 $45,424 $336,899

Total Clinical Research Expenses Academic Year 2002 $6,898,363 $1,793,711 $8,692,074

Academic Year 2003 $8,073,656 $1,959,399 $10,033,055


• Expanding the Testing of Sexually TransmittedDiseases in Persons Entering Correctional Facilities,Rhode Island Foundation

• Center for Biodefense and Emerging Pathogens atMemorial Hospital, RI Department of Health/Memorial Hospital

• A Nutrition, Endocrine, Metabolic Center for DrugAbusers, Tufts University/National Institute of Health

• One-on-One Intervention to Increase FemaleEnrollment in ACTG Trials, National Institutes ofHealth/Social and Scientific Systems Inc

• Induction of Anti-HWIGAA, NIH/National Institutesof Health

• Directly Observed Therapy (DOT) for TB and HIV inKenya, NIH/National Institutes of Health

Mary Flynn, Ph.D.

• Nutrition and HIV Infection, NIH/National Institutesof Health/Tufts University

• Principles of Nutrition Course, Brown University

• Comparison of a Mediterranean Diet with a NCEPStep II for Weight Loss and Metabolic Improvement,Rhode Island Foundation

• Comparison of a Mediterranean Diet with a NCEPStep II Diet for Weight Loss and MetabolicImprovement, Canned Vegatable Council

• Comparison of a Mediterranean Diet with a NCEPStep II Diet for Weight Loss and MetabolicImprovement, Carli Olive Oil

• Comparison of a Mediterranean Diet with aConventional Diet for Metabolic Improvement inPatients with Non-Insulin Dependent DiabetesMellitus (NIDDM), Carli Olive Oil

• Comparison of a Mediterranean Diet with aConventional Diet for Metabolic Improvement inPatients with non-Insulin Diabetes Mellitus (NIDD),Lifespan

Joseph Harwell, M.D.

• Clinical Evaluation of Vironstika HIV-1 Plus OMicroelisa System, bioMerieux, Incorporated

• Abuse and Psychiatric Disorders Among Youth, NIH/National Institutes of Health/RIH

• Building Interdisciplinary Research Careers inWomen’s Health, National Institutes of Health/Woman and Infants Hospital

• A Pilot Study of Genital Tract and Blood PlasmaVirology and Pharmacology in HIV-1 InfectedWomen, Rhode Island Foundation

Leah Holmes, LICSW

• Special Projects of National Significance - Outreachand Medical Care for HIV-Positive Ex-Offenders,Health Resources & Services Administration

• Case Management for HIV +Ex-Offenders, RhodeIsland Department of Health

• HIV Prevention Counseling, Testing, Referral, andOutreach Services, RI Dept of Health/Travelers Aid

Awewura Kwara, M.D.

• Molecular Epidemiological Study of Tuberculosis inRhode Island: DNA Fingerprinting and ConventionalAnalyses, Rhode Island Foundation

• Categorical Program for Outpatient EarlyIntervention Services with Respect to HIV Disease -Ryan White Title IIIB Early Intervention Services,Thundermist Health Associates/Health Resources &Research Administration

Michelle Lally, M.D.

HIV Vaccine Trials Network (VTN), NIH/NationalInstitutes of Health/Harvard Medical School

• HIV and Infectious Disease Testing and TreatmentAmong Substance Abusers (K23), NIH/NationalInstitutes of Health

• HIV Rapid Testing Among Substance Abusers, NIH/National Institutes of Health

• Validation of Candidate HIV Vaccine T Cell Epitopes,NIH/National Institutes of Health/Brown University

• Project Prevent: Comprehensive Testing, Treatmentand Prevention of HIV, Hepatitis and STDs toPersons in Drug Detoxification Centers, IttlesonFoundation

• A Phase III trial to Determine the Efficacy ofAIDSVAX B/B Vaccine in Adults at Risk of SexuallyTransmitted HIV-1 Infection in the United States,VaxGen

• A Probe Study of the Safety, Tolerability, andImmunogenicity of a Three Dose Regimen of the Ad5Human Immunodeficiency Virus (HIV-1) GagVaccine (Adenovirus Serotype 5 HIV-1 Gag Vector) inHealthy Adults (Merck 007-00), Merck ResearchLaboratories

• A Phase I Dose-Ranging Study of the Safety,Tolerability, and Immunogenicity of the MerckTrivalent Adenovirus Serotype 5 HIV1 gag/pol/nefVaccine (MRKAd5 HIV-1 gag/pol/nef) in a Prime-Boost Regimen in Healthy Adults, Merck andCompany

John Lonks, M.D.

• In Vitro Activity of Ceftriaxone and Other AgentsAgainst Streptococcus Pneumoniae, Hoffman/LaRoche

• Prevalence of Gatifloxacin (Tequin)-resistance amongStreptococcus Pneumoniae Isolated Blood from NineHospitals, Bristol-Myers Squibb


Grace Macalino, Ph.D.

• HIV Related Applied Research for Control andPrevention of HIV Infection, CDC

Kenneth Mayer, M.D.

• HIV Prevention Trials Network, Fenway CommunityHealth Center

• Behavioral Secondary HIV Prevention Interventionsin India-International Research Collaboration, NIH/National Institute of Allergy and Infectious Disease

• CFAR - Core E: Prevention Science Core, NIH/National Institute of Allergy and Infectious Disease

• Increasing Condom Use with Stage Matched Interven-tion, NIH/National Institutes of Health/URI

• Phase I 14-Day Safety and Acceptability Study of 10%Polystyrene Sulfonate, CONRAD

• Fogarty AIDS International Training and ResearchProgram, NIH/National Institutes of Health/FogartyInternational Center

• Johns Hopkins University “NIMH Collaborative HIV/STD Prevention Trial”, NIH/National Institute ofMental Health/Johns Hopkins University

• Prevention Trials Network, Protocol 050, NIH/National Institutes of Health/Fenway CommunityHealth Center

• Prevention Trials Network, Protocol 049, NIH/National Institutes of Health/Fenway CommunityHealth Center

• New England AIDS Education and Training Center,HRSA/University of Massachusetts

Antone Mederios, M.D.

• A6J-MC-V010 - MRSA vs. MSSA, Lilly Research

• Healthcare Associated Infections & AntimicrobialResistant Infections, Centers for Disease Control(CDC)

Leonard Mermel, D.O

• Phase III Randomized Evaluation Committee BlindedStudy to Assess the Safety Central VenousCatheterization, Omnicare Clinical Research

• Use of a Taurolin Flush to Prevent Long-termIntravascular Catheter Infections, Carter-WallaceIncorporated

• A Prospective, Randomized Blinded Controlled Trialof a Taurolidine Flush Solution for the Prevention ofCatheter Related Infections, Carter-Wallace,Incorporated

• Linezolid vs. Vancomycin for the Treatment of Com-plicated Skin and Soft Tissue Infections Suspected ofBeing or Proven to be due to Methicillin ResistantGram Positive Bacterial Pathogen, Pharmacia,Incorporated

Maria Mileno, M.D.

• The Effect of Formulary Conversion From Ceftazi-dime to Cefepime on the In Vitro Sensitivities ofPseudomonas aeruginosa, Enterbacter Cloacae andKlebsiella pneumoniae to Selected Antibodies, KendleInternational Inc.

Jennifer Mitty, M.D.

• Directly Observed Therapy (DOT) to EnhanceAdherence to a Once-A-Day Highly ActiveAntiretroviral Therapy (HAART) Regimen AmongSubstance Abusers, Bristol-Myers Squibb

• Directly Observed Therapy (DOT) to EnhanceAdherence to a Once-a-Day Highly Active Antiretro-viral Therapy (HAART) Regimen Including Teno-fovir Among Hard to Reach Populations, GileadSciences

• Observed Therapy to Enhance Adherence to HighlyActive Antiretroviral therapy in Pregnant andPostpartum Women, Ingelheim

• Metabolic Changes among HIV SeropositiveSubstance Users on Directly Observed Once-DailyHighly Active Antiretroviral Therapy (HAART),National Institutes of Health/Tufts University

Stephen Opal, M.D.

• Evaluation of Anti-endotoxin Vaccine for HumanUse, National Institutes of Health

• The Role of Interleukin-II as a Therapeutic StrategyAgainst Anthrax Exotoxin, Genetics Institute

• Phase III International Trial of Recombinant HumanPlatelet Activating Factor Acetyl-Hydrolase in theTreatment of Severe Sepsis, ICOS

Josiah Rich, M.D.

• Physician Patient IDU’s Pilot, SAMHSA

• Blood Born Infections Among Imprisoned DrugUsers, National Institutes of Health/Johns Hopkins

• A Trial to Reduce Hepatitis C Among Injection DrugUsers, NIH/National Institutes of Health/RIH

• Program to Improve Access to HIV Specialist MedicalCare, Rhode Island Department of Health

• Hepatitis B Vaccination of Prisoners, Centers forDisease Control (CDC)

• Overdose Prevention, Recognition and TreatmentUsing Naloxone, The Tides Foundation

• AMA questionairre, Robert Wood JohnsonFoundation/Temple University

• Outreach and Methadone for Former Prisoners, NIH/SAMHSA

• Access to HIV/HCV Prevention after syringe LawChange (Sapphire) Study, NIH/National Institute ofDrug Abuse/Brown University


• Outpatient Early Intervention Services with Respectto HIV Disease, HRSA

• Hepatitis C Care, Schering Plough

Emma Simmons, M.D.

• Project SEARCH: Acceptability and Feasibility ofRoutine HIV Testing in Primary Care Settings, NIH/National Institute of Allergy and Infectious Disease

Karen Tashima, M.D.

• A Randomized, Open-Label, Phase III Study of ABT-378/Ritonavir in Combination with Nevirapine andTwo Nucleoside Reverse Transcriptase Inhibitors vs.Investigator Selected Protease Inhibitor(s) inCombination with Nevirapine and Two NRTI’s inAntroviral-therapy, Abbott Laboratories

• Randomized, Open-Label, Comparative Safety andEfficacy Study of Tipranavir Boosted with Low-DoseRitonavir versus Genotypically-Defined ProteaseInhibitor/Ritonavir in Multiple Antiretroviral Drug-Therapy, Ingelheim

• DMP 266 004,005, 006, DuPont Merck

• A Probe Study to Evaluate the Safety, Tolerability, andImmunogenicity of the Adenovirus Serotype 5 Vector(MRKAd5) Human Immunodeficiency Virus Type 1(HIV-1) gag Vaccine in HIV-1 Infected Patients,Merck and Company

• A 96-Week, Randomized, Open-Label, MulticenterTrial to Evaluate the Safety and Tolerability of theAntiretroviral Activity of Stavudine and Lamivudineand Nelfianavir vs. Abacavir and Combivir vs.Combivir and Nelfinavir in HIV-1 Infected FemaleSubjects, Glaxo Wellcome

• A Phase III, 1:1 Randomized, Double-Blind,Controlled, Multicenter Trial Comparing the Efficacyand Safety of Abacavir versus Zidovudine WhenCombined with Lamivudine and Efavirenz forTreatment of HIV-1 Infection in AntiretroviralTherapy Naïve Adults, Glaxo Wellcome

• A Phase 3, Randomized, Double blind, MulticenterStudy of the Treatment of Antiretroviral-Naïve, HIV-1-Infected Patients Comparing Tenofovir DisoproxilFumarate Administered in combination withLamivudine & Efavirenz versus Stavudine,Lamivudine & Efavire, Gilead Sciences

• A Phase III, 48-week, Randomized, Double-Blind,Multicenter Study to Evaluate the Safety and Efficacyof Abacavir 600mg once Daily vs. Abacavir 300mgBID in Combination with Lamivudine and Efavirenzin Antiretroviral Therapy Naïve HIV-1 InfectedPatients, GlaxoSmith Kline

• A Randomized, Partially Blinded, Multicenter, PhaseIII, Three Arm Study Evaluating the Efficacy andSafety of Peginterferon alfa-2a (Ro 25-8310 versus

Combination Therapy of Interferon alfa-2a (Ro22-8181) with Ribavirin for 48 Weeks and 24 Weeks…,Hoffman/LaRoche

• A Probe Study to Evaluate the Safety, Tolerability, andImmunogenicity of the Adenovirus Serotype 5 VectorHuman Immunodeficiency Virus Type 1 gag Vaccinein HIV-1 Infected Patients, Merck Res. Labs

• A Phase III, Randomized, Multicenter, Parallel Group,Open-Label, Three Arm Study to Compare theEfficacy and Safety of Two Dosing Regimens ofGW433908/Ritonavir versus Lopinavir/Ritonavir for48 weeks in Protease Inhibitor Experienced HIV-Infected Adults, GlaxoSmith Kline

• An Open-label Phase III Study to Assess the LongTerm Safety Profile of GW433908 Containing Regi-mens in HIV-1 Infected Adults, GlaxoSmith Kline

• A Probe Study to Obtain Peripheral BloodMononuclear Cell (PBMC) Samples from HIV-1Infected Individuals in Order to Evaluate HIV-1Specific Cellular Immune Responses in Subjects onHighly Active Antiretroviral Therapy (Protocol Merck005), Merck Research Laboratories

• A Phase IV Investigation to Compare CSF andGenital Secretion Virology and Tenofovir Levels withPlasma Levels in HIV-1 Infected Patients who areART Naïve or Failing an Antiretroviral Regimen,Gilead Sciences

• A Phase III, 48-week, Randomized, Double-Blind,Multicenter Study to Evaluate the Safety and Efficacyof Abacavir 600mg once Daily vs. Abacavir 300mgBID in Combination with Lamivudine and Efavirenzin Antiretroviral Therapy Naïve HIV-1 InfectedPatients, GlaxoSmithKline

• A Phase III Randomized, Open-Label, MulticenterStudy of the Safety and Efficacy of Efavirenz VersusTenofovir when Administered in combination withthe Abacavir/Lamivdine Fixed -Dose combinationTablet as a Once-Daily Regimen in AntiretroviralNaïve HIV-, GlaxoSmithKline

Lynn Taylor, M.D.

• Pilot study to evaluate a multidisciplinary treatmentand support program to treat hepatitis C virus(HCV) in patients coinfected with jumanimmunodeficiency virus (HIV), Lifespan

• Coninfection Support Group, Roche Laboratories

Brenda Urbina, M.D.

• ACTG 2002 Minority AIDS Training Program,National Institutes of Health/Social and ScientificSystems Inc

N E P H R O L O G Y

Lance Dworkin, M.D., Professor of Medicine; Director, Division of Nephrology

Overview

The Division of Renal Diseases continued toexperience significant growth in clinical and academicprograms during the past two academic years. This wasmost obviously manifest by the addition of four newfaculty to the division. Dr. Andrew Bostom wasrecruited from Pawtucket Memorial Hospital andjoined the division in July 2001. Dr. Bostom has insti-tuted a clinical practice devoted to the management ofsevere dyslipidemia among patients with establishedcardiovascular or renal disease, and those at high riskfor de novo cardiovascular disease. His researchprogram in the Division of Renal Diseases focuses onthe identification and management of potential riskfactors contributing to the excess incidence ofarteriosclerotic outcomes in patients with chronicrenal disease. He is the Principal Investigator for twoNational Institutes of Health grants supporting theseresearch efforts. “Serum Total Homocysteine and C-Reactive Protein as Predictors of ArterioscleroticOutcomes in The Irbesartan Type 2 DiabeticNephropathy Trial (IDNT)” is an observational study

NEPHROLOGY

funded by the National Heart, Lung, and BloodDiseases Institute. The study will determine baselineserum total homocysteine (tHcy) and C-reactiveprotein (CRP) concentrations in the IDNT to evaluatethe potential independent relationship between theseputative CVD risk factors and subsequent CVDmorbidity and mortality, in this patient population.“The Folic Acid for Vascular Outcome Reduction InTransplantation (FAVORIT)”, is a multi-center, rando-mized, double-blind controlled clinical trial sponsoredby the National Institute of Diabetes & Digestive &Kidney Diseases. This 8-year trial is designed todetermine whether treatment with a standard multi-vitamin augmented with high doses of folic acid,vitamin B

6 and vitamin B

12 reduces the rate of cardio-

vascular disease outcomes in renal transplant (graft)recipients relative to participants receiving a similarmultivitamin that contains no folic acid and lower(i.e., Estimated Average Requirement) amounts ofvitamins B

6 and B

12. The FAVORIT trial will

demonstrate whether or not tHcy-lowering treatmentis effective in reducing CVD outcomes among renaltransplant recipients. Moreover, the findings will beapplicable to the much larger overall pool of patientswho have chronic renal insufficiency. With 4000


participants drawn from 20 major North Americanand Canadian renal transplant centers, FAVORIT is thelargest study of CVD prevention ever undertaken inthe chronic renal disease patient population.

Dr. Purba Biswas is a physician-scientist who joinedthe faculty in April, 2003, following completion of anephrology fellowship at Yale University followed by apost-doctoral fellowship in the laboratory of Dr. PeterMadri in the Pathology Department at Yale. Dr. Biswaswas recruited to establish an independent basic scienceresearch program and has office and laboratory spacein the Aldrich Building on the Rhode Island Hospitalcampus. Her interests are in the area of endothelialbiology, adhesion molecules and their role in acute andchronic renal disease.

Dr. Susie Lee Hu will be joining the division beginningAugust, 2003 having recently completed a nephrologyfellowship at Tufts/New England Medical Center. Dr.Hu’s primary focus will be clinical nephrology with anemphasis on the care or patients with end stage renaldisease. She will help supervise our outpatient dialysisprogram, direct the renal clinic at the Veteran’sAdministration Hospital and attend on the inpatientservices at Rhode Island Hospital, The MiriamHospital and the VA. She will also participate invarious clinical research projects involving patientswith diverse types of renal disease.

Dr. Ali Nayer has also been recruited to join thedivision beginning September, 2003. Dr. Nayerreceived his residency training in Internal Medicineand Pathology in the Brown program at MemorialHospital in Pawtucket and then completed anephrology fellowship at Brigham & Women’s Hospitalin Boston. Dr. Nayer will join the group conductingbench research in the division’s laboratory space in theAldrich Building. Dr. Nayer has an interest inmorphometric methods of assessing renal injury aswell as in the biology of rejection in transplantedkidneys. His clinical work will focus on the care ofpatients with End Stage Renal Disease on dialysis.

During the past year, the Division continued to expandits clinical activities in providing renal replacementtherapy to patients with acute and chronic renaldisease. Use of Continuous Veno-VenousHemodiafiltration (CVVHDF), which was introducedthe preceding year, continued to grow in the intensivecare units at Rhode Island Hospital and has now beensuccessfully performed in the surgical and medicalIntensive Care Units as well as in the Coronary CareUnit. CVVHDF is a form of continuous renalreplacement therapy that is used primarily to treathemodynamically unstable, critically ill patients withacute renal failure. Continued growth of the program

particularly during the aftermath of the StationNightclub fire necessitated the purchase of a thirdCVVHDF machine this past year. The inpatientdialysis units at both the Rhode Island and MiriamHospitals also remain quite busy and performapproximately 8000 dialysis treatments per year,primarily to hospitalized patients with acute andchronic renal disease. The Dialysis Unit at RhodeIsland Hospital also provides plasmapheresis topatients with a variety of renal, hematologic andneurologic disorders.

Until recently, the Division had played a rather limitedrole in outpatient dialysis programs across the state.This changed significantly in January, 2003, with theinitiation of a new agreement between FreseniusMedical Care, the largest provider of dialysis services inthe United States and the University MedicineFoundation by virtue of which Dr. Lance Dworkinbecame Medical Director of all Fresenius operateddialysis programs in Rhode Island. As a result, Divisionfaculty now provide medical leadership at fouroutpatient dialysis centers in East Providence, NorthProvidence, Warwick and Woonsocket that care forapproximately 350 patients with end stage renaldisease. We also direct the inpatient dialysis programsat six additional institutions including The MiriamHospital, Memorial Hospital, Newport Hospital, andLandmark Hospital. This has greatly expandedopportunities for division faculty to teach and conductresearch in this important patient population. Inaddition, it should allow for significant growth in ouroutpatient dialysis practice

The Division has ongoing active programs in bothbasic and clinical research. Major expansion in theclinical research program occurred with the recruit-ment of Dr. Bostom as discussed above. Ongoing is theFolic Acid for Vascular Outcome Reduction inTransplantation (FAVORIT) study, of which divisionmember Andrew Bostom is the prinicipal investigator.FAVORIT will determine whether or not loweringhomocysteine levels by vitamin supplementationreduces adverse cardiovascular events in renal trans-plant recipients. Transplant physicians Reg Gohh andAngelito Yango are also actively involved in thisproject. In addition to Dr. Bostom’s large trial, Dr,Dworkin is the study chair for a large consortium ofinvestigators (80 enrolling centers) that recentlyresubmitted a proposal for a large multicenter clinicaltrial designed to determine the best therapy forpatients with renal vascular disease. The CORAL studywill compare the effects of renal artery angioplasty andstenting versus optimal medical therapy on combinedcardiovascular and renal outcomes in 1100 patientswith atherosclerotic renal vascular disease and

N E P H R O L O G Y

hypertension. The application consisting of a cluster of5 RO1 applications with a combined budget ofapproximately $27 million dollars for the 6 six yearproject was submitted to NHLBI in June, 2003. Otherfunded clinical studies currently underway includeprotocols examining the effects of newerimmunosuppressive agents on the course of IgAnephropathy.

