A/Adelie_Penguin/Antarctica/178/2013(H11N2) A/sharp-tailed_sandpiper/Australia/10/2004(H11N9) A/duck/Vietnam/G30/2008(H11N9) A/shorebird/Delaware_Bay/747/1988(H11N9) A/Gull/Maryland/704/1977(H13N6) A/black-headed_gull/Sweden/2/99(H16N3) A/Viet_Nam/1203/2004(H5N1) A/California/07/2009(H1N1) A/USSR/90/1977(H1N1) A/Brisbane/59/2007(H1N1) A/Singapore/1/1957(H2N2) A/Hong_Kong/JY2/1968(H3N2) A/Brisbane/10/2007(H3N2) Conservation A/Adelie_Penguin/Antarctica/178/2013(H11N2) A/sharp-tailed_sandpiper/Australia/10/2004(H11N9) A/duck/Vietnam/G30/2008(H11N9) A/shorebird/Delaware_Bay/747/1988(H11N9) A/Gull/Maryland/704/1977(H13N6) A/black-headed_gull/Sweden/2/99(H16N3) A/Viet_Nam/1203/2004(H5N1) A/California/07/2009(H1N1) A/USSR/90/1977(H1N1) A/Brisbane/59/2007(H1N1) A/Singapore/1/1957(H2N2) A/Hong_Kong/JY2/1968(H3N2) A/Brisbane/10/2007(H3N2) Conservation A/Adelie_Penguin/Antarctica/178/2013(H11N2) A/sharp-tailed_sandpiper/Australia/10/2004(H11N9) A/duck/Vietnam/G30/2008(H11N9) A/shorebird/Delaware_Bay/747/1988(H11N9) A/Gull/Maryland/704/1977(H13N6) A/black-headed_gull/Sweden/2/99(H16N3) A/Viet_Nam/1203/2004(H5N1) A/California/07/2009(H1N1) A/USSR/90/1977(H1N1) A/Brisbane/59/2007(H1N1) A/Singapore/1/1957(H2N2) A/Hong_Kong/JY2/1968(H3N2) A/Brisbane/10/2007(H3N2) Conservation A/Adelie_Penguin/Antarctica/178/2013(H11N2) A/sharp-tailed_sandpiper/Australia/10/2004(H11N9) A/duck/Vietnam/G30/2008(H11N9) A/shorebird/Delaware_Bay/747/1988(H11N9) A/Gull/Maryland/704/1977(H13N6) A/black-headed_gull/Sweden/2/99(H16N3) A/Viet_Nam/1203/2004(H5N1) A/California/07/2009(H1N1) A/USSR/90/1977(H1N1) A/Brisbane/59/2007(H1N1) A/Singapore/1/1957(H2N2) A/Hong_Kong/JY2/1968(H3N2) A/Brisbane/10/2007(H3N2) Conservation A/Adelie_Penguin/Antarctica/178/2013(H11N2) A/sharp-tailed_sandpiper/Australia/10/2004(H11N9) A/duck/Vietnam/G30/2008(H11N9) A/shorebird/Delaware_Bay/747/1988(H11N9) A/Gull/Maryland/704/1977(H13N6) A/black-headed_gull/Sweden/2/99(H16N3) A/Viet_Nam/1203/2004(H5N1) A/California/07/2009(H1N1) A/USSR/90/1977(H1N1) A/Brisbane/59/2007(H1N1) A/Singapore/1/1957(H2N2) A/Hong_Kong/JY2/1968(H3N2) A/Brisbane/10/2007(H3N2) Conservation 1 1 1 1 1 1 1 1 1 1 1 1 1 101 101 101 101 103 103 101 102 102 102 100 109 109 M-E-KTLLFAAI IFYV----------KADEICIGYLSNNSTDKVDTI IENNVTVTSSVELVETEHTGSFCS-----IDGRQPISLGDCSFAGWILGNPMCDDLIGKETWSYIVEKPNP M-K-KTLLFAAIFLYV----------KADEICIGYLSNNSTDKVDTI IENNVTVTSSVELVETEHTGSFCS-----INGKQPISLGDCSFAGWILGNPMCDDLIGKTSWSYIVEKPNP M-K-KTLLFAAIFLYV----------KADEICIGYLSNNSTDKVDTI IENNVTVTSSVELVETEHTGSFCS-----INGKQPISLGDCSFAGWILGNPMCDDLIGKTSWSYIVEKPNP M-K-KTLLLATVILCV----------GADEICIGYLSNNSTDKVDTI IENNVTVTSAVELVETEHTGSFCS-----INGKQPISLGDCSFAGWILGNPMCDDLIGKNSWSYIVEKPNP