1 www.Digital-World-Biology.com Bioinformatics for Biologists Sandra Porter Digital World Biology [email protected] Bio-Link www.bio-link.org
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1www.Digital-World-Biology.com
Bioinformatics for Biologists
Sandra PorterDigital World [email protected]
Bio-Linkwww.bio-link.org
www.Digital-World-Biology.com
Bioinformatics = databases & software Bioinformatics = databases & software for working with biological informationfor working with biological information
Acquire Analyze VisualizeStore
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Who are most programs designed to serve?
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Who uses bioinformatics?
Biology is an information-rich science
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Bioinformatics in industry
Did you hear about that paper?
Instrument Run
Search PubMeddownload paper
Go to GenBankdownload sequences
Align sequences with company data
Try to clone gene
Design PCR primers
Sequence cloned gene
Make constructs for expression, sequence constructs
Use microarrays / transcriptome sequencingto look at effects of construct & ligand
look at structures, ligand binding
General
• Find information - in databases (>1300)• Analyze data• Prepare and interpret graphs• Use multiple kinds of software• Work with databases • Need practical skills for working with
computers and the internet
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Begin with molecular structures
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Investigating Influenza: How might antigenic drift affect immunity?
Ab
Hemagglutinin
Which residues contact the Ab?
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Genetic variation & pharmacogenomics
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Our course at ACC
Structures
Sequences
Variation
Gene expression
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