The Division currently employs 3 full-time researchcoordinators and, on average, more than a dozenclinical trials are underway at any given time involvingdivision faculty and fellows. These trials have enrolledpatients with diverse diseases, including acute andchronic renal failure, hypertension, diabetes as well asdyslipidemia. The clinical research program includesNIH, industry and investigator initiated, internallyfunded trials that have lead to numerous presentationsand peer-reviewed publica-tions in the past year.

Dr. Lance Dworkin directs the basic science researchprogram, which involves close collaboration withAbdallah Rifai, a PhD investigator in the Departmentof Pathology. The main thrust of the laboratoryprogram is investigation of the mechanisms ofprogression of chronic kidney disease. The NIHfunded laboratory program incorporates a variety oftechniques, from physiologic studies in whole animalmodels of chronic kidney disease, to cell culture, toadvanced molecular methods including gene profiling.The laboratory has consistently produced data that hasbeen presented at national and international meetings.There is an important educational component to thelaboratory program as well, which providesopportunities for students, residents, renal fellows, andpost-doctoral research fellows to gain experience inlaboratory investigation.

The Division of Renal Diseases performs between 100and 200 biopsies annually of native or transplantedkidneys. Typically, this procedure incorporatesultrasound localization of the kidney, which, in thepast, was performed in collaboration with theradiology department. Recently, the Division acquiredits own ultrasound machine, enabling us to performkidney biopsies at the bedside. This has resulted inincreased efficiency and convenience for our patients,and has significantly enhanced our ability to performthis important procedure particularly in renaltransplant patients. In this patient population,subclinical chronic allograft rejection is an importantproblem leading ultimately to graft loss. Subclinicalrejection can be detected by performing protocoldriven renal biopsies on a regular schedule and such abiopsy program is being implemented in ourtransplant population facilitated by the availability of

bedside ultrasound. The ultrasound machine will alsobe used to localize vessels for the placement of dialysiscatheters, a technique that has been shown to reducecomplications and improve success rates for thisprocedure. The availability of ultrasound also enhancesour training programs by allowing fellows to gainexpertise in this important technique.

The renal fellowship at Brown University has been inexistence for more than 30 years. During the past 2years, we continued to experience increased interest inour nephrology training program, which enrolls threefellows each year and this past year received over 150applications before the selection process wascompleted in early January, 2003. The recruitmentseasons in 2001-2003 were highly successful withapplications from residents from our own program aswell as from other first rate academic institutions. Ourfellows now rotate through Rhode Island Hospital, TheMiriam Hospital, and the VA Hospital where theycontribute significantly to patient care as well asresident and medical student education.

Transplantation

The Division of Organ Transplantation continues to beextremely active, with a total of 84 kidneystransplanted during the past calendar year. Thisrepresents the most transplants ever performed by asingle center in New England. This accounts for almost1100 clinic visits to the transplant nephrologists atRhode Island Hospital, providing ample experience fortraining fellows. Another milestone recently reachedwas the completion of 400th transplant performed atRhode Island Hospital since the programs inception 6years ago. This year also saw the introduction ofpancreas transplantation to the program. Thisprocedure, performed typically in individuals that havealso received a kidney transplant, markedly improvesquality of life for patients with insulin dependantdiabetes mellitus.

Transplant Research

The Transplant Division continues to participate in anumber of pharmaceutical company sponsored studiesevaluating the efficacy of various drug regimens inpreventing renal allograft rejection. We also participatein two NIH-sponsored studies including the FAVORITstudy and Dr. Roy Aaron’s study (Identification andTreatment of Osteonecrosis of the Hip). Dr. Gohh alsoconducts independent research on the prevention andtreatment of recurrent FSGS in renal transplantrecipients and the safety and feasibility of renaltransplantation in HIV infected individuals (inconjunction with Dr. Stacy Fischer of the Division of



Lance D. Dworkin, M.D., Director, Professor, RhodeIsland Hospital, University Medicine Foundation

J. Gary Abuelo, M.D., Associate Professor, RhodeIsland Hospital, University Medicine Foundation

Andrew J. Beaulieu, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Purba Biswas, M.D., Assistant Professor, Rhode IslandHospital, University Medicine Foundation

Andrew G. Bostom, M.D., M.S., Associate Professor,Rhode Island Hospital, University MedicineFoundation

Reginald Gohh, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Douglas Shemin, M.D., Clinical Associate Professor,Rhode Island Hospital, University MedicineFoundation

Angelito Yango, Jr., M.D., Clinical Assistant Professor,Rhode Island Hosp., University Medicine Foundation

VOLUNTEER FACULTY

Joseph Chazan, M.D., Clinical Professor, Rhode IslandHospital

Jeffrey Clement, M.D., Clinical Assistant Professor,Miriam Hospital

Christopher Cosgrove, M.D., Clinical Instructor,Rhode Island Hospital

Richard Cottiero, M.D., Clinical Associate Professor,Miriam Hospital

Raymond Endreny, M.D., Clinical Associate Professor,Rhode Island Hospital

Boyd P. King, M.D., Clinical Associate Professor,Rhode Island Hospital

Thomas Krahn, M.D., Clinical Assistant Professor,Rhode Island Hospital

George Lee, M.D., Clinical Instructor, Rhode IslandHospital

Charles E. McCoy, M.D., Clinical Associate Professor,Rhode Island Hospital

Ildiko Medve, M.D., Clinical Instructor, Rhode IslandHospital

Mark Siskind, M.D., M.S., Clinical Assistant Professor,Rhode Island Hospital

Michael Thursby, D.O., Clinical Instructor, RhodeIsland Hospital

Marc Weinberg, M.D., Clinical Associate Professor,Miriam Hospital

David C. Yoburn, M.D., Clinical Associate Professor,Memorial Hospital of Rhode Island

Steven Zipin, M.D., Clinical Assistant Professor,Miriam Hospital

FACULTY TRANSITIONSNew Faculty


Purba Biswas, M.D. Yale Univ. Sch Med, Depts Medicine & Pathology Assistant Prof.

Andrew G. Bostom, M.D., M.S. Memorial Hospital of Rhode Island Associate Prof.

Christopher Cosgrove, M.D. Yale New Haven Hospital Clinical Instr.

Michael Thursby, D.O. Nephrology Fellow, Rhode Island Hospital Clinical Instr.

Angelito Yango, Jr., M.D. Nephrology Fellow, Rhode Island Hospital Clin. Assist. Prof.

Infectious Diseases). The division is also currentlyparticipating in an NIH sponsored trial investigatingthe utility of intravenous immunoglobulin as an agentto reduce anti-HLA antibodies and improvetransplantation results in cross match positive livingdonor kidney allograft recipients. Dr. Yango hasrecently introduced a program for protocol renalbiopsies for all transplant recipients in our center forprimary and secondary prevention of chronic allograftnephropathy. In addition, we are also actively conduct-ing pilot studies in the area of inducing specificunresponsiveness with donor specific peripheral bloodmobilized bone marrow stem cells in recipients ofliving donor mismatched renal allografts.

N E P H R O L O G Y


J. Gary Abuelo, M.D.Invited Presentations:

• “Resistant Hypertension and HypertensiveEmergencies”. Luis E. Aybar Hospital, 5th InternationalCongress, Santo Domingo, May 2003

Purba Biswas, M.D.• American Heart Association Fellowship Award

Andrew G. Bostom, M.D., M.S.Invited Presentations:

• “The Kidney and Homocysteine Metabolism”, ASN/ISN World Congress of Nephrology, San Francisco,CA

• “Management of Dyslipidemia in Chronic RenalDisease”, Renal Grand Rounds, Rhode IslandHospital, Providence, RI

• “Measurement and Parameters and Methodologies inChronic Renal Disease, ASN Renal Week,Philadelphia, PA

Lance D. Dworkin, M.D.• Fellow, American College of Physicians/American

Society of Internal Medicine

• Member, Editorial Board, Clinical Nephrology

• Visiting Professor, Tokai and Osaka Universities,Japan

• Medical Director, Artificial Kidney Centers of RhodeIsland (East Providence, North Providence,Woonsocket, Warwick Outpatient Dialysis Centers,Inpatient Dialysis Programs).

• 5th Congreso Internacional Dr. Marieni Cabral, SantoDomingo, DR, Invited Speaker, May 2003

Reginald Gohh, M.D.Appointed to Medical Staff, Artificial Kidney Center of

Rhode Island, Providence, Rhode Island

Three abstracts accepted for poster presentation:

• Kim E, Gohh R, Simpson M, Monaco A, Morrissey P.Rapid steroid withdrawal versus standard steroidtreatment in patients treated with Basiliximab,Cyclosporine, and Mycophenolate Mofetil for theprevention of acute rejection in kidneytransplantation: a two year follow-up. AmericanSociety of Transplantation, 22nd Annual ScientificMeeting, Washington, DC

• Morrissey PE, Gohh RY, Yango AF, Kestin A, GautamA, Monaco AP. Anticoagulation permits successfulrenal transplantation in patients withantiphospholipid antibody syndrome (APAS).American Society of Transplantation, 22nd AnnualScientific Meeting, Washington, DC

• Gohh R, Fischer S, Morrissey P, Gautam A, MonacoA, Yango A, Akhlaghi F. The pharmacologicinteraction between anti-retroviral agents andtacrolimus. Abdominal Organ Transplantation formLiving Donors: State of the Art, Gubbio, Italy

Douglas Shemin, M.D.• Named Chairman Elect, End Stage Renal Disease

Network of New England

• Named Associate Medical Director, Artificial KidneyCenter of North Providence, and Associate MedicalDirector, Artificial Kidney Center of Warwick.

• Named “One of Rhode Island’s Top Doctors”, RhodeIsland Monthly magazine

Angelito Yango, Jr., M.D.Invited Presentation:

• Transplant Grand Rounds, “HumoralImmune Response in Transplant Recipients”

• Transplant Grand Rounds, “Hepatitis C in KidneyTransplantation”

• Nurse’s Lecture Series, “Medical Aspects of KidneyTransplantation”


Lance D. Dworkin, M.D.• National Kidney Foundation Executive Committee of

the Council on Hypertension

• Medical Advisory Board, National KidneyFoundation of Massachusetts, Rhode Island, NewHampshire & Vermont

• Homer W. Smith Award Committee, American HeartAssociation, American Society of Nephrology

• American Society of Nephrology, GovernmentRelations Committee

• National Institute of Health, General Medicine BStudy Section & Urology Special Emphasis Panel

• Chairman, American Society of Nephrology Ad-hocPublic Policy Priorities Working Group on IncreasingR01 grants for kidney disease research


• Harvard Medical School, Intensive Board Review andContemporary Issues in Nephrology

Reginald Gohh, M.D.• Medical Advisory Board, National Kidney

Foundation – Regional Board of Directors ofMassachusetts and Rhode Island

• Board of Directors and Chairman of TransplantCommittee, ESRD Network of New England

Douglas Shemin, M.D.• American Society of Nephrology, 2003 Annual

Meeting Abstract Reviewer

TEACHING ACTIVITIES

EDUCATION HONORS

Lance D. Dworkin, M.D.• Brown Medical School Dean’s Teaching Excellence

Award

Angelito Yango, Jr., M.D.• Phi Sigma Biological Honor Society

• Leo Davidoff Award for Excellence in Teaching

• Young Investigator’s Award


J. Gary Abuelo, M.D.• Program Director, Nephrology Fellowship

• Co-Course Leader, Renal Pathophysiology, BrownMedical School

Andrew Beaulieu, M.D.• Lecturer/Small Group Facilitator, Renal

Pathophysiology Course, Brown Medical School

• Involved in teaching of Internal Medicine Residents,Brown Medical Students, and Internal Medicine Staffthrough teaching rounds and noon conferences

• Attending Rounds, Rhode Island Hospital

• Medical Director, Providence VA Hemodialysis Unit;Provide instruction to second-year renal fellows onhemodialysis over a six month period

Lance D. Dworkin, M.D.• Small Group Leader, Renal Pathophysiology, Brown

Medical School

• Noon Conference Lecture Series, Rhode Island andMiriam Hospitals

• Renal ICU Rounds, Miriam Hospital, Lecturer

• Physiology Conference, Lecturer

• Hypertension Lecture, Ambulatory Block RotationMedical Residency

• Preceptor with medical students

Reginald Gohh, M.D.• Lecturer/Small Group Leader, Renal Pathophysiology

(Biomed 281)

• Longitudinal Clinic Preceptor, Precept a 3rd yearmedical student on a weekly basis

• Provide lectures on renal pathophysiology andtransplant related issues to residents and fellowsincluding morning report, noon conferences.

• Attending physician on both the renal and transplantelectives during which all consults and admissions arediscussed in detail

• Organizer of monthly CME activity – TransplantConference

• Organizer of renal pathophysiology lecture series forstudents/residents taking renal elective – RotatorConference

• Teaching attending for inpatient ward team

• Clinic attending – attend the transplant clinic inconjunction with the renal fellows

Douglas Shemin, M.D.• Co-Course Leader, Renal Pathophysiology, Brown

Medical School

• Preceptor, Internal Medical Clerkship, Rhode IslandHospital

• Instructor, Advanced Human Pathophysiology,University of Rhode Island College of Pharmacy

• Chairman, Department of Medicine CurriculumCommittee, Brown University School of Medicine

Angelito Yango, M.D.• Lecturer/Small Group Leader, Renal Pathophysiology

(Biomed 281)

• Resident lecture series on renal physiology/acid baseproblems/renal transplantation

• Attending physician on both renal and transplantelectives for fellows, residents and medical students

• Teaching attending for inpatient ward team

• Clinic attending with renal fellows for generalnephrology and transplant clinics

N E P H R O L O G Y

NEPHROLOGY FELLOWSHIP PROGRAMDeparting Fellows

Name Medical School Residency Post Graduate PlansEleas Chafouleas SUNY HSC Syracuse Fletcher Allen Health Care Clinical practice in CT

Medical School

Elkin Estrada Howard University Brown University Joined private practice inProvidence, Hypertension &

Nephrology Assoc.

Paul Shin UMDNJ Medical School Brown University Clinical practice in IL

Brendan Smyth Medical University of University of Nebraska Joined Univ. of PennsylvaniaSouth Carolina Medical Center School of Medicine, Renal

Electrolyte & Hyperten. Div.

Michael Thursby Midwestern University, Brown University Joined a private practice inChicago, College of East Providence, NephrologyOsteopathic Med. Associates

Martin Tran Kirksville Osteopathic Evanston NW Clinical practice in TNMedical School Health CareCurrent Fellows

Current Fellows


Michael Capicotto SUNY Brooklyn, NY Brown Medical School

Patricia Zuniga UniversityRovira/Virgili, Spain Pinnacle Health Hospitals, PA

Natalie Hsu Brown Medical School RI and Miriam Hospitals


J. Gary Abuelo, M.D.• Abuelo, J. Gary. Independent research:

Characterization of systolic blood pressure riseduring hemodialysis, manuscript in preparation.Review article: The many faces of light chainnephropathy, manuscript in preparation.

• Abuelo, J. Gary. Review article: Normotensiveischemic acute renal failure. Accepted for publication.RI Medical Journal 2003

Purba Biswas, M.D.• Biswas P, Schoenfeld JD, Madri JA.. PECAM-1

promotes beta-catenin accumulation and stimulatesendothelial cell proliferation. Biochem Biophys ResCommun. 2003 Mar; 303(1): 212-18.

• Solowiej A., Biswas P, Graesser D, Madri JA. Lack ofplatelet endothelial cell adhesion molecule-1attenuates foreign body inflammation because ofdecreased angiogenesis. Am J Pathol. 2003 Mar;162(3): 953-62.

Andrew Bostom, M.D.• Friedman AN, Hunsicker LG, Selhub J, Bostom AG.

Collaborative Study Group. Proteinuria as a predictorof total plasma homocysteine levels in type 2 diabeticnephropathy. Diabetes Care. 2002; 25(11): 2037-41.

• Bostom AG, Kronenberg F, Ritz E. Predictiveperformance of renal function equations for patientswith chronic kidney disease and normal serumcreatinine levels. J Am Soc Nephrol. 2002; (8): 2140-4.

• Bostom AG, Jacques PF, Liaugaudas G, Rogers G,Rosenberg IH, Selhub J. Total homocysteine loweringtreatment among coronary artery disease patients inthe era of folic acid-fortified cereal grain flour.Arterioscler Thromb Vasc Biol. 2002; 22(3): 488-91.

• Bostom AG, Kronenberg F, Jacques PF, Kuen E, Ritz E,Konig P, Kraatz G, Lhotta K, Mann JF, Muller GA,Neyer U, Riegel W, Schwenger V, Riegler P, Selhub J.Proteinuria and plasma total homocysteine levels inchronic renal disease patients with a normal rangeserum creatinine: critical impact of true glomerularfiltration rate. I. 2001; 159(1): 219-23.

• Bostom AG, Selhub J, Jacques PF, Rosenberg IH.Power Shortage: clinical trials testing the“homocysteine hypothesis” against a background offolic acid-fortified cereal grain flour. Ann Intern Med.2001; 17;135(2): 133-7.

Lance D. Dworkin, M.D.• Dworkin LD. Antihypertensive Agents and Renal

Protection: Are There Important Differences?Nephrology Frontier, 2002 March; 1(1):25-35.


• Yano N, Fadden-Paiva K, Endoh M, Sakai H,Kurokawa K, Dworkin LD, Rifai A. Profiling the IgAnephropathy renal transcriptome: analysis bycomplementary DNA array hybridization.Nephrology, 2002 August; S140-S144.

• Yango A, Morrissey P, Monaco A, Gohh R,Centracchio J, Dworkin LD. Renal Production ofHGF increases after unilateral nephrectomy in man.Transplant Proceedings, 2002 Dec; 34(8):3128-3129.

• Yango A, Morrisey P, Zanabli A, Beaulieu, J, SheminD, Dworkin LD, Monaco A, Gohh R. ComparativeStudy of Prophylactic Oral Gancyclovir andValcyclovir in high-risk kidney transplant recipients.Nephrol Dial Transplant, 2003 January; 18:1-5.

• Dworkin LD, Gong R, Tolbert E, Centracchio J, YanoN, Zanabli A, Esparza A, Rifai A. HGF amelioratesprogression of interstitial fibrosis in rats withestablished renal injury. Kidney International, in press2003.

Reginald Gohh, M.D.• Morrissey P, Gohh R, Monaco A. A novel scale of

immunosuppression exposure and correlation tooutcomes after renal transplantation. Transplant Proc2002; 34(5): 1640.

• Morrissey PE, Ramirez PJ, Gohh RY, Yango AF, KestinA, Madras PN, Monaco AP. Management ofthrombophilia in renal transplant patients. Am JTransplant 2002; 2(9): 872-6.*

• Yango A, Morrissey P, Gohh R, Wahbeh A, Monaco A.Donor-transmitted parvovirus infection in a kidneytransplant recipient presenting as pancytopenia andallograft dysfunction. Transpl Infect Dis 2002; 4(3):163-6.

• Yango A, Morrissey P, Monaco A, Gohh R,Centracchio J, Dworkin L. Renal production ofhepatocyte growth factor increases after unilateralnephrectomy in man. Transplant Proc 2002; 34(8):3128-9.

• Yango A, Morrissey P, Zanabli A, Beaulieu J, SheminD, Dworkin L, Monaco A, Gohh R. Comparativestudy of prophylactic oral ganciclovir andvalacyclovir in high-risk kidney transplant recipients.Nephrol Dial Transplant 2003 Apr; 18(4): 809-13.

Douglas Shemin, M.D.• Shemin D, Bostom A, Laliberty P, Dworkin L. Residual

renal function and mortality risk in hemodialysispatients. Am J Kidney Dis 2001; 38: 85-90.

• Shemin D, Bostom AG, Selhub J. Treatment ofhyperhomocysteinemia in end stage renal disease. AmJ Kidney Dis 2001; 38 (supp 1): S91-S94.

• Shemin D. Early initiation of dialysis does not signi-ficantly increase survival in end stage renal disease. JEvidence Based Health Care 2002; 6: 89-90.