MALNVIATLTLISVCV----------HADRICVGYLSTNSSERVDTLLENGVPVTSSIDLIETNHTGTYCS-----LNGVSPVHLGDCSFEGWIVGNPACTSNFGIREWSYLIEDPAA MAKTLYLLVLIFVKYS----------RADKICIGYLSNNSTDTVDTLTENGVPVTSSIDLVETNHTGTYCS-----LNGVSPIHLGDCSFEGWIVGNPSCASNINIREWSYLIEDPNA M-E-KIVLLFAIVSLV----------KSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCD-----LDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANP M-KAILVVLLYTFATA----------NADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCK-----LRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSS M-KAKLLVLLCALSAT----------DADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCR-----LKGIAPLQLGKCNIAGWILGNPECESLFSKKSWSYIAETPNS M-KVKLLVLLCTFTAT----------YADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLENSHNGKLCL-----LKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVEKPNP M---AI IYLILLFTAV----------RGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCK-----LNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENP M-K-TI IALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGI ------DCTLIDALLGDPHCDVFQN-ETWDLFVERSKA M-K-TI IALSYILCLVFTQKLPGNDNSTATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQSSSTGEICDSPHQILDGE------NCTLIDALLGDPQCDGFQN-KKWDLFVERSKA * -0- 3 5 7 4 7 4444 2 4 6 ---------- 2 7 55 + * 9 * 8 5 8 7 8 9 77 4 * 6 * 9 6 7 5 6 9 5 ** 4 8 4 7 + 9 8 444 + * 4 7 * 2 ----- + 5 * 3 0 22 0 2 0 5 * 9 7 3 5 6 + 9 * 8 * 2 * 4 2 5 4 7 1 2 4 * 77 8 7 * 5 3 4 6 102 102 102 102 104 104 102 103 103 103 101 110 110 216 217 217 217 218 217 217 219 219 218 215 221 221 T N G I C Y P G T L E N E E E L R L K F S G V L E V S K F E A F T P - N G WG N V N S G - G V T A A C K - Y G S S S S F F R Y M T W L T H K S G T Y P V I K R T F N N T K G R D V L I V WG I H H P S S L Q E H R D L Y K K D I S Y V A V G A N G I C Y P G T L E N E E E L R L K F S G V L E F S K F E A F T S - N G WG A V N S G A G V T A A C K - F G S S N S F F R H M V W L I H Q S G T Y P V I K R T F N N T K G R D V L V V WG I H H P A T L K E H Q D L Y K K D S S Y V A V G A N G I C Y P G T L E N E E E L R L K F S G V L E F S K F E A F T S - N G WG A V N S G A G V T A A C K - F G S S N S F F R N M V W L I H Q S G T Y P I I K R T F N N T K G R D V L I V WG I H H P A T L K E H Q D L Y K K D S S Y V A V G T N G I C Y P G T L E N E E E L R L K F S G V L E F S K F E V F T A - G G WG N V D S G K G V T A A C K - Y G S S N S F F R H M T W L I H K S G T Y P V I K R T F N N T R G M D V L I V WG I H H P S S L K E Q Q D L Y K K D S S Y V A V G P H G L C Y P G E L N N N G E L R H L F S G I R S F S R T E L I P P - T S WG E V L D - - G T T S A C R D N T G T N S F Y R N L V W F I K K N N R Y P V I S K T Y N N T T G R D V L V L WG I H H P V S V D E T K T L Y V N S D P Y T L V S P H K L C F P G E V