Mark Christopherson Vice President Product Development, Inspire Medical Systems, Inc. NANS, December 6, 2012 “A Solution for Obstructive Sleep Apnea: Closed Loop Neuromodulation: ” • The Inspire Therapy is Investigational Use Only in the Unit • Mark Christopherson is an employee of Inspire Medical Syste
“A Solution for Obstructive Sleep Apnea: Closed Loop Neuromodulation : ”. Mark Christopherson Vice President Product Development, Inspire Medical Systems, Inc. NANS, December 6, 2012. The Inspire Therapy is Investigational Use Only in the United States - PowerPoint PPT Presentation
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Mark Christopherson Vice President Product Development, Inspire Medical Systems, Inc.
NANS, December 6, 2012
“A Solution for Obstructive Sleep Apnea: Closed Loop Neuromodulation: ”
• The Inspire Therapy is Investigational Use Only in the United States• Mark Christopherson is an employee of Inspire Medical Systems
• A loss of muscle tone during sleep allowing the upper airway to narrow or close… a physiologic issue
Definition of Obstructive Sleep Apnea
AHI = Apnea/Hypopnea Index is number of events per hour
Sufferers stop breathing for periods of up to 20-30 seconds as many as 40-50 times per hour
Breathing cessations eventually cause the brain to send what is essentially a wake-up call to the body
Many co-morbidities have been directly linked with Obstructive Sleep Apnea…
Early Mortality
High Blood Pressure
Congestive Heart Failure
Stroke
Neuro-cognitive Problems
Daytime Sleepiness
Job Impairment
Fatigue-related accidents
Health Consequences of OSA
Prevalence of OSA and Clinical Treatment Guidelines – United States
Surgical Intervention
Oral Appliance
CPAP
Remain Untreated
Fail CPAP30%-60%
Moderate to Severe OSA in
>30 yrs old:
Diagnosed20%
Many patients remain untreated or undertreated
+13 million patients
Moderate to Severe OSA Treatments
Invasiveness Low High
Intr
usiv
enes
s Lo
wH
igh (CPAP) • Gold standard
• ~1 mil units per year• Low compliance 50%
Maxillofacial advancement
• Facial reconstruction
• Good clinical results• <2k procedures / yr
Upper Airway Stimulation addresses and unmet need: Less invasive, durable results, high patient compliance