• Friedman AN, Bostom AG, Laliberty P, Selhub J,Shemin D. The effect of oral N-acetylcysteine on totalplasma homocysteine levels in chronic hemodialysispatients: a randomized, controlled, double blindstudy. Am J Kidney Dis 2003; 41: 442-446.

• Shemin D. Dialysis in Pregnant Women with ChronicKidney Failure. Accepted by Seminars in Dialysis.

Angelito Yango, M.D.• Yango A, Gohh R, Monaco A, Dworkin L, Butera J and

Morrissey P. Successful Treatment of Tacrolimus-Associated Thrombotic Microangiopathy withSirolimus Conversion and Plasma Exchange. ClinicalNephrology 2002; 58 (1), 77-8.

• Yango A, Morrissey P, Gohh R, Wahbeh A, Monaco A.Donor Transmitted Parvovirus Infection in a KidneyTransplant Recipient Presenting as Pancytopenia andAllograft Dysfunction. Journal of Transpl Infect Dis.2002 2(9): 872-6

• Morrissey PE, Ramirez PJ, Gohh RY, Yango A, KestinA, Madras PN, Monaco AP. Management ofThrombophilia in Renal Transplant Patients. Am JTransp 2002; 2 (9), 872-876.

• Yango A, Morrissey P, Zanabli A, Beaulieu J, Shemin D,Dworkin L, Monaco A, Gohh R. Comparative Study ofProphylactic Oral Gancyclovir and Valacyclovir inHigh Risk Kidney Transplant Recipients. NephrologyDialysis and Transplantation 2003; 18 (4) , 809-14.

• Yango A, Gohh R, Morrissey P, Centracchio J,Dworkin L. Renal Production of Hepatocyte GrowthFactor Increases after Unilateral Nephrectomy in Man.Transplantation Proceedings 2002; 34 (8), 3128-9.

N E P H R O L O G Y

BASIC RESEARCH

Lance Dworkin, M.D.

• Physiologic & Pathogenic Actions of Renal HGF/c-met,NIH/National Institute of Diabetes and Digestive andKidney Diseases

• Candesartan in Spontaneously Hypertensive Rats,Astra Pharmaceutical

CLINICAL RESEARCH

Andrew Bostom, M.D.

• Serum Total Homocysteine and C-Reactive Protein AsPred*, NIH/National Heart Lung & Blood Institute

• A Randomized Controlled Trial of Homocysteine,NIH/National Institute of Diabetes and Digestive andKidney Diseases

Andrew Brem, M.D.

• Pilot Study of Mycophenolate Mofetil in Childrenwith Steroid-Dependent Nephrotic Syndrome,Medical City Dallas Hospital

• Study of Blood Pressure Reduction with Fosinopril inChildren and Adolescents, Bristol-Myers Squibb,Incorporated

Lance Dworkin, M.D.

• Multicentered Randomized Double Blind PlaceboControlled Efficacy and Safety Study of the Effects ofOral Tolvaptan in Patients with Hyponatremia,Otsuka America Pharmaceutical Incorporated

• A Multi-Center Double Blind Randomized ParallelGroup Study to Evaluate the Effects of Diovan onMicroalbuminuria in Hypertensive Subjects withType 2 Diabetes Mellitus (DM), NovartisPharmaceutical Corporation

• Clinical Protocol for a Multi-Center Placebo Run-In,Randomized, Double-Blind Parallel Group Trial toEvaluate the Effects of Eplerenone vs. Eplerenone/Lisinopril in Patients with Renal Insufficiency,Pharmacia, Incorporated

• A Double Blind Multi-Center Randomized Placebo-Controlled Parallel Group Study of the Effects ofNebivolol on Safety and Efficacy in Patients With

Mild to Moderate Hypertension, BertekPharmaceuticals, Incorporated

• A Prospective Multinational Multicenter Double BlindRandomized Active Controlled Trial in Patients withEssential Hypertension to Compare the Effect ofValsartan 80 and 160 mg with or without the additionof Hydroclorothiazide, Once Daily to that ofAmlodipine 5 & 10mg Once Daily, With or Withoutthe Addition of Hydrochlorothiazide, onCardiovascular Morbidity and Morality, NovartisPharmaceutical Corporation

• Clinical Protocol for a Long-Term, Open Label Studyof the Safety and Efficacy of Eplerenone Protoco,Covance

• A Randomized Controlled Trial of MycophenolateMofetil in Patients with IgA Nephropathy, MedicalCity Dallas Hospital

• A Randomized, Placebo-Controlled, MulticenteredTrial Evaluating A) Alternative Day Prednisone B) FishOil Supplements in Young Patients with IGANephropathy, Medical City Dallas Hospital

• Antihypertensive Efficacy of Adding CandesartanCilexetil to Lisinopril in Comparison to Up-Titration,Astra Zeneca/OMNI

• Clinical Protocol for a Double-Blind RandomizedActive Controlled Comparison Study of theAntihypert, Covance, Incorporated, Searle

• The Effect of Irbesartan on Morbidity and Mortalityin Hypertensive Patients with Type II Diabetes andDiabetic Neuropathy, Bristol-Myers SquibbPharmaceutical Research

• A Multicenter, Randomized Double Blind ParallelGroup Study to Evaluate the Tolerability and Efficacyof the Co-Administration of Simvastatin 20 mg/dayand Fenofibrate 160 mg/day Compared to Simvastatin20 mg/day Alone for 12 Weeks of Treatment inPatients with Combined Hyperlipidemia, Merck & Co

• A Double Blind Randomized Placebo and ActiveControlled Parallel Group Dose Finding Study toEvaluate the Efficacy and Safety of Once Daily OralAdministration of 5mg, 10mg, 25mg, and 50mg ofM100240, Aventis Pharmaceuticals Products,Incorporated



Academic Year 2003 $205,795 $111,129 $316,924


Academic Year 2003 $2,346,628 $754,330 $3,100,958


Reginald Gohh, M.D.

• Rapamune Outcomes Assessment Registry, SyreonCorporation

• A Multicenter, Randomized, Open label Trial ofSimulect with Rapid Steroid Withdrawal vs Simulectwith Standard Treatment in Subjects Treated withNeoral and Cellcept for the Prevention of AcuteRejection in Renal Transplantation, DeaconessHospital

• An Open Label Multicenter Study to FurtherCharacterize the Clinical Utility and Safety ofRapamuneR, Wyeth-Ayerst Research

• A Comparative Open Label Study to Evaluate GraftFunction in De Novo Renal Allograft RecipientsTreated with Either a “Reduced Dose” or a “StandardDose” of Cyclosporine in Combination withRapamune (Sirolims) + Corticosteroids,Pharmaceutical Product Development

• A Randomized Open-Label Preference Study ofGengraf Compared to Neoral in Stable Solid-OrganTransplant, Pharmaceutical Product Development

• Pilot Study to Induce Specific Unresponsiveness withDonor-Specific Peripheral Blood Mobilized BoneMarrow Stem Cells (PBSCs) in Recipients of LivingDonor Mismatched Renal Allografts Treated withThymoglobulin and Standard Cyclosporine BasedImmunosuppression, Beth Israel Deaconess Medical

• Multicenter, Double-Blind, Randomized, ParallelGroup Study on Tolerability and Safety of ERL080A,Novartis Pharmaceuticals Corporation

Douglas Shemin, M.D.

• An Open Label Randomized Multicenter Phase IIIComparator Controlled Parallel Group Study toAssess the Long-Term Safety and Efficacy ofLanthanum Carbonate in Chronic Renal FailurePatients Receiving Hemodialysis, Rhode IslandClinical Research Center

• Disease/Case Management of Patients ReceivingAranesp (darbepoetin alfa) to Treat the Anemia ofChronic Renal Insufficiency (CRI), Amgen

• Correction of Hemoglobin & Outcomes in RenalInsufficiency (CHOIR), Carestat

• A Randomized Double Blind Parallel GroupEvaluation of Usual Care Plus Cervistatin 0.4mg,Once Daily, Bayer Corporation

• Mahurkar Triple Lumen Catheter, Tyco HealthcareGroup

O B S T E T R I C A N D C O N S U LTAT I V E M E D I C I N E

Karen Rosene-Montella, M.D., Professor of Medicine and OB/GYN;

Chief of Medicine and Director of Obstetric and Consultative

Medicine; Women & Infants Hospital

Overview

We are pleased to

announce that in July 2002, Dr.

Rosene was promoted to

Professor of Medicine and

Obstetrics & Gynecology, Brown

Medical School. From July 2002

to June 2003, the attending

physicians in the Division pre-

sented numerous abstracts at

conferences of the Society of

Obstetric Medicine and Society of

General Internal Medicine. Topics

of abstracts included: “Are women

making an informed decision

when they decline HIV testing

during pregnancy”, “The

prevalence of deep venous

thrombosis in women undergoing

cesarean section”, “What do

internists need to know in caring

for pregnant patients”, and “What

do obstetric internists get

consulted for?” They were also invited to give presenta-

tions at national and international conferences. Dr.

Rosene was Co-director at the American College of

Physicians Workshops on Medical Problems in

Pregnancy. She also presented a lecture at the Society of

Obstetric Medicine on Thrombosis and Throm-

bophilias in Pregnancy. Dr. Rosene was also Visiting

Professor and presented grand rounds on thrombosis in

pregnancy at King Edwards Women’s Hospital in Perth,

Western Australia. Additionally, she provided a demon-

stration about PIER - the Physicians’ Information

Education Resource at the Rhode Island Chapter ACP

Scientific Meeting, Revitalization of Internal Medicine.

Dr. Powrie’s presentations include: Depression in

Primary Care at the Advances in Medical Diagnosis and

Management Conference, Practi-Med 2002 held in

Tokyo, Japan. This conference was co-sponsored by the

New England Journal of Medicine and Harvard Medical

International. Dr. Powrie also gave presentations at the

Primary Care Internal Medicine: Principles and Practice

Course sponsored by Massachusetts General Hospital/

Harvard Medical School. Other presentations by Dr.

OBSTETRIC & CONSULTATIVE MEDICINE

Powrie include: Preventing Mother to Child Transmis-

sion of HIV. Faculty member at WHARF (Wockhardt-

Harvard Medical International HIV/AIDS Education

Foundation). Mumbai, India, Preventing Mother to

Child Transmission of HIV. Primary Care for People with

HIV Infection and AIDS. Presentation at Sion Hospital.

Mumbai, India, Preventing Mother to Child Transmis-

sion of HIV. Primary Care for People with HIV Infection

and AIDS. Presentation at JJ Medical School. Mumbai,

India, Medical Problems in Pregnancy: A review. Core

Curriculum Lecture Series, WIH, Thrombosis in Preg-

nancy, Visiting Professor Conference. Medical Society of

Delaware, Department of Obstetrics & Gynecology.

Christiana Care Health Services. Wilmington, DE,

Prescribing in Pregnancy. Residents and Medical Stu-

dents lecture, Department of Obstetrics & Gynecology.

Christiana Care Health, Prescribing in Pregnancy. Medi-

cal Grand Rounds. Department of Medicine. Christiana

Care Health Services/ Wilmington, DE, Keeping Current:

Hypertension in Pregnancy. Nursing Skills Day. WIH,

Diagnostic Imaging During Pregnancy. Family Medicine

Residency Program. Memorial Hospital of RI.


During the time of July 2001 through June 2002, the

attending physicians in the Division presented

numerous abstracts at conferences of the Society of

Obstetric Medicine and Society of General Internal

Medicine. Topics of abstracts included deep vein

thrombosis in women undergoing cesarean section,

hyperemesis, and syncope in pregnancy. They were also

invited to give presentations to Glendale Memorial

Hospital in California, Key Biscayne, FL, Christiana Care

Health Services in Delaware, and Harvard Medical

School in Boston. Topics of the presentations include

women and heart disease, prescribing in pregnancy,

curriculum in medical complications in pregnancy, and

medical problems during pregnancy. Grand Rounds

were presented at Charleton Memorial Hospital in Fall

River, Rhode Island Hospital, and Women & Infants

Hospital. Topics for grand rounds included asthma in

pregnancy, renal disease, and diabetes in pregnancy.

Doctors Rosene, Montella and Powrie served as Co-

directors at the Annual American College of Physicians

national meeting for the workshops on Medical

Problems in Pregnancy. In addition, Dr. Powrie served as

the Director of the International Debate on

Thrombophilia in Pregnancy Prophylaxis for the

International Society for the Study of Hypertension in

Pregnancy in Toronto.

Additionally, the physicians meet with medical students

and fellows weekly for Obstetric Medicine noon

conference as well as presenting lectures throughout the

rotation on medical problems in pregnancy.


Lucia Larson, M.D., Assistant Professor of Medicine andObstetrics & Gynecology

Raymond Powrie, M.D., Associate Professor of Medicineand Obstetrics & Gynecology

Karen Rosene Montella, M.D., Professor of Medicineand Obstetrics & Gynecology

VOLUNTEER FACULTY

Silvia Degli Esposti, M.D., Clinical Associate Professor

Christy Dibble, DO, Clinical Assistant Professor/Gastroenterology

Margaret Miller, M.D.

Rossana Moura, M.D.


Lucia Larson, M.D.• Reviewer for ACP-ASIM PIER module “Chronic

Stable Angina”


• Medical Problems in Pregnancy, University of RhodeIsland: Nurse Midwife Program, Oct. 2001

• Neurologic Disorders, Women & Infants Hospital,Resident Core Curriculum, 2001

• Caring for Women with Medical Problems duringPregnancy, SGIM New England Regional Workshop,Beth Israel Deaconess Medical Center, March 8, 2002

• Medical Problems in Pregnancy, University of RhodeIsland: Nurse Midwife Program, Nov. 2002.

Margaret Miller, M.D.Invited presentations:

• Metropolitan Life Insurance Company, Lunch andLearn Series, Menopause, October 5, 2001

• Strong women, strong hearts, October 27, 2001

Raymond Powrie, M.D.• Vice President, North American Society of Obstetric

Medicine 2002-present

• Executive Member, International Society of ObstetricMedicine, 2002-present

• Dean’s Teaching Excellence Award for exemplaryteaching in Clerkship in Ob/Gyn, Brown MedicalSchool, 2002

• Dean’s Teaching Excellence Award for exemplaryteaching in Bio 282-Human Growth & Reproduction,Brown Medical School 2002.

• Special Recognition for Teaching Award,Undergraduate Medical Education Teachingpresented by the Department of Medical Education,Women & Infants Hospital, 2002.

• Full-time Faculty Excellence-in-Teaching presentedby the Department of Medical Education, WIH, 2002.

• Special Recognition for Teaching Award presented bythe Residents, WIH, 2002.

• Outstanding Teacher in Obstetric Medicine Award,presented by Chief Residents, WIH, 2002.

• Chairman’s Award for Outstanding Teaching, RIH,2003.


• Rhode Island Monthly magazine. Voted one of RhodeIsland’s “Top Doctors for Women”, 2003.

• Master of arts ad eundem degree awarded by BrownMedical School, Board of Fellows, May 2001

• Treasurer, Society of Medicine, 2000 – 2002


• Depression in Primary Care. Presentation atAdvances in Medical Diagnosis and Management,Practi-Med 2002. Co-sponsored by New EnglandJournal of Medicine and Harvard MedicalInternational, Tokyo, Japan, September 15, 2002.

• Primary Care Internal Medicine. Principles andPractice Course 2002. Massachusetts GeneralHospital/Harvard Medical School, Department ofContinuing Education. Cambridge, MA. September30, 2002.

• Preventing Mother to Child Transmission of HIV.Faculty member at WHARF (Wockhardt-HarvardMedical International HIV/AIDS EducationFoundation). December 5-8, 2002, Mumbai, India.

• Preventing Mother to Child Transmission of HIV.Primary Care for People with HIV Infection andAIDS. Presentation at Sion Hospital. Mumbai, India.December 5-8, 2002, Mumbai, India.

• Preventing Mother to Child Transmission of HIV.Primary Care for People with HIV Infection andAIDS. Presentation at JJ Medical School. Mumbai,India. December 5-8, 2002, Mumbai, India.

• Medical Problems in Pregnancy: A review. CoreCurriculum Lecture Series, WIH, Jan. 17, 2003.

• Thrombosis in Pregnancy. Visiting ProfessorConference. Medical Society of Delaware,Department of Obstetrics & Gynecology. ChristianaCare Health Services. Wilmington, DE. January 22,2003.

• Prescribing in Pregnancy. Residents and MedicalStudents lecture. Department of Obstetrics &Gynecology. Christiana Care Health

• Prescribing in Pregnancy. Medical Grand Rounds.Department of Medicine. Christiana Care HealthServices, Wilmington, DE, January 23, 2003.

• Keeping Current: Hypertension in Pregnancy.Nursing Skills Day. WIH, April 28, 2003.

• Diagnostic Imaging during Pregnancy. FamilyMedicine Residency Program. Memorial Hospital ofRI. May 8, 2003.

Poster Presentation and Workshop Session:

• Development and Implementation of a Curriculumin Medical Complications in Pregnancy: OurExperience to Date, Council on Resident Education inObstetrics and Gynecology/Association of Professorof Gynecology and Obstetrics, Key Biscayne, FL,January 8, 2002

• Women and Heart Disease Conference, ChristianaCare Health Services, Cardiac Disease in Pregnancy,Wilmington, DE, February 16, 2002

• Diabetes in Pregnancy, Core Curriculum LectureSeries, Women & Infants Hospital, Providence, RI,March 8, 2002

• Best Beginnings Conference, Warwick, RI, March22, 2002

• Diabetes in Pregnancy, Core Curriculum LectureSeries, Women & Infants Hospital, Providence, RI,April 7, 2002

• Co-Director, Workshop on Medical Problems inPregnancy, Philadelphia, PA, April 2002

• Harvard Medical International: HMI-WockhardtLeadership Program for Nurse and HospitalAdministrators, Medical Safety, Boston, MA, April26, 2002

Karen Rosene Montella, M.D.• Deputy Editor, PIER (Physician’s Information and

Education Resource) American College ofPhysicians/American Society of Internal Medicine

Invited Presentations

• Bioterrorism Readiness Task Force, Women &Infants Hospital, 2001

• Director, International Debate on Thrombophilia inPregnancy Prophylaxis, International Society for theStudy of Hypertension in Pregnancy, Toronto,Canada. June 2002.

• Co-director, Workshop on Medical Problems inPregnancy, PA, April 2002

• Society of Obstetric Medicine, President 1997 – 2002

• Director, Workshops in Medical Complications ofPregnancy, American College of Physicians, SanDiego, CA. April 2003.

• Director, Workshop on Thrombophilias inPregnancy, American College of Physicians-American Society of Internal Medicine AnnualConference, San Diego, CA. April 3-5, 2003.

• Visiting Professor, King Edwards Women’s Hospital,Perth, Western Australia. Grand Rounds onThrombosis in Pregnancy. April 2003

• PIER Demonstration (Physicians’ InformationEducation Resource). Rhode Island ACP Chapter,Scientific Meeting. Revitalization of InternalMedicine. Warwick, RI. April 23, 2003.


Research and OtherScholarly ActivitiesThe Division’s interest in research is related to

pregnant women and medical complications of

pregnancy. Dr. Rosene’s interests lie in thrombosis in

pregnancy, specifically the prevention of pulmonary

embolism and deep venous thrombosis in preg-

nancy, A-gradient in pulmonary embolism in the

pregnant patient, the effect of heparin on bone

density in pregnancy, platelet activation in normal

and hypertensive pregnancy, and curriculum

development in medical consultation in pregnancy.

Dr. Powrie’s research interests include medical

consultation in pregnancy, and curriculum develop-

ment in medical consultation and obstetric

medicine. Dr. Larson’s research interests include

thrombophilias and recurrent spontaneous abor-

tions, education on medical problems in pregnancy,

palpitations in pregnancy, preeclampsia and toler-

ance to paternal antigens. Under the supervision of

Dr. Larson, Powrie and Rosene-Montella, the fellows

of the division have been very productive this past

year. Dr. Sia, Dr. Powrie, and Dr. Larson have

completed a 200 participant project examining the

incidence of deep venous thrombosis after cesarean

delivery. Dr. Sia (Fellow), Dr. Rosene Montella and

Dr. Powrie have completed a 1000 patient chart

review over a ten-year period to describe the con-

sults for which obstetricians seek the help of general

internists. Dr. Blackburn (Fellow) and Dr. Powrie are

half way through a 200 participant study examining

the use of spot urine protein to creatinine ratios as

compared to 24-hour urines to diagnose proteinuria

in the setting of suspected pre-eclampsia. Dr. Sauve

(Fellow) and Dr. Powrie are near completion of a

100 participant project looking at the use of

educational materials to help improve knowledge,

decrease anxiety, and improve compliance in

patients with suspected pre-eclampsia. The division

is also part of a multicenter, randomized trial,

looking at standard versus low molecular weight

heparin for thromboprophylaxis in pregnancy. The

division has also submitted its first RO3 grant this

year seeking funding for an expanded study looking

at the incidence of and risk factors for TED after

cesarean section.