D N N G E L R H L F S G V N S F S R T E L I P P - S K WG D I L E - - G T T A S C Q - N R G A N S F Y R N L I W L V N K L N K Y P V V K G E Y N N T T G R D V L V L WG I H H P D T E A T A N K L Y V N K N P Y T L V S VNDLCYPGDFNDYEELKHLLSRINHFEKIQI I P K - S S W S S H E A S L G V S S A C P - Y Q G K S S F F R N V V W L I K K N S T Y P T I K R S Y N N T N Q E D L L V L WG I H H P N D A A E Q T K L Y Q N P T T Y I S V G D N G T C Y P G D F I D Y E E L R E Q L S S V S S F E R F E I F P K T S S W P N H D S N K G V T A A C P - H A G A K S F Y K N L I W L V K K G N S Y P K L S K S Y I N D K G K E V L V L WG I H H P S T S A D Q Q S L Y Q N A D A Y V F V G E N G T C Y P G Y F A D Y E E L R E Q L S S V S S F E R F E I F P K E R S W P K H N V T R G V T A S C S - H K G K S S F Y R N L L W L T E K N G S Y P N L S K S Y V N N K E K E V L V L WG V H H P S N I E D Q K T I Y R K E N A Y V S V V E N G T C Y P G H F A D Y E E L R E Q L S S V S S F E R F E I F P K E S S W P N H T V T - G V S A S C S - H N G E S S F Y R N L L W L T G K N G L Y P N L S K S Y A N N K E K E V L V L WG V H H P P N I G N Q K A L Y H T E N A Y V S V V RDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPK-DRWTQHTTT-GGSRACA-VSGNPSFFRNMVWLTEKGSNYPVAKGSYNNTSGEQMLI I WG V H H P N D E K E Q R T L Y Q N V G T Y V S V G F S N - C Y P Y D V P D Y A S L R S L V A S S G T L - - - E F I T E G F T W T G V T Q N - G G S N A C K - R G P G S G F F S R L N W L T K S G S T Y P V L N V T M P N N D N F D K L Y I WG I H H P S T N Q E Q T S L Y V Q A S G R V T V S YSN-CYPYDVPDYASLRSLVASSGTL---EFNNESFNWTGVTQN-GTSSACI - R R S N N S F F S R L N W L T H L K F K Y P A L N V T M P N N E K F D K L Y I WG V H H P G T D N D Q I F L Y A Q A S G R I T V S 1 11 1 5 88 9 5 67 0 0 33 0 * 9 * 6 3 7 2 8 5 4 6 * 9 1 5 7 8 4 5 33 7 1 3 0 66 5 8 2 - 2 4 * 6 3 44 3 1 - * 6 9 4 8 * 2 - 3 4 6 33 8 * 9 55 8 6 * 8 6 2 33 5 3 ** 3 7 5 3 6 8 4 * 8 4 3 4 7 5 * 6 9 ** 9 *** 3 7 33 7 3 4 2 + * 2 6 1 3 666 4 * 6 217 218 218 218 219 218 218 220 220 219 216 222 222 334 335 335 335 336 334 335 337 337 336 333 338 338 SETYNRRFTPEISTRPRVNGQAGRMTFYWTI IKPGESITFESNGAFIAPRHAFDIVSVGNGKLFRSELSIGSCSTKCQTEIGGINTNKSFQSVHRNTIGDCPKYVNVKSLKLATGLRN SETYNRRFIPEISTRPKVNGQAGRMTFYWTIVKPGESITFESNGAFLAPRYAFEIVSVGNGKLFRSELNVESCSTKCQTEIGGINTNKSFHSVHRNTIGDCPKYVNVKSLKLATGLRN SETYNRRFIPEISTRPKVNGQAGRMTFYWTI IKPGESITFESNGAFLAPRYAFEIVSIGNGKLFRSELNIGSCSTKCQTEIGGINTNKSFHSVHRNTIGDCPKYVNVKSLKLATGLRN SETYNRRFTPEISTRPPVNGQAGRMTFYWTIVKPGESITFESNGAFLAPRYAFEIVSVGNGKLFRSELNIESCSTKCQTEIGGLNTSKSFHNVHKNTIGDCPKYVNVKSLKLATGLRN T K S W S E K Y K L E T G V R P G Y N G Q R S WM K I Y W S L I H P G E M I T F E S N G G F L A P R Y G Y I IEEYGKGRIFQSRIRMSRCNTKCQTSVGGINTNRTFQNIDKNALGDCPKYIKSGQLKLATGLRN T K E W S R R Y E L E I G T R I G - D G Q R S WM K I Y W H L M H P G E R I T F E S S G G L L A P R Y G Y I IEKYGTGRIFQSGVRLAKCNTKCQTSMGGINTNKTFQNIERNALGDCPKYIKSGQLKLATGLRN TSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRN SSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGI I ISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRN SSNYNRRFTPEIAERPKVRGQAGRINYYWTLLEPGDTI IFEANGNLIAPWHAFALNRGFGSGI ITSNASMDECDTKCQTPQGAINSSLPFQNIHPVTIGECPKYVRSTKLRMVTGLRN SSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTI IFEANGNLIAPRYAFALSRGFGSGI INSNAPMDKCDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRN TSTLNKRSTPDIATRPKVNGLGSRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRN TRRSQQTI IPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKM-RTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRN TKRSQQTVIPNIGSRPRVRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKI -RSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRN 22 2 22 2 56 8 9 4 3 4 8 66 4 3 666 8 2 * 4 2 1 6 5 7 2 8 6 9 4 7 5 * 4 + 8 5 7 5 9 3 + 6 8 7 8 9 * 7 8 9 8 * 5 4 6 9 2 9 0 4 2 7 3 8 4 + 8 4 9 3 5 3 6 2 4 * 3 7 5 * 7 * 44 * 8 + 8 9 7 5 7 * 6 99 44 6 77 * 3 ** 9 * 9 6 5 3 5 * 4 9 8 ** 9 ** 335 336 336 336 337 335 336 338 338 337 334 339 339 448 449 449 449 450 448 453 451 451 450 447 452 452 VPAIV----SRGLFGAIAGFIEGGWPGLINGWYGFQHRNEEGTGVAADKESTQKAIDQITSKVNNIVDRMNTNFESVHHEFSEIEERINQLSSHVDDSVIDIWSYNAQLLVLLENEKT VPAIA----SRGLFGAIAGFIEGGWPGLINGWYGFQHRNEEGTGIAADKESTQKAIDQITSKVNNIVDRMNTNSESVQHEFSEIEERINQLSKHVDDSVVDIWSYNAQLLVLLENEKT VPAIA----SRGLFGAIAGFIEGGWPGLINGWYGFQHRNEEGTGIAADKESTQKAIDQITSKVNNIVDRMNTNFESVQHEFSEIEERINQLSKHVDDSVVDIWSYNAQLLVLLENEKT VPAIA----SRGLFGAIAGFIEGGWPGLINGWYGFQHRNEEGTGIAADKESTQKAIDQITSKVNNIVDRMNTNFESVQHEFSEIEERINQLSKHVDDSVIDIWSYNAQLLVLLENEKT VPAIS----NRGLFGAIAGFIEGGWPGLINGWYGFQHQNEQGTGIAADKESTQKAIDQITTKINNI IDKMNGNYDSIRGEFNQVEKRINMLADRIDDAVTDIWSYNAKLLVLLENDKT VPSIV----ERGLFGAIAGFIEGGWPGLINGWYGFQHQNEQGTGIAADKTSTQKAINEITTKINNI IEKMNGNYDSIRGEFNQVEKRINMIADRVDDAVTDIWSYNAKLLVLIENDRT S P Q R E R R R K K R G L F G A I A G F I E G G WQ G M V D G W Y G Y H H S N E Q G S G Y A A D K E S T Q K A I D G V T N K V N S I IDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERT IPSIQ----SRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERT IPSIQ----SRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLEKRMENLNKKVDDGFLDIWTYNAELLVLLENERT IPSIQ----SRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFIDIWTYNAELLVLLENERT V P Q I E - - - - S R G L F G A I A G F I E G G WQ G M I D G W Y G Y H H S N D Q G S G Y A A D K E S T Q K A F D G I T N K V N S V I E K M N T Q F E A V G K E F S N L E R R L E N L N K K M E D G F L D V W T Y N A E L L V L M E N E R T