FACULTY MEMBERS OF STUDY SECTIONS ANDADVISORY COMMITTEES

Lucia Larson, M.D.• Executive Committee of Society of Obstetric

Medicine

• Honorary Chairman, Physicians’ Advisory Board,National Republican Congressional Committee. 2002

Raymond Powrie, M.D.• Secretary/Treasurer Society of Obstetric Medicine

Karen Rosene Montella, M.D.• Editor, Journal of Obstetrics and Gynaecology

• Advisory Committee of the Department of Healthand Human Services (HHS)

• Consultant, Pregnancy Labeling Subcommittee of theReproductive Health Drugs Advisory Committee,Food & Drug Administration

• Executive Committee of the International Society ofObstetric Medicine

• State of Rhode Island, Department of HealthAdvisory Committee of the Office of Women’s Health

TEACHING ACTIVITIES

EDUCATION HONORS

Lucia Larson, M.D.• Obstetric Medicine Teaching Award, Women &

Infants Hospital, June 2002

• Dean’s Teaching Excellence Award for exemplaryteaching in Bio 282-Human Growth & Reproduction,Brown Medical School, 2002.

Raymond Powrie, M.D.• David E. Rogers Medical Education Award from the

Society of General Medicine for a workshoppresented in San Diego in April 2001

• Special Recognition Teaching Award for theworkshop “Medical Problems in Pregnancy for theMedical Care Provider” in November 2001 from theHarvard Medical School Primary Care Coursesponsored by the Massachusetts General Hospital



Lucia Larson, M.D.• BioMed 282, small group sessions

• Affinity Group, Alternative Medicine

• Biomed 340, Medical Consultation in Obstetrics&Gynecology

Raymond Powrie, M.D.• BioMed 282

• Affinity group

• Clerkships

• BioMed 490 Informal curriculum (literature andmedicine) session during ob/gyn & medicineclerkship

• Clinical years book club

CLINICAL ACTIVITIES

During the time of June 02 – May 03, the Division has

provided consultation to 2250 inpatients at Women &

Infants Hospital. The Division’s outpatient practice in

Internal Medicine & Obstetric Medicine consultation

provided care to 4651 patients, most of which were

consultations for the Ob/Gyn physicians.

Our clinicians see patients for such diagnoses as

thrombosis in pregnancy, cardiac disease in

pregnancy, headaches, palpitations, hypertension and

asthma. We often follow patients with chronic medical

problems throughout their pregnancy and also do

preoperative medical evaluations for patients

anticipating surgery. We also offer preconception

counseling for women with medical problems who are

considering pregnancy.


Carson MP, Powrie RO, Rosene-Motella K: SinusTachycardia in Pregnancy: A normal finding.American Journal of Obstetrics & Gynecology, in press.

Larson L, Rosene-Montella, K. ThromboembolicDisease in Women. In: Women’s Health in PrimaryCare. Vol. 3/May-June 2003.

Carson MP, Powrie RO, Rosene-Motella K: The effect ofobesity and position on heart rate in pregnancy.Journal of Maternal Fetal Medicine, 2002; 11:40-45.

Gibson PS, Rosene-Montella, K: Anticoagulants inPregnancy. Bailliere’s Clinical Obstetrics andGynaecology. In Press. November 2001.

Rosene-Montella K, Easterling T, Lee R: Treatment forChronic Mild to Moderate Hypertension inPregnancy. Journal of Obstetrics and Gynaecology.2001 Vol 21(4): 335-339.

Larson L, Rosene-Montella, K. ThromboembolicDisease in Women. In: Women’s Health in PrimaryCare. Vol. 3/May-June 2003.

Larson L. Treatment of Dysentery in a PregnantWoman. In: Cohen J, Powderly W, Eds. In: InfectiousDisease, 2e. Submitted in September 2002. In press.

Larson L. Neurologic Disorders - Multiple Sclerosis. In:Richard V. Lee, M.D., Karen Rosene-Montella, M.D.,Linda Anne Barbour, M.D., Peter R. Garner, MB andErin Keely, M.D., eds. Medical Care of the PregnantPatient. ACP Women’s Health Series. 1st ed.Philadelphia, PA; July 2000 Pp 692-700.

OBSTETRIC AND CONSULTATIVE MEDICINE FELLOWSHIP PROGRAMCurrent Fellows

Name Medical School Residency Post Graduate Plans

Winnie Sia, M.D. University of Alberta Internal Med. Residency Continuing Fellow,School of Medicine University of Alberta Graduating 6/03

To University of Alberta

Sonya Vora, DO Univ. of New England Internal Med. Residency Robert Wood JohnsonCollege of Osteopathic Univ. of Connecticut Hospital in New JerseyMedicine Graduated 6/02

Catherine Blackburn, M.D. University of Auckland Royal Australasian Continuing fellowSchool of Medicine College of Physicians

Nadine Sauve, M.D. Univ. of Sherbrooke Internal Med. Residency Univ. of SherbrookeUniversity of Sherbrooke


Rosene-Montella K, Larson L. Obstetric Monitoring:Maternal and Fetal Testing-Diagnostic Imaging inPregnancy. In: Richard V. Lee, M.D., Karen Rosene-Montella, M.D., Linda Anne Barbour, M.D., Peter R.Garner, MB and Erin Keely, M.D., eds. Medical Careof the Pregnant Patient. American College ofPhysicians Women’s Health Series. 1st ed.Philadelphia, PA; July 2000. Pp103-115.

Rosene-Montella, Barbour L, Larson L. PostpartumDisorders. In: Richard V. Lee, M.D., Karen Rosene-Montella, M.D., Linda Anne Barbour, M.D., Peter R.Garner, MB and Erin Keely, M.D., eds. Medical Careof the Pregnant Patient. American College ofPhysicians Women’s Health Series. 1st ed.Philadelphia, PA; July 2000. Pp805-823.

Miller M, Sauve N. Congestive Heart Failure in Women.In: Phyllis C. Leppert and Jeffrey F. Peipert, Eds.Primary Care for Women 2e. Lippincott Williams &Wilkins. Accepted for publication. January 2003.

Miller M. GI Drugs in Pregnancy and RheumatologicDrugs in Pregnancy. In: Karen Rosene- Montella, Ed.Drug Prescribing in Pregnancy. American College ofPhysicians. Submitted for publication. March 2003.

Miller M. Breastfeeding and Childhood Asthma andAllergies. The Integrative Medicine Consult. (4)Number 9. September 2002.

Electronic Peer-Reviewed Publications

Miller M, Wheeler C. Menopause and HormoneReplacement Therapy. American College ofPhysicians-Physicians Information and EducationResource (PIER) Project. An online electronicresource with evidence-based medical informationfor practicing physicians. Each module providesinformation with levels of evidence on prevention,screening, diagnosis, treatment and management,follow-up, and patient education. http://pier.acponline.org. 2000.

Michael P. Carson, Raymond O. Powrie, Karen Rosene-Montella. The Effect of Obesity and Position onHeart Rate in Pregnancy. Journal of Maternal-Fetaland Neonatal Medicine 2002, 11:40-45.

Powrie, Raymond O. Contributor: Cases 40-43; In:Medical Consultation Pearls. Eds: Donna L. Mercado,M.D., Gerald W. Smetana, M.D.. 2002, Hanley &Belfus, Inc.

Caron Zlotnick, Raymond O. Powrie. Book chapter:Domestic Violence Screening Among MedicalResidents. Is the Message Getting Through? Journal ofInterpersonal Violence. Vol. 16 No. 8. August 2001 pp841-845. Sage Publications.

Powrie RO, Rosene-Montella KA. Book chapter:Hypertension and Preeclampsia. In: Medical Care ofthe Pregnant Woman (American College of PhysiciansWomen’s Health Series) (Lee RV, Rosene-Montella K,Barbour L, Garner PR and Keely E, Eds). July 2000;pp 185-208.

Powrie RO, Rosene-Montella KA. Book chapter: AcuteLung Injury. In: Medical Care of the Pregnant Woman(American College of Physicians Women’s HealthSeries) (Lee RV, Rosene-Montella K, Barbour L,Garner PR and Keely E, Eds). July 2000; pp 397-411.

P U L M O N A R Y , C R I T I C A L C A R E & S L E E P M E D I C I N E

Sidney Braman, M.D., Professor of Medicine; Director, Division of

Pulmonary, Critical Care and Sleep Medicine

Overview2001-2002

This academic year has been

one of great achievement for the

Division of Pulmonary and Critical

care Medicine. In November, 2001

the Division Director, Dr. Sidney

Braman (Professor of Medicine) was

inaugurated as the President of the

American College of Chest

Physicians (ACCP), the largest

international organization of

physicians caring for diseases of the

chest. In addition, Dr. Sharon

Rounds (Professor of Medicine) was

elected as Secretary-Treasurer of the

American Thoracic Society (ATS).

The ATS is a highly respected

academic society with members

throughout the world. The annual

meeting attracts the best scientific

presentations on clinical and basic

science subjects of Pulmonary and

Critical Care Medicine. Her current

position automatically puts her on a

track to become President of the ATS

in four years. Also we were pleased

to learn that Dr Mitchell Levy

(Associate Professor of Medicine),

Director of Critical Care Services at

the Rhode Island Hospital has been named the 2002

recipient of the Crister Grevnik Memorial Award from

the Society of Critical Care Medicine for his work in

Ethics in Medicine. This year the Medical ICU of the

Rhode Island Hospital, under Dr Levy’s leadership was

named as one of the top 11 ICUs in the country by the

National Coalition on Health Care and the Institute

for Healthcare Improvement.

The academic year has been one of great change. Two

of our members have left Brown to assume prestigious

teaching positions at other institutions. Dr. Nicholas

Hill has been appointed Division Director at the Tufts

Medical School and Dr. Aidan O’Brien has been

appointed to the position of Consultant in the Irish

PULMONARY, CRITICAL CARE & SLEEP MEDICINE

Health System. The nurturing academic environment

at Brown has allowed these two faculty members to

advance their careers with these prestigious

appointments.

The Division is pleased to announce that we have

recruited Dr. Michael Stanchina from Harvard Uni-

versity to join the staff at the Rhode Island Hospital.

Dr. Stanchina studies various aspects of sleep disorder

breathing and will offer our division great depth in the

research arena. Also, Dr. Patricia Russo-Magno, a

former fellow in the Brown Division of Pulmonary

and Critical Care Medicine, has joined the clinical

faculty at the Memorial Hospital.


Our current Fellows have had a highly productive

year. In the New England Research Competition

among all of the programs in the New England

states, three finalists from our program were chosen

and, Dr. Radhika Verma won Third Prize in the

competition with her work entitled “The effect of

sleep apnea therapy on glycemic control of type II

diabetics”. This year, three of our fellows presented

their research at the ATS meeting in Atlanta Georgia.

The Division again participated in the National

Resident Matching Program for Pulmonary and Cri-

tical Care Medicine. We had one of the most success-

ful matches ever. Two of the fellows who matched

were from our Brown internal medicine residency

program. Two other fellows are now training at the

Beth Israel-Deaconess Hospital in Boston.

2002-2003

This academic year has been one of high national

and international profile for the division. Dr. Sharon

Rounds has assumed the position of president-elect

of the American Thoracic Society. At the same time

Dr. Sidney Braman has stepped down as president of

the American College of Chest Physicians and

assumed the role of immediate past president. Both

physicians have taken active roles in representing

their societies on a national and international level.

For example, both participated in a joint meeting of

the National College of Chest Physicians and Indian

Chest Society in Jaipur, India in November of 2002.

Both were keynote speakers at the meeting deliver-

ing honorary lectures to the nearly 2,000 partici-

pants at the meeting. They have been active in inter-

society relationships, dealing with the AMA and the

NIH on issues advocating for the pulmonary and

critical care physician. Dr. Braman attended the

AMA Leadership Conference in Chicago in 2002 and

Dr. Rounds was a member of the Scientific Advisory

Board for the Parker B. Francis Foundation fellow-

ship. She also served as a member of a study section

of the NHLBI and a reviewer for their loan repay-

ment program. Dr. Mitchell Levy was chairman of a

multisociety consensus conference and national

initiative in sepsis education in critical care. He is a

leader of the Surviving Sepsis Campaign, a patient

oriented program. He also served as a NIH panel

member for the ARDSNet. He serves on the Society

of Critical Care Medicine Executive Committee and

is a member of the Robert Wood Johnson consensus

group on managing death in the ICU. He is a mem-

ber of the American Thoracic Society Task Force on

End-of-life Care. Dr. Richard Millman is co-chair of

the joint NIH-American Academy of Pediatric Task

Force on Sleepiness in Adolescents and Young Adults.

He has been named to the American Thoracic Society

Audit and Finance Committee. Dr. Elizabeth

Harrington has served as a panel member of the

USAMRMC/CDMRP Breast Cancer Program and the

American Heart Association Northeast Research

Program.

Two new members of the division were recruited this

year. Dr. Muhanned Abu-Hijleh has joined the divi-

sion and will bring to this region, for the first time,

the credentials of an interventional pulmonologist. He

is a former fellow of the Brown program and

following his fellowship attended courses in Hemer,

Germany at the “Lungenklinik Hemer” with Dr. L.

Freitag. He has learned specialized techniques that

particularly pertain to problems of patients with

pulmonary malignancy. He will do medical thoraco-

scopy and a variety of rigid and flexible broncho-

scopic procedures that he has learned through his

additional training. Dr. Kevin Dushay is the second

new member of our division recruited this year from

a Brown search. He is a former fellow and faculty

member at the Beth Israel Deaconess Department of

Medicine. He then went to St. Vincent’s Hospital in

Worcester where for the last several years he has

served as a teaching attending in pulmonary and

critical care medicine. His research interests are in

critical care medicine and he will direct the

neurosurgical intensive care training program at

Rhode Island Hospital.

Two physicians this year were honored to be named to

the list of “America’s Top Doctors”. Dr. Sidney Braman

was named in pulmonology and Dr. Richard Millman

was named in pulmonology and sleep medicine.

The division continued to receive research recognition

in the way of external funding. Drs. Rounds, Klinger,

Harrington, Ward, Levy and Millman have all

successfully competed for external funding to support

the research activities of the division.

The division again participated in the National Resi-

dent Matching Program for pulmonary/critical care

medicine. We had another successful year with fellows

matched from our Brown program; Henry Ford

Hospital, Beth Israel Deaconess, and the Yale affiliated

Norwalk Hospital in New Haven, Connecticut.


Faculty MembersFULL-TIME FACULTY(Hospital or Foundation Based)

Muhanned Abu-Hijleh, M.D., Clinical AssistantProfessor of Medicine, Rhode Island Hospital,University Medicine Foundation

Alice Bonitati, M.D., Clinical Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Sidney Braman, M.D., Director, Professor, RhodeIsland Hospital, University Medicine Foundation

*E. Jane Carter, M.D., Assistant Professor, MiriamHospital, University Medicine Foundation

Vera DePalo, M.D., Associate Professor, MemorialHospital

Kevin Dushay, M.D., Assistant Professor of Medicine,(pending), Rhode Island Hospital, UniversityMedicine Foundation

Allan Erickson, M.D., Associate Professor, VA MedicalCenter

Elizabeth Harrington, Ph.D., Assistant Professor, VAMedical Center

Nicholas Hill, M.D., Professor, Rhode Island Hospital

Brian Kimble, M.D., Clinical Instructor, Rhode IslandHospital, University Medicine Foundation

Mallik Karamsetty, Ph.D., Assistant Professor, RhodeIsland Hospital

James Klinger, M.D., Associate Professor, VA MedicalCenter, University Medicine Foundation

Naomi Kramer, M.D., Clinical Assistant Professor,Rhode Island Hospital

Mitchell Levy, M.D., Associate Professor, Rhode IslandHospital, University Medicine Foundation

F. Dennis McCool, M.D., Professor, Memorial Hospital

Richard Millman, M.D., Professor, Rhode IslandHospital, University Medicine Foundation

Aidan O’Brien, M.D., Assistant Professor, VA MedicalCenter

Annie Lin Parker, M.D., Assistant Professor, MemorialHospital

Sharon Rounds, M.D., Professor, VA Medical Center

Michael L. Stanchina, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

Tihomir Stefanec, M.D., Assistant Professor, MemorialHospital

Eleanor Summerhill, M.D., Assistant Professor,Memorial Hospital

Nicholas Ward, M.D., Assistant Professor, RhodeIsland Hospital, University Medicine Foundation

*Joint Appointment in Infectious Disease

VOLUNTEER FACULTY

Darryl Adler, M.D., Clinical Assistant Professor,Memorial Hospital

Bernard Cieniawa, D.O., Clinical Instructor, FAHO

William Corrao, M.D., Clinical Professor, Rhode IslandHospital

R. William Corwin, M.D., Clinical Assistant Professor,Rhode Island Hospital

Walter Donat, M.D., Clinical Associate Professor, RhodeIsland Hospital

David Ettensohn, M.D., Clinical Associate Professor,Memorial Hospital

Ronald Gilman, M.D., Clinical Assistant Professor,Miriam Hospital

John Ladetto, M.D., Clinical Instructor, MemorialHospital

Daniel Lederer, M.D., Clinical Assistant Professor,Miriam Hospital

Curtis Mello, M.D., Clinical Assistant Professor, RhodeIsland Hospital

James Myers, M.D., Clinical Associate Professor, MiriamHospital

Linda Nici, M.D., Clinical Assistant Professor, RhodeIsland Hospital

Guy Settipane, M.D., Clinical Instructor, Rhode IslandHospital

Charles Sherman, M.D., MPH, Clinical AssociateProfessor, Miriam Hospital

Joseph Tarpey, M.D., Clinical Assistant Professor,Miriam Hospital

Joel Weltman, M.D., Ph.D., Clinical Professor, RhodeIsland Hospital

John F. Zwetchkenbaum, M.D., Clinical Instructor,Memorial Hospital

ADJUNCT FACULTY

Joseph Meharg, M.D., Adjunct Assistant Professor,Roger Williams Medical Center

Michael Passero, M.D., Adjunct Associate Professor,Roger Williams Medical Center



Name Former Position New Position

Nicholas Hill, M.D. Professor, Rhode Island Hospital Chief, Pulmonary, CriticalCare & Sleep Division,Tufts-New England Med. Ctr.

Aidan O’Brien , M.D. Assistant Professor, VA Medical Center Consultant in the Irish HealthSystem

Naomi Kramer, M.D. Assistant Professor, RIH Private Practice, Providence, RI

Mallik Karamsetty, Ph.D. Assistant Professor, RIH Relocated to South Carolina

Darryl Adler, M.D. Clinical Assistant Professor, Memorial Relocated to New York

Dana Crino, M.D. Clinical Assistant Professor, Memorial Mayo Clinic, Minnesota

New Faculty


Hospital or Foundation Based

Muhanned A. Abu-Hijleh, M.D. Pulmonary/Critical Care Fellow Clinical Assistant Prof. of Medicine

Brian A. Kimble, M.D. Fellowship RIH 2001-02 Clinical Instructor, RIH

Kevin M. Dushay, M.D. St. Vincent’s Hospital, U Mass Assist. Prof. of Medicine (pending)Med. School, Worcester, MA

Michael L. Stanchina, M.D. Brigham & Women’s Hospital Assistant Professor of Medicine

Tihomir Stefanec, M.D. Fellow, Cornell U, Memorial Assistant Professor of MedicineSloan-Kettering Cancer Ctr.

Private Practice

John Ladetto, M.D. Fellowship RIH 1998-01 Clinical Instructor, Memorial

Dana Crino, M.D. Fellowship Mayo Clinic 1998-2000 Clin. Assist. Prof., Memorial

Robert Westlake, M.D. Fellowship Harvard Medical Clin. Assist. Prof., MemorialSchool 7/98-6/01


Muhanned A. Abu-Hijleh, M.D.• Attended pulmonary interventional medicine courses

in Hemer, Germany at “Lungenklinik Hemer” withDr. L. Freitag in September 2002 and February 2003

Sidney S. Braman, M.D• Member, Board of Directors, Chest Foundation,

Northbrook, IL

• President, American College of Chest Physicians,November 2001 – November 2002

• Representative, American College of Chest Physiciansat the Capital Hill Caucus, Washington, DC

• Invited Participant in the American Medical Associa-tion 2002 Presidents’ Forum, Chicago, IL, July 2002

• Faculty in the American College of Chest PhysiciansBoard Review Course, Chicago, IL, August 2002

• Visiting Professor, University of Warsaw and PolishThoracic Society, Krakow, Poland, September 2002

• Member, National COPD Coalition, NationalInstitutes of Health

• Co-Chairman, ACCP Symposium Medical Innovationsvs. Cost Containment

• Member, Forum for International RespiratorySocieties Meeting, Geneva Switzerland, January 2002

• Member, Selection Committee, GSK PulmonaryFellowship Research Awards


• American College of Chest Physicians: Immediate PastPresident, Board of Regents and Executive Committee

• CHEST Foundation: Board of Trustees

• Member of the Faculty, ACCP Pulmonary BoardReview Course (August 2002)

• Pulmonary Fellowship GSK Research Awards—Selection Committee

• Member of the Editorial Board of SEEK - Selfassessment textbook published yearly by the ACCP(February 2003)

• Listed as one of “America’s Top Doctors” 2002


• The Young Leadership Symposium American College ofChest Physicians Annual Meeting, November 2001

• Asian-Pacific Congress on Diseases of the Chest,Bombay, India-Honorary Chairman and lecturer,November 2001

• Attended American College of Chest Physicians, Forumfor International Respiratory Societies Meeting,Geneva, Switzerland January 2002

• Society of Critical Care Medicine, San Diego, CA,January 2002

• Puerto Rican Thoracic Society, March 2002

• Co-Chair, 8th Annual Critical Care Update “Bench to Bed-side: Emerging Technologies”, Newport, RI, April 2002

• Chinese Thoracic Society, Beijing, China/Guangzhou,China, April 2002

• Hong Kong/Macau Thoracic Society/ACCP Chapter,April 2002

• Respiratory Symposium, Singapore, April 2002

• Meet-the-Professor Seminar, American ThoracicSociety, Atlanta, Georgia, May 2002

• American Association of Physicians of India AnnualMeeting, Chicago, IL, June 2002

• Tuscany Critical Care Society, Florence, Italy, June 2002

• 25th Anniversary Meeting Italian Chapter of the ACCP,Naples, Italy, June 2002

• Meet-the-Professor Seminar – Chaired Seminar“Medical Technology Vs Cost Containment” AmericanCollege of Chest Physicians - Annual InternationalMeeting, San Diego, CA, October 2002

• Brazil Thoracic Society Annual Meeting, Sao Paulo,Brazil, October 2002

• Combined Annual Meeting of the Indian Chest Societyand the National College of Chest, Jaipur, India,November 2002

• American College of Physicians-American Society ofInternal Medicine 2003 Annual Session, San Diego, CA,April 2003

• Meet-the-Professor Seminar, American ThoracicSociety, Seattle, WA, May 2003

Vera A. DePalo, M.D.• National Leadership Award, Honorary Co-Chairman,

RI, National Physician’s Advisory Board

• Rhode Island Medical Review Advisory Committee(2002-present)

• Governor, Rhode Island Chapter American College ofChest Physicians (2002-present)

• Board of Directors, American Lung Association., RIChapter (2002-present)

• Reviewer, CHEST, Journal of the American College ofChest Physicians (2002-present)

• Reviewer, Journal of the American Geriatric Society(2003-present)

• Society of Critical Care Medicine,ContinuingEducation Committee (2003-2006)

• American Thoracic Society, Membership Committee(2002-present)


• Rhode Island Society for Respiratory Care, AnnualConvention and Exhibition, April 2002

• 9th Annual Update. The New England Chapter-Societyfor Critical Care Medicine, April 2002

• Medical Grand Rounds, Memorial Hospital of RhodeIsland

• Rhode Island Society for Respiratory Care, AnnualMeeting




Elizabeth O. Harrington, Ph.D.• Panel Member, USAMRMC/ CDMRP Breast Cancer

Research Program, 2001

• Organizer, Research Seminar Series for the BrownUniversity Graduate Program in Pathobiology, 2000–2003

• Panel Member, American Heart Association,Northeast 5B Research Program, 2002

• Member, Committee on the Status of Women, BrownUniversity, 2002–2005

• Panel Member, American Heart Association,Northeast 5B Research Program, April 2003 Ad hocReviewer, Respiratory Physiology Study Section, NIHNHLB, June 2003

• Member, Committee on the Status of Women, BrownUniversity 2002-2005



• Surgical Research Seminar, Department of Surgery,Brown Medical School, October 2001

James R. Klinger, M.D.• Membership Committee, American Thoracic Society,

2002-2003

• Pulmonary Circulation Program Committee,American Thoracic Society, 2002-2003


• Medical Grand Rounds, Charleton MemorialHospital, New Bedford, MA, October 2001

• Society of Critical Care Medicine - Annual meeting,San Diego, CA, January 2002

• Society of Critical Care Medicine - Annual meeting,San Diego, CA, January 2002

• Research Conference, Tufts University/New EnglandMedical Center, May 2002

Mitchell M. Levy, M.D.• Presidential Citation Award, Society of Critical Care

Medicine, 2000, 2001

• Letter of Commendation, American College of ChestPhysicians, The CHEST Foundation, 2001, 2002

• Christer Grenvik Memorial Award for Ethics inCritical Care Medicine, Society of Critical CareMedicine, January 2002

• Rhode Island MICU (Director): National Coalitionon Health Care and the Institute for HealthcareImprovement, recognition as one of the top elevenICUs in the U.S. for exceptional quality of care,January 2002

• Senior Editor, Journal of Critical Care, W B Saunders,Philadelphia, PA 2001 - present

• Letter of Commendation, the CHEST Foundation,2001

• Council member, the governing body of the Societyof Critical Care Medicine, term 2/2002-2/2005

• Chair, Disease Management Summer Conference:joint effort between the Society of Critical CareMedicine and the European Society of Intensive CareMedicine for education and critical care, 2001


• National Initiative in Sepsis Education ConsensusConference, San Diego, CA, March 2001

• Medical Grand Rounds, “Sepsis 2001,” SUNYDownstate Medical Center, NY, August 2001

• Attending Rounds, Abbott Northwestern Medical,“Disease State of Sepsis,” Minneapolis, MN,September 2001

• Medical Grand Rounds, “Update on Management ofSepsis,” New York Hospital, Queens, NY, October2001

• Medical Grand Rounds, “Compassionate PalliativeCare in the ICU,” University of Pittsburgh,Pittsburgh, PA, October 2001

• American College of Chest Physicians: CHEST 2001,“Novel Approaches to the Treatment of Sepsis,Philadelphia, PA, November 2001

• National Initiative in Sepsis Education, Houston, TX,November 2001

• Grand Rounds, “New Developments in thePathophysiology and Management of Severe Sepsis,”St. Luke’s-Roosevelt Hospital Center, New York NY,November 2001

• Ethics Conference (keynote speaker), Paris, France,November 2001

• Sepsis Consensus Conference, Washington, DC,December 2001

• Surgical Grand Rounds, Stonybrook Hospital, LongIsland, NY, January 2002

• Regions Hospital, Grand Rounds, St. Paul, MN,January 2002

• 31st Critical Care Congress, Society of Critical CareMedicine, January 2002

• Infectious Disease Division, Buffalo, NY, February2002

• Western New York Pulmonary/Critical Care Society,Buffalo, NY, February 2002

• Internal Medicine Department, Buffalo GeneralHospital, Buffalo, NY, February 2002

• Sixth Annual Winter Oncology Conference, Whistler,British Columbia, Canada, February 2002

• Yale State Chest Conference, Yale/New Haven MedicalCenter, Yale University Medical School, New Haven,CT, February 2002

• Robert Wood Johnson ICU Peer Group for End-of-Life Care Meeting (Chair), Chicago, IL, February2002

• Brookdale Memorial Hospital, Patchogue, NY,February 2002

• 22nd International Symposium on Intensive Care andEmergency Medicine, Brussels, Belgium, March 2002

• Sepsis Legislative Breakfast, Washington, DC, April2002

• Co-Director, 8th Annual Critical Care Update, Benchto Bedside: Emerging Technologies in Critical CareMedicine, Newport, RI, April 2002

• 2002 National Initiative in Sepsis Education FacultyTraining Session, Phoenix, AZ, April 2002

• Critical Care Advisory Board, Boston, MA, May 2002

• JCAHO ICU Core Measure Advisory Panel, Chicago,IL, May 2002

• American Thoracic Society 2002, 98th InternationalConference, Atlanta, GA, May 2002


• Medical Grand Rounds, Dartmouth/HitchcockMedical Center, Lebanon, NH, May 2002

• Pulmonary Grand Rounds, Brookdale UniversityHospital, Brookdale, NY, June 2002

• National Initiative in Sepsis Education ConsensusConference, San Diego, CA, March 2001

• Sepsis Consensus Conference, Washington, DC,December 2001

• SCCM 2002 Disease Management SummerConference, Sepsis: Pathophysiologic Insights andCurrent Management, Boston, MA, Definitions ofSepsis Revisited: Results of the SCCM/ESICM/ACCP/ATS Consensus Conference; June 2002

• National Initiative in Sepsis Education Critical CareSymposium, Duke University/Raleigh-Durham, NC,July 2002

• Surviving Sepsis Campaign meeting, New York, NY,August 2002

• ARDSNet Panel (NIH), Chairman, Washington, DC,August 2002

• SCCM Executive Committee and Council Meeting,Chicago, IL, September 2002

• 15th Annual Congress European Society Critical CareMedicine, Barcelona, Spain New generation cardiacmonitoring: Principles, practice and performance;Sep/Oct 2002

• ACCP Chest 2002 Conference, San Diego, CA, NewGeneration Cardiac Monitoring: Principles, Practiceand Performance, November 2002

• NAPCON National Conference on PulmonaryDisease, Jaipur,INDIA, Mechanical Ventilation inARDS ; November 2002

• Westchester Medical Center, New York NY, MedicalGrand Rounds, November 2002

• Robert Wood Johnson/Promoting Excellence in End-of-Life Care NAC Site Visit Meeting, Princeton, NJ,November 2002

• National Initiative in Sepsis Education Critical CareSymposium, John Hopkins Hospital and HealthSystem, Baltimore, M.D., December 2002

• Surviving Sepsis Campaign initiative, New York, NY,December 2002 and Amsterdam, Netherlands,January 2003

• VHA Health Foundation Patient Safety Meeting,Providence, RI, December 2002

• Medical Grand Rounds, Newport Hospital, Newport,RI, December 2002

• 5th Annual Mechanical Ventilation and SleepConference: Today’s Breakthroughs for Tomorrow’sTreatment, Braintree, MA, High FrequencyVentilation; December 2002

• Grand Rounds, St. Luke’s/Roosevelt Hospital MedicalCenter, New York, NY, January 2003

• 32nd Congress Society of Critical Care Medicine, SanAntonio, TX, Early Goal Directed Therapy andManagement of the Septic Patient (Sepsis Treatmentand Management: An Evidence Based Review);Ethics: End-of-Life Care (End-of-Life Care in theICU: Strategies for Getting Better); New Data onCurrent Practices; New Developments in CuttingEdge Therapies (Surviving Sepsis Campaign); January2003

• Speaker Program and Medical Grand Rounds,Carolina’s Medical Center/Northeast Medical Center,Concord, NC, February 2003

• Bimonthly Department of Medicine Meeting, GoodSamaritan Hospital, West Islip, NY, February 2003

• 23rd International Symposium on Intensive Care andEmergency Medicine. Brussels, Belgium, March 2003

• International Consensus Conference in IntensiveCare Medicine/Challenges in End-of-Life Care in theICU, Brussels, Belgium, April 2003

• SCCM Council Meeting, Chicago, IL, May 2003

• Summit on ICU Quality and Cost/Chicago.Enhancing EOL Care in a Medical ICU ThroughComputer-Based Quality Improvement, May 2003

• Grand Rounds, New Jersey Medical School/UniversityHospital, May 2003

• American Thoracic Society International Conference,Seattle, WA. End of Life Decision Making. May, 2000.

• Value, Ethics, and Rationing in Critical Care TaskForce, Seattle, Washington, May 2003

• ESICM/SCMM 2nd Annual Summer Schoolconference. Conference Summarizer. Nice, France,June 2003

• New Definitions of Sepsis, Sicily, Italy, June 2003

• Surviving Sepsis Consensus Conference, Guidelinesfor Management of Sepsis,” London, England, June2003

F. Dennis McCool, M.D.• Board of Directors, American Lung Assoc. of Rhode

Island


• Mount Sinai Medical Center, New York, NY, July 2001

• American College of Chest Physicians, AnnualMeeting, Philadelphia, PA, November 2001

• Family Care Grand Rounds, St. Joseph Hospital,Providence, RI, February 2002

• SCI Research Rounds, VA Medical Center, Bronx, NY,May 2002

• Allergy/Immunology Grand Rounds, Brown MedicalSchool, Providence, RI, June 2002


Aidan D. O’Brien, M.D.• Secretary-elect, Rhode Island Thoracic Society, 2001-

2002


• American College of Chest Physicians AnnualMeeting, Chicago, IL, November 2001

• Grand Rounds, Upstate Medical Center, Syracuse, NY,November 2001

• Medical Grand Rounds, Limerick Regional Hospital,University of Limerick, Ireland, December 2001

Richard P. Millman, M.D.• Co-chair, Joint Task Force, National Center for Sleep

Disorders Research (NIH) and the AmericanAcademy of Pediatrics on sleep in adolescents andyoung adults

• Listed as one of “America’s Top Doctors”

• American Thoracic Society Audit and FinanceCommittee


• American Academy of Pediatrics Annual MeetingBoston, MA, October 2002

• Visiting Professor, North Shore - Long Island JewishHealth System, Manhasset, NY, March 2003

Committees

• Co-chair Joint NIH and American Academy ofPediatrics Task Force on Sleepiness in Adolescentsand Young Adults

Annie L. Parker, M.D.Invited Presentations:

• “Airway reactivity to methacholine is a minordeterminant of bronchodilator responsiveness,”Symposium on airway hyperresponsive, InternationalConference of the American Thoracic Society,Atlanta, GA, May 2002

• “Beta-agonist responsiveness after methacholine-induced bronchoconstriction is not affected byaging,” International Conference of the AmericanThoracic Society, Atlanta, GA, May 2002

• International Conference of the American ThoracicSociety. Seattle, WA. May 2003

Sharon Irene Smith Rounds, M.D.• Listed in “Best Doctors in America, Northeast

Region,” Woodward/White, 1994, 1998, 2002

• Associate Dean for Medical Faculty Affairs, BrownMedical School, 2001

• Member, Joint Workforce Coordinating Committeeof Committee on Pulmonary and Critical CareManpower (COMPACCS) for American ThoracicSociety, 1999-2001

• Chapter Representative, RI Thoracic Society, 2000-2001

• Member, Taskforce for Clinicians, American ThoracicSociety, 2000-

• Secretary-Treasurer, American Thoracic Society,2001-2002

• Vice-President, American Thoracic Society, 2002-03

• Elected Member, Medical Faculty ExecutiveCommittee, Brown University School of Medicine,1999-2001

American Thoracic Society:

• Vice-President, 2002-03

• Chair, Program and Budget Committee, 2002-03

• Member, Planning Committee, 2002-03

• Member, Audit and Finance Committee, 2002-03

• Chair, Audit and Finance Committee, 2003-04

• President-Elect, 2003-04

• Reviewer, Am J Molecular and Cell Physiology, 2003-

Liaison Committee on Medical Education, GeorgetownUniversity School of Medicine, February 23-26,2003

• Co-Chair, Search Committee for Director ofResearch, The Rhode Island Hospital, 2003-

• Chair, Search Committee for Chief of Pulmonary,Providence VA Medical Center, 2003-

• Member, Search Committee for the Director of theLeadership Alliance, Brown University, 2002

• Chair, Task Force for Review of the Charge of theCommittee on Medical Faculty Appointments, 2002-

• Member, Search Committee for the Chief of Staff,Providence VAMC, 2003-

• Chair, Search Committee for Associate Dean forClinical Faculty, 2002-03

• Chair, Search Committee for Associate Dean forWomen in Medicine, 2002-03


• FASEB Conference on Biological Methylation,Saxtons River, VT, July 2001

• Central Society for Clinical Research, Chicago, IL,September 2001

• Society for Critical Care Medicine, San Diego, CA,January 2002

• “Faculty Development Workshop,” Brown UniversitySchool of Medicine, March 2002

• National Coalition of 100 Black Women, Providence,RI, April 2002

• “The Status of Women Medical Faculty at Brown”,Senior Female Medical Faculty Meeting, BrownUniversity, June 2002

• FASEB Conference on Small GTPases and CellDynamics, Snowmass, Colorado, July 2002


• Grover Conference on Pulmonary Vascular Signaling,sponsored by American Heart Association, Deckers,Colorado, September 2002

• NAPCON conference, Jaipur, India, November 2002

• Pulmonary Research Conference, Tufts-New EnglandMedical Center, April 2003

• Invited Testimony for Friends of the VA before theHouse Subcommittee on VA, HUD, and IndependentAgencies Appropriations, April 2003

• Undergraduate Summer Research Day, BrownMedical School, July 200.

• Grantsmanship Workshop, Brown Medical School,January 2003

• Surgery Department Research Seminar, February 2003

• “Promotions: All you need to know aboutpromotions at Brown”, Workshop, Brown MedicalSchool, April 2003

Michael L. Stanchina, M.D.• Sleep Research Society - Research Trainee Award (2002)

Nicholas S. Ward, M.D.Invited Presentations:

• Rhode Island Hospital, Department of Medicine,Grand Rounds, July 2001

• Society of Critical Care Medicine AnnualInternational Educational and Scientific Symposium,speaker, Post-Graduate Review Course: Billing andCoding Management in the ICU, “The use ofElectronic Medical Records,” January 2002

• Society of Critical Care Medicine AnnualInternational Educational and Scientific Symposium,January 2002

• Brown Medical School 8th Annual Critical CareUpdate, April 2002

• European Society of Intensive Care Medicine/Societyof Critical Care Medicine, June 2002


Sidney S. Braman, M.D.• Abstract Reviewer, Fellowship Award Committee,

GSK Pulmonary Fellow Grant-in-Aid, February 2002

• Representative of the National Forum on ChronicObstructive Pulmonary Disease - NIH

Elizabeth O. Harrington, Ph.D.• Ad hoc Reviewer, American Journal of Physiology,

2001-2002

• Panel Member, USAMRC/ CDMRP Breast CancerResearch Program, 2001

• Organizer, Research Seminar Series for the BrownUniversity Graduate Program in Pathobiology, 2001-2003

• Panel Member, American Heart Association, Northeast5B Research Program, 2002

• Ad hoc Reviewer, Kidney International, 2002

• Member, Committee on the Status of Women, BrownUniversity, 2002-2005

James R. Klinger, M.D.• Steering Committee, INO Therapeutics, Comparison

of prostacyclin and nitric oxide for inhalation in theevaluation of reactivity of the pulmonary vasculatureduring acute pulmonary vasodilator testing

• American Thoracic Society – Writing committee,Position paper on inhaled nitric oxide in adult lungdisease, 2001

• Grant Reviewer, Florida Department of Health, Bio-medical Research Grants, Tampa Bay, May 3-4, 2001

Mitchell M. Levy, M.D.• Joint Commission on Accreditation of Healthcare

Organizations Intensive Care Unit (ICU) CoreMeasure 15-member Advisory Panel for developingcore measures for assessment of quality ICU care,March 2002 – present

• CHEST Annual Scientific Program, Annual College ofChest Physicians, 2001

• Advisory Board Member, National Initiative in SepsisEducation, December 2000 – present

Sharon Irene Smith Rounds, M.D.• Member, Scientific Advisory Board for the Parker B.

Francis Foundation Fellowships, Francis FamiliesFoundation, 2000-present


National Institutes of Health:

• Reviewer, Loan Repayment Program, NLHBI, 2002

• Member, Pulmonary IRG Study Section BoundariesTeam, NHLBI, October, 2002.

• Reviewer, Specialized Center for Clinical ResearchGrants, NHLBI, February 27-28, 2003.

• Reviewer, Loan Repayment Program, NHLBI, 2003.

Francis Families Foundation

• Member, Scientific Advisory Board for Parker B.Francis Foundation Fellowships, 2000-2003

TEACHING ACTIVITIES

EDUCATION HONORS

William M. Corrao, M.D.

• Excellence in Teaching Award, Brown Medical School,May 2002

Vera A. DePaolo, M.D.

• Dean’s Teaching Excellence Award, Brown MedicalSchool

Walter E. Donat, M.D.

• 2001 Chairman’s Award, Department of Medicine,Brown Medical School, May 2002

Allan D. Erickson, M.D.

• 2001 Chairman’s Award, Department of Medicine,Brown Medical School, May 2002

Annie L. Parker, M.D.

• Dean’s Teaching Excellence Award, Brown MedicalSchool,In recognition of exemplary teaching inBiomed 281: Pathophysiology

Sharon Irene Smith Rounds, M.D.

• Dean’s Teaching Excellence Award, 2001,2002

Nicholas S. Ward, M.D., FCCP

• Dean’s Teaching Excellence Award, Brown UniversitySchool of Medicine, 2001,2002


Alice E. Bonitati, M.D.• Attending Teaching Rounds: Pulmonary Consultation

Service and Respiratory Intensive Care Unit

• Elective 329 (Pulmonary Diseases) Teaching Attending

• Brown University Chest Conference

Sidney S. Braman, M.D.• Program Director, Pulmonary and Critical Care

Fellowship, Rhode Island Hospital

• Lecturer - Introductory Lecture Series for newpulmonary/critical care medicine fellows

• Lecturer - Housestaff Medical Noon Conference

• Attending Teaching Rounds - Pulmonary Consulta-tion Service and Respiratory Intensive Care Unit



E. Jane Carter, M.D.• Lecturer - Introductory Lecture Series for new

pulmonary/critical care medicine fellows

• Preceptor for the Tuberculosis Clinic (Pulmonary, infec-tious disease and pediatric Infectious disease fellows)

• Lecturer - Housestaff Conferences at Rhode IslandHospital, Miriam Hospital and the VA Medical Centeron tuberculosis


William M. Corrao, M.D.• Lecturer - Introductory Lecture Series for new


• Attending Teaching Rounds - Pulmonary ConsultationService and Respiratory Intensive Care Unit



Dana Crino, M.D.• Attending Teaching Rounds - Medical Intensive Care

Unit

• Medical Residents Noon Conference


• Biomed 301: Clerkship in Medicine: Preceptor andlecturer

Vera A. DePalo, M.D.• Lecturer - Introductory Lecture Series for new


• Lecturer - Critical Care Lecture Series at RIH

• Attending Teaching Rounds - Medical Intensive CareUnit

• Biomed 281: Pathophysiology: Lecturer and smallgroup leader; Director of the Pulmonary Section

• Biomed 301: Clerkship in Medicine: Preceptor andlecturer

• Biomed 337: Intensive Care Medicine (PMH): Director


Walter E. Donat, M.D.• Lecturer - Introductory Lecture Series for new



• Attending Teaching Rounds - Pulmonary ConsultationService and Respiratory Intensive Care Unit

• Elective 329 (Pulmonary Diseases) TeachingAttending


Allan Erickson, M.D.• Attending Teaching Rounds - Internal Medicine

Service, Pulmonary Consultation Service and MedicalIntensive Care Unit


• Site Director for Medical Residency Program at theVAMC

• Lecturer - Medical Noon Conference


• Biomed 281 Pathophysiology - Course Director(Small group section leader)

• Medicine Clerkship at the VAMC—Preceptor, CaseBook Discussant and Leader of Chest RadiologyConference Series

Elizabeth O. Harrington, Ph.D.• Lecturer - Biomed 285: Research Topics in

Pathobiology ( Seminar)

James R. Klinger, M.D.• Lecturer - Introductory Lecture Series for new


• Lecturer - Critical Care Lecture Series


• Attending Teaching Rounds - Medical Intensive CareUnit, Pulmonary Consultation Service andRespiratory Intensive Care Unit.

• Electives 329 & 334 (Pulmonary Diseases and MedicalIntensive Care) Teaching Attending


Mitchell M. Levy, M.D.• Lecturer - Introductory Lecture Series for new


• Attending Teaching Rounds - Medical Intensive CareUnit


• Elective 334 (Medical Intensive Care) TeachingAttending

• Medical Informatics - Teach medical skills to allInternal Medicine housestaff; introduce clinicalinformation systems in the ICU to all housestaff;teach severity scoring and automated data entry tohousestaff and medical students

• Ethics Lectures - MICU ethics conference everymonth coordinated with nursing Leadership

F. Dennis McCool, M.D.• Lecturer - Introductory Lecture Series for new


• Attending Teaching Rounds - PulmonaryConsultation Service


Aidan D. O’Brien, M.D.• Lecturer - Introductory Lecture Series for new



• Attending Teaching Rounds -Pulmonary ConsultationService and Medical Intensive Care Unit



Richard P. Millman, M.D.• Lecturer - Introductory Lecture Series for new



• Attending Teaching Rounds - PulmonaryConsultation Service, Medical Intensive Care Unitand Respiratory Intensive Care Unit



Annie L. Parker, M.D.• Lecturer - Introductory Lecture Series for new


• Lecturer - Biomed 281: Pulmonary Pathophysiology

• Small Group Leader - Biomed 281: PulmonaryPathophysiology

• Presenter at Noontime Teaching Conference

• Attending Teaching Rounds - PulmonaryConsultation Service and Medical Care Unit


Sharon Irene Smith Rounds, M.D.• Attending Teaching Rounds - Internal Medicine

Service, Pulmonary Consultation Service, andMedical Intensive Care Unit



• Lecturer - Biomed 285: Research Topics inPathobiology (Seminar)

Tihomir Stefanec, M.D.• Attending Teaching Rounds - Pulmonary Consultation

Service


Eleanor Summerhill, M.D.• Lecturer - Introductory Lecture Series for new


• Lecturer - Critical Care Lecture Series at RIH

• Attending Teaching Rounds - Pulmonary Consulta-tion Service and Medical Intensive Care Unit

• Lecturer - Biomed 282: Pathophysiology - Smallgroup leader

• Series of teaching lectures to third-year students atMemorial Hospital



Nicholas S. Ward, M.D.• Associate Program Director, Brown University School

of Medicine, Department of Pulmonary, Critical Care,and Sleep Medicine, 2001Lecturer - IntroductoryLecture Series for new pulmonary/critical caremedicine fellows



• Attending Teaching Rounds: Pulmonary ConsultationService, Medical Intensive Care Unit and Respiratory In-tensive Care Unit teaching fellows, residents and students


• Elective 334 (Medical Intensive Care) TeachingAttending


• Curriculum Committee, Brown University School ofMedicine, Chair of subcommittee on knowledge baseassessment, 2001

• 2002-present – Brown School of Medicine, InternalMedicine Residency Curriculum Committee.

Robert Westlake, M.D.• Attending Teaching Rounds - Medical Intensive Care

Unit


• Medical Residents Noon Conference

• Pulmonary & Critical Care Medicine Fellowship

PULMONARY FELLOWSHIP PROGRAMDeparting Fellows

Name Medical School Residency Post Graduate PlansMuhanned A. Abu- University of Jordan Brown Medical School Currently attending physician at RIHHijleh, M.D. Internal Medicine (MEM) and doing further study in interven-

tional pulmonology

Nadia Angov, M.D. University of Maryland York Hospital, York, PA Currently in practice at AtlanticGeneral Hospital, Berlin, M.D.

Bilal K. Chaudhry, M.D. Albany Medical College Crozer Chester Currently in private practice inMedical Center, Upland, PA Lancaster, PA

Ravi Desai, M.D. SUNY Buffalo SUNY Buffalo Currently doing a one-year criticalcare fellowship at the University ofRochester, Rochester, NY

Kristina Kramer, M.D. Medical College of PA Brown Medical School Currently in private practice inInternal Medicine (MEM) Walnut Creek, CA

Timothy N. Liesching, SUNY Buffalo Beth Israel Deconess Currently in private practice inM.D. Medical Center Pawtucket, RI

Obeidah Masoudi, M.D. University of Jordan Brown Medical School Will be returning to Jordan toInternal Medicine (MEM) practice pulmonary/critical care/sleep medicine

Ioana R. Preston, M.D. Carol Davila School Brown Medical School Currently affiliated with Tuftsof Medicine Internal Medicine (RIH) New England Medical Center

Radhika Verma, M.D. Lady Hardinge Medical St. Mary’s Health Center, Currently in private practice inCollege St. Louis, MO Orlando, FL

Current Fellows

Name Medical School ResidencyJason Aliotta, M.D. Tufts University Beth Israel Deaconess Medical Center

Nadia Angov, M.D. University of Maryland York Hospital, York, PA

Michael Baram,M.D. Jefferson Medical College Christiana Care Health System, Newark, DE

Gerardo Carino, M.D. Brown University Brown Medical School (RIH) – Internal Medicine

Ravi K. Desai, M.D. SUNY Buffalo SUNY Buffalo

Charles Lee, M.D. Jefferson Medical College Brown Medical School (RIH) – Internal Medicine

Timothy N. Liesching, M.D. SUNY Buffalo Beth Israel Deaconess Medical Center

Obeidah M. Masoudi, M.D. King Edward Medical College Brown Medical School (MEM) – Internal Medicine

Michael J. Ryan, M.D. Medical College of VA Medical College of VA

Daniel F. Sousa, M.D. University of VT Brown Medical School (RIH) – Internal Medicine

Radhika Verma, M.D. Lady Hardinge Medical College St. Mary’s Health Center, St. Louis, MO



Muhanned A. Abu-Hijleh, M.D.• Stone C, Nolan S, Abu-Hijleh MA, McCool FD, Hill

NS. A novel form of manually assisted ventilation.Chest 2003; 123(3):949-52.

• Parker AL, Abu-Hijleh MA. Clinical parameters arepoor selection criteria for the use of methacholineairway hyper-responsiveness in symptomatic subjects.Respir Care 2003; 48(6):596-601.

• Parker AL, Abu-Hjileh MA, McCool FD. FEF25-75/FVC ratio is a determinant of airway reactivity andsensitivity to methacholine. Chest (in press).

Sidney S. Braman, M.D.• Braman SS. Asthma in the elderly. Clin Geriatr Med

2003; 19:57-75.

Vera A. DePalo, M.D.• DePalo VA, McCool FD. The respiratory evaluation of

patients with neuromuscular disease. Semin RespirDis 2002; 23(3):201-9.

• DePalo VA, Iacobucci R, Crausman RS. Hospitalstratification of care forms in the state of RI. Am JCrit Care 2003; 12:239-41.

Elizabeth O. Harrington, Ph.D.• Bellas RE, Harrington EO, Sheahan KL, Newton J,

Marcus C, Rounds S. FAK blunts adenosine/homocysteine-induced endothelial cell apoptosis:Requirement for PI 3-kinase. Am J Physiol Lung CellMol Physiol 2002; 282:L1135-L42.

• Hai C-M, Hahne P, Harrington EO, Gimona M.Conventional PKC mediates phorbol dibutyrate-induced cytoskeletal remodeling in A7r5 smoothmuscle cells. Exp Cell Res 2002; 280:64-74.

• Kramer K, Harrington, EO, Bellas R, Sheahan KL,Newton JL, Rounds S. Methyltransferase inhibitionenhances apoptosis of pulmonary artery endothelialcells. Mol Biol Cell 2003; 14:848-57.

• Harrington EO, Brunelle JL, Shannon CJ, Kim ES,Mennella K, Rounds S. Role of PKC isoforms in ratepididymal microvascular endothelial barrierfunction. Am J Respir Cell Mol Biol 2003; 28:626-36.

James R. Klinger, M.D.• Klinger JR, Warburton R, Pietras L, Oliver P, Fox J,

Smithies O, Hill NS. Targeted disruption of the genefor natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. Am J Physiol 2002;282:H58-65.

• Preston IR, Klinger JR, Mehta S, Hill NS Pulmonaryedema in scleroderma patients given inhaled nitricoxide. Chest 2002; 121:656.

• Ward NS, Lin DY, Nelson DL, Houtchens J, SchwartzWA, Klinger JR, Hill NS, Levy MM. Successfuldetermination of lower inflection point and maximalcompliance in a population of patients with acuterespiratory distress syndrome. Crit Care Med 2002;30:963-68.

• Karamsetty M, Klinger JR. NO: more than just avasodilator in lung transplantation. Am J Resp CellMol Bio 2002; 26:1-5.

• Klinger JR. Inhaled nitric oxide for the treatment ofARDS. Crit Care Clin 2002; 18:45-68.

Mitchell M. Levy, M.D.• Cook DJ, Guyath G, Rocker G, Sjokvist P, Weaver B,

Dodek P, Marshall J, Leasa D, Levy MM, Varon J,Fisher M, Cook R, for the Canadian Critical CareTrial Group. Cardiopulmonary resuscitationdirectives on admission to intensive care unit: aninternational observational study. The Lancet 2002;358(9297):1941.

• Ward NS, Lin DY, Nelson DL, Houtchens J, SchwartzWA, Klinger JR, Hill NS, Levy MM. Successfuldetermination of lower inflection point and maximalcompliance in a population of patients with acuterespiratory distress syndrome. Crit Care Med May2002;30(5):963-68.

• Corwin HL, Gettinger A, Pearl RG, Fink MP, LevyMM, Shapiro MJ, Corwin MJ, Colton T. Efficacy ofrecombinant human erythropoietin in critically illpatients: a randomized controlled trial. JAMA. 2002Dec 11;288(22):2827-35.

• Levy MM, Fink MP, M.D., Marshall JC, Abraham E,Angus D, Cook D, Cohen J, Opal S, Vincent J-L,Ramsay G (For the International Sepsis DefinitionsConference). 2001 SCCM/ ESICM/ACCP/ATS/SISInternational Sepsis Definitions Conference. Co-published Int Care Med (2003)29:530-38; and CritCare Med 2003, Vol. 31, No.4

• Ryan M, Levy MM. Clinical Review: Fever in intensivecare unit patients. Crit Care 2003;7:221-25.

• Levy MM, Fink M, Marshall J, Abraham E, Angus D,Cook D, Cohen J, Opal S, Vincent J-L, Ramsay G, forthe International Sepsis Definitions Conference.2001 SCCM/ESICM/ACCP/ATS/SIS InternationalSepsis Definitions Conference. Crit Care Med 200331(4): 1250-1256.

F. Dennis McCool, M.D.• Parker AL, McCool FD. Pulmonary function

characteristics in patients with different patterns ofmethacholine airway hyperreactivity. Chest 2002; 121:1818-23.

• DePalo VA, McCool FD. The respiratory evaluation ofpatients with neuromuscular disease. Semin RespirDis 2002; 23(3):201-9.


• Stone C, Nolan S, Abu-Hijleh MA, McCool FD, HillNS. A novel form of manually assisted ventilation.Chest 2003; 123(3):949-52.

• Parker AL, Abu-Hijleh MA, McCool FD. FEF25075/FVC ratio is a determinant of airway reactivity andsensitivity to methacholine. Chest (in press).

Richard P. Millman, M.D.• Millman, RP (Editor), Sleep Disorders Issue,

Medicine & Health/Rhode Island 2002; 85:81-100.

• Stanchina M, Millman RP. Sleep Medicine in MSKAP13, American College of Physicians 2003.

Annie L. Parker, M.D.• Parker AL, McCool FD. Pulmonary function

characteristics in patients with different patterns ofmethacholine airway hyperreactivity. Chest 2002; 121:1818-23.

• Parker AL, Abu-Hijleh M. Clinical parameters arepoor selection criteria for the use of methacholineairway hyperresponsiveness in symptomatic subjects.Respir Care 2003; 48(6): 596-601.

• Parker AL, Abu-Hijleh MA, McCool FD. FEF25075/FVC ratio is a determinant of airway reactivity andsensitivity to methacholine. Chest (in press).

Sharon Rounds, M.D.• Bellas R, Harrington EO, Sheahan KL, Newton J,

Rounds S. Over-expression of focal adhesion kinaseprotects against adenosine/homocysteine-inducedapoptosis. Am J Physiol. Lung Cell Mol Physiol 2002;282:L1135-42.

• Kramer K, Harrington EO, Bellas R, Newton J,Sheahan KL, Rounds S. Isoprenylcysteine carboxylmethyltransferase activity modulates endothelial cellapoptosis. Mol Biol Cell 2003; 14:848-57.

• Harrington EO, Brunelle JL, Shannon CJ, Kim ES,Mennella K, Rounds S. Role of PKC isoforms in ratepidydimal microvascular endothelial barrierfunction. Am J Respir Cell Mol Biol 2003; 28:626-36.

• Poppas A, Rounds S. Congestive heart failure. Am JResp Crit Care Med 2002; 165:4-8.

• Rounds S, Klinger JR. Pulmonary Hypertension—Pathophysiology and Clinical Disorders. Textbook ofPulmonary Diseases. seventh edition, Ed by J Crapo, JGlassroth, J Karlinsky, and T King, Jr.

Michael L. Stanchina, M.D.• Stanchina ML, Tantisera KG, Aquino S, Wain JC,

Ginns LC. Unilateral predominance of scintillationscan defects and survival in cystic fibrosis patientsawaiting lung transplantation. J Heart LungTransplant 2002; 21:217-25.

• Stanchina ML, Malhotra A, Fogel RB, Ayas N,Edwards JK, Shory K, White DP. Upper airway muscleresponsiveness to chemical and mechanical loadingduring NREM sleep. Am J Respir Crit Care Med 2002;165:945-49.

• Stanchina ML, Malhotra A, White DP. Diagnosis andtreatment of respiratoty disorders of slpeep.Textbook of Pulmonary Diseases. In press. Crapo,Schwartz, King, Karlinsky (editors).

Nicholas S. Ward, M.D.• Ward NS, Lin DY, Nelson DL, Houtchens J, Schwartz

WA, Klinger JR, Hill NS, Levy MM. Successfuldetermination of lower inflection Point and MaximalCompliance in a Population of Patients with ARDS,Crit Care Med 2002; 30(5):963.

• Ward NS, Hill NS. Pulmonary function testing inpatients with neuromuscular disease, G. Chuppeditor. In Clinics in Chest Medicine. 2002 W.B.Saunders, Philadelphia 769-81.

• Ward NS, O’Brien A. End-of-life issues in thecritically ill, Medicine and Health Rhode Island 2002;85(2):60-2.

• O’Brien A, Ward NS. Inhaled corticosteriods inCOPD, Medicine and Health Rhode Island 2002;85(2):52-5.

• Ward NS. The effects of prone positioning in ARDS:an evidence based review of the literature, M.M. Levyeditor. In Critical Care Clinics 2002. W.B. Saunders,Philadelphia.

• Ward NS, Levy MM. Titrating optimal PEEP at thebedside: where are we now? In J.L.Vincent editor.Yearbook of Intensive Care and EmergencyMedicine.2002; Springer-Verlag, Berlin.



Total Basic Research Expenses Academic Year 2002 $998,382 $189,713 $1,188,095

Academic Year 2003 $460,310 $115,078 $575,388


Academic Year 2003 $540,708 $334,351 $875,059

BASIC RESEARCH

Elizabeth Harrington, Ph.D.

• Endothelium Barrier Function Modulation byPKCdelta, National Institutes of Health

Nicholas Hill, M.D.

• Natriuretic Peptides and the Lung, NIH/NationalHeart Lung & Blood Institute

Mallik Karamesetty, Ph.D.

• Phytoestrogens Attenuate Hypoxia-InducedPulmonary Hypertension, American HeartAssociation

James Klinger, M.D.

• Chronic Lung Disease, Cor Pulmonale, andNatriuretic Peptides, American Heart Association

• Mechanisms of Hypoxia-Induced Natriuretic PeptideSecretion in the Isolated Rat Heart, American HeartAssociation

Sharon Rounds, M.D.

• Rho and Ras GTPase and Lung EndothelialApoptosis, National Institutes of Health

• Focal Adhesion Complexes and Lung EndothelialApoptosis, National Institutes of Health

• Short Term Training for Minority Students, NationalInstitutes of Health

• Rho and Ras GTPase and Lung Endothelial CellFunction, National Institutes of Health

CLINICAL RESEARCH

Sidney Braman, M.D.

• A Double Blind, Randomized Multicenter ParallelGroup Study of Levalbuterol in the Treatment ofSubjects With Chronic Obstructive PulmonaryDisease, Sepracor/Parexel

• A Randomized Double Blind Placebo ControlledParallel Group Trial Assessing Rate of Decline ofLung Function with Tiotropium 18 Mcg CapsuleOnce Daily in Patients with Chronic ObstructivePulmonary Disease (COPD), Boehringer Ingelheim

• A Comparison of Ipratropium Bromide/SalbutamolDelivered by the Respimat Inhaler to IpratropiumBromide Respimat, COMBIVENT Inhalation Aerosoland Placebo for Each Formulation in a 12 WeekDouble Blind Safety and Efficacy Study in AdultsWith Chronic Obstructive Pulmonary Disease,Boehringer Ingelheim

• A 24 Week Randomized Double Blind PlaceboControlled Parallel Group Study to Evaluate theEfficacy, Smith Kline Beecham Pharmaceuticals

• Montelukast Sodium (SINGULAIR) Use In PatientsWith Stable COPD and Mild Asthma, Merck ResearchLaboratories

• Bronchopulmonary Pharmacokinetic andPharmacodynamic Profile of Moxifloxacin,Levofloxacin and Azithromycin in Adults UndergoingDiagnostic Bronchoscopy, Bayer Corporation

Vera DePalo, M.D.

• International Trial of Platelet Activating FactorAcetylhydrolase in the Treatment of Severe Sepsis,ICOS Corporation

Nicholas Hill, M.D.

• An International Multicenter, Uncontrolled, IPenEvaluation of Chronic UT-15 Plus ConventionalTherapy, United Therapeutics

• A Randomized Double Blind Placebo ControlledSafety and Efficacy Study of Sitaxsentan SodiumTreatment, OCOS-Texas Biotechnology


• A Phase II Multicenter Randomized Double-BlindPlacebo-Controlled Parallel-Group Dose-RangingEvaluation, Suntory Pharmaceuticals Incorporated/PPD

James Klinger, M.D.

• A Phase 3 Study to Demonstrate the Safety andEfficacy of Recombinant Platelet-Activating FactorAce Inhibitor, ICOS Corporation/PPD

• Development of a Hospital Based Program for theUse of Nitric Oxide for Inhalation in the ChronicManagement of Severe Cardioplulmonary Diseases,INO Therapeutics Incorporated

• Pulmonary Hemodynamic Effects of B-TypeNatriuretic Peptide Infusion in Patients WithPulmonary Arterial Hypertension, Scios Nova,Incorporated

Mitchell Levy, M.D.

• ICU Peer Group for End-Of-Life Care, Robert WoodJohnson Foundation

• An Open-Label Study of Recombinant HumanActivated Protein C in Severe Sepsis, Eli Lilly andCompany

• Multicenter Double Blind Placebo ControlledRandomized Phase III Study of TifacoginRecombinant Tissue, Chiron Corporation

• Efficacy and Safety of r-HuEPO in the Critically IllPatient: A Randomized Double-Blind PlaceboControlled Trial, Ortho Biotech

• Measuring the Quality of End-Of-Life Care in theIntensive Care Unit, Robert Wood JohnsonFoundation

• Increasing Organ Donation by Enhancing End-of-Life Care: A Family-Centered Quality ImprovementProgram, Education Development Center

Dennis McCool, M.D.

• Anabolic Therapies: New Hope for Treating theSecondary Disabilities of SCI, VA Merit Review

• Stage Based Health Promotion with the Elderly,National Institutes of Health

Richard Millman, M.D.

• Awake Chaotic Breathing Patterns as a Predictor ofObstructive Sleep Apnea, Vanguard Technologies,LLC

• Motivating Adherence to CPAP in Obstructive SleepApnea, Brown University

• Randomized Double Blind placebo ControlledParallel Multi Center Trial Comparing the Effects ofOrally Administered Xyrem (Solium Oxybate) withPlacebo for the Treatment of Narcolepsy, OrphanMedical Incorporated

• Sleep Apnea in Show Participants, University ofPennsylvania/nhlbi

Aidan O’Brien, M.D.

• Bronchopulmonary Pharmacokinetic and Pharma-codynamic Profile of Moxifloxacin, Levofloxacin andAzithromycin in Adults Undergoing DiagnosticBronchoscopy, Bayer Corporation

Eleanor Summerhill, M.D.

• A Two-Year, Multi-Site Family Study to Identify theGenetic Determinants Associated with Susceptibilityto Chronic Obstructuve Pulmonary Disease,GlaxoSmithKline

R H E U M AT O L O G Y

Stuart T. Schwartz, M.D., Clinical Assistant Professor of Medicine; Director, Division of Rheumatology

Overview

The Division of Rheumatology is involved

primarily in clinical activities, diagnosing and treating

patients with rheumatic diseases including arthritis

and connective tissue diseases. The Division also

participates in clinical research including the RADIUS

trial, a prospective observational outcomes trial of

patients with rheumatoid arthritis. Educational

activities included noon conferences and medical

grand rounds on subjects relating to rheumatic

diseases. In September 2002, Dr. Wendy Silversmith

joined the rheumatology division as a full time

attending. Her patient care responsibilities include an

out patient practice, precepting in the rheumatology

clinic and seeing hospital consults. Her teaching

responsibilities include the Brown Medical school

pathophysiology course and housestaff conferences at

Rhode Island Hospital.

RHEUMATOLOGY

Faculty MembersFULL TIME FACULTY(Hospital or Foundation Based)

• Stuart Schwartz, M.D., Director, Clinical AssistantProfessor, Rhode Island Hospital, UniversityMedicine Foundation

• Wendy Silversmith, M.D. Clinical Instructor, RhodeIsland Hospital, University Medicine Foundation

VOLUNTEER FACULTY

• Yousaf Ali, M.D., Clinical Instructor, Rhode IslandHospital

• John Conte, M.D., Clinical Assistant Professor, RhodeIsland Hospital

• Faiza Estrup, M.D., Ph.D., Clinical AssociateProfessor, Memorial Hospital

• Harold Horwitz, M.D., Clinical Assistant Professor,Miriam Hospital


ADJUNCT FACULTY

• David Kadmon, M.D., Clinical Assistant Professor ofMedicine, Roger Williams Medical Center

• Edward V. Lally, M.D., Associate Professor ofMedicine, Boston University, Roger Williams MedicalCenter

• Bernard Zimmermann, M.D., Adjunct AssociateProfessor, Roger Williams Medical Center

FACULTY TRANSITIONS

NEW FACULTY

Wendy Silversmith, M.D.• Rheumatology Fellowship, Roger Williams Medical

Center/Rhode Island Hospital

Research and OtherScholarly ActivitiesRADIUS clinical trial, a prospective observational

outcomes trial of patients with rheumatoid arthritis.

RHEUMATOLOGY FELLOWSHIP PROGRAMDeparting Fellows

Name Medical School Residency Post Graduate PlansVictoria Michaels, M.D. SUNY Syracuse Brown Internal Medicine Rheumatology practice, Albany, NY

Medical School Residency, Rhode Island Hospital

Lisa Harrington, M.D. Boston University Northwestern University Rheumatology Practice, Warwick, RIMedical School Residency in Internal Medicine

Wendy Silversmith, M.D. SUNY Stony Brook Brown Internal Medicine University Medicine FoundationMedical School Residency, Rhode Island Hospital Academic Practice, Division of

Rheumatology, Rhode Island Hospital

Current Fellows

Name Medical School ResidencyHarald Alexander Hall MD The Chicago Medical School Boston University Medicine Residency

Roger Williams Medical Center

Brenda Burke, DO University of New England College of Boston University Medicine ResidencyOsteopathic Medicine Roger Williams Medical Center

Julia Circiumaru, M.D. Carol Davila University of Medicine Danbury Hospital Residency in Internal MedicineBucharest, Romania

TEACHING ACTIVITIES

The Division of Rheumatology is actively involved in

the fellowship program, which is coordinated with the

Roger Williams Medical Center. Fellows rotate

between Rhode Island Hospital, Roger Williams

Medical Center and the Veterans Administration

Medical Center to learn the scientific basis of the

pathophysiology and treatment of rheumatic diseases.

Fellows also participate in clinical research.

The Division also teaches the Pathophysiology Course

on Rheumatology to second year Brown Medical

School students.

CLINICAL RESEARCH

Stuart Schwartz, M.D.

• Rheumatoid Arthritis DMARD Intervention andUtilization Study, Immunex Corporation

MEDICAL GRAND ROUNDS(below) Daniel M. Goodenberger, MD, Chief, Division of Medical Education, John Milliken Department of

Medicine, Medical Director, Hereditary Hemorrhagic Telangiectasia Center, Professor of Medicine, of

Medicine, St. Louis, Missouri . (bottom) Dr. Goodenberger presents “Current Understanding of Hereditary

Hemorrhagic Telangiectasia” at Rhode Island Hospital Grand Rounds.

GRAND ROUNDS

MEDICAL GRAND ROUNDSJuly 2001 – June 2003July 10, 2001 “Geriatrics Update”, Robert S. Crausman, M.D., Assistant Professor of Medicine, Brown

Medical School

July 17, 2001 “CT and Chest X-Ray Screening for Lung Cancer: Survival, Mortality, and Policy”, Gary M.

Strauss, M.D., MPH, Assistant Professor of Medicine, Harvard Medical School

July 24, 2001 Morbidity & Mortality Conference – “A 21-Year-Old Man from Guatemala with Fever, Ear

Pain, and Headaches”, Presenter: Jeanne Oliva, M.D., Clinical Instructor of Medicine,

Brown Medical School. Panelists: John Lonks, M.D., Assistant Professor of Medicine,

Brown Medical School; Marjorie Murphy, M.D., Clinical Assistant Professor of Surgery,

Brown Medical School; John Duncan, III, M.D., Ph.D., Assistant Professor of Clinical

Neurosciences, Brown Medical School

July 31, 2001 “Tactics and Strategies in the Management of Rheumatoid Arthritis”, Daniel A. Albert, M.D.,

Associate Professor of Medicine, University of Pennsylvania

September 11, 2001 Neurology Update – “Management of Asymptomatic Carotid Stenosis”, J. Donald Easton,

M.D., Professor and Chairman, Department of Clinical Neurosciences, Brown Medical

School

“Update in Epilepsy Therapeutics”, Andrew S. Blum, M.D., Ph.D., Assistant Professor of

Clinical Neurosciences, Brown Medical School

September 25, 2001 “Is Weight Loss Beneficial for Preventing Diabetes and its Macrovascular Complications?”,

Rena R. Wing, Ph.D., Professor of Psychiatry and Human Behavior, Brown Medical School

October 2, 2001 “Pulmonary Complications of HIV Infection in the Era of Highly Active Antiretroviral

Therapy (HAART)”, Mark J. Rosen, M.D., Professor of Medicine, Albert Einstein College

of Medicine

October 9, 2001 “Brown-Kenya Medical Exchange Program: Lessons For and From Both Worlds”, E. Jane

Carter, M.D., Clinical Assistant Professor of Medicine, Brown Medical School

October 16, 2001 “The Relationship Between the Pharmaceutical Industry and Physicians: Ethical Problems”,

Richard L. Allman, M.D., Associate Professor of Medicine, Temple University School of

Medicine; Herbert Rakatansky, M.D., Clinical Professor of Medicine, Brown Medical

School;

Fred J. Schiffman, M.D., Professor of Medicine, Vice Chairman of Medicine, Brown

Medical School

October 23, 2001 Nutrition Update – “Nutritional Support”, Jorge E. Albina, M.D., Professor of Surgery,


October 30, 2001 “Biological Warfare, Bioterrorism and Defense”, Andrew W. Artenstein, M.D., FACP, Clinical

Assistant Professor of Medicine, Brown Medical School

November 6, 2001 “What the Internist Needs to Know about Colorectal Cancer”, Robert J. Mayer, M.D.,

Professor of Medicine, Harvard Medical School

GRAND ROUNDS

November 13, 2001 Obstetric Medicine Update – “Thrombotic Disease in Pregnancy”, Karen Rosene Montella,

M.D., Associate Professor of Medicine and Obstetrics and Gynecology, Brown Medical School

“Cholestasis of Pregnancy”, Catherine Nelson-Piercy, M.D., Consultant Obstetric Physician,

Whipps Cross Hospital, Guy’s & St. Thomas’ Hospitals, London, England. (Dr. Nelson-

Piercy’s visit is paid for by a Brown University lectureship committee project entitled

“Visiting Professor in Obstetric Medicine” with funds from the “C.V. Starr Foundation

Lectureship Fund”)

“Update on Hypertensive Disorders of Pregnancy”, Raymond O. Powrie, M.D., Associate

Professor of Medicine and Obstetrics and Gynecology, Brown Medical School

November 27, 2001 Morbidity & Mortality Conference – Case 1: “A 72-Year-Old Man with Alcohol Use, Leg

Pain and Falling”. Case 2: “A 63-Year-Old Man with GI Bleeding and a Lung Mass on Chest

X-Ray”. Panelists: William Corrao, M.D., Clinical Professor of Medicine, Brown Medical

School; Brian Murphy, M.D., Assistant Professor of Diagnostic Imaging (Clinical), Brown

Medical School ; Edward Marcaccio, Jr., M.D., Assistant Professor of Surgery, Brown

Medical School; Michael Stein, M.D., Associate Professor of Medicine, Brown Medical

School

December 4, 2001 2nd Annual Pearl Kameny Lectureship in Geriatric Medicine – “Biomedical Research in the

Nursing Home: Lessons Learned & Future Opportunities to Improve Life for Vulnerable

Elders”, Lewis A. Lipsitz, M.D., Professor of Medicine, Harvard Medical School. (This

lectureship is funded through a generous gift from Dr. Melvyn and Mrs. Joan Gelch in

honor of her mother. Acknowledgment also given to Steere House Nursing and

Rehabilitation Center and CareLink for their support of this program.)

December 11, 2001 Urology Update – “Current Perspectives in Urology: BPH”, Terence N. Chapman, M.D.,

Assistant Professor of Surgery, Brown Medical School

“Brief Overview of the Treatment of Female Urinary Incontinence”, Young H. Kim, M.D.,

Assistant Professor of Surgery, Brown Medical School

“Advances in Prostate Cancer”, August Zabbo, M.D., MBA, Associate Professor of Surgery,


December 18, 2001 “Socialized Medicine: The Good and The Bad – A Report from the United Kingdom”, H.

Denman Scott, M.D., MPH, FACP, Professor of Medicine and Community Health, Brown

Medical School

January 8, 2002 Plastic Surgery Update – “Cosmetic Surgery and the Aging Population”, Lee E. Edstrom,

M.D., Professor or Surgery (Plastic), Brown Medical School

“Management of the Chronic Lower Extremity Wound”, Jeffrey Weinzweig, M.D., Assistant

Professor of Surgery, Brown Medical School

January 15, 2002 “Thalassemia Syndromes – Lessons from Molecular Medicine’s Index Case”, Edward J. Benz,

Jr., M.D., Richard and Susan Smith Professor of Medicine, Professor of Pediatrics,

Professor of Pathology, Harvard Medical School

January 22, 2002 “Kuru and Mad Cow Disease”, G. Richard Olds, M.D., The Linda and John Mellowes

Professor and Chair, Department of Medicine, Medical College of Wisconsin, Adjunct

Professor, Department of Medicine, Case Western Reserve University

January 29, 2002 The Herbert C. Lichtman, M.D. Oration on Medical Ethics – “The Angel of Bethesda: The

Role of Smallpox in American History”, Stanley M. Aronson, M.D., MPH, Dean of Medicine

Emeritus, University Professor of Medical Science, Brown Medical School

GRAND ROUNDS

February 5, 2002 Morbidity & Mortality Conference – “End of Life and Pain Management”, Presenter:

Muhammed Akhtar, M.D., Panelists: Joan Teno, M.D., Associate Professor of Community

Health and Medicine, Brown Medical School; Thomas Bledsoe, M.D., Clinical Assistant

Professor of Medicine, Brown Medical School; Fred Vohr, M.D., Clinical Assistant

Professor of Medicine, Brown Medical School

February 12, 2002 “Helicobacter pylori: Ecology of a Gastric Organism”, Martin J. Blaser, M.D., The Frederick

H. King Professor and Chairman, Department of Medicine, Professor of Microbiology,

New York University School of Medicine

February 19, 2002 “Immunomodulation: An Approach to Inflammatory Diseases of the Peritoneum”, Dennis L.

Kasper, M.D., Executive Dean for Academic Programs, Professor of Microbiology and

Molecular Genetics, Harvard Medical School

February 26, 2002 Allergy Update – “Management of Anaphylaxis”, Russell A. Settipane, M.D., Clinical


“Penicillin Allergy Update”, Joel K. Weltman, M.D., Ph.D., Clinical Professor of Medicine,


March 5, 2002 “Update on Management of Hypertension in Diabetes”, Sharon Anderson, M.D., Professor

of Medicine, Oregon Health Sciences University

March 12, 2002 Infectious Diseases Update – “Resistant Pneumococcus: Watch Out!”, John R. Lonks, M.D.,


“What’s New for HIV Treatment?”, Timothy P. Flanigan, M.D., Associate Professor of

Medicine, Brown Medical School

March 19, 2002 Case Management Conference – Case 1: “A 44-Year-Old Woman with Right Sided Mid-

Lower Abdominal Pain of 4 Days Duration”, Douglas Shemin, M.D., Clinical Associate

Professor of Medicine, Brown Medical School; Timothy Murphy, M.D., Associate

Professor of Diagnostic Imaging, Brown Medical School

Case 2: “A 31-Year-Old Male with 5 Weeks of Proximal Muscle Weakness and 5 Days of

Worsening Dyspnea”, Yousaf Ali, M.D., Clinical Instructor of Medicine, Brown Medical

School; Selina Cortez, M.D., Assistant Professor of Pathology & Laboratory Medicine,


March 26, 2002 “Treating Hyperlipidemia: What to do if the Statins Fail”, Paul D. Thompson, M.D.,

FACSM, Professor of Medicine, University of Connecticut School of Medicine

April 2, 2002 “Transfusion & Thrombophilia: 2002”, Joseph D. Sweeney, M.D., Associate Professor of

Medicine, Pathology and Laboratory Medicine, Brown Medical School

April 9, 2002 “New Treatment Strategies in the Treatment of Septic Shock”, Steven M. Opal, M.D.,


April 16, 2002 “Controversies in the Management of Nosocomial Pneumonia”, Michael S. Niederman,

M.D., FACP, FCCP, FCCM, Professor of Medicine, Health Science Center, State University

of New York at Stony Brook

April 23, 2002 Combined Update in Cardiology & Endocrine – “Diabetes and The Heart”, Marc

Laufgraben, M.D., Assistant Professor of Medicine, Brown Medical School; David

Williams, M.D., Professor of Medicine, Brown Medical School; Athena Poppas, M.D.,


GRAND ROUNDS

April 30, 2002 Gastroenterology Update – “Management of H. Pylori Infection – Who, How and Why”,

Steven F. Moss, M.D., Associate Professor of Medicine, Brown Medical School

“NERD: Is your patient overly sensitive?”, Harlan G. Rich, M.D., Associate Professor of


“Nonalcoholic Steatohepatitis and Insulin Resistance”, György Baffy, M.D., Ph.D., Assistant


May 7, 2002 “The New Stem Cell Biology”, Peter J. Quesenberry, M.D., Professor of Medicine, Boston

University School of Medicine

May 14, 2002 Hematology/Oncology Update – “Pancreatic Cancer Update”, Howard Safran, M.D.,

Associate Professor of Medicine, Brown Medical School

“Chronic Myelogenous Leukemia: A Model Disease for Targeted Therapy”, Alan Rosmarin,

M.D., Associate Professor of Medicine, Brown Medical School

May 21, 2002 2nd Annual Grace McLeod Rego Memorial Lecture – “The Academy at Harvard Medical

School”, George E. Thibault, M.D., Professor of Medicine, Harvard Medical School

June 4, 2002 Genetics Update – “Overview of Clinical Genetics”, and “Hereditary Cancers: Breast/Ovarian

Cancer Syndrome and Hereditary Nonpolyposis Colorectal Cancer”, Dianne N. Abuelo, M.D.,

Associate Professor of Pediatrics, Brown Medical School

June 11, 2002 “Legionnaires’ Disease: New Insights and Controversies”, Victor L. Yu, M.D., Professor of

Medicine (with tenure), University of Pittsburgh School of Medicine

June 18, 2002 “Current Concepts in Primary Prevention of Sudden Cardiac Death”, Alfred E. Buxton, M.D.,


June 25, 2002 Case Management Conference – “A 19-year-old male with flu-like gastrointestinal illness,

weakness, and lightheadedness”, James V. Hennessey, M.D., Associate Professor of Medicine,


“A 31-year-old male construction worker with fever of two weeks duration along with a

productive cough and headaches”, Staci A. Fischer, M.D., Assistant Professor of Medicine,


July 9, 2002 Psychiatry Update – “Update on Treatment of Cognitive Deficits of Alzheimer’s Disease”,

Richard J. Goldberg, M.D., Professor, Department of Psychiatry and Human Behavior,


“Combining Pharmacology and Psychotherapy in the Treatment of Depression. When to do what?”

Gabor I. Keitner, M.D., Professor, Department of Psychiatry and Human Behavior, Brown

Medical School

July 16, 2002 “Atrial Fibrillation and Flutter: Current Understanding of Mechanisms and Contemporary

Management”, Gregory Michaud, M.D., Assistant Professor of Medicine, Brown Medical

School, Malcolm M. Kirk, M.D., Assistant Professor of Medicine, Brown Medical School

July 23, 2002 “Contemporary Management of Acute Coronary Syndromes”, George McKendall, M.D.,


July 30, 2002 “Cryptogenic Stroke and PFO Closure”, Thomas M. Drew, M.D., Clinical Associate Professor

of Medicine, Brown Medical School

September 10, 2002 “New Developments in Infectious Diseases”, Robert C. Moellering, Jr., M.D., Herrman L.

Blumgart Professor of Medicine, Harvard Medical School

GRAND ROUNDS

September 17, 2002 Nephrology Update – “Recent Developments in Renal Replacement Therapy (RRT) of Acute

Renal Failure”, Douglas Shemin, M.D., Clinical Associate Professor of Medicine, Brown

Medical School, “Hyperhomocysteinemia in Chronic Renal Disease: The Chronic Renal

Transplantation ‘Model’ ”, Andrew G. Bostom, M.D., Associate Professor of Medicine,


September 24, 2002 “Methods of Science and Science of Medicine”, Ralph I. Horwitz, M.D., Harold H. Hines, Jr.

Professor of Medicine and Epidemiology, Yale University School of Medicine

October 1, 2002 “The Reach of Vaccines”, Adel A. F. Mahmoud, M.D., Ph.D., Adjunct Professor of Medicine,

Case Western Reserve University

October 8, 2002 Psycho-Social Update – “Update on Domestic Violence for Practitioners”, Susan J. Duffy,

M.D., MPH, Assistant Professor of Pediatrics, Brown Medical School

“Are You Competent to Assess Competency?”, Tomas A. Bledsoe, M.D., FACP, Clinical


October 22, 2002 Morbidity & Mortality Conference – Case 1: “A 22-year-old male with a history of renal

insufficiency presenting with seizure activity”, Presenter: Dominic Tammaro, M.D.,

Panelists: James Gilchist, M.D., Lance Dworkin, M.D., Howard Safran, M.D., Staci Fischer,

M.D., Leslie Robinson-Bostom, M.D., Douglas Shemin, M.D.

Case 2: “A 21-year-old male presenting with a large cavitary lung mass”, Panelists: William

Corrao, M.D., Gerald Abbott, M.D., Staci Fischer, M.D.

October 29, 2002 “The Asthma Epidemic: Is it Genes, the Environment, or Both?”, Scott T. Weiss, M.D., MS,

Professor of Medicine, Harvard Medical School, Professor of Environmental Health

(Epidemiology), Harvard School of Public Health

November 5, 2002 Morbidity & Mortality Conference – Case 1: “A 77-year-old man with new onset ascites”,

Presenter: Kelly McGarry, M.D., Panelists: Nicholas Ward, M.D., Louis McCombs, M.D.,

Harlan Rich, M.D.

Case 2: “An 80-year-old white female with mental status changes and back pain”, Presenter:

Michael Maher, M.D., Panelists: Staci Fischer, M.D., Jeff Rogg, M.D.

November 12, 2002 Pulmonary Update – “Pulmonary Hypertension Update”, James R. Klinger, M.D., Associate


“Lung Cancer Update”, Muhanned A. Abu-Hijleh, M.D., Teaching Fellow, Pulmonary and

Critical Care Medicine, Brown Medical School

November 19, 2002 The Galkin Lecture – “Case Studies in HIV”, Merle A. Sande, M.D., Professor of Medicine,

and the Clarence M. and Ruth N. Birrer Presidential Endowed Chair in Internal Medicine,

University of Utah School of Medicine

November 26, 2002 “Patient Safety: How Do We Recognize & Reduce Our Mistakes?”, Alan S. Kliger, M.D.,

Clinical Professor of Medicine, Yale University School of Medicine

December 3, 2002 Surgery Update – “Update on Carotid Surgery”, Jeffrey M. Slaiby, M.D., Assistant Professor

of Surgery, Brown Medical School

“Update in Bariatric Surgery”, G. Dean Roye, M.D., Assistant Professor of Surgery, Brown

Medical School

“Update on Hemorrhoidal Surgery”, Fabio M. Potenti, M.D., Assistant Professor of Surgery,


GRAND ROUNDS

December 10, 2002 The 3rd Annual Pearl Kameny Lectureship in Geriatric Medicine – “Improving Long-term

Care in the U.S.”, Joseph G. Ouslander, M.D., Professor of Medicine, Emory University

School of Medicine, Professor, Adult and Elder Health, Nell Hodgson Woodruff School of

Nursing

December 17, 2002 Morbidity & Mortality Conference – Case 1: “A 54-year-old man with acute onset flank

pain”, Presenter: Sooyun Chun, M.D., Panelists: Anita Kestin, M.D., Lance Dworkin, M.D.,

Leonard Mermel, D.O.

Case 2: “A 36-year-old white male with weight loss, fevers and flash pulmonary edema”,

Presenter: Brian Kimble, M.D., Panelists: Athena Poppas, M.D., Wendy Clough, M.D.

January 7, 2003 Neurology Update – “Blood Pressure, Stroke and PROGRESS”, J. Donald Easton, M.D.,

Professor and Chairman, Department of Clinical Neuroscience, Brown Medical School

“Epilepsy Update: The Refractory Patient”, Andrew S. Blum, M.D., Ph.D., Assistant

Professor of Clinical Neuroscience, Brown Medical School

“Migraine”, Syed A. Rizvi, M.D.

January 14, 2003 “Physical Diagnosis: Still a Tool for Our Times?”, Jack Ende, M.D., Professor of Medicine,

University of Pennsylvania School of Medicine

January 21, 2003 “Coronary Intervention: 2003”, David O. Williams, M.D., Professor Medicine, Division of

Biological and Medical Sciences, Brown Medical School

January 28, 2003 Morbidity & Mortality Conference – Case 1: “A 36-year-old woman admitted with aseptic

meningitis, discharged to home, returned and admitted to medical intensive care unit”,

Presenter: Michael Stein, M.D., Panelists: Staci Fischer, M.D., Gary Johnson, M.D.

Case 2: “A 63-year-old male presents after a fall and was found to be tachypneic”, Presenter:

Michael Maher, M.D., Panelists: J. Gary Abuelo, M.D., James Klinger, M.D.

February 4, 2003 “The Healthier Berkshires: Progress Toward a Healthier Community”, A. Gray Ellrodt, M.D.,

Professor of Medicine, UMASS Medical School

February 11, 2003 Endocrine Update – “Update on Postmenopausal Osteoporosis”, Geetha Gopalakrishnan,

M.D., Assistant Professor of Medicine, Brown Medical School

“Combination Therapy for Type 2 Diabetes”, Marc J. Laufgraben, M.D., Clinical Assistant


February 25, 2003 “Current Management of Atrial Fibrillation and Flutter – Impact of Recent Clinical Trials”,

Alfred E. Buxton, M.D., Professor of Medicine, Brown Medical School

March 4, 2003 “Pre-Operative Therapy for Stage I/II Breast Cancer: An Opportunity for Clinical Research”,

Eric P. Winer, M.D., Associate Professor of Medicine, Harvard Medical School

March 11, 2003 ENT Update – “Funtional Endoscopic Sinus Surgery”, Robert G. McRae, M.D., Clinical

Assistant Professor, Department of Surgery, Division of Otolaryngology, Brown Medical

School, Adjunct Assistant Clinical Professor, Department of Otolaryngology, Tufts

University School of Medicine

“Cochlear Implantation in Rhode Island”, Brian E. Duff, M.D., Assistant Clinical Professor

of Otolaryngology – Head and Neck Surgery, Brown Medical School, Assistant Professor

of Otolaryngology – Head and Neck Surgery, Tufts University School of Medicine

“Hoarseness”, Charles M. Ruhl, M.D., Associate Clinical Professor, Department of

Otolaryngology – Head and Neck Surgery, Tufts University School of Medicine

GRAND ROUNDS

March 18, 2003 “Targeted Therapy in Leukemia”, Richard M. Stone, M.D., Associate Professor of Medicine,

Harvard Medical School

March 25, 2003 Morbidity & Mortality Conference – Case 1: “A 70-year-old male presents with SOB and

acute renal failure”, Presenter: Frank Capizzo, M.D., Panelists: James Klinger, M.D.,

Reginald Gohh, M.D.

Case 2: “An 82-year-old female presents with ST elevation MI treated with TNK”, Presenter:

Keith Landesman, M.D., Panelists: Janet Wilterdink, M.D.,George McKendall, M.D.

April 1, 2003 “What You Should Know About Smallpox Vaccination”, Leonard A. Mermel, D.O., Associate

Professor of Medicine, Brown Medical School, John P. Fulton, Ph.D., Clinical Associate

Professor of Community Health, Brown Medical School

April 8, 2003 “Molecular Genetics of Hypertension”, Friedrich C. Luft, M.D., Professor of Medicine,

Humboldt University of Berlin, Germany

April 15, 2003 “Sleep: Too Much – Too Little”, Richard P. Millman, M.D., Professor of Medicine, Brown

Medical School, Michael L. Stanchina, M.D., Assistant Professor of Medicine, Brown

Medical School

April 22, 2003 Morbidity & Mortality Conference – Case 1: “A 44-year-old female with chronic alcoholism

presents with progressive worsening mentation”, Presenter: Anne Moulton, M.D., Panelists:

Andrew Blum, M.D., Josiah Rich, M.D., Suzanne Delamonte, M.D.

Case 2: “A 65-year-old woman with nausea, fever and failure to thrive”, Presenter: Sadie

Peters, M.D., Panelists: Paul Akerman, M.D., Michael Stanchina, M.D., Philip Stockwell,

M.D.

April 29, 2003 Rheumatology Update – “Sjögren’s Syndrome”, Stuart T. Schwartz, M.D., Clinical Assistant


“Behçet’s Syndrome: A Review”, Wendy R. Silversmith, M.D., Clinical Instructor of


May 6, 2003 “Contemporary Management of Heart Failure: Medical Therapy and Mechanical

Interventions for Advanced Disease”, Philip H. Stockwell, M.D., Clinical Assistant Professor

of Medicine, Brown Medical School, David DeNofrio, M.D., Associate Professor of

Medicine, Tufts University School of Medicine, Adjunct Associate Professor of Medicine,


May 13, 2003 The Grace McLeod Rego Memorial Lecture – “Revolutionizing the Doctor’s Black Bag: The

Time is Now”, David B. Hellmann, M.D., Mary Betty Stevens Professor of Medicine, Johns

Hopkins University School of Medicine

May 20, 2003 Update on Women’s Health – “Primary Prevention of Coronary Artery Disease in Women”,

Anne W. Moulton, M.D., Associate Professor of Medicine, Brown Medical School

“Menopause Treatments in the Wake of WHI (Women’s Health Initiative)”, Michele G. Cyr,

M.D., Associate Professor of Medicine, Associate Dean for Graduate Medical Education,


“Hearts + Hormones – Discussion of the Estrogen Plus Progestin Findings of the Women’s

Health Initiative”, Charles B. Eaton, M.D., Professor of Family Medicine, Brown Medical

School

GRAND ROUNDS

June 3, 2003 Morbidity & Mortality Conference – Case 1: “A 78-year-old female with fatigue and

persistent fever”, Presenter: Francis Basile, Jr., M.D., Panelists: E. Jane Carter, M.D.,

Timothy Flanigan, M.D., Wendy Silversmith, M.D.

Case 2: “A 21-year-old African American male presenting with chest pain, night sweats,

weight loss, nonproductive cough”, Presenter: Charles Tate, M.D., Panelists: E. Jane Carter,

M.D., Leonard Mermel, D.O., Marilyn Weigner, M.D.

June 10, 2003 “SARS – The Next Great Pandemic?”, Leonard A. Mermel, D.O., Associate Professor of


June 17, 2003 “Low Back Pain”, Phillip R. Lucas, M.D., Assistant Clinical Professor of Orthopedics,

Brown Medical School, Glenn A. Tung, M.D., Associate Professor of Diagnostic Imaging,

Brown Medical School, Lewis R. Weiner, M.D., Clinical Assistant Professor of Medicine,


June 24, 2003 “Update on Irritable Bowel Syndrome: What’s New and What to Do”, Arnold Wald, M.D.,

Professor of Medicine, University of Pittsburgh School of Medicine

Dr. John Snyder, Chief Medical Resident,

presents at the Resident’s Morning

Report, Rhode Island Hospital.

CLINICAL / RESEARCH ACTIVITY

CLINICAL ACTIVITYThe clinical volume for the Department of Medicine has risen steadily over the last four years. This has been true

on an inpatient and outpatient basis for most of the four hospitals that we serve. Clinical volume includes 31,146

patients seen as inpatients and 348,446 outpatients. This patient volume represents an extremely strong platform

on which to build our academic programs. It is also gratifying to be able to take care of that many patients in the

State of Rhode Island and provide the very best care.

FOUR YEAR PERIOD INCLUDING FY1998-1999, FY1999-2000, FY2000-2001 AND FY2001-2002

Rhode Island HospitalFY 98/99 FY 99/00 FY 00/01 FY 01/02

Inpatient Admissions 12700 11647 11909 13477

Outpatient Volume 122296 126846 142861 132793

Memorial Hospital of Rhode IslandFY 98/99 FY 99/00 FY 00/01 FY 01/02

Inpatient Admissions 7617 7896 7560 7698

Ambulatory Visits 22125 26277 26740 41197

The Miriam HospitalFY 98/99 FY 99/00 FY 00/01 FY 01/02

Inpatient Admissions/Cases 7604 7532 8219 8273

Outpatient Volume 42124 37009 43504 81775

Providence Veterans Administration Medical CenterFY 1999 FY 2000 FY 2001 FY2002

Admissions 1836 1809 1642 1779

Discharges 1750 1718 1558 1698

Outpatient Visits 77800 81532 85292 92681

The Providence VA operates a Teledermatology Program to evaluate and treat patients from the Togus VA Medical

Center. This medical center is the only hospital in the Brown Consortium which offers this service. The

Teledermatology Program offers a unique training opportunity for dermatology residents in the Brown Medical

School Program.

revised: 8/04/03

Significant Events

The Department of Medicine developed a new integrated Family Medicine/Internal Medicine Division of

Geriatrics at Memorial Hospital of Rhode Island. The new division has ongoing primary care, consultative,

nursing home, and homebound clinical programs. In addition, the division is serving as a major training site for

the new Brown Geriatrics Fellowship.


RESEARCH ACTIVITY

Brown University has long been regarded as a

leader in all aspects of health care and teaching, includ-

ing research. In 1998, the recruitment of Dr. Edward

Wing as the Chief of Medicine signaled an acceleration

of an already growing and expansive commitment to

basic and clinical research within the Brown University

Academic Medical Center Department of Medicine.

Research funding within the Department of Medicine

at Rhode Island Hospital, Memorial Hospital of Rhode

Island, Veterans Administration-Providence and The

Miriam Hospital grew from $9.9 million in 1997 to

over $25.7 million in 2002 - an increase of over 150%.

Over 75% of current funding comes from federal

programs such as NIH, HRSA, CDC, and HHS. We

expect that total research funding will be $28 million by

the end of 2003.

The major research laboratories, animal facilities and

centers at Brown are located among all the affiliates

with Rhode Island Hospital accounting for the majority

(57% of overall Department of Medicine funding).

These laboratories are highlighted by the Galletti Re-

search Building, a 60,000+ square foot research facility,

which houses the Liver Research Center, Diabetes

Research Center, and Infectious Disease laboratories.

Both basic and clinical research are well represented in

the Department. For basic research, major strengths

include the Liver Research Center (directed by Dr.

Jack Wands, who was recently awarded a Merit Review

award and a training grant in Gastroenterology from

the National Institutes of Health), Diabetes Research

Center (directed by Dr. Robert Smith), and Medical

Oncology, which recently received a multi-million

dollar COBRE grant from the National Institutes of

Health for establishing a Proteomics Core laboratory

and a Center for Cancer Research Development.

Clinical Research strengths include the Infectious

Disease program under Dr. Timothy Flanigan, which

has a major program in both domestic and

international HIV/AIDS (including an NIH funded

Center for AIDS Research program and T-32 Training

grant from NIH), General Internal Medicine

Substance Abuse Research Unit, under Dr. Michael

Stein, and the Cardiology research groups under Dr.

David Williams (Interventional Cardiology) and Dr.

Alfred Buxton (Electrophysiology).

With ongoing recruitments for both senior and junior

faculty, increasing successes of our existing faculty,

and several renovation and expansion projects in the

planning stages at each affiliated institution, research

for the Department of Medicine should continue to

grow and become even stronger in the future.


$35,000,000

$30,000,000

$25,000,000

$20,000,000

$15,000,000

$10,000,000

$5,000,000

$0

RESEARCH GROWTH FY96 - FY03

FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03

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RIH

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TMH

RHODE ISLAND HOSPITAL – HASBRO CHILDREN’S HOSPITAL

Rhode Island Hospital (RIH), is a private, 719-bed, not-for-profit, acute

care hospital and a major teaching hospital for Brown Medical School.

Founded in 1863, RIH is the largest of the state’s general acute care

hospitals, providing comprehensive health services.

The hospital provides comprehensive diagnostic and therapeutic services

to inpatients and outpatients, with particular expertise in cardiology,

oncology, neurosciences and orthopedics, as well as pediatrics at its

Hasbro Children’s Hospital. RIH is also designated as the Level I Trauma

Center for southeastern New England, providing expert staff and

equipment in emergency situations 24 hours a day.

The state’s premier pediatric facility, Hasbro Children’s Hospital (HCH)

is the pediatric division of Rhode Island Hospital. Built in 1994, the

seven-story building was designed in collaboration with doctors, nurses

and other health care professionals, as well as parents and children. It has

earned worldwide recognition for its family-centered environment and

expert staff. It has won numerous architectural and health care related

awards.

HCH has the area’s only pediatric intensive care unit and pediatric

oncology and cardiac programs, has separate emergency and surgical

units designated for pediatric patients, and operates specialty clinics

treating children ranging in age from newborn to 18 years.

Annually, the hospital cares for some 6,000 inpatients and 30,000

outpatients. The lower level of HCH provides ambulatory services in a

child-friendly atmosphere including a life-sized playhouse. The pediatric

emergency Department serves the needs of young trauma patients as well

as children needing less acute care. The emergency Department is staffed

24 hours a day, seven days a week by specialists trained in pediatric

emergency medicine and other pediatric subspecialties.

Rhode Island Hospital

Hasbro Children’s Hospital

Brown Medical School was established in 1975 and was quickly

established as one of the premiere medical schools in the U.S.

Brown has a unique Program in Liberal Medical Education

(PLME) that identifies potential physicians in high school and adopts

them into an 8-year program that blends traditional medical training

with liberal arts. Brown Medical School students receive education

from researchers who are at the top of their field, and physicians from

any of eleven affiliated hospitals.

A unique and robust alliance exists between Brown University and the

Medical School through the core biomedical sciences. The multiple

disciplines are governed by a single Dean and administration

providing a direct relationship between patient care and cutting-edge

scientific research. This interdisciplinary approach is organized as the

Division of Biology and Medicine (Biomed).

B R O W N M E D I C A L S C H O O L A F F I L I A T E D H O S P I T A L S


The Memorial Hospital of Rhode Island is a 294-bed hospital

community hospital serving the Blackstone Valley and southeastern

Massachusetts. Memorial Hospital is also a Brown Medical School

teaching and research facility. In addition to the main campus in

Pawtucket, Memorial Hospital of Rhode Island and its affiliates

provide primary and ambulatory care services at sites on Quality Hill,

and in Plainville, Barrington, and Central Falls. The only Rhode Island

affiliate of Dana-Farber / Partners CancerCare, Memorial is home to a

new state of the art cancer treatment facility.

THE MIRIAM HOSPITAL

The Miriam Hospital (TMH) is a private 247-bed, not-for-profit,

acute care general hospital founded by Rhode Island’s Jewish

community in 1926. The Miriam provides a broad range of primary,

secondary and tertiary medical and surgical services to adolescents and

adults in 31 medical and surgical specialties and sub-specialties. In

addition, TMH provides a full range of cardiac, pathological and

radiology services as well as psychiatric consultation/liaison services.

TMH is affiliated with and serves as a major teaching affiliate of Brown

Medical School.

WOMEN & INFANTS HOSPITAL OF RHODE ISLAND

Women & Infants Hospital of Rhode Island, which houses 137 single

patient rooms and 120 infant bassinets, performs 70% of all obstetrical

deliveries in Rhode Island, making it the state’s largest obstetrical

service and the second largest service of its kind in New England.

There is a large companion gynecologic service, which provides the

community with a comprehensive range of medical services for

women. The hospital is the southeastern New England regional center

for the care of women and infants, serving a population of 1.5 million

people.

PROVIDENCE VA MEDICAL CENTER

The VA Medical Center is a 230-bed facility providing acute inpatient

and ambulatory care in medicine, surgery, psychiatry and neurology.

The hospital admits approximately 5,000 veterans annually and

provides over 150,000 outpatient visits in 41 clinics. It is a regional

center for treatment of Post-Traumatic Stress Disorder. The hospital

also provides special medical services in the areas of dialysis, substance

abuse treatment, rehabilitative medicine, and prosthetics.

The Miriam Hospital

Women & Infants Hospital of Rhode Island

Providence VA Medical Center

The Memorial Hospital of Rhode Island

academic - Department of Medicine at Alpert Medical School

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