VPEKQ----TRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHT VPEKQ----TRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGIGQAADLKSTQAAIDQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHT 5 * 4 5 3 ---- 4 ** + ********* 7 ** 5 * 99 8 **** 9 6 * 6 * 6 8 * 5 * 5 *** 55 *** 4 * 88 4 9 + 7 * 9 * 6 99 4 9 7 * 4 6 5 4 6 9 2 3 ** 9 4 9 * 3 * 9 7 5 + 44 6 8 9 * 7 4 6 * 9 * 9 *** 6 *** 7 9 ** 7 8 * 449 450 450 450 451 449 454 452 452 451 448 453 453 564 565 565 565 566 564 568 566 566 565 562 566 566 LDLHDSNVRNLHERVRRILKDNAKDEGNGCFTFYHKCNNECIERVRNGTYDHKEFEEESKINRQEIVGVKLDSNGNVYKILSIYSCIASSLVLAALVGVFILWACSNGSCRCNICI LDLHDSNVRNLHEKVRRMLKDNAKDEGNGCFTFYHKCDNECIERVRNGTYDHKEFEEESKINRQEIEGVKLDSSGNVYKILSIYSCIASSLVLAALIMGFILWACSNGSCRCTICI LDLHDSNVRNLHEKVRRMLKDNAKDEGNGCFTFYHKCDNECIERVRNGTYDHKEFKEESKINRQEIEGVKLDSSGNVYKILSIYSCIASSLVLAALIMGFILWACSNGSCRCTICI LDLHDSNVRNLHEKVRRMLKDNAKDEGNGCFTFYHKCDNECIERVRNGTYDHKEFEEESKINRQEIAGVKLDSNGNVYKILSIYSCIASSLVLAALIMGFILWACSNGSCRCNICI LDMHDANVKNLHEQVRRELKDNAIDEGNGCFELLHKCNDSCMETIRNGTYDHTEYAEESKLKRQEIDGIKLKSEDNVYKALSIYSCIASSVVLVGLILSFIMWACSSGNCRFNVCI LDLHDANVRNLHEQIKRALKDNAIDEGDGCFSILHKCNDSCMETIRNGTYNHEDYKEESQLKRQEIEGIKLKTEDNVYKILSIYSCIASSVVLVGLILAFILWACSSGNCRFNVCI LDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLKREEISGVKLESI - G I Y Q I L S I Y S T V A S S L A L A I M V A G L S L WM C S N G S L Q C R I C I L D Y H D S N V K N L Y E K V R S Q L K N N A K E I G N G C F E F Y H K C D N T C M E S V K N G T Y D Y P K Y S E E A K L N R E E I D G V K L E S T - R I Y Q I L A I Y S T V A S S L V L V V S L G A I S F WM C S N G S L Q C R I C I L D F H D S N V K N L Y E K V K S Q L K N N A K E I G N G C F E F Y H K C N N E C M E S V K N G T Y D Y P K Y S E E S K L N R E K I D G V K L E S M - G V Y Q I L A I Y S T V A S S L V L L V S L G A I S F WM C S N G S L Q C R I C I L D F H D S N V K N L Y E K V K S Q L K N N A K E I G N G C F E F Y H K C N D E C M E S V K N G T Y D Y P K Y S E E S K L N R E K I D G V K L E S M - G V Y Q I L A I Y S T V A S S L V L L V S L G A I S F WM C S N G S L Q C R I C I L D F H D S N V K N L Y D K V R M Q L R D N V K E L G N G C F E F Y H K C D D E C M N S V K N G T Y D Y P K Y E E E S K L N R N E I K G V K L S S M - G V Y Q I L A I Y A T V A G S L S L A I M M A G I S F WM C S N G S L Q C R I C I IDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSG-YKDWILWISFAI -SCFLLCVVLLGFIMWACQRGNIRCNICI IDLTDSEMNKLFEKTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGVELKSG-YKDWILWISFAI -SCFLLCVALLGFIMWACQKGNIRCNICI + * 7 5 * 8 7 8 66 * 7 9 7 6 9 33 * 9 7 * 8 4 9 5 * 8 *** 4 8 7 *** 88 4 * 9 4 6 99 **** 88 33 9 3 9 * 8 5 66 * 4 6 * 2 * 9 7 * 4 9 3 - 3 55 6 7 * 5 * 6 5 7 9 3 8 77 5 * 77 5 8 7 6 8 5 8 * 8 * 8 5 * 9 888 7